kupffer cells


Summary: Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.

Top Publications

  1. Golbar H, Izawa T, Murai F, Kuwamura M, Yamate J. Immunohistochemical analyses of the kinetics and distribution of macrophages, hepatic stellate cells and bile duct epithelia in the developing rat liver. Exp Toxicol Pathol. 2012;64:1-8 pubmed publisher
    Non-parenchymal cells in the liver consist mainly of Kupffer cells, hepatic stellate (HS) cells and cholangiocytes...
  2. Lee L, Kaizu T, Toyokawa H, Zhang M, Ross M, Stolz D, et al. Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats. Liver Transpl. 2011;17:1457-66 pubmed publisher
    ..b>Kupffer cells (KCs) play important roles in I/R injury; however, little is known about their changes during cold ..
  3. Seki S, Nakashima H, Nakashima M, Kinoshita M. Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells, and CD8 CD122 T cells. Clin Dev Immunol. 2011;2011:868345 pubmed publisher
    Mouse and human livers contain innate immune leukocytes, NK cells, NKT cells, and macrophage-lineage Kupffer cells. Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (?-galactocylceramide), ..
  4. Wojtalla A, Herweck F, Granzow M, Klein S, Trebicka J, Huss S, et al. The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2012;302:G873-87 pubmed publisher
    ..Thus the selective induction of cell death in HSCs proposes NADA as a novel antifibrogenic mediator...
  5. Yang H, Guo H, Fan K, Zhang B, Zhao L, Hou S, et al. Clearance of Propionibacterium acnes by kupffer cells is regulated by osteopontin through modulating the expression of p47phox. Mol Immunol. 2011;48:2019-26 pubmed publisher
    ..In this report, we revealed that OPN could affect the clearance of Propionibacterium acnes in kupffer cells. In a murine model of P...
  6. Anthony B, Ramm G, McManus D. Role of resident liver cells in the pathogenesis of schistosomiasis. Trends Parasitol. 2012;28:572-9 pubmed publisher
    ..part in this process, including hepatic stellate cells, which are responsible for collagen production, and Kupffer cells, the liver macrophages involved in both host protection and in pathology...
  7. Lau D, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, et al. Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection. Gastroenterology. 2013;144:402-413.e12 pubmed publisher
    ..Importantly, Kupffer cells were a local source of IFN that promoted basal expression of ISG in hepatocytes of nonresponders...
  8. Fisher J, McKenzie T, Lillegard J, Yu Y, Juskewitch J, Nedredal G, et al. Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure. J Surg Res. 2013;180:147-55 pubmed publisher
    ..Also, no cell type has been identified as the key mediator of the TLR4 pathway in ALF. This study examines the role of TLR4 and Kupffer cells (KCs) in the development of the SIRS following acetaminophen (APAP)-induced ALF.
  9. Nakashima H, Ogawa Y, Shono S, Kinoshita M, Nakashima M, Sato A, et al. Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/Fas-ligand-dependent hepatitis in hypercholesterolemic mice. PLoS ONE. 2013;8:e49339 pubmed publisher
    ..In addition, F4/80(+) Kupffer cells can be subclassified into CD68(+) subset with a phagocytosing capacity and CD11b(+) subset with a TNF-..

More Information


  1. Liu C, Tao Q, Sun M, Wu J, Yang W, Jian P, et al. Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. Lab Invest. 2010;90:1805-16 pubmed publisher
    ..In this study, we examined the apoptosis and activation of Kupffer cells (KCs) as well as their pathophysiological involvement in liver fibrosis process...
  2. Ikarashi M, Nakashima H, Kinoshita M, Sato A, Nakashima M, Miyazaki H, et al. Distinct development and functions of resident and recruited liver Kupffer cells/macrophages. J Leukoc Biol. 2013;94:1325-36 pubmed publisher
    Although mouse liver F4/80(+) Kupffer cells consist of cytokine-producing CD11b(+) cells and phagocytic CD68(+) cells, an undefined CD11b(-) CD68(-) subset (30%) also exists...
  3. Qiao Y, Qian J, Wang F, Ma Z, Wang Q. Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells. J Surg Res. 2014;187:653-9 pubmed publisher
    ..The purpose of the present study was to investigate the protective effect of butyrate preconditioning, if any, against hepatic I/R injury in rats and the underlying mechanisms involved...
