mammalian chromosomes

Summary

Summary: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.

Top Publications

  1. Cocquet J, Ellis P, Yamauchi Y, Mahadevaiah S, Affara N, Ward M, et al. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol. 2009;7:e1000244 pubmed publisher
    ..Our results also suggest that the expansion of sex-linked spermatid-expressed genes in mouse is a consequence of the enhancement of PSCR that accompanies Sly amplification. ..
  2. Ng S, Parvanov E, Petkov P, Paigen K. A quantitative assay for crossover and noncrossover molecular events at individual recombination hotspots in both male and female gametes. Genomics. 2008;92:204-9 pubmed publisher
    ..Using this technique, we analyzed recombination events at the Hlx1 hotspot located on mouse chromosome 1, finding that the results agree well with a prior genetic characterization of 3026 male and 3002 female meioses...
  3. Zhou M, Wang Q, Sun J, Li X, Xu L, Yang H, et al. In silico detection and characteristics of novel microRNA genes in the Equus caballus genome using an integrated ab initio and comparative genomic approach. Genomics. 2009;94:125-31 pubmed publisher
    ..Our study will provide a reference point for further study on miRNAs identification in animals and improve the understanding of genome in horse...
  4. Walker A, Roberts R. Characterization of the bovine type I IFN locus: rearrangements, expansions, and novel subfamilies. BMC Genomics. 2009;10:187 pubmed publisher
  5. Lemaitre C, Tannier E, Gautier C, Sagot M. Precise detection of rearrangement breakpoints in mammalian chromosomes. BMC Bioinformatics. 2008;9:286 pubmed publisher
    ..Contrary to current methods which search for synteny blocks and simply return what remains in the genome as breakpoints, we propose to go further and to investigate the breakpoints themselves in order to refine them...
  6. Brinkmeyer Langford C, Childers C, Fritz K, Gustafson Seabury A, Cothran M, Raudsepp T, et al. A high resolution RH map of the bovine major histocompatibility complex. BMC Genomics. 2009;10:182 pubmed publisher
    ..0 assembly and spanning the IIa-III-I and IIb regions of the bovine MHC were mapped on a 12,000rad bovine radiation hybrid (RH) panel to evaluate the different assemblies of the bovine genome sequence...
  7. Amaral P, Finotelo L, de Oliveira E, Pissinatti A, Nagamachi C, Pieczarka J. Phylogenetic studies of the genus Cebus (Cebidae-Primates) using chromosome painting and G-banding. BMC Evol Biol. 2008;8:169 pubmed publisher
    ..olivaceus, C. albifrons, C. apella robustus and C. apella paraguayanus. Cytogenetic studies suggested that the species of this genus have conservative karyotypes, with diploid numbers ranging from 2n = 52 to 2n = 54...
  8. Wiedmann R, Smith T, Nonneman D. SNP discovery in swine by reduced representation and high throughput pyrosequencing. BMC Genet. 2008;9:81 pubmed publisher
  9. Paigen K, Szatkiewicz J, Sawyer K, Leahy N, Parvanov E, Ng S, et al. The recombinational anatomy of a mouse chromosome. PLoS Genet. 2008;4:e1000119 pubmed publisher
    ..It appears that the regulation of mammalian recombination is a complex, dynamic process involving multiple factors reflecting species, sex, individual variation within species, and the properties of individual hotspots...

More Information

Publications78

  1. Sa Q, Hart E, Hill A, Nadeau J, Hoover Plow J. Quantitative trait locus analysis for hemostasis and thrombosis. Mamm Genome. 2008;19:406-12 pubmed publisher
    ..Thus, we have identified new QTLs and candidate genes not previously known to influence thrombotic risk...
  2. Kochan K, Amaral M, Agarwala R, Schäffer A, Riggs P. Application of dissociation curve analysis to radiation hybrid panel marker scoring: generation of a map of river buffalo (B. bubalis) chromosome 20. BMC Genomics. 2008;9:544 pubmed publisher
    ..To improve sensitivity and efficiency of radiation hybrid panel analysis in comparison to gel-based methods, we adapted fluorescence-based real-time PCR and dissociation curve analysis for use as a novel scoring method...
