pseudopodia

Summary

Summary: A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.

Top Publications

  1. Tsygankov D, Bilancia C, Vitriol E, Hahn K, Peifer M, Elston T. CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. J Cell Biol. 2014;204:443-60 pubmed publisher
  2. Goh W, Lim K, Sudhaharan T, Sem K, Bu W, Chou A, et al. mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation. J Biol Chem. 2012;287:4702-14 pubmed publisher
    ..These findings suggest that mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia...
  3. Coutinho Budd J, Ghukasyan V, Zylka M, Polleux F. The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently. J Cell Sci. 2012;125:3390-401 pubmed publisher
    ..Overall, our results provide novel insights into the functional diversity of the membrane deformation properties of this subclass of F-BAR-domains required for cell morphogenesis...
  4. Crespi A, Ferrari I, Lonati P, Disanza A, Fornasari D, Scita G, et al. LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53. J Cell Sci. 2012;125:4543-54 pubmed publisher
    ..Collectively these data indicate that LIN7 is a novel regulator of IRSp53, and that the association of these proteins is required to promote the formation of actin-dependent filopodia and neurites...
  5. Gradilla A, Guerrero I. Cytoneme-mediated cell-to-cell signaling during development. Cell Tissue Res. 2013;352:59-66 pubmed publisher
    ..The processes that initiate and regulate the formation, orientation and dynamics of cytonemes are poorly understood but are potentially extremely important areas for our knowledge of intercellular communication...
  6. Kerstein P, Jacques Fricke B, Rengifo J, Mogen B, Williams J, Gottlieb P, et al. Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci. 2013;33:273-85 pubmed publisher
    ..Together our results suggest that Ca(2+) influx through MS TRPC1 on filopodia activates calpain to control growth cone turning during development...
  7. Kornberg T, Roy S. Cytonemes as specialized signaling filopodia. Development. 2014;141:729-36 pubmed publisher
    ..This evidence suggests that cytoneme-mediated signaling is a dispersal mechanism that delivers signaling proteins directly at sites of cell-cell contact. ..
  8. Ura S, Pollitt A, Veltman D, Morrice N, Machesky L, Insall R. Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Curr Biol. 2012;22:553-61 pubmed publisher
    ..SCAR/WAVE is phosphorylated at multiple sites, but how this affects its biological activity is unclear. Here we show that dephosphorylation of Dictyostelium SCAR controls normal pseudopod dynamics...
  9. Hagedorn E, Ziel J, Morrissey M, Linden L, Wang Z, Chi Q, et al. The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. J Cell Biol. 2013;201:903-13 pubmed publisher
    ..These studies reveal an UNC-40-mediated morphogenetic transition at the cell-basement membrane interface that directs invading cells across basement membrane barriers...

More Information

Publications76

  1. Cardone R, Greco M, Capulli M, Weinman E, Busco G, Bellizzi A, et al. NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Mol Biol Cell. 2012;23:2028-40 pubmed publisher
  2. Petrie R, Gavara N, Chadwick R, Yamada K. Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol. 2012;197:439-55 pubmed publisher
    ..Thus, the relative polarization of intracellular signaling identifies two distinct modes of 3D cell migration governed intrinsically by RhoA, ROCK, and myosin II and extrinsically by the elastic behavior of the 3D extracellular matrix...
  3. Willmer T, Contu L, Blatch G, Edkins A. Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines. Cancer Lett. 2013;328:252-60 pubmed publisher
    ..Hop was identified in isolated pseudopodia fractions; it colocalised with actin in lamellipodia, and co-sedimented with purified actin in vitro...
  4. Endris V, Haussmann L, Buss E, Bacon C, Bartsch D, Rappold G. SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions. J Cell Sci. 2011;124:3941-55 pubmed publisher
    ..Furthermore, we show that mouse embryonic fibroblasts derived from homozygous srGAP3-knockout embryos display an increased cell area and lamellipodia formation that can be blocked by shRNA-mediated knockdown of lamellipodin...
  5. Veltman D, King J, Machesky L, Insall R. SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods. J Cell Biol. 2012;198:501-8 pubmed publisher
    ..We conclude that WASP and SCAR can regulate pseudopod actin using similar mechanisms...
  6. Zhao J, Bruck S, Cemerski S, Zhang L, Butler B, Dani A, et al. CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia. Mol Cell Biol. 2013;33:38-47 pubmed publisher
    ..Our data demonstrate how the interplay between specialized actin regulatory molecules shapes the actin cytoskeleton...
