adherens junctions

Summary

Summary: Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.

Top Publications

  1. Taguchi K, Ishiuchi T, Takeichi M. Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping. J Cell Biol. 2011;194:643-56 pubmed publisher
    ..These findings suggest that epithelial cells remodel their junctional architecture by responding to mechanical forces, and the ?E-catenin-bound EPLIN acts as a mechanosensitive regulator for this process. ..
  2. Guntur A, Rosen C, Naski M. N-cadherin adherens junctions mediate osteogenesis through PI3K signaling. Bone. 2012;50:54-62 pubmed publisher
    ..Communication between osteoblasts in the perichondrium via N-cadherin adherens junctions is essential for endochondral bone growth...
  3. Kovacs E, Verma S, Ali R, Ratheesh A, Hamilton N, Akhmanova A, et al. N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. Nat Cell Biol. 2011;13:934-43 pubmed publisher
    ..We conclude that N-WASP-WIRE serves as an integrator that couples actin nucleation with the subsequent steps of filament stabilization and organization necessary for zonula adherens integrity. ..
  4. Yamamoto H, Maruo T, Majima T, Ishizaki H, Tanaka Okamoto M, Miyoshi J, et al. Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain. PLoS ONE. 2013;8:e80356 pubmed publisher
    b>Adherens junctions (AJs) play a role in mechanically connecting adjacent cells to maintain tissue structure, particularly in epithelial cells. The major cell-cell adhesion molecules at AJs are cadherins and nectins...
  5. Mangold S, Wu S, Norwood S, Collins B, Hamilton N, Thorn P, et al. Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens. Curr Biol. 2011;21:503-7 pubmed publisher
    ..We conclude that regulators of the junctional cytoskeleton are likely to be major targets for cadherin junctions to be acutely modulated in development and perturbed in disease. ..
  6. Hatanaka K, Lanahan A, Murakami M, Simons M. Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. PLoS ONE. 2012;7:e37600 pubmed publisher
    ..plays a critical role in the maintenance of vascular integrity via enhancing the stability of VE-cadherin at adherens junctions. However, the precise molecular mechanism is not well understood...
  7. Yonemura S. Cadherin-actin interactions at adherens junctions. Curr Opin Cell Biol. 2011;23:515-22 pubmed publisher
    ..Here, I provide an overview of cadherin-actin interaction from morphological aspects and of possible molecular mechanisms revealed by recent studies...
  8. Birukova A, Fu P, Wu T, Dubrovskyi O, Sarich N, Poroyko V, et al. Afadin controls p120-catenin-ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids. J Cell Physiol. 2012;227:1883-90 pubmed publisher
    ..This study examined a role of afadin in the OxPAPC-induced enhancement of interactions between adherens junctions and tight junctions as a novel mechanism of endothelial cell (EC) barrier preservation...
  9. Sawyer J, Choi W, Jung K, He L, Harris N, Peifer M. A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Mol Biol Cell. 2011;22:2491-508 pubmed publisher
    ..We propose a model in which an actomyosin network linked at AP AJs by Canoe and coupled to apical polarity proteins regulates convergent extension. ..

