fungal chromosomes

Summary

Summary: Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.

Top Publications

  1. Börner G, Barot A, Kleckner N. Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis. Proc Natl Acad Sci U S A. 2008;105:3327-32 pubmed publisher
    ..We further propose that regulatory surveillance of normal and abnormal interchromosomal interactions in mitotic and meiotic cells may involve "structure-dependent interchromosomal interaction" (SDIX) checkpoints...
  2. Joshi R, Pina B, Roca J. Positional dependence of transcriptional inhibition by DNA torsional stress in yeast chromosomes. EMBO J. 2010;29:740-8 pubmed publisher
  3. Tsai I, Burt A, Koufopanou V. Conservation of recombination hotspots in yeast. Proc Natl Acad Sci U S A. 2010;107:7847-52 pubmed publisher
    ..Thus, recombination hotspots are not inevitably short-lived, but rather their persistence through evolutionary time will be determined by the frequency of outcrossing events in the life cycle...
  4. Schacherer J, Ruderfer D, Gresham D, Dolinski K, Botstein D, Kruglyak L. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS ONE. 2007;2:e322 pubmed
    ..These data and new visualization tools are accessible online in a new resource: the Yeast SNPs Browser (YSB; http://gbrowse.princeton.edu/cgi-bin/gbrowse/yeast_strains_snps) that is available to all researchers. ..
  5. Tange Y, Niwa O. Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation. Genetics. 2008;179:785-92 pubmed publisher
    ..Further, the bub3 mutant was defective in sister centromere association during metaphase. Together, these findings suggest that fission yeast Bub3 is required for normal spindle dynamics, but not for SAC. ..
  6. Chen S, Tsubouchi T, Rockmill B, Sandler J, Richards D, Vader G, et al. Global analysis of the meiotic crossover landscape. Dev Cell. 2008;15:401-15 pubmed publisher
    ..Lastly, we uncover a surprising role for the synaptonemal complex component Zip1 in repressing crossing over at the centromere...
  7. Courtheoux T, Gay G, Reyes C, Goldstone S, Gachet Y, Tournier S. Dynein participates in chromosome segregation in fission yeast. Biol Cell. 2007;99:627-37 pubmed
    ..These results show an unexpected role for dynein in the control of chromosome segregation in fission yeast, most probably operating during the process of bi-orientation during early mitosis. ..
  8. Shinohara M, Oh S, Hunter N, Shinohara A. Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis. Nat Genet. 2008;40:299-309 pubmed publisher
    ..In contrast, crossover assurance requires all ZMM proteins and full-length synaptonemal complexes...
  9. Newnham L, Jordan P, Rockmill B, Roeder G, Hoffmann E. The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I. Proc Natl Acad Sci U S A. 2010;107:781-5 pubmed publisher
    ..We propose that Mad3 promotes the segregation of NECs that are not tethered by Zip1 at their centromeres. ..

More Information

Publications90

  1. Padmanabhan S, Thakur J, Siddharthan R, Sanyal K. Rapid evolution of Cse4p-rich centromeric DNA sequences in closely related pathogenic yeasts, Candida albicans and Candida dubliniensis. Proc Natl Acad Sci U S A. 2008;105:19797-802 pubmed publisher
    ..We propose that centromeres of these two Candida species are of an intermediate type between point and regional centromeres. ..
  2. Polakova S, Blume C, Zárate J, Mentel M, Jørck Ramberg D, Stenderup J, et al. Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata. Proc Natl Acad Sci U S A. 2009;106:2688-93 pubmed publisher
    ..We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot. ..
  3. Lydeard J, Lipkin Moore Z, Jain S, Eapen V, Haber J. Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends. PLoS Genet. 2010;6:e1000973 pubmed publisher
    ..The severe constraint on 5' to 3' resection, which also abrogates activation of the Mec1-dependent DNA damage checkpoint, permits an unprecedented level of new telomere addition. ..