  4. Fujiyoshi M, Ozaki M. Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases. J Hepatobiliary Pancreat Sci. 2011;18:13-22 pubmed publisher
    ..Regeneration is achieved by a complex interactive network consisting of liver cells (hepatocytes, Kupffer cells, sinusoidal endothelial cells, hepatic stellate cells, and stem cells) and extrahepatic organs (thyroid gland, ..
  5. Ioannou G, Haigh W, Thorning D, Savard C. Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis. J Lipid Res. 2013;54:1326-34 pubmed publisher
    ..Activated Kupffer cells aggregated around dead hepatocytes that included strongly birefringent cholesterol crystals, forming "..
  6. Ma H, Zhao S, Ma Y, Guo X, Han D, Jia Y, et al. Susceptibility of chicken Kupffer cells to Chinese virulent infectious bursal disease virus. Vet Microbiol. 2013;164:270-80 pubmed publisher
    ..b>Kupffer cells became "swollen-like" and the electron-density of their cytoplasm was lower than that of cells in ..
  7. Duwaerts C, Gehring S, Cheng C, Van Rooijen N, Gregory S. Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury. Liver Int. 2013;33:255-65 pubmed publisher
    ..Although resident hepatic macrophages (Kupffer cells) are frequently implicated in disease progression, most studies fail to differentiate the contribution of ..
  8. Neunaber C, Oestern S, Andruszkow H, Zeckey C, Mommsen P, Kutter D, et al. Cytokine productive capacity of alveolar macrophages and Kupffer cells after femoral fracture and blunt chest trauma in a murine trauma model. Immunol Lett. 2013;152:159-66 pubmed publisher
    ..Therefore, we investigated alterations of the cytokine productive capacity of alveolar macrophages (AM) and Kupffer cells (KC) after femoral fracture stabilized with intramedullary pin with or without blunt chest trauma.
  9. Byun J, Suh Y, Yi H, Lee Y, Jeong W. Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. J Hepatol. 2013;58:342-9 pubmed publisher
    The important function of toll-like receptor (TLR) 4 in Kupffer cells and hepatic stellate cells (HSCs) has been well documented in alcoholic liver injury. However, little is known about the role of TLR3...
  10. Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012;122:3476-89 pubmed publisher
    ..pathogenic role of IL-1 signaling in ALD was attributable to the activation of the inflammasome in BM-derived Kupffer cells. Importantly, in vivo intervention with a recombinant IL-1Ra blocked IL-1 signaling and markedly attenuated ..
  11. Lailson Brito J, Cruz R, Dorneles P, Andrade L, Azevedo A, Fragoso A, et al. Mercury-selenium relationships in liver of Guiana dolphin: the possible role of Kupffer cells in the detoxification process by tiemannite formation. PLoS ONE. 2012;7:e42162 pubmed publisher
    ..Accumulation of Se-Hg amorphous crystals in Kupffer Cells was demonstrated through ultra-structural analysis, which shows that Guiana dolphin is capable of carrying out ..
  12. Dixon L, Berk M, Thapaliya S, Papouchado B, Feldstein A. Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab Invest. 2012;92:713-23 pubmed publisher
    ..The conclusion of this study is that it uncovers a novel role for caspase-1 in inflammation and fibrosis during NASH development...
  13. Tseng M, Lu X, Duan X, Hardas S, Sultana R, Wu P, et al. Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria. Toxicol Appl Pharmacol. 2012;260:173-82 pubmed publisher
    ..We observed acute ceria nanoparticle sequestration by Kupffer cells with subsequent bioretention in parenchymal cells as well...
  14. Kojima S, Negishi Y, Tsukimoto M, Takenouchi T, Kitani H, Takeda K. Purinergic signaling via P2X7 receptor mediates IL-1? production in Kupffer cells exposed to silica nanoparticle. Toxicology. 2014;321:13-20 pubmed publisher
    ..b>Kupffer cells are macrophages resident in the liver, and play important roles in liver inflammation induced by various toxic ..
  15. Feng M, Wang Q, Zhang F, Lu L. Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury. Int Immunopharmacol. 2012;12:189-96 pubmed publisher
    ..TNF-? expression, promoted transcription of interleukin-10 (IL-10), and elevated phosphorylation of SMAD3 in Kupffer cells (KCs). Furthermore, inhibition of TGF-? signaling by anti-TGF-? abolished the effects on KCs...
