odontoblasts

Summary

Summary: The mesenchymal cells which line the DENTAL PULP CAVITY and produce DENTIN. They have a columnar morphology in the coronal pulp but are cuboidal in the root pulp, or when adjacent to tertiary dentin.

Top Publications

  1. Keller J, Carrouel F, Colomb E, Durand S, Baudouin C, Msika P, et al. Toll-like receptor 2 activation by lipoteichoic acid induces differential production of pro-inflammatory cytokines in human odontoblasts, dental pulp fibroblasts and immature dendritic cells. Immunobiology. 2010;215:53-9 pubmed publisher
    b>Odontoblasts, dental pulp fibroblasts and immature dendritic cells (DCs) have been involved in the human dental pulp immune response to oral pathogens that invade dentine during the caries process...
  2. Sakai V, Zhang Z, Dong Z, Neiva K, Machado M, Shi S, et al. SHED differentiate into functional odontoblasts and endothelium. J Dent Res. 2010;89:791-6 pubmed publisher
    ..we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional odontoblasts and endothelial cells...
  3. Lee J, Lee D, Choung H, Shon W, Seo B, Lee E, et al. Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors. Biomaterials. 2011;32:9696-706 pubmed publisher
    The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation...
  4. Sakai V, Cordeiro M, Dong Z, Zhang Z, Zeitlin B, Nor J. Tooth slice/scaffold model of dental pulp tissue engineering. Adv Dent Res. 2011;23:325-32 pubmed publisher
    ..subpopulation of stem cells that exhibit multipotency, as demonstrated by their ability to differentiate into odontoblasts, neural cells, and vascular endothelial cells...
  5. Choi B, Yun S, Jeong S, Wang G, Kim H, Lim D, et al. Expression of thymosin ?4 in odontoblasts during mouse tooth development. Int J Mol Med. 2012;29:841-7 pubmed publisher
    ..T?4 is expressed during molar development in mice, but the expression and function of T?4 in odontoblasts during mammalian tooth development have not yet been reported...
  6. Tsumura M, Okumura R, Tatsuyama S, Ichikawa H, Muramatsu T, Matsuda T, et al. Ca2+ extrusion via Na+-Ca2+ exchangers in rat odontoblasts. J Endod. 2010;36:668-74 pubmed publisher
    ..Although expression of NCX1 isoforms has been demonstrated in odontoblasts, the detailed properties of NCX remain to be clarified...
  7. Feng J, Mantesso A, De Bari C, Nishiyama A, Sharpe P. Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A. 2011;108:6503-8 pubmed publisher
    ..lineage tracing, we show that some pericytes differentiate into specialized tooth mesenchyme-derived cells--odontoblasts--during tooth growth and in response to damage in vivo...
  8. Couve E, Osorio R, Schmachtenberg O. Mitochondrial autophagy and lipofuscin accumulation in aging odontoblasts. J Dent Res. 2012;91:696-701 pubmed publisher
    ..In human teeth, odontoblasts are post-mitotic cells responsible for sensory function and dentin preservation...
  9. Lee D, Park J, Kim H, Ko J, Son H, Gronostajski R, et al. Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development. J Biol Chem. 2009;284:17293-303 pubmed publisher
    ..have demonstrated that nuclear factor I-C (NFI-C) null mice developed short molar roots that contain aberrant odontoblasts and abnormal dentin formation...

More Information

Publications62

  1. Oh S, Hwang Y, Yang H, Kang J, Hur S, Jung N, et al. SHP is involved in BMP2-induced odontoblast differentiation. J Dent Res. 2012;91:1124-9 pubmed publisher
    ..In an immunostaining study, SHP was expressed in odontoblasts and surrounding osteoblasts...
  2. Liu H, Lin H, Zhang L, Sun Q, Yuan G, Zhang L, et al. miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop. J Biol Chem. 2013;288:9261-71 pubmed publisher
    Dentin tissue is derived from mesenchymal cells induced into the odontoblast lineage. The differentiation of odontoblasts is a complex process regulated by several transcriptional factor signaling transduction pathways...
  3. Takeda T, Tezuka Y, Horiuchi M, Hosono K, Iida K, Hatakeyama D, et al. Characterization of dental pulp stem cells of human tooth germs. J Dent Res. 2008;87:676-81 pubmed
    ..The results of a DNA array experiment showed that the expression of several genes, such as WNT16, was markedly changed with an increasing number of passages, which might have caused the loss of their characteristics as hDPSCs...