  7. Roy S, Huang H, Liu S, Kornberg T. Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein. Science. 2014;343:1244624 pubmed publisher
  8. Gandy K, Canals D, Adada M, Wada M, Roddy P, Snider A, et al. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013;449:661-72 pubmed publisher
    ..Taken together, the results demonstrate a novel mechanism by which S1P regulates cellular architecture that requires S1PR2 and subsequent phosphorylation of ERM proteins...
  9. Yamamoto K, Murata H, Putranto E, Kataoka K, Motoyama A, Hibino T, et al. DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells. Oncol Rep. 2013;29:1073-9 pubmed publisher
    ..in the formation of abundant highly branched filopodia-like protrusions, dendritic pseudopodia. Blocking of the function of DOCK7 greatly abrogated the formation of dendritic pseudopodia and ..
  10. Sanders T, Llagostera E, Barna M. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature. 2013;497:628-32 pubmed publisher
    ..Together, these studies identify an important mode of communication between cells that considerably extends our understanding of ligand movement and reception during vertebrate tissue patterning...
  11. Bornschlögl T, Romero S, Vestergaard C, Joanny J, Van Nhieu G, Bassereau P. Filopodial retraction force is generated by cortical actin dynamics and controlled by reversible tethering at the tip. Proc Natl Acad Sci U S A. 2013;110:18928-33 pubmed publisher
    ..Transient reconnection at the tip allows filopodia to continuously probe their surroundings in a load-and-fail manner within a well-defined force range. ..
  12. Houk A, Jilkine A, Mejean C, Boltyanskiy R, Dufresne E, Angenent S, et al. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012;148:175-88 pubmed publisher
  13. Klemke R. Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits. Curr Opin Cell Biol. 2012;24:662-9 pubmed publisher
    Metastatic cancer cells produce invasive membrane protrusions called invadopodia and pseudopodia, which play a central role in driving cancer cell dissemination in the body...
  14. Seiler C, Davuluri G, Abrams J, Byfield F, Janmey P, Pack M. Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol. 2012;10:e1001386 pubmed publisher
    ..In addition, they identify an inducible physical signaling pathway sensitive to redox and oncogenic signaling that can drive this process...
  15. Nishimura Y, Applegate K, Davidson M, Danuser G, Waterman C. Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells. PLoS ONE. 2012;7:e41413 pubmed publisher
    ..Thus, automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration...
  16. Bergert M, Chandradoss S, Desai R, Paluch E. Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A. 2012;109:14434-9 pubmed publisher
  17. Wu C, Asokan S, Berginski M, Haynes E, Sharpless N, Griffith J, et al. Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell. 2012;148:973-87 pubmed publisher
    ..Consistent with this finding, cells depleted of Arp2/3 fail to globally align focal adhesions, suggesting that one principle function of lamellipodia is to organize cell-matrix adhesions in a spatially coherent manner...
  18. van Rijssel J, Hoogenboezem M, Wester L, Hordijk P, van Buul J. The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS ONE. 2012;7:e29912 pubmed publisher
    ..Together, we conclude that the GEF Trio is responsible for lamellipodia formation through its N-terminal DH-PH domain in a Rac1-dependent manner during fibronectin-mediated spreading and migration...
  19. Dun X, Bandeira de Lima T, Allen J, Geraldo S, Gordon Weeks P, Chilton J. Drebrin controls neuronal migration through the formation and alignment of the leading process. Mol Cell Neurosci. 2012;49:341-50 pubmed publisher
    ..Furthermore, we have shown that the actions of drebrin can be segregated within individual motor neurons to direct their migration independently of axon guidance...
  20. Kelsey J, Fastman N, Blumberg D. Evidence of an evolutionarily conserved LMBR1 domain-containing protein that associates with endocytic cups and plays a role in cell migration in dictyostelium discoideum. Eukaryot Cell. 2012;11:401-16 pubmed publisher
    ..We provide evidence of an LMBR1 family plasma membrane protein that associates with endocytic cups and plays a role in chemotaxis...
  21. Vinzenz M, Nemethova M, Schur F, Mueller J, Narita A, Urban E, et al. Actin branching in the initiation and maintenance of lamellipodia. J Cell Sci. 2012;125:2775-85 pubmed publisher
    ..A possible role of filament capping in generating the lamellipodium leaflet is discussed and a mathematical model of protrusion is also presented...
