nuclear pore

Summary

Summary: An opening through the NUCLEAR ENVELOPE formed by the nuclear pore complex which transports nuclear proteins or RNA into or out of the CELL NUCLEUS and which, under some conditions, acts as an ion channel.

Top Publications

  1. Li Z, Zhu Y, Zhai Y, R Castroagudin M, Bao Y, White T, et al. Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1. Biochim Biophys Acta. 2013;1833:3338-3345 pubmed publisher
    ..Our data suggest the link of the NDC1 and WRN as one facet of the network between the nuclear periphery and genome stability. Loss of WRN complex leads to multiple alterations at the NPC and the nucleolus. ..
  2. Noble K, Tran E, Alcázar Román A, Hodge C, Cole C, Wente S. The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1. Genes Dev. 2011;25:1065-77 pubmed publisher
    Essential messenger RNA (mRNA) export factors execute critical steps to mediate directional transport through nuclear pore complexes (NPCs)...
  3. Grossman E, Medalia O, Zwerger M. Functional architecture of the nuclear pore complex. Annu Rev Biophys. 2012;41:557-84 pubmed publisher
    The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm...
  4. Flemming D, Sarges P, Stelter P, Hellwig A, Bottcher B, Hurt E. Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores. J Cell Biol. 2009;185:387-95 pubmed publisher
    How individual nucleoporins (Nups) perform their role in nuclear pore structure and function is largely unknown. In this study, we examined the structure of purified Nup170 to obtain clues about its function...
  5. Lau C, Delmar V, Chan R, Phung Q, Bernis C, Fichtman B, et al. Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell. 2009;20:4043-58 pubmed publisher
    ..Nuclear assembly itself requires the precise formation of both nuclear membranes and nuclear pore complexes...
  6. Abaitua F, Hollinshead M, Bolstad M, Crump C, O Hare P. A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore. J Virol. 2012;86:8998-9014 pubmed publisher
    To initiate infection, herpesviruses must navigate to and transport their genomes across the nuclear pore. VP1-2 is a large structural protein of the virion that is conserved in all herpesviruses and plays multiple essential roles in ..
  7. Romes E, Tripathy A, Slep K. Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction. J Biol Chem. 2012;287:15862-73 pubmed publisher
    The nuclear pore complex gates nucleocytoplasmic transport through a massive, eight-fold symmetric channel capped by a nucleoplasmic basket and structurally unique, cytoplasmic fibrils whose tentacles bind and regulate asymmetric traffic...
  8. GRUNWALD D, Singer R. In vivo imaging of labelled endogenous ?-actin mRNA during nucleocytoplasmic transport. Nature. 2010;467:604-7 pubmed publisher
    ..There is extensive knowledge on the physical structure and composition of the nuclear pore complex, but transport selectivity and the dynamics of mRNA export at nuclear pores remain unknown...
  9. Adams R, Wente S. Uncovering nuclear pore complexity with innovation. Cell. 2013;152:1218-21 pubmed publisher
    Advances in imaging and reductionist approaches have provided a high-resolution understanding of nuclear pore complex structure and transport, revealing unexpected mechanistic complexities based on nucleoporin functions and specialized ..
  10. Doucet C, Talamas J, Hetzer M. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 2010;141:1030-41 pubmed publisher
    In metazoa, nuclear pore complexes (NPCs) assemble from disassembled precursors into a reforming nuclear envelope (NE) at the end of mitosis and into growing intact NEs during interphase...

Detail Information

Publications62

  1. Li Z, Zhu Y, Zhai Y, R Castroagudin M, Bao Y, White T, et al. Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1. Biochim Biophys Acta. 2013;1833:3338-3345 pubmed publisher
    ..Our data suggest the link of the NDC1 and WRN as one facet of the network between the nuclear periphery and genome stability. Loss of WRN complex leads to multiple alterations at the NPC and the nucleolus. ..