  4. Magloire H, Maurin J, Couble M, Shibukawa Y, Tsumura M, Thivichon Prince B, et al. Topical review. Dental pain and odontoblasts: facts and hypotheses. J Orofac Pain. 2010;24:335-49 pubmed
    ..the architecture of dentin could allow for the transfer of information to the underlying dental pulp via odontoblasts (dentin-forming cells), via their apical extension bathed in the dentinal fluid running in the tubules, or via ..
  5. Horst O, Horst J, Samudrala R, Dale B. Caries induced cytokine network in the odontoblast layer of human teeth. BMC Immunol. 2011;12:9 pubmed publisher
    Immunologic responses of the tooth to caries begin with odontoblasts recognizing carious bacteria. Inflammatory propagation eventually leads to tooth pulp necrosis and danger to health...
  6. Lee S, Lee S, Lee S, Park J, Jang J, Kim H, et al. Effect of calcium phosphate cements on growth and odontoblastic differentiation in human dental pulp cells. J Endod. 2010;36:1537-42 pubmed publisher
    ..The purpose of this study was to investigate the effects of CPCs on the mechanical properties, growth, and odontoblastic differentiation in HDPCs compared with Portland cement (PC) and mineral trioxide aggregate (MTA)...
  7. Cho Y, Yoon W, Woo K, Baek J, Park J, Ryoo H. The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J Biol Chem. 2010;285:36369-76 pubmed publisher
    ..BMP-2 provides a strong signal for differentiation and mineralization of odontoblasts and osteoblasts...
  8. Couve E, Schmachtenberg O. Autophagic activity and aging in human odontoblasts. J Dent Res. 2011;90:523-8 pubmed publisher
    b>Odontoblasts are long-lived post-mitotic cells in the dental pulp, whose function is to form and maintain dentin...
  9. Kim M, Reyna J, Chen L, Zeichner David M. Role of the transcription factor NFIC in odontoblast gene expression. J Calif Dent Assoc. 2009;37:875-81 pubmed
  10. Son A, Yang Y, Hong J, Lee S, Shibukawa Y, Shin D. Odontoblast TRP channels and thermo/mechanical transmission. J Dent Res. 2009;88:1014-9 pubmed publisher
    b>Odontoblasts function as mechanosensory receptors because of the expression of mechanosensitive channels in these cells. However, it is unclear if odontoblasts direct the signal transmission evoked by heat/cold or osmotic changes...
  11. San Miguel S, Fatahi M, Li H, Igwe J, Aguila H, Kalajzic I. Defining a visual marker of osteoprogenitor cells within the periodontium. J Periodontal Res. 2010;45:60-70 pubmed publisher
    ..To identify an osteoprogenitor population, this study utilized a transgenic model in which an alpha-smooth muscle actin (alphaSMA) promoter directed green fluorescent protein (GFP) expression...
  12. Paula Silva F, Ghosh A, Silva L, Kapila Y. TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res. 2009;88:339-44 pubmed publisher
    ..These findings indicate that TNF-alpha stimulates differentiation of dental pulp cells toward an odontoblastic phenotype via p38, while negatively regulating MMP-1 expression...
  13. Goldberg M, Farges J, Lacerda Pinheiro S, Six N, Jegat N, Decup F, et al. Inflammatory and immunological aspects of dental pulp repair. Pharmacol Res. 2008;58:137-47 pubmed publisher
    ..Recognition of bacteria by specific odontoblast and fibroblast membrane receptors triggers an inflammatory and immune response within the pulp tissue that would also modulate the repair process...
  14. Dommisch H, Steglich M, Eberhard J, Winter J, Jepsen S. Phosphatidylinositol-3-kinase inhibitor LY 294002 blocks Streptococcus mutans-induced interleukin (IL)-6 and IL-8 gene expression in odontoblast-like cells. Int Endod J. 2008;41:763-71 pubmed publisher
    ..To investigate the involvement of the phosphatidylinositol-3-kinase (PI3K) in interleukin-6 (IL-6) and interleukin-8 (IL-8) gene expression in odontoblast-like cells when exposed to heat-killed Streptococcus mutans...
  15. Kim S, Min K, Ryu H, Lee H, Kim E. The role of heme oxygenase-1 in the proliferation and odontoblastic differentiation of human dental pulp cells. J Endod. 2010;36:1326-31 pubmed publisher
    ..The purpose of this study was to investigate the role of HO-1 in the growth and differentiation of human dental pulp cells (HDPCs)...
  16. Arany S, Kawagoe M, Sugiyama T. Application of spontaneously immortalized odontoblast cells in tooth regeneration. Biochem Biophys Res Commun. 2009;381:84-9 pubmed publisher
    ..capable of intercellular and cell-matrix communication, thus they eventually differentiated into functional odontoblasts. In summary, we managed to utilize OLCs for dental mesenchyme substitution in tooth regeneration experiments...
