chromosome structures

Summary

Summary: Structures which are contained in or part of CHROMOSOMES.

Top Publications

  1. Maeshima K, Eltsov M, Laemmli U. Chromosome structure: improved immunolabeling for electron microscopy. Chromosoma. 2005;114:365-75 pubmed
    ..The data obtained are consistent with the view that condensin and perhaps topoIIalpha tether chromatin to loops according to a scaffolding-type model...
  2. Fukui K. Structural analyses of chromosomes and their constituent proteins. Cytogenet Genome Res. 2009;124:215-27 pubmed publisher
    ..Finally, it is concluded that further advances in chromosome research are necessary to solve an enigma lasting nearly two centuries, that is, why chromosomes retain the same shape in plants and animals...
  3. Chan R, Severson A, Meyer B. Condensin restructures chromosomes in preparation for meiotic divisions. J Cell Biol. 2004;167:613-25 pubmed
    ..The safeguarding of chromosome resolution by condensin permits chromosome segregation and is crucial for the formation of discrete, individualized bivalent chromosomes...
  4. Strukov Y, Wang Y, Belmont A. Engineered chromosome regions with altered sequence composition demonstrate hierarchical large-scale folding within metaphase chromosomes. J Cell Biol. 2003;162:23-35 pubmed
    ..Our results contradict predictions of simple radial loop models and provide the first unambiguous demonstration of a hierarchical folding subunit above the level of the 30-nm fiber within normally condensed metaphase chromosomes...
  5. Matsuda A, Shao L, Boulanger J, Kervrann C, Carlton P, Kner P, et al. Condensed mitotic chromosome structure at nanometer resolution using PALM and EGFP- histones. PLoS ONE. 2010;5:e12768 pubmed publisher
    ..As demonstrated by modeling and experiments on a challenging specimen, the techniques described here facilitate super-resolution fluorescent imaging with common biological samples...
  6. Watanabe J, Uehara K, Mogi Y. Diversity of mating-type chromosome structures in the yeast Zygosaccharomyces rouxii caused by ectopic exchanges between MAT-like loci. PLoS ONE. 2013;8:e62121 pubmed publisher
    ..These results suggest that the MAT and MAT-like loci were the susceptible regions in the genome, and the diversity of mating-type chromosome structures in Z. rouxii was caused by ectopic exchanges between MAT-like loci.
  7. Toro E, Shapiro L. Bacterial chromosome organization and segregation. Cold Spring Harb Perspect Biol. 2010;2:a000349 pubmed publisher
    ..Active segregation by a mitotic machinery appears to be common; however, the mode of chromosome segregation varies significantly from species to species...
  8. Mehta G, Jalan R, Mookerjee R. Cracking the ENCODE: from transcription to therapeutics. Hepatology. 2013;57:2532-5 pubmed publisher
    ..Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research. ..
  9. Nitiss J. DNA topoisomerase II and its growing repertoire of biological functions. Nat Rev Cancer. 2009;9:327-37 pubmed publisher

More Information

Publications89

  1. Saifitdinova A, Derjusheva S, Krasikova A, Gaginskaya E. Lampbrush chromosomes of the chaffinch (Fringilla coelebs L.). Chromosome Res. 2003;11:99-113 pubmed
  2. Hari K, Cook K, Karpen G. The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family. Genes Dev. 2001;15:1334-48 pubmed
    ..We propose that Su(var2-10 controls multiple aspects of chromosome structure and function by establishing/maintaining chromosome organization in interphase nuclei. ..
  3. Zhang Y, Cheng C, Li J, Yang S, Wang Y, Li Z, et al. Chromosomal structures and repetitive sequences divergence in Cucumis species revealed by comparative cytogenetic mapping. BMC Genomics. 2015;16:730 pubmed publisher
    ..b>Chromosome structures of five Cucumis species were investigated using GISH and comparative mapping of specific satellites...
  4. Tanay A, Cavalli G. Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization. Curr Opin Genet Dev. 2013;23:197-203 pubmed publisher
    ..Specifically, we hypothesize that domains are facilitating genomic compartmentalization that support the implementation of complex, modular, and tissue specific transcriptional program in metazoa. ..
