histiocytes

Summary

Summary: Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).

Top Publications

  1. Wada N, Ikeda J, Kohara M, Ogawa H, Hino M, Fukuhara S, et al. Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group. Virchows Arch. 2009;455:285-93 pubmed publisher
    ..of this study was to clarify whether diffuse large B-cell lymphoma (DLBCL) with a high number of epithelioid histiocytes (DLBCL-EH) could have distinctive clinicopathological characteristics...
  2. Ruggiero A, Attinà G, Maurizi P, Mule A, Tarquini E, Barone G, et al. Rosai-Dorfman disease: two case reports and diagnostic role of fine-needle aspiration cytology. J Pediatr Hematol Oncol. 2006;28:103-6 pubmed
    ..Long-term follow-up is necessary to observe the complete regression of the massive lymphadenopathy. However, specific therapy is available and should be limited to patients with compressive symptoms or extranodal disease...
  3. Pileri S, Falini B, Delsol G, Stein H, Baglioni P, Poggi S, et al. Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1 + with a high content of reactive histiocytes). Histopathology. 1990;16:383-91 pubmed
    We describe 13 cases of a peculiar lymphoid tumour containing very large numbers of reactive histiocytes. The tumours occurred in young patients (mean age 14.8 y) who presented with systemic symptoms and superficial lymphadenopathy...
  4. Pileri S, Grogan T, Harris N, Banks P, Campo E, Chan J, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002;41:1-29 pubmed
    Neoplasms of histiocytes and dendritic cells are rare, and their phenotypic and biological definition is incomplete...
  5. Kumakura S, Ishikura H, Tsumura H, Kobayashi S. Phagocytosis of terminally differentiated acute promyelocytic leukemia cells by marrow histiocytes during treatment with all-trans retinoic acid. Leuk Lymphoma. 2003;44:2147-50 pubmed
    ..Here, we documented the elimination of terminally differentiated APL cells by histiocytes in bone marrow during differentiation induction therapy...
  6. Maldonado A, He L, Game B, Nareika A, Sanders J, London S, et al. Pre-exposure to high glucose augments lipopolysaccharide-stimulated matrix metalloproteinase-1 expression by human U937 histiocytes. J Periodontal Res. 2004;39:415-23 pubmed
  7. Tomioka M, Ueki K, Nakahashi H, Isoda A, Kuroiwa T, Kaneko Y, et al. Widespread crystalline inclusions affecting podocytes, tubular cells and interstitial histiocytes in the myeloma kidney. Clin Nephrol. 2004;62:229-33 pubmed
    ..Infiltrations of histiocytes with expanded cytoplasm were also seen in the interstitium of the kidney and bone marrow...
  8. Goto H, Inaba M, Kobayashi K, Imanishi Y, Kumeda Y, Inui K, et al. Successful treatment of multicentric reticulohistiocytosis with alendronate: evidence for a direct effect of bisphosphonate on histiocytes. Arthritis Rheum. 2003;48:3538-41 pubmed
    ..Skin and synovial biopsies showed heavy infiltration with tartrate-resistant acid phosphatase-positive histiocytes and multinucleated giant cells...
  9. Munichor M, Cohen H, Volpin G, Kerner H, Iancu T. Chromium-induced lymph node histiocytic proliferation after hip replacement. A case report. Acta Cytol. 2003;47:270-4 pubmed
    ..To our knowledge, this is the first report of chromium-related lymph node metallosis diagnosed by fine needle aspiration...

More Information

Publications62

  1. Sasaki Y, Tanaka M, Kudo H. Differentiation between ulcerative colitis and Crohn's disease by a quantitative immunohistochemical evaluation of T lymphocytes, neutrophils, histiocytes and mast cells. Pathol Int. 2002;52:277-85 pubmed
    ..3)'; the criteria had values for sensitivity and specificity exceeding 95%. The immunohistochemical criteria distinguishing UC from CD may help to confirm the diagnosis in patients with ambiguous endoscopic and histological diagnosis...
  2. Pileri S, Facchetti F, Ascani S, Sabattini E, Poggi S, Piccioli M, et al. Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy. Am J Pathol. 2001;159:915-24 pubmed
    ..In KL and Kikuchi-like lupus erythematosus lymphadenopathies, 25 to 75% of CD68(+) histiocytes co-expressed MPO. This did not occur in nonnecrotizing lymphadenitidies and accessory cell neoplasms...
