nuclear envelope

Summary

Summary: The membrane system of the CELL NUCLEUS that surrounds the nucleoplasm. It consists of two concentric membranes separated by the perinuclear space. The structures of the envelope where it opens to the cytoplasm are called the nuclear pores (NUCLEAR PORE).

Top Publications

  1. Minn I, Rolls M, Hanna Rose W, Malone C. SUN-1 and ZYG-12, mediators of centrosome-nucleus attachment, are a functional SUN/KASH pair in Caenorhabditis elegans. Mol Biol Cell. 2009;20:4586-95 pubmed publisher
    ..mini KASH domain is functional and, in combination with a portion of coiled-coil domain, is sufficient for nuclear envelope localization...
  2. Blau Wasser R, Euteneuer U, Xiong H, Gassen B, Schleicher M, Noegel A. CP250, a novel acidic coiled-coil protein of the Dictyostelium centrosome, affects growth, chemotaxis, and the nuclear envelope. Mol Biol Cell. 2009;20:4348-61 pubmed publisher
    ..Furthermore, loss of CP250 affected the nuclear envelope and led to reduced amounts and altered distribution of Sun-1, a conserved nuclear envelope protein that ..
  3. Melloy P, Shen S, White E, Rose M. Distinct roles for key karyogamy proteins during yeast nuclear fusion. Mol Biol Cell. 2009;20:3773-82 pubmed publisher
    ..for nuclear fusion are found at the surface (Prm3p) and within the lumen (Kar2p, Kar5p, and Kar8p) of the nuclear envelope (NE)...
  4. Tapley E, Ly N, Starr D. Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane. Mol Biol Cell. 2011;22:1739-52 pubmed publisher
    ..UNC-84 recruits KASH proteins to the outer nuclear membrane to bridge the nuclear envelope (NE), mediating nuclear positioning...
  5. Dittmer T, Misteli T. The lamin protein family. Genome Biol. 2011;12:222 pubmed publisher
    ..Mutations in lamins cause a large number of diverse human diseases, collectively known as the laminopathies, underscoring their functional importance. ..
  6. Ferreira H, Luke B, Schober H, Kalck V, Lingner J, Gasser S. The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nat Cell Biol. 2011;13:867-74 pubmed publisher
    Budding yeast telomeres are reversibly bound at the nuclear envelope through two partially redundant pathways that involve the Sir2/3/4 silencing complex and the Yku70/80 heterodimer...
  7. Klupp B, Granzow H, Mettenleiter T. Nuclear envelope breakdown can substitute for primary envelopment-mediated nuclear egress of herpesviruses. J Virol. 2011;85:8285-92 pubmed publisher
    ..Ultrastructural analyses demonstrated that this effect was due to virus-induced disintegration of the nuclear envelope, thereby releasing immature and mature capsids into the cytosol for secondary envelopment...
  8. Butin Israeli V, Ben nun Shaul O, Kopatz I, Adam S, Shimi T, Goldman R, et al. Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry. Nucleus. 2011;2:320-30 pubmed publisher
    ..of viruses and viral genomes into the nucleus in non-dividing cells is the nuclear pore, embedded within the nuclear envelope. However, we found that for SV40, the nuclear envelope poses a major hurdle to infection: FISH analysis ..
  9. Steglich B, Filion G, van Steensel B, Ekwall K. The inner nuclear membrane proteins Man1 and Ima1 link to two different types of chromatin at the nuclear periphery in S. pombe. Nucleus. 2012;3:77-87 pubmed
    ..Our results point to a role of nuclear membrane proteins in organizing chromatin domains and loops. ..

More Information

Publications112 found, 100 shown here

  1. Vagnarelli P, Earnshaw W. Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus. 2012;3:138-42 pubmed publisher
    ..We have identified Repo-Man/PP1 as a phosphatase complex that regulates temporally and spatially chromatin re-organization and nuclear envelope re-formation during anaphase-telophase.
