nuclear lamina

Summary

Summary: A lattice of fibrils which covers the entire inner surface of the nuclear envelope and interlinks nuclear pores (NUCLEAR PORE).

Top Publications

  1. Lee C, Chen J, Wang J, Kimura K, Takemoto A, Lu C, et al. Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II. J Virol. 2007;81:5166-80 pubmed
    ..involved, we found that transient expression of EBV BGLF4 kinase induces unscheduled chromosome condensation, nuclear lamina disassembly, and stress fiber rearrangements, independently of cellular DNA replication and Cdc2 activity...
  2. Ostlund C, Folker E, Choi J, Gomes E, Gundersen G, Worman H. Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci. 2009;122:4099-108 pubmed publisher
    ..Our data support a model in which A-type lamins and Sun2 anchor nesprin-2 in the outer nuclear membrane, whereas emerin, Sun1 and actin are dispensable for this anchoring. ..
  3. Worman H, Fong L, Muchir A, Young S. Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest. 2009;119:1825-36 pubmed publisher
    The main function of the nuclear lamina, an intermediate filament meshwork lying primarily beneath the inner nuclear membrane, is to provide structural scaffolding for the cell nucleus...
  4. Parnaik V. Role of nuclear lamins in nuclear organization, cellular signaling, and inherited diseases. Int Rev Cell Mol Biol. 2008;266:157-206 pubmed publisher
    ..The observed interactions of lamins with inner nuclear membrane proteins, chromatin, and various regulatory factors have given important insights into the role of lamins in cellular processes and tissue-specific signaling pathways. ..
  5. Worman H, Courvalin J. Nuclear envelope, nuclear lamina, and inherited disease. Int Rev Cytol. 2005;246:231-79 pubmed
    The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases...
  6. Bridger J, Foeger N, Kill I, Herrmann H. The nuclear lamina. Both a structural framework and a platform for genome organization. FEBS J. 2007;274:1354-61 pubmed
    ..However, the structural features of these lamins and the nature of the factors that assist them in genome organization present an exciting challenge to modern biochemistry and cell biology. ..
  7. Taylor M, Fain P, Sinagra G, Robinson M, Robertson A, Carniel E, et al. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. J Am Coll Cardiol. 2003;41:771-80 pubmed
    ..Mutation screening should be considered in patients with DCM, in particular when clinical predictors of LMNA mutation are present, regardless of family history. ..
  8. Wilson K. Integrity matters: linking nuclear architecture to lifespan. Proc Natl Acad Sci U S A. 2005;102:18767-8 pubmed
  9. Broers J, Hutchison C, Ramaekers F. Laminopathies. J Pathol. 2004;204:478-88 pubmed
    ..Which of these identities underlies the laminopathies, a myriad of genetic diseases caused by mutations in lamins or lamin-associated proteins, is a topic of intense debate. ..

More Information

Publications90

  1. Marschall M, Marzi A, aus dem Siepen P, Jochmann R, Kalmer M, Auerochs S, et al. Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina. J Biol Chem. 2005;280:33357-67 pubmed
    ..at the level of nucleocytoplasmic transport of viral capsids, a process that requires the disassembly of the nuclear lamina. Deletion of the protein kinase gene UL97 from the viral genome showed that the activity of pUL97 plays an ..
  2. Mounkes L, Kozlov S, Burke B, Stewart C. The laminopathies: nuclear structure meets disease. Curr Opin Genet Dev. 2003;13:223-30 pubmed
    ..These diseases and at least two others caused by mutations in other proteins associated with the nuclear lamina are collectively called the laminopathies...
  3. Meuleman W, Peric Hupkes D, Kind J, Beaudry J, Pagie L, Kellis M, et al. Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. Genome Res. 2013;23:270-80 pubmed publisher
    In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for large genomic segments named lamina-associated domains (LADs)...
  4. Kr ger A, Batsios P, Baumann O, Luckert E, Schwarz H, Stick R, et al. Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism. Mol Biol Cell. 2012;23:360-70 pubmed publisher
    Lamins build the nuclear lamina and are required for chromatin organization, gene expression, cell cycle progression, and mechanical stabilization. Despite these universal functions, lamins have so far been found only in metazoans...
