perilymph

Summary

Summary: The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)

Top Publications

  1. Ohyama K, Salt A, Thalmann R. Volume flow rate of perilymph in the guinea-pig cochlea. Hear Res. 1988;35:119-29 pubmed
    The rate of longitudinal flow of perilymph has been measured using an ionic tracer technique...
  2. Bird P, Murray D, Zhang M, Begg E. Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph. Otol Neurotol. 2011;32:933-6 pubmed publisher
    To measure dexamethasone concentrations in the plasma and perilymph of the human ear after intravenous (IV) and intratympanic (IT) administration and to compare these with previous studies with methylprednisolone.
  3. Hara A, Serizawa F, Tabuchi K, Senarita M, Kusakari J. Hydroxyl radical formation in the perilymph of asphyxic guinea pig. Hear Res. 2000;143:110-4 pubmed
    ..OH upon salicylate, were measured in the perilymph of the guinea pig by the high performance liquid chromatography-electrochemical/UV method...
  4. Bobbin R, Bledsoe S. Asphyxia and depolarization increase adenosine levels in perilymph. Hear Res. 2005;205:110-4 pubmed
    ..Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarization by high potassium concentrations or in response to asphyxia...
  5. Kakigi A, Salt A, Takeda T. Effect of artificial endolymph injection into the cochlear duct on perilymph potassium. ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:16-8 pubmed publisher
    ..To investigate the relationship between endolymphatic hydrops and perilymphatic potassium...
  6. Hanson J, Russell P, Chung A, Kaura C, Kaura S, John E, et al. Effect of round window membrane application of nitric oxide on hearing and nitric oxide concentration in perilymph. Int J Pediatr Otorhinolaryngol. 2003;67:585-90 pubmed
    ..However, the effect of NO in the middle ear effusion on cochlear function and on perilymph concentrations of NO has not been reported...
  7. Hyodo J, Hakuba N, Koga K, Watanabe F, Shudou M, Taniguchi M, et al. Hypothermia reduces glutamate efflux in perilymph following transient cochlear ischemia. Neuroreport. 2001;12:1983-7 pubmed
    ..on ischemic injury of the cochlea in gerbils was studied with particular regard to glutamate efflux in the perilymph. Under normothermic conditions interruption of the blood supply to the cochlea for 15 min caused a remarkable ..
  8. Lysaght A, Kao S, Paulo J, Merchant S, Steen H, Stankovic K. Proteome of human perilymph. J Proteome Res. 2011;10:3845-51 pubmed publisher
    ..report the first use of liquid chromatography-tandem mass-spectrometry (LC-MS/MS) to map the proteome of human perilymph. Using LC-MS/MS, we analyzed four samples, two collected from patients with vestibular schwannoma (VS) and two ..
  9. Lamm C, Walliser U, Schumann K, Lamm K. [Oxygen partial pressure measurements in the perilymph and scala tympani in normo- and hyperbaric conditions. An animal experiment study]. HNO. 1988;36:363-6 pubmed
    ..In all animals the pO2 in the perilymph of the scala tympani fell by 34% of the original value during insertion of the sensor into the scala tympani...

More Information

Publications74

  1. Suzuki M, Kawauchi H, Fujiyoshi T, Mogi G. Round window membrane and perilymph in experimental otitis media with effusion. Ann Otol Rhinol Laryngol. 1989;98:980-7 pubmed
    To investigate the influence of middle ear effusion (MEE) on perilymph (PL), an experimental otitis media with effusion (OME) was manufactured in chinchillas by injecting the tympanic cavity with immune complexes...
  2. Swan E, Peppi M, Chen Z, Green K, Evans J, McKenna M, et al. Proteomics analysis of perilymph and cerebrospinal fluid in mouse. Laryngoscope. 2009;119:953-8 pubmed publisher
    Proteins in perilymph may alter the delivery profile of implantable intracochlear drug delivery systems through biofouling. Knowledge of protein composition will help anticipate interactions with delivered agents.
  3. Bachmann G, Su J, Zumegen C, Wittekindt C, Michel O. [Permeability of the round window membrane for prednisolone-21-hydrogen succinate. Prednisolone content of the perilymph after local administration vs. systemic injection]. HNO. 2001;49:538-42 pubmed
    ..The aim of the study was to determine the concentration in the perilymph of prednisolone-21-hydrogen succinate applied into the round window niche in comparison to the concentration ..