  17. Li Y, Lu Y, Maciejewska I, Galler K, Cavender A, D Souza R. TWIST1 promotes the odontoblast-like differentiation of dental stem cells. Adv Dent Res. 2011;23:280-4 pubmed publisher
    ..derived from the dental pulp of extracted human third molars (DPSCs) have the potential to differentiate into odontoblasts, osteoblasts, adipocytes, and neural cells when provided with the appropriate conditions...
  18. Chen J, Lan Y, Baek J, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009;334:174-85 pubmed publisher
    ..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
  19. Lee S, Min K, Choi G, Park J, Park S, Lee S, et al. Effects of simvastain and enamel matrix derivative on Portland cement with bismuth oxide-induced growth and odontoblastic differentiation in human dental pulp cells. J Endod. 2012;38:405-10 pubmed publisher
    ..The aim of this study was to evaluate the effects of simvastatin and Emdogain on BPC compared with mineral trioxide aggregate (MTA) in human dental pulp cells (HDPCs)...
  20. Qin W, Yang F, Deng R, Li D, Song Z, Tian Y, et al. Smad 1/5 is involved in bone morphogenetic protein-2-induced odontoblastic differentiation in human dental pulp cells. J Endod. 2012;38:66-71 pubmed publisher
    ..However, the mechanism by which BMP-2 induces odontoblastic differentiation has not yet been established. In the present study, we examined the involvement of the BMP/Smad pathway in mediating odontoblastic differentiation in DPCs...
  21. Yao N, Li S, Jiang Y, Qiu S, Tan Y. Amelogenin promotes odontoblast-like MDPC-23 cell differentiation via activation of ERK1/2 and p38 MAPK. Mol Cell Biochem. 2011;355:91-7 pubmed publisher
    ..Some research indicates that AMG might induce the differentiation and maturation of odontoblasts. The aim of this study was to clarify the function of AMG during the differentiation of odontoblast-like MDPC-..
  22. Nait Lechguer A, Couble M, Labert N, Kuchler Bopp S, Keller L, Magloire H, et al. Cell differentiation and matrix organization in engineered teeth. J Dent Res. 2011;90:583-9 pubmed publisher
    ..After two weeks of implantation, the re-associations showed gradients of differentiating odontoblasts. There were ciliated, polarized, and extended cell processes in predentin/dentin. Ameloblasts became functional...
  23. Zhang R, Yang G, Wu X, Xie J, Yang X, Li T. Disruption of Wnt/?-catenin signaling in odontoblasts and cementoblasts arrests tooth root development in postnatal mouse teeth. Int J Biol Sci. 2013;9:228-36 pubmed publisher
    ..In the present study, we conditionally knock out ?-catenin gene (Ctnnb1) within developing odontoblasts and cementoblasts during the development of tooth roots, and observed rootless molars as well as incomplete ..
  24. Alsanea R, Ravindran S, Fayad M, Johnson B, Wenckus C, Hao J, et al. Biomimetic approach to perforation repair using dental pulp stem cells and dentin matrix protein 1. J Endod. 2011;37:1092-7 pubmed publisher
    ..This study was conducted to evaluate the ability of dental pulp stem cells (DPSCs) and dentin matrix protein 1 (DMP1) impregnated within a collagen scaffold to regenerate dentin...
  25. Sato M, Sobhan U, Tsumura M, Kuroda H, Soya M, Masamura A, et al. Hypotonic-induced stretching of plasma membrane activates transient receptor potential vanilloid channels and sodium-calcium exchangers in mouse odontoblasts. J Endod. 2013;39:779-87 pubmed publisher
    ..of transient receptor potential (TRP) channels have been identified as membrane-bound sensory proteins in odontoblasts. However, the activation properties of these channels remain to be clarified...
  26. Ma D, Zhang R, Sun Y, Rios H, Haruyama N, Han X, et al. A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem. 2011;286:4302-9 pubmed publisher
    ..Our key findings are 1) periostin is expressed in preodontoblasts, and odontoblasts; and the periostin-null incisor displayed a massive increase in dentin formation after mastication; 2) ..
  27. Wen J, Tao R, Ni L, Duan Q, Lu Q. Immunolocalization and expression of Runx2 in tertiary dentinogenesis. Hybridoma (Larchmt). 2010;29:195-9 pubmed publisher
    ..Taken together, the expression of Runx2 has temporal and spatial specificity during different phases in rat tertiary dentinogenesis...
