centromere

Summary

Summary: The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.

Top Publications

  1. Choi E, Strålfors A, Catania S, Castillo A, Svensson J, Pidoux A, et al. Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast. PLoS Genet. 2012;8:e1002985 pubmed publisher
    ..These findings have important implications for genetic and epigenetic processes involved in centromere specification.
  2. Nie H, Li Q, Kong L. Centromere mapping in the Pacific abalone (Haliotis discus hannai) through half-tetrad analysis in gynogenetic diploid families. Anim Genet. 2012;43:290-7 pubmed publisher
    b>Centromere mapping is an essential prerequisite for our understanding of the composition and structure of genomes...
  3. Dunleavy E, Beier N, Gorgescu W, Tang J, Costes S, Karpen G. The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C. PLoS Biol. 2012;10:e1001460 pubmed publisher
    CENP-A (CID in flies) is the histone H3 variant essential for centromere specification, kinetochore formation, and chromosome segregation during cell division...
  4. Aravamudhan P, Felzer Kim I, Joglekar A. The budding yeast point centromere associates with two Cse4 molecules during mitosis. Curr Biol. 2013;23:770-4 pubmed publisher
    The centromere is defined by the incorporation of the centromere-specific histone H3 variant centromere protein A (CENP-A). Like histone H3, CENP-A can form CENP-A-H4 heterotetramers in vitro...
  5. Lee S, Rozenzhak S, Russell P. ?H2A-binding protein Brc1 affects centromere function in fission yeast. Mol Cell Biol. 2013;33:1410-6 pubmed publisher
    ..Brc1 prevents the collapse of stalled replication forks; however, it is unknown whether this activity influences centromere function...
  6. Durand Dubief M, Will W, Petrini E, Theodorou D, Harris R, Crawford M, et al. SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae. PLoS Genet. 2012;8:e1002974 pubmed publisher
    ..that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans, promotes point centromere function through the formation of correct chromatin architecture at centromeres...
  7. Hayden K. Human centromere genomics: now it's personal. Chromosome Res. 2012;20:621-33 pubmed publisher
    Advances in human genomics have accelerated studies in evolution, disease, and cellular regulation. However, centromere sequences, defining the chromosomal interface with spindle microtubules, remain largely absent from ongoing genomic ..
  8. Da Ines O, Abe K, Goubely C, Gallego M, White C. Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana. PLoS Genet. 2012;8:e1002636 pubmed publisher
    ..This centromere pairing extends well beyond the heterochromatic centromere region and, surprisingly, does not require XRCC3 and ..
  9. Padeganeh A, Ryan J, Boisvert J, Ladouceur A, Dorn J, Maddox P. Octameric CENP-A nucleosomes are present at human centromeres throughout the cell cycle. Curr Biol. 2013;23:764-9 pubmed publisher
    The presence of a single centromere on each chromosome that signals formation of a mitotic kinetochore is central to accurate chromosome segregation...

More Information

Publications90

  1. Bodor D, Valente L, Mata J, Black B, Jansen L. Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes. Mol Biol Cell. 2013;24:923-32 pubmed publisher
    Centromeres are the site of kinetochore formation during mitosis. Centromere protein A (CENP-A), the centromere-specific histone H3 variant, is essential for the epigenetic maintenance of centromere position...
  2. Koga A, Hirai Y, Hara T, Hirai H. Repetitive sequences originating from the centromere constitute large-scale heterochromatin in the telomere region in the siamang, a small ape. Heredity (Edinb). 2012;109:180-7 pubmed publisher
    ..Possible evolutionary scenarios are discussed...
  3. Boeckmann L, Takahashi Y, Au W, Mishra P, Choy J, Dawson A, et al. Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae. Mol Biol Cell. 2013;24:2034-44 pubmed publisher
    ..Taken together, our results provide a detailed analysis, in vivo and in vitro, of Cse4 phosphorylation and its role in promoting faithful chromosome segregation. ..