  2. Batsios P, Peter T, Baumann O, Stick R, Meyer I, Gräf R. A lamin in lower eukaryotes?. Nucleus. 2012;3:237-43 pubmed publisher
    ..Based on the current knowledge, we draw a model for nuclear envelope organization in Dictyostelium in this Extra View and we review the experimental data that justified this ..
  3. Elhanany Tamir H, Yu Y, Shnayder M, Jain A, WELTE M, Volk T. Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules. J Cell Biol. 2012;198:833-46 pubmed publisher
    ..or in klar and msp-300 double heterozygous mutants, the MSP-300 nuclear ring and the aMTs retracted from the nuclear envelope, abrogating this even nuclear spacing...
  4. Kracklauer M, Link J, Alsheimer M. LINCing the nuclear envelope to gametogenesis. Curr Top Dev Biol. 2013;102:127-57 pubmed publisher
    ..LINC complexes comprise SUN and KASH domain proteins that form nuclear envelope (NE) bridges, linking the nucleoskeleton to the cytoskeleton...
  5. Dettmann A, Heilig Y, Ludwig S, Schmitt K, Illgen J, Fleißner A, et al. HAM-2 and HAM-3 are central for the assembly of the Neurospora?STRIPAK complex at the nuclear envelope and regulate nuclear accumulation of the MAP kinase MAK-1 in a MAK-2-dependent manner. Mol Microbiol. 2013;90:796-812 pubmed publisher
    ..describe that the core STRIPAK components HAM-2 and HAM-3 are central for the assembly of the complex at the nuclear envelope, while the phosphatase PPG-1 only transiently associates with this central subcomplex...
  6. Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease. J Cell Biol. 2014;205:133-41 pubmed publisher
    In eukaryotic cells the nuclear genome is enclosed by the nuclear envelope (NE)...
  7. Desai P, Pryce E, Henson B, Luitweiler E, Cothran J. Reconstitution of the Kaposi's sarcoma-associated herpesvirus nuclear egress complex and formation of nuclear membrane vesicles by coexpression of ORF67 and ORF69 gene products. J Virol. 2012;86:594-8 pubmed publisher
    ..When the two proteins are expressed together, numerous virion-size nuclear membrane-derived vesicles were evident at the nuclear margins...
  8. Vargas J, Hatch E, Anderson D, Hetzer M. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus. 2012;3:88-100 pubmed publisher
    Neoplastic cells are often characterized by specific morphological abnormalities of the nuclear envelope (NE), which have been used for cancer diagnosis for more than a century...
  9. Laurell E, Beck K, Krupina K, Theerthagiri G, Bodenmiller B, Horvath P, et al. Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry. Cell. 2011;144:539-50 pubmed publisher
    ..Nuclei carrying a phosphodeficient mutant of Nup98 undergo nuclear envelope breakdown slowly, such that both the dissociation of Nup98 from NPCs and the permeabilization of the nuclear ..
  10. Brachner A, Foisner R. Evolvement of LEM proteins as chromatin tethers at the nuclear periphery. Biochem Soc Trans. 2011;39:1735-41 pubmed publisher
    The nuclear envelope in eukaryotic cells has important roles in chromatin organization. The inner nuclear membrane contains over 60 transmembrane proteins...
  11. Maciejczyk A, Jagoda E, Wysocka T, Matkowski R, Gyorffy B, Lage H, et al. ABCC2 (MRP2, cMOAT) localized in the nuclear envelope of breast carcinoma cells correlates with poor clinical outcome. Pathol Oncol Res. 2012;18:331-42 pubmed publisher
    ..Immunohistochemical studies demonstrated that ABCC2 expression may be manifested in nuclear envelope of neoplastic cells (ABCC2n) as well as in their cell membrane and cytoplasm (ABCC2c)...
  12. Fujitomo T, Daigo Y, Matsuda K, Ueda K, Nakamura Y. Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis. Cancer Res. 2012;72:4110-8 pubmed publisher
    ..Here we report the identification of the integral nuclear envelope protein TMEM209 as a critical driver of human lung cancer growth and survival...