  3. Bejarano P, Aranda Michel J, Fenoglio Preiser C. Histochemical and immunohistochemical characterization of foamy histiocytes (muciphages and xanthelasma) of the rectum. Am J Surg Pathol. 2000;24:1009-15 pubmed
    Despite being relatively common in the rectum, foamy histiocytes have received scant attention as to the antecedent lesion that causes them to form or their histologic characterization on the types of muco-substances they accumulate...
  4. Flavell D, Jones D, Wright D. Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody. J Histochem Cytochem. 1987;35:1217-26 pubmed
    A mouse monoclonal antibody (MAC 387) with specificity for monocytes and tissue histiocytes was produced by immunization of a BALB/c mouse with peripheral blood monocyte components derived by affinity chromatography of detergent-..
  5. Busfield B, Anderson L. Sterile pretibial abscess after anterior cruciate reconstruction from bioabsorbable interference screws: a report of 2 cases. Arthroscopy. 2007;23:911.e1-4 pubmed
    ..To our knowledge, this is the first case report of a local reaction to poly-L-lactic acid bioabsorbable interference screws after anterior cruciate ligament reconstruction...
  6. Demicco E, Rosenberg A, Bjornsson J, Rybak L, Unni K, Nielsen G. Primary Rosai-Dorfman disease of bone: a clinicopathologic study of 15 cases. Am J Surg Pathol. 2010;34:1324-33 pubmed publisher
    ..demonstrated the classic features of RDD and consisted of a mixed inflammatory infiltrate with numerous large histiocytes with abundant eosinophilic cytoplasm which exhibited emperipolesis...
  7. Lee W, Kim S, Moon H, Choe Y, Park S, Lee H, et al. Pulmonary crystal-storing histiocytoma in a patient without a lymphoproliferative disorder. Am J Med Sci. 2009;338:421-4 pubmed publisher
    Pulmonary crystal-storing histiocytoma is a very rare disorder and is characterized by infiltration of histiocytes with intracytoplasmic accumulation of crystallized immunoglobulins...
  8. Andreopoulos A, Yiakoumis X, Antoniou T, Andreopoulos G, Konstantopoulos K, Pangalis G, et al. Primary adult-onset macrophage activation syndrome with multisystemic tissue phagocytosis. Int J Hematol. 2007;86:394-6 pubmed publisher
    The histiocyte disorders are divided into the following 3 categories according to the specific lineage of the histiocytes involved and their biological behavior: the dendritic cell-related disorders, which include Langerhans cell ..
  9. Payne S, Kim S, Das K, Mirani N. A 36-year-old woman with a unilateral breast mass. Necrotizing granulomatous mastitis secondary to budding yeast forms morphologically consistent with Histoplasma capsulatum. Arch Pathol Lab Med. 2006;130:e1-2 pubmed
  10. Oh C, Ivan D, Curry J, Ellis R, Gerber H, Duvic M, et al. A case of indeterminate dendritic cell tumor presenting with leonine facies. J Cutan Pathol. 2016;43:158-63 pubmed publisher
    ..Indeterminate dendritic cell tumor is an extremely rare neoplastic proliferation of dendritic cells that share immunophenotypic features of Langerhans cells and macrophages but lack Birbeck granules and Langerin expression...
  11. Gulwani H, Bhalla S, Srivastava A. Isolated lacrimal gland involvement in Rosai-Dorfman-Destombes disease. Indian J Ophthalmol. 2008;56:507-9 pubmed
    ..with massive lymphadenopathy) disease is an uncommon disease characterized by benign proliferation of histiocytes, with painless lymph node enlargement and frequent extranodal disease...
  12. Andreu C, Yat Wah P, Fraga J, Olivera M, Caballero P. [Necrotic lipoma of the posterior mediastinum]. Arch Bronconeumol. 2008;44:641-4 pubmed
    ..Areas with a higher fat density are suggestive of liposarcoma. We describe a case of lipoma in the posterior mediastinum that contained solid areas on computed tomography. Histology showed that these areas were fat necrosis...
  13. Kan E, Levy I, Benharroch D. Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy. Virchows Arch. 2009;455:337-41 pubmed publisher
    ..However, the histopathologic changes are probably not related with Epstein-Barr virus-induced immunosuppression...
  14. Danzer E, Ernst L, Rintoul N, Johnson M, Adzick N, Flake A. In utero meconium passage in fetuses and newborns with myelomeningocele. J Neurosurg Pediatr. 2009;3:141-6 pubmed publisher
    ..The authors retrospectively investigated whether midgestational fetal myelomeningocele (fMMC) repair alters intrauterine meconium exposure...