  4. Yamazaki M, Naganawa S, Kawai H, Sone M, Nakashima T. Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection. Neuroradiology. 2012;54:1161-9 pubmed publisher
    ..The aims of this study were to evaluate the difference in gadolinium distribution in cochlear perilymph between the two methods by comparing the enhancement of the basal and apical turns and clarify the ..
  5. Zou J, Ramadan U, Pyykko I. Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane. Otol Neurotol. 2010;31:637-41 pubmed publisher
    ..To investigate the inner ear uptake of the contrast agent gadolinium administered intratympanically through transtympanic injection or using a gelatin sponge placed on the round window...
  6. Pierre P, Engmér C, Wallin I, Laurell G, Ehrsson H. High concentrations of thiosulfate in scala tympani perilymph after systemic administration in the guinea pig. Acta Otolaryngol. 2009;129:132-7 pubmed publisher
    High concentrations of the antioxidant thiosulfate reach scala tympani perilymph after i.v. administration in the guinea pig. Thiosulfate concentrations in perilymph remain elevated longer than in blood...
  7. Higashiyama K, Takeuchi S, Azuma H, Sawada S, Yamakawa K, Kakigi A, et al. Bumetanide-induced enlargement of the intercellular space in the stria vascularis critically depends on Na+ transport. Hear Res. 2003;186:1-9 pubmed
    ..space in the stria vascularis (intrastrial space) is a closed space and isolated from both the endolymph and the perilymph in normal tissue...
  8. Ding D, McFadden S, Browne R, Salvi R. Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells. Hear Res. 2003;185:90-6 pubmed
    ..Concurrent injection of EA significantly increased GM concentration in serum and perilymph at all time points sampled (2.5, 5-8, and 12 h post injection)...
  9. Niedermeyer H, Zahneisen G, Luppa P, Busch R, Arnold W. Cortisol levels in the human perilymph after intravenous administration of prednisolone. Audiol Neurootol. 2003;8:316-21 pubmed
    ..To evaluate the level of cortisol within the perilymph after intravenous administration of 125 and 250 mg of prednisolone, serum and perilymph samples of 29 ..
  10. Salt A, Kellner C, Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear Res. 2003;182:24-33 pubmed
    Our understanding of the perilymph kinetics of drugs depends largely on data obtained by the analysis of perilymph samples...
  11. Sim R, Jardine A, Beckenham E. Long-term outcome of children undergoing surgery for suspected perilymph fistula. J Laryngol Otol. 2009;123:298-302 pubmed publisher
    A number of authors have suggested that surgery for suspected perilymph fistula is effective in preventing deterioration of hearing and in improving hearing in some cases in the short term...
  12. Hirt B, Penkova Z, Eckhard A, Liu W, Rask Andersen H, Muller M, et al. The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier. Neuroscience. 2010;168:957-70 pubmed publisher
    ..Auditory function critically depends on the homeostasis of the cochlear fluids perilymph and endolymph...
  13. Ciorba A, Gasparini P, Chicca M, Pinamonti S, Martini A. Reactive oxygen species in human inner ear perilymph. Acta Otolaryngol. 2010;130:240-6 pubmed publisher
    ..of the production of superoxide, a biologically relevant reactive oxygen species (ROS), in human inner ear perilymph (hIP) in pathological conditions, by the activity of the xanthine dehydrogenase/xanthine oxidase (XA/XO) enzyme ..
  14. Bachmann G, Petereit H, Djenabi U, Michel O. [Measuring beta-trace protein for detection of perilymph fistulas]. HNO. 2002;50:129-33 pubmed
    ..We present two initial cases in which a beta-trace protein nephelometric assay provided immunological proof of perilymph in samples taken from the nasopharynx.
  15. Black F, Lilly D, Nashner L, Peterka R, Pesznecker S. Quantitative diagnostic test for perilymph fistulas. Otolaryngol Head Neck Surg. 1987;96:125-34 pubmed
    Clinically, the definitive diagnosis of perilymph fistulas can only be made by tympanotomy. Results of various fistula tests based upon the vestibulo-ocular reflex have not correlated well with findings during tympanotomy...