  4. Ahmad A, Kabir M, Kravets A, Andaluz E, Larriba G, Rustchenko E. Chromosome instability and unusual features of some widely used strains of Candida albicans. Yeast. 2008;25:433-48 pubmed publisher
    ..Instead of BWP17 or CAI4, we recommend using for general research CAF4-2, which is a relatively stable Ura- derivative, and which has been successfully used for more than a decade in our laboratory. ..
  5. Spiesser T, Klipp E, Barberis M. A model for the spatiotemporal organization of DNA replication in Saccharomyces cerevisiae. Mol Genet Genomics. 2009;282:25-35 pubmed publisher
    ..The simulations provide new insights into the complex system of DNA replication, showing that the system is robust to perturbation, and giving hints about the influence of a possible disordered firing. ..
  6. Jeon J, Park S, Chi M, Choi J, Park J, Rho H, et al. Genome-wide functional analysis of pathogenicity genes in the rice blast fungus. Nat Genet. 2007;39:561-5 pubmed
    ..Our findings demonstrate the effectiveness of our platform and provide new insights on the molecular basis of fungal pathogenesis. Our approach promises comprehensive functional genomics in filamentous fungi and beyond. ..
  7. Shor E, Warren C, Tietjen J, Hou Z, Muller U, Alborelli I, et al. The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. PLoS Genet. 2009;5:e1000755 pubmed publisher
    ..Taken together, these results suggest a surprising connection among ORC, replication origins, and cellular metabolism. ..
  8. Ma W, Resnick M, Gordenin D. Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acids Res. 2008;36:1836-46 pubmed publisher
    ..This approach provided direct physical evidence that Apn1 and Apn2 not only repair cellular base damage but also prevent break accumulation that can result from AP sites being channeled into other BER pathway(s). ..
  9. Marsolier Kergoat M, Yeramian E. GC content and recombination: reassessing the causal effects for the Saccharomyces cerevisiae genome. Genetics. 2009;183:31-8 pubmed publisher
    ..These results pave the way for further analyses aimed at the detailed untangling of drives involved in the evolutionary shaping of the yeast genome. ..
  10. Franco A, Meadows J, Millar J. The Dam1/DASH complex is required for the retrieval of unclustered kinetochores in fission yeast. J Cell Sci. 2007;120:3345-51 pubmed
    ..These data provide the first direct evidence that the Dam1/DASH complex can couple the force generated by microtubule depolymerisation to direct chromosome movement in vivo. ..
  11. Koszul R, Kim K, Prentiss M, Kleckner N, Kameoka S. Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope. Cell. 2008;133:1188-201 pubmed publisher
    ..Mechanical properties of the system and biological roles of mid-prophase movement for meiosis, including recombination, are discussed. ..
  12. Storlazzi A, Tesse S, Ruprich Robert G, Gargano S, Pöggeler S, Kleckner N, et al. Coupling meiotic chromosome axis integrity to recombination. Genes Dev. 2008;22:796-809 pubmed publisher
    ..Finally, Rec8 plays related, but synergistic roles with Spo76/Pds5, indicating auxiliary roles for meiotic and mitotic cohesion-associated components...
  13. Barton A, Pekosz M, Kurvathi R, Kaback D. Meiotic recombination at the ends of chromosomes in Saccharomyces cerevisiae. Genetics. 2008;179:1221-35 pubmed publisher
    ..Thus, the distribution of crossovers in S. cerevisiae appears to resemble that found in several higher eukaryotes where the outermost chromosomal regions show increased crossing over. ..
  14. Mavrich T, Ioshikhes I, Venters B, Jiang C, Tomsho L, Qi J, et al. A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Res. 2008;18:1073-83 pubmed publisher
    ..3' NFRs may be important for transcription termination and anti-sense initiation. We present a high-resolution genome-wide map of TFIIB locations that implicates 3' NFRs in gene looping. ..