  5. Hernandez L, Roux K, Wong E, Mounkes L, Mutalif R, Navasankari R, et al. Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell. 2010;19:413-25 pubmed publisher
    ..These results establish a functional link between the nuclear envelope/lamina and the cell surface/ECM and may provide insights into the role of Wnt signaling and the ECM in aging. ..
  6. Dahl K, Kahn S, Wilson K, Discher D. The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. J Cell Sci. 2004;117:4779-86 pubmed
    ..Our results suggest that the nuclear lamina forms a compressed network shell of interconnected rods that is extensible but limited in compressibility from ..
  7. Camozzi D, Pignatelli S, Valvo C, Lattanzi G, Capanni C, Dal Monte P, et al. Remodelling of the nuclear lamina during human cytomegalovirus infection: role of the viral proteins pUL50 and pUL53. J Gen Virol. 2008;89:731-40 pubmed publisher
    ..In the family Herpesviridae, this process involves alteration of nuclear lamina components by two highly conserved proteins, whose homologues in HCMV are named pUL50 and pUL53...
  8. Guelen L, Pagie L, Brasset E, Meuleman W, Faza M, Talhout W, et al. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature. 2008;453:948-51 pubmed publisher
    ..Microscopy studies have indicated that specific regions of chromosomes are located in close proximity to the nuclear lamina (NL)...
  9. Peric Hupkes D, Meuleman W, Pagie L, Bruggeman S, Solovei I, Brugman W, et al. Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell. 2010;38:603-13 pubmed publisher
    ..To visualize this process in molecular detail, we generated high-resolution maps of genome-nuclear lamina interactions during subsequent differentiation of mouse embryonic stem cells via lineage-committed neural ..
  10. Gonzalez J, Pla D, Perez Sala D, Andres V. A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy. Front Biosci (Schol Ed). 2011;3:1133-46 pubmed
    Lamin A and lamin C (A-type lamins, both encoded by the LMNA gene) are major components of the mammalian nuclear lamina, a complex proteinaceous structure that acts as a scaffold for protein complexes that regulate nuclear structure and ..
  11. Vergnes L, Peterfy M, Bergo M, Young S, Reue K. Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A. 2004;101:10428-33 pubmed
    Lamins are key structural components of the nuclear lamina, an intermediate filament meshwork that lies beneath the inner nuclear membrane. Lamins play a role in nuclear architecture, DNA replication, and gene expression...
  12. Zaremba Czogalla M, Piekarowicz K, Wachowicz K, Kozioł K, Dubińska Magiera M, Rzepecki R. The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C. PLoS ONE. 2012;7:e32649 pubmed publisher
    ..modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis...
  13. Markiewicz E, Ledran M, Hutchison C. Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro. J Cell Sci. 2005;118:409-20 pubmed
    ..In myoblasts transfected with the mutant lamins, this complex was disrupted. These data suggest that remodelling of the nucleoskeleton is necessary for skeletal-muscle differentiation and for correct regulation of Rb pathways. ..
  14. Capell B, Collins F. Human laminopathies: nuclei gone genetically awry. Nat Rev Genet. 2006;7:940-52 pubmed
    Few genes have generated as much recent interest as LMNA, LMNB1 and LMNB2, which encode the components of the nuclear lamina. Over 180 mutations in these genes are associated with at least 13 known diseases--the laminopathies...
  15. Anderson D, Woeller C, Chiang E, Shane B, Stover P. Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J Biol Chem. 2012;287:7051-62 pubmed publisher
    ..In this study, we demonstrate that this pathway forms a multienzyme complex that is associated with the nuclear lamina. SHMT1 or SHMT2? is required for co-localization of dihydrofolate reductase, SHMT, and thymidylate synthase to ..
  16. Yamaguchi A, Katsu Y, Matsuyama M, Yoshikuni M, Nagahama Y. Phosphorylation of the p34(cdc2) target site on goldfish germinal vesicle lamin B3 before oocyte maturation. Eur J Cell Biol. 2006;85:501-17 pubmed
    ..The mechanisms by which lamin B3 is transported into GVs and is assembled to form the nuclear lamina are not well understood...