  3. Pauler F, Sloane M, Huang R, Regha K, Koerner M, Tamir I, et al. H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res. 2009;19:221-33 pubmed publisher
  4. Amaral M, Grant J, Riggs P, Stafuzza N, Filho E, Goldammer T, et al. A first generation whole genome RH map of the river buffalo with comparison to domestic cattle. BMC Genomics. 2008;9:631 pubmed publisher
    ..The RH maps aligned to bovine genome sequence assembly Btau_4.0, providing valuable comparative mapping information for both species...
  5. Grey C, Baudat F, de Massy B. Genome-wide control of the distribution of meiotic recombination. PLoS Biol. 2009;7:e35 pubmed publisher
    ..We thus propose that Dsbc1 encodes for a trans-acting factor involved in the specification of initiation sites of meiotic recombination genome wide in mice...
  6. Vingborg R, Gregersen V, Zhan B, Panitz F, Høj A, Sørensen K, et al. A robust linkage map of the porcine autosomes based on gene-associated SNPs. BMC Genomics. 2009;10:134 pubmed publisher
    ..The SNPs were identified in sequence alignments of 4,600 different amplicons obtained from the 12 boars and containing coding regions of genes derived from expressed sequence tags (ESTs) and genomic shotgun sequences...
  7. Parvanov E, Ng S, Petkov P, Paigen K. Trans-regulation of mouse meiotic recombination hotspots by Rcr1. PLoS Biol. 2009;7:e36 pubmed publisher
  8. Millward C, Burrage L, Shao H, Sinasac D, Kawasoe J, Hill Baskin A, et al. Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17. Mamm Genome. 2009;20:71-82 pubmed publisher
    ..These congenic strains provide mouse models to identify genes and metabolic pathways that are involved in the development of NAFLD and aspects of diet-induced metabolic syndrome...
  9. Arias J, Keehan M, Fisher P, Coppieters W, Spelman R. A high density linkage map of the bovine genome. BMC Genet. 2009;10:18 pubmed publisher
    ..Such maps can be used for quality control of other SNPs and for fine mapping of quantitative trait loci (QTL) via linkage disequilibrium (LD)...
  10. Weikard R, Goldammer T, Eberlein A, Kuehn C. Novel transcripts discovered by mining genomic DNA from defined regions of bovine chromosome 6. BMC Genomics. 2009;10:186 pubmed publisher
  11. Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, et al. Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell. 2009;137:1235-46 pubmed publisher
    ..This model will facilitate forward genetics of developmental brain disorders and serve as an invaluable tool for therapeutic development...
  12. Sudbery I, Stalker J, Simpson J, Keane T, Rust A, Hurles M, et al. Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels. Genome Biol. 2009;10:R112 pubmed publisher
  13. Mömke S, Fink S, Wohlke A, Drogemuller C, Distl O. Linkage of bilateral convergent strabismus with exophthalmus (BCSE) to BTA5 and BTA18 in German Brown cattle. Anim Genet. 2008;39:544-9 pubmed publisher
    ..Thus, it is possible that two genes are involved in the development of BCSE. Alternatively, one of these loci could be the cause for the development of BCSE and the other locus could affect the progression and severity of the defect...
  14. Di Meo G, Perucatti A, Floriot S, Hayes H, Schibler L, Incarnato D, et al. An extended river buffalo (Bubalus bubalis, 2n = 50) cytogenetic map: assignment of 68 autosomal loci by FISH-mapping and R-banding and comparison with human chromosomes. Chromosome Res. 2008;16:827-37 pubmed publisher
  15. Akerfelt M, Henriksson E, Laiho A, Vihervaara A, Rautoma K, Kotaja N, et al. Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2. Proc Natl Acad Sci U S A. 2008;105:11224-9 pubmed publisher
    ..Our findings define a physiological role for HSF2 in the regulation of MSYq resident genes and the quality of sperm...
  16. McStay B, Grummt I. The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol. 2008;24:131-57 pubmed publisher
    ..We also review the critical role of the RNA polymerase I transcription factor UBF in the formation of active nucleolar organizer regions (NORs) and maintenance of the euchromatic state of rRNA genes...
  17. Wade C, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, et al. Genome sequence, comparative analysis, and population genetics of the domestic horse. Science. 2009;326:865-7 pubmed publisher
    ..Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds. ..