  16. Yang J, Wu H, Zhang P, Hou D, Chen J, Zhang S. The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration. Acta Otolaryngol. 2008;128:496-504 pubmed
    ..MTH) and dexamethasone (DEX) could successfully and effectively penetrate the round window membrane (RWM) into perilymph. RWM topical application and otocyst infusion with MTH and DEX result in high perilymph drug concentrations and ..
  17. Goto F, Ogawa K, Kunihiro T, Kurashima K, Kobayashi H, Kanzaki J. Perilymph fistula--45 case analysis. Auris Nasus Larynx. 2001;28:29-33 pubmed
    Though perilymph fistula (PLF) is not a rare disease, preoperative diagnosis still remains to be established...
  18. Wit H, Warmerdam T, Albers F. Measurement of the mechanical compliance of the endolymphatic compartments in the guinea pig. Hear Res. 2000;145:82-90 pubmed
    ..endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes...
  19. Bird P, Begg E, Zhang M, Keast A, Murray D, Balkany T. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol. 2007;28:1124-30 pubmed
    To compare methylprednisolone concentrations in the perilymph of the human ear and in plasma after intratympanic (IT) or intravenous (IV) administration.
  20. Hakuba N, Gyo K, Yanagihara N, Mitani A, Kataoka K. Efflux of glutamate into the perilymph of the cochlea following transient ischemia in the gerbil. Neurosci Lett. 1997;230:69-71 pubmed
    ..technique followed by an enzyme cycling analysis, we measured changes in the glutamate levels in the perilymph of gerbil cochleae before, during and after transient ischemic insult...
  21. Yamazaki M, Naganawa S, Tagaya M, Kawai H, Ikeda M, Sone M, et al. Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection. AJNR Am J Neuroradiol. 2012;33:773-8 pubmed publisher
    ..The purpose of this study was to compare the degree of perilymph enhancement with the 2 methods and the perilymph contrast-effect difference with the IV-method in both sides in ..
  22. Ikezono T, Shindo S, Sekiguchi S, Hanprasertpong C, Li L, Pawankar R, et al. Cochlin-tomoprotein: a novel perilymph-specific protein and a potential marker for the diagnosis of perilymphatic fistula. Audiol Neurootol. 2009;14:338-44 pubmed publisher
    ..To date, there is no clinically relevant biochemical marker for perilymph leakage...
  23. Grimm R, Hemenway W, Lebray P, Black F. The perilymph fistula syndrome defined in mild head trauma. Acta Otolaryngol Suppl. 1989;464:1-40 pubmed
    ..studies were carried out on 102 adults with mild cranio-cervical trauma productive of positional vertigo and perilymph fistula as confirmed by laboratory tests, and by the finding of perilymph fistula at tympanotomy in the ..
  24. Kwacz M, Mrówka M, Wysocki J. Differences in the perilymph fluid stimulation before and after experimental stapedotomy. Acta Bioeng Biomech. 2012;14:67-73 pubmed
    A stapedotomy surgery using a piston stapes prosthesis significantly modifies the perilymph fluid stimulation level and always leads to alteration of conditions in sound transmission through the cochlea...
  25. Ghanem T, Breneman K, Rabbitt R, Brown H. Ionic composition of endolymph and perilymph in the inner ear of the oyster toadfish, Opsanus tau. Biol Bull. 2008;214:83-90 pubmed
    The concentrations of free Na+, K+, Ca(+, and Cl(-)in endolymph and perilymph from the inner ear of the oyster toadfish, Opsanus tau, were measured in vivo using double-barreled ion-selective electrodes...
  26. Wit H, Feijen R, Albers F. Cochlear aqueduct flow resistance is not constant during evoked inner ear pressure change in the guinea pig. Hear Res. 2003;175:190-9 pubmed
    ..The change of flow resistance during inner ear pressure variation can be explained by a permeability change of the cochlear aqueduct, caused by a change of structures filling the aqueduct and its entrance in scala tympani...
  27. Rask Andersen H, Schrott Fischer A, Pfaller K, Glueckert R. Perilymph/modiolar communication routes in the human cochlea. Ear Hear. 2006;27:457-65 pubmed
    To analyze communication routes between perilymph spaces and the modiolus in the human cochlea. Such pathways are of potential importance with regard to local inner ear drug delivery and pharmacokinetics.