  17. Lee C, Huang Y, Lin S, Chang Y, Chang Y, Takada K, et al. Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production. J Virol. 2008;82:11913-26 pubmed publisher
    ..we found that Ser-22, Ser-390, and Ser-392 of lamin A are important for the BGLF4-induced disassembly of the nuclear lamina and the EBV reactivation-mediated redistribution of nuclear lamin...
  18. Leach N, Roller R. Significance of host cell kinases in herpes simplex virus type 1 egress and lamin-associated protein disassembly from the nuclear lamina. Virology. 2010;406:127-37 pubmed publisher
    The nuclear lamina is thought to be a steric barrier to the herpesvirus capsid. Disruption of the lamina accompanied by phosphorylation of lamina proteins is a conserved feature of herpesvirus infection...
  19. Worman H. Nuclear lamins and laminopathies. J Pathol. 2012;226:316-25 pubmed publisher
    Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina on the inner aspect of the inner nuclear membrane...
  20. Verstraeten V, Broers J, Ramaekers F, van Steensel M. The nuclear envelope, a key structure in cellular integrity and gene expression. Curr Med Chem. 2007;14:1231-48 pubmed
    ..elegans. In this review, we elaborate on the structure and functions of nuclear lamins, the spectrum of syndromes related to mutations in nuclear envelope components and pathogenic concepts unifying these disorders...
  21. Parks S, Kushner J, Nauman D, Burgess D, Ludwigsen S, Peterson A, et al. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. Am Heart J. 2008;156:161-9 pubmed publisher
    ..We sought to examine the frequency of mutations in LMNA, the gene encoding lamin A/C, in patients with idiopathic (IDC) or familial dilated cardiomyopathy (FDC)...
  22. Cohen M, Santarella R, Wiesel N, Mattaj I, Gruenbaum Y. Electron microscopy of lamin and the nuclear lamina in Caenorhabditis elegans. Methods Cell Biol. 2008;88:411-29 pubmed publisher
    The nuclear lamina is found between the inner nuclear membrane and the peripheral chromatin...
  23. Chang K, Multani P, Sun K, Vincent F, de Pablo Y, Ghosh S, et al. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Mol Biol Cell. 2011;22:1452-62 pubmed publisher
    ..In this study, we show that nuclear lamina dispersion is an early and irreversible trigger for cell death initiated by deregulated Cdk5, rather than a ..
  24. Kim Y, Sharov A, McDole K, Cheng M, Hao H, Fan C, et al. Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011;334:1706-10 pubmed publisher
    B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell proliferation and survival. We found that mouse embryonic stem cells (ESCs) do not need any lamins for self-renewal and pluripotency...
  25. Dahl K, Scaffidi P, Islam M, Yodh A, Wilson K, Misteli T. Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A. 2006;103:10271-10276 pubmed publisher
    The nuclear lamina is a network of structural filaments, the A and B type lamins, located at the nuclear envelope and throughout the nucleus...
  26. Miller M, Furlong W, Pennell L, Geadah M, Hertel L. RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection. J Virol. 2010;84:6483-96 pubmed publisher
    ..previously described as sites of nucleocapsid egress, which is mediated by the localized disruption of the nuclear lamina, promoted by the activities of viral and cellular kinases recruited by the lamina-associated proteins UL50 and ..
  27. Fong L, Ng J, Lammerding J, Vickers T, Meta M, Coté N, et al. Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006;116:743-52 pubmed
    Lamin A and lamin C, both products of Lmna, are key components of the nuclear lamina. In the mouse, a deficiency in both lamin A and lamin C leads to slow growth, muscle weakness, and death by 6 weeks of age...
  28. Verstraeten V, Renes J, Ramaekers F, Kamps M, Kuijpers H, Verheyen F, et al. Reorganization of the nuclear lamina and cytoskeleton in adipogenesis. Histochem Cell Biol. 2011;135:251-61 pubmed publisher
    ..Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process are not...
  29. Houben F, Ramaekers F, Snoeckx L, Broers J. Role of nuclear lamina-cytoskeleton interactions in the maintenance of cellular strength. Biochim Biophys Acta. 2007;1773:675-86 pubmed
    ..Several new interconnecting proteins, such as the nesprins that link the nuclear lamina to the cytoskeleton, have been identified...
