foam cells

Summary

Summary: Lipid-laden macrophages originating from monocytes or from smooth muscle cells.

Top Publications

  1. Miller Y, Choi S, Fang L, Harkewicz R. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Trends Cardiovasc Med. 2009;19:227-32 pubmed publisher
    ..A novel hypercholesterolemic zebrafish model of early stages of atherosclerosis was used to demonstrate that the TLR4 deficiency significantly reduces the in vivo rate of macrophage lipid accumulation in vascular lesions...
  2. Li D, Wang D, Wang Y, Ling W, Feng X, Xia M. Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem. 2010;285:33499-509 pubmed publisher
    ..the potential effects of AMPK in modulating cholesterol deposition by using murine macrophage-derived foam cells. Incubation with 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR) markedly attenuated the cholesterol ..
  3. van Tits L, Stienstra R, van Lent P, Netea M, Joosten L, Stalenhoef A. Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2. Atherosclerosis. 2011;214:345-9 pubmed publisher
    Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
  4. Ouimet M, Franklin V, Mak E, Liao X, Tabas I, Marcel Y. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011;13:655-67 pubmed publisher
    The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis...
  5. Tsai J, Su K, Shyue S, Kou Y, Yu Y, Hsiao S, et al. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1. Cardiovasc Res. 2010;88:415-23 pubmed publisher
    Accumulation of foam cells in the intima is a hallmark of early-stage atherosclerotic lesions...
  6. Stellos K, Seizer P, Bigalke B, Daub K, Geisler T, Gawaz M. Platelet aggregates-induced human CD34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro. Semin Thromb Hemost. 2010;36:139-45 pubmed publisher
    ..role of SDF-1 in platelet-induced proliferation and differentiation of human CD34 (+) cells to macrophages and foam cells, as well as in regulation of matrix metalloproteinase (MMP)-9 secretion...
  7. Liang Y, Yang X, Ma L, Cai X, Wang L, Yang C, et al. Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Acta Biochim Biophys Sin (Shanghai). 2013;45:220-8 pubmed publisher
    Homocysteine (Hcy) has been recognized as a prevalent risk factor for cardiovascular events. Cholesterol-loaded foam cells are a central component of atherosclerotic lesions...
  8. Zhao J, Ching L, Huang Y, Chen C, Chiang A, Kou Y, et al. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Mol Nutr Food Res. 2012;56:691-701 pubmed publisher
    ..In this study, we examined the effect of curcumin on lipid accumulation and the underlying molecular mechanisms in macrophages and apolipoprotein E-deficient (apoE?/?) mice...
  9. Seizer P, Schiemann S, Merz T, Daub K, Bigalke B, Stellos K, et al. CD36 and macrophage scavenger receptor a modulate foam cell formation via inhibition of lipid-laden platelet phagocytosis. Semin Thromb Hemost. 2010;36:157-62 pubmed publisher
    ..CD34(+) progenitor cells have the potential to differentiate not only into endothelial cells but also into foam cells upon interaction with platelets...
  10. Zhao J, Shyue S, Lin S, Wei J, Lee T. Excess nitric oxide impairs LXR(?)-ABCA1-dependent cholesterol efflux in macrophage foam cells. J Cell Physiol. 2014;229:117-25 pubmed publisher
    ..little is known about the impact of NO and its underlying molecular mechanism on lipid metabolism of macrophage foam cells. In this study, Oil-red O staining, cholesterol and triglyceride assay, Dil-oxidized LDL (oxLDL) binding assay, ..

Detail Information

Publications62

  1. Miller Y, Choi S, Fang L, Harkewicz R. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Trends Cardiovasc Med. 2009;19:227-32 pubmed publisher
    ..A novel hypercholesterolemic zebrafish model of early stages of atherosclerosis was used to demonstrate that the TLR4 deficiency significantly reduces the in vivo rate of macrophage lipid accumulation in vascular lesions...