  22. Suraneni P, Rubinstein B, Unruh J, Durnin M, Hanein D, Li R. The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration. J Cell Biol. 2012;197:239-51 pubmed publisher
    ..These results provide insights into the Arp2/3 complex's critical role in lamellipodia extension and directional fibroblast migration...
  23. Lee C, Vitriol E, Shim S, Wise A, Velayutham R, Zheng J. Dynamic localization of G-actin during membrane protrusion in neuronal motility. Curr Biol. 2013;23:1046-56 pubmed publisher
    ..Monomeric globular actin (G-actin) is the building block for F-actin but is not considered to play a direct role in spatiotemporal control of actin dynamics in cell motility...
  24. Albuschies J, Vogel V. The role of filopodia in the recognition of nanotopographies. Sci Rep. 2013;3:1658 pubmed publisher
    ..Filopodia thus play a central role in steering transient topographic preferences...
  25. Kawabata I, Kashiwagi Y, Obashi K, Ohkura M, Nakai J, Wynshaw Boris A, et al. LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites. Nat Commun. 2012;3:722 pubmed publisher
    ..Taken together, these findings suggest the existence of an active microtubule-dependent mechanism for synaptic translocation that helps in the establishment of proper synaptic distribution on dendrites...
  26. Hamill K, Hopkinson S, Skalli O, Jones J. Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions. FASEB J. 2013;27:546-56 pubmed publisher
    ..Together, our data indicate a role for actinin-4 in regulating the steering mechanism of keratinocytes via profound effects on their matrix adhesion sites...
  27. Nicol X, Hong K, Spitzer N. Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A. 2011;108:13776-81 pubmed publisher
    ..We show that filopodial cAMP transients regulate spinal axon guidance in vitro and commissural axon pathfinding in vivo. These growth cone codes provide a basis for selective activation of specific downstream effectors. ..
  28. Arstikaitis P, Gauthier Campbell C, Huang K, El Husseini A, Murphy T. Proteins that promote filopodia stability, but not number, lead to more axonal-dendritic contacts. PLoS ONE. 2011;6:e16998 pubmed publisher
    ..Taken together, these results suggest that increased filopodia stability and not density, may be the rate-limiting step for synapse formation. ..
  29. Cohen M, Baum B, Miodownik M. The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling. J R Soc Interface. 2011;8:787-98 pubmed publisher
    ..Thus, intermittent protrusion-based signalling has the potential to yield robust self-organizing tissue-wide patterns without the need to invoke diffusion-mediated signalling. ..
  30. Boehm B, Westerberg H, Lesnicar Pucko G, Raja S, Rautschka M, Cotterell J, et al. The role of spatially controlled cell proliferation in limb bud morphogenesis. PLoS Biol. 2010;8:e1000420 pubmed publisher
    ..We therefore provide both theoretical and empirical evidence that limb bud elongation is achieved by directional cell activities, rather than a PD gradient of proliferation rates. ..
  31. Demarco R, Lundquist E. RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration. PLoS Genet. 2010;6:e1001215 pubmed publisher
  32. Diz Muñoz A, Krieg M, Bergert M, Ibarlucea Benitez I, Muller D, Paluch E, et al. Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol. 2010;8:e1000544 pubmed publisher
    ..We propose that MCA is a key parameter controlling the relative proportions of different cell protrusion types in mesendoderm progenitors, and thus is key in controlling directed migration during gastrulation. ..
  33. Lin L, McCroskery S, Ross J, Chak Y, Neuhuber B, Daniels M. Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases. Exp Cell Res. 2010;316:2260-77 pubmed publisher
    ..Our results suggest that TM-agrin regulates actin-based protrusions in large part through interaction of its GAG chains with extracellular or transmembrane proteins, leading to the activation of Cdc42 and Rac1. ..
  34. Chen S, Tari P, She K, Haas K. Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Neuron. 2010;67:967-83 pubmed publisher
  35. Ridley A. Life at the leading edge. Cell. 2011;145:1012-22 pubmed publisher
    ..In addition, these different protrusion methods likely act in concert to move cells through complex environments in vivo. ..
  36. Kabaso D, Shlomovitz R, Schloen K, Stradal T, Gov N. Theoretical model for cellular shapes driven by protrusive and adhesive forces. PLoS Comput Biol. 2011;7:e1001127 pubmed publisher
    ..This result can provide an explanation for a number of puzzling experimental observations regarding cellular shape dependence on the properties of the extra-cellular matrix. ..