  30. Karabinos A, Schünemann J, Meyer M, Aebi U, Weber K. The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity. J Mol Biol. 2003;325:241-7 pubmed
    ..C.elegans lamin in low ionic strength Tris-buffers at a pH of 7.2-7.4 provides a stable population of lamin IFs. Some implications of this filament formation are discussed...
  31. Kind J, Pagie L, Ortabozkoyun H, Boyle S, de Vries S, Janssen H, et al. Single-cell dynamics of genome-nuclear lamina interactions. Cell. 2013;153:178-92 pubmed publisher
    The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina associated domains (LADs). The dynamics of these interactions and the relation to epigenetic modifications are poorly understood...
  32. Ralle T, Grund C, Franke W, Stick R. Intranuclear membrane structure formations by CaaX-containing nuclear proteins. J Cell Sci. 2004;117:6095-104 pubmed
    The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the nuclear envelope. Association of lamins with the inner nuclear membrane is mediated by specific modifications in the CaaX motif at their C-termini...
  33. Peric Hupkes D, van Steensel B. Role of the nuclear lamina in genome organization and gene expression. Cold Spring Harb Symp Quant Biol. 2010;75:517-24 pubmed publisher
    The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation...
  34. Ohba T, Schirmer E, Nishimoto T, Gerace L. Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore. J Cell Biol. 2004;167:1051-62 pubmed
    ..measures the movement of transmembrane reporters from the ER to the INM by rapamycin-mediated trapping at the nuclear lamina. Reporter constructs with small (<30 kD) cytosolic and lumenal domains rapidly accumulated at the INM...
  35. van Bemmel J, Pagie L, Braunschweig U, Brugman W, Meuleman W, Kerkhoven R, et al. The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome. PLoS ONE. 2010;5:e15013 pubmed publisher
    Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression...
  36. Hawryluk Gara L, Shibuya E, Wozniak R. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol Biol Cell. 2005;16:2382-94 pubmed
    ..On basis of these data, we propose a model in which Nup53 is positioned near the pore membrane and the lamina where it anchors an NPC subcomplex containing Nup93, Nup155, and Nup205. ..
  37. Raz V, Carlotti F, Vermolen B, van der Poel E, Sloos W, Knaän Shanzer S, et al. Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells. J Cell Sci. 2006;119:4247-56 pubmed
    ..We found that caspase-8 induces alteration of the nuclear lamina and a subsequent spatial reorganization of both centromeres, which are shifted towards a peripheral ..
  38. Kubben N, Voncken J, Misteli T. Mapping of protein- and chromatin-interactions at the nuclear lamina. Nucleus. 2010;1:460-71 pubmed publisher
    ..Here we summarize and critically discuss recent technology to analyze lamina-protein and-chromatin interactions...
  39. Attali R, Warwar N, Israel A, Gurt I, McNally E, Puckelwartz M, et al. Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis. Hum Mol Genet. 2009;18:3462-9 pubmed publisher
    ..These data indicate that mutations of nesprin-1 which interacts with lamin A/C may lead to at least two distinct human disease phenotypes, myopathic or neurological, a feature similar to that found in laminopathies...
  40. Ballester M, Rodríguez Cariño C, Perez M, Gallardo C, Rodriguez J, Salas M, et al. Disruption of nuclear organization during the initial phase of African swine fever virus infection. J Virol. 2011;85:8263-9 pubmed publisher
  41. Malhas A, Lee C, Sanders R, Saunders N, Vaux D. Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression. J Cell Biol. 2007;176:593-603 pubmed
    ..We also demonstrate that the position of mouse chromosome 18 but not 19 is dependent on such a stable nuclear lamina. The results implicate processed lamin B1 in the control of gene expression as well as chromosome position.
  42. Hamirally S, Kamil J, Ndassa Colday Y, Lin A, Jahng W, Baek M, et al. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog. 2009;5:e1000275 pubmed publisher
    The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress)...