  13. Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, et al. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Res. 2012;22:1440-52 pubmed publisher
    ..are composed of SUN and KASH domain-containing proteins and bridge the inner and outer membranes of the nuclear envelope. LINC complexes play critical roles in nuclear positioning, cell polarization and cellular stiffness...
  14. Rothballer A, Kutay U. Poring over pores: nuclear pore complex insertion into the nuclear envelope. Trends Biochem Sci. 2013;38:292-301 pubmed publisher
    The nuclear boundary is formed by the nuclear envelope (NE), a double membrane system that establishes a selective barrier between the nucleoplasm and the cytoplasm...
  15. English A, Voeltz G. Endoplasmic reticulum structure and interconnections with other organelles. Cold Spring Harb Perspect Biol. 2013;5:a013227 pubmed publisher
    ..continuous membrane-bound organelle comprised of functionally and structurally distinct domains including the nuclear envelope, peripheral tubular ER, peripheral cisternae, and numerous membrane contact sites at the plasma membrane, ..
  16. Giorda K, Raghava S, Hebert D. The Simian virus 40 late viral protein VP4 disrupts the nuclear envelope for viral release. J Virol. 2012;86:3180-92 pubmed publisher
    ..The integrity of the nuclear envelope was compromised in these cells, resulting in the mislocalization of a soluble nuclear marker...
  17. Chen S, Novick P, Ferro Novick S. ER structure and function. Curr Opin Cell Biol. 2013;25:428-33 pubmed publisher
    The ER forms a contiguous structure of interconnected sheets and tubules that spreads from the nuclear envelope to the cell cortex...
  18. Gardner J, Smoyer C, Stensrud E, Alexander R, Gogol M, Wiegraebe W, et al. Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z. J Cell Biol. 2011;193:489-507 pubmed publisher
    ..We demonstrate that H2A.Z is required to target a soluble Mps3 fragment to the nucleus and to localize full-length Mps3 in the INM, indicating that H2A.Z has a novel chromatin-independent function in INM targeting of SUN proteins. ..
  19. Tapley E, Starr D. Connecting the nucleus to the cytoskeleton by SUN-KASH bridges across the nuclear envelope. Curr Opin Cell Biol. 2013;25:57-62 pubmed publisher
    ..these processes is the assembly and function of conserved SUN-KASH bridges, or LINC complexes, that span the nuclear envelope. Recent studies provide details of the higher order assembly and targeting of SUN proteins to the inner ..
  20. Razafsky D, Zang S, Hodzic D. UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning. Biochem Soc Trans. 2011;39:1790-4 pubmed publisher
    ..LINC (linker of nucleoskeleton and cytoskeleton) complexes are macromolecular scaffolds that span the nuclear envelope and physically connect the nuclear interior to different cytoskeletal elements and molecular motors, thereby ..
  21. Capo Chichi C, Cai K, Smedberg J, Ganjei Azar P, Godwin A, Xu X. Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. Chin J Cancer. 2011;30:415-25 pubmed
    ..We conclude that the loss of nuclear envelope structural proteins lamin A/C in breast cancer underlies the two hallmarks of cancer aberrations in nuclear ..
  22. Asencio C, Davidson I, Santarella Mellwig R, Ly Hartig T, Mall M, Wallenfang M, et al. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Cell. 2012;150:122-35 pubmed publisher
    Mitosis in metazoa requires nuclear envelope (NE) disassembly and reassembly. NE disassembly is driven by multiple phosphorylation events...
  23. Cohen S, Marr A, Garcin P, Pante N. Nuclear envelope disruption involving host caspases plays a role in the parvovirus replication cycle. J Virol. 2011;85:4863-74 pubmed publisher
    ..early during infection the parvovirus minute virus of mice (MVM) causes small, transient disruptions of the nuclear envelope (NE). We have now investigated the mechanism used by MVM to disrupt the NE...
  24. Schooley A, Vollmer B, Antonin W. Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation. Chromosoma. 2012;121:539-54 pubmed publisher
    The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed ..
