adipocytes

Summary

Summary: Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.

Top Publications

  1. Rajan M, Fagerholm S, Jonsson C, Kjølhede P, Turkina M, Stralfors P. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. PLoS ONE. 2013;8:e59725 pubmed publisher
    ..This in turn directly affects downstream signaling and is in human adipocytes implicated in the pathogenesis of insulin resistance and type 2 diabetes...
  2. Frontini A, Vitali A, Perugini J, Murano I, Romiti C, Ricquier D, et al. White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim Biophys Acta. 2013;1831:950-9 pubmed publisher
    ..Data in rodents have supported the direct transformation of white into brown adipocytes. Biopsies of pure white omental fat were collected from 12 patients affected by the catecholamine-secreting ..
  3. Moest H, Frei A, Bhattacharya I, Geiger M, Wollscheid B, Wolfrum C. Malfunctioning of adipocytes in obesity is linked to quantitative surfaceome changes. Biochim Biophys Acta. 2013;1831:1208-16 pubmed
    Increased triglyceride accumulation in adipocytes caused by a misbalance between energy intake and energy consumption, results in increased adipocyte size, excess adipose tissue, increased body weight and ultimately, obesity...
  4. Ding C, Wilding J, Bing C. 1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NF?B and MAPK signalling and chemokine release in human adipocytes. PLoS ONE. 2013;8:e61707 pubmed publisher
    ..study investigated the effects of vitamin D3 on macrophage-elicited inflammatory responses in cultured human adipocytes, particularly the signalling pathways involved...
  5. Jespersen N, Larsen T, Peijs L, Daugaard S, Homøe P, Loft A, et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab. 2013;17:798-805 pubmed publisher
    ..the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, ..
  6. Umemoto T, Han C, Mitra P, Averill M, Tang C, Goodspeed L, et al. Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res. 2013;112:1345-54 pubmed publisher
    ..have shown that generation of reactive oxygen species and monocyte chemotactic factors after exposure of adipocytes to saturated fatty acids, such as palmitate, occurs via translocation of NADPH oxidase 4 into lipid rafts (LRs)...
  7. Nieman K, Romero I, Van Houten B, Lengyel E. Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta. 2013;1831:1533-41 pubmed publisher
    ..In this activated state, adipocytes and inflammatory cells secrete adipokines and cytokines which are known to promote tumor development...
  8. Jung U, Jeong K, Kang J, Yi K, Shin J, Seo H, et al. Effects of estrogen receptor ? and ? on the expression of visfatin and retinol-binding protein 4 in 3T3-L1 adipocytes. Int J Mol Med. 2013;32:723-8 pubmed publisher
    ..ER?) and ? (ER?) on the expression of visfatin and retinol-binding protein 4 (RBP4) by treating 3T3-L1 adipocytes with estradiol (E2), estrogen receptor agonists and antagonists...
  9. Zhang C, Xu G, Liu Y, Rao Y, Yu R, Zhang Z, et al. Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. Phytomedicine. 2013;20:221-9 pubmed publisher
    ..anti-diabetic effects of GGQLD in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. The present results suggested GGQLD (4.95, 11.55 and 18...
  10. Stankov M, Panayotova Dimitrova D, Leverkus M, Schmidt R, Behrens G. Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Antimicrob Agents Chemother. 2013;57:543-51 pubmed publisher
    ..the effects of zidovudine (AZT), stavudine (d4T), and lamivudine (3TC) on autophagy in eukaryotic cells and adipocytes (3T3-F442A) by fluorescence microscopy and flow cytometry...

Detail Information

Publications62

  1. Rajan M, Fagerholm S, Jonsson C, Kjølhede P, Turkina M, Stralfors P. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. PLoS ONE. 2013;8:e59725 pubmed publisher
    ..This in turn directly affects downstream signaling and is in human adipocytes implicated in the pathogenesis of insulin resistance and type 2 diabetes...
  2. Frontini A, Vitali A, Perugini J, Murano I, Romiti C, Ricquier D, et al. White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim Biophys Acta. 2013;1831:950-9 pubmed publisher
    ..Data in rodents have supported the direct transformation of white into brown adipocytes. Biopsies of pure white omental fat were collected from 12 patients affected by the catecholamine-secreting ..
