microfibrils

Summary

Summary: Components of the extracellular matrix consisting primarily of fibrillin. They are essential for the integrity of elastic fibers.

Top Publications

  1. Lin G, Tiedemann K, Vollbrandt T, Peters H, Batge B, Brinckmann J, et al. Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils. J Biol Chem. 2002;277:50795-804 pubmed
    Fibrillin-1 and fibrillin-2 constitute the backbone of extracellular filaments, called microfibrils. Fibrillin assembly involves complex multistep mechanisms to result in a periodical head-to-tail alignment in microfibrils...
  2. Sánchez Rodríguez C, Bauer S, Hematy K, Saxe F, Ibáñez A, Vodermaier V, et al. Chitinase-like1/pom-pom1 and its homolog CTL2 are glucan-interacting proteins important for cellulose biosynthesis in Arabidopsis. Plant Cell. 2012;24:589-607 pubmed publisher
    ..Cellulose consists of ?-1,4-linked glucan chains assembled into paracrystalline microfibrils that are synthesized by plasma membrane-located cellulose synthase (CESA) complexes...
  3. Le Goff C, Mahaut C, Wang L, Allali S, Abhyankar A, Jensen S, et al. Mutations in the TGF? binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias. Am J Hum Genet. 2011;89:7-14 pubmed publisher
    ..Although enhanced TGF? signaling caused by FBN1 mutations can trigger either Marfan syndrome or GD and AD, our findings support the fact that TB5 mutations in FBN1 are responsible for short stature phenotypes...
  4. Ono R, Sengle G, Charbonneau N, Carlberg V, Bachinger H, Sasaki T, et al. Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem. 2009;284:16872-81 pubmed publisher
    ..All of these proteins have been immunolocalized to microfibrils. However, in fibrillin-1 (Fbn1) null fibroblast cultures, LTBP-1 and LTBP-4 are not incorporated into ..
  5. Wiberg C, Klatt A, Wagener R, Paulsson M, Bateman J, Heinegard D, et al. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J Biol Chem. 2003;278:37698-704 pubmed
    Native supramolecular assemblies containing collagen VI microfibrils and associated extracellular matrix proteins were isolated from Swarm rat chondrosarcoma tissue...
  6. Yu J, Tirlapur U, Fairbank J, Handford P, Roberts S, Winlove C, et al. Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc. J Anat. 2007;210:460-71 pubmed
    The distribution of microfibrils was studied immunohistochemically in intervertebral discs taken from young normal human surgical cases and from the bovine tail...
  7. Lai Kee Him J, Chanzy H, Muller M, Putaux J, Imai T, Bulone V. In vitro versus in vivo cellulose microfibrils from plant primary wall synthases: structural differences. J Biol Chem. 2002;277:36931-9 pubmed
    ..Both Brij 58 and taurocholate were effective and yielded a substantial percentage of cellulose microfibrils together with (1-->3)-beta-d-glucan (callose)...
  8. Dallas S, Keene D, Bruder S, Saharinen J, Sakai L, Mundy G, et al. Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo. J Bone Miner Res. 2000;15:68-81 pubmed
    ..Immunoelectron microscopy confirmed localization of LTBP1 to 10- to 12-nm microfibrils and suggested an ordered aggregation of LTBP1 into these structures...
  9. Isogai Z, Ono R, Ushiro S, Keene D, Chen Y, Mazzieri R, et al. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003;278:2750-7 pubmed
    ..macromolecules whose primary function is architectural: fibrillins assemble into ultrastructurally distinct microfibrils that are ubiquitous in the connective tissue space...

More Information

Publications81

  1. Charbonneau N, Carlson E, Tufa S, Sengle G, Manalo E, Carlberg V, et al. In vivo studies of mutant fibrillin-1 microfibrils. J Biol Chem. 2010;285:24943-55 pubmed publisher
    ..that is tagged with green fluorescent protein, allowing visualization of mutant fibrillin-1 incorporated into microfibrils. In heterozygosity, these mutant mice demonstrate progressive fragmentation of the aortic elastic lamellae and ..