  16. Aziz Seible R, Lee S, Kharbanda K, McVicker B, Casey C. Ethanol feeding potentiates the pro-inflammatory response of Kupffer cells to cellular fibronectin. Alcohol Clin Exp Res. 2011;35:717-25 pubmed publisher
    ..We propose that cFn directly stimulates Kupffer cells (KCs), which are involved in the early response to tissue damage, to produce factors that enhance the ..
  17. Kinoshita M, Uchida T, Sato A, Nakashima M, Nakashima H, Shono S, et al. Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. J Hepatol. 2010;53:903-10 pubmed publisher
    Liver Kupffer cells have been suggested to be heterogeneous macrophage lineage cells. We explored this possibility by classifying the mouse Kupffer cells into subpopulations and characterizing them by their phenotype and function.
  18. Shiozaki M, Hayakawa N, Shibata M, Koike M, Uchiyama Y, Gotow T. Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice. Histochem Cell Biol. 2011;136:475-89 pubmed publisher
    ..Cathepsin D expression was less in hepatocytes but enhanced in Kupffer cells, which were increased in number and size with more numerous lysosome-related profiles...
  19. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, et al. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011;286:1436-44 pubmed publisher
    Activation of Kupffer cells (KCs) by gut-derived lipopolysaccharide (LPS) and Toll-Like Receptors 4 (TLR4)-LPS-mediated increase in TNF? production has a central role in the pathogenesis of alcoholic liver disease...
  20. Holland Fischer P, Grønbæk H, Sandahl T, Moestrup S, Riggio O, Ridola L, et al. Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS. Gut. 2011;60:1389-93 pubmed publisher
    Hepatic macrophages (Kupffer cells) undergo inflammatory activation during the development of portal hypertension in experimental cirrhosis; this activation may play a pathogenic role or be an epiphenomenon...
  21. Choi J, Chu S, Ahn K, Kim S, Ji J, Won J, et al. C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides. Mol Cells. 2011;32:325-31 pubmed publisher
    ..We examined whether exogenous cell-permeable C(6)-ceramide enhances the phagocytic activity of Kupffer cells (KCs) and affects the level of cellular ceramides...
  22. Wang Z, Lv H, Song S, Shen X, Yang L, Yu W. Emulsified isoflurane preconditioning protects isolated rat Kupffer cells against hypoxia/reoxygenation-induced injury. Int J Med Sci. 2013;10:286-91 pubmed publisher
    To investigate the protective effect of emulsified isoflurane (EI) preconditioning on isolated rat Kupffer cells (KCs) subjected to hypoxia/reoxygenation (H/R)-induced injury.
  23. Li Z, Kruijt J, van der Sluis R, Van Berkel T, Hoekstra M. Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells. Physiol Genomics. 2013;45:268-75 pubmed publisher
    ..Parenchymal liver cells (hepatocytes) and liver endothelial and Kupffer cells were isolated from virgin female C57BL/6 wild-type mice using collagenase perfusion and counterflow ..
  24. KINLOCH R, Lee C, Van Rooijen N, Morgan E. Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen. Biochem Pharmacol. 2011;82:312-21 pubmed publisher
    ..Uninfected mice injected with clodronate liposomes had a significantly reduced number of Kupffer cells in their livers. Infection increased the Kupffer cell count, which was attenuated by clodronate treatment...
  25. Wong C, Jenne C, Petri B, Chrobok N, Kubes P. Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol. 2013;14:785-92 pubmed publisher
    Through the use of intravital imaging of the liver, we demonstrate a collaborative role for platelets with Kupffer cells (KCs) in eradicating blood-borne bacterial infection...
  26. Chen Y, Tong H, Zhang X, Tang L, Pan Z, Liu Z, et al. Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats. J Tradit Chin Med. 2013;33:243-9 pubmed
    ..To evaluate the effects of Xuebijing (XBJ) injection in heat stroke (HS) rats and to investigate the mechanisms underlying these effects...
  27. Liu W, Hou Y, Chen H, Wei H, Lin W, Li J, et al. Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies. Proteomics. 2011;11:3556-64 pubmed publisher
    ..we described could simultaneously isolate population of hepatocytes (HCs), hepatic stellate cells (HSCs), Kupffer cells (KCs) and liver sinusoidal endothelial cells (LSECs) by a combination of collagenase-based density gradient ..