  15. Grishchuk E, Spiridonov I, McIntosh J. Mitotic chromosome biorientation in fission yeast is enhanced by dynein and a minus-end-directed, kinesin-like protein. Mol Biol Cell. 2007;18:2216-25 pubmed
  16. Westmoreland J, Ma W, Yan Y, Van Hulle K, Malkova A, Resnick M. RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends. PLoS Genet. 2009;5:e1000656 pubmed publisher
    ..Surprisingly, within 1 hr after irradiation, double-length linear molecules are detected in the WT and rad50, but not in rad52, strains that are likely due to crossovers that are largely resection- and RAD50-independent. ..
  17. Forche A, Alby K, Schaefer D, Johnson A, Berman J, Bennett R. The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains. PLoS Biol. 2008;6:e110 pubmed publisher
    ..albicans. We discuss, in light of the long association of C. albicans with warm-blooded animals, the potential advantages of a parasexual cycle over a conventional sexual cycle. ..
  18. Sutani T, Kawaguchi T, Kanno R, Itoh T, Shirahige K. Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction. Curr Biol. 2009;19:492-7 pubmed publisher
    ..Taken together, the presented data suggest that Wpl1-Pds5 complex is inhibitory for cohesion establishment and that Eco1 establishes cohesion by hindering the function of Wpl1-Pds5 temporally in S phase...
  19. Wu W, Lockhart S, Pujol C, Srikantha T, Soll D. Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence. Mol Microbiol. 2007;64:1587-604 pubmed
    ..These results are consistent with the hypothesis that a competitive advantage of natural a/alpha strains over MTL-homozygous offspring maintains the mating system of C. albicans. ..
  20. Gao J, Davidson M, Wahls W. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response. Nucleic Acids Res. 2008;36:2838-51 pubmed publisher
    ..These findings reveal the functional organization of Atf1 and Pcr1, and illustrate several mechanisms by which bZIP proteins can regulate multiple, seemingly disparate activities...
  21. Farman M. Telomeres in the rice blast fungus Magnaporthe oryzae: the world of the end as we know it. FEMS Microbiol Lett. 2007;273:125-32 pubmed
    ..Targeted sequencing of the M. oryzae telomeres provided an opportunity to test this hypothesis, and has yielded valuable insights into the organization and dynamics of these important chromosome regions...
  22. Selmecki A, Gerami Nejad M, Paulson C, Forche A, Berman J. An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol Microbiol. 2008;68:624-41 pubmed publisher
    ..Thus, the major mechanism by which i(5L) formation causes increased azole resistance is by amplifying two genes: ERG11 and TAC1...
  23. Mondoux M, Zakian V. Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres. Genetics. 2007;177:2541-6 pubmed
    ..These data suggest that the TPE levels of individual telomeres are dependent on some aspect of chromosome context...
  24. Gardner M, Bouck D, Paliulis L, Meehl J, O TOOLE E, Haase J, et al. Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules. Cell. 2008;135:894-906 pubmed publisher
    ..In conclusion, we find that length-dependent control of net kMT assembly by kinesin-5 motors yields a simple and stable self-organizing mechanism for chromosome congression...
  25. D Ambrosio C, Schmidt C, Katou Y, Kelly G, Itoh T, Shirahige K, et al. Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. Genes Dev. 2008;22:2215-27 pubmed publisher
    ..This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis...
  26. Indjeian V, Murray A. Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle. Curr Biol. 2007;17:1837-46 pubmed
    ..After the spindle has been depolymerized and allowed to reform, budding yeast sgo1 mutants fail to biorient their sister chromatids and die as cells divide...
  27. Rustchenko E. Chromosome instability in Candida albicans. FEMS Yeast Res. 2007;7:2-11 pubmed
    ..The unusual mode of gene regulation in Candida albicans implies that genes in this organism are distributed nonrandomly over chromosomes...