  2. Goswami L, Dunlop J, Jungnikl K, Eder M, Gierlinger N, Coutand C, et al. Stress generation in the tension wood of poplar is based on the lateral swelling power of the G-layer. Plant J. 2008;56:531-8 pubmed publisher
    ..The results suggest that tensile stresses in poplar are generated in the living plant by a lateral swelling of the G-layer which forces the surrounding secondary cell wall to contract in the axial direction. ..
  3. Kuo C, Isogai Z, Keene D, Hazeki N, Ono R, Sengle G, et al. Effects of fibrillin-1 degradation on microfibril ultrastructure. J Biol Chem. 2007;282:4007-20 pubmed
    Current models of the elastic properties and structural organization of fibrillin-containing microfibrils are based primarily on microscopic analyses of microfibrils liberated from connective tissues after digestion with crude collagenase...
  4. Lamande S, Morgelin M, Adams N, Selan C, Allen J. The C5 domain of the collagen VI alpha3(VI) chain is critical for extracellular microfibril formation and is present in the extracellular matrix of cultured cells. J Biol Chem. 2006;281:16607-14 pubmed
    ..The secreted tetramers associate end-to-end to form beaded microfibrils. Although the basic steps in assembly and the structure of the tetramers and microfibrils are well defined, ..
  5. Baker N, Morgelin M, Peat R, Goemans N, North K, Bateman J, et al. Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy. Hum Mol Genet. 2005;14:279-93 pubmed
    ..Mutation detection in this disorder remains critical for accurate genetic counseling of patients and their families. ..
  6. Charbonneau N, Jordan C, Keene D, Lee Arteaga S, Dietz H, Rifkin D, et al. Microfibril structure masks fibrillin-2 in postnatal tissues. J Biol Chem. 2010;285:20242-51 pubmed publisher
    Fibrillin microfibrils are polymeric structures present in connective tissues...
  7. Emons A, Hofte H, Mulder B. Microtubules and cellulose microfibrils: how intimate is their relationship?. Trends Plant Sci. 2007;12:279-81 pubmed
    ..The ability to label complexes in vivo has provided us with the ideal tool for tackling the intriguing question of the underlying default mechanisms at play. ..
  8. Roudier F, Fernandez A, Fujita M, Himmelspach R, Borner G, Schindelman G, et al. COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation. Plant Cell. 2005;17:1749-63 pubmed
    The orientation of cell expansion is a process at the heart of plant morphogenesis. Cellulose microfibrils are the primary anisotropic material in the cell wall and thus are likely to be the main determinant of the orientation of cell ..
  9. Fujita M, Himmelspach R, Hocart C, Williamson R, Mansfield S, Wasteneys G. Cortical microtubules optimize cell-wall crystallinity to drive unidirectional growth in Arabidopsis. Plant J. 2011;66:915-28 pubmed publisher
    The shape of plants depends on cellulose, a biopolymer that self-assembles into crystalline, inextensible microfibrils (CMFs) upon synthesis at the plasma membrane by multi-enzyme cellulose synthase complexes (CSCs)...
  10. Baldock C, Koster A, Ziese U, Rock M, Sherratt M, Kadler K, et al. The supramolecular organization of fibrillin-rich microfibrils. J Cell Biol. 2001;152:1045-56 pubmed
    We propose a new model for the alignment of fibrillin molecules within fibrillin microfibrils. Automated electron tomography was used to generate three-dimensional microfibril reconstructions to 18...
  11. Desprez T, Juraniec M, Crowell E, Jouy H, Pochylova Z, Parcy F, et al. Organization of cellulose synthase complexes involved in primary cell wall synthesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2007;104:15572-7 pubmed
    ..Participation of the latter three isoforms might fine-tune the CESA complexes for the deposition of microfibrils at distinct cellular growth stages.
  12. Ding S, Himmel M. The maize primary cell wall microfibril: a new model derived from direct visualization. J Agric Food Chem. 2006;54:597-606 pubmed
    ..Depending on the thickness of non-cellulosic deposition, the parallel-microfibrils appear in various morphologies ranging from clearly defined to completely embedded in the wall matrixes forming ..
  13. Sherratt M. Tissue elasticity and the ageing elastic fibre. Age (Dordr). 2009;31:305-25 pubmed publisher
    ..Elastic fibres are composite structures composed of a cross-linked elastin core and an outer layer of fibrillin microfibrils. These two components perform distinct roles; elastin stores energy and drives passive recoil, whilst fibrillin ..