  37. Liebau S, Steinestel J, Linta L, Kleger A, Storch A, Schoen M, et al. An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis. PLoS ONE. 2011;6:e18148 pubmed publisher
  38. Isaac B, Ishihara D, Nusblat L, Gevrey J, Dovas A, Condeelis J, et al. N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis. Exp Cell Res. 2010;316:3406-16 pubmed publisher
    ..Our study suggests that expression levels of WASP and N-WASP may influence their roles in actin cytoskeleton rearrangement and shed light to the complex intertwining roles WASP and N-WASP play in macrophages. ..
  39. Lányi Ã, Baráth M, Péterfi Z, Bogel G, Orient A, Simon T, et al. The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS ONE. 2011;6:e23653 pubmed publisher
    ..Because SH3PXD2B also forms a complex with the C-terminal region of cortactin, we propose that SH3PXD2B is a scaffold protein that plays a key role in regulating the actin cytoskeleton via Src and cortactin. ..
  40. Goh W, Sudhaharan T, Lim K, Sem K, Lau C, Ahmed S. Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors. J Biol Chem. 2011;286:13681-94 pubmed publisher
    ..Taken together, these results suggest a novel pathway for filopodia formation via Rif and mDia1. ..
  41. Fanti Z, Martinez Perez M, De Miguel F. NeuronGrowth, a software for automatic quantification of neurite and filopodial dynamics from time-lapse sequences of digital images. Dev Neurobiol. 2011;71:870-81 pubmed publisher
    ..ifc.unam.mx or http://www.ifc.unam.mx/ffm/index.html...
  42. Shafer B, Onishi K, Lo C, Colakoglu G, Zou Y. Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance. Dev Cell. 2011;20:177-91 pubmed publisher
  43. Sawamiphak S, Seidel S, Essmann C, Wilkinson G, Pitulescu M, Acker T, et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature. 2010;465:487-91 pubmed publisher
    ..Blocking ephrin-B2 reverse signalling may be an attractive alternative or combinatorial anti-angiogenic therapy strategy to disrupt VEGFR2 function in tumour angiogenesis...
  44. Plantard L, Arjonen A, Lock J, Nurani G, Ivaska J, Stromblad S. PtdIns(3,4,5)P? is a regulator of myosin-X localization and filopodia formation. J Cell Sci. 2010;123:3525-34 pubmed publisher
  45. Morimura S, Suzuki K, Takahashi K. Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate. Biochem Biophys Res Commun. 2011;404:834-40 pubmed publisher
  46. Stratman A, Davis M, Davis G. VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines. Blood. 2011;117:3709-19 pubmed publisher
  47. Scorticati C, Formoso K, Frasch A. Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts. J Neurochem. 2011;119:521-31 pubmed publisher
    ..Taken together, our findings reveal that the association of M6a with lipid rafts is important for its role in filopodia formation and Src and MAPK kinases participate in M6a signal propagation...
  48. Jansen S, Collins A, Yang C, Rebowski G, Svitkina T, Dominguez R. Mechanism of actin filament bundling by fascin. J Biol Chem. 2011;286:30087-96 pubmed publisher
    ..These molecules could guide the rational design of new anticancer fascin inhibitors...
  49. Mura M, Swain R, Zhuang X, Vorschmitt H, Reynolds G, Durant S, et al. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene. 2012;31:293-305 pubmed publisher
  50. Sun J, He H, Xiong Y, Lu S, Shen J, Cheng A, et al. Fascin protein is critical for transforming growth factor ? protein-induced invasion and filopodia formation in spindle-shaped tumor cells. J Biol Chem. 2011;286:38865-75 pubmed publisher
    ..Our data also suggest that fascin could play a central role in TGF?-promoted tumor metastasis...
  51. Kerber M, Cheney R. Myosin-X: a MyTH-FERM myosin at the tips of filopodia. J Cell Sci. 2011;124:3733-41 pubmed publisher
    ..At the cellular and organismal level, growing evidence demonstrates that Myo10 has crucial functions in numerous processes ranging from invadopodia formation to cell migration...
  52. Lee K, Gallop J, Rambani K, Kirschner M. Self-assembly of filopodia-like structures on supported lipid bilayers. Science. 2010;329:1341-5 pubmed publisher
    ..We propose that filopodia form via clustering of Arp2/3 complex activators, self-assembly of filopodial tip complexes on the membrane, and outgrowth of actin bundles...
  53. Baumgartner M. Theileria annulata promotes Src kinase-dependent host cell polarization by manipulating actin dynamics in podosomes and lamellipodia. Cell Microbiol. 2011;13:538-53 pubmed publisher
    ..These findings suggest that T. annulata equips its host cell with properties to adhere and invade. These properties are likely to promote the motile behaviour required for dissemination of infected cells in vivo...