  28. Rodriguez Carres M, White G, Tsuchiya D, Taga M, VanEtten H. The supernumerary chromosome of Nectria haematococca that carries pea-pathogenicity-related genes also carries a trait for pea rhizosphere competitiveness. Appl Environ Microbiol. 2008;74:3849-56 pubmed publisher
  29. Fedorova N, Khaldi N, Joardar V, Maiti R, Amedeo P, Anderson M, et al. Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genet. 2008;4:e1000046 pubmed publisher
  30. Degtyareva N, Chen L, Mieczkowski P, Petes T, Doetsch P. Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. Mol Cell Biol. 2008;28:5432-45 pubmed publisher
    ..These results illustrate a novel mechanism for genome destabilization that is likely to be relevant to human carcinogenesis...
  31. Strome E, Wu X, Kimmel M, Plon S. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Genetics. 2008;178:1193-207 pubmed publisher
    ..These findings encourage the incorporation of this orthologous gene list into cancer epidemiology studies and suggest further analysis of heterozygous phenotypes in yeast as models of human disease resulting from haplo-insufficiency...
  32. Kats E, Enserink J, Martinez S, Kolodner R. The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants. Mol Cell Biol. 2009;29:5226-37 pubmed publisher
    ..Our results show that ASF1 probably contributes to the maintenance of genome stability through multiple mechanisms, some of which involve the PRR and HRS pathways...
  33. Sabourin M, Tuzon C, Zakian V. Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol Cell. 2007;27:550-61 pubmed
    ..Tel1p binding was dependent on Xrs2p and required for preferential binding of telomerase to short telomeres. These data suggest that Tel1p targets telomerase to the DNA ends most in need of extension...
  34. Buhler C, Borde V, Lichten M. Mapping meiotic single-strand DNA reveals a new landscape of DNA double-strand breaks in Saccharomyces cerevisiae. PLoS Biol. 2007;5:e324 pubmed
  35. Welz Voegele C, Jinks Robertson S. Sequence divergence impedes crossover more than noncrossover events during mitotic gap repair in yeast. Genetics. 2008;179:1251-62 pubmed publisher
  36. Tinline Purvis H, Savory A, Cullen J, Davé A, Moss J, Bridge W, et al. Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast. EMBO J. 2009;28:3400-12 pubmed publisher
  37. Selmecki A, Dulmage K, Cowen L, Anderson J, Berman J. Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. PLoS Genet. 2009;5:e1000705 pubmed publisher
    ..The early appearance of aneuploidy is consistent with a model in which C. albicans becomes more permissive of chromosome rearrangements and segregation defects in the presence of fluconazole...
  38. Unal E, Heidinger Pauli J, Kim W, Guacci V, Onn I, Gygi S, et al. A molecular determinant for the establishment of sister chromatid cohesion. Science. 2008;321:566-9 pubmed publisher
    ..Smc3 head acetylation and its cell cycle regulation provide important insights into the biology and mechanism of cohesion establishment...
  39. Bernard P, Schmidt C, Vaur S, Dheur S, Drogat J, Genier S, et al. Cell-cycle regulation of cohesin stability along fission yeast chromosomes. EMBO J. 2008;27:111-21 pubmed
    ..Hence, cohesin stabilization might be a pre-requisite for cohesion establishment rather than its consequence...
  40. Lee P, Greenwell P, Dominska M, Gawel M, Hamilton M, Petes T. A fine-structure map of spontaneous mitotic crossovers in the yeast Saccharomyces cerevisiae. PLoS Genet. 2009;5:e1000410 pubmed publisher
    ..In addition, about 40% of the conversion events have patterns of marker segregation that are most simply explained as reflecting the repair of a chromosome that was broken in G1 of the cell cycle...
  41. Dekker J. GC- and AT-rich chromatin domains differ in conformation and histone modification status and are differentially modulated by Rpd3p. Genome Biol. 2007;8:R116 pubmed
    ..Isochore domains differ in gene expression levels, replication timing, levels of meiotic recombination and chromatin structure. The molecular basis for these differences is poorly understood...
  42. Cromie G, Hyppa R, Cam H, Farah J, Grewal S, Smith G. A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeast. PLoS Genet. 2007;3:e141 pubmed
  43. Legrand M, Forche A, Selmecki A, Chan C, Kirkpatrick D, Berman J. Haplotype mapping of a diploid non-meiotic organism using existing and induced aneuploidies. PLoS Genet. 2008;4:e1 pubmed publisher
    ..Therefore, induced aneuploidies can be used to generate HapMaps, which are essential for analyzing genome alterations and mitotic recombination events in this clonal organism...