  14. Rock M, Cain S, Freeman L, Morgan A, Mellody K, Marson A, et al. Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link. J Biol Chem. 2004;279:23748-58 pubmed
    We have investigated the molecular basis of elastic fiber formation on fibrillin microfibrils. Binding assays revealed high affinity calcium-independent binding of two overlapping fibrillin-1 fragments (encoded by central exons 18-25 and ..
  15. Faury G. Function-structure relationship of elastic arteries in evolution: from microfibrils to elastin and elastic fibres. Pathol Biol (Paris). 2001;49:310-25 pubmed
    ..In vertebrate development, elastin is incorporated in elastic fibres, on a earlier deposited scaffold of microfibrils. The elastic fibres are then arranged in functional concentric elastic lamellae and, with the smooth muscle ..
  16. Carpita N, Defernez M, Findlay K, Wells B, Shoue D, Catchpole G, et al. Cell wall architecture of the elongating maize coleoptile. Plant Physiol. 2001;127:551-65 pubmed
    The primary walls of grasses are composed of cellulose microfibrils, glucuronoarabinoxylans (GAXs), and mixed-linkage beta-glucans, together with smaller amounts of xyloglucans, glucomannans, pectins, and a network of polyphenolic ..
  17. Sugimoto K, Williamson R, Wasteneys G. Wall architecture in the cellulose-deficient rsw1 mutant of Arabidopsis thaliana: microfibrils but not microtubules lose their transverse alignment before microfibrils become unrecognizable in the mitotic and elongation zones of roots. Protoplasma. 2001;215:172-83 pubmed
    ..The normal transverse alignment of microfibrils is severely impaired in the mutant after 8 h, and chemical inhibition of cellulose synthesis by 2,6-..
  18. Lu Y, Sherratt M, Wang M, Baldock C. Tissue specific differences in fibrillin microfibrils analysed using single particle image analysis. J Struct Biol. 2006;155:285-93 pubmed
    Fibrillin microfibrils endow mammalian connective tissues with elasticity and play a fundamental role in the deposition of elastin. The microfibrils are 57 nm periodic supramolecular protein polymers with a mass of 2.5 MDa per repeat...
  19. Harris D, Corbin K, Wang T, Gutierrez R, Bertolo A, Petti C, et al. Cellulose microfibril crystallinity is reduced by mutating C-terminal transmembrane region residues CESA1A903V and CESA3T942I of cellulose synthase. Proc Natl Acad Sci U S A. 2012;109:4098-103 pubmed publisher
    ..13)C solid-state nuclear magnetic resonance spectroscopy and X-ray diffraction, we show that the cellulose microfibrils displayed reduced width and an additional cellulose C4 peak indicative of a degree of crystallinity that is ..
  20. Robinson P, Arteaga Solis E, Baldock C, Collod Beroud G, Booms P, De Paepe A, et al. The molecular genetics of Marfan syndrome and related disorders. J Med Genet. 2006;43:769-87 pubmed
    ..to provide a comprehensive overview of recent advances in the molecular biology of fibrillin and fibrillin-rich microfibrils. Mutations in FBN1 and other genes found in MFS and related disorders will be discussed, and novel concepts ..
  21. Chen E, Larson J, Ekker S. Functional analysis of zebrafish microfibril-associated glycoprotein-1 (Magp1) in vivo reveals roles for microfibrils in vascular development and function. Blood. 2006;107:4364-74 pubmed
    Mutations in fibrillin-1 (FBN1) result in Marfan syndrome, demonstrating a critical requirement for microfibrils in vessel structure and function...
  22. Jordan C, Charbonneau N, Sakai L. Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling. J Musculoskelet Neuronal Interact. 2006;6:366-7 pubmed
  23. Zhang D, Chippada U, Jordan K. Effect of the structural water on the mechanical properties of collagen-like microfibrils: a molecular dynamics Study. Ann Biomed Eng. 2007;35:1216-30 pubmed
    ..The additional resistance contributed by the structural water is attributed to the additional energy cost in breaking the water-mediated hydrogen bonds (water bridges)...