  15. Miyabe Y, Murata Y, Baba Y, Ito E, Nagasaka K. Successful treatment of cyclosporine-A-resistant cytophagic histiocytic panniculitis with tacrolimus. Mod Rheumatol. 2011;21:553-6 pubmed publisher
    ..Treatment with high doses of prednisolone combined with cyclosporine A (CsA) was not effective enough. However, after changing CsA to tacrolimus (TAC), CHP improved. Our case demonstrates that TAC may be a novel therapy for CHP...
  16. Höhler F, Dietl K, Novák K, Giedl J, Paetzel C. Mesenteric histiocytosis or only an inflammatory infiltration of histiocytes? A case report from a surgical point of view. Int Surg. 2012;97:260-5 pubmed publisher
  17. Torrelo A, Vera A, Portugués M, De Prada I, Sanz A, Colmenero I, et al. Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. Pediatr Dermatol. 2007;24:211-5 pubmed
    ..Both patients had congenital immunodeficiency. This skin condition of the newborn, with distinct clinical and histopathologic features, is a manifestation of immunodeficiency that has not been previously described...
  18. Tresserra F, Castella M, Fabra G, Angeles Martínez M, Dominguez M, Fernandez Cid C, et al. Lymphohistiocytoid mesothelioma of the pleura: a case report with cytological findings. Diagn Cytopathol. 2013;41:546-9 pubmed publisher
    ..Its cytological diagnosis is difficult. We present a case of a 67-year-old female with lymphohistiocytoid mesothelioma involving the left pleura. The cytological, histological, and immunohistochemical features are discussed...
  19. Oda Y, Urushidani Y, Ooi S, Endoh A, Nakamura R, Adachi K, et al. Hemophagocytic lymphohistiocytosis in a rheumatoid arthritis patient treated with infliximab. Intern Med. 2012;51:655-7 pubmed
    ..Bone marrow aspiration showed proliferation of histiocytes with hemophagocytosis...
  20. Cavazza A, Rossi G, Barbareschi M, Damiani S, Cancellieri A, Murer B. [Diagnostic utility of macrophages in interstitial lung disease]. Pathologica. 2006;98:211-23 pubmed
  21. Le B, Truex R. 29 year-old male with seizure and syncope. Intracerebral Langerhans cell histiocytosis. Brain Pathol. 2013;23:363-4 pubmed publisher
    ..This report presents a case of an intra-axial LCH in a 29 year-old male who, following this diagnosis, was found to have multiple pulmonary lesions on imaging, attributed to the same disease process...
  22. Prakash S, Fountaine T, Raffeld M, Jaffe E, Pittaluga S. IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. Am J Surg Pathol. 2006;30:585-92 pubmed
    ..IgD positivity may represent an additional useful marker in the diagnosis of NLPHL...
  23. Wahba M. Case report of intracranial Rosai-Dorfman disease. Hosp Pract (1995). 2013;41:83-6 pubmed publisher
  24. Dorfman D, Hornick J, Shahsafaei A, Freeman G. The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. Hum Pathol. 2010;41:1486-94 pubmed publisher
    ..We conclude that histiocytic and dendritic cell neoplasms consistently express TIM-3 and TIM-4 and that these molecules are new markers of neoplasms derived from histiocytic and dendritic cells...
  25. Tousseyn T, De Wolf Peeters C. T cell/histiocyte-rich large B-cell lymphoma: an update on its biology and classification. Virchows Arch. 2011;459:557-63 pubmed publisher
    ..characterized by less than 10% of large neoplastic B cells in a background of abundant T cells and frequently histiocytes. Differentiating THRLBCL from other lymphoproliferative disorders such as Nodular Lymphocyte Predominant ..
  26. Devirgiliis V, Panasiti V, Borroni R, Rossi M, Curzio M, Riggio R, et al. Cutaneous cryptococcosis in a patient affected by chronic lymphocytic leukaemia: a case report. Int J Immunopathol Pharmacol. 2008;21:463-6 pubmed
    ..We report a case of cutaneous cryptococcosis in a patient affected by chronic lymphocytic leukaemia...