  28. Lee T, Lee D, Kim H, Ko J, Gronostajski R, Cho M, et al. Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation. J Histochem Cytochem. 2009;57:469-76 pubmed publisher
    ..Nfic-deficient mice exhibited aberrant odontoblasts and abnormal dentin formation in molar roots and the labial crown analog of incisors...
  29. Sun Y, Lu Y, Chen S, Prasad M, Wang X, Zhu Q, et al. Key proteolytic cleavage site and full-length form of DSPP. J Dent Res. 2010;89:498-503 pubmed publisher
    ..The results of this study revealed the presence of full-length DSPP and its processed fragments in extracts from the pulp/odontoblast and dentin...
  30. Duan X, Mao Y, Yang T, Wen X, Wang H, Hou J, et al. ClC-5 regulates dentin development through TGF-beta1 pathway. Arch Oral Biol. 2009;54:1118-24 pubmed publisher
    ..We suggest that the dentin changes in ClC-5 KO mice might be a result of increasing TGF-beta1, and the interplay between ClC-5 and TGF-beta1 needs further identified...
  31. Lee S, Lee C, Kook Y, Lee S, Kim E. Mechanical stress promotes odontoblastic differentiation via the heme oxygenase-1 pathway in human dental pulp cell line. Life Sci. 2010;86:107-14 pubmed publisher
    ..In this study, we examined the effects of MS on the odontoblastic differentiation of immortalized HDPCs and on the primary intracellular signaling pathways, including the HO-1 pathway, implicated in this differentiation...
  32. Kim Y, Min K, Jeong D, Jang J, Kim H, Kim E. Effects of fibroblast growth factor-2 on the expression and regulation of chemokines in human dental pulp cells. J Endod. 2010;36:1824-30 pubmed publisher
    ..This study investigated whether human dental pulp cells (HDPCs) treated with FGF-2 could express chemokines during differentiation into odontoblastic cells and sought to identify its underlying mechanism of action...
  33. Tabatabaei F, Ai J, Jafarzadeh Kashi T, Khazaei M, Kajbafzadeh A, Ghanbari Z. Effect of dentine matrix proteins on human endometrial adult stem-like cells: in vitro regeneration of odontoblasts cells. Arch Oral Biol. 2013;58:871-9 pubmed publisher
    ..Human endometrium has enormous regenerative capacity due to the presence of endometrial stem cells. The present study sought to assess the possibility of differentiation of these cells into odontoblast-like cells by in vitro induction...
  34. Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z. Establishment and characterization of a tamoxifen-mediated reversible immortalized mouse dental papilla cell line. In Vitro Cell Dev Biol Anim. 2013;49:114-21 pubmed publisher
    b>Odontoblasts are a type of non-proliferating and terminally differentiated cells that play an important role in the pulpo-dentinal complex...
  35. Horst O, Tompkins K, Coats S, Braham P, Darveau R, Dale B. TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria. J Dent Res. 2009;88:333-8 pubmed publisher
    ..b>Odontoblasts extending their cellular processes into the dentin are the first cells to recognize signals from TGF-beta1 and ..
  36. Lee S, Kim S, Park S, Kim J, Jang J, Kim E. Effects of recombinant dentin sialoprotein in dental pulp cells. J Dent Res. 2012;91:407-12 pubmed publisher
  37. Charadram N, Farahani R, Harty D, Rathsam C, Swain M, Hunter N. Regulation of reactionary dentin formation by odontoblasts in response to polymicrobial invasion of dentin matrix. Bone. 2012;50:265-75 pubmed publisher
    ..Microbial invasion of dentin in caries triggers an adaptive response by odontoblasts, culminating in formation of a structurally altered reactionary dentin, marked by biochemical and architectonic ..
  38. Bronckers A, Kalogeraki L, Jorna H, Wilke M, Bervoets T, Lyaruu D, et al. The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in maturation stage ameloblasts, odontoblasts and bone cells. Bone. 2010;46:1188-96 pubmed publisher
    ..A granular intracellular immunostaining of variable intensity was also noted in bone cells and odontoblasts. In Cftr-deficient mice the incisors were chalky white and eroded much faster than in wild type mice...
  39. Min K, Lee Y, Hong S, Kim E. Simvastatin promotes odontoblastic differentiation and expression of angiogenic factors via heme oxygenase-1 in primary cultured human dental pulp cells. J Endod. 2010;36:447-52 pubmed publisher
    ..In addition, the role of heme oxygenase-1 (HO-1) in these effects was investigated...
  40. Li Y, Lu X, Sun X, Bai S, Li S, Shi J. Odontoblast-like cell differentiation and dentin formation induced with TGF-?1. Arch Oral Biol. 2011;56:1221-9 pubmed publisher
    ..To investigate the inductive potential of scaffold material combing with transforming growth factor-?1 (TGF-?1), and to induce odontoblast differentiation and dentin formation from dental pulp cells both in vitro and in vivo...