  24. Wachi H, Sato F, Murata H, Nakazawa J, Starcher B, Seyama Y. Development of a new in vitro model of elastic fiber assembly in human pigmented epithelial cells. Clin Biochem. 2005;38:643-53 pubmed
    ..We developed an in vitro model of elastic fiber assembly that provides a comparison of the efficiency of different tropoelastin molecules to organize into fibers...
  25. Yoneda A, Higaki T, Kutsuna N, Kondo Y, Osada H, Hasezawa S, et al. Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Plant Cell Physiol. 2007;48:1393-403 pubmed
    ..microtubules control the direction of cellulose microfibril deposition, and that the parallel cellulose microfibrils determine anisotropic cell expansion and plant cell morphogenesis...
  26. Tiedemann K, Sasaki T, Gustafsson E, Göhring W, Batge B, Notbohm H, et al. Microfibrils at basement membrane zones interact with perlecan via fibrillin-1. J Biol Chem. 2005;280:11404-12 pubmed
    Mutational defects in fibrillin-rich microfibrils give rise to a number of heritable connective tissue disorders, generally termed microfibrillopathies...
  27. Zabler S, Paris O, Burgert I, Fratzl P. Moisture changes in the plant cell wall force cellulose crystallites to deform. J Struct Biol. 2010;171:133-41 pubmed publisher
    Nano-crystallite deformation of cellulose microfibrils in the secondary cell wall layer of spruce wood tracheids was observed during de- and rehydration experiments below the fibre saturation point...
  28. Davies L, Harris P. Atomic force microscopy of microfibrils in primary cell walls. Planta. 2003;217:283-9 pubmed
    Examination of angiosperm primary cell walls by transmission electron microscopy shows that they contain microfibrils that probably consist of cellulose microfibrils surrounded by associated non-cellulosic polysaccharides...
  29. Bax D, Bernard S, Lomas A, Morgan A, Humphries J, Shuttleworth C, et al. Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. J Biol Chem. 2003;278:34605-16 pubmed
    Fibrillins are the major glycoprotein components of microfibrils that form a template for tropoelastin during elastic fibrillogenesis. We have examined cell adhesion to assembled purified microfibrils, and its molecular basis...
  30. Ramirez F, Rifkin D. Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Curr Opin Cell Biol. 2009;21:616-22 pubmed publisher
    ..Recent studies have revealed that fibrillin assemblies (microfibrils) confer both tissue integrity and regulate signaling events that instruct cell performance and that ..
  31. Gabriel L, Wang L, Bader H, Ho J, Majors A, Hollyfield J, et al. ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest Ophthalmol Vis Sci. 2012;53:461-9 pubmed publisher
    ..The authors sought to characterize recombinant ADAMTSL4 and the ocular distribution of ADAMTSL4 and to investigate whether ADAMTSL4 influences the biogenesis of fibrillin-1 microfibrils, which compose the zonule.
  32. Ramirez F, Dietz H. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events. J Cell Physiol. 2007;213:326-30 pubmed
    Fibrillin-rich microfibrils are specialized extracellular matrix assemblies that endow connective tissues with mechanical stability and elastic properties, and that participate in the regulation of organ formation, growth and homeostasis...
  33. Jensen S, Robertson I, Handford P. Dissecting the fibrillin microfibril: structural insights into organization and function. Structure. 2012;20:215-25 pubmed publisher
    ..The 10 to 12 nm diameter fibrillin microfibrils play vital roles in maintaining the structural integrity of these highly dynamic tissues and in regulating ..
  34. Siqueira G, Bras J, Dufresne A. Cellulose whiskers versus microfibrils: influence of the nature of the nanoparticle and its surface functionalization on the thermal and mechanical properties of nanocomposites. Biomacromolecules. 2009;10:425-32 pubmed publisher
    ..It was also proved that the chemical treatment clearly improves the ultimate properties of the nanocomposites...
  35. Thomas L, Forsyth V, Šturcová A, Kennedy C, May R, Altaner C, et al. Structure of cellulose microfibrils in primary cell walls from collenchyma. Plant Physiol. 2013;161:465-76 pubmed publisher
    In the primary walls of growing plant cells, the glucose polymer cellulose is assembled into long microfibrils a few nanometers in diameter...