  27. Deshayes E, Le Berre J, Jouanneau E, Vasiljevic A, Raverot G, Seve P. 18F-FDG PET/CT findings in a patient with isolated intracranial Rosai-Dorfman disease. Clin Nucl Med. 2013;38:e50-2 pubmed publisher
    ..Stereotaxic hypothalamic lesion biopsy showed histiocytic proliferation positive for S100 protein and CD68, but negative for CD1a, typical for RDD. ¹?F-FDG PET/CT 4 months later demonstrated increased hypothalamic metabolic activity...
  28. Aouba A, Larousserie F, Le Guern V, Martin A, Guillevin L. Spumous histiocytic oligoarthritis coexisting with systemic Langerhans' cell histiocytosis: case report and literature review. Joint Bone Spine. 2009;76:701-4 pubmed publisher
    ..Both entities regressed under cladribine, with only mild relapses of the non-Langerhans' cell histiocytosis involvements...
  29. Jalil J, Dar N, Shafique M. Rosai Dorfman disease--a rare entity report of two cases with nodal and extranodal involvement. J Pak Med Assoc. 2008;58:338-40 pubmed
  30. Hindupur S. Hemophagocytosis in hemophagocytic lymphohistiocytosis. Am J Hematol. 2005;80:299-300 pubmed
  31. Kraeft S, Honig M, Krishnamurthy S. Emperipolesis in the cerebrospinal fluid from a patient with Rosai-Dorfman disease. Diagn Cytopathol. 2008;36:67-8 pubmed
  32. Mebazaa A, Trabelsi S, Denguezli M, Sriha B, Belajouza C, Nouira R. Extensive purely cutaneous Rosai-Dorfman disease responsive to acitretin. Int J Dermatol. 2007;46:1208-10 pubmed
  33. Malur P, Bannur H, Kodkany S. Orbital Rosai-Dorfman disease: report of a case with fine needle aspiration cytology and histopathology. Acta Cytol. 2007;51:581-2 pubmed
    ..Orbital involvement in the absence of lymphadenopathy is relatively uncommon...
  34. Alatassi H, Ray M, Galandiuk S, Sahoo S. Rosai-Dorfman disease of the gastrointestinal tract: report of a case and review of the literature. Int J Surg Pathol. 2006;14:95-9 pubmed
    ..It is characterized by a proliferation of distinctive histiocytes in the lymph nodes and/or extranodal sites. Involvement of the gastrointestinal tract is rare...
  35. Kobayashi T, Ueda M, Nishino T, Bamba M, Echigo T, Oka H, et al. Langerhans cell histiocytosis of the skull on cytologic squash preparations. Diagn Cytopathol. 2007;35:154-7 pubmed
    ..smears were cellular and demonstrated a mixed population of small, mature lymphocytes, eosinophils, and a high histiocytes content. The histiocytes occurred as isolated or loosely cohesive and clustered...
  36. Acevedo R, Gil D, Del Campo J, Bracho G, Valdés Y, Perez O. The adjuvant potential of synthetic alkylglycerols. Vaccine. 2006;24 Suppl 2:S2-32-3 pubmed
    ..These results indicate that synthetic AGs are effective adjuvants for the standardized antigen, Ova...
  37. Cury J, Coelho R, Franco M, Srougi M. Renal parenchymal malacoplakia with pleural effusion. Clinics (Sao Paulo). 2007;62:87-8 pubmed
  38. Tel A, Spinzia A, Boggio M. Diffuse tenosynovial giant cell tumour of the temporomandibular joint. Int J Oral Maxillofac Surg. 2012;41:321-3 pubmed publisher
    ..Only three cases of TGCT-D have been described in the literature. This report presents a case of TGCT-D in the temporomandibular joint...
  39. Ghoufi L, Ortonne N, Ingen Housz Oro S, Barhoumi W, Begon E, Haioun C, et al. Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant: A Comparative Series of 62 Patients. Medicine (Baltimore). 2016;95:e3033 pubmed publisher
    ..A complete hematological assessment is mandatory at diagnosis, and monitoring blood cell counts should be recommended for at least 6 months after the diagnosis of H-SS. ..
  40. El Khoury J, Kurban M, Abbas O. Elastophagocytosis: underlying mechanisms and associated cutaneous entities. J Am Acad Dermatol. 2014;70:934-44 pubmed publisher
    Elastophagocytosis is the phagocytosis of elastic fibers that can microscopically be seen in the cytoplasm of histiocytes, multinucleated giant cells, or both...
  41. Kir G, Yılmaz M, Cetiner H, Gocmen A, Alptekin F. Significance of foamy histiocytes in cervical smears from postmenopausal women. Acta Cytol. 2014;58:42-6 pubmed publisher
    To determine the significance of the presence of foamy histiocytes (FH) in postmenopausal cervicovaginal smears for the detection of endometrial carcinomas (EC).
