sarcolemma

Summary

Summary: The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Top Publications

  1. DiFranco M, Vergara J. The Na conductance in the sarcolemma and the transverse tubular system membranes of mammalian skeletal muscle fibers. J Gen Physiol. 2011;138:393-419 pubmed publisher
    ..The quantitative evaluation of the distribution of Na channels between the sarcolemma and the TTS membranes, as provided here, is crucial for the understanding of the radial and longitudinal ..
  2. Fazakerley D, Lawrence S, Lizunov V, Cushman S, Holman G. A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling. J Cell Sci. 2009;122:727-34 pubmed publisher
    ..A distinction between sarcolemma labelling and transverse-tubule labelling has also been possible because the former compartment is much more ..
  3. Amenta A, Yilmaz A, Bogdanovich S, McKechnie B, Abedi M, Khurana T, et al. Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice. Proc Natl Acad Sci U S A. 2011;108:762-7 pubmed publisher
    ..Systemically delivered rhBGN up-regulates utrophin at the sarcolemma and reduces muscle pathology in the mdx mouse model of DMD...
  4. García Pelagio K, Bloch R, Ortega A, Gonzalez Serratos H. Biomechanics of the sarcolemma and costameres in single skeletal muscle fibers from normal and dystrophin-null mice. J Muscle Res Cell Motil. 2011;31:323-36 pubmed publisher
    We studied the biomechanical properties of the sarcolemma and its links through costameres to the contractile apparatus in single mammalian myofibers of Extensor digitorum longus muscles isolated from wild (WT) and dystrophin-null (mdx) ..
  5. Aragão E, Randazzo Moura P, Rostelato Ferreira S, Rodrigues Simioni L, Ward R. Shared structural determinants for the calcium-independent liposome membrane permeabilization and sarcolemma depolarization in Bothropstoxin-I, a LYS49-PLA(2) from the venom of Bothrops jararacussu. Int J Biochem Cell Biol. 2009;41:2588-93 pubmed publisher
    ..Furthermore, a strong correlation is observed between the structural determinants of sarcolemma depolarization and calcium-independent disruption of liposome membranes, suggesting that a common mechanism of ..
  6. Roostalu U, Strahle U. In vivo imaging of molecular interactions at damaged sarcolemma. Dev Cell. 2012;22:515-29 pubmed publisher
    ..Thus, sarcolemmal repair relies on the ordered assembly of a protein-membrane scaffold. Moreover, we provide several lines of evidence that the membrane for sarcolemmal repair is derived from a specialized plasma membrane compartment. ..
  7. Ogneva I, Lebedev D, Shenkman B. Transversal stiffness and Young's modulus of single fibers from rat soleus muscle probed by atomic force microscopy. Biophys J. 2010;98:418-24 pubmed publisher
    ..structures that connect the Z-disks and M-bands of a sarcomere to sarcomeres of neighbor myofibrils or to sarcolemma. Mechanical properties of these structures are not well characterized...
  8. Locate S, Colyer J, Gawler D, Walker J. Annexin A6 at the cardiac myocyte sarcolemma--evidence for self-association and binding to actin. Cell Biol Int. 2008;32:1388-96 pubmed publisher
    ..Here we show that annexin A6 copurifies with sarcolemma isolated from pig heart...
  9. Canato M, Dal Maschio M, Sbrana F, Raiteri R, Reggiani C, Vassanelli S, et al. Mechanical and electrophysiological properties of the sarcolemma of muscle fibers in two murine models of muscle dystrophy: col6a1-/- and mdx. J Biomed Biotechnol. 2010;2010:981945 pubmed publisher
    This study aimed to analyse the sarcolemma of Col6a1-/- fibers in comparison with wild type and mdx fibers, taken as positive control in view of the known structural and functional alterations of their membranes...

More Information

Publications69

  1. Zhu Z, Burnett C, Maksymov G, Stepniak E, Sierra A, Subbotina E, et al. Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia. Biochem Biophys Res Commun. 2011;415:637-41 pubmed publisher
  2. Zacharias U, Purfürst B, Schöwel V, Morano I, Spuler S, Haase H. Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J Muscle Res Cell Motil. 2011;32:271-80 pubmed publisher
    ..Therefore, we investigated whether ahnak would be influenced by alterations of the sarcolemma exemplified by dysferlin mutations known to render the sarcolemma vulnerable or by mutations in calpain3, a ..
  3. Kavazis A, Alvarez S, Talbert E, Lee Y, Powers S. Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins. Am J Physiol Heart Circ Physiol. 2009;297:H144-52 pubmed publisher
    ..Importantly, based on our findings, pharmacological or other interventions could be used to develop a strategy of protecting the myocardium during an ischemic attack...
  4. Lawrence S, Holman G, Koumanov F. Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling. Biochem J. 2010;432:515-23 pubmed publisher
    ..However, we have examined in the present study whether a net translocation of NHE1 to the sarcolemma of cardiomyocytes may also be involved in the activation process...
  5. Gumerson J, Kabaeva Z, Davis C, Faulkner J, Michele D. Soleus muscle in glycosylation-deficient muscular dystrophy is protected from contraction-induced injury. Am J Physiol Cell Physiol. 2010;299:C1430-40 pubmed publisher
    ..Interestingly, we show that soleus muscles have a markedly higher sarcolemma expression of ?(1)-containing integrins compared with EDL and gastrocnemius muscles...
  6. Lyon A, MacLeod K, Zhang Y, Garcia E, Kanda G, Lab M, et al. Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci U S A. 2009;106:6854-9 pubmed publisher
    T-tubular invaginations of the sarcolemma of ventricular cardiomyocytes contain junctional structures functionally coupling L-type calcium channels to the sarcoplasmic reticulum calcium-release channels (the ryanodine receptors), and ..
  7. Grubb D, Iliades P, Cooley N, Yu Y, Luo J, Filtz T, et al. Phospholipase Cbeta1b associates with a Shank3 complex at the cardiac sarcolemma. FASEB J. 2011;25:1040-7 pubmed publisher
    ..are mediated exclusively by phospholipase C?1b (PLC?1b), because only this PLC? subtype localizes at the cardiac sarcolemma. In the current study, we investigated the proteins involved in targeting PLC?1b to the sarcolemma in neonatal ..
  8. Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, Aoki M. Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J Neurol Sci. 2010;294:95-101 pubmed publisher
    ..with 100 mM NaCl and barely detected in the pellet fraction, suggesting fragile anchoring of nNOS to the sarcolemma. We also showed an elevated expression of atrogin-1, key molecules in muscle atrophy at the end stage...
  9. Vaughan Jones R, Swietach P. Pushing and pulling the cardiac sodium/hydrogen exchanger. Circ Res. 2008;103:773-5 pubmed publisher
  10. Stefanyk L, Bonen A, Dyck D. Insulin and contraction-induced movement of fatty acid transport proteins to skeletal muscle transverse-tubules is distinctly different than to the sarcolemma. Metabolism. 2012;61:1518-22 pubmed publisher
    Fatty acid (FA) transport proteins are known to exist on the sarcolemma of skeletal muscle. However, it is unknown whether the t-tubules, which comprise ~60% of the cell surface, also harbor these proteins...
  11. Snabaitis A, Cuello F, Avkiran M. Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1. Circ Res. 2008;103:881-90 pubmed publisher
    ..Heterologously expressed myr-PKBalpha was present in the sarcolemma, colocalized with NHE1 at the intercalated disc regions, increased NHE1 phosphorylation, and reduced NHE1 ..
  12. Han R, Kanagawa M, Yoshida Moriguchi T, Rader E, Ng R, Michele D, et al. Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan. Proc Natl Acad Sci U S A. 2009;106:12573-9 pubmed publisher
    Skeletal muscle basal lamina is linked to the sarcolemma through transmembrane receptors, including integrins and dystroglycan...
  13. Kabaeva Z, Meekhof K, Michele D. Sarcolemma instability during mechanical activity in Largemyd cardiac myocytes with loss of dystroglycan extracellular matrix receptor function. Hum Mol Genet. 2011;20:3346-55 pubmed publisher
  14. Head S. Branched fibres in old dystrophic mdx muscle are associated with mechanical weakening of the sarcolemma, abnormal Ca2+ transients and a breakdown of Ca2+ homeostasis during fatigue. Exp Physiol. 2010;95:641-56 pubmed publisher
    ..In particular, any therapy aimed at rescuing the defective gene will presumably have to do so before the number of branched fibres has increased to a level where the muscle is mechanically compromised...
  15. Chase A, Orchard C. Ca efflux via the sarcolemmal Ca ATPase occurs only in the t-tubules of rat ventricular myocytes. J Mol Cell Cardiol. 2011;50:187-93 pubmed publisher
    ..This may be important in heart disease, in which changes in t-tubule structure and protein phosphorylation occur...
  16. Ayalon G, Davis J, Scotland P, Bennett V. An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. Cell. 2008;135:1189-200 pubmed publisher
    ..and the dystrophin-glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma of skeletal muscle...
  17. Lyon A, Nikolaev V, Miragoli M, Sikkel M, Paur H, Benard L, et al. Plasticity of surface structures and ?(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail. 2012;5:357-65 pubmed publisher
    ..Recovery of surface topology is necessary for normalization of ?(2)AR location and signaling responses. ..
  18. Pasek M, Simurda J, Orchard C. Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte. Eur Biophys J. 2012;41:491-503 pubmed publisher
    ..These results provide a deeper understanding of the role of the t-tubules in normal cell function, and are a basis for understanding the changes that occur in heart failure as a result of changes in t-tubule structure and ion fluxes...
  19. Boonen K, Post M. The muscle stem cell niche: regulation of satellite cells during regeneration. Tissue Eng Part B Rev. 2008;14:419-31 pubmed publisher
    ..Understanding more about the control of these satellite cell activities by the niche will facilitate their recruitment and effective deployment for regenerative medicine...
  20. Williamson C, Dabkowski E, Baseler W, Croston T, Alway S, Hollander J. Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location. Am J Physiol Heart Circ Physiol. 2010;298:H633-42 pubmed publisher
    ..These results indicate that diabetes mellitus is associated with an enhanced apoptotic propensity in IFM, suggesting a differential apoptotic susceptibility of distinct mitochondrial subpopulations based upon subcellular location...
  21. Alekseev A, Reyes S, Yamada S, Hodgson Zingman D, Sattiraju S, Zhu Z, et al. Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight. Cell Metab. 2010;11:58-69 pubmed publisher
  22. Ferrantini C, Crocini C, Coppini R, Vanzi F, Tesi C, Cerbai E, et al. The transverse-axial tubular system of cardiomyocytes. Cell Mol Life Sci. 2013;70:4695-710 pubmed publisher
    ..histological feature of striated muscle cells is the presence of deep invaginations of the plasma membrane (sarcolemma), most commonly referred to as T-tubules or the transverse-axial tubular system (TATS)...
  23. James A, Sabirov R, Okada Y. Clustering of protein kinase A-dependent CFTR chloride channels in the sarcolemma of guinea-pig ventricular myocytes. Biochem Biophys Res Commun. 2010;391:841-5 pubmed publisher
    ..These results suggest that CFTR Cl(PKA) channels occur in clusters in the sarcolemma of guinea-pig ventricular myocytes; there was no evidence of a heterogeneous distribution of clusters between ..
  24. Hofer T, Servais S, Seo A, Marzetti E, Hiona A, Upadhyay S, et al. Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mech Ageing Dev. 2009;130:297-307 pubmed publisher
    ..In summary, the age-related reduction of Ca(2+) retention capacity in IFM may explain the increased susceptibility to stress-induced cell death in the aged myocardium...
  25. Dibb K, Clarke J, Horn M, Richards M, Graham H, Eisner D, et al. Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure. Circ Heart Fail. 2009;2:482-9 pubmed publisher
    ..The aims of this study were to determine (i) whether atrial myocytes from a large mammal (sheep) possess t-tubules, (ii) whether these are functionally important, and (iii) whether they are disrupted in heart failure...
  26. Kobayashi Y, Rader E, Crawford R, Iyengar N, Thedens D, Faulkner J, et al. Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature. 2008;456:511-5 pubmed publisher
    ..that this exaggerated fatigue response is distinct from a loss in specific force production by muscle, and that sarcolemma-localized signalling by neuronal nitric oxide synthase (nNOS) in skeletal muscle is required to maintain ..
  27. Murphy R, Mollica J, Lamb G. Plasma membrane removal in rat skeletal muscle fibers reveals caveolin-3 hot-spots at the necks of transverse tubules. Exp Cell Res. 2009;315:1015-28 pubmed publisher
    ..Skeletal muscle fibers present a model where the surface membrane (sarcolemma) can be completely separated from the cell by mechanical dissection...
  28. Alekseev A, Reyes S, Selivanov V, Dzeja P, Terzic A. Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment. J Mol Cell Cardiol. 2012;52:401-9 pubmed publisher
    ..Compared to substrate diffusion in the cytosol, diffusional restrictions underneath the sarcolemma are much larger and could impede ion and nucleotide movement by a factor of 10(3)-10(5)...
  29. Nikolaev V, Moshkov A, Lyon A, Miragoli M, Novak P, Paur H, et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010;327:1653-7 pubmed publisher
    ..Thus, the redistribution of beta(2)ARs in heart failure changes compartmentation of cAMP and might contribute to the failing myocardial phenotype...
  30. Roche J, Lovering R, Bloch R. Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivo. Neuroreport. 2008;19:1579-84 pubmed publisher
    ..Our data indicate that recovery of control muscles from injury primarily involves sarcolemmal repair whereas recovery of dysferlin-null muscles primarily involves myogenesis without repair and long-term survival of myofibers...
  31. Boengler K, Stahlhofen S, van De Sand A, Gres P, Ruiz Meana M, Garcia Dorado D, et al. Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol. 2009;104:141-7 pubmed publisher
    ..Since loss of mitochondrial Cx43 abolishes IP's cardioprotection, SSM and IFM apparently differ in their function in the signal transduction of IP...
  32. Lewis C, Ohlendieck K. Mass spectrometric identification of dystrophin isoform Dp427 by on-membrane digestion of sarcolemma from skeletal muscle. Anal Biochem. 2010;404:197-203 pubmed publisher
    ..of certain target proteins, here we have applied direct on-membrane digestion of one-dimensional blots of the sarcolemma-enriched fraction and the isolated dystrophin-glycoprotein complex...
  33. Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, et al. MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol. 2009;11:56-64 pubmed publisher
  34. Heineke J, Ritter O. Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond. J Mol Cell Cardiol. 2012;52:62-73 pubmed publisher
    ..We review current evidence of subcellular calcineurin mainly at the sarcolemma and the nucleus, but also in association with the sarcoplasmic reticulum and mitochondria...
  35. Crossman D, Ruygrok P, Ruygrok P, Soeller C, Cannell M. Changes in the organization of excitation-contraction coupling structures in failing human heart. PLoS ONE. 2011;6:e17901 pubmed publisher
  36. Bu G, Adams H, Berbari E, Rubart M. Uniform action potential repolarization within the sarcolemma of in situ ventricular cardiomyocytes. Biophys J. 2009;96:2532-46 pubmed publisher
    ..what to our knowledge are the first direct measurements of t-tubule electrical activity in ventricular cardiomyocytes, which support the concept that action potential duration is uniform throughout the sarcolemma of individual cells.
  37. Orchard C, Pásek M, Brette F. The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches. Exp Physiol. 2009;94:509-19 pubmed publisher
    ..This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation-contraction coupling...
  38. Zifarelli G, Pusch M. Relaxing messages from the sarcolemma. J Gen Physiol. 2010;136:593-6 pubmed publisher
  39. Jayasinghe I, Cannell M, Soeller C. Organization of ryanodine receptors, transverse tubules, and sodium-calcium exchanger in rat myocytes. Biophys J. 2009;97:2664-73 pubmed publisher
    ..Distance maps for all colocalization pairs were calculated to give the distance between centroids of punctate labeling and edges for distributed components. The possible roles for punctate NCX labeling are discussed...
  40. Ogneva I. Transversal stiffness of fibers and desmin content in leg muscles of rats under gravitational unloading of various durations. J Appl Physiol (1985). 2010;109:1702-9 pubmed publisher
    The aim of this research was the analysis of structural changes in various parts of the sarcolemma and contractile apparatus of muscle fibers by measuring their transversal stiffness by atomic force microscopy under gravitational ..
  41. Ueda S, Kitazawa S, Ishida K, Nishikawa Y, Matsui M, Matsumoto H, et al. Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J. 2010;24:2254-61 pubmed publisher
    ..translocation of the facilitative glucose transporter GLUT4 from its storage sites to the skeletal muscle sarcolemma depends on Rac1...
  42. Zanou N, Iwata Y, Schakman O, Lebacq J, Wakabayashi S, Gailly P. Essential role of TRPV2 ion channel in the sensitivity of dystrophic muscle to eccentric contractions. FEBS Lett. 2009;583:3600-4 pubmed publisher
    ..This observation points out the role of TRPV2 channel in the physiopathology of Duchenne muscular dystrophy...
  43. Cai C, Weisleder N, Ko J, Komazaki S, Sunada Y, Nishi M, et al. Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. J Biol Chem. 2009;284:15894-902 pubmed publisher
    ..MG53 mediates active trafficking of intracellular vesicles to the sarcolemma and is required for movement of dysferlin to sites of cell injury during repair patch formation...
  44. Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, et al. Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol. 2013;200:523-36 pubmed publisher
  45. de Morrée A, Hensbergen P, van Haagen H, Dragan I, Deelder A, t Hoen P, et al. Proteomic analysis of the dysferlin protein complex unveils its importance for sarcolemmal maintenance and integrity. PLoS ONE. 2010;5:e13854 pubmed publisher
    ..evidence and show dysferlin localization to, and interaction with the focal adhesion protein vinculin at the sarcolemma. Finally, our studies reveal evidence for cross-talk between dysferlin and its protein family member myoferlin...
  46. Arechavala Gomeza V, Kinali M, Feng L, Brown S, Sewry C, Morgan J, et al. Immunohistological intensity measurements as a tool to assess sarcolemma-associated protein expression. Neuropathol Appl Neurobiol. 2010;36:265-74 pubmed publisher
    ..We therefore sought to develop a method to quantify relative levels of sarcolemma-associated proteins using digitally captured images of immunolabelled sections of skeletal muscle.
  47. Jovanović S, Du Q, Sukhodub A, Jovanović A. M-LDH physically associated with sarcolemmal K ATP channels mediates cytoprotection in heart embryonic H9C2 cells. Int J Biochem Cell Biol. 2009;41:2295-301 pubmed publisher
    ..2/SUR2A regulates the activity of sarcolemmal K(ATP) channels as well as an intracellular ATP production during metabolic stress, both of which are important for cell survival. ..
  48. Hijikata T, Nakamura A, Isokawa K, Imamura M, Yuasa K, Ishikawa R, et al. Plectin 1 links intermediate filaments to costameric sarcolemma through beta-synemin, alpha-dystrobrevin and actin. J Cell Sci. 2008;121:2062-74 pubmed publisher
    In skeletal muscles, the sarcolemma is possibly stabilized and protected against contraction-imposed stress by intermediate filaments (IFs) tethered to costameric sarcolemma...
  49. Zhang Y, Duan D. Novel mini-dystrophin gene dual adeno-associated virus vectors restore neuronal nitric oxide synthase expression at the sarcolemma. Hum Gene Ther. 2012;23:98-103 pubmed publisher
    ..Localization of nNOS to the sarcolemma may greatly improve the therapeutic outcome in DMD (Lai, Y., Thomas, G.D., Yue, Y., et al. [2009]. J. Clin...
  50. Peter A, Ko C, Kim M, Hsu N, Ouchi N, Rhie S, et al. Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet. 2009;18:318-27 pubmed publisher
    Duchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting...
  51. Desaphy J, Pierno S, Liantonio A, Giannuzzi V, Digennaro C, Dinardo M, et al. Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles. Pharmacol Res. 2010;61:553-63 pubmed publisher
    ..In parallel, HU Sol displayed an increased sarcolemma chloride conductance related to an increased expression of ClC-1 channels, changes in excitability parameters, a ..
  52. Klinge L, Harris J, Sewry C, Charlton R, Anderson L, Laval S, et al. Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle. Muscle Nerve. 2010;41:166-73 pubmed publisher
    ..Dysferlin mainly localizes to the sarcolemma in mature skeletal muscle where it is implicated in membrane fusion and repair...
  53. Häger M, Bigotti M, Meszaros R, Carmignac V, Holmberg J, Allamand V, et al. Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. J Biol Chem. 2008;283:24760-9 pubmed publisher
    ..In skeletal muscle, Cib2 colocalizes with the integrin alpha7B subunit at the sarcolemma and at the neuromuscular and myotendinous junctions...
  54. Percival J, Anderson K, Gregorevic P, Chamberlain J, Froehner S. Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice. PLoS ONE. 2008;3:e3387 pubmed publisher
    Skeletal muscle nNOSmu (neuronal nitric oxide synthase mu) localizes to the sarcolemma through interaction with the dystrophin-associated glycoprotein (DAG) complex, where it synthesizes nitric oxide (NO)...
  55. Jovanovic A, Jovanovic S. SURA2 targeting for cardioprotection?. Curr Opin Pharmacol. 2009;9:189-93 pubmed publisher
  56. Sabourin J, Lamiche C, Vandebrouck A, Magaud C, Rivet J, Cognard C, et al. Regulation of TRPC1 and TRPC4 cation channels requires an alpha1-syntrophin-dependent complex in skeletal mouse myotubes. J Biol Chem. 2009;284:36248-61 pubmed publisher
    ..TRPC1 and TRPC4 channels are expressed at the sarcolemma of muscle cells; forced expression or siRNA silencing showed that cation influx regulated by alpha1-syntrophin ..
  57. Lai Y, Thomas G, Yue Y, Yang H, Li D, Long C, et al. Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy. J Clin Invest. 2009;119:624-35 pubmed publisher
    b>Sarcolemma-associated neuronal NOS (nNOS) plays a critical role in normal muscle physiology...
  58. Li J, Kline C, Hund T, Anderson M, Mohler P. Ankyrin-B regulates Kir6.2 membrane expression and function in heart. J Biol Chem. 2010;285:28723-30 pubmed publisher
    ..Collectively, our new findings define a new role for cardiac ankyrin polypeptides in regulation of ion channel membrane expression in heart...
  59. Costa A, Orosz Z, Apor P, Nyakas C, Siamilis S, Csende Z, et al. Impact of repeated bouts of eccentric exercise on sarcolemma disruption in human skeletal muscle. Acta Physiol Hung. 2009;96:189-202 pubmed publisher
    In animal models, unaccustomed eccentric exercise (EE) has been widely related to muscle fiber membrane (sarcolemma) damage...
  60. Lueck J, Rossi A, Thornton C, Campbell K, Dirksen R. Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle. J Gen Physiol. 2010;136:597-613 pubmed publisher
    ..and confocal microscopy, native ClC-1 channels in adult mouse FDB fibers were localized within the sarcolemma, 90 degrees out of phase with double rows of dihydropyridine receptor immunostaining of the T-tubule system...