  18. Lemay D, Lynn D, Martin W, Neville M, Casey T, Rincon G, et al. The bovine lactation genome: insights into the evolution of mammalian milk. Genome Biol. 2009;10:R43 pubmed publisher
    ..The newly assembled Bos taurus genome sequence enables the linkage of bovine milk and lactation data with other mammalian genomes...
  19. Oh R, Ho R, Mar L, Gertsenstein M, Paderova J, Hsien J, et al. Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7. Mol Cell Biol. 2008;28:1092-103 pubmed
    ..Thus, all the imprinted genes located in the region and required for normal development are silenced by an IC2-dependent mechanism on the paternal allele...
  20. Hart E, Caccamo M, Harrow J, Humphray S, Gilbert J, Trevanion S, et al. Lessons learned from the initial sequencing of the pig genome: comparative analysis of an 8 Mb region of pig chromosome 17. Genome Biol. 2007;8:R168 pubmed
    ..We report our findings comparing the annotation of draft sequence assembled at different depths of coverage...
  21. Sekita Y, Wagatsuma H, Nakamura K, Ono R, Kagami M, Wakisaka N, et al. Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008;40:243-8 pubmed publisher
  22. Mao X, Nie W, Wang J, Su W, Ao L, Feng Q, et al. Karyotype evolution in Rhinolophus bats (Rhinolophidae, Chiroptera) illuminated by cross-species chromosome painting and G-banding comparison. Chromosome Res. 2007;15:835-48 pubmed
  23. Trachtulec Z, Vlcek C, Mihola O, Gregorova S, Fotopulosova V, Forejt J. Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse. Genetics. 2008;178:1777-84 pubmed publisher
    ..The lengths of the haplotype blocks deduced from 36 domesticus chromosomes were in tens of kilobases, suggesting that the wild-derived Mmd strains are suitable for fine interval-specific mapping...
  24. de Roos A, Schrooten C, Mullaart E, Calus M, Veerkamp R. Breeding value estimation for fat percentage using dense markers on Bos taurus autosome 14. J Dairy Sci. 2007;90:4821-9 pubmed
    ..64, which was still much higher than BLUP. It is concluded that, when applied to 1 chromosome and if genetic markers close to the QTL are available, the presented model for GS is as accurate as GEN...
  25. Dorsett Y, Robbiani D, Jankovic M, Reina San Martin B, Eisenreich T, Nussenzweig M. A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med. 2007;204:2225-32 pubmed
    ..Here, we report that AID is required for c-myc to Ig V-J(H) translocations induced by IL-6...
  26. Snelling W, Chiu R, Schein J, Hobbs M, Abbey C, Adelson D, et al. A physical map of the bovine genome. Genome Biol. 2007;8:R165 pubmed
    ..The BAC libraries and clone maps are essential for the hybrid clone-by-clone/whole-genome shotgun sequencing approach taken by the bovine genome sequencing project...
  27. Trifonov V, Stanyon R, Nesterenko A, Fu B, Perelman P, O Brien P, et al. Multidirectional cross-species painting illuminates the history of karyotypic evolution in Perissodactyla. Chromosome Res. 2008;16:89-107 pubmed publisher
    ..Our results allow a more reliable estimate of the mode and tempo of evolutionary chromosomal rearrangements, revealing a striking switch between the slowly evolving ceratomorphs and extremely rapidly evolving equids...
  28. Ianella P, Venancio L, Stafuzza N, Miziara M, Agarwala R, Schaffer A, et al. First radiation hybrid map of the river buffalo X chromosome (BBUX) and comparison with BTAX. Anim Genet. 2008;39:196-200 pubmed publisher
  29. Rukść A, Bell Rogers P, Smith J, Baker M. Analysis of spontaneous gene conversion tracts within and between mammalian chromosomes. J Mol Biol. 2008;377:337-51 pubmed publisher
    ..Overall, gene conversion events are similar, both qualitatively and quantitatively, for homologous recombination within and between mammalian chromosomes.
  30. Sussan T, Yang A, Li F, Ostrowski M, Reeves R. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature. 2008;451:73-5 pubmed publisher
    ..Upregulation of Ets2 and, potentially, other genes involved in this kind of protective effect may provide a prophylactic effect in all individuals, regardless of ploidy...
