mast cells

Summary

Summary: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

Top Publications

  1. Kovarova M. Isolation and characterization of mast cells in mouse models of allergic diseases. Methods Mol Biol. 2013;1032:109-19 pubmed publisher
    After their activation, mast cells release a variety of bioactive mediators that contribute to characteristic symptoms of allergic reactions...
  2. Calero Nieto F, Ng F, Wilson N, Hannah R, Moignard V, Leal Cervantes A, et al. Key regulators control distinct transcriptional programmes in blood progenitor and mast cells. EMBO J. 2014;33:1212-26 pubmed publisher
    ..Through comparative analysis of 10 key haematopoietic TFs in both mast cells and blood progenitors, we demonstrate that the largely cell type-specific binding profiles are not opportunistic,..
  3. Skaper S, Facci L, Giusti P. Mast cells, glia and neuroinflammation: partners in crime?. Immunology. 2014;141:314-27 pubmed publisher
    ..also to pro-inflammatory signals released from other non-neuronal cells, mainly those of immune origin such as mast cells. The latter are found in most tissues, are CNS resident, and traverse the blood-spinal cord and blood-brain ..
  4. Kim B, Seo H, Ku J, Kim G, Jeon C, Park J, et al. Silibinin inhibits the production of pro-inflammatory cytokines through inhibition of NF-?B signaling pathway in HMC-1 human mast cells. Inflamm Res. 2013;62:941-50 pubmed publisher
    ..It has been used for the treatment of hepatitis and inflammation-related diseases. In the present study, the effects of silibinin on allergic inflammation and its signaling were investigated in the induced human mast cells.
  5. Steinke J, Negri J, Liu L, Payne S, Borish L. Aspirin activation of eosinophils and mast cells: implications in the pathogenesis of aspirin-exacerbated respiratory disease. J Immunol. 2014;193:41-7 pubmed publisher
    ..CD34+ progenitor-derived mast cells were also used to test the influence of aspirin on human mast cells with measurements of Ca2+ flux and PGD2 ..
  6. Yu S, Zhang R, Zhu C, Cheng J, Wang H, Wu J. MicroRNA-143 downregulates interleukin-13 receptor alpha1 in human mast cells. Int J Mol Sci. 2013;14:16958-69 pubmed publisher
    ..It indicates that miR-143 directly targets IL-13R?1 and suppresses IL-13R?1 expression in HMC-1 cells. Therefore, miR-143 may be associated with allergic reaction in human mast cells.
  7. Malfettone A, Silvestris N, Saponaro C, Ranieri G, Russo A, Caruso S, et al. High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression. J Cell Mol Med. 2013;17:1025-37 pubmed publisher
    Tryptase(+) mast cells (MCs), abundant in the invasive front of tumours, contribute to tissue remodelling. Indeed, protease-activated receptor-2 (PAR-2) activation by MC-tryptase is considered an oncogenic event in colorectal cancer (CRC)...
  8. Leveson Gower D, Sega E, Kalesnikoff J, Florek M, Pan Y, Pierini A, et al. Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells. Blood. 2013;122:3659-65 pubmed publisher
    To investigate the role of mast cells in hematopoietic cell transplantation, we assessed graft-versus-host disease (GVHD) in C57BL/6-Kit(W-sh/W-sh) recipients, which virtually lack mast cells, compared with C57BL/6 WT recipients...
  9. Nakamura T, Otsuka S, Ichii O, Sakata Y, Nagasaki K, Hashimoto Y, et al. Relationship between numerous mast cells and early follicular development in neonatal MRL/MpJ mouse ovaries. PLoS ONE. 2013;8:e77246 pubmed publisher
    ..During this period, we found numerous mast cells in the ovary of MRL/MpJ mice and investigated their appearance and morphology with follicular development...

More Information

Publications62

  1. Nakamura Y, Oscherwitz J, Cease K, Chan S, Muñoz Planillo R, Hasegawa M, et al. Staphylococcus ?-toxin induces allergic skin disease by activating mast cells. Nature. 2013;503:397-401 pubmed publisher
    ..b>Mast cells contribute to immunoglobulin-E-mediated allergic disorders including atopic dermatitis...