  2. Li D, Wang D, Wang Y, Ling W, Feng X, Xia M. Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem. 2010;285:33499-509 pubmed publisher
    ..the potential effects of AMPK in modulating cholesterol deposition by using murine macrophage-derived foam cells. Incubation with 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR) markedly attenuated the cholesterol ..
  3. van Tits L, Stienstra R, van Lent P, Netea M, Joosten L, Stalenhoef A. Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2. Atherosclerosis. 2011;214:345-9 pubmed publisher
    Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
  4. Ouimet M, Franklin V, Mak E, Liao X, Tabas I, Marcel Y. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011;13:655-67 pubmed publisher
    The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis...
  5. Tsai J, Su K, Shyue S, Kou Y, Yu Y, Hsiao S, et al. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1. Cardiovasc Res. 2010;88:415-23 pubmed publisher
    Accumulation of foam cells in the intima is a hallmark of early-stage atherosclerotic lesions...
  6. Stellos K, Seizer P, Bigalke B, Daub K, Geisler T, Gawaz M. Platelet aggregates-induced human CD34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro. Semin Thromb Hemost. 2010;36:139-45 pubmed publisher
    ..role of SDF-1 in platelet-induced proliferation and differentiation of human CD34 (+) cells to macrophages and foam cells, as well as in regulation of matrix metalloproteinase (MMP)-9 secretion...
  7. Liang Y, Yang X, Ma L, Cai X, Wang L, Yang C, et al. Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Acta Biochim Biophys Sin (Shanghai). 2013;45:220-8 pubmed publisher
    Homocysteine (Hcy) has been recognized as a prevalent risk factor for cardiovascular events. Cholesterol-loaded foam cells are a central component of atherosclerotic lesions...
  8. Zhao J, Ching L, Huang Y, Chen C, Chiang A, Kou Y, et al. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Mol Nutr Food Res. 2012;56:691-701 pubmed publisher
    ..In this study, we examined the effect of curcumin on lipid accumulation and the underlying molecular mechanisms in macrophages and apolipoprotein E-deficient (apoE?/?) mice...
  9. Seizer P, Schiemann S, Merz T, Daub K, Bigalke B, Stellos K, et al. CD36 and macrophage scavenger receptor a modulate foam cell formation via inhibition of lipid-laden platelet phagocytosis. Semin Thromb Hemost. 2010;36:157-62 pubmed publisher
    ..CD34(+) progenitor cells have the potential to differentiate not only into endothelial cells but also into foam cells upon interaction with platelets...
  10. Zhao J, Shyue S, Lin S, Wei J, Lee T. Excess nitric oxide impairs LXR(?)-ABCA1-dependent cholesterol efflux in macrophage foam cells. J Cell Physiol. 2014;229:117-25 pubmed publisher
    ..little is known about the impact of NO and its underlying molecular mechanism on lipid metabolism of macrophage foam cells. In this study, Oil-red O staining, cholesterol and triglyceride assay, Dil-oxidized LDL (oxLDL) binding assay, ..
  11. Khera A, Cuchel M, de la Llera Moya M, Rodrigues A, Burke M, Jafri K, et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. 2011;364:127-35 pubmed publisher
    ..We hypothesized that the capacity of HDL to accept cholesterol from macrophages would serve as a predictor of atherosclerotic burden...
  12. Nagashima M, Watanabe T, Shiraishi Y, Morita R, Terasaki M, Arita S, et al. Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice. Atherosclerosis. 2010;212:70-7 pubmed publisher
    ..Thus we investigated the effects of salusin-alpha and -beta on atherosclerotic plaque formation in vivo in apolipoprotein E-deficient (ApoE-/-) mice...
  13. Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, et al. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab. 2009;10:219-28 pubmed publisher
    Cholesterol ester (CE)-laden macrophage foam cells are the hallmark of atherosclerosis, and the hydrolysis of intracellular CE is one of the key steps in foam cell formation...