  28. Luan X, Liao W, Lai X, He Y, Liu Y, Gong J, et al. Dynamic changes of indoleamine 2,3-dioxygenase of Kupffer cells in rat liver transplant rejection and tolerance. Transplant Proc. 2012;44:1045-7 pubmed publisher
    To study the dynamic changes and the immunologic role of indoleamine 2, 3-dioxygenase (IDO) in Kupffer cells (KCs) after rat liver transplantation.
  29. Luan X, Liu Y, Li M. The role of CD14 and Toll-like receptor 4 of Kupffer cells in hepatic ischemia-reperfusion injury in rats. Transplant Proc. 2012;44:937-41 pubmed publisher
    The objective of this study was to study the role of CD14 and Toll-like receptor 4 (TLR4) in Kupffer cells (KCs) on ischemia reperfusion injury (IRI) in rat liver grafts.
  30. Leroux A, Ferrere G, Godie V, Cailleux F, Renoud M, Gaudin F, et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J Hepatol. 2012;57:141-9 pubmed publisher
    ..As macrophages may be involved in the lymphocyte homing, we studied the role of lipids in determining the phenotype of Kupffer cells (KCs) at the stage of steatosis.
  31. Lyoumi S, Abitbol M, Rainteau D, Karim Z, Bernex F, Oustric V, et al. Protoporphyrin retention in hepatocytes and Kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model. Gastroenterology. 2011;141:1509-19, 1519.e1-3 pubmed publisher
    ..We characterized protoporphyrin-IX (PPIX)-linked hepatobiliary disease in BALB/c and C57BL/6 (Fechm1Pas) mice with mutations in ferrochelatase as models for EPP...
  32. Wei S, Huang Q, Li J, Liu Z, You H, Chen Y, et al. Taurine attenuates liver injury by downregulating phosphorylated p38 MAPK of Kupffer cells in rats with severe acute pancreatitis. Inflammation. 2012;35:690-701 pubmed publisher
    ..p38 mitogen-activated protein kinase (p38 MAPK) expression and nuclear factor-?B (NF-?B) activity of Kupffer cells (KCs) were significantly higher in the SAP group, but taurine pretreatment inhibited the total and ..
  33. Wen S, Ager E, Christophi C. Bimodal role of Kupffer cells during colorectal cancer liver metastasis. Cancer Biol Ther. 2013;14:606-13 pubmed publisher
    b>Kupffer cells (KCs) are resident liver macrophages that play a crucial role in liver homeostasis and in the pathogenesis of liver disease...
  34. Huang H, Chen H, Evankovich J, Yan W, Rosborough B, Nace G, et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J Immunol. 2013;191:2665-79 pubmed publisher
    ..This mechanism is operant in resident liver Kupffer cells, which drive innate immune responses after I/R injury by recruiting additional cell types, including ..
  35. Cubero F, Nieto N. Arachidonic acid stimulates TNF? production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2012;303:G228-39 pubmed publisher
    b>Kupffer cells are a key source of mediators of alcohol-induced liver damage such as reactive oxygen species, chemokines, growth factors, and eicosanoids...
  36. Prill J, Espenlaub S, Samen U, Engler T, Schmidt E, Vetrini F, et al. Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells. Mol Ther. 2011;19:83-92 pubmed publisher
    ..Kupffer cell scavenging while delivery to peripheral tissues or tumors could be improved if both scavenging by Kupffer cells and uptake by hepatocytes were blocked...
  37. Chen X, Sun L, Guo F, Wang F, Liu S, Liang X, et al. High-mobility group box-1 induces proinflammatory cytokines production of Kupffer cells through TLRs-dependent signaling pathway after burn injury. PLoS ONE. 2012;7:e50668 pubmed publisher
    b>Kupffer cells (KCs) were a significant source of cytokine release during the early stage of severe burns. High mobility group box protein 1 (HMGB1) was recently identified as a new type of proinflammatory cytokine...
  38. Kim T, Lee S, Lee S. Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction. FEBS J. 2011;278:2307-17 pubmed publisher
    The present study aimed to determine the role of Kupffer cells (KCs) in cytochrome P450 (CYP) isozyme activity and the expression of its gene during polymicrobial sepsis...
  39. Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, et al. TNF?-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. PLoS Pathog. 2013;9:e1003096 pubmed publisher
    ..In contrast, Kupffer cells and inflammatory monocytes contributed substantially to liver destruction during ALA, and tissue damage was ..