  25. Helfand B, Wang Y, Pfleghaar K, Shimi T, Taimen P, Shumaker D. Chromosomal regions associated with prostate cancer risk localize to lamin B-deficient microdomains and exhibit reduced gene transcription. J Pathol. 2012;226:735-45 pubmed publisher
    ..These results imply that lamins are involved in chromatin organization and Pol II transcription, and provide insights into the development and progression of CaP. ..
  26. Bermejo R, Kumar A, Foiani M. Preserving the genome by regulating chromatin association with the nuclear envelope. Trends Cell Biol. 2012;22:465-73 pubmed publisher
    The nuclear envelope compartmentalizes chromatin within eukaryotic cells and influences diverse cellular functions by controlling nucleocytoplasmic trafficking...
  27. Furth N, Gertman O, Shiber A, Alfassy O, Cohen I, Rosenberg M, et al. Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope. Mol Biol Cell. 2011;22:4726-39 pubmed publisher
    ..quality control pathway mediated by the E3 ubiquitin (Ub) ligase Doa10p at the endoplasmic reticulum (ER)/nuclear envelope membrane...
  28. Goyal U, Blackstone C. Untangling the web: mechanisms underlying ER network formation. Biochim Biophys Acta. 2013;1833:2492-8 pubmed publisher
    The ER is a continuous membrane system consisting of the nuclear envelope, flat sheets often studded with ribosomes, and a polygonal network of highly-curved tubules extending throughout the cell...
  29. Hayashi H, Kimura K, Kimura A. Localized accumulation of tubulin during semi-open mitosis in the Caenorhabditis elegans embryo. Mol Biol Cell. 2012;23:1688-99 pubmed publisher
    ..This accumulation coincided with nuclear envelope permeabilization, suggesting that permeabilization might trigger the accumulation...
  30. Abrams E, Zhang H, Marlow F, KAPP L, Lu S, Mullins M. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Cell. 2012;150:521-32 pubmed publisher
    ..are one such modification, mitotic intermediates wherein individual chromatin masses are surrounded by nuclear envelope; the karyomeres then fuse to form a single mononucleus...
  31. Jaspersen S, Ghosh S. Nuclear envelope insertion of spindle pole bodies and nuclear pore complexes. Nucleus. 2012;3:226-36 pubmed publisher
    The defining feature of eukaryotic cells is the double lipid bilayer of the nuclear envelope (NE) that serves as a physical barrier separating the genome from the cytosol...
  32. Lu W, Schneider M, Neumann S, Jaeger V, Taranum S, Munck M, et al. Nesprin interchain associations control nuclear size. Cell Mol Life Sci. 2012;69:3493-509 pubmed publisher
    Nesprins-1/-2/-3/-4 are nuclear envelope proteins, which connect nuclei to the cytoskeleton. The largest nesprin-1/-2 isoforms (termed giant) tether F-actin through their N-terminal actin binding domain (ABD)...
  33. Schreiber K, Kennedy B. When lamins go bad: nuclear structure and disease. Cell. 2013;152:1365-75 pubmed publisher
    Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a group of phenotypically diverse genetic disorders known as laminopathies, which have symptoms that range from muscular dystrophy to neuropathy ..
  34. Jiang X, Yang M, Huang L, Li C, Xing X. SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis. DNA Cell Biol. 2011;30:875-82 pubmed publisher
    ..To date, several members--SUN1, SUN2, SUN3, and SPAG4--have been identified as nuclear envelope (NE) proteins...
  35. Kupke T, Di Cecco L, Muller H, Neuner A, Adolf F, Wieland F, et al. Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication. EMBO J. 2011;30:3337-52 pubmed publisher
    Spindle pole bodies (SPBs), like nuclear pore complexes, are embedded in the nuclear envelope (NE) at sites of fusion of the inner and outer nuclear membranes...
  36. Hatch E, Fischer A, Deerinck T, Hetzer M. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 2013;154:47-60 pubmed publisher
    During mitotic exit, missegregated chromosomes can recruit their own nuclear envelope (NE) to form micronuclei (MN)...