  2. Rieger J, Twardziok S, Huenigen H, Hirschberg R, Plendl J. Porcine intestinal mast cells. Evaluation of different fixatives for histochemical staining techniques considering tissue shrinkage. Eur J Histochem. 2013;57:e21 pubmed publisher
    Staining of mast cells (MCs), including porcine ones, is critically dependent upon the fixation and staining technique. In the pig, mucosal and submucosal MCs do not stain or stain only faintly after formalin fixation...
  3. Hirai S, Ohyane C, Kim Y, Lin S, Goto T, Takahashi N, et al. Involvement of mast cells in adipose tissue fibrosis. Am J Physiol Endocrinol Metab. 2014;306:E247-55 pubmed publisher
    ..adipose tissue is characterized by chronic inflammation with massive accumulation of immune cells including mast cells. The objective of the present study was to clarify the relationship between fibrosis and mast cells in obese ..
  4. Hasan D, Chalouhi N, Jabbour P, Hashimoto T. Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results. J Neuroinflammation. 2012;9:222 pubmed publisher
    ..This study aims to investigate the role of macrophage M1/M2 imbalance and mast cells in the progression of human cerebral aneurysms to rupture.
  5. Cheng L, Hartmann K, Roers A, Krummel M, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013;38:166-75 pubmed publisher
    b>Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE)...
  6. Avila M, Martínez Juárez A, Ibarra Sanchez A, Gonzalez Espinosa C. Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells. Innate Immun. 2012;18:648-60 pubmed publisher
    b>Mast cells (MCs) control allergic reactions and contribute to protective innate immune responses through TLR4 activation...
  7. Baumann A, Gönnenwein S, Bischoff S, Sherman H, Chapnik N, Froy O, et al. The circadian clock is functional in eosinophils and mast cells. Immunology. 2013;140:465-74 pubmed publisher
    ..b>Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-..
  8. Bounab Y, Getahun A, Cambier J, Daëron M. Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol. 2013;25:313-20 pubmed publisher
    ..The resultant confusion has been further increased by discoveries of new players. Here we provide a review of recent progress in defining the roles of these enzymes in immunoreceptor-dependent mast cell, T cell and B cell activation. ..
  9. Maaninka K, Lappalainen J, Kovanen P. Human mast cells arise from a common circulating progenitor. J Allergy Clin Immunol. 2013;132:463-9.e3 pubmed publisher
    Human tissue mast cells (MCs) have the potential to express several neutral granule proteases, which are the most precise markers of the phenotypic heterogeneity of MCs...
  10. Raica M, Cimpean A, Ceausu R, Ribatti D, Gaje P. Interplay between mast cells and lymphatic vessels in different molecular types of breast cancer. Anticancer Res. 2013;33:957-63 pubmed
    ..Molecular classification of breast tumors by immunohistochemistry was followed by the detection of mast cells and lymphatic vessels on the same slide by immunohistochemical double-stain method, using the lymphatic ..
  11. Janicki J, Spinale F, Levick S. Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase. Pflugers Arch. 2013;465:687-97 pubmed publisher
    ..In view of the fact that, in male mice with PO, mast cells have been shown to play a role in the adverse remodeling suggests favorable estrogen modification of mast cell ..
  12. Jeong H, Nam S, Han N, Kim Y, Kim J, Lee S, et al. The critical role of mast cell-derived hypoxia-inducible factor-1? in human and mice melanoma growth. Int J Cancer. 2013;132:2492-501 pubmed publisher
    b>Mast cells play an important role in tumorigenesis. Histamine released from mast cells stimulates new vessel formation by acting through the histamine1 (H1) receptor...
  13. Zhang H, Yang H, Ma W, Zhang Z, He S. Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29. Cytokine. 2013;61:469-77 pubmed publisher
    ..of IL-29 on protease activated receptor (PAR) expression and potential mechanisms of cytokine production in mast cells. In the present study, we examined potential influence of IL-29 on PAR expression and cytokine production in ..
  14. Ng S, Bakowski D, Nelson C, Mehta R, Almeyda R, Bates G, et al. Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression. Nature. 2012;482:111-5 pubmed publisher
    ..Hence, rather than serving to turn off a biological response, reversible desensitization of a Ca(2+) mobilizing receptor acts as an 'on' switch, sustaining long-term signalling in the immune system...