  31. McMillan D, Miethke P, Alsop A, Rens W, O Brien P, Trifonov V, et al. Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus). Chromosome Res. 2007;15:961-74 pubmed publisher
    ..We have established an agreed nomenclature and identified anchor BAC clones for each chromosome that will ensure unambiguous gene localizations...
  32. Goldammer T, Weikard R, Miziara M, Brunner R, Agarwala R, Schaffer A, et al. A radiation hybrid map of river buffalo (Bubalus bubalis) chromosome 7 and comparative mapping to the cattle and human genomes. Cytogenet Genome Res. 2007;119:235-41 pubmed publisher
    ..The data obtained in our study define the evolutionarily conserved segment on BBU7 and HSA4 to be between 3.5 megabases (Mb) and 115.8 Mb in the HSA4 (genome build 36) DNA sequence...
  33. Feng Z, Tang Z, Li K, Liu B, Yu M, Zhao S. Molecular characterization of the BTG2 and BTG3 genes in fetal muscle development of pigs. Gene. 2007;403:170-7 pubmed
    ..Our study indicated that BTG2 and BTG3, especially BTG3 gene, may be important genes for skeletal muscle growth...
  34. Smith J, Bannister L, Bhattacharjee V, Wang Y, Waldman B, Waldman A. Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2. Mol Cell Biol. 2007;27:7816-27 pubmed
    We designed DNA substrates to study intrachromosomal recombination in mammalian chromosomes. Each substrate contains a thymidine kinase (tk) gene fused to a neomycin resistance (neo) gene...
  35. Benetti R, Gonzalo S, Jaco I, Schotta G, Klatt P, Jenuwein T, et al. Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol. 2007;178:925-36 pubmed
    ..These results demonstrate the importance of chromatin architecture in the maintenance of telomere length homeostasis and reveal a novel role for histone lysine methylation in controlling telomere recombination...
  36. Bois P. A highly polymorphic meiotic recombination mouse hot spot exhibits incomplete repair. Mol Cell Biol. 2007;27:7053-62 pubmed
    ..This suggests that complete repair is not required for completion of mammalian meiosis, a scenario that leaves duplex DNA containing mismatches at crossover sites...
  37. Zimonjic D, Ullmannova Benson V, Factor V, Thorgeirsson S, Popescu N. Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease. Cancer Genet Cytogenet. 2009;191:17-26 pubmed publisher
    ..Overall, the present results document selective, nonrandom genomic changes involving chromosomal regions homologous to those implicated in human HCC. ..
  38. He X, Xu X, Liu B. Molecular characterization, chromosomal localization and association analysis with back-fat thickness of porcine LPIN2 and LPIN3. Mol Biol Rep. 2009;36:1819-24 pubmed publisher
    ..Association analysis showed that different genotypes of LPIN2 were associated with back-fat thickness between the 6th and 7th ribs (P < 0.01). ..
  39. Szalai G, Veres M, Duester G, Lawther R, Lockhart M, Felder M. Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3. Biochem Genet. 2008;46:685-95 pubmed publisher
    ..Although Adh6a and Adh6b have expression patterns different from each other, neither expresses like any other gene in the complex, suggesting different control mechanisms and possibly different functions. ..
  40. Keum S, Marchuk D. A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. Circ Cardiovasc Genet. 2009;2:591-8 pubmed publisher
  41. Rosen G, Pung C, Owens C, Caplow J, Kim H, Mozhui K, et al. Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice. Genes Brain Behav. 2009;8:296-308 pubmed publisher
    ..Using bioinformatic tools and the corresponding expression database, we have identified positional candidates in these quantitative trait locus intervals. ..
  42. Ghazizadeh M. Internal ultrastructure of human chromosomes. J Nippon Med Sch. 2008;75:318-9 pubmed
  43. Drogemuller C, Rossi M, Gentile A, Testoni S, Jörg H, Stranzinger G, et al. Arachnomelia in Brown Swiss cattle maps to chromosome 5. Mamm Genome. 2009;20:53-9 pubmed publisher
  44. Kurzweil V, Getman M, Green E, Lane R. Dynamic evolution of V1R putative pheromone receptors between Mus musculus and Mus spretus. BMC Genomics. 2009;10:74 pubmed publisher
  45. Tummala P, Mali R, Guzman E, Zhang X, Mitton K. Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation. Mol Vis. 2010;16:252-71 pubmed
    ..Single promoter resolution of Pol-II distribution patterns suggest the Rho enhancer region and the Rho proximal promoter region become closely associated with the activated gene's promoter complex. ..