  44. Ji H, Adkins C, Cartwright B, Friedman K. Yeast Est2p affects telomere length by influencing association of Rap1p with telomeric chromatin. Mol Cell Biol. 2008;28:2380-90 pubmed publisher
    ..Taken together, these results suggest that Est2p can directly or indirectly influence the binding of Rap1p to telomeric DNA, implicating telomerase in roles both upstream and downstream of Rap1p in telomere length homeostasis...
  45. Blitzblau H, Bell G, Rodriguez J, Bell S, Hochwagen A. Mapping of meiotic single-stranded DNA reveals double-stranded-break hotspots near centromeres and telomeres. Curr Biol. 2007;17:2003-12 pubmed
    ..At least two levels of regulation govern crossover distribution: where the initiating DNA double-strand breaks (DSBs) occur and whether those DSBs are repaired as crossovers...
  46. Czajkowsky D, Liu J, Hamlin J, Shao Z. DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI. J Mol Biol. 2008;375:12-9 pubmed
    ..Thus, rather than an absolutely defined temporal order of replication, replication timing appears to be essentially probabilistic within individual cells, exhibiting only temporal tendencies within extended domains...
  47. McCune H, Danielson L, Alvino G, Collingwood D, Delrow J, Fangman W, et al. The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae. Genetics. 2008;180:1833-47 pubmed publisher
  48. Mishra P, Baum M, Carbon J. Centromere size and position in Candida albicans are evolutionarily conserved independent of DNA sequence heterogeneity. Mol Genet Genomics. 2007;278:455-65 pubmed
    ..The chromosomal locations and the sizes of CEN DNAs have remained conserved, in agreement with the idea that CEN function in C. albicans is templated by heritable epigenetic mechanisms...
  49. Valenzuela L, Dhillon N, Dubey R, Gartenberg M, Kamakaka R. Long-range communication between the silencers of HMR. Mol Cell Biol. 2008;28:1924-35 pubmed publisher
    ..We further show that silencing is necessary for these long-range interactions, and we present models for Sir-mediated silencing based upon these results...
  50. Coste A, Selmecki A, Forche A, Diogo D, Bougnoux M, d Enfert C, et al. Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates. Eukaryot Cell. 2007;6:1889-904 pubmed
    ..With the combination of these different modifications, sophisticated genotypes were obtained. The development of azole resistance in C. albicans is therefore a powerful instrument for generating genetic diversity...
  51. Garmaroodi H, Taga M. Duplication of a conditionally dispensable chromosome carrying pea pathogenicity (PEP) gene clusters in Nectria haematococca. Mol Plant Microbe Interact. 2007;20:1495-504 pubmed
    ..In a separate fusion experiment, PDA1 CDC accumulated up to four copies in a haploid genome...
  52. Menkis A, Jacobson D, Gustafsson T, Johannesson H. The mating-type chromosome in the filamentous ascomycete Neurospora tetrasperma represents a model for early evolution of sex chromosomes. PLoS Genet. 2008;4:e1000030 pubmed publisher
    ..tetrasperma involved more than one evolutionary event, covers the majority of the mating-type chromosome and is flanked by distal regions with obligate crossovers...
  53. Dershowitz A, Snyder M, Sbia M, Skurnick J, Ong L, Newlon C. Linear derivatives of Saccharomyces cerevisiae chromosome III can be maintained in the absence of autonomously replicating sequence elements. Mol Cell Biol. 2007;27:4652-63 pubmed
    ..Both the replication initiation protein ORC and telomeres or a linear topology were required for the maintenance of chromosome fragments lacking replicators...