  5. Saberi S, Emberly E. Chromosome driven spatial patterning of proteins in bacteria. PLoS Comput Biol. 2010;6:e1000986 pubmed publisher
    ..The model also suggests new experiments to further test the role of the chromosome in driving protein patterning, and whether such a mechanism is responsible for helping to drive the differentiation of the cell poles. ..
  6. Toni L, Padilla P. Developmentally arrested Austrofundulus limnaeus embryos have changes in post-translational modifications of histone H3. J Exp Biol. 2016;219:544-52 pubmed publisher
    ..limnaeus is a unique model to study epigenetic features associated with embryonic arrest. To investigate chromosome structures associated with mitosis or gene expression, we examined the post-translational modifications of histone H3 ..
  7. Zlotina A, Kulikova T, Kosyakova N, Liehr T, Krasikova A. Microdissection of lampbrush chromosomes as an approach for generation of locus-specific FISH-probes and samples for high-throughput sequencing. BMC Genomics. 2016;17:126 pubmed publisher
    ..For investigation of RNA-content of lampbrush chromosome structures, samples retrieved by microdissection were subjected to reverse transcription...
  8. Bickmore W, van Steensel B. Genome architecture: domain organization of interphase chromosomes. Cell. 2013;152:1270-84 pubmed publisher
  9. Joti Y, Hikima T, Nishino Y, Kamada F, Hihara S, Takata H, et al. Chromosomes without a 30-nm chromatin fiber. Nucleus. 2012;3:404-10 pubmed publisher
    ..Our findings suggest a common structural feature in interphase and mitotic chromatins: compact and irregular folding of nucleosome fibers occurs without a 30-nm chromatin structure. ..
  10. Glockner G, Heidel A. Centromere sequence and dynamics in Dictyostelium discoideum. Nucleic Acids Res. 2009;37:1809-16 pubmed publisher
    ..In addition to insights into the centromere organization and dynamics of a protist eukaryote, this work also provides a starting point for the analysis of the evolution of centromere structures in social amoebas by comparative genomics. ..
  11. Sampath S, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004;118:187-202 pubmed publisher
    ..We propose that the chromosomal passenger complex regulates local MCAK activity to permit spindle formation via stabilization of chromatin-associated microtubules...
  12. Oda H, Okamoto I, Murphy N, Chu J, Price S, Shen M, et al. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol. 2009;29:2278-95 pubmed publisher
    ..Most importantly, the lack of H4K20me1 also resulted in defects in chromosome condensation in interphase nuclei. These results demonstrate the critical role of H4K20 monomethylation in mammals in a developmental context. ..
  13. Kauppi L, Jasin M, Keeney S. The tricky path to recombining X and Y chromosomes in meiosis. Ann N Y Acad Sci. 2012;1267:18-23 pubmed publisher
    ..These findings imply that spermatocytes have evolved distinct strategies that ensure successful X-Y recombination and chromosome segregation. ..
  14. Zhang T, Lim H, Cheng C, Surana U. Deficiency of centromere-associated protein Slk19 causes premature nuclear migration and loss of centromeric elasticity. J Cell Sci. 2006;119:519-31 pubmed
    ..Our results suggest that Slk19 participates in regulating nuclear migration and, in conjunction with cohesin complex, may be involved in the maintenance of centromeric tensile strength to resist the pole-ward pull. ..
  15. Zhang Z, Kwiatkowski N, Zeng H, Lim S, Gray N, Zhang W, et al. Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy. Mol Biosyst. 2012;8:2523-6 pubmed publisher
    ..Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy. ..
  16. Sun H, Wu S, Zhang G, Jiao C, Guo S, Ren Y, et al. Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes. Mol Plant. 2017;10:1293-1306 pubmed publisher
    ..maxima and C. moschata diverged. The subgenomes have largely maintained the chromosome structures of their diploid progenitors...
  17. Masuda T, Xu X, Dimitriadis E, Lahusen T, Deng C. "DNA Binding Region" of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint. Int J Biol Sci. 2016;12:133-43 pubmed publisher
    ..The ΔDBR cells also exhibited an increased number of abnormal chromosome structures as compared with WT cells, indicating that the ΔDBR cells have increased genetic instability...