  4. Zasadzińska E, Barnhart Dailey M, Kuich P, Foltz D. Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition. EMBO J. 2013;32:2113-24 pubmed publisher
    The epigenetic mark of the centromere is thought to be a unique centromeric nucleosome that contains the histone H3 variant, centromere protein-A (CENP-A)...
  5. Qi S, Wang Z, Ouyang Y, Zhang Q, Hu M, Huang X, et al. Overexpression of SET?, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes. J Cell Sci. 2013;126:1595-603 pubmed publisher
    ..SET? accumulation in the nucleus at the germinal vesicle stage, whereas it was targeted mainly to the inner centromere area and faintly localized to the interchromatid axes from germinal vesicle breakdown to MI stages...
  6. Shivaraju M, Unruh J, Slaughter B, Mattingly M, Berman J, Gerton J. Cell-cycle-coupled structural oscillation of centromeric nucleosomes in yeast. Cell. 2012;150:304-16 pubmed publisher
    The centromere is a specialized chromosomal structure that regulates chromosome segregation. Centromeres are marked by a histone H3 variant. In budding yeast, the histone H3 variant Cse4 is present in a single centromeric nucleosome...
  7. Fountzilas G, Dafni U, Bobos M, Kotoula V, Batistatou A, Xanthakis I, et al. Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: pooled analysis of two Hellenic Coo. BMC Cancer. 2013;13:163 pubmed publisher
    ..Limited information exists on the relationship of HER2/TOP2A gene status in the presence of centromere 17 (CEP17) gain with outcome of patients treated with anthracycline-containing adjuvant chemotherapy...
  8. Shang W, Hori T, Martins N, Toyoda A, Misu S, Monma N, et al. Chromosome engineering allows the efficient isolation of vertebrate neocentromeres. Dev Cell. 2013;24:635-48 pubmed publisher
    Centromeres are specified by sequence-independent epigenetic mechanisms in most organisms. Rarely, centromere repositioning results in neocentromere formation at ectopic sites...
  9. Alper B, Lowe B, Partridge J. Centromeric heterochromatin assembly in fission yeast--balancing transcription, RNA interference and chromatin modification. Chromosome Res. 2012;20:521-34 pubmed publisher
  10. Castillo A, Pidoux A, Catania S, Durand Dubief M, Choi E, Hamilton G, et al. Telomeric repeats facilitate CENP-A(Cnp1) incorporation via telomere binding proteins. PLoS ONE. 2013;8:e69673 pubmed publisher
    ..centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined...
  11. Gong Z, Wu Y, Koblizkova A, Torres G, Wang K, Iovene M, et al. Repeatless and repeat-based centromeres in potato: implications for centromere evolution. Plant Cell. 2012;24:3559-74 pubmed publisher
    ..An unknown question in centromere evolution is how satellite repeat-based centromeres evolve from neocentromeres...
  12. Nitta H, Kelly B, Padilla M, Wick N, Brunhoeber P, Bai I, et al. A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections. Diagn Pathol. 2012;7:60 pubmed publisher
    ..Our objective was to combine the US Food and Drug Administration (FDA)-approved HER2 & chromosome 17 centromere (CEN17) brightfield ISH (BISH) and HER2 IHC assays into a single automated HER2 gene-protein assay allowing ..
  13. Schleiffer A, Maier M, Litos G, Lampert F, Hornung P, Mechtler K, et al. CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol. 2012;14:604-13 pubmed publisher
    ..Here we demonstrate that centromere-binding proteins are highly conserved between budding yeast and humans...
  14. Westermann S, Schleiffer A. Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans. Trends Cell Biol. 2013;23:260-9 pubmed publisher
    ..Multiple approaches have converged to identify centromere-associated proteins from yeast to humans...
  15. Natsume T, Müller C, Katou Y, Retkute R, Gierlinski M, Araki H, et al. Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell. 2013;50:661-74 pubmed publisher
    ..Thus, we have found the central mechanism by which kinetochores orchestrate early S phase DNA replication and robust sister chromatid cohesion at microtubule attachment sites...
