Genomes and Genes
Summary: Cells on the luminal surface of the SYNOVIAL MEMBRANE. Type A synoviocytes are MACROPHAGES responsible for waste removal from the joint cavity. Fibroblast-like type B synoviocytes are involved in production of joint matrix constituents (e.g., HYALURONAN; COLLAGEN; and FIBRONECTIN).
- Chang W, Jan Wu Y, Chung W, Lee Y, Chin S, Chen T, et al. Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis. Rheumatology (Oxford). 2017;56:457-466 pubmed publisher..These data suggest that variants of PPARGC1B , a regulator of metabolism and inflammation, contribute to the pathogenesis of gouty arthritis. ..
- Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, et al. Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2017;19:76 pubmed publisher..Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients exhibit several tumor cell-like characteristics; however, the ..
- Wehmeyer C, Pap T, Buckley C, Naylor A. The role of stromal cells in inflammatory bone loss. Clin Exp Immunol. 2017;189:1-11 pubmed publisher..Fibroblast-like synoviocytes (FLS) are the most abundant cells of the stroma and a key population in autoimmune diseases such as RA...
- Wang W, Liu J, Yang B, Ma Z, Liu G, Shen W, et al. Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes. PLoS ONE. 2017;12:e0181003 pubmed publisher..Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction...
- Loupasakis K, Kuo D, Sokhi U, Sohn C, Syracuse B, Giannopoulou E, et al. Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes. PLoS ONE. 2017;12:e0179762 pubmed publisherDuring rheumatoid arthritis (RA), Tumor Necrosis Factor (TNF) activates fibroblast-like synoviocytes (FLS) inducing in a temporal order a constellation of genes, which perpetuate synovial inflammation...
- Crowley T, O Neil J, Adams H, Thomas A, Filer A, Buckley C, et al. Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts. Arthritis Res Ther. 2017;19:35 pubmed publisher..This study sought to examine negative feedback mechanisms in fibroblast-like synoviocytes (FLS), one of the most abundant cell types in the joint...