  3. Moest H, Frei A, Bhattacharya I, Geiger M, Wollscheid B, Wolfrum C. Malfunctioning of adipocytes in obesity is linked to quantitative surfaceome changes. Biochim Biophys Acta. 2013;1831:1208-16 pubmed
    Increased triglyceride accumulation in adipocytes caused by a misbalance between energy intake and energy consumption, results in increased adipocyte size, excess adipose tissue, increased body weight and ultimately, obesity...
  4. Ding C, Wilding J, Bing C. 1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NF?B and MAPK signalling and chemokine release in human adipocytes. PLoS ONE. 2013;8:e61707 pubmed publisher
    ..study investigated the effects of vitamin D3 on macrophage-elicited inflammatory responses in cultured human adipocytes, particularly the signalling pathways involved...
  5. Jespersen N, Larsen T, Peijs L, Daugaard S, Homøe P, Loft A, et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab. 2013;17:798-805 pubmed publisher
    ..the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, ..
  6. Umemoto T, Han C, Mitra P, Averill M, Tang C, Goodspeed L, et al. Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res. 2013;112:1345-54 pubmed publisher
    ..have shown that generation of reactive oxygen species and monocyte chemotactic factors after exposure of adipocytes to saturated fatty acids, such as palmitate, occurs via translocation of NADPH oxidase 4 into lipid rafts (LRs)...
  7. Nieman K, Romero I, Van Houten B, Lengyel E. Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta. 2013;1831:1533-41 pubmed publisher
    ..In this activated state, adipocytes and inflammatory cells secrete adipokines and cytokines which are known to promote tumor development...
  8. Jung U, Jeong K, Kang J, Yi K, Shin J, Seo H, et al. Effects of estrogen receptor ? and ? on the expression of visfatin and retinol-binding protein 4 in 3T3-L1 adipocytes. Int J Mol Med. 2013;32:723-8 pubmed publisher
    ..ER?) and ? (ER?) on the expression of visfatin and retinol-binding protein 4 (RBP4) by treating 3T3-L1 adipocytes with estradiol (E2), estrogen receptor agonists and antagonists...
  9. Zhang C, Xu G, Liu Y, Rao Y, Yu R, Zhang Z, et al. Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. Phytomedicine. 2013;20:221-9 pubmed publisher
    ..anti-diabetic effects of GGQLD in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. The present results suggested GGQLD (4.95, 11.55 and 18...
  10. Stankov M, Panayotova Dimitrova D, Leverkus M, Schmidt R, Behrens G. Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Antimicrob Agents Chemother. 2013;57:543-51 pubmed publisher
    ..the effects of zidovudine (AZT), stavudine (d4T), and lamivudine (3TC) on autophagy in eukaryotic cells and adipocytes (3T3-F442A) by fluorescence microscopy and flow cytometry...
  11. Huh J, Kim J, Park Y, Hwang I, Lee Y, Sohn J, et al. A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol Cell Biol. 2013;33:328-39 pubmed publisher
    ..Interestingly, CD1d, a molecule involved in lipid antigen presentation to iNKT cells, was highly expressed in adipocytes, and CD1d-expressing adipocytes stimulated iNKT cell activity through physical interaction...
  12. Lee M, Lee S, Kang J, Yang H, Jeong E, Kim H, et al. Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBP? and SREBP1c dependent pathway. Molecules. 2013;18:10484-96 pubmed publisher
    ..be associated with excessive growth of adipocyte mass tissue as a result of increases in the number and size of adipocytes differentiated from preadipocytes...
  13. Kølle S, Fischer Nielsen A, Mathiasen A, Elberg J, Oliveri R, Glovinski P, et al. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet. 2013;382:1113-20 pubmed publisher
    ..Here, we report the results of a triple-blind, placebo-controlled trial to compare the survival of fat grafts enriched with autologous adipose-derived stem cells (ASCs) versus non-enriched fat grafts...
  14. Chatterjee T, Aronow B, Tong W, Manka D, Tang Y, Bogdanov V, et al. Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis. Physiol Genomics. 2013;45:697-709 pubmed publisher
    ..We previously reported that human perivascular (PV) adipocytes exhibit a proinflammatory phenotype and less adipogenic differentiation than do subcutaneous (SQ) adipocytes...
  15. Park K, Kim B, Shawl A, Han M, Lee H, Kim U. Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic ?-cells and adipocytes. J Biol Chem. 2013;288:35548-58 pubmed publisher
    ..we show that NAADP is effectively transported into selected cell types involved in glucose homeostasis, such as adipocytes and pancreatic ?-cells, but not the acinar cells, in a high glucose-dependent manner...