  2. Noble K, Tran E, Alcázar Román A, Hodge C, Cole C, Wente S. The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1. Genes Dev. 2011;25:1065-77 pubmed publisher
    Essential messenger RNA (mRNA) export factors execute critical steps to mediate directional transport through nuclear pore complexes (NPCs)...
  3. Grossman E, Medalia O, Zwerger M. Functional architecture of the nuclear pore complex. Annu Rev Biophys. 2012;41:557-84 pubmed publisher
    The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm...
  4. Flemming D, Sarges P, Stelter P, Hellwig A, Bottcher B, Hurt E. Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores. J Cell Biol. 2009;185:387-95 pubmed publisher
    How individual nucleoporins (Nups) perform their role in nuclear pore structure and function is largely unknown. In this study, we examined the structure of purified Nup170 to obtain clues about its function...
  5. Lau C, Delmar V, Chan R, Phung Q, Bernis C, Fichtman B, et al. Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell. 2009;20:4043-58 pubmed publisher
    ..Nuclear assembly itself requires the precise formation of both nuclear membranes and nuclear pore complexes...
  6. Abaitua F, Hollinshead M, Bolstad M, Crump C, O Hare P. A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore. J Virol. 2012;86:8998-9014 pubmed publisher
    To initiate infection, herpesviruses must navigate to and transport their genomes across the nuclear pore. VP1-2 is a large structural protein of the virion that is conserved in all herpesviruses and plays multiple essential roles in ..
  7. Romes E, Tripathy A, Slep K. Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction. J Biol Chem. 2012;287:15862-73 pubmed publisher
    The nuclear pore complex gates nucleocytoplasmic transport through a massive, eight-fold symmetric channel capped by a nucleoplasmic basket and structurally unique, cytoplasmic fibrils whose tentacles bind and regulate asymmetric traffic...
  8. GRUNWALD D, Singer R. In vivo imaging of labelled endogenous ?-actin mRNA during nucleocytoplasmic transport. Nature. 2010;467:604-7 pubmed publisher
    ..There is extensive knowledge on the physical structure and composition of the nuclear pore complex, but transport selectivity and the dynamics of mRNA export at nuclear pores remain unknown...
  9. Adams R, Wente S. Uncovering nuclear pore complexity with innovation. Cell. 2013;152:1218-21 pubmed publisher
    Advances in imaging and reductionist approaches have provided a high-resolution understanding of nuclear pore complex structure and transport, revealing unexpected mechanistic complexities based on nucleoporin functions and specialized ..
  10. Doucet C, Talamas J, Hetzer M. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 2010;141:1030-41 pubmed publisher
    In metazoa, nuclear pore complexes (NPCs) assemble from disassembled precursors into a reforming nuclear envelope (NE) at the end of mitosis and into growing intact NEs during interphase...
  11. Iino H, Maeshima K, Nakatomi R, Kose S, Hashikawa T, Tachibana T, et al. Live imaging system for visualizing nuclear pore complex (NPC) formation during interphase in mammalian cells. Genes Cells. 2010;15:647-60 pubmed publisher
    b>Nuclear pore complexes (NPCs) are 'supramolecular complexes' on the nuclear envelope assembled from multiple copies of approximately 30 different proteins called nucleoporins (Nups) that provide aqueous channels for nucleocytoplasmic ..
  12. Bano D, Dinsdale D, Cabrera Socorro A, Maida S, Lambacher N, McColl B, et al. Alteration of the nuclear pore complex in Ca(2+)-mediated cell death. Cell Death Differ. 2010;17:119-33 pubmed publisher
    ..characterized, only a handful of studies have examined the functional and structural alterations of the nuclear pore complex (NPC) during neuronal death...
  13. L schberger A, van de Linde S, Dabauvalle M, Rieger B, Heilemann M, Krohne G, et al. Super-resolution imaging visualizes the eightfold symmetry of gp210 proteins around the nuclear pore complex and resolves the central channel with nanometer resolution. J Cell Sci. 2012;125:570-5 pubmed publisher
    One of the most complex molecular machines of cells is the nuclear pore complex (NPC), which controls all trafficking of molecules in and out of the nucleus...