  43. Ben Harush K, Wiesel N, Frenkiel Krispin D, Moeller D, Soreq E, Aebi U, et al. The supramolecular organization of the C. elegans nuclear lamin filament. J Mol Biol. 2009;386:1392-402 pubmed publisher
    ..IF) proteins forming a distinct meshwork-like layer adhering to the inner nuclear membrane, called the nuclear lamina. Here, we present for the first time, the three-dimensional supramolecular organization of lamin 10 nm ..
  44. Bridger J, Kill I. Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis. Exp Gerontol. 2004;39:717-24 pubmed
    ..These data provide clues as to the cellular basis for premature aging in HGPS and support the view that cellular senescence and tissue homeostasis are important factors in the normal aging process...
  45. Parnaik V, Chaturvedi P, Muralikrishna B. Lamins, laminopathies and disease mechanisms: possible role for proteasomal degradation of key regulatory proteins. J Biosci. 2011;36:471-9 pubmed
    ..New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis...
  46. Hiraoka Y, Maekawa H, Asakawa H, Chikashige Y, Kojidani T, Osakada H, et al. Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres. Genes Cells. 2011;16:1000-11 pubmed publisher
    ..Considering that all three INM proteins interact with Sad1, these results suggest that Ima1, Lem2 and Man1 play at least partially redundant roles for nuclear membrane organization...
  47. Righolt C, van t Hoff M, Vermolen B, Young I, Raz V. Robust nuclear lamina-based cell classification of aging and senescent cells. Aging (Albany NY). 2011;3:1192-201 pubmed
    Changes in the shape of the nuclear lamina are exhibited in senescent cells, as well as in cells expressing mutations in lamina genes...
  48. Graham A, Kiss D, Andrulis E. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Mol Biol Cell. 2006;17:1399-409 pubmed
    ..Strikingly, dRrp44/dDis3 and dRrp41/dSki6 colocalize with the nuclear lamina and often exhibit a restricted and asymmetric distribution at the nuclear periphery...
  49. Malhas A, Lee C, Vaux D. Lamin B1 controls oxidative stress responses via Oct-1. J Cell Biol. 2009;184:45-55 pubmed publisher
    ..Sequestration of Oct-1 at the nuclear periphery by lamin B1 may be a mechanism by which the nuclear envelope can regulate gene expression and contribute to the cellular response to stress, development, and aging...
  50. Milon B, Cheng H, Tselebrovsky M, Lavrov S, Nenasheva V, Mikhaleva E, et al. Role of histone deacetylases in gene regulation at nuclear lamina. PLoS ONE. 2012;7:e49692 pubmed publisher
    ..These findings demonstrate the manifold and central involvement of class I HDACs in regulation of lamina-associated genes, illuminating a mechanism by which these enzymes can orchestrate normal and pathological development...
  51. Simpson Holley M, Baines J, Roller R, Knipe D. Herpes simplex virus 1 U(L)31 and U(L)34 gene products promote the late maturation of viral replication compartments to the nuclear periphery. J Virol. 2004;78:5591-600 pubmed
    ..Surrounding the chromatin layer is the nuclear lamina, a further host cell barrier to egress...
  52. Taddei A, Hediger F, Neumann F, Gasser S. The function of nuclear architecture: a genetic approach. Annu Rev Genet. 2004;38:305-45 pubmed
  53. Gruenbaum Y, Margalit A, Goldman R, Shumaker D, Wilson K. The nuclear lamina comes of age. Nat Rev Mol Cell Biol. 2005;6:21-31 pubmed
  54. Gerace L, Huber M. Nuclear lamina at the crossroads of the cytoplasm and nucleus. J Struct Biol. 2012;177:24-31 pubmed publisher
    The nuclear lamina is a protein meshwork that lines the nuclear envelope in metazoan cells...
  55. Bank E, Ben Harush K, Wiesel Motiuk N, Barkan R, Feinstein N, Lotan O, et al. A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans. Mol Biol Cell. 2011;22:2716-28 pubmed publisher
    ..These results show that changes in lamin filament structure can translate into disease-like phenotypes via altering the localization of nuclear lamina proteins, and suggest a model for how the ?K32 lamin mutation may cause EDMD in humans.