  14. Stachowska E, Baskiewicz M, Marchlewicz M, Czupryńska K, Kaczmarczyk M, Wiszniewska B, et al. Conjugated linoleic acids regulate triacylglycerol and cholesterol concentrations in macrophages/foam cells by the modulation of CD36 expression. Acta Biochim Pol. 2010;57:379-84 pubmed
    ..Also in human adipocytes, trans-10,cis-12 CLA causes cell delipidation by reduction of PPAR receptor expression. We propose a similar mechanism for human macrophages/foam cells.
  15. Lu Y, Guo J, Di Y, Zong Y, Qu S, Tian J. Proteomic analysis of the triglyceride-rich lipoprotein-laden foam cells. Mol Cells. 2009;28:175-81 pubmed publisher
    ..In vitro studies have suggested that VLDL induces foam cells formation...
  16. Lu K, Ching L, Su K, Yu Y, Kou Y, Hsiao S, et al. Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha. Circulation. 2010;121:1828-37 pubmed publisher
    ..However, the role of erythropoietin and its underlying mechanism in macrophage foam cell formation are poorly understood...
  17. Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim Kaneyama J, et al. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia. 2011;54:2649-59 pubmed publisher
    ..We investigated the possibility that glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can prevent the development of atherosclerosis in Apoe (-/-) mice...
  18. Howell K, Meng X, Fullerton D, Jin C, Reece T, Cleveland J. Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells. J Surg Res. 2011;171:e27-31 pubmed publisher
    Macrophage foam cells are central in the development of atherosclerosis, but the mechanism of foam cell formation is unclear. Toll-like receptor 4 (TLR4) signaling is known to participate in the pathogenesis of atherosclerosis...
  19. Na T, Lee H, Oh H, Huh S, Lee I, Lee M. Positive cross-talk between hypoxia inducible factor-1? and liver X receptor ? induces formation of triglyceride-loaded foam cells. Arterioscler Thromb Vasc Biol. 2011;31:2949-56 pubmed publisher
    ..disease of the arteries that is characterized by subendothelial accumulation of lipid-rich macrophages, called foam cells. We sought to identify the molecular details of cross-talk between liver X receptor ? (LXR?) and hypoxia-..
  20. Yuan Y, Li P, Ye J. Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis. Protein Cell. 2012;3:173-81 pubmed publisher
    ..The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis...
  21. Salehipour M, Javadi E, Reza J, Doosti M, Rezaei S, Paknejad M, et al. Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. Int J Mol Sci. 2010;11:4660-72 pubmed publisher
    Transformation of macrophages to foam cells is determined by the rates of cholesterol uptake and efflux...
  22. Folco E, Sheikine Y, Rocha V, Christen T, Shvartz E, Sukhova G, et al. Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography. J Am Coll Cardiol. 2011;58:603-14 pubmed publisher
  23. Ley K, Miller Y, Hedrick C. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol. 2011;31:1506-16 pubmed publisher
    ..In this review, we discuss these and other processes associated with monocytic cell dynamics in the vascular wall and their role in the initiation and progression of atherosclerosis...
  24. Weibel G, Hayes S, Wilson A, Phillips M, Billheimer J, Rader D, et al. Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages. Arterioscler Thromb Vasc Biol. 2011;31:2865-71 pubmed publisher
    ..so by monitoring the appearance in the feces of labeled cholesterol that originated from peripheral macrophage foam cells. These methods do not account for changes in macrophage cholesterol mass...
  25. Feig J, Rong J, Shamir R, Sanson M, Vengrenyuk Y, Liu J, et al. HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells. Proc Natl Acad Sci U S A. 2011;108:7166-71 pubmed publisher
    ..to an ability to promote the loss of monocyte-derived cells (CD68(+), primarily macrophages and macrophage foam cells) from plaques...
  26. Yu X, Fu Y, Zhang D, Yin K, Tang C. Foam cells in atherosclerosis. Clin Chim Acta. 2013;424:245-52 pubmed publisher
    ..Macrophage foam cells play a critical role in the occurrence and development of atherosclerosis...
  27. Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, et al. Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ Res. 2009;105:500-10 pubmed publisher
    ..proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary atherosclerotic lesions...