More Information

Publications85

  1. Takeichi M. Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling. Nat Rev Mol Cell Biol. 2014;15:397-410 pubmed publisher
    ..Accumulating evidence suggests that the remodelling of cell junctions, especially adherens junctions (AJs), has major roles in controlling these behaviours...
  2. Michel M, Raabe I, Kupinski A, Pérez Palencia R, Bökel C. Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche. Nat Commun. 2011;2:415 pubmed publisher
    ..spatial specificity of niche signals is maximized by subcellularly restricting signalling to cadherin-based adherens junctions between individual niche and stem cells...
  3. Thibeault S, Rautureau Y, Oubaha M, Faubert D, Wilkes B, Delisle C, et al. S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability. Mol Cell. 2010;39:468-76 pubmed publisher
    Disruption of adherens junctions between endothelial cells results in compromised endothelial barrier function and in altered angiogenesis...
  4. Letizia A, Llimargas M. Adherens junctions and cadherins in Drosophila development. Subcell Biochem. 2012;60:251-77 pubmed publisher
    ..molecular and genetic mechanisms of development and is an ideal model system to study the contribution of Adherens Junctions (AJs) and their major components, cadherins, to morphogenesis...
  5. Kasai S, Ishigaki T, Takumi R, Kamimura T, Kikuchi H. Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. Biochim Biophys Acta. 2013;1830:2509-16 pubmed
    ..human colon carcinoma cells by transfer to Minimal Essential Medium (Spinner Modification; S-MEM) destroyed adherens junctions and the cells were used as the model of wound-healing process...
  6. Chen G, Rogers A, League G, Nam S. Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. PLoS ONE. 2011;6:e16127 pubmed publisher
    ..Cnn overexpression in photoreceptors caused the expansion of the apical Crb membrane domain, Baz and adherens junctions (AJs)...
  7. Naydenov N, Brown B, Harris G, Dohn M, Morales V, Baranwal S, et al. A membrane fusion protein ?SNAP is a novel regulator of epithelial apical junctions. PLoS ONE. 2012;7:e34320 pubmed publisher
    Tight junctions (TJs) and adherens junctions (AJs) are key determinants of the structure and permeability of epithelial barriers...
  8. Ayollo D, Zhitnyak I, Vasiliev J, Gloushankova N. Rearrangements of the actin cytoskeleton and E-cadherin-based adherens junctions caused by neoplasic transformation change cell-cell interactions. PLoS ONE. 2009;4:e8027 pubmed publisher
    ..which is typical of nontransformed IAR-2 cells, disappeared, and the continuous adhesion belt (tangential adherens junctions (AJs)) was replaced by radially oriented E-cadherin-based AJs...
  9. Tripathi V, Popescu N, Zimonjic D. DLC1 interaction with ?-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity. Mol Cell Biol. 2012;32:2145-59 pubmed publisher
    ..a RhoGAP protein that inactivates Rho GTPases, which are implicated in regulation of the cytoskeleton and adherens junctions (AJs), a cell-cell adhesion protein complex associated with the actin cytoskeleton...
  10. Boggetti B, Niessen C. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice. Subcell Biochem. 2012;60:321-55 pubmed publisher
    ..of mice mutations, either germ line, conditional or inducible, have been generated in the past years for adherens junctions components, and the number is still increasing...
  11. Palatinus J, O Quinn M, Barker R, Harris B, Jourdan J, Gourdie R. ZO-1 determines adherens and gap junction localization at intercalated disks. Am J Physiol Heart Circ Physiol. 2011;300:H583-94 pubmed publisher
    ..evidence is provided that zonula occludens-1 (ZO-1) regulates the organization of gap junctions (GJs) and adherens junctions (AJs) at ICDs...
  12. Young J, Takai Y, Kojic K, Vogl A. Internalization of adhesion junction proteins and their association with recycling endosome marker proteins in rat seminiferous epithelium. Reproduction. 2012;143:347-57 pubmed publisher
  13. Franke W, Rickelt S. Mesenchymal-epithelial transitions: spontaneous and cumulative syntheses of epithelial marker molecules and their assemblies to novel cell junctions connecting human hematopoietic tumor cells to carcinomatoid tissue structures. Int J Cancer. 2011;129:2588-99 pubmed publisher
    ..We discuss molecular mechanisms involved in the formation and function of these junctions, also with respect to tumor spread and metastasis, as well as diagnostic and therapeutic consequences...
  14. Yoshihara K, Ikenouchi J, Izumi Y, Akashi M, Tsukita S, Furuse M. Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes. Exp Cell Res. 2011;317:413-22 pubmed publisher
    ..In this study, we investigated the relationship between the localization of mouse Scribble at cadherin-based adherens junctions (AJs) and its phosphorylation state...
  15. Samak G, Aggarwal S, Rao R. ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers. Am J Physiol Gastrointest Liver Physiol. 2011;301:G50-9 pubmed publisher
    ..results indicate that EGF-mediated protection of tight junctions from acetaldehyde requires the activity of ERK1/2, but not p38 MAPK or JNK1/2, and that EGF-mediated protection of adherens junctions is independent of MAPK activities.
  16. Sumigray K, Foote H, Lechler T. Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. J Cell Biol. 2012;199:513-25 pubmed publisher
    ..assay, we show that cortical microtubules recruit myosin II to the cell cortex in order to engage adherens junctions, resulting in an increase in mechanical integrity of the cell sheets...