  37. Zullo J, Demarco I, Pique Regi R, Gaffney D, Epstein C, Spooner C, et al. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell. 2012;149:1474-87 pubmed publisher
    ..Knockdown of cKrox or HDAC3 results in dissociation of LASs/LADs from the nuclear lamina. These results reveal a mechanism that couples nuclear compartmentalization of chromatin domains with the control of gene activity. ..
  38. Hou H, Zhou Z, Wang Y, Wang J, Kallgren S, Kurchuk T, et al. Csi1 links centromeres to the nuclear envelope for centromere clustering. J Cell Biol. 2012;199:735-44 pubmed publisher
    ..Schizosaccharomyces pombe, the centromeres of each chromosome are clustered together and attached to the nuclear envelope near the site of the spindle pole body during interphase...
  39. Yokoi F, Dang M, Yang G, Li J, Doroodchi A, Zhou T, et al. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models. Behav Brain Res. 2012;227:12-20 pubmed publisher
    ..SGCE is maternally imprinted and paternally expressed. Abnormal nuclear envelope has been reported in mouse models of DYT1 generalized torsion dystonia...
  40. Hiraoka Y, Maekawa H, Asakawa H, Chikashige Y, Kojidani T, Osakada H, et al. Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres. Genes Cells. 2011;16:1000-11 pubmed publisher
    ..Considering that all three INM proteins interact with Sad1, these results suggest that Ima1, Lem2 and Man1 play at least partially redundant roles for nuclear membrane organization...
  41. Zwaenepoel O, Tzenaki N, Vergetaki A, Makrigiannakis A, Vanhaesebroeck B, Papakonstanti E. Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110? isoform of PI 3-kinase. FASEB J. 2012;26:691-706 pubmed publisher
    ..We show here that functional CSF-1Rs are present at the nuclear envelope of various cell types, including primary macrophages, human cancer cell lines, and primary human carcinomas...
  42. Bourgeois B, Gilquin B, Tellier Lebegue C, Ostlund C, Wu W, Perez J, et al. Inhibition of TGF-? signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A. Sci Signal. 2013;6:ra49 pubmed publisher
    ..These results demonstrate a nuclear envelope-localized mechanism of inactivating TGF-? signaling in which MAN1 competes with transcription factors for ..
  43. Graumann K, Evans D. Nuclear envelope dynamics during plant cell division suggest common mechanisms between kingdoms. Biochem J. 2011;435:661-7 pubmed publisher
    Behaviour of the NE (nuclear envelope) during open mitosis has been explored extensively in metazoans, but lack of native markers has limited similar investigations in plants...
  44. Chan J, Poon B, Salvi J, Olsen J, Emili A, Mekhail K. Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains. Dev Cell. 2011;20:867-79 pubmed publisher
    Heterochromatin, or silent chromatin, preferentially resides at the nuclear envelope. Telomeres and rDNA repeats are the two major perinuclear silent chromatin domains of Saccharomyces cerevisiae...
  45. Vander Heyden A, Naismith T, Snapp E, Hanson P. Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum. EMBO J. 2011;30:3217-31 pubmed publisher
  46. Friederichs J, Ghosh S, Smoyer C, McCroskey S, Miller B, Weaver K, et al. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. PLoS Genet. 2011;7:e1002365 pubmed publisher
    The budding yeast spindle pole body (SPB) is anchored in the nuclear envelope so that it can simultaneously nucleate both nuclear and cytoplasmic microtubules...
  47. Horigome C, Mizuta K. Ribosome biogenesis factors working with a nuclear envelope SUN domain protein: new players in the solar system. Nucleus. 2012;3:22-8 pubmed
    ..In this organism, Ebp2 and Rrs1 are found in the nucleolus and at the nuclear periphery. At the nuclear envelope, these proteins interact with a membrane-spanning SUN domain protein, Mps3, and play roles in telomere ..