  18. Ventura M, Catacchio C, Alkan C, Marques Bonet T, Sajjadian S, Graves T, et al. Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. Genome Res. 2011;21:1640-9 pubmed publisher
    ..Our analysis suggests that the chimpanzee and gorilla genomes are structurally more derived than either orangutan or human genomes...
  19. Fu J, Bian M, Liu J, Jiang Q, Zhang C. A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A. 2009;106:6939-44 pubmed publisher
    ..Therefore, we propose that the presence of Gly or Asn at a single site assigns Aurora-A and -B to their respective partners and thus to their distinctive subcellular localizations and functions. ..
  20. Jin T, Li J, Guo Y, Zhou X, Yang R, Wu R. An optimal strategy for functional mapping of dynamic trait loci. Genet Res (Camb). 2010;92:55-62 pubmed publisher
    ..Under this combination, several significant QTLs for leaf age growth trajectories were detected on different chromosomes. Our model can be well used to study the genetic architecture of dynamic traits of agricultural values. ..
  21. Lavoie B. pRb and condensin--local control of global chromosome structure. Genes Dev. 2008;22:964-9 pubmed publisher
    ..This work directly implicates the Rb family proteins in mitotic chromosome condensation and suggests that a failure in targeting condensin II to chromatin underlies the aneuploidy in rbf1 mutants. ..
  22. Sumida M, Ohta S, Atsumi S, Fujii T. Geographic variability in expression of the sex-linked AAT-1 gene of the bell-ring frog, Buergeria buergeri. J Exp Zool B Mol Dev Evol. 2004;302:182-94 pubmed
    ..These two modes of expression may be widely distributed in western and eastern Japan, and coexist in the central part of Honshu. ..
  23. Spurbeck J, Adams S, Stupca P, Dewald G. Primer on medical genomics. Part XI: Visualizing human chromosomes. Mayo Clin Proc. 2004;79:58-75 pubmed
    ..The clinical diagnosis, prognosis, and response to treatment can be established for many malignant diseases. Cytogenetic methods provide an important diagnostic tool for clinical practice. ..
  24. Min Oo G, Willemetz A, Tam M, Canonne Hergaux F, Stevenson M, Gros P. Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9. Genes Immun. 2010;11:113-23 pubmed publisher
    ..AcB62 alleles at both loci are associated with higher peak parasitemia. These results identify Char10 as a novel locus modulating severity of malaria in the context of PK deficiency. ..
  25. Martin G, Carreel F, Coriton O, Hervouet C, Cardi C, Derouault P, et al. Evolution of the Banana Genome (Musa acuminata) Is Impacted by Large Chromosomal Translocations. Mol Biol Evol. 2017;34:2140-2152 pubmed publisher
    ..The two chromosome structures were found to be mutually exclusive in gametes and the rearranged structure was preferentially transmitted ..
  26. Pampalona J, Soler D, Genesca A, Tusell L. Telomere dysfunction and chromosome structure modulate the contribution of individual chromosomes in abnormal nuclear morphologies. Mutat Res. 2010;683:16-22 pubmed publisher
    ..Few micronuclei emerged in this cell system thus validating the scoring of nucleoplasmic bridges and nuclear buds for measuring chromosome instability in telomere-dysfunction cell environments...
  27. Valenzuela C. Selective intra-dinucleotide interactions and periodicities of bases separated by K sites: a new vision and tool for phylogeny analyses. Biol Res. 2017;50:3 pubmed publisher
    ..An example is provided. ..
  28. Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
  29. Mun J, Kwon S, Seol Y, Kim J, Jin M, Kim J, et al. Sequence and structure of Brassica rapa chromosome A3. Genome Biol. 2010;11:R94 pubmed publisher
    ..Therefore, its genome sequence will be used to accelerate both basic research on genome evolution and applied research across the cultivated Brassica species...
  30. Lyubetsky V, Gershgorin R, Gorbunov K. Chromosome structures: reduction of certain problems with unequal gene content and gene paralogs to integer linear programming. BMC Bioinformatics. 2017;18:537 pubmed publisher
    ..In the reconstruction problem, a phylogenetic tree with chromosome structures in the leaves is given...