  16. Keuper M, Wernstedt Asterholm I, Scherer P, Westhoff M, Moller P, Debatin K, et al. TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma. Cell Death Dis. 2013;4:e474 pubmed publisher
    ..TRAIL inhibited insulin-stimulated glucose uptake and de novo lipogenesis in human adipocytes. Interestingly, TRAIL did not interfere with the phosphorylation of insulin-stimulated kinases such as Akt or ..
  17. Li P, Carter G, Romero J, Gower K, Watson J, Patel N, et al. Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes. PLoS ONE. 2013;8:e53268 pubmed publisher
    The development of adipocytes from their progenitor cells requires the action of growth factors signaling to transcription factors to induce the expression of adipogenic proteins leading to the accumulation of lipid droplets, induction of ..
  18. de Oliveira E, Sandri S, Knebel F, Contesini C, Campa A, Filippin Monteiro F. Hypoxia increases serum amyloid A3 (SAA3) in differentiated 3T3-L1 adipocytes. Inflammation. 2013;36:1107-10 pubmed publisher
    ..The effect of hypoxia in the expression and production of SAA was examined in murine 3T3-L1 adipocytes. Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (..
  19. Gres S, Gómez Zorita S, Gómez Ruiz A, Carpene C. 5-hydroxytryptamine actions in adipocytes: involvement of monoamine oxidase-dependent oxidation and subsequent PPAR? activation. J Neural Transm (Vienna). 2013;120:919-26 pubmed publisher
    ..Since we already reported that adipocytes exhibit elevated monoamine oxidase (MAO) and primary amine oxidase activities, we verified how adipocytes ..
  20. Esteves C, Kelly V, Begay V, Lillico S, Leutz A, Seckl J, et al. Stable conditional expression and effect of C/ebp?-LIP in adipocytes using the pSLIK system. J Mol Endocrinol. 2013;51:91-8 pubmed publisher
    Murine 3T3-L1 adipocytes are widely used as a cellular model of obesity. However, whereas transfection of 3T3-L1 preadipocytes is straightforward, ectopic gene expression in mature 3T3-L1 adipocytes has proved challenging...
  21. Hsieh Y, Wang S. Lucidone from Lindera erythrocarpa Makino fruits suppresses adipogenesis in 3T3-L1 cells and attenuates obesity and consequent metabolic disorders in high-fat diet C57BL/6 mice. Phytomedicine. 2013;20:394-400 pubmed publisher
    ..tissue from lucidone-treated mice showed a reduction in the average fat-cell size and percentage of large adipocytes. These results provide evidence that dietary intake of lucidone alleviates high fat diet-induced obesity in ..
  22. Jung C, Jang S, Ahn J, Gwon S, Jeon T, Kim T, et al. Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis. J Med Food. 2012;15:959-67 pubmed publisher
    ..Collectively, these results suggest that AOE prevents obesity by suppressing adipogenic and lipogenic genes. AOE has potential for use as an antiobesity therapeutic agent that can function by regulating lipid metabolism...
  23. Kusunoki C, Yang L, Yoshizaki T, Nakagawa F, Ishikado A, Kondo M, et al. Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2013;430:225-30 pubmed publisher
    ..However, the role of ?3-PUFA on adipocytes has not been elucidated...
  24. Lin Z, Tian H, Lam K, Lin S, Hoo R, Konishi M, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 2013;17:779-89 pubmed publisher
    ..Treatments with FGF21 enhanced both expression and secretion of adiponectin in adipocytes, thereby increasing serum levels of adiponectin in mice...
  25. Pope I, Langbein W, Watson P, Borri P. Simultaneous hyperspectral differential-CARS, TPF and SHG microscopy with a single 5 fs Ti:Sa laser. Opt Express. 2013;21:7096-106 pubmed publisher
    ..Examples of CARS hyperspectral images and simultaneous acquisition of D-CARS, TPF and SHG images in both forward and epi-direction are shown on HeLa cells, stem-cell derived human adipocytes and mouse tissues.
  26. Finlin B, Zhu B, Starnes C, McGehee R, Peterson C, Kern P. Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. J Nutr Biochem. 2013;24:1571-9 pubmed publisher
    ..Our objective was to determine how TSP-1 is regulated in adipocytes and polarized macrophages using a coculture system and to determine whether fatty acids, including the ?-3 fatty ..