  48. Tran D, Chalhoub A, Schooley A, Zhang W, Ngsee J. A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect. J Cell Sci. 2012;125:2831-6 pubmed publisher
    ..We show that the mutation also causes a nuclear envelope defect...
  49. Winey M, Bloom K. Mitotic spindle form and function. Genetics. 2012;190:1197-224 pubmed publisher
    ..Microtubules are nucleated from a crystalline array of proteins organized in the nuclear envelope, known as the spindle pole body in yeast (analogous to the centrosome in larger eukaryotes)...
  50. Speese S, Ashley J, Jokhi V, Nunnari J, Barria R, Li Y, et al. Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell. 2012;149:832-46 pubmed publisher
    ..This budding involves phosphorylation of A-type lamin, a protein linked to muscular dystrophies. Thus nuclear envelope budding is an endogenous nuclear export pathway for large RNP granules.
  51. Domart M, Hobday T, Peddie C, Chung G, Wang A, Yeh K, et al. Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology. PLoS ONE. 2012;7:e51150 pubmed publisher
    ..Acute and inducible DAG depletion results in failure of the nuclear envelope (NE) to reform at mitosis and reorganisation of the ER into multi-lamellar sheets as revealed by correlative ..
  52. Solovei I, Wang A, Thanisch K, Schmidt C, Krebs S, Zwerger M, et al. LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell. 2013;152:584-98 pubmed publisher
    ..and species, including mice with mutations in the lamin B receptor (Lbr) and lamin A (Lmna) genes that encode nuclear envelope (NE) proteins. We identified LBR- and lamin-A/C-dependent mechanisms tethering heterochromatin to the NE...
  53. Clever M, Mimura Y, Funakoshi T, Imamoto N. Regulation and coordination of nuclear envelope and nuclear pore complex assembly. Nucleus. 2013;4:105-14 pubmed publisher
    ..with "open" mitosis, cells undergo structural changes involving the complete disassembly of the nuclear envelope (NE)...
  54. Yewdell W, Colombi P, Makhnevych T, Lusk C. Lumenal interactions in nuclear pore complex assembly and stability. Mol Biol Cell. 2011;22:1375-88 pubmed publisher
    Nuclear pore complexes (NPCs) provide a gateway for the selective transport of macromolecules across the nuclear envelope (NE)...
  55. Bolhy S, Bouhlel I, Dultz E, Nayak T, Zuccolo M, Gatti X, et al. A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase. J Cell Biol. 2011;192:855-71 pubmed publisher
    Centrosomes are closely associated with the nuclear envelope (NE) throughout the cell cycle and this association is maintained in prophase when they separate to establish the future mitotic spindle...
  56. Towbin B, Meister P, Pike B, Gasser S. Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner. Cold Spring Harb Symp Quant Biol. 2010;75:555-65 pubmed publisher
    ..Interestingly, depletion of nuclear lamina components caused release of arrays from the nuclear envelope and interfered with their efficient silencing...
  57. De Vos W, Houben F, Kamps M, Malhas A, Verheyen F, Cox J, et al. Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. Hum Mol Genet. 2011;20:4175-86 pubmed publisher
    ..Using live cell imaging, we observed the occurrence of intermittent, non-lethal ruptures of the nuclear envelope in dermal fibroblast cultures of patients with different mutations of lamin A/C...
  58. Mauger J. Role of the nuclear envelope in calcium signalling. Biol Cell. 2012;104:70-83 pubmed publisher
    ..The nuclear envelope (NE), which is continuous with the ER, has a double role: it insulates the nucleoplasm from the cytoplasm and ..
  59. Burns L, Wente S. Trafficking to uncharted territory of the nuclear envelope. Curr Opin Cell Biol. 2012;24:341-9 pubmed publisher
    The nuclear envelope (NE) in eukaryotic cells serves as the physical barrier between the nucleus and cytoplasm. Until recently, mechanisms for establishing the composition of the inner nuclear membrane (INM) remained uncharted...