  31. Tanifuji G, Onodera N, Wheeler T, Dlutek M, Donaher N, Archibald J. Complete nucleomorph genome sequence of the nonphotosynthetic alga Cryptomonas paramecium reveals a core nucleomorph gene set. Genome Biol Evol. 2011;3:44-54 pubmed publisher
    ..This result suggests that similar reductive processes have taken place in unrelated lineages of nucleomorph-containing algae...
  32. Daban J. Electron microscopy and atomic force microscopy studies of chromatin and metaphase chromosome structure. Micron. 2011;42:733-50 pubmed publisher
    ..The multilaminar chromatin structure proposed for chromosomes allows an easy explanation of chromosome banding and of the band splitting observed in stretched chromosomes...
  33. Coyne R, Stover N, Miao W. Whole genome studies of Tetrahymena. Methods Cell Biol. 2012;109:53-81 pubmed publisher
    ..Future studies of Tetrahymena cell and molecular biology, development, physiology, evolution and ecology will benefit greatly from these resources and the advanced genomic technologies they enable...
  34. Viera A, Gómez R, Parra M, Schmiesing J, Yokomori K, Rufas J, et al. Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. PLoS ONE. 2007;2:e783 pubmed
    ..Additionally, we present the relative distribution of the condensin I and cohesin complexes in metaphase I bivalents. All these new data have allowed us to propose a comprehensive model for meiotic chromosome structure...
  35. Eivazova E, Vassetzky Y, Aune T. Selective matrix attachment regions in T helper cell subsets support loop conformation in the Ifng gene. Genes Immun. 2007;8:35-43 pubmed
    ..The data suggest that such structural dynamics provide the means for transcriptional regulation of the Ifng gene in the course of activation and differentiation of CD4+Th cells...
  36. Liu X, Sugiyama S, Xu Q, Kobori T, Hagiwara S, Ohtani T. Atomic force microscopy study of chromosome surface structure changed by protein extraction. Ultramicroscopy. 2003;94:217-23 pubmed
    ..The results demonstrate the advantage of the combined method of high-resolution AFM imaging and chemical treatments for understanding nano-scale surface structures of the chromosome...
  37. Gibaud A, Vogt N, Hadj Hamou N, Meyniel J, Hupe P, Debatisse M, et al. Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci. Hum Mol Genet. 2010;19:1276-85 pubmed publisher
    ..The nature of the sequences involved in these rearrangements suggests that a V(D)J-like illegitimate recombination contributes to its formation...
  38. Mulle J. Genomic structural variation and schizophrenia. Curr Psychiatry Rep. 2008;10:171-7 pubmed
    ..Although much optimism surrounds this burgeoning field, the technical challenges in reliably identifying structural variation mean recent literature should be approached with caution...
  39. Crawley O, Barroso C, Testori S, Ferrandiz N, Silva N, Castellano Pozo M, et al. Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes. elife. 2016;5:e10851 pubmed publisher
    ..Surprisingly, a WAPL-1-independent mechanism removes cohesin before metaphase I. Our studies provide insight into how meiosis-specific cohesin complexes are regulated to ensure formation of euploid gametes. ..
  40. Xia J, Wu L. [Prenatal diagnosis and genetic counseling]. Zhonghua Fu Chan Ke Za Zhi. 2003;38:474-7 pubmed
  41. Wang X. [Cytogenetic study on 155 cases of non-Hodgkin' s lymphoma]. Zhonghua Xue Ye Xue Za Zhi. 2006;27:656-60 pubmed
    ..To investigate the relationship between histopathological subtype of non-Hodgkin' s lymphoma(NHL) and chromosomal abnormalities, and compare the difference of chromosomal abnormalities between China and the West...
  42. Krasikova A, Kulikova T, Saifitdinova A, Derjusheva S, Gaginskaya E. Centromeric protein bodies on avian lampbrush chromosomes contain a protein detectable with an antibody against DNA topoisomerase II. Chromosoma. 2004;113:316-23 pubmed
    ..We propose that the smaller protein results from oocyte specific topo II cleavage, since it was not detected in nuclei from testis cells. This represents the first report of a defined protein in the centromeric PBs on avian LBCs...