  17. Straub B, Rickelt S, Zimbelmann R, Grund C, Kuhn C, Iken M, et al. E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells. J Cell Biol. 2011;195:873-87 pubmed publisher
    ..In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis...
  18. O Connor P, Lapointe T, Jackson S, Beck P, Jones N, Buret A. Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect Immun. 2011;79:3887-94 pubmed publisher
    ..H. pylori-induced disruption of epithelial adherens junctions (AJs) is thought to promote the development of severe disease; however, the mechanisms whereby H...
  19. Nanes B, Chiasson MacKenzie C, Lowery A, Ishiyama N, Faundez V, Ikura M, et al. p120-catenin binding masks an endocytic signal conserved in classical cadherins. J Cell Biol. 2012;199:365-80 pubmed publisher
    ..These results reveal the mechanistic basis by which p120 stabilizes cadherins and demonstrate that VE-cadherin endocytosis is crucial for endothelial cell migration in response to an angiogenic growth factor...
  20. Morais de Sá E, Sunkel C. Adherens junctions determine the apical position of the midbody during follicular epithelial cell division. EMBO Rep. 2013;14:696-703 pubmed publisher
    ..We show that adherens junctions (AJs) maintain close contact with the apical side of the contractile ring during cytokinesis...
  21. Tang V, Brieher W. ?-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol. 2012;196:115-30 pubmed publisher
    ..These findings demonstrate that ?-actinin-4 plays an important role in coupling actin nucleation to assembly at cadherin-based cell-cell adhesive contacts...
  22. Kowalczyk A, Nanes B. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling. Subcell Biochem. 2012;60:197-222 pubmed publisher
    b>Adherens junctions are important mediators of intercellular adhesion, but they are not static structures...
  23. Troyanovsky S. Adherens junction assembly. Subcell Biochem. 2012;60:89-108 pubmed publisher
    Classical cadherins are a family of transmembrane proteins that mediate cell-cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster...
  24. Nikitas G, Cossart P. Adherens junctions and pathogen entry. Subcell Biochem. 2012;60:415-25 pubmed publisher
    ..and maintenance is mediated by cell-cell adhesion molecules organised in junctional complexes, such as the adherens junctions. The tight organisation of these complexes and their interactions with cellular factors render the epithelia ..
  25. Rickelt S, Moll I, Franke W. Intercellular adhering junctions with an asymmetric molecular composition: desmosomes connecting Merkel cells and keratinocytes. Cell Tissue Res. 2011;346:65-77 pubmed publisher
    ..We discuss the developmental, tissue-architectonic and functional importance of such asymmetric junctions in normal physiology as well as in diseases, in particular in the formation of distant tumor cell metastasis...
  26. Johnson R, Sedgwick A, D SOUZA SCHOREY C, Cagan R. Role for a Cindr-Arf6 axis in patterning emerging epithelia. Mol Biol Cell. 2011;22:4513-26 pubmed publisher
    ..We propose that a Neph1/nephrin-Cindr/ArfGAP complex accumulates to limit local Arf6 activity and stabilize adherens junctions. Our model therefore links surface adhesion via an Arf6 regulatory cascade to dynamic modeling of the ..
  27. Lee M, Padmashali R, Koria P, Andreadis S. JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion. FASEB J. 2011;25:613-23 pubmed publisher
    We recently reported that c-Jun N-terminal kinase (JNK) is associated with adherens junctions and phosphorylates ?-catenin at serine 33/37 and threonine 41...
  28. Katayama K, Melendez J, Baumann J, Leslie J, Chauhan B, Nemkul N, et al. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A. 2011;108:7607-12 pubmed publisher
    ..The organization of neural progenitors in the developing mammalian neuroepithelium is marked by cadherin-based adherens junctions. Whereas RhoA, a founding member of the small Rho GTPase family, has been shown to play important roles in ..
  29. Ishiyama N, Tanaka N, Abe K, Yang Y, Abbas Y, Umitsu M, et al. An autoinhibited structure of ?-catenin and its implications for vinculin recruitment to adherens junctions. J Biol Chem. 2013;288:15913-25 pubmed publisher
    ..catenin, but the mechanisms by which it anchors the cadherin-catenin complex to the actin cytoskeleton at adherens junctions remain unclear...
  30. Harrison O, Jin X, Hong S, Bahna F, Ahlsen G, Brasch J, et al. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure. 2011;19:244-56 pubmed publisher
    b>Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains extended from opposing cell surfaces...
  31. Maiers J, Peng X, Fanning A, DeMali K. ZO-1 recruitment to ?-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions. J Cell Sci. 2013;126:3904-15 pubmed publisher
    ..the tight junction barrier is dependent upon neighboring epithelial cells binding to one another and forming adherens junctions, but the mechanism for how these processes are linked is poorly understood...
  32. Chanson L, Brownfield D, Garbe J, Kuhn I, Stampfer M, Bissell M, et al. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. Proc Natl Acad Sci U S A. 2011;108:3264-9 pubmed publisher
    ..Together these data show that self-organization is an innate and reversible property of communities of normal adult human mammary epithelial cells...
  33. Baum B, Georgiou M. Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. J Cell Biol. 2011;192:907-17 pubmed publisher
    ..This turnover contributes to junction formation and to the maintenance of epithelial integrity during tissue homeostasis and remodeling...