  16. Gutiérrez Caballero C, Cebollero L, Pendas A. Shugoshins: from protectors of cohesion to versatile adaptors at the centromere. Trends Genet. 2012;28:351-60 pubmed publisher
    ..Here, we compare and contrast these remarkable features of shugoshins in model organisms and humans. ..
  17. Ptacin J, Gahlmann A, Bowman G, Perez A, von Diezmann A, Eckart M, et al. Bacterial scaffold directs pole-specific centromere segregation. Proc Natl Acad Sci U S A. 2014;111:E2046-55 pubmed publisher
    ..that the Caulobacter PopZ scaffold creates an organizing center at the cell pole that actively regulates polar centromere transport by the ParA partition system...
  18. Marsolier Kergoat M. Asymmetry indices for analysis and prediction of replication origins in eukaryotic genomes. PLoS ONE. 2012;7:e45050 pubmed publisher
    ..However, I show here that the skew jumps at C. albicans centromeres are not related to replication and that replication-associated GC and TA skews in C. albicans have in fact the opposite directions of what was proposed. ..
  19. Kouprina N, Samoshkin A, Erliandri I, Nakano M, Lee H, Fu H, et al. Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere. ACS Synth Biol. 2012;1:590-601 pubmed
    ..The knowledge of the alphoid(tetO)-HAC structure provides a tool to control HAC integrity during different manipulations. Our results also shed light on a mechanism for de novo HAC formation in human cells...
  20. Bui M, Dimitriadis E, Hoischen C, An E, Quénet D, Giebe S, et al. Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo. Cell. 2012;150:317-26 pubmed publisher
    ..Our results reveal a cyclical nature to CENP-A nucleosome structure and have implications for the maintenance of epigenetic memory after centromere replication.
  21. Luo S, MACH J, Abramson B, Ramirez R, Schurr R, Barone P, et al. The cotton centromere contains a Ty3-gypsy-like LTR retroelement. PLoS ONE. 2012;7:e35261 pubmed publisher
    The centromere is a repeat-rich structure essential for chromosome segregation; with the long-term aim of understanding centromere structure and function, we set out to identify cotton centromere sequences...
  22. Sato H, Masuda F, Takayama Y, Takahashi K, Saitoh S. Epigenetic inactivation and subsequent heterochromatinization of a centromere stabilize dicentric chromosomes. Curr Biol. 2012;22:658-67 pubmed publisher
    The kinetochore is a multiprotein complex that forms on a chromosomal locus designated as the centromere, which links the chromosome to the spindle during mitosis and meiosis...
  23. Lochmann B, Ivanov D. Histone H3 localizes to the centromeric DNA in budding yeast. PLoS Genet. 2012;8:e1002739 pubmed publisher
    ..Our results favor a H3-Cse4 heterotypic octamer at the budding yeast centromere. Whether or not our model is correct, any future model will have to account for the stable association of ..
  24. Kim I, Lee M, Park K, Jeon Y, Park J, Hwang E, et al. Roles of Mis18? in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell. 2012;46:260-73 pubmed publisher
    ..of a histone H3 variant, centromeric protein A (CENP-A), which is responsible for the specification of centromere identity in the chromosome. However, the functional role of Mis18 complex is largely unknown...
  25. Carbone L, Harris R, Mootnick A, Milosavljevic A, Martin D, Rocchi M, et al. Centromere remodeling in Hoolock leuconedys (Hylobatidae) by a new transposable element unique to the gibbons. Genome Biol Evol. 2012;4:648-58 pubmed publisher
    ..The similarity between the two phenomena is consistent with the hypothesis that evolution of the gibbons is characterized by defects in epigenetic repression of TEs, perhaps triggered by interspecific hybridization...
  26. Thakur J, Sanyal K. Efficient neocentromere formation is suppressed by gene conversion to maintain centromere function at native physical chromosomal loci in Candida albicans. Genome Res. 2013;23:638-52 pubmed publisher
    ..CENPA chromatin is epigenetically propagated on unique and different centromere DNA sequences in a pathogenic yeast Candida albicans...
