synoviocytes

Summary

Summary: Cells on the luminal surface of the SYNOVIAL MEMBRANE. Type A synoviocytes are MACROPHAGES responsible for waste removal from the joint cavity. Fibroblast-like type B synoviocytes are involved in production of joint matrix constituents (e.g., HYALURONAN; COLLAGEN; and FIBRONECTIN).

Top Publications

  1. Zhu S, Huang J, Peng W, Wu D, Luo M, Li Q, et al. Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis. Cell Mol Immunol. 2017;14:214-222 pubmed publisher
    Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Smoothened (Smo) is a key component of sonic hedgehog (Shh) signaling and contributes to tumor cell proliferation...
  2. Farinon M, Clarimundo V, Pedrazza G, Gulko P, Zuanazzi J, Xavier R, et al. Disease modifying anti-rheumatic activity of the alkaloid montanine on experimental arthritis and fibroblast-like synoviocytes. Eur J Pharmacol. 2017;799:180-187 pubmed publisher
    ..two arthritis models and its effect in vitro on lymphocyte proliferation and on invasiveness of fibroblast-like synoviocytes (FLS)...
  3. Thomsen L, Thomsen P, Downing A, Talbot R, Berg L. FOXO1, PXK, PYCARD and SAMD9L are differentially expressed by fibroblast-like cells in equine synovial membrane compared to joint capsule. BMC Vet Res. 2017;13:106 pubmed publisher
    ..Equine synovial membrane research is hampered by a lack of markers of fibroblast-like synoviocytes (FLS) to distinguish FLS from other fibroblast-like cells in musculoskeletal connective tissues...
  4. Tanner M, Pennington M, Laragione T, Gulko P, Beeton C. KCa1.1 channels regulate ?1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes. FASEB J. 2017;31:3309-3320 pubmed publisher
    ..is the predominant potassium channel expressed at the plasma membrane of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) isolated from the synovium of patients with RA...
  5. Li N, Xu Q, Liu Q, Pan D, Jiang Y, Liu M, et al. Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis. Rheumatology (Oxford). 2017;56:1417-1427 pubmed publisher
    ..Fibroblast-like synoviocytes were isolated from synovial tissue from RA patients...
  6. Wang Y, Zhou C, Gao H, Li C, Li D, Liu P, et al. Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation. Biochem Pharmacol. 2017;138:119-129 pubmed publisher
    ..Our study suggested that the anti-arthritis effects of CTS were attained through suppression of p300-mediated STAT3 acetylation. Our data suggest that CTS might be a potential immune modulator for RA treatment. ..
  7. Fan P, He L, Hu N, Luo J, Zhang J, Mo L, et al. Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis. Cell Physiol Biochem. 2017;42:145-155 pubmed publisher
    This study aims to investigate the regulatory mechanism of 1,25-(OH)2D3 on the proliferation of fibroblast-like synoviocytes (FLS) and expressions of pro-inflammatory cytokines in rheumatoid arthritis (RA) rats via microRNA-22 (miR-22)...
  8. Matsuda S, Hammaker D, Topolewski K, Briegel K, Boyle D, DOWDY S, et al. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017;199:2316-2322 pubmed publisher
    Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) display unique aggressive behavior, invading the articular cartilage and promoting inflammation...
  9. Totzke J, Gurbani D, Raphemot R, Hughes P, Bodoor K, Carlson D, et al. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-? Inhibition for Cancer and Autoimmune Disease. Cell Chem Biol. 2017;24:1029-1039.e7 pubmed publisher
    ..Overall, Takinib is an attractive starting point for the development of inhibitors that sensitize cells to TNF-?-induced cell death, with general implications for cancer and autoimmune disease treatment. ..

More Information

Publications15

  1. Chang W, Jan Wu Y, Chung W, Lee Y, Chin S, Chen T, et al. Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis. Rheumatology (Oxford). 2017;56:457-466 pubmed publisher
    ..These data suggest that variants of PPARGC1B , a regulator of metabolism and inflammation, contribute to the pathogenesis of gouty arthritis. ..
  2. Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, et al. Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2017;19:76 pubmed publisher
    ..Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients exhibit several tumor cell-like characteristics; however, the ..
  3. Wehmeyer C, Pap T, Buckley C, Naylor A. The role of stromal cells in inflammatory bone loss. Clin Exp Immunol. 2017;189:1-11 pubmed publisher
    ..Fibroblast-like synoviocytes (FLS) are the most abundant cells of the stroma and a key population in autoimmune diseases such as RA...
  4. Wang W, Liu J, Yang B, Ma Z, Liu G, Shen W, et al. Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes. PLoS ONE. 2017;12:e0181003 pubmed publisher
    ..Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction...
  5. Loupasakis K, Kuo D, Sokhi U, Sohn C, Syracuse B, Giannopoulou E, et al. Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes. PLoS ONE. 2017;12:e0179762 pubmed publisher
    During rheumatoid arthritis (RA), Tumor Necrosis Factor (TNF) activates fibroblast-like synoviocytes (FLS) inducing in a temporal order a constellation of genes, which perpetuate synovial inflammation...
  6. Crowley T, O Neil J, Adams H, Thomas A, Filer A, Buckley C, et al. Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts. Arthritis Res Ther. 2017;19:35 pubmed publisher
    ..This study sought to examine negative feedback mechanisms in fibroblast-like synoviocytes (FLS), one of the most abundant cell types in the joint...