  28. Laurell G, Teixeira M, Duan M, Sterkers O, Ferrary E. Intact blood-perilymph barrier in the rat after impulse noise trauma. Acta Otolaryngol. 2008;128:608-12 pubmed publisher
    ..The present findings are contradictory to the theory of an increased permeability in the blood-labyrinth barrier as a result of extensive noise exposure...
  29. Mynatt R, Hale S, Gill R, Plontke S, Salt A. Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex. J Assoc Res Otolaryngol. 2006;7:182-93 pubmed
    ..Measurement of drug levels in ST is technically difficult because of the known contamination of perilymph samples taken from the basal cochlear turn with cerebrospinal fluid (CSF)...
  30. Salt A, Hale S, Plonkte S. Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani. J Neurosci Methods. 2006;153:121-9 pubmed
    ..When auditory function is of primary interest, the drug level in the perilymph of scala tympani (ST) is most relevant, since drug in this scala has ready access to the auditory sensory cells...
  31. Marcon S, Patuzzi R. Changes in cochlear responses in guinea pig with changes in perilymphatic K+. Part I: summating potentials, compound action potentials and DPOAEs. Hear Res. 2008;237:76-89 pubmed publisher
    ..the inner hair cells (IHCs) and the type I afferent dendrites are not, presumably because IHCs are shielded from perilymph by supporting cells, and the membranes of the afferent dendrite membranes exposed directly to our perfusates are ..
  32. Yamazaki M, Naganawa S, Kawai H, Nihashi T, Nakashima T. Signal alteration of the cochlear perilymph on 3 different sequences after intratympanic Gd-DTPA administration at 3 tesla: comparison of 3D-FLAIR, 3D-T1-weighted imaging, and 3D-CISS. Magn Reson Med Sci. 2010;9:65-71 pubmed
  33. Ikeda R, Nakaya K, Oshima H, Oshima T, Kawase T, Kobayashi T. Effect of aspiration of perilymph during stapes surgery on the endocochlear potential of guinea pig. Otolaryngol Head Neck Surg. 2011;145:801-5 pubmed publisher
    ..This study investigated the mechanism of acute phase change in cochlear function caused by aspiration of the opened oval window...
  34. Sugiura S, Yoshikawa T, Nishiyama Y, Morishita Y, Sato E, Hattori T, et al. Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR. J Med Virol. 2003;69:72-5 pubmed
    ..this study, real-time polymerase chain reaction (PCR) was used to measure CMV DNA in clinical samples (including perilymph) collected from five patients with deafness...
  35. Salt A, Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane. Hear Res. 2001;154:88-97 pubmed
    ..TMPA was applied to perilymph by irrigation of the intact round window membrane with 2 mM solution...
  36. Hakuba N, Koga K, Shudou M, Watanabe F, Mitani A, Gyo K. Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbils. J Comp Neurol. 2000;418:217-26 pubmed
    ..Occlusion of the vertebral arteries caused an increase in the concentration of glutamate in the perilymph and elevated the compound action potential (CAP) threshold to 24.6 dB at 5 minutes...
  37. House J, Rizer F. Perilymph fistulas in children: experience of the Otologic Medical Group. Am J Otol. 1989;10:493-5 pubmed
    ..progressive, and fluctuating sensorineural hearing loss, dizziness, and meningitis have been attributed to perilymph fistulas in both adults and children. The literature reports fistulas in all types of conditions...
  38. Hara A, Salt A, Thalmann R. Perilymph composition in scala tympani of the cochlea: influence of cerebrospinal fluid. Hear Res. 1989;42:265-71 pubmed
    A commonly used technique to obtain cochlear perilymph for analysis has been the aspiration of samples through the round window membrane...
  39. Boettcher F, Bancroft B, Salvi R. Concentration of salicylate in serum and perilymph of the chinchilla. Arch Otolaryngol Head Neck Surg. 1990;116:681-4 pubmed
    The concentration of salicylate in serum and perilymph was measured in chinchillas after intraperitoneal administration of sodium salicylate. Serum salicylate concentration peaked 2 to 4 hours after a single injection...
  40. Schweitzer V, Woodson B, Mawhinney T, Rarey K, Bauman M, Raymer S, et al. Free amino acid analysis of guinea pig perilymph: a possible clinical assay for the PLF enigma?. Otolaryngol Head Neck Surg. 1990;103:981-5 pubmed
    ..However, the subjective visual characterization of PLF varies among observing surgeons. Furthermore, perilymph can be "contaminated" with serum, blood, cerebrospinal fluid (CSF), and local anesthesia...