  27. Hou H, Zhou Z, Wang Y, Wang J, Kallgren S, Kurchuk T, et al. Csi1 links centromeres to the nuclear envelope for centromere clustering. J Cell Biol. 2012;199:735-44 pubmed publisher
    ..In this paper, we identified a novel nuclear protein, Csi1, that localized to the site of centromere attachment and interacted with both the inner nuclear envelope SUN domain protein Sad1 and centromeres...
  28. De Rop V, Padeganeh A, Maddox P. CENP-A: the key player behind centromere identity, propagation, and kinetochore assembly. Chromosoma. 2012;121:527-38 pubmed publisher
    ..Here, we summarize the current knowledge and highlight gaps in understanding of the mechanisms controlling epigenetic regulation of chromosome segregation...
  29. Wang H, Bennetzen J. Centromere retention and loss during the descent of maize from a tetraploid ancestor. Proc Natl Acad Sci U S A. 2012;109:21004-9 pubmed publisher
    Although centromere function is highly conserved in eukaryotes, centromere sequences are highly variable...
  30. Pakala S, Nair V, Reddy S, Kumar R. Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization. J Biol Chem. 2012;287:40560-9 pubmed publisher
    ..Although PAK1 regulates cytoskeleton and microtubule dynamics, its role in controlling the functions of MCAK remains unknown...
  31. Chen C, GREENE E, Bowers S, Mellone B. A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila. PLoS ONE. 2012;7:e45094 pubmed publisher
    The relationship between the nucleolus and the centromere, although documented, remains one of the most elusive aspects of centromere assembly and maintenance...
  32. Li P, Petreaca R, Jensen A, Yuan J, Green M, Forsburg S. Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin. Cell Rep. 2013;3:638-45 pubmed publisher
    The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4(KMT1)...
  33. Akiyoshi B, Gull K. Evolutionary cell biology of chromosome segregation: insights from trypanosomes. Open Biol. 2013;3:130023 pubmed publisher
    ..brucei should reveal fundamental requirements for the eukaryotic segregation machinery, and may also provide hints about the origin and evolution of the segregation apparatus...
  34. Müller S, Almouzni G. A network of players in H3 histone variant deposition and maintenance at centromeres. Biochim Biophys Acta. 2014;1839:241-50 pubmed publisher
    ..The mammalian centromere-specific chaperone HJURP represents an interesting paradigm to understand the functioning of this network...
  35. Plaja A, Lloveras E, Martinez Bouzas C, Barreña B, del Campo M, Fernández A, et al. Trisomy 18p caused by a supernumerary marker with a chromosome 13/21 centromere: a possible recurrent chromosome aberration. Am J Med Genet A. 2013;161A:2363-8 pubmed publisher
    ..with a complex supernumerary marker consisting of the entire short arm of chromosome 18 with a chromosome 13/21 centromere. One patient is a girl with a nonsyndromic intellectual disability and the second is a prenatally diagnosed ..
  36. Nechemia Arbely Y, Fachinetti D, Cleveland D. Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly. Exp Cell Res. 2012;318:1353-60 pubmed publisher
    The centromere is the fundamental unit for insuring chromosome inheritance. This complex region has a distinct type of chromatin in which histone H3 is replaced by a structurally different homologue identified in humans as CENP-A...
  37. Bailey A, Panchenko T, Sathyan K, Petkowski J, Pai P, Bai D, et al. Posttranslational modification of CENP-A influences the conformation of centromeric chromatin. Proc Natl Acad Sci U S A. 2013;110:11827-32 pubmed publisher
    ..The location of the centromere on the chromosome is not dependent on DNA sequence, but rather it is epigenetically specified by the histone H3 ..
  38. Stimpson K, Matheny J, Sullivan B. Dicentric chromosomes: unique models to study centromere function and inactivation. Chromosome Res. 2012;20:595-605 pubmed publisher
    ..The molecular basis for centromere inactivation is not well understood, although studies in model organisms and in humans suggest that genomic and ..
  39. Jayaram M, Chang K, Ma C, Huang C, Liu Y, Sau S. Topological similarity between the 2?m plasmid partitioning locus and the budding yeast centromere: evidence for a common evolutionary origin?. Biochem Soc Trans. 2013;41:501-7 pubmed publisher
    ..They include the cohesin complex and the centromere-specific histone H3 variant Cse4. The genetically defined point centromere of S...