  54. Hodgson B, Calzada A, Labib K. Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase. Mol Biol Cell. 2007;18:3894-902 pubmed
    ..In contrast, Tof1 is critical for DNA replication forks to pause at diverse chromosomal sites where nonnucleosomal proteins bind very tightly to DNA, and this role is not shared with Mrc1...
  55. Folco H, Pidoux A, Urano T, Allshire R. Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres. Science. 2008;319:94-7 pubmed publisher
    ..Once assembled, CENP-A(Cnp1) chromatin is propagated by epigenetic means in the absence of heterochromatin. Thus, another, potentially conserved, role for centromeric RNAi-directed heterochromatin has been identified...
  56. Sun S, Xu J. Genetic analyses of a hybrid cross between serotypes A and D strains of the human pathogenic fungus Cryptococcus neoformans. Genetics. 2007;177:1475-86 pubmed
    ..We discuss the implications of our results in our understanding of the speciation and evolution of the C. neoformans species complex...
  57. Gómez E, Nugent R, Laria S, Forsburg S. Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation. Genetics. 2008;179:757-71 pubmed publisher
    ..mst1 mutant sensitivity to hydroxyurea suggests a defect in recovery following HU arrest. We conclude that Mst1 plays essential roles in maintenance of genome stability and recovery from DNA damage...
  58. Putnam C, Hayes T, Kolodner R. Specific pathways prevent duplication-mediated genome rearrangements. Nature. 2009;460:984-9 pubmed publisher
    ..This explains how extensive genome instability is prevented in eukaryotic cells whose genomes contain numerous divergent repeated sequences...
  59. Bystricky K, van Attikum H, Montiel M, Dion V, Gehlen L, Gasser S. Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex. Mol Cell Biol. 2009;29:835-48 pubmed publisher
  60. Hu G, Liu I, Sham A, Stajich J, Dietrich F, Kronstad J. Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans. Genome Biol. 2008;9:R41 pubmed publisher
  61. Perrin R, Fedorova N, Bok J, Cramer R, Wortman J, Kim H, et al. Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLoS Pathog. 2007;3:e50 pubmed
    ..Our findings suggest that LaeA is a novel target for comprehensive modification of chemical diversity and pathogenicity...
  62. Tsubouchi T, MacQueen A, Roeder G. Initiation of meiotic chromosome synapsis at centromeres in budding yeast. Genes Dev. 2008;22:3217-26 pubmed publisher
    ..Our data provide evidence for two classes of synapsis initiation events that differ in location, timing, genetic requirements, and relationship to meiotic recombination...
  63. Mancera E, Bourgon R, Brozzi A, Huber W, Steinmetz L. High-resolution mapping of meiotic crossovers and non-crossovers in yeast. Nature. 2008;454:479-85 pubmed publisher
    ..In addition, because non-crossover hotspots create holes of reduced linkage within haplotype blocks, our results stress the need to incorporate non-crossovers into genetic linkage analysis...
  64. Joshi N, Barot A, Jamison C, Börner G. Pch2 links chromosome axis remodeling at future crossover sites and crossover distribution during yeast meiosis. PLoS Genet. 2009;5:e1000557 pubmed publisher
    ..Pch2 is proposed to reorganize chromosome axes into a tiling array of long-range crossover control modules, resulting in chiasma formation at minimum levels and with maximum spacing...
  65. Payen C, Fischer G, Marck C, Proux C, Sherman D, Coppee J, et al. Unusual composition of a yeast chromosome arm is associated with its delayed replication. Genome Res. 2009;19:1710-21 pubmed publisher
  66. Conrad M, Lee C, Chao G, Shinohara M, Kosaka H, Shinohara A, et al. Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell. 2008;133:1175-87 pubmed publisher
    ..Together with recombination defects described for ndj1, our observations suggest that RPMs and SCs balance the disruption and stabilization of recombinational interactions, respectively, to regulate crossing over...
  67. Chang F, Theis J, Miller J, Nieduszynski C, Newlon C, Weinreich M. Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site. Mol Cell Biol. 2008;28:5071-81 pubmed publisher
    ..This analysis revealed a highly conserved WTW motif 17 to 19 bp from the ACS that is functionally important and is apparent in the 228 phylogenetically conserved ARS elements among the six sensu stricto Saccharomyces species...