  41. Li J, Huang X, Xu X, Mayo J, Bringas P, Jiang R, et al. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011;138:1977-89 pubmed publisher
    ..cranial neural crest (CNC) cells during tooth and jawbone formation as these cells differentiate into odontoblasts and osteoblasts, respectively...
  42. Wu L, Feng J, Wang L, Mu Y, Baker A, Donly K, et al. Immortalized mouse floxed Bmp2 dental papilla mesenchymal cell lines preserve odontoblastic phenotype and respond to BMP2. J Cell Physiol. 2010;225:132-9 pubmed publisher
    ..of cell lines that serve as good surrogate models for the study of dental mesenchymal cell differentiation into odontoblasts and mineralization...
  43. Han X, Liu M, Voisey A, Ren Y, Kurimoto P, Gao T, et al. Post-natal effect of overexpressed DKK1 on mandibular molar formation. J Dent Res. 2011;90:1312-7 pubmed publisher
    ..formation rate; (3) a small malformed second molar and an absent third molar; (4) an increase of immature odontoblasts, few mature odontoblasts, and sharply reduced dentinal tubules; and (5) a dramatic change in Osx and nestin ..
  44. Thivichon Prince B, Couble M, Giamarchi A, Delmas P, Franco B, Romio L, et al. Primary cilia of odontoblasts: possible role in molar morphogenesis. J Dent Res. 2009;88:910-5 pubmed publisher
    A primary cilium, a sensory organelle present in almost every vertebrate cell, is regularly described in odontoblasts, projecting from the surfaces of the cells...
  45. Karube H, Nishitai G, Inageda K, Kurosu H, Matsuoka M. NaF activates MAPKs and induces apoptosis in odontoblast-like cells. J Dent Res. 2009;88:461-5 pubmed publisher
    The cytotoxic effects of fluoride on odontoblasts are not clear...
  46. Casagrande L, Demarco F, Zhang Z, Araujo F, Shi S, Nor J. Dentin-derived BMP-2 and odontoblast differentiation. J Dent Res. 2010;89:603-8 pubmed publisher
    It is known that stem cells from exfoliated deciduous teeth (SHED) can be induced to differentiate into odontoblasts. However, the nature of dentin-derived morphogenic signals required for dental pulp stem cell differentiation remains ..
  47. Tsumura M, Sobhan U, Muramatsu T, Sato M, Ichikawa H, Sahara Y, et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. Cell Calcium. 2012;52:124-36 pubmed publisher
    b>Odontoblasts are involved in the transduction of stimuli applied to exposed dentin...
  48. Kim J, Kim S, Kim Y, Kim S, Park S, Kim E. The role of SIRT1 on angiogenic and odontogenic potential in human dental pulp cells. J Endod. 2012;38:899-906 pubmed publisher
    ..Additionally, we investigated the effects of SIRT1 overexpression and knockdown on the differentiation of HDPCs...
  49. Biz M, Marques M, Crema V, Moriscot A, dos Santos M. GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts. Cell Tissue Res. 2010;340:459-70 pubmed publisher
    ..The aim of this study was to verify the expression, distribution, and role of Rho GTPases in ameloblasts and odontoblasts during tooth development in correlation with actin and tubulin arrangements and amelogenin and dentin ..
  50. Kim T, Bae C, Lee J, Ko S, Yang X, Jiang R, et al. ?-catenin is required in odontoblasts for tooth root formation. J Dent Res. 2013;92:215-21 pubmed publisher
    ..Tissue-specific inactivation of ?-catenin in developing odontoblasts produced molars lacking roots and aberrantly thin incisors...
  51. Magloire H, Couble M, Thivichon Prince B, Maurin J, Bleicher F. Odontoblast: a mechano-sensory cell. J Exp Zool B Mol Dev Evol. 2009;312B:416-24 pubmed publisher
    b>Odontoblasts are organized as a single layer of specialized cells responsible for dentine formation and presumably for playing a role in tooth pain transmission...
  52. Cordeiro M, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008;34:962-9 pubmed publisher
    ..This work suggests that exfoliated deciduous teeth constitute a viable source of stem cells for dental pulp tissue engineering...
  53. Chen S, Chen L, Jahangiri A, Chen B, Wu Y, Chuang H, et al. Expression and processing of small integrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells. Arch Oral Biol. 2008;53:879-89 pubmed publisher
    ..The aim of this study was to identify expression and processing of the five proteins in two mouse odontoblastic cell lines...