  40. Gassmann R, Rechtsteiner A, Yuen K, Muroyama A, Egelhofer T, Gaydos L, et al. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature. 2012;484:534-7 pubmed publisher
    ..The histone H3 variant CENP-A (also known as CenH3) defines centromeres in monocentric organisms, which confine centromere activity to a discrete chromosomal region, and holocentric organisms, which distribute centromere activity along ..
  41. Verdaasdonk J, Vasquez P, Barry R, Barry T, Goodwin S, Forest M, et al. Centromere tethering confines chromosome domains. Mol Cell. 2013;52:819-31 pubmed publisher
    ..Chromosome motion varies in predicted ways along the length of the chromosome, dependent on tethering at the centromere. Detachment of a tether upon inactivation of the centromere results in increased spatial mobility...
  42. Passot F, Calderon V, Fichant G, Lane D, Pasta F. Centromere binding and evolution of chromosomal partition systems in the Burkholderiales. J Bacteriol. 2012;194:3426-36 pubmed publisher
    ..c1, c2, and c3) and one plasmid (pBC), whose compatibility depends on strictly specific interactions of the centromere sequences (parS) with their cognate binding proteins (ParB). However, the Par systems of B...
  43. Tipton A, Wang K, Oladimeji P, Sufi S, Gu Z, Liu S. Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries. BMC Cell Biol. 2012;13:15 pubmed publisher
    ..The molecular players participating in mitosis regulation are still being unravelled experimentally or using in silico methods...
  44. Humphryes N, Leung W, Argunhan B, Terentyev Y, Dvorácková M, Tsubouchi H. The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. PLoS Genet. 2013;9:e1003194 pubmed publisher
    ..We propose that the Ecm11-Gmc2 complex facilitates the assembly of Zip1 and that SUMOylation of Ecm11 is critical for ensuring chromosomal assembly of Zip1, thus suppressing polycomplex formation...
  45. He W, Li Y, Yang D, Song W, Chen X, Liu F, et al. Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma. Eur J Surg Oncol. 2013;39:141-9 pubmed publisher
    b>Centromere protein H (CENP-H) is one of the essential components of the human active kinetochore which close links with carcinogenesis. Its expression and clinical value of prognostic prediction for gastric cancer (GC) is unclear.
  46. Wan J, Subramonian D, Zhang X. SUMOylation in control of accurate chromosome segregation during mitosis. Curr Protein Pept Sci. 2012;13:467-81 pubmed
    ..This review focuses on how SUMOylation regulates the centromere and kinetochore activities to achieve accurate chromosome segregation during mitosis...
  47. Ross B, Rosin L, Thomae A, Hiatt M, Vermaak D, de la Cruz A, et al. Stepwise evolution of essential centromere function in a Drosophila neogene. Science. 2013;340:1211-4 pubmed publisher
    ..domain, followed by alterations that rewired its protein interaction network and led to species-specific centromere localization...
  48. Heckmann S, Macas J, Kumke K, Fuchs J, Schubert V, Ma L, et al. The holocentric species Luzula elegans shows interplay between centromere and large-scale genome organization. Plant J. 2013;73:555-65 pubmed publisher
    ..showed an almost chromosome-wide distribution pattern as expected for a holocentric chromosome and no typical centromere-associated LTR retrotransposons were found either...
  49. Voelkel Meiman K, Moustafa S, Lefrançois P, Villeneuve A, MacQueen A. Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast. PLoS Genet. 2012;8:e1002993 pubmed publisher
    ..Our observations suggest that, after full-length assembly, SC central region exhibits little global turnover but maintains differential assembly dynamics at sites whose distribution is patterned by a recombination landscape...
  50. Raychaudhuri N, Dubruille R, Orsi G, Bagheri H, Loppin B, Lehner C. Transgenerational propagation and quantitative maintenance of paternal centromeres depends on Cid/Cenp-A presence in Drosophila sperm. PLoS Biol. 2012;10:e1001434 pubmed publisher
    In Drosophila melanogaster, as in many animal and plant species, centromere identity is specified epigenetically...