  40. Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology. 2011;54:2185-97 pubmed publisher
    ..MCP-1 was increased in Kupffer cells (KCs) as well as hepatocytes of alcohol-fed mice...
  41. Mandal P, Roychowdhury S, Park P, Pratt B, Roger T, Nagy L. Adiponectin and heme oxygenase-1 suppress TLR4/MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure. J Immunol. 2010;185:4928-37 pubmed publisher
    ..ethanol feeding, LPS-stimulated expression of IFN-? and CXCL10 mRNA was increased in primary cultures of Kupffer cells compared with pair-fed control mice...
  42. Schwer C, Stoll P, Pietsch U, Stein P, Laqua J, Goebel U, et al. Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver. Int J Biochem Cell Biol. 2010;42:1876-83 pubmed publisher
    ..was to characterize the respective signal transduction pathway and in particular to elucidate the role of Kupffer cells in this context. Rats were treated with or without sevoflurane...
  43. Inokuchi S, Tsukamoto H, Park E, Liu Z, Brenner D, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011;35:1509-18 pubmed publisher
    ..Increased LPS in the portal vein stimulates Kupffer cells through Toll-like receptor (TLR) 4 in the liver...
  44. Szabo G, Petrasek J, Bala S. Innate immunity and alcoholic liver disease. Dig Dis. 2012;30 Suppl 1:55-60 pubmed publisher
    ..Our recent results suggest that inflammasome and caspase-1 activation occur in ALD and that IL-1 significantly contributes to both steatosis and inflammation in the liver in ALD...
  45. Sitia G, Iannacone M, Aiolfi R, Isogawa M, Van Rooijen N, Scozzesi C, et al. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog. 2011;7:e1002061 pubmed publisher
    b>Kupffer cells (KCs) are widely considered important contributors to liver injury during viral hepatitis due to their pro-inflammatory activity...
  46. Radi Z, Koza Taylor P, Bell R, Obert L, Runnels H, Beebe J, et al. Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury. Am J Pathol. 2011;179:240-7 pubmed publisher
    ..the survival and proliferation of monocytes and the differentiation of monocytes into macrophages, including Kupffer cells (KCs) in the liver...
  47. Fang X, Zou S, Zhao Y, Cui R, Zhang W, Hu J, et al. Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor ? expression by releasing cytokines. Arch Toxicol. 2012;86:1515-25 pubmed publisher
    b>Kupffer cells (KCs) have been demonstrated to play a role in the regulation of intra-hepatic lipid metabolism through the synthesis and secretion of biologically active products...
  48. Iwaisako K, Haimerl M, Paik Y, Taura K, Kodama Y, Sirlin C, et al. Protection from liver fibrosis by a peroxisome proliferator-activated receptor ? agonist. Proc Natl Acad Sci U S A. 2012;109:E1369-76 pubmed publisher
  49. Schulz C, Gomez Perdiguero E, Chorro L, Szabo Rogers H, Cagnard N, Kierdorf K, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336:86-90 pubmed publisher
    ..macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently ..
  50. Ohara Y, Oda T, Yamada K, Hashimoto S, Akashi Y, Miyamoto R, et al. Effective delivery of chemotherapeutic nanoparticles by depleting host Kupffer cells. Int J Cancer. 2012;131:2402-10 pubmed publisher
    ..to more effectively deliver therapeutic nanoparticles to target regions in vivo, host RES, especially Kupffer cells in the liver, have been depleted ahead of drug administration...
  51. Liu T, Li L, Fu C, Liu H, Chen D, Tang F. Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles. Biomaterials. 2012;33:2399-407 pubmed publisher
    ..We also found that activated kupffer cells (KCs) played a key role in the liver damage caused by SNs similar to alveolar macrophage in the process of ..
  52. Bhogal R, Curbishley S, Weston C, Adams D, Afford S. Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation. Liver Transpl. 2010;16:1303-13 pubmed publisher
    ..Much work has been focused on Kupffer cells or liver resident macrophages with respect to the generation of ROS during IRI...
  53. Wan J, Benkdane M, Teixeira Clerc F, Bonnafous S, Louvet A, Lafdil F, et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology. 2014;59:130-42 pubmed publisher
    ..IL10 secreted by M2 KCs promoted selective M1 death by a mechanism involving activation of arginase in high inducible nitric oxide synthase-expressing M1 KCs. In alcohol-exposed mice, neutralization of IL10 impaired M1 apoptosis...