  60. Gjerstorff M, Rösner H, Pedersen C, Greve K, Schmidt S, Wilson K, et al. GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). PLoS ONE. 2012;7:e45819 pubmed publisher
    ..GCL directly binds LEM-domain proteins (LAP2?, emerin, MAN1) at the nuclear envelope, and we found that GAGE proteins were recruited to the nuclear envelope inner membrane by GCL...
  61. Smoyer C, Jaspersen S. Breaking down the wall: the nuclear envelope during mitosis. Curr Opin Cell Biol. 2014;26:1-9 pubmed publisher
    A defining feature of eukaryotic cells is the nucleus, which houses the genome inside the nuclear envelope (NE): a double lipid bilayer that separates the nuclear and cytoplasmic materials...
  62. Olins A, Rhodes G, Welch D, Zwerger M, Olins D. Lamin B receptor: multi-tasking at the nuclear envelope. Nucleus. 2010;1:53-70 pubmed publisher
    Lamin B receptor (LBR) is an integral membrane protein of the interphase nuclear envelope (NE). The N-terminal end resides in the nucleoplasm, binding to lamin B and heterochromatin, with the interactions disrupted during mitosis...
  63. Liu G, Barkho B, Ruiz S, Diep D, Qu J, Yang S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011;472:221-5 pubmed publisher
    ..HGPS-iPSCs show absence of progerin, and more importantly, lack the nuclear envelope and epigenetic alterations normally associated with premature ageing...
  64. Terradas M, Martin M, Hernández L, Tusell L, Genesca A. Nuclear envelope defects impede a proper response to micronuclear DNA lesions. Mutat Res. 2012;729:35-40 pubmed publisher
  65. Malhas A, Vaux D. The nuclear envelope and its involvement in cellular stress responses. Biochem Soc Trans. 2011;39:1795-8 pubmed publisher
    The nuclear envelope is not only important for the structural integrity of the nucleus, but also involved in a number of cellular functions...
  66. Gerace L, Huber M. Nuclear lamina at the crossroads of the cytoplasm and nucleus. J Struct Biol. 2012;177:24-31 pubmed publisher
    The nuclear lamina is a protein meshwork that lines the nuclear envelope in metazoan cells...
  67. Schuster F, Klupp B, Granzow H, Mettenleiter T. Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34. J Virol. 2012;86:2079-88 pubmed publisher
    ..It is targeted to the nuclear envelope in the absence of other viral proteins, pointing to intrinsic localization motifs, and shows structural ..
  68. Rothballer A, Kutay U. The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin. Chromosoma. 2013;122:415-29 pubmed publisher
    The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes...
  69. Méjat A, Misteli T. LINC complexes in health and disease. Nucleus. 2010;1:40-52 pubmed publisher
    ..This review highlights the components of LINC complexes and their emerging roles in mechanotransduction, nuclear migration, chromosome positioning, signaling, meiosis, cytoskeletal organization and human disease. ..
  70. Capo Chichi C, Cai K, Simpkins F, Ganjei Azar P, Godwin A, Xu X. Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. BMC Med. 2011;9:28 pubmed publisher
    ..Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established...
  71. Meyer A, Almendrala D, Go M, Krauss S. Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling. J Cell Sci. 2011;124:1433-44 pubmed publisher
    ..4.1R localizes within nuclei, at the nuclear envelope, and in cytoplasm. Here we show that 4...
  72. Aoki K, Hayashi H, Furuya K, Sato M, Takagi T, Osumi M, et al. Breakage of the nuclear envelope by an extending mitotic nucleus occurs during anaphase in Schizosaccharomyces japonicus. Genes Cells. 2011;16:911-26 pubmed publisher
    During open mitosis in higher eukaryotic cells, the nuclear envelope completely breaks down and then mitotic chromosomes are exposed in the cytoplasm...
  73. Yam C, He Y, Zhang D, Chiam K, Oliferenko S. Divergent strategies for controlling the nuclear membrane satisfy geometric constraints during nuclear division. Curr Biol. 2011;21:1314-9 pubmed publisher
    ..We propose that scaling considerations could have shaped the evolution of eukaryotic mitosis by necessitating either nuclear surface expansion or the NE breakdown...