  51. Zhang B, Lv Z, Pang J, Liu Y, Guo X, Fu S, et al. Formation of a functional maize centromere after loss of centromeric sequences and gain of ectopic sequences. Plant Cell. 2013;25:1979-89 pubmed publisher
    The maize (Zea mays) B centromere is composed of B centromere-specific repeats (ZmBs), centromere-specific satellite repeats (CentC), and centromeric retrotransposons of maize (CRM)...
  52. Quenet D, Dalal Y. The CENP-A nucleosome: a dynamic structure and role at the centromere. Chromosome Res. 2012;20:465-79 pubmed publisher
    The centromere is a specialized locus that directs the formation of the kinetochore protein complex for correct chromosome segregation...
  53. Krasikova A, Fukagawa T, Zlotina A. High-resolution mapping and transcriptional activity analysis of chicken centromere sequences on giant lampbrush chromosomes. Chromosome Res. 2012;20:995-1008 pubmed publisher
    Exploration into morphofunctional organisation of centromere DNA sequences is important for understanding the mechanisms of kinetochore specification and assembly...
  54. Beeharry N, Rattner J, Caviston J, Yen T. Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override. Cell Cycle. 2013;12:1588-97 pubmed publisher
    ..Our studies show that kinetochore and centromere fragmentation is a defining feature of checkpoint override and suggests that loss of cell viability is due in ..
  55. Catez F, Picard C, Held K, Gross S, Rousseau A, Theil D, et al. HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons. PLoS Pathog. 2012;8:e1002852 pubmed publisher
    ..This study demonstrates that nuclear domains including PML-NBs and centromeres are functionally involved in the control of HSV-1 latency, and represent a key level of host/virus interaction...
  56. Hara T, Hirai Y, Jahan I, Hirai H, Koga A. Tandem repeat sequences evolutionarily related to SVA-type retrotransposons are expanded in the centromere region of the western hoolock gibbon, a small ape. J Hum Genet. 2012;57:760-5 pubmed publisher
    ..Thus, the large-scale tandem repeats in the centromere region may have been derived from one or more of SVA-type transposons, including the three mentioned above and ..
  57. Gent J, Dawe R. RNA as a structural and regulatory component of the centromere. Annu Rev Genet. 2012;46:443-53 pubmed publisher
    ..We also review literature suggesting that the process of centromeric transcription may be as important as the resulting RNA and that such transcription may be involved in recruiting the centromeric histone variant CENH3...
  58. Earnshaw W, Allshire R, Black B, Bloom K, Brinkley B, Brown W, et al. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013;21:101-6 pubmed publisher
    ..we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
  59. Fachinetti D, Folco H, Nechemia Arbely Y, Valente L, Nguyen K, Wong A, et al. A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol. 2013;15:1056-66 pubmed publisher
    The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark...
  60. Chan F, Wong L. Transcription in the maintenance of centromere chromatin identity. Nucleic Acids Res. 2012;40:11178-88 pubmed publisher
    Recent evidence has shown that transcription is permissible through the purportedly repressive centromere domain, and that this transcriptional activity is of functional consequence...
  61. Birchler J, Presting G. Retrotransposon insertion targeting: a mechanism for homogenization of centromere sequences on nonhomologous chromosomes. Genes Dev. 2012;26:638-40 pubmed publisher
    ..Recent work in species in which centromere-enriched retrotransposons occur indicates that these elements preferentially insert into the centromeric regions...
  62. Carmena M, Wheelock M, Funabiki H, Earnshaw W. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012;13:789-803 pubmed publisher
    ..Aurora B is one of the most intensively studied kinases. In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC)...
  63. Wang F, Ulyanova N, Daum J, Patnaik D, Kateneva A, Gorbsky G, et al. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol. 2012;199:251-68 pubmed publisher
    ..Haspin inhibitors decreased H3T3ph, resulting in loss of centromeric Aurora B and reduced phosphorylation of centromere and kinetochore Aurora B substrates...