  36. Knupp C, Pinali C, Munro P, Gruber H, Sherratt M, Baldock C, et al. Structural correlation between collagen VI microfibrils and collagen VI banded aggregates. J Struct Biol. 2006;154:312-26 pubmed
    ..Collagen VI monomers cross-link into tetramers that come together to form long molecular chains known as microfibrils. Collagen VI tetramers are also the most likely candidates for the formation of banded aggregates with an axial ..
  37. Ryden P, Sugimoto Shirasu K, Smith A, Findlay K, Reiter W, McCann M. Tensile properties of Arabidopsis cell walls depend on both a xyloglucan cross-linked microfibrillar network and rhamnogalacturonan II-borate complexes. Plant Physiol. 2003;132:1033-40 pubmed
    ..We conclude that borate-complexed rhamnogalacturonan II and galactosylated xyloglucan contribute to the tensile strength of cell walls...
  38. Kassner A, Hansen U, Miosge N, Reinhardt D, Aigner T, Bruckner Tuderman L, et al. Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol. 2003;22:131-43 pubmed
    ..does not occur in banded collagen fibrils, but rather, is a component of specialized fibrillin-1-containing microfibrils. In territorial cartilage matrix, however, collagen XVI is not a component of aggregates containing fibrillin-1...
  39. Hanssen E, Hew F, Moore E, Gibson M. MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. J Biol Chem. 2004;279:29185-94 pubmed
    ..of microfibril-associated glycoprotein (MAGP)-2 have been investigated with fibrillins and fibrillin-containing microfibrils. Solid phase binding assays were conducted with recombinant fragments covering fibrillin-1 and most of ..
  40. Wasteneys G. Progress in understanding the role of microtubules in plant cells. Curr Opin Plant Biol. 2004;7:651-60 pubmed
    ..have been thought to constrain the movement of cellulose synthase complexes in order to generate transverse microfibrils that are essential for elongation growth...
  41. Freeman L, Lomas A, Hodson N, Sherratt M, Mellody K, Weiss A, et al. Fibulin-5 interacts with fibrillin-1 molecules and microfibrils. Biochem J. 2005;388:1-5 pubmed
    ..We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin...
  42. Kielty C, Sherratt M, Marson A, Baldock C. Fibrillin microfibrils. Adv Protein Chem. 2005;70:405-36 pubmed
    Fibrillin microfibrils are widely distributed extracellular matrix assemblies that endow elastic and nonelastic connective tissues with long-range elasticity...
  43. Saxena I, Brown R. Cellulose biosynthesis: current views and evolving concepts. Ann Bot. 2005;96:9-21 pubmed
    ..To outline the current state of knowledge and discuss the evolution of various viewpoints put forth to explain the mechanism of cellulose biosynthesis. *..
  44. Marga F, Grandbois M, Cosgrove D, Baskin T. Cell wall extension results in the coordinate separation of parallel microfibrils: evidence from scanning electron microscopy and atomic force microscopy. Plant J. 2005;43:181-90 pubmed
    Enlargement of the cell wall requires separation of cellulose microfibrils, mediated by proteins such as expansin; according to the multi-net growth hypothesis, enlargement passively reorients microfibrils...
  45. Kielty C, Sherratt M, Shuttleworth C. Elastic fibres. J Cell Sci. 2002;115:2817-28 pubmed
    ..extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as blood vessels, lungs and skin with the critical properties of elasticity ..
  46. Fernandes A, Thomas L, Altaner C, Callow P, Forsyth V, Apperley D, et al. Nanostructure of cellulose microfibrils in spruce wood. Proc Natl Acad Sci U S A. 2011;108:E1195-203 pubmed publisher
    The structure of cellulose microfibrils in wood is not known in detail, despite the abundance of cellulose in woody biomass and its importance for biology, energy, and engineering...
  47. Wiedemeier A, Judy March J, Hocart C, Wasteneys G, Williamson R, Baskin T. Mutant alleles of Arabidopsis RADIALLY SWOLLEN 4 and 7 reduce growth anisotropy without altering the transverse orientation of cortical microtubules or cellulose microfibrils. Development. 2002;129:4821-30 pubmed
    ..on cell walls having anisotropic mechanical properties, which are hypothesized to arise from aligned cellulose microfibrils. To test this hypothesis and to identify genes involved in controlling plant shape, we isolated mutants in ..