  68. Mitra N, Roeder G. A novel nonnull ZIP1 allele triggers meiotic arrest with synapsed chromosomes in Saccharomyces cerevisiae. Genetics. 2007;176:773-87 pubmed
    ..Previous studies have suggested that the Pch2 protein acts in a checkpoint pathway that monitors chromosome synapsis. We hypothesize that the zip1-4LA mutant assembles aberrant SC that triggers the synapsis checkpoint...
  69. Monje Casas F, Prabhu V, Lee B, Boselli M, Amon A. Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex. Cell. 2007;128:477-90 pubmed
    ..We propose that this function of the monopolin complex helps Aurora B coorient sister chromatids during meiosis I...
  70. Ketel C, Wang H, McClellan M, Bouchonville K, Selmecki A, Lahav T, et al. Neocentromeres form efficiently at multiple possible loci in Candida albicans. PLoS Genet. 2009;5:e1000400 pubmed publisher
    ..The ability to select for neocentromere formation and movement in C. albicans permits mechanistic analysis of the assembly and maintenance of a regional centromere...
  71. Smith C, Lam A, Symington L. Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex. Mol Cell Biol. 2009;29:1432-41 pubmed publisher
    ..Thus, the BIR defect observed for rad51 mutants is due to strand invasion failure, whereas the Pol delta complex mutants are proficient for strand invasion but unable to complete extensive tracts of recombination-initiated DNA synthesis...
  72. Unal E, Heidinger Pauli J, Koshland D. DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science. 2007;317:245-8 pubmed
    ..Finally, the DSB-induced cohesion is not limited to broken chromosomes but occurs also on unbroken chromosomes, suggesting that the DNA damage checkpoint through Eco1 provides genome-wide protection of chromosome integrity...
  73. Nakamura K, Okamoto A, Katou Y, Yadani C, Shitanda T, Kaweeteerawat C, et al. Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe. EMBO J. 2008;27:3036-46 pubmed publisher
    ..Chromatin immunoprecipitation analysis shows that Rad51 localizes at centromere around S phase. These data suggest that Rad51 suppresses rearrangements of centromere repeats that result in isochromosome formation...
  74. Rolef Ben Shahar T, Heeger S, Lehane C, East P, Flynn H, Skehel M, et al. Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science. 2008;321:563-6 pubmed publisher
    ..Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent...
  75. Lee K, Zhang Y, Lee S. Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations. Nature. 2008;454:543-6 pubmed publisher
  76. Dutrow N, Nix D, Holt D, Milash B, Dalley B, Westbroek E, et al. Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping. Nat Genet. 2008;40:977-86 pubmed publisher
    ..Finally, we observed strand-specific transcription islands around tRNAs at heterochromatin boundaries inside centromeres. Here, we discuss these new features in terms of organism fitness and transcriptome evolution...
  77. Driscoll R, Hudson A, Jackson S. Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science. 2007;315:649-52 pubmed
    ..These data establish Rtt109p as a member of a new class of histone acetyltransferases and show that its actions are critical for cell survival in the presence of DNA damage during S phase...
  78. Crampton A, Chang F, Pappas D, Frisch R, Weinreich M. An ARS element inhibits DNA replication through a SIR2-dependent mechanism. Mol Cell. 2008;30:156-66 pubmed publisher
    ..These data suggest that Sir2p and I(S) elements inhibit origin activity by promoting an unfavorable chromatin structure for pre-RC assembly...
  79. Schober H, Kalck V, Vega Palas M, van Houwe G, Sage D, Unser M, et al. Controlled exchange of chromosomal arms reveals principles driving telomere interactions in yeast. Genome Res. 2008;18:261-71 pubmed
    ..These results can be explained by the polarized Rabl arrangement of yeast centromeres and telomeres, which promote to telomere pairing by allowing contact between chromosome arms of equal length in anaphase...
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