  64. Carlsten J, Szilagyi Z, Liu B, López M, Szászi E, Djupedal I, et al. Mediator promotes CENP-a incorporation at fission yeast centromeres. Mol Cell Biol. 2012;32:4035-43 pubmed publisher
    ..Control of centromeric ncRNA transcription is therefore a key factor for proper centromere function...
  65. Pohl T, Brewer B, Raghuraman M. Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae. PLoS Genet. 2012;8:e1002677 pubmed publisher
    ..Surprisingly, little is known about the biological significance or the mechanism of early centromere replication; however, the extensive conservation suggests that it is important for chromosome maintenance...
  66. Hayden K, Willard H. Composition and organization of active centromere sequences in complex genomes. BMC Genomics. 2012;13:324 pubmed publisher
    Centromeres are sites of chromosomal spindle attachment during mitosis and meiosis. While the sequence basis for centromere identity remains a subject of considerable debate, one approach is to examine the genomic organization at these ..
  67. Iwanaga S, Kato T, Kaneko I, Yuda M. Centromere plasmid: a new genetic tool for the study of Plasmodium falciparum. PLoS ONE. 2012;7:e33326 pubmed publisher
    ..To improve the genetic manipulation of P. falciparum, we developed the centromere plasmid as a new genetic tool. First, we attempted to clone all of the predicted centromeres from P...
  68. Dong Q, Han F. Phosphorylation of histone H2A is associated with centromere function and maintenance in meiosis. Plant J. 2012;71:800-9 pubmed publisher
    ..for Thr133-phosphorylated histone H2A, which is important for spindle checkpoint control and localization of the centromere cohesion protector Shugoshin in mammals and yeast...
  69. Dambacher S, Deng W, Hahn M, Sadic D, Frohlich J, Nuber A, et al. CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin. Nucleus. 2012;3:101-10 pubmed publisher
    ..A fundamental process in centromere establishment is the incorporation of the histone variant CENP-A into centromeric chromatin, which provides a ..
  70. Rouzeau S, Cordelières F, Buhagiar Labarchède G, Hurbain I, Onclercq Delic R, Gemble S, et al. Bloom's syndrome and PICH helicases cooperate with topoisomerase II? in centromere disjunction before anaphase. PLoS ONE. 2012;7:e33905 pubmed publisher
    ..we showed that both BLM-deficient and PICH-deficient prometaphase cells displayed changes in centromere structure...
  71. Valente L, Silva M, Jansen L. Temporal control of epigenetic centromere specification. Chromosome Res. 2012;20:481-92 pubmed publisher
    ..The centromere is a unique locus on each chromosome that supports a multiprotein structure called the kinetochore...
  72. Hall L, Mitchell S, O Neill R. Pericentric and centromeric transcription: a perfect balance required. Chromosome Res. 2012;20:535-46 pubmed publisher
    The pericentromere and centromere regions of the genome have previously been considered tightly compacted and transcriptionally inert...
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    Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown...
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    The centromere is the chromosomal locus that ensures fidelity in genome transmission at cell division. Centromere protein A (CENP-A) is a histone H3 variant that specifies centromere location independently of DNA sequence...
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    ..and have asymmetric nuclei which make them a unique model for localizing CHR territories and matching peri-centromere domains...
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    ..In binding to centromere sequences, ParB assembles as nucleoprotein structures called partition complexes...
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    ..Cohesin is most concentrated in the pericentromere, the region surrounding the centromere [10-15]. Enriched pericentromeric cohesin requires the Ctf19 kinetochore subcomplex in budding yeast [16-18]...
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    The centromere is a specialized chromosomal region that serves as the assembly site of the kinetochore. At the centromere, CENP-A nucleosomes form part of a chromatin landscape termed centrochromatin...
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    The centromere is a chromosomal structure that is essential for the accurate segregation of replicated eukaryotic chromosomes to daughter cells...
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    The centromere is the part of the chromosome that organizes the kinetochore, which mediates chromosome movement during mitosis and meiosis...