  56. Kumaran R, Spector D. A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. J Cell Biol. 2008;180:51-65 pubmed publisher
    The peripheral nuclear lamina, which is largely but not entirely associated with inactive chromatin, is considered to be an important determinant of nuclear structure and gene expression...
  57. Busch A, Kiel T, Heupel W, Wehnert M, Hübner S. Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants. Exp Cell Res. 2009;315:2373-85 pubmed publisher
    Lamins, which form the nuclear lamina, not only constitute an important determinant of nuclear architecture, but additionally play essential roles in many nuclear functions...
  58. Milbradt J, Auerochs S, Sticht H, Marschall M. Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex. J Gen Virol. 2009;90:579-90 pubmed publisher
    ..capsids traversing the nuclear envelope is dependent on a locally restricted destabilization of the rigid nuclear lamina. It has been suggested that the multi-component nuclear egress complex (NEC) that is formed is comprised of ..
  59. Goldberg M, Fiserova J, Huttenlauch I, Stick R. A new model for nuclear lamina organization. Biochem Soc Trans. 2008;36:1339-43 pubmed publisher
    ..When lamin A is expressed in oocytes, it forms organized bundles on top of the B lamina. This has led to a new model for lamina organization which is discussed in the present paper...
  60. Berman B, Weisenberger D, Aman J, Hinoue T, Ramjan Z, Liu Y, et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet. 2011;44:40-6 pubmed publisher
    ..domains covered nearly half of the genome and coincided with late replication and attachment to the nuclear lamina in human cell lines...
  61. Hutchison C. Lamins: building blocks or regulators of gene expression?. Nat Rev Mol Cell Biol. 2002;3:848-58 pubmed
    ..These influences require the lamins to have dynamic properties and dual identities--as building blocks and transcriptional regulators. Which one of these identities underlies a myriad of genetic diseases is a topic of intense debate...
  62. Jung H, Nobumori C, Goulbourne C, Tu Y, Lee J, Tatar A, et al. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013;110:E1923-32 pubmed publisher
    ..The nuclear lamina in migrating neurons was pulled away from the chromatin so that the chromatin was left "naked" (free ..
  63. Worman H, Courvalin J. The nuclear lamina and inherited disease. Trends Cell Biol. 2002;12:591-8 pubmed
    Inherited disorders of the nuclear lamina present some of the most intriguing puzzles in cell biology...
  64. Wiesel N, Mattout A, Melcer S, Melamed Book N, Herrmann H, Medalia O, et al. Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Proc Natl Acad Sci U S A. 2008;105:180-5 pubmed
    Lamins are nuclear intermediate filament proteins and the major building blocks of the nuclear lamina. Besides providing nuclear shape and mechanical stability, lamins are required for chromatin organization, transcription regulation, DNA ..
  65. Gruenbaum Y, Goldman R, Meyuhas R, Mills E, Margalit A, Fridkin A, et al. The nuclear lamina and its functions in the nucleus. Int Rev Cytol. 2003;226:1-62 pubmed
    The nuclear lamina is a structure near the inner nuclear membrane and the peripheral chromatin. It is composed of lamins, which are also present in the nuclear interior, and lamin-associated proteins...
  66. Takamori Y, Tamura Y, Kataoka Y, Cui Y, Seo S, Kanazawa T, et al. Differential expression of nuclear lamin, the major component of nuclear lamina, during neurogenesis in two germinal regions of adult rat brain. Eur J Neurosci. 2007;25:1653-62 pubmed
    ..Our results suggest that the alteration of nuclear lamina structure is coupled with the progression of neuronal differentiation.
  67. Broers J, Ramaekers F, Bonne G, Yaou R, Hutchison C. Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev. 2006;86:967-1008 pubmed
    ..It is concluded that lamins seem to be key players in, among others, controlling the process of cellular ageing, since disturbance in lamin protein structure gives rise to several forms of premature ageing...
  68. Bjerke S, Roller R. Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress. Virology. 2006;347:261-76 pubmed
    ..The data presented in this paper argue for crucial roles for both UL34 and US3 in regulating the state of the nuclear lamina during viral infection.