  15. Gupta K, Subramanian H, Klos A, Ali H. Phosphorylation of C3a receptor at multiple sites mediates desensitization, ?-arrestin-2 recruitment and inhibition of NF-?B activity in mast cells. PLoS ONE. 2012;7:e46369 pubmed publisher
    ..we have recently shown that GRK2, GRK3 and ?-arrestin-2 promote C3a receptor (C3aR) desensitization in human mast cells. We also demonstrated that ?-arrestin-2 provides an inhibitory signal for NF-?B activation...
  16. Staser K, Shew M, Michels E, Mwanthi M, Yang F, Clapp D, et al. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. Exp Hematol. 2013;41:56-66.e2 pubmed publisher
    b>Mast cells coordinate allergy and allergic asthma and are crucial cellular targets in therapeutic approaches to inflammatory disease...
  17. Hsu C, Bryce P. Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway. J Immunol. 2012;189:3421-9 pubmed
    ..Although several cells display constitutive expression of IL-33, we showed previously that mast cells expressed low levels of IL-33 constitutively but that IL-33 was induced upon IgE-mediated activation...
  18. Srivastava S, Cai X, Li Z, Sun Y, Skolnik E. Phosphatidylinositol-3-kinase C2? and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells. Mol Cell Biol. 2012;32:3132-9 pubmed publisher
    Cross-linking of the IgE receptor (Fc?RI) on mast cells plays a critical role in IgE-dependent allergy, including allergic rhinitis, asthma, anaphylaxis, and immediate-type hypersensitivity reactions...
  19. Macglashan D. IgE-dependent signaling as a therapeutic target for allergies. Trends Pharmacol Sci. 2012;33:502-9 pubmed publisher
    ..b>Mast cells and basophils are central to the immediate hypersensitivity reaction that is mediated by IgE...
  20. Moreno Sanchez D, Hernandez Ruiz L, Ruiz F, Docampo R. Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J Biol Chem. 2012;287:28435-44 pubmed publisher
    ..The presence of polyP of 60 phosphate units was identified in rat basophilic leukemia (RBL-2H3) mast cells using specific enzymatic assays, urea-polyacrylamide gel electrophoresis of cell extracts, and staining of cells ..
  21. Gilfillan A, Beaven M. Regulation of mast cell responses in health and disease. Crit Rev Immunol. 2011;31:475-529 pubmed
    b>Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection...
  22. Fang Y, Larsson L, Bruhns P, Xiang Z. Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors Fc?RIIB and Fc?RIIIA. Allergy. 2012;67:1233-40 pubmed publisher
    b>Mast cells are important effector cells in allergy. They usually have a long life span and resist cell death induction...
  23. Rönnberg E, Melo F, Pejler G. Mast cell proteoglycans. J Histochem Cytochem. 2012;60:950-62 pubmed publisher
    b>Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease...
  24. Huang P, Liu D, Gan X, Zhang R, Gao W, Xia Z, et al. Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats. Injury. 2012;43:1250-6 pubmed publisher
    ..Mast cell activation plays an important role in IIR injury. It is unknown whether IIR mediates lung injury via mast cell activation...
  25. Georgin Lavialle S, Lhermitte L, Suarez F, Yang Y, Letard S, Hanssens K, et al. Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor. Eur J Haematol. 2012;89:47-52 pubmed publisher
    ..Our aim was to investigate c-Kit mutations associated with mast cell leukemia and find new treatment for this severe form of mastocytosis...
  26. Sismanopoulos N, Delivanis D, Alysandratos K, Angelidou A, Therianou A, Kalogeromitros D, et al. Mast cells in allergic and inflammatory diseases. Curr Pharm Des. 2012;18:2261-77 pubmed
    b>Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity...
  27. Pardanani A. Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management. Am J Hematol. 2012;87:401-11 pubmed publisher
    Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extra-cutaneous organs.
  28. Ji Y, Sakata Y, Yang Q, Li X, Xu M, Yoder S, et al. Activation of rat intestinal mucosal mast cells by fat absorption. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1292-300 pubmed publisher
    ..We determined whether fat absorption activates intestinal mucosal mast cells (MMC), a key component of the gut mucosal immune system. Conscious intestinal lymph fistula rats were used...