  46. Ma J, Milan D, Rocha D. Chromosomal assignment of the porcine NALP5 gene, a candidate gene for female reproductive traits. Anim Reprod Sci. 2009;112:397-401 pubmed publisher
    ..Here we describe the chromosomal assignment of the porcine NALP5 gene to the long arm of pig chromosome 6 (SSC6q21-22), a region known to harbour several reproduction quantitative trait loci. ..
  47. Camateros P, Marino R, Fortin A, Martin J, Skamene E, Sladek R, et al. Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice. Mamm Genome. 2010;21:28-38 pubmed publisher
    ..Our data identify several likely candidate genes from the 16 regions, including Ddr2, Hc, Fbn1, Flt3, Utrn, Enpp2, and Tsc. ..
  48. Ramakrishna N, Meeker H, Li S, Brown W, Rao R, El Idrissi A. Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain. Neuroscience. 2009;161:451-8 pubmed publisher
    ..Elevated beta-catenin might be responsible for altered endothelial cell function/s leading to the impairment of brachial flow velocity observed in DS. ..
  49. Nagamine Y, Pong Wong R, Visscher P, Haley C. Detection of multiple quantitative trait loci and their pleiotropic effects in outbred pig populations. Genet Sel Evol. 2009;41:44 pubmed publisher
    ..Detection of the second QTL in a model reduced the polygenic heritability and should improve accuracy of estimated heritabilities for both QTLs. ..
  50. Qiu H, Xu X, Fan B, Rothschild M, Martin Y, Liu B. Investigation of LDHA and COPB1 as candidate genes for muscle development in the MYOD1 region of pig chromosome 2. Mol Biol Rep. 2010;37:629-36 pubmed publisher
    ..The substitution of c.3096C>T had a significant effect on average BFT, lumbar BFT, tenth rib BFT, carcass weight and last rib BFT. Interestingly, both SNPs were all associated with average BFT, lumbar BFT and tenth rib BFT. ..
  51. Reinholdt L, Czechanski A, Kamdar S, King B, Sun F, Handel M. Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome. Chromosoma. 2009;118:723-36 pubmed publisher
    ..These results reveal mechanisms by which an extra chromosome, but not trisomic gene dose, impact on meiotic progress and infertility. ..
  52. Corte Real J, Rodo J, Almeida P, Garcia J, Coutinho A, Demengeot J, et al. Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse. Genes Immun. 2009;10:93-9 pubmed publisher
    ..In fact, we also found reduced Irf4 gene expression in B cells of C57BL/6 mice. Thus, we propose Irf4 as a candidate for the IgMSC1 locus, which controls IgM homeostatic levels at the level of B-cell terminal differentiation. ..
  53. Solovei I, Joffe B. Inverted nuclear architecture and its development during differentiation of mouse rod photoreceptor cells: a new model to study nuclear architecture. Genetika. 2010;46:1159-63 pubmed
    ..In the article we discuss the implications of the studies of the inverted nuclei for understanding the role of the spatial organization of the nucleus in nuclear functions...
  54. Fontanesi L, Speroni C, Buttazzoni L, Scotti E, Dall Olio S, Nanni Costa L, et al. The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism. J Anim Sci. 2010;88:2235-45 pubmed publisher
    ..However, for practical applications, because the CTSD gene should not be imprinted (we obtained this information from expression analysis in adult skeletal muscle), the different modes of inheritance of the 2 genes have to be considered...
  55. Oh McGinnis R, Bogutz A, Lee K, Higgins M, Lefebvre L. Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol. 2010;10:50 pubmed publisher
    ..When the IC2KO mutation is paternally inherited, epigenetic silencing is lost in the region and the DelTel7 lethality is rescued in compound heterozygotes, leading to viable DelTel7/IC2KO mice...
  56. Dejager L, Libert C, Montagutelli X. Thirty years of Mus spretus: a promising future. Trends Genet. 2009;25:234-41 pubmed publisher
    ..Here, we examine the use of M. spretus from these perspectives. The impending completion of the M. spretus genome sequence will synergize these advantages...