  28. Nogi Y, Nagashima M, Terasaki M, Nohtomi K, Watanabe T, Hirano T. Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice. PLoS ONE. 2012;7:e35683 pubmed publisher
    ..GIP receptors (GIPRs) are found to be severely down-regulated in diabetic animals. We examined whether GIP can exert anti-atherogenic effects in diabetes...
  29. Wang Y, Yang X, Cheng B, Mei C, Li Q, Xiao H, et al. Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP-1 derived foam cells exposed to tumor necrosis factor-alpha. Phytother Res. 2010;24:393-8 pubmed publisher
    ..the effects of APS on ABCA1 expression, cholesterol effluent rate and total cholesterol content of THP-1 derived foam cells exposed to TNF-alpha were investigated...
  30. Xie S, Lee Y, Kim E, Chen L, Ni J, Fang L, et al. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci U S A. 2009;106:13353-8 pubmed publisher
  31. Russell D, Cardona P, Kim M, Allain S, Altare F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat Immunol. 2009;10:943-8 pubmed publisher
    ..The foamy macrophage seems to be a key participant in both sustaining persistent bacteria and contributing to the tissue pathology that leads to cavitation and the release of infectious bacilli...
  32. McLaren J, Michael D, Salter R, Ashlin T, Calder C, Miller A, et al. IL-33 reduces macrophage foam cell formation. J Immunol. 2010;185:1222-9 pubmed publisher
    ..E(-/-) mice fed on a high fat diet, IL-33 treatment significantly reduced the accumulation of macrophage-derived foam cells in atherosclerotic plaques...
  33. Hu Y, Wang Q, Ma X, Li X, Liu X, Xiao J, et al. TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells. J Atheroscler Thromb. 2010;17:493-502 pubmed
    High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI)...
  34. Anzinger J, Chang J, Xu Q, Barthwal M, Bohnacker T, Wymann M, et al. Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3K?-dependent fluid-phase pinocytosis of native LDL. J Lipid Res. 2012;53:34-42 pubmed publisher
    ..However, it has not been determined whether murine GM-CSF-differentiated macrophages take up LDL to become foam cells. GM-CSF-differentiated macrophages from LDL receptor-null mice were incubated with LDL, resulting in massive ..
  35. Chai J, Digby J, Ruparelia N, Jefferson A, Handa A, Choudhury R. Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS ONE. 2013;8:e62934 pubmed publisher
    ..Since GPR109A is expressed by human monocytes, we hypothesized that NA may drive cholesterol efflux from foam cells. In THP-1 cells NA suppressed LPS-induced mRNA transcription of MCP-1 by 76.6±12.2% (P<0.01) and TNF? by 56...
  36. Feldmann R, Fischer C, Kodelja V, Behrens S, Haas S, Vingron M, et al. Genome-wide analysis of LXR? activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41:3518-31 pubmed publisher
    ..Lipid-loaded macrophages, termed foam cells, are important during the early development of atherosclerotic plaques...
  37. Luo L, Liu F, Wang X, Dai T, Dai Y, Dong C, et al. An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells. Cell Signal. 2012;24:1889-98 pubmed publisher
    ..lipoprotein (ox-LDL) by macrophages usually leads to the formation of lipid-laden macrophages known as "foam cells," and this process plays an important role in the development of atherosclerosis...
  38. Haka A, Grosheva I, Chiang E, Buxbaum A, Baird B, Pierini L, et al. Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins. Mol Biol Cell. 2009;20:4932-40 pubmed publisher
    ..A detailed understanding of these processes is essential for developing strategies to prevent atherosclerosis...
  39. Terasaki M, Nagashima M, Watanabe T, Nohtomi K, Mori Y, Miyazaki A, et al. Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice. Metabolism. 2012;61:974-7 pubmed publisher
    ..Foam cell formation was suppressed by 40% in the exudate peritoneal macrophages obtained from the PKF-treated mice. The DPP-4 inhibitor prevents the development of atherosclerotic lesions by suppressing macrophage foam cell formation...