  43. Aragon L, Martinez Perez E, Merkenschlager M. Condensin, cohesin and the control of chromatin states. Curr Opin Genet Dev. 2013;23:204-11 pubmed publisher
    ..Here we look at the emerging role of these complexes in regulating chromatin structure and gene expression and reflect on how these activities could be linked with chromosome topology...
  44. Van Hooser A, Yuh P, Heald R. The perichromosomal layer. Chromosoma. 2005;114:377-88 pubmed
    ..We review the identified proteins associated with this chromosome domain and briefly discuss their known functions during interphase and mitosis...
  45. Cremer T, Cremer M, Dietzel S, Muller S, Solovei I, Fakan S. Chromosome territories--a functional nuclear landscape. Curr Opin Cell Biol. 2006;18:307-16 pubmed
  46. Kusakabe T, Sugimoto Y, Hirota Y, Tone S, Kawaguchi Y, Koga K, et al. Isolation of replicational cue elements from a library of bent DNAs of Aspergillus oryzae. Mol Biol Rep. 2000;27:13-9 pubmed
    ..This plasmid carrying the cue fragment could also replicate in HeLa and NIH3T3 cells...
  47. Barrington C, Pezic D, Hadjur S. Chromosome structure dynamics during the cell cycle: a structure to fit every phase. EMBO J. 2017;36:2661-2663 pubmed publisher
  48. Gschwend A, Weingartner L, Moore R, Ming R. The sex-specific region of sex chromosomes in animals and plants. Chromosome Res. 2012;20:57-69 pubmed publisher
    ..Most X-linked microRNA genes escape silencing and are expressed in testis. Collectively, these findings are challenging many of our preconceived ideas of the evolutionary trajectory and fates of sex chromosomes...
  49. Splinter E, de Wit E, Nora E, Klous P, van de Werken H, Zhu Y, et al. The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA. Genes Dev. 2011;25:1371-83 pubmed publisher
    ..Our data point to a role for Xist RNA in shaping the conformation of the inactive X chromosome at least partially independent of transcription...
  50. Heyd F, Lynch K. Degrade, move, regroup: signaling control of splicing proteins. Trends Biochem Sci. 2011;36:397-404 pubmed publisher
    ..These include regulated synthesis or degradation of splicing factors, differential protein-protein interactions, altered nuclear translocation and changes in transcription elongation...
  51. Wu Y, Xia X, Huang Y. [Progress on the detection techniques for DNA integrity of sperm]. Zhonghua Nan Ke Xue. 2006;12:737-41 pubmed
    ..This review attempts at a detailed description of these detection techniques, including their principles, methods, steps and clinical application...
  52. Lunyak V. Boundaries. Boundaries...Boundaries???. Curr Opin Cell Biol. 2008;20:281-7 pubmed publisher
    ..Rule 19 (a) (Boundaries)"Before the toss, the umpires shall agree the boundary of the field of play with both captains. The boundary shall, if possible, be marked along its whole length" Rules of Cricket...
  53. Wu Y, Jiang Y, Wang X, Wang H, Wang J, Yang Y, et al. [Detection of subtelomeric rearrangements in patients with idiopathic mental retardation/developmental delay]. Zhonghua Er Ke Za Zhi. 2007;45:906-11 pubmed
    ..To detect subtelomeric rearrangement in patients with idiopathic mental retardation/developmental delays (MR/DD) and to provide new methods and evidence for the etiologic diagnosis of MR/DD in China...
  54. Sahara K, Yoshido A, Traut W. Sex chromosome evolution in moths and butterflies. Chromosome Res. 2012;20:83-94 pubmed publisher
    ..It is crammed with repetitive elements which appear to have a high turnover rate but poor in or even devoid of protein-coding genes. It has frequently undergone fusion with autosomes or sporadically lost altogether...