  29. Tanaka T, Ishikawa H. Mast cells and inflammation-associated colorectal carcinogenesis. Semin Immunopathol. 2013;35:245-54 pubmed publisher
    ..In an inflammatory microenvironment, infiltrating macrophages and mast cells mediate production of these inflammatory mediators to promote growth of tumors in target tissues...
  30. Huang S, Lu F, Chen Y, Huang B, Liu M. Mast cell degranulation in human periodontitis. J Periodontol. 2013;84:248-55 pubmed publisher
    b>Mast cells are tissue-resident immune cells that participate in a variety of allergic and inflammatory conditions...
  31. Xu J, Shi G. Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev. 2012;33:71-108 pubmed publisher
    b>Mast cells are essential in allergic immune responses. Recent discoveries have revealed their direct participation in cardiovascular diseases and metabolic disorders...
  32. Meng Z, Yan C, Deng Q, Dong X, Duan Z, Gao D, et al. Oxidized low-density lipoprotein induces inflammatory responses in cultured human mast cells via Toll-like receptor 4. Cell Physiol Biochem. 2013;31:842-53 pubmed publisher
    ..b>Mast cells can infiltrate into the atheromatous plaque and secrete various pro-inflammatory cytokines, which significantly ..
  33. Shaik Dasthagirisaheb Y, Varvara G, Murmura G, Saggini A, Potalivo G, Caraffa A, et al. Vascular endothelial growth factor (VEGF), mast cells and inflammation. Int J Immunopathol Pharmacol. 2013;26:327-35 pubmed
    ..b>Mast cells can be activated by anti-IgE to release potent mediators of inflammation and can also respond to bacterial or ..
  34. Cabeza J, Acosta J, Ales E. Mechanisms of granule membrane recapture following exocytosis in intact mast cells. J Biol Chem. 2013;288:20293-305 pubmed publisher
    ..We studied exocytosis and endocytosis in mast cells with both perforated-patch and whole-cell configurations of the patch clamp technique using cell capacitance ..
  35. Gupta S, Duraiswamy B, Satishkumar M. Peritoneal mast cell stabilization potential of Pothos scandens L. Indian J Pharmacol. 2013;45:83-6 pubmed publisher
    ..To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts...
  36. Katwa P, Wang X, Urankar R, Podila R, Hilderbrand S, Fick R, et al. A carbon nanotube toxicity paradigm driven by mast cells and the IL-??/ST? axis. Small. 2012;8:2904-12 pubmed publisher
    ..b>Mast cells are critical for innate and adaptive immune responses, often modulating allergic and pathogenic conditions...
  37. Suurmond J, van Heemst J, van Heiningen J, Dorjée A, Schilham M, van der Beek F, et al. Communication between human mast cells and CD4(+) T cells through antigen-dependent interactions. Eur J Immunol. 2013;43:1758-68 pubmed publisher
    b>Mast cells (MCs) are immune cells residing in tissues where pathogens are first encountered. It has been indicated that MCs might also be involved in setting the outcome of T-cell responses...
  38. Sarchio S, Kok L, O Sullivan C, Halliday G, Byrne S. Dermal mast cells affect the development of sunlight-induced skin tumours. Exp Dermatol. 2012;21:241-8 pubmed publisher
    ..Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in ..
  39. Reber L, Marichal T, Galli S. New models for analyzing mast cell functions in vivo. Trends Immunol. 2012;33:613-25 pubmed publisher
    ..well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that contribute to disease or help to maintain health...
  40. Boes T, Levy D. Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells. Cephalalgia. 2012;32:924-31 pubmed publisher
    ..Intracranial mast cells (MCs) are likely to have a role in migraine headache genesis, and changes in the dural MC population might ..
  41. Woidacki K, Popovic M, Metz M, Schumacher A, Linzke N, Teles A, et al. Mast cells rescue implantation defects caused by c-kit deficiency. Cell Death Dis. 2013;4:e462 pubmed publisher
    ..kinase (c-Kit) and its ligand stem cell factor (SCF), with SCF known to be the most important growth factor for mast cells (MCs)...