  27. Soula H, Julienne H, Soulage C, Geloen A. Modelling adipocytes size distribution. J Theor Biol. 2013;332:89-95 pubmed publisher
    b>Adipocytes are cells whose task is to store excess energy as lipid droplets in their cytoplasm. Adipocytes can adapt their size according to the lipid amount to be stored...
  28. Bernhard F, Landgraf K, Kloting N, Berthold A, Buttner P, Friebe D, et al. Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia. 2013;56:311-22 pubmed publisher
    ..We investigated the functional relevance of such genes in human adipocytes.
  29. Pan S, Zheng Y, Zhao R, Yang X. miRNA-374 regulates dexamethasone-induced differentiation of primary cultures of porcine adipocytes. Horm Metab Res. 2013;45:518-25 pubmed publisher
    To investigate the effect of glucocorticoid on adipocytes metabolism and miRNAs that may be involved in adipocyte differentiation, primary porcine preadipocytes were treated with 10-6 M dexamethasone and RU486 (a glucocorticoid receptor ..
  30. He J, Duan H, Xiong Y, Zhang W, Zhou G, Cao Y, et al. Participation of CD34-enriched mouse adipose cells in hair morphogenesis. Mol Med Rep. 2013;7:1111-6 pubmed publisher
    ..As expected, participation in adipogenesis was observed in all groups. Our results suggest that CD34+ cells may represent the ADMSCs which possess stronger multiple differentiation potential during reconstituted skin development...
  31. Grahn T, Zhang Y, Lee M, Sommer A, Mostoslavsky G, Fried S, et al. FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochem Biophys Res Commun. 2013;432:296-301 pubmed publisher
    Human adipocytes express high levels of two distinct lipid droplet proteins, fat specific protein 27 (FSP27; also called CIDEC), a member of the CIDE family, and perilipin1 (PLIN1), a member of the PAT family...
  32. Lee C, Wen J, Hsu Y, Pan T. Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. J Agric Food Chem. 2013;61:1493-500 pubmed publisher
    ..6% and 26.1%) associated with small intestine tissue lipid absorption. Importantly, monascin and ankaflavin are not like monacolin K, which increases creatine phosphokinase (CPK) activity, known as a rhabdomyolysis indicator...
  33. Park H, Chung B, Lee M, Song Y, Lee S, Chu G, et al. Centipede grass exerts anti-adipogenic activity through inhibition of C/EBP?, C/EBP?, and PPAR? expression and the AKT signaling pathway in 3T3-L1 adipocytes. BMC Complement Altern Med. 2012;12:230 pubmed publisher
    ..This study aimed to investigate, for the first time, the antiobesity activity of CG and its potential molecular mechanism in 3T3-L1 cells...
  34. Pan Y, Shu J, Gu H, Zhou D, Liu X, Qiao Q, et al. Erythropoietin improves insulin resistance via the regulation of its receptor-mediated signaling pathways in 3T3L1 adipocytes. Mol Cell Endocrinol. 2013;367:116-23 pubmed publisher
    ..This study aimed to investigate the mechanism by which rHuEPO effects IR in 3T3L1 adipocytes. After treatment with different concentrations of rHuEPO, glucose consumption, and tumor necrosis factor (TNF-?),..
  35. Murholm M, Isidor M, Basse A, Winther S, Sørensen C, Skovgaard Petersen J, et al. Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol. 2013;14:41 pubmed publisher
    ..Thus, regulation of the uncoupling protein 1 (UCP1) gene in human adipocytes is of significant interest...
  36. Kim D, Puri N, Sodhi K, Falck J, Abraham N, Shapiro J, et al. Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J Lipid Res. 2013;54:786-93 pubmed publisher
    ..This study was designed to examine the effects of exogenous 20-HETE on mesenchymal stem cell (MSC)-derived adipocytes. The expression levels of CYP4A11 and CYP4F2 (major 20-HETE synthases in humans) in MSCs decreased during ..
  37. Regazzetti C, Dumas K, Le Marchand Brustel Y, Peraldi P, Tanti J, Giorgetti Peraldi S. Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes. PLoS ONE. 2012;7:e52154 pubmed publisher
    ..In human and murine adipocytes, insulin transiently stimulates REDD1 expression through a MEK dependent pathway...