  41. Ruel J, Wang J, Demêmes D, Gobaille S, Puel J, Rebillard G. Dopamine transporter is essential for the maintenance of spontaneous activity of auditory nerve neurones and their responsiveness to sound stimulation. J Neurochem. 2006;97:190-200 pubmed
    ..Altogether, these results show that the dopamine transporter is essential for maintaining the spontaneous activity of auditory nerve neurones and their responsiveness to sound stimulation. ..
  42. Böhmer A. On the pathomechanism of cochlear dysfunction in experimental perilymph fistulas. Laryngoscope. 1991;101:1307-12 pubmed
    The mechanism leading to hearing impairment in perilymph fistulas was investigated in guinea pigs with perforated round window membranes (RWM) by analyzing alterations of inner ear fluid pressure, changes of auditory function following ..
  43. Gjuric M, Wigand M, Hosemann W, Berg M. [Selective resection of the lateral semicircular canal with hearing preservation--an animal experiment study]. HNO. 1991;39:476-81 pubmed
    ..Histological study revealed the utmost importance of the fibrin glue perfusion of the perilymph space of the semicircular canal inducing an interruption of the peri- and endolymph flow...
  44. Campbell Bell C, Birch A, Vignali D, Bulters D, Marchbanks R. Reference intervals for the evoked tympanic membrane displacement measurement: a non-invasive measure of intracranial pressure. Physiol Meas. 2017;: pubmed publisher
    ..Postural changes were used to assess pressure transfer between the cerebral spinal fluid (CSF) and the perilymph.
 
 RESULTS
 The range in which 95% of scores fall is -283 to 722 nl (M=132 nl) left ..
  45. Eckhard A, Gleiser C, Arnold H, Rask Andersen H, Kumagami H, Müller M, et al. Water channel proteins in the inner ear and their link to hearing impairment and deafness. Mol Aspects Med. 2012;33:612-37 pubmed publisher
    ..depend on the strict regulation of the volume of the two major extracellular fluid domains of the inner ear, the perilymph and the endolymph...
  46. Hozawa K, Takasaka T, Kawamoto K, Fukuoka K, Usami S, Hozawa J. Effect of high perilymphatic potassium concentration on the guinea pig vestibular sensory epithelium. Acta Otolaryngol Suppl. 1987;435:21-6 pubmed
    ..Judging by these results, high perilymphatic potassium concentration is assumed to affect the synaptic area of the sensory epithelium, leading to reversible nystagmus. ..
  47. Ferrary E, Tran Ba Huy P, Roinel N, Bernard C, Amiel C. Calcium and the inner ear fluids. Acta Otolaryngol Suppl. 1988;460:13-7 pubmed
    ..The ionized Ca was measured with selective microelectrodes. In perilymph, the total Ca concentration (1.2 mM) was similar to the ultrafiltrable Ca concentration in plasma...
  48. Oghalai J. Chlorpromazine inhibits cochlear function in guinea pigs. Hear Res. 2004;198:59-68 pubmed
    ..This suggests that shifting the electromotility transfer function correspondingly reduces the gain of the cochlear amplifier. ..
  49. Wangemann P, Shen Z, Liu J. K(+)-induced stimulation of K+ secretion involves activation of the IsK channel in vestibular dark cells. Hear Res. 1996;100:201-10 pubmed
    Vestibular dark cells in the inner ear secrete K+ from perilymph containing 4 mM K+ to endolymph containing 145 mM K+...
  50. Smouha E, Inouye M, Sobol L, Slepecky N. Histologic changes after semicircular canal occlusion in guinea pigs. Am J Otol. 1999;20:632-8 pubmed
    ..Ten animals underwent semicircular canal occlusion, suctioning of perilymph, ampullectomy, or wide vestibulotomy...
  51. Hatano A, Rikitake M, Komori M, Irie T, Moriyama H. Traumatic perilymphatic fistula with the luxation of the stapes into the vestibule. Auris Nasus Larynx. 2009;36:474-8 pubmed publisher
    ..The patient has been free from vertigo and has exhibited some recovery of his hearing. We discuss the diagnosis along with other therapeutic problems that have been presented in the literature for traumatic perilymphatic fistula. ..