  74. Vagnarelli P, Ribeiro S, Sennels L, Sanchez Pulido L, de Lima Alves F, Verheyen T, et al. Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell. 2011;21:328-42 pubmed publisher
    ..These observations identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit.
  75. Chikashige Y, Haraguchi T, Hiraoka Y. Nuclear envelope attachment is not necessary for telomere function in fission yeast. Nucleus. 2010;1:481-6 pubmed publisher
    ..Telomeres are the most obvious chromosomal sites that are anchored to the nuclear envelope in this organism...
  76. Gonzalez J, Andres V. Synthesis, transport and incorporation into the nuclear envelope of A-type lamins and inner nuclear membrane proteins. Biochem Soc Trans. 2011;39:1758-63 pubmed publisher
    The mammalian NE (nuclear envelope), which separates the nucleus from the cytoplasm, is a complex structure composed of nuclear pore complexes, the outer and inner nuclear membranes, the perinuclear space and the nuclear lamina (A- and B-..
  77. Habermann K, Mirgorodskaya E, Gobom J, Lehmann V, Müller H, Blümlein K, et al. Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression. Mol Cell Biol. 2012;32:3554-69 pubmed publisher
    ..Using a combinatorial RNA interference (RNAi) strategy, we demonstrated novel functions for P granule, nuclear envelope (NE), and nuclear proteins in centrosome duplication, maturation, and separation...
  78. Jokhi V, Ashley J, Nunnari J, Noma A, Ito N, Wakabayashi Ito N, et al. Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope. Cell Rep. 2013;3:988-95 pubmed publisher
    ..mechanism through which large ribonucleoprotein (megaRNP) granules exit the nucleus is by budding through the nuclear envelope (NE)...
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    ..HeLa cells causes defects in cell division and a proliferation of intranuclear membranes derived from the nuclear envelope. This phenotype originates in mitosis, when ER membranes accumulate on metaphase chromosomes...
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    ..Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope with the help of soluble transport receptors...
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    Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease...
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    ..We propose an import mechanism for membrane proteins in which an unfolded linker slices through the NPC scaffold to enable binding between the transport factor and the FG domains in the center of the NPC...
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    ..DMPK is a nuclear envelope (NE) protein that promotes myogenic gene expression in skeletal myoblasts...
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    ..depend on pairing centers (PCs), special regions near one end of each chromosome that interact with the nuclear envelope (NE) and cytoplasmic microtubules...
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    ..Collectively, these data support a model whereby emerin facilitates repressive chromatin formation at the nuclear periphery by increasing the catalytic activity of HDAC3...
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    One hypothesis to explain how mutations in the same nuclear envelope proteins yield pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners mediate the disease pathologies...
  87. Horn H, Brownstein Z, Lenz D, Shivatzki S, Dror A, Dagan Rosenfeld O, et al. The LINC complex is essential for hearing. J Clin Invest. 2013;123:740-50 pubmed publisher
    ..inner nuclear membrane (INM), are part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. Mice lacking either Nesp4 or Sun1 were evaluated for hair cell defects and hearing loss...
  88. Alvarez Fernandez M, Sánchez Martínez R, Sanz Castillo B, Gan P, Sanz Flores M, Trakala M, et al. Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals. Proc Natl Acad Sci U S A. 2013;110:17374-9 pubmed publisher
    ..However, these cells display mitotic collapse after nuclear envelope breakdown (NEB) characterized by defective chromosome condensation and prometaphase arrest...
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    The nuclear envelope contains >100 transmembrane proteins that continuously exchange with the endoplasmic reticulum and move within the nuclear membranes...
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    ..It has remained unresolved, however, whether the association of facultative heterochromatin with the nuclear periphery, or its release, has functional relevance for cell or tissue integrity...
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    In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years...
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    ..Recent studies have identified many components of the nuclear envelope in living Opisthokonts, the eukaryotic supergroup that includes fungi and metazoan animals...