  40. Huang Z, Liang C, HAN S, Wu Z. Vitamin E ameliorates ox-LDL-induced foam cells formation through modulating the activities of oxidative stress-induced NF-?B pathway. Mol Cell Biochem. 2012;363:11-9 pubmed publisher
    ..Taken together, these data suggested that vitamin E can prevent ox-LDL-induced foam cell macrophages formation through modulating the activities of oxidative stress-induced NF-?B pathway...
  41. Gessi S, Fogli E, Sacchetto V, Merighi S, Varani K, Preti D, et al. Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells. Arterioscler Thromb Vasc Biol. 2010;30:90-7 pubmed publisher
    ..As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs...
  42. Higashimori M, Tatro J, Moore K, Mendelsohn M, Galper J, Beasley D. Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2011;31:50-7 pubmed publisher
  43. Silverstein R, Li W, Park Y, Rahaman S. Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. Trans Am Clin Climatol Assoc. 2010;121:206-20 pubmed
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development in athero-thrombotic disorders...
  44. McLaren J, Michael D, Ashlin T, Ramji D. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Prog Lipid Res. 2011;50:331-47 pubmed publisher
    ..to plaque development by internalizing native and modified lipoproteins to convert them into cholesterol-rich foam cells. Foam cells not only help to bridge the innate and adaptive immune response to atherosclerosis but also ..
  45. Aronis A, Aharoni Simon M, Madar Z, Tirosh O. Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch Biochem Biophys. 2009;492:74-81 pubmed publisher
    ..2 macrophages and mouse peritoneal macrophages (MPM) foam cells. J774.2 and MPM cells were exposed to triacylglycerol (TG) emulsion (1 mg/ml) for induction of fat accumulation...
  46. Robinet P, Wang Z, Hazen S, Smith J. A simple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells. J Lipid Res. 2010;51:3364-9 pubmed publisher
    ..In conclusion, we describe a sensitive, simple, and high-throughput enzymatic method to quantify cholesterol in complex matrices such as cells...
  47. Rosenblat M, Volkova N, Aviram M. Pomegranate phytosterol (?-sitosterol) and polyphenolic antioxidant (punicalagin) addition to statin, significantly protected against macrophage foam cells formation. Atherosclerosis. 2013;226:110-7 pubmed publisher
  48. Li J, Liu P, Liu J, Yang J, Zhang W, Fan Y, et al. Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug-phospholipids complex technique. Eur J Pharm Biopharm. 2013;83:76-86 pubmed publisher
    ..In conclusion, extrusion/spheronization could be a suitable technique to prepare PC loaded pellets, which could effectively preserve the properties of PC to improve the permeability and bioavailability of highly water-soluble drug...
  49. Lei L, Li H, Yan F, Li Y, Xiao Y. Porphyromonas gingivalis lipopolysaccharide alters atherosclerotic-related gene expression in oxidized low-density-lipoprotein-induced macrophages and foam cells. J Periodontal Res. 2011;46:427-37 pubmed publisher
    ..The aim of this study was to determine whether stimulation with Porphyromonas?gingivalis lipopolysaccharide (LPS) affected the expression of atherosclerosis-related genes, during and after the formation of foam cells.
  50. Yao W, Li K, Liao K. Macropinocytosis contributes to the macrophage foam cell formation in RAW264.7 cells. Acta Biochim Biophys Sin (Shanghai). 2009;41:773-80 pubmed
    ..These results suggested that macropinocytosis might be one of the important mechanisms for lipid uptake in macrophage. And it made significant contribution to the lipid accumulation and foam cell formation...
  51. Zhao Y, Van Berkel T, Van Eck M. Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions. Curr Opin Lipidol. 2010;21:441-53 pubmed publisher
    ..This review focuses on the understanding of the different cholesterol efflux pathways and physiological acceptors involved, and their regulation in atherosclerotic lesions...
  52. Jiang J, Mo Z, Yin K, Zhao G, Lv Y, Ouyang X, et al. Epigallocatechin-3-gallate prevents TNF-?-induced NF-?B activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells. Int J Mol Med. 2012;29:946-56 pubmed publisher
    ..In the study presented here, we found that exposure of macrophage foam cells to TNF-? results in a downregulation of ABCA1 and a decrease in cholesterol efflux to apoA1, which ..