  48. Qiu D, Wilson I, Gan S, Washusen R, Moran G, Southerton S. Gene expression in Eucalyptus branch wood with marked variation in cellulose microfibril orientation and lacking G-layers. New Phytol. 2008;179:94-103 pubmed publisher
    ..trees form tension wood in the upper sides of branches and leaning stems in which cellulose content is higher, microfibrils are typically aligned closely with the fibre axis and the fibres often have a thick inner gelatinous cell wall ..
  49. Hanssen E, Reinboth B, Gibson M. Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils. J Biol Chem. 2003;278:24334-41 pubmed
    Transforming growth factor-beta induced gene-h3 (betaig-h3) was found to co-purify with collagen VI microfibrils, extracted from developing fetal ligament, after equilibrium density gradient centrifugation under both nondenaturing and ..
  50. Nistala H, Lee Arteaga S, Smaldone S, Siciliano G, Ramirez F. Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production. J Biol Chem. 2010;285:34126-33 pubmed publisher
    Mutations in fibrillin-1 or fibrillin-2, the major structural components of extracellular microfibrils, cause pleiotropic manifestations in Marfan syndrome and congenital contractural arachnodactyly, respectively...
  51. Zykwinska A, Thibault J, Ralet M. Organization of pectic arabinan and galactan side chains in association with cellulose microfibrils in primary cell walls and related models envisaged. J Exp Bot. 2007;58:1795-802 pubmed
    The structure of arabinan and galactan domains in association with cellulose microfibrils was investigated using enzymatic and alkali degradation procedures...
  52. Berson J, Theos A, Harper D, Tenza D, Raposo G, Marks M. Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J Cell Biol. 2003;161:521-33 pubmed
    ..Like the pathologic process of amyloidogenesis, the formation of other tissue-specific organelle structures may be similarly dependent on proteolytic activation of physiological fibrillogenic substrates...
  53. Lee S, Knott V, Jovanovic J, Harlos K, Grimes J, Choulier L, et al. Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization. Structure. 2004;12:717-29 pubmed
    Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10-12 nm microfibrils, is dominated by 43 calcium binding epidermal growth factor-like (cbEGF) and 7 transforming growth factor beta binding protein-like (TB) ..
  54. Isogai Z, Aspberg A, Keene D, Ono R, Reinhardt D, Sakai L. Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks. J Biol Chem. 2002;277:4565-72 pubmed
    Fibrillin-containing microfibrils are polymeric structures that are difficult to extract from connective tissues. Proteolytic digestion of tissues has been utilized to release microfibrils for study...
  55. Arteaga Solis E, Sui Arteaga L, Kim M, Schaffler M, Jepsen K, Pleshko N, et al. Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biol. 2011;30:188-94 pubmed publisher
    ..Here we report that deficiency of fibrillin-1 or fibrillin-2 microfibrils causes distinct changes in bone material and mechanical properties...
  56. Massam Wu T, Chiu M, Choudhury R, Chaudhry S, Baldwin A, McGovern A, et al. Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J Cell Sci. 2010;123:3006-18 pubmed publisher
    ..latent TGFbeta-binding protein 1 (LTBP-1), is directly dependent on the pericellular assembly of fibrillin microfibrils, which interact with fibronectin during higher-order fibrillogenesis...
  57. Arteaga Solis E, Gayraud B, Lee S, Shum L, Sakai L, Ramirez F. Regulation of limb patterning by extracellular microfibrils. J Cell Biol. 2001;154:275-81 pubmed
    ..Together, these results imply functional interaction between Fbn2-rich microfibrils and BMP-7 signaling...
  58. Carta L, Pereira L, Arteaga Solis E, Lee Arteaga S, Lenart B, Starcher B, et al. Fibrillins 1 and 2 perform partially overlapping functions during aortic development. J Biol Chem. 2006;281:8016-23 pubmed
    Fibrillin-rich microfibrils are extracellular assemblies that impart structural properties to the connective tissue...