  42. Loo E, Medeiros L, Aladily T, Hoehn D, Kanagal Shamanna R, Young K, et al. Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases. Am J Surg Pathol. 2013;37:1290-7 pubmed publisher
    ..The microenvironment of these lesions depicted a predominance of T-regulatory cells and M2 histiocytes. Clinical follow-up data were available for 7 patients, with a median posttreatment period of 27 months (range, ..
  43. Akyay A, Celkan T, Iskender G, Tukun A, Ogan C, Olcay L. Two acute myeloblastic leukemia cases concomitant with hemophagocytic lymphohistiocytosis and review of the literature. Ann Clin Lab Sci. 2013;43:85-90 pubmed
    ..Our cases and cases in the literature highlight the high mortality rate of leukemia associated with HLH and the need for further investigation for the most appropriate therapy...
  44. Ganau M, Ennas F, Bellisano G, Ganau L, Ambu R, Faa G, et al. Synovial cysts of the lumbar spine--pathological considerations and surgical strategy. Neurol Med Chir (Tokyo). 2013;53:95-102 pubmed
    ..True synovial cysts have a thick wall lined by synovial cells, containing granulation tissue, numerous histiocytes, and giant cells...
  45. Haroche J, Amoura Z, Trad S, Wechsler B, Cluzel P, Grenier P, et al. Variability in the efficacy of interferon-alpha in Erdheim-Chester disease by patient and site of involvement: results in eight patients. Arthritis Rheum. 2006;54:3330-6 pubmed
    ..non-Langerhans form of histiocytosis of unknown origin, characterized by infiltration of tissues by spumous histiocytes. ECD features heterogeneous systemic manifestations, and the general prognosis remains poor despite various ..
  46. van Gelder M, Bot F. [Kikuchi's histiocytic necrotising lymphadenitis: a benign disorder--not to be confused with malignant lymphoma]. Ned Tijdschr Geneeskd. 2006;150:2099-103 pubmed
  47. Chen Y, Chao C, Liu H. Cutaneous plasma cell granuloma: report of a case with novel histologic and immunohistochemical findings. Int J Dermatol. 2009;48:409-11 pubmed publisher
    ..At higher power, a mixed inflammatory infiltrate composed of histiocytes, foamy histiocytes (Fig. 2b), lymphocytes, and abundant plasma cells (Fig. 2c) with Russell bodies was revealed...
  48. Mallik M, Kapila K, Das D, Haji B, Anim J. Cytomorphology of hyaline-vascular Castleman's disease: a diagnostic challenge. Cytopathology. 2007;18:168-74 pubmed
    ..The cytomorphological findings in three histopathologically documented cases of hyaline-vascular CD were evaluated to a set of cytomorphological criteria which could help in the identification of this condition on aspirate smears...
  49. Handerson T, Berger A, Harigopol M, Rimm D, Nishigori C, Ueda M, et al. Melanophages reside in hypermelanotic, aberrantly glycosylated tumor areas and predict improved outcome in primary cutaneous malignant melanoma. J Cutan Pathol. 2007;34:679-86 pubmed
    ..This study further investigated associations between melanophages and beta1,6-branched oligosaccharides and their potential contributions to patient outcome...
  50. Sadat Ali M, Azzam Q, Bluwi M, Al Umran A. Case report: Fibroxanthoma: a complication of a biodegradable screw. Clin Orthop Relat Res. 2010;468:2284-7 pubmed publisher
  51. Satchi K, Loughnan M, McKelvie P, McNab A. Bilateral epibulbar xanthomas--a case report. Cornea. 2010;29:225-7 pubmed publisher
    ..To report bilateral epibulbar xanthomatous lesions in an adult with a normal serum lipid profile and no cutaneous or systemic features of a histiocytic disease...
  52. Kiorpelidou D, Stergiopoulou C, Zioga A, Bassukas I. Linear-agminated juvenile xanthogranulomas. Int J Dermatol. 2008;47:387-9 pubmed publisher
  53. Ilie M, Guevara N, Castillo L, Hofman P. Polypoid intranasal mass caused by Rosai-Dorfman disease: a diagnostic pitfall. J Laryngol Otol. 2010;124:345-8 pubmed publisher
    ..However, extranodal involvement has been documented in less than half of the reported patients, but rarely without associated lymphadenopathy...