  57. Seidman M, Chew T, Schenkel A, Muller W. PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2. PLoS ONE. 2009;4:e4316 pubmed publisher
  58. Watanabe T, Suzuki T, Ishikawa A, Yokota Y, Ueda H, Yamada R, et al. Genetic and molecular analysis of wild-derived arrhythmic mice. PLoS ONE. 2009;4:e4301 pubmed publisher
    ..Our strategy using wild-derived variant mice may provide a novel opportunity to evaluate circadian and its related disorders in human that arise from the interaction between multiple variant genes...
  59. Furlani D, Li W, Pittermann E, Klopsch C, Wang L, Knopp A, et al. A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart. Cell Transplant. 2009;18:319-31 pubmed publisher
    ..Our study highlights the need for establishment of biosafety criteria in regulating culture- expanded MSCs to achieve the full clinical therapeutic benefits...
  60. Ohlfest J, Ivics Z, Izsvák Z. Transposable elements as plasmid-based vectors for long-term gene transfer into tumors. Methods Mol Biol. 2009;542:105-16 pubmed publisher
    ..Herein we briefly discuss the different transposons available for gene therapy applications, and provide a detailed protocol for nonviral transposon-based gene delivery to solid experimental tumors in mice...
  61. Munroe R, Prabhu V, Acland G, Johnson K, Harris B, O Brien T, et al. Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. BMC Dev Biol. 2009;9:27 pubmed publisher
    ..These tandemly duplicated genes have functional overlap as indicated by the loss of the entire vestibular system in double mutants. Mutants have not been described for Hmx1, the most divergent of the family...
  62. Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta. 2008;1786:32-40 pubmed publisher
    ..Here, I review these studies and discuss the relevance of merotelic kinetochore orientation in cancer cell biology...
  63. Wu C, Nomura K, Goldammer T, Hadfield T, Dalrymple B, McWilliam S, et al. A high-resolution comparative radiation hybrid map of ovine chromosomal regions that are homologous to human chromosome 6 (HSA6). Anim Genet. 2008;39:459-67 pubmed publisher
    ..3%), dog (85.8%), horse (69.3%) and human (88.7%) genomes. These maps contribute to investigations in mammalian chromosome evolution and the search for economic trait loci in sheep...
  64. Wang L, Li D, Li Z. Changes in the reciprocal position of the first polar body and oocyte chromosome set in golden hamsters. Biosci Rep. 2009;29:315-20 pubmed publisher
    ..Early ovulated oocytes, in vitro-matured oocytes and oocytes treated with colchicine should improve the effectiveness of the cloning procedure in golden hamsters as an animal model for human diseases...
  65. Popovic M, Ahlqvist E, Rockenbauer E, Bockermann R, Holmdahl R. Identification of new loci controlling collagen-induced arthritis in mouse using a partial advanced intercross and congenic strains. Scand J Immunol. 2008;68:405-13 pubmed publisher
    ..Both Tcr loci were within CIA loci making them candidate susceptibility genes. The results demonstrate the importance of breaking up genetic regions in smaller fragments to identify the underlying complex set of loci...
  66. Bennardo N, Cheng A, Huang N, Stark J. Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 2008;4:e1000110 pubmed publisher
    ..However, at later steps of repair, alt-NHEJ is a mechanistically distinct pathway of DSB repair, and thus may play a unique role in mutagenesis during cancer development and therapy...
  67. Glant T, Szanto S, Vegvari A, Szabo Z, Kis Toth K, Mikecz K, et al. Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation. J Immunol. 2008;181:1307-14 pubmed
    ..Both Pgia8 and Pgia9 loci on chr15 appear to control IL-6 production in spleen cultures of arthritic mice, providing an important link to the mechanism of autoimmune inflammation...
  68. Reymann S, Borlak J. Topoisomerase II inhibition involves characteristic chromosomal expression patterns. BMC Genomics. 2008;9:324 pubmed publisher
    ..They did, however, not always show similar expression levels, and many of the regulated genes were, in fact, repressed...
  69. Engel N, Raval A, Thorvaldsen J, Bartolomei S. Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking. Hum Mol Genet. 2008;17:3021-9 pubmed publisher
    ..We suggest that enhancers track along the chromosome until they find a suitable promoter sequence to interact with and that insulator elements block further tracking of enhancers...