  38. Rahman M, Syeda P, Khan F, Nishimura K, Jisaka M, Nagaya T, et al. Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. Appl Biochem Biotechnol. 2013;171:128-44 pubmed publisher
    ..types of endogenous prostaglandins (PGs) with opposite effects on adipogenesis at different life stages of adipocytes. However, the specific role of COX isoforms, the rate-limiting enzymes for the pathway, remains elusive in the ..
  39. Liu R, Ding X, Wang Y, Wang M, Peng Y. Glucagon-like peptide-1 upregulates visfatin expression in 3T3-L1 adipocytes. Horm Metab Res. 2013;45:646-51 pubmed publisher
    ..Our study shows that GLP-1 induced secretion of visfatin into the culture medium of 3T3-L1 adipocytes due to increased visfatin mRNA expression...
  40. Coimbra S, Catarino C, Santos Silva A. The role of adipocytes in the modulation of iron metabolism in obesity. Obes Rev. 2013;14:771-9 pubmed publisher
    ..These recent findings suggest that adipose tissue may have an important role in erythropoiesis particularly on obesity that is still poorly clarified. This paper discusses these findings and how they can modulate erythropoiesis. ..
  41. Ayala Sumuano J, Vélez Delvalle C, Beltrán Langarica A, Marsch Moreno M, Hernandez Mosqueira C, Kuri Harcuch W. Glucocorticoid paradoxically recruits adipose progenitors and impairs lipid homeostasis and glucose transport in mature adipocytes. Sci Rep. 2013;3:2573 pubmed publisher
    ..Dexamethasone also had effect on mature adipocytes mature adipocytes causing the downregulation of some lipogenic genes, promoted a lipolysis state, and decreased ..
  42. Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes. 2014;63:514-25 pubmed publisher
    The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation...
  43. Wang W, Lin Q, Lin R, Zhang J, Ren F, Zhang J, et al. PPAR? agonist fenofibrate attenuates TNF-?-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Exp Cell Res. 2013;319:1523-33 pubmed publisher
    ..studies indicated that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, regulates the inflammatory response in adipocytes. However, whether the role of PPAR? in inflammation is mediated by SIRT1 remains unclear...
  44. Nguyen M, Csermely P, Soti C. Hsp90 chaperones PPAR? and regulates differentiation and survival of 3T3-L1 adipocytes. Cell Death Differ. 2013;20:1654-63 pubmed publisher
    ..Geldanamycin at higher concentrations also inhibits the survival of both developing and mature adipocytes, respectively...
  45. Lizunov V, Stenkula K, Troy A, Cushman S, Zimmerberg J. Insulin regulates Glut4 confinement in plasma membrane clusters in adipose cells. PLoS ONE. 2013;8:e57559 pubmed publisher
    ..All together these three effects of insulin shift most of the PM GLUT4 from clustered to dispersed states. GLUT4 confinement in clusters represents a novel kinetic mechanism for insulin regulation of glucose homeostasis...
  46. Zhang J, Zhang Y, Sun T, Guo F, Huang S, Chandalia M, et al. Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2. Sci Rep. 2013;3:1476 pubmed publisher
    ..Altogether, these studies suggest an important role for Egr-1, which, by repressing FOXC2 expression, promotes energy storage in WAT and favored the development of obesity under high energy intake...
  47. Rim H, Moon P, Choi I, Lee E, Kim H, Jeong H. SoSoSo or its active ingredient chrysophanol regulates production of inflammatory cytokines & adipokine in both macrophages & adipocytes. Indian J Med Res. 2013;137:142-50 pubmed
    ..This study was aimed at examining the anti-obesity effect of SoSoSo or its active ingredient chrysophanol on the production of inflammatory cytokines and adipokine in macrophyage cell line RAW264 and 3T3-L1 adipocytes.
  48. Maeda N, Funahashi T, Shimomura I. Cardiovascular-metabolic impact of adiponectin and aquaporin. Endocr J. 2013;60:251-9 pubmed
    ..In this review we summarize adiponectin and aquaporin 7 (AQP7) in the role of metabolic syndrome and cardiovascular diseases...
  49. Wang Y, Tian W, Ma X. Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase. Asian Pac J Cancer Prev. 2012;13:5573-9 pubmed
    ..We also found that EEO could suppress lipid accumulation during the differentiation of 3T3-L1 adipocytes, which was also related to its inhibition of intracellular FAS activity...
  50. Kim M, Kim D, Do M. B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages. Exp Mol Med. 2013;45:e4 pubmed publisher
    3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-? and rosiglitazone...