  14. Whittle J, Schwartz T. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. J Biol Chem. 2009;284:28442-52 pubmed publisher
    The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the eukaryotic cell and forms the exclusive gateway to the nucleus...
  15. Leksa N, Schwartz T. Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats: commonalities, differences, challenges. Nucleus. 2010;1:314-8 pubmed publisher
    The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ?30 nucleoporins (nups)...
  16. Rajanala K, Nandicoori V. Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA. PLoS ONE. 2012;7:e29921 pubmed publisher
    Nucleoporin Tpr is a component of the nuclear pore complex (NPC) that localizes exclusively to intranuclear filaments...
  17. Prodon F, Hanawa K, Nishida H. Actin microfilaments guide the polarized transport of nuclear pore complexes and the cytoplasmic dispersal of Vasa mRNA during GVBD in the ascidian Halocynthia roretzi. Dev Biol. 2009;330:377-88 pubmed publisher
    ..Interestingly, the nuclear pore complex protein Nup153 accumulates at the vegetal tip of actin bundles...
  18. Hackmann A, Gross T, Baierlein C, Krebber H. The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits. EMBO Rep. 2011;12:1024-31 pubmed publisher
    ..Npl3 interacts with the 25S rRNA, ribosomal and ribosome-associated proteins, as well as with the nuclear pore complex...
  19. Herrmann M, Neuberth N, Wissler J, Perez J, Gradl D, Naber A. Near-field optical study of protein transport kinetics at a single nuclear pore. Nano Lett. 2009;9:3330-6 pubmed publisher
    The kinetics of proteins passing through individual nuclear pore complexes (NPCs) of the nuclear envelope (NE) was studied using near-field scanning optical microscopy (NSOM) in combination with fluorescence correlation spectroscopy (FCS)...
  20. Roerink S, Koole W, Stapel L, Romeijn R, Tijsterman M. A broad requirement for TLS polymerases ? and ?, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. PLoS Genet. 2012;8:e1002800 pubmed publisher
    ..Our data suggest SUMO-mediated regulation of both POLH-1 and POLK-1, and point towards a previously unrecognized role of the nuclear pore in regulating TLS.
  21. Fiserova J, Goldberg M. Relationships at the nuclear envelope: lamins and nuclear pore complexes in animals and plants. Biochem Soc Trans. 2010;38:829-31 pubmed publisher
    ..Primarily, this is by nucleocytoplasmic trafficking facilitated by NPCs (nuclear pore complexes)...
  22. Theerthagiri G, Eisenhardt N, Schwarz H, Antonin W. The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. J Cell Biol. 2010;189:1129-42 pubmed publisher
    All transport across the nuclear envelope (NE) is mediated by nuclear pore complexes (NPCs)...
  23. Rexach M. Piecing together nuclear pore complex assembly during interphase. J Cell Biol. 2009;185:377-9 pubmed publisher
    All nucleocytoplasmic traffic of macromolecules occurs through nuclear pore complexes (NPCs), which function as stents in the nuclear envelope to keep nuclear pores open but gated. Three studies in this issue (Flemming, D., P. Sarges, P...
  24. Light W, Brickner D, Brand V, Brickner J. Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol Cell. 2010;40:112-25 pubmed publisher
    ..Thus, interaction of recently repressed INO1 with the NPC alters its chromatin structure and rate of reactivation...
  25. Monette A, Pante N, Mouland A. HIV-1 remodels the nuclear pore complex. J Cell Biol. 2011;193:619-31 pubmed publisher
    ..This detailed analysis highlights the profound effects on NE composition induced by HIV-1 infection, providing further evidence of the magnitude of viral control over the cell biology of its host...
  26. Clever M, Funakoshi T, Mimura Y, Takagi M, Imamoto N. The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells. Nucleus. 2012;3:187-99 pubmed publisher
    ..This process involves the reformation of the nuclear pore complex (NPC), the inner and outer nuclear membranes, and the nuclear lamina...