  42. Nelissen S, Lemmens E, Geurts N, Kramer P, Maurer M, Hendriks J, et al. The role of mast cells in neuroinflammation. Acta Neuropathol. 2013;125:637-50 pubmed publisher
    b>Mast cells (MCs) are densely granulated perivascular resident cells of hematopoietic origin and well known for their pathogenetic role in allergic and anaphylactic reactions...
  43. Hepworth M, Daniłowicz Luebert E, Rausch S, Metz M, Klotz C, Maurer M, et al. Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines. Proc Natl Acad Sci U S A. 2012;109:6644-9 pubmed publisher
    b>Mast cells (MCs) are potent inflammatory cells that are distributed throughout mucosal barrier tissues and respond rapidly to pathogenic stimuli. During helminth infections, MCs play an important role as late-stage effectors...
  44. Rice L, Bax H, Russell L, Barrett V, Walton S, Deakin A, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013;704:49-57 pubmed publisher
    ..CRAC channels; GSK-5498A and GSK-7975A were tested to demonstrate their ability to inhibit mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species...
  45. Saleem S, Martin R, Morales J, Sturgill J, Gibb D, Graham L, et al. Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity. J Immunol. 2012;189:511-5 pubmed publisher
    ..brasiliensis infection. Intriguingly, both results were dependent on MDSC interaction with mast cells (MCs), as demonstrated by adoptive-transfer studies in MC-deficient (Kit(Wsh)(/)(Wsh)) mice...
  46. Paraskevopoulos G, Sifnaios E, Christodoulopoulos K, Mantopoulou F, Papakonstantis M, Sabaziotis D. Successful treatment of mastocytic anaphylactic episodes with reduction of skin mast cells after anti-IgE therapy. Eur Ann Allergy Clin Immunol. 2013;45:52-5 pubmed
    ..We describe a case of a patient with mastocytosis responsive clinically and patho-physiologically after anti-IgE treatment...
  47. Wu X, Zou Y, He X, Yuan R, Chen Y, Lan N, et al. Tumor-infiltrating mast cells in colorectal cancer as a poor prognostic factor. Int J Surg Pathol. 2013;21:111-20 pubmed publisher
    The purpose of this study is to investigate the clinical/prognostic significance of tumor-infiltrating mast cells (TIMs) in patients with colorectal cancer (CRC)...
  48. Ma Y, Kang H, Kim J, Garred P, Lee M, Lee B. Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells. BMB Rep. 2013;46:376-81 pubmed
    ..We investigate how mouse MBL-A or ficolin-A regulate mouse bone marrow-derived mast cells (mBMMCs)-derived inflammatory response against bacterial lipopolysaccharide (LPS) stimulation...
  49. Ashmole I, Duffy S, Leyland M, Morrison V, Begg M, Bradding P. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012;129:1628-35.e2 pubmed publisher
    Influx of extracellular Ca(2+) into human lung mast cells (HLMCs) is essential for the Fc?RI-dependent release of preformed granule-derived mediators and newly synthesized autacoids and cytokines...
  50. Hoffmann K, Xifró R, Hartweg J, Spitzlei P, Meis K, Molderings G, et al. Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells. Eur J Pharmacol. 2013;700:152-8 pubmed publisher
    The activation of adenosine A(2B) receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8...
  51. Norton J, Hayashi T, Crain B, Cho J, Miller L, Corr M, et al. Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. J Immunol. 2012;188:2977-80 pubmed publisher
    ..Mice deficient in mast cells, but not mice lacking lymphocytes, were resistant to NBP-induced inflammation, and reconstitution of these mice ..
  52. Won Jung H, Jung J, Weon Cho C, Kang J, Park Y. Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells. J Ethnopharmacol. 2012;142:684-93 pubmed publisher
    ..KOB03 is a polyherbal medicine consisting of five different herbs and has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic effect and mechanism remain unknown...
  53. Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto Sasaki T, Matsumoto K, et al. Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fc? receptor I and Fc? receptor II. Arthritis Rheum. 2013;65:109-19 pubmed publisher
    Substantial evidence suggests that human synovial mast cells (MCs) are involved in the pathogenesis of rheumatoid arthritis (RA)...