  59. Yu J, Urban J. The elastic network of articular cartilage: an immunohistochemical study of elastin fibres and microfibrils. J Anat. 2010;216:533-41 pubmed publisher
    ..Elastin fibres and microfibrils were dual-immunostained by labelling with distinct fluorescent dyes...
  60. Sherratt M, Holmes D, Shuttleworth C, Kielty C. Substrate-dependent morphology of supramolecular assemblies: fibrillin and type-VI collagen microfibrils. Biophys J. 2004;86:3211-22 pubmed
    ..morphologies of two biochemically distinct native supramolecular assemblies: fibrillin and type-VI collagen microfibrils. These morphologically heterogeneous microfibrillar systems are found in many vertebrate tissues where they ..
  61. Hubmacher D, El Hallous E, Nelea V, Kaartinen M, Lee E, Reinhardt D. Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly. Proc Natl Acad Sci U S A. 2008;105:6548-53 pubmed publisher
    b>Microfibrils are essential elements in elastic and nonelastic tissues contributing to homeostasis and growth factor regulation. Fibrillins form the core of these multicomponent assemblies...
  62. Spokevicius A, Southerton S, Macmillan C, Qiu D, Gan S, Tibbits J, et al. beta-tubulin affects cellulose microfibril orientation in plant secondary fibre cell walls. Plant J. 2007;51:717-26 pubmed publisher
    Cellulose microfibrils are the major structural component of plant secondary cell walls...
  63. Ramirez F, Sakai L, Rifkin D, Dietz H. Extracellular microfibrils in development and disease. Cell Mol Life Sci. 2007;64:2437-46 pubmed
    Fibrillins are the structural components of extracellular microfibrils that impart physical properties to tissues, alone or together with elastin as elastic fibers...
  64. Dietz H, Loeys B, Carta L, Ramirez F. Recent progress towards a molecular understanding of Marfan syndrome. Am J Med Genet C Semin Med Genet. 2005;139C:4-9 pubmed
    ..pleiotropic manifestations are accounted for by mutations in fibrillin-1, the building block of extracellular microfibrils. During the past 10 years, we have witnessed significant progress in delineating the pathological events ..
  65. Iwamoto S, Kai W, Isogai A, Iwata T. Elastic modulus of single cellulose microfibrils from tunicate measured by atomic force microscopy. Biomacromolecules. 2009;10:2571-6 pubmed publisher
    The elastic modulus of single microfibrils from tunicate ( Halocynthia papillosa ) cellulose was measured by atomic force microscopy (AFM)...
  66. Wang M, Lu Y, Baldock C. Fibrillin microfibrils: a key role for the interbead region in elasticity. J Mol Biol. 2009;388:168-79 pubmed publisher
    Fibrillin microfibrils have essential roles in elastic fiber formation and elastic tissue homeostasis, as well as transforming growth factor-beta sequestration...
  67. Ramirez F, Sakai L, Dietz H, Rifkin D. Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology. Physiol Genomics. 2004;19:151-4 pubmed
    ..These observations pave the way to novel therapeutic approaches aimed at counteracting the deleterious consequences of perturbations of connective tissue homeostasis...
  68. Lloyd C, Chan J. The parallel lives of microtubules and cellulose microfibrils. Curr Opin Plant Biol. 2008;11:641-6 pubmed publisher
    ..The dynamic properties of microtubules turn out to be key in understanding the behaviour of the global array and good progress has been made in deciphering the rules by which the array is self-organized...
  69. Marson A, Rock M, Cain S, Freeman L, Morgan A, Mellody K, et al. Homotypic fibrillin-1 interactions in microfibril assembly. J Biol Chem. 2005;280:5013-21 pubmed
    ..Microfibril-associated glycoprotein-1 inhibited N- to C-terminal interactions but not homotypic N-terminal interactions. These fibrillin-1 interactions are likely to regulate pericellular fibrillin-1 microfibril assembly...
  70. Thumma B, Nolan M, Evans R, Moran G. Polymorphisms in cinnamoyl CoA reductase (CCR) are associated with variation in microfibril angle in Eucalyptus spp. Genetics. 2005;171:1257-65 pubmed
    ..This study demonstrates that LD mapping can be used to identify alleles associated with wood quality traits in natural populations of trees...
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