  27. Dossani Z, Weirich C, Erzberger J, Berger J, Weis K. Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Proc Natl Acad Sci U S A. 2009;106:16251-6 pubmed publisher
    ..Dbp5 localizes to the nuclear pore complex, where its ATPase activity is stimulated by Gle1 and its coactivator inositol hexakisphosphate...
  28. Seo H, Ma Y, Debler E, Wacker D, Kutik S, Blobel G, et al. Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc Natl Acad Sci U S A. 2009;106:14281-6 pubmed publisher
    The Nup84 complex constitutes a key building block in the nuclear pore complex (NPC)...
  29. Dawson T, Lazarus M, Hetzer M, Wente S. ER membrane-bending proteins are necessary for de novo nuclear pore formation. J Cell Biol. 2009;184:659-75 pubmed publisher
    Nucleocytoplasmic transport occurs exclusively through nuclear pore complexes (NPCs) embedded in pores formed by inner and outer nuclear membrane fusion. The mechanism for de novo pore and NPC biogenesis remains unclear...
  30. Butin Israeli V, Ben nun Shaul O, Kopatz I, Adam S, Shimi T, Goldman R, et al. Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry. Nucleus. 2011;2:320-30 pubmed publisher
    The canonical gate of viruses and viral genomes into the nucleus in non-dividing cells is the nuclear pore, embedded within the nuclear envelope...
  31. Wiermer M, Cheng Y, Imkampe J, Li M, Wang D, Lipka V, et al. Putative members of the Arabidopsis Nup107-160 nuclear pore sub-complex contribute to pathogen defense. Plant J. 2012;70:796-808 pubmed publisher
    ..into the nucleus to induce transcription and export of mRNAs for translation in the cytoplasm is mediated by nuclear pore complexes (NPCs) composed of nucleoporin proteins (Nups)...
  32. Goeres J, Chan P, Mukhopadhyay D, Zhang H, Raught B, Matunis M. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. Mol Biol Cell. 2011;22:4868-82 pubmed publisher
    ..ubiquitin-related modifier-specific isopeptidases (also known as sentrin-specific proteases, or SENPs) with nuclear pore complexes (NPCs) is conserved in eukaryotic organisms ranging from yeast to mammals...
  33. Kodiha M, Crampton N, Shrivastava S, Umar R, Stochaj U. Traffic control at the nuclear pore. Nucleus. 2010;1:237-44 pubmed publisher
    ..A growing number of studies support the notion that transport through nuclear pore complexes is intimately linked to cell physiology...
  34. Galigniana M, Echeverria P, Erlejman A, Piwien Pilipuk G. Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore. Nucleus. 2010;1:299-308 pubmed publisher
    ..for the retrotransport of the receptor through the cytoplasm and also facilitates the passage through the nuclear pore. Recent evidence indicates that the hsp90-based chaperone system also interacts with structures of the nuclear ..
  35. Cardarelli F, Lanzano L, Gratton E. Capturing directed molecular motion in the nuclear pore complex of live cells. Proc Natl Acad Sci U S A. 2012;109:9863-8 pubmed publisher
    b>Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. Intrinsically disordered nucleoporins (Nups) form a selective filter inside the NPC, taking a central role in the vital nucleocytoplasmic transport mechanism...
  36. Neumann L, Markaki Y, Mladenov E, Hoffmann D, Buiting K, Horsthemke B. The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein. Hum Mol Genet. 2012;21:4038-48 pubmed publisher
    ..BLAST analysis and InterProScan signature recognition search, we found sequence similarity of C15orf2 to the nuclear pore complex (NPC) protein POM121...
  37. Kaur S, White T, DiGuilio A, Glavy J. The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex. Cell Cycle. 2010;9:3106-11 pubmed
    The gateway for molecular trafficking between the cytoplasm and the nucleus is the Nuclear Pore Complex (NPC)...