  53. Yuan Y, Zhao L, Chen Y, Moorhead J, Varghese Z, Powis S, et al. Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro. Am J Physiol Renal Physiol. 2011;301:F236-43 pubmed publisher
    ..These data imply that inhibitors of Golgi-processing enzymes might have a potential renoprotective role in prevention of mesangial foam cell formation...
  54. Liu X, Xiao J, Mo Z, Yin K, Jiang J, Cui L, et al. Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells. J Cardiovasc Pharmacol. 2010;56:309-19 pubmed publisher
    ..cAMP)/protein kinase A (PKA) pathway on the regulation of ABCA1 by D4-F in THP-1 macrophage-derived foam cells. Results showed that D4-F stabilized ABCA1 protein and enhanced ABCA1-dependent cholesterol efflux but had no ..
  55. Xue J, Yuan Z, Wu Y, Liu Y, Zhao Y, Zhang W, et al. High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance. Cardiovasc Res. 2010;86:141-50 pubmed publisher
    ..The aim of this study is to investigate the influence of hyperglycaemia on foam cell transformation of vascular smooth muscle cells (VSMCs) and possible mechanisms contributing to these effects...
  56. Becker L, Gharib S, Irwin A, Wijsman E, Vaisar T, Oram J, et al. A macrophage sterol-responsive network linked to atherogenesis. Cell Metab. 2010;11:125-35 pubmed publisher
    ..These observations identify a highly integrated network of proteins whose expression is influenced by environmental, genetic, and pharmacological factors implicated in atherogenesis...
  57. Allahverdian S, Pannu P, Francis G. Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation. Cardiovasc Res. 2012;95:165-72 pubmed publisher
    ..An increased understanding of the contribution of these cell types to lesion development will help to delineate their relative importance in atherogenesis and as potential therapeutic targets...
  58. Michael D, Salter R, Ramji D. TGF-? inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2. Biochim Biophys Acta. 2012;1822:1608-16 pubmed publisher
    ..of key genes implicated in the uptake of modified low density lipoproteins and the efflux of cholesterol from foam cells was Smad-dependent...
  59. Jia Y, Li Z, Zhang H, Li H, Liu Y, Li X. Panax notoginseng saponins decrease cholesterol ester via up-regulating ATP-binding cassette transporter A1 in foam cells. J Ethnopharmacol. 2010;132:297-302 pubmed publisher
    ..This study was designed to examine the relationship of PNS with cholesterol ester in foam cells sourced from macrophages and the effect of PNS on the expression of ATP-binding cassette transporter A1 (ABCA1).
  60. Okabe T, Hoshiga M, Negoro N, Nakakoji T, Arishiro K, Ishihara T, et al. Rabbit plaque models closely resembling lesions in human coronary artery disease. Int J Cardiol. 2011;147:271-7 pubmed publisher
    ..A suitable animal model is required to investigate plaque biology. Here, we examined 6 rabbit models of plaque generated by balloon injury and sequential combinations of normal and high-cholesterol diets...
  61. Lee Rueckert M, Lappalainen J, Leinonen H, Pihlajamaa T, Jauhiainen M, Kovanen P. Acidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells. Arterioscler Thromb Vasc Biol. 2010;30:1766-72 pubmed publisher
    ..In the deep microenvironments of advanced human atherosclerotic lesions, the intimal fluid becomes acidic. We examined the effect of an acidic extracellular pH on cholesterol removal (efflux) from primary human macrophages...
  62. Sabeva N, McPhaul C, Li X, Cory T, Feola D, Graf G. Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells. J Nutr Biochem. 2011;22:777-83 pubmed publisher
    ..ABCG1 abundance, cholesterol efflux and inflammatory cytokine secretion were determined in cultured macrophage foam cells. Among the commonly consumed phytosterols, stigmasterol increased expression of ABCA1 and ABCG1 and increased ..