  51. Poursharifi P, Lapointe M, Pétrin D, Devost D, Gauvreau D, Hebert T, et al. C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology. Cell Signal. 2013;25:910-8 pubmed publisher
    ..study examines the effects of ligands ASP and C5a on interactions between the receptors C5L2 and C5aR in 3T3-L1 adipocytes and J774 macrophages...
  52. Declercq H, De Caluwé T, Krysko O, Bachert C, Cornelissen M. Bone grafts engineered from human adipose-derived stem cells in dynamic 3D-environments. Biomaterials. 2013;34:1004-17 pubmed publisher
    ..This paper showed that high quality bone grafts (2 cm³) can be engineered in a bottom-up approach with cell-laden microcarriers...
  53. Hollenbeck S, Senghaas A, Komatsu I, Zhang Y, Erdmann D, Klitzman B. Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. Wound Repair Regen. 2012;20:872-8 pubmed publisher
    ..These effects are modest and represent the limitations of cellular and growth factor-induced angiogenesis in the acute setting of ischemia...
  54. Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo M. FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment. Cell Death Dis. 2013;4:e861 pubmed publisher
    Finding new molecular pathways and strategies modulating lipolysis in adipocytes is an attractive goal of the current research...
  55. Than A, Zhang X, Leow M, Poh C, Chong S, Chen P. Apelin attenuates oxidative stress in human adipocytes. J Biol Chem. 2014;289:3763-74 pubmed publisher
    ..Apelin is an adipocytokine secreted by adipocytes, and known for its anti-obesity and anti-diabetic properties...
  56. Liu L, Shen W, Ueno M, Patel S, Azhar S, Kraemer F. Age-related modulation of the effects of obesity on gene expression profiles of mouse bone marrow and epididymal adipocytes. PLoS ONE. 2013;8:e72367 pubmed publisher
    ..Alterations in gene expression were analyzed in adipocytes isolated from diet-induced obese (DIO) C57BL/6J male mice at 6 and 14 months of age and from leptin deficient ..
  57. Klein Wieringa I, Andersen S, Kwekkeboom J, Giera M, de Lange Brokaar B, van Osch G, et al. Adipocytes modulate the phenotype of human macrophages through secreted lipids. J Immunol. 2013;191:1356-63 pubmed publisher
    ..profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue...
  58. Fisher C, Grahovac T, Schafer M, Shippert R, Marra K, Rubin J. Comparison of harvest and processing techniques for fat grafting and adipose stem cell isolation. Plast Reconstr Surg. 2013;132:351-61 pubmed publisher
    ..Variability in harvest and processing technique may impact the success of fat grafting. This study compared properties of fat grafts produced by differing methods and assessed volume retention of the grafted tissue in a nude mouse model...
  59. Sato H, Sugai H, Kurosaki H, Ishikawa M, Funaki A, Kimura Y, et al. The effect of sex hormones on peroxisome proliferator-activated receptor gamma expression and activity in mature adipocytes. Biol Pharm Bull. 2013;36:564-73 pubmed
    ..This study evaluated the effects of sex hormones on PPAR? expression and activity in adipocytes. Mouse 3T3-L1 preadipocytes were used after being grown into matured adipocytes...
  60. Ohira H, Fujioka Y, Katagiri C, Mamoto R, Aoyama Ishikawa M, Amako K, et al. Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages. J Atheroscler Thromb. 2013;20:425-42 pubmed
    Paracrine interaction between macrophages and adipocytes in obese visceral fat tissues is thought to be a trigger of chronic inflammation. The immunomodulatory effect of the short chain fatty acid, butyric acid, has been demonstrated...
  61. Suzuki S, Suzuki M, Sembon S, Fuchimoto D, Onishi A. Characterization of actions of octanoate on porcine preadipocytes and adipocytes differentiated in vitro. Biochem Biophys Res Commun. 2013;432:92-8 pubmed publisher
    ..However, information on detailed actions of octanoate and the characteristics of octanoate-induced adipocytes is limited...
  62. Skrzypski M, Kaczmarek P, Le T, Wojciechowicz T, Pruszynska Oszmalek E, Szczepankiewicz D, et al. Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes. FEBS Lett. 2012;586:4157-64 pubmed publisher
    Metabolic activities of orexin A (OXA) in mature adipocytes are mediated via PI3K/PKB and PPAR?. However, the effects of OXA on preadipocytes are largely unknown...