  38. Capelson M, Hetzer M. The role of nuclear pores in gene regulation, development and disease. EMBO Rep. 2009;10:697-705 pubmed publisher
    ..Here, we review the transport-dependent and transport-independent roles of NPCs in the regulation of nuclear function and gene expression...
  39. Vollmer B, Schooley A, Sachdev R, Eisenhardt N, Schneider A, Sieverding C, et al. Dimerization and direct membrane interaction of Nup53 contribute to nuclear pore complex assembly. EMBO J. 2012;31:4072-84 pubmed publisher
    b>Nuclear pore complexes (NPCs) fuse the two membranes of the nuclear envelope (NE) to a pore, connecting cytoplasm and nucleoplasm and allowing exchange of macromolecules between these compartments...
  40. Solmaz S, Blobel G, Melcák I. Ring cycle for dilating and constricting the nuclear pore. Proc Natl Acad Sci U S A. 2013;110:5858-63 pubmed publisher
    ..with our previously reported results, we propose a "ring cycle" for dilating and constricting the nuclear pore. In essence, three homooligomeric rings, one consisting of eight modules of Nup58 tetramers, and two, each ..
  41. Kobiler O, Drayman N, Butin Israeli V, Oppenheim A. Virus strategies for passing the nuclear envelope barrier. Nucleus. 2012;3:526-39 pubmed publisher
    ..Most viruses use the canonical nuclear pore complex (NPC) in order to get their genome into the nucleus...
  42. Bilokapic S, Schwartz T. Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex. Proc Natl Acad Sci U S A. 2012;109:15241-6 pubmed
    Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of ~30 different proteins called nucleoporins...
  43. Schooley A, Vollmer B, Antonin W. Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation. Chromosoma. 2012;121:539-54 pubmed publisher
    ..The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed ..
  44. GRUNWALD D, Singer R, ROUT M. Nuclear export dynamics of RNA-protein complexes. Nature. 2011;475:333-41 pubmed publisher
    ..This review addresses the latest studies of RNA export and presents some models for how this complex process may work...
  45. Rothballer A, Kutay U. Poring over pores: nuclear pore complex insertion into the nuclear envelope. Trends Biochem Sci. 2013;38:292-301 pubmed publisher
    ..Its barrier characteristics are determined by nuclear pore complexes (NPCs); huge protein assemblies that guard nucleocytoplasmic compartmentalization...
  46. Makio T, Stanton L, Lin C, Goldfarb D, Weis K, Wozniak R. The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol. 2009;185:459-73 pubmed publisher
    ..established that two homologous nucleoporins, Nup170p and Nup157p, play an essential role in the formation of nuclear pore complexes (NPCs) in Saccharomyces cerevisiae...
  47. Gough S, Slape C, Aplan P. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Blood. 2011;118:6247-57 pubmed publisher
  48. Rodriguez Navarro S, Hurt E. Linking gene regulation to mRNA production and export. Curr Opin Cell Biol. 2011;23:302-9 pubmed publisher
    ..studies have described how nuclear mRNA export depends on the steps preceding and following transport through nuclear pore complexes. These include gene activation, transcription, mRNA processing and mRNP assembly and disassembly...
  49. Cohen S, Au S, Pante N. How viruses access the nucleus. Biochim Biophys Acta. 2011;1813:1634-45 pubmed publisher
    ..envelope is disassembled, (2) viral genome release in the cytoplasm followed by entry of the genome through the nuclear pore complex (NPC), (3) capsid docking at the cytoplasmic side of the NPC, followed by genome release, (4) nuclear ..
  50. Blobel G. Three-dimensional organization of chromatids by nuclear envelope-associated structures. Cold Spring Harb Symp Quant Biol. 2010;75:545-54 pubmed publisher
    ..NE-associated structures, such as nuclear pore complexes (NPCs), the nuclear lamina, and nuclear envelope junctions (NEJs), have evolved to organize, among ..