  69. Ho J, Zhou T, Lai W, Huang Y, Chan Y, Li X, et al. Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C. Aging (Albany NY). 2011;3:380-90 pubmed
    ..Lamins are the main constituents of the nuclear lamina, a filamentous meshwork associated with the inner nuclear membrane that provides mechanical stability and ..
  70. Cohen M, Tzur Y, Neufeld E, Feinstein N, Delannoy M, Wilson K, et al. Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos. J Struct Biol. 2002;140:232-40 pubmed
    ..Taken together, these results show evolutionarily conserved protein localization, interactions, and functions of the C. elegans nuclear envelope...
  71. Milbradt J, Webel R, Auerochs S, Sticht H, Marschall M. Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus. J Biol Chem. 2010;285:13979-89 pubmed publisher
    ..viral and cellular proteins, in particular protein kinases with the capacity to induce destabilization of the nuclear lamina. Viral protein kinase pUL97 and cellular protein kinase C (PKC) play important roles by phosphorylating ..
  72. Bank E, Gruenbaum Y. Caenorhabditis elegans as a model system for studying the nuclear lamina and laminopathic diseases. Nucleus. 2011;2:350-7 pubmed publisher
    The nuclear lamina is a protein-rich network located directly underneath the inner nuclear membrane of metazoan nuclei...
  73. Reynolds A, Liang L, Baines J. Conformational changes in the nuclear lamina induced by herpes simplex virus type 1 require genes U(L)31 and U(L)34. J Virol. 2004;78:5564-75 pubmed
    ..solubility of lamins A and C (lamin A/C) was not markedly increased, HSV induced conformational changes in the nuclear lamina of infected cells, as viewed after staining with three different lamin A/C-specific antibodies...
  74. Park R, Baines J. Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B. J Virol. 2006;80:494-504 pubmed
    ..The data suggest a model in which kinases that normally disassemble the nuclear lamina during apoptosis are recruited to the nuclear membrane through functions requiring UL31 and UL34...
  75. Tzur Y, Hersh B, Horvitz H, Gruenbaum Y. Fate of the nuclear lamina during Caenorhabditis elegans apoptosis. J Struct Biol. 2002;137:146-53 pubmed
    ..These results suggest that lamin cleavage probably is not essential for apoptosis in C. elegans...
  76. Panorchan P, Schafer B, Wirtz D, Tseng Y. Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina. J Biol Chem. 2004;279:43462-7 pubmed
    In prophase cells, lamin B1 is the major component of the nuclear lamina, a filamentous network underlying the nucleoplasmic side of the nuclear membrane, whereas lamin A/C is dissociated from the scaffold...
  77. Dorner D, Vlcek S, Foeger N, Gajewski A, Makolm C, Gotzmann J, et al. Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J Cell Biol. 2006;173:83-93 pubmed
    ..The effects of LAP2alpha on cell cycle progression and differentiation may be highly relevant for the cell- and tissue-specific phenotypes observed in laminopathic diseases...
  78. Heessen S, Fornerod M. The inner nuclear envelope as a transcription factor resting place. EMBO Rep. 2007;8:914-9 pubmed
    ..The mechanisms of inner nuclear membrane association are diverse, and include regulated associations with the nuclear lamina and integral membrane proteins...
  79. Schermelleh L, Carlton P, Haase S, Shao L, Winoto L, Kner P, et al. Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science. 2008;320:1332-6 pubmed publisher
    ..By simultaneously imaging chromatin, nuclear lamina, and the nuclear pore complex (NPC), we observed several features that escape detection by conventional ..
  80. Kind J, van Steensel B. Genome-nuclear lamina interactions and gene regulation. Curr Opin Cell Biol. 2010;22:320-5 pubmed publisher
    The nuclear lamina, a filamentous protein network that coats the inner nuclear membrane, has long been thought to interact with specific genomic loci and regulate their expression...
  81. Dechat T, Gesson K, Foisner R. Lamina-independent lamins in the nuclear interior serve important functions. Cold Spring Harb Symp Quant Biol. 2010;75:533-43 pubmed publisher
    Nuclear lamins were originally described as the main constituents of the nuclear lamina, a filamentous meshwork closely associated with the inner nuclear membrane...