  52. Tigges G, Stoll W, Schmal F. [Prognostic factors in hearing recovery following sudden unilateral deafness]. HNO. 2003;51:305-9 pubmed
    A perilymph fistula is a possible cause for sudden unilateral sensory deafness. In this retrospective study the data of 73 patients with unilateral sudden deafness were analyzed...
  53. SALT A, Hartsock J, Gill R, Smyth D, Kirk J, Verhoeven K. Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs. PLoS ONE. 2017;12:e0183374 pubmed publisher
    ..For such an approach, perilymph concentrations achieved and the distribution in the ear over time have not previously been documented...
  54. Niedermeyer H, Gantumur T, Neubert W, Arnold W. Measles virus and otosclerosis. Adv Otorhinolaryngol. 2007;65:86-92 pubmed
    ..response of the inner ear immune system against MeV proteins, elevated anti-MeV IgG levels were detected in the perilymph of patients with otosclerosis in comparison with the serum levels...
  55. Zou J, Zhang W, Poe D, Qin J, Fornara A, Zhang Y, et al. MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear. Nanomedicine (Lond). 2010;5:739-54 pubmed publisher
    ..The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear...
  56. Fox E, Balkany T, Arenberg I. The Tullio phenomenon and perilymph fistula. Otolaryngol Head Neck Surg. 1988;98:88-9 pubmed
    Establishing the diagnosis of perilymph fistula remains a dilemma. At this time, identification of an active perilymph fistula can be confirmed only by surgery...
  57. Kamerer D, Sando I, Hirsch B, Takagi A. Perilymph fistula resulting from microfissures. Am J Otol. 1987;8:489-94 pubmed
    ..A fourth source of perilymph fistula has previously been suggested by Okano and Harada...
  58. Counter S, Zou J, Bjelke B, Klason T. 3D MRI of the in vivo vestibulo-cochlea labyrinth during Gd-DTPA-BMA uptake. Neuroreport. 2003;14:1707-12 pubmed
    ..The findings demonstrate that Gd-enhanced 3D MRI of the perilymphatic space may be used to examine the morphology, kinetics and intravenous substance delivery in the in vivo mammalian vestibulo-cochlea labyrinth...
  59. Su J, Bachmann G, Tang A, Zumegen C, Michel O, Wittekindt C. [The different levels of prednisolone in perilymph after local and systemic treatment]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003;17:615-7 pubmed
    The present study was to analysis the pharmacokinetics of prednisolone-21-hydrogensuccinate in the perilymph after local and systemic application.
  60. Ikeda R, Nakaya K, Oshima T, Kawase T, Kobayashi T. Calcium concentration in cochlear endolymph after vestibular labyrinth injury. Neuroreport. 2010;21:651-5 pubmed
    ..Hartley guinea pigs underwent lateral semicircular canal transection with suctioning of the perilymph, ampullectomy, or destruction of the lateral part of the vestibule...
  61. Shulman A, Strashun A. Fluid dynamics vascular theory of brain and inner-ear function in traumatic brain injury: a translational hypothesis for diagnosis and treatment. Int Tinnitus J. 2009;15:119-29 pubmed
    ..of a normal state of homeostasis between the fluid compartments in the brain of cerebrospinal fluid and perilymph-endolymph in the labyrinth of the ear...
  62. Sagowski C, Samuel P, Wenzel S, Leuwer R. [Hearing loss following tympanic membrane injury]. HNO. 2004;52:720-3 pubmed
  63. Crawford A, McGrath N. Hearing loss after lumbar puncture. J Clin Neurosci. 2010;17:149-52 pubmed publisher
    ..He was subsequently found to have stenosis of the distal left transverse sinus, which was treated with stenting...
  64. Arnold W, Ferekidis E, Hamann K. The influence of the footplate-perilymph interface on postoperative bone conduction. Adv Otorhinolaryngol. 2007;65:155-7 pubmed
    ..in cases with preoperative moderate sensorineural hearing loss, we recommend total stapedectomy using a Schuknecht steel wire connective tissue prosthesis, which offers a stapes-perilymph interface similar to the normal stapes.
  65. Chen G, Hou S, Hu P, Jin M, Liu J. [Preliminary study on brain-targeted drug delivery via inner ear]. Yao Xue Xue Bao. 2007;42:1102-6 pubmed
    ..b>Perilymph ( PL) and cerebrospinal fluid (CSF) were collected periodically...