  34. Dusek R, Attardi L. Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer. 2011;11:317-23 pubmed publisher
    b>Adherens junctions, which are intercellular adhesive complexes that are crucial for maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour progression...
  35. Komarova Y, Huang F, Geyer M, Daneshjou N, Garcia A, Idalino L, et al. VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions. Mol Cell. 2012;48:914-25 pubmed publisher
    ..endothelial (VE)-cadherin homophilic adhesion controls endothelial barrier permeability through assembly of adherens junctions (AJs)...
  36. Levayer R, Pelissier Monier A, Lecuit T. Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. Nat Cell Biol. 2011;13:529-40 pubmed publisher
    ..Finally, we provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin...
  37. Hong S, Troyanovsky R, Troyanovsky S. Binding to F-actin guides cadherin cluster assembly, stability, and movement. J Cell Biol. 2013;201:131-43 pubmed publisher
    ..Such cooperation apparently synchronizes extracellular and intracellular binding events in the process of adherens junction assembly...
  38. Fernández Martín L, Marcos Ramiro B, Bigarella C, Graupera M, Cain R, Reglero Real N, et al. Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol. 2012;32:e90-102 pubmed publisher
    ..b>Adherens junctions (AJ) play a central role in regulating this barrier...
  39. Etienne Manneville S. Adherens junctions during cell migration. Subcell Biochem. 2012;60:225-49 pubmed publisher
    ..Cadherin and nectin-based adherens junctions are key players in intercellular interactions...
  40. Shahbazi M, Megias D, Epifano C, Akhmanova A, Gundersen G, Fuchs E, et al. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. J Cell Biol. 2013;203:1043-61 pubmed publisher
    ..In this paper, we report that the MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes...
  41. Krishnan S, Fernandez G, Sacks D, Prasadarao N. IQGAP1 mediates the disruption of adherens junctions to promote Escherichia coli K1 invasion of brain endothelial cells. Cell Microbiol. 2012;14:1415-33 pubmed publisher
    ..Subsequently, IQGAP1/?-catenin bound actin translocates to the site of E.?coli K1 attachment to promote invasion...
  42. Chartier N, Lainé M, Ducarouge B, Oddou C, Bonaz B, Albiges Rizo C, et al. Enterocytic differentiation is modulated by lipid rafts-dependent assembly of adherens junctions. Exp Cell Res. 2011;317:1422-36 pubmed publisher
    ..This study investigated potential mechanisms by which LR could participate in the establishment of adherens junctions (AJ) and the initiation of enterocytic differentiation...
  43. Fernandez Gonzalez R, Zallen J. Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. Phys Biol. 2011;8:045005 pubmed publisher
    ..We discuss models to explain how the architecture of cytoskeletal networks regulates their contractile behavior and the mechanisms that give rise to oscillatory cell behaviors in intercalating cells...
  44. Haidari M, Zhang W, Chen Z, Ganjehei L, Warier N, Vanderslice P, et al. Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctions. Cardiovasc Res. 2011;92:456-65 pubmed publisher
    ..phosphorylation of vascular endothelial cadherin (VE-cad) has been implicated in the dissociation of adherens junctions and the increased paracellular permeability of endothelial cells (ECs) that occur during TEM of monocytes...
  45. Pieperhoff S, Rickelt S, Heid H, Claycomb W, Zimbelmann R, Kuhn C, et al. The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems. J Cell Mol Med. 2012;16:1709-19 pubmed publisher
    ..specific antibodies we now report that myozap is also a major constituent of the cytoplasmic plaques of the adherens junctions (AJs) connecting the endothelial cells of the mammalian blood and lymph vascular systems, including the ..
  46. Ivanov A, Naydenov N. Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies. Int Rev Cell Mol Biol. 2013;303:27-99 pubmed publisher
    b>Adherens junctions (AJs) are evolutionarily conserved plasma-membrane structures that mediate cell-cell adhesions in multicellular organisms...
  47. Timmerman I, Hoogenboezem M, Bennett A, Geerts D, Hordijk P, van Buul J. The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of ?-catenin phosphorylation. Mol Biol Cell. 2012;23:4212-25 pubmed publisher
    ..Repair of a dysfunctional endothelial barrier requires controlled restoration of adherens junctions, comprising vascular endothelial (VE)-cadherin and associated ?-, ?-, ?-, and p120-catenins...
  48. McKinley R, Harris T. Displacement of basolateral Bazooka/PAR-3 by regulated transport and dispersion during epithelial polarization in Drosophila. Mol Biol Cell. 2012;23:4465-71 pubmed publisher
    ..Our work complements recent findings in Caenorhabditis elegans and thus suggests the coupling of transport and dispersion is a common protein polarization strategy...
  49. Verma S, Han S, Michael M, Gomez G, Yang Z, Teasdale R, et al. A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell. 2012;23:4601-10 pubmed publisher
    ..WAVE2-Arp2/3 disruption depleted junctions of both myosin IIA and IIB, suggesting that dynamic actin assembly may support junctional tension by facilitating the local recruitment of myosin...
  50. Ratheesh A, Gomez G, Priya R, Verma S, Kovacs E, Jiang K, et al. Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol. 2012;14:818-828 pubmed publisher
    ..Thus, a conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens. ..
  51. Peng Y, Lin Y, Chen Y, Hung