  51. Maeshima K, Iino H, Hihara S, Funakoshi T, Watanabe A, Nishimura M, et al. Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. Nat Struct Mol Biol. 2010;17:1065-71 pubmed publisher
    Nuclear volume and the number of nuclear pore complexes (NPCs) on the nucleus almost double during interphase in dividing cells. How these events are coordinated with the cell cycle is poorly understood, particularly in mammalian cells...
  52. Miao L, Schulten K. Probing a structural model of the nuclear pore complex channel through molecular dynamics. Biophys J. 2010;98:1658-67 pubmed publisher
    The central pore of a nuclear pore complex (NPC) is filled with unstructured proteins that contain many FG-repeats separated by hydrophilic regions. An example of such protein is nsp1...
  53. Fiserova J, Goldberg M. Nucleocytoplasmic transport in yeast: a few roles for many actors. Biochem Soc Trans. 2010;38:273-7 pubmed publisher
    ..individual proteins such as nucleoporins and karyopherins in the translocation process and relates this to how the organization of the nuclear pore complex effectively facilitates the bidirectional transport between the two compartments.
  54. Imamoto N, Funakoshi T. Nuclear pore dynamics during the cell cycle. Curr Opin Cell Biol. 2012;24:453-9 pubmed publisher
    A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules...
  55. Peters R. Translocation through the nuclear pore: Kaps pave the way. Bioessays. 2009;31:466-77 pubmed publisher
    Transport through the nuclear pore complex (NPC), a keystone of the eukaryotic building plan, is known to involve a large channel and an abundance of phenylalanine-glycine (FG) protein domains serving as binding sites for soluble nuclear ..
  56. Skruzny M, Schneider C, Rácz A, Weng J, Tollervey D, Hurt E. An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. PLoS Biol. 2009;7:e8 pubmed publisher
    ..Swt1 is an RNA endonuclease that participates in quality control of nuclear mRNPs and can associate with the nuclear pore complex (NPC)...
  57. Eisele N, Labokha A, Frey S, Gorlich D, Richter R. Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks - Implications for nuclear pore permeability. Biophys J. 2013;105:1860-70 pubmed publisher
    b>Nuclear pore complexes control the exchange of macromolecules between the cytoplasm and the nucleus...
  58. Valkov E, Dean J, Jani D, Kuhlmann S, Stewart M. Structural basis for the assembly and disassembly of mRNA nuclear export complexes. Biochim Biophys Acta. 2012;1819:578-92 pubmed publisher
    ..Although the translocation of export-competent messenger ribonucleoprotein particles (mRNPs) through the nuclear pore transport channel that is mediated by interactions with nuclear pore proteins (nucleoporins) is relatively well ..
  59. Lu L, Ladinsky M, Kirchhausen T. Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly. J Cell Biol. 2011;194:425-40 pubmed publisher
    During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules...
  60. Kahms M, Hüve J, Wesselmann R, Farr J, Baumgärtel V, Peters R. Lighting up the nuclear pore complex. Eur J Cell Biol. 2011;90:751-8 pubmed publisher
    It is generally accepted that transport through the nuclear pore complex (NPC) involves an abundance of phenylalanine-glycine rich protein domains (FG-domains) that serve as docking sites for soluble nuclear transport receptors (NTRs) and ..
  61. Jamali T, Jamali Y, Mehrbod M, Mofrad M. Nuclear pore complex: biochemistry and biophysics of nucleocytoplasmic transport in health and disease. Int Rev Cell Mol Biol. 2011;287:233-86 pubmed publisher
    b>Nuclear pore complexes (NPCs) are the gateways connecting the nucleoplasm and cytoplasm. This structures are composed of over 30 different proteins and 60-125 MDa of mass depending on type of species...
  62. Jani D, Lutz S, Marshall N, Fischer T, Köhler A, Ellisdon A, et al. Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol Cell. 2009;33:727-37 pubmed publisher
    ..These data indicate Sac3(CID) provides a scaffold within TREX-2 to integrate interactions between protein complexes to facilitate the coupling of transcription and mRNA export during gene expression...