  55. Krasikova A, Barbero J, Gaginskaya E. Cohesion proteins are present in centromere protein bodies associated with avian lampbrush chromosomes. Chromosome Res. 2005;13:675-85 pubmed
    ..These results indicate that cohesion proteins accumulate in centromere PBs in avian oocytes and are involved into structural maintenance of lampbrush chromosome axes...
  56. Müssig K, Machicao F, Machann J, Schick F, Claussen C, Stefan N, et al. No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes. BMC Med Genet. 2010;11:84 pubmed publisher
  57. Germe T, Hyrien O. Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure. EMBO Rep. 2005;6:729-35 pubmed
    ..Chromatin perturbation by topo II clamps may explain some dominant cellular effects of ICRF-193. Nucleosome-driven bending of precatenane nodes may facilitate their unlinking by topo II during unperturbed replication...
  58. Cremer T, Cremer C. Rise, fall and resurrection of chromosome territories: a historical perspective. Part II. Fall and resurrection of chromosome territories during the 1950s to 1980s. Part III. Chromosome territories and the functional nuclear architecture: experiments. Eur J Histochem. 2006;50:223-72 pubmed
  59. Vallet Gely I, Boccard F. Chromosomal organization and segregation in Pseudomonas aeruginosa. PLoS Genet. 2013;9:e1003492 pubmed publisher
    ..We also showed that disrupting the ParABS system is very detrimental in P. aeruginosa. Possible mechanisms responsible for the coordinated chromosomal segregation process and for the presence of large distinctive regions are discussed...
  60. Shintomi K, Hirano T. The relative ratio of condensin I to II determines chromosome shapes. Genes Dev. 2011;25:1464-9 pubmed publisher
    ..Cohesin helps juxtapose sister chromatid arms by collaborating with condensin I and counteracting condensin II. Thus, chromosome shaping is achieved by an exquisite balance among condensin I and II and cohesin...
  61. Cuvier O, Hirano T. A role of topoisomerase II in linking DNA replication to chromosome condensation. J Cell Biol. 2003;160:645-55 pubmed
    ..Our results suggest that topo II plays an important role in an early stage of chromosome condensation, and that this function of topo II is tightly coupled with prior DNA replication...
  62. Shopland L, Johnson C, Byron M, McNeil J, Lawrence J. Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods. J Cell Biol. 2003;162:981-90 pubmed
    ..quot;..
  63. Basit S, Ali G, Wasif N, Ansar M, Ahmad W. Genetic mapping of a novel hypotrichosis locus to chromosome 7p21.3-p22.3 in a Pakistani family and screening of the candidate genes. Hum Genet. 2010;128:213-20 pubmed publisher
    ..59 Mb according to the sequence-based physical map (Build 36.2). Mutation analysis of five potential candidate genes (GNA12, FOXK1, DAGLB, ZNF12, ACTB), located in the linkage interval, did not reveal any functional sequence variant...
  64. Bubulya P, Spector D. "On the move"ments of nuclear components in living cells. Exp Cell Res. 2004;296:4-11 pubmed
    ..In this review we focus on recent advances related to the dynamics of chromatin domains, as well as the dynamics of nuclear proteins and several nuclear organelles...
  65. Li D, Zhang H, Wang R, Zhu H, Li L, Liu R. Chromosomal abnormalities in men with pregestational and gestational infertility in northeast China. J Assist Reprod Genet. 2012;29:829-36 pubmed publisher
    ..To detect incidences and the types of chromosomal abnormalities in Chinese men with infertility and determine chromosomal factors association with various phenotypes...
  66. Murata C, Yamada F, Kawauchi N, Matsuda Y, Kuroiwa A. The Y chromosome of the Okinawa spiny rat, Tokudaia muenninki, was rescued through fusion with an autosome. Chromosome Res. 2012;20:111-25 pubmed publisher
    ..osimensis and T. tokunoshimensis, through fusion with an autosome. Despite retaining the Y chromosome, sex determination in T. muenninki might not follow the usual mammalian pattern and deserves further investigation...
  67. Gazave E, Darré F, Morcillo Suarez C, Petit Marty N, Carreño A, Marigorta U, et al. Copy number variation analysis in the great apes reveals species-specific patterns of structural variation. Genome Res. 2011;21:1626-39 pubmed publisher
    ..Finally, we identified a number of interesting genomic regions that present high-frequency CNVs in all great apes, while containing only very rare or even pathogenic structural variants in humans...
  68. Li X, Slayton W. Molecular mechanisms of platelet and stem cell rebound after 5-fluorouracil treatment. Exp Hematol. 2013;41:635-645.e3 pubmed publisher
    ..Microarray studies demonstrated that up-regulation of the angiopoietin-1/Tie2 signaling pathway coincided with platelet rebound. 7. Suppression of genes involved in chromosomal organization coincided with stem cell and platelet rebound. ..
  69. Snell G, Higgins G. Alleles at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Genetics. 1951;36:306-10 pubmed
  70. Parada L, Sotiriou S, Misteli T. Spatial genome organization. Exp Cell Res. 2004;296:64-70 pubmed
    ..Here we discuss potential functional consequences of spatial genome organization and we speculate on the possible molecular mechanisms of how genomes are organized within the space of the mammalian cell nucleus...
  71. Hu B, Liao C, Millson S, Mollapour M, Prodromou C, Pearl L, et al. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Mol Microbiol. 2005;55:1735-50 pubmed
    ..This could imply a role for Nse4 in maintenance of higher order chromosome structure...
  72. Dolezel J, Vrana J, Safar J, Bartos J, Kubaláková M, Simkova H. Chromosomes in the flow to simplify genome analysis. Funct Integr Genomics. 2012;12:397-416 pubmed publisher
    ..This review explains the principles of flow cytometric chromosome analysis and sorting (flow cytogenetics), discusses the major uses of this technology in genome analysis, and outlines future directions...
  73. Cimini D, Mattiuzzo M, Torosantucci L, Degrassi F. Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Mol Biol Cell. 2003;14:3821-33 pubmed
  74. Giménez Abián J, Clarke D. Replication-coupled topoisomerase II templates the mitotic chromosome scaffold?. Cell Cycle. 2003;2:230-2 pubmed
  75. Chindera K, Mahato M, Sharma A, Horsley H, Kloc Muniak K, Kamaruzzaman N, et al. The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes. Sci Rep. 2016;6:23121 pubmed publisher
    ..Because acquired resistance to PHMB has not been reported, selective chromosome condensation provides an unanticipated paradigm for antimicrobial action that may not succumb to resistance. ..
  76. Kazama Y, Sugiyama R, Suto Y, Uchida W, Kawano S. The clustering of four subfamilies of satellite DNA at individual chromosome ends in Silene latifolia. Genome. 2006;49:520-30 pubmed
    ..The satDNA has not been completely homogenized in the S. latifolia genome. Each subfamily is available for a probe of FISH karyotyping...
  77. Leshner M, Devine M, Roloff G, True L, Misteli T, Meaburn K. Locus-specific gene repositioning in prostate cancer. Mol Biol Cell. 2016;27:236-46 pubmed publisher
    ..Our data point to locus-specific reorganization of the genome during prostate disease. ..
  78. Jasencakova Z, Soppe W, Meister A, Gernand D, Turner B, Schubert I. Histone modifications in Arabidopsis- high methylation of H3 lysine 9 is dispensable for constitutive heterochromatin. Plant J. 2003;33:471-80 pubmed
    ..Thus, a high level of H3methylK9 is apparently not necessary to maintain chromocenter structure and does not prevent methylation of H3 lysine 4 within Arabidopsis chromocenters...
  79. Schalbetter S, Goloborodko A, Fudenberg G, Belton J, Miles C, Yu M, et al. SMC complexes differentially compact mitotic chromosomes according to genomic context. Nat Cell Biol. 2017;19:1071-1080 pubmed publisher
    ..Our results argue that the conserved mechanism of SMC complexes is to form chromatin loops and that distinct SMC-dependent looping activities are selectively deployed to appropriately compact chromosomes...
  80. Scialdone A, Nicodemi M. DNA loci cross-talk through thermodynamics. J Biomed Biotechnol. 2009;2009:516723 pubmed publisher
    ..Our studies, while rationalize several experimental observations, result in very interesting and testable predictions...