  54. Li A, Ma Y, Yu X, Mort R, Lindsay C, Stevenson D, et al. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell. 2011;21:722-34 pubmed publisher
    ..Myosin contractility balances the extension of long pseudopods by effecting retraction and allowing force generation for movement through the complex 3D epidermal environment...
  55. Oser M, Mader C, Gil Henn H, Magalhaes M, Bravo Cordero J, Koleske A, et al. Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci. 2010;123:3662-73 pubmed publisher
  56. Burnette D, Manley S, Sengupta P, Sougrat R, Davidson M, Kachar B, et al. A role for actin arcs in the leading-edge advance of migrating cells. Nat Cell Biol. 2011;13:371-81 pubmed publisher
    ..The actin arc thereby serves as a structural element underlying the temporal and spatial connection between the lamellipodium and the lamella during directed cell motion. ..
  57. Lu Q, Yu J, Yan J, Wei Z, Zhang M. Structural basis of the myosin X PH1(N)-PH2-PH1(C) tandem as a specific and acute cellular PI(3,4,5)P(3) sensor. Mol Biol Cell. 2011;22:4268-78 pubmed publisher
    ..Finally, we demonstrate that disruption of PH2-mediated binding to PI(3,4,5)P(3) abolishes MyoX's function in inducing filopodial formation and elongation...
  58. Ketschek A, Gallo G. Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia. J Neurosci. 2010;30:12185-97 pubmed publisher
  59. Harris E, Gauvin T, Heimsath E, Higgs H. Assembly of filopodia by the formin FRL2 (FMNL3). Cytoskeleton (Hoboken). 2010;67:755-72 pubmed publisher
    ..The data suggest that the FH2 domain of FRL2 possesses properties not shared by FRL1 that allow it to generate filopodia...
  60. Husainy A, Morrow A, Perkins T, Lee J. Robust patterns in the stochastic organization of filopodia. BMC Cell Biol. 2010;11:86 pubmed publisher
    ..Neither is it clear how quantitatively robust the cellular filopodial network is and how perturbations alter it...
  61. Norris A, Lundquist E. UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans. Development. 2011;138:4433-42 pubmed publisher
    ..g. filopodial) protrusion...
  62. Mader C, Oser M, Magalhaes M, Bravo Cordero J, Condeelis J, Koleske A, et al. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res. 2011;71:1730-41 pubmed publisher
    ..Furthermore, they identify Arg as a novel mediator of invadopodia function and a candidate therapeutic target to inhibit tumor invasion in vivo...
  63. Aerbajinai W, Liu L, Chin K, Zhu J, Parent C, Rodgers G. Glia maturation factor-? mediates neutrophil chemotaxis. J Leukoc Biol. 2011;90:529-38 pubmed publisher
    ..In addition, we found that GMFG is associated with WAVE2. Taken together, our findings suggest that GMFG is a novel factor in regulating neutrophil chemotaxis by modulating actin cytoskeleton reorganization...
  64. Kelley L, Ammer A, Hayes K, Martin K, Machida K, Jia L, et al. Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. J Cell Sci. 2010;123:3923-32 pubmed publisher
    ..Our findings describe a previously unappreciated role for proto-oncogenic Src in enabling the invasive activity of constitutively active Src alleles...
  65. Small J. Dicing with dogma: de-branching the lamellipodium. Trends Cell Biol. 2010;20:628-33 pubmed publisher
    ..These findings signal a reconsideration of the structural basis of protrusion and about the roles of the different actin nucleating and elongating complexes involved in the process...
  66. Cohen M, Georgiou M, Stevenson N, Miodownik M, Baum B. Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell. 2010;19:78-89 pubmed publisher
    ..Significantly, the intermittent signaling induced by these filopodial dynamics generates a type of structured noise that is uniquely suited to the generation of well-ordered, tissue-wide epithelial patterns...
  67. Huang K, Chen G, Cheng C, Liao K, Hung C, Chang G, et al. Phosphorylation of the zebrafish M6Ab at serine 263 contributes to filopodium formation in PC12 cells and neurite outgrowth in zebrafish embryos. PLoS ONE. 2011;6:e26461 pubmed publisher
    ..In the present study, we used the zebrafish as a model system to investigate the role of zebrafish M6Ab in filopodium formation in PC12 cells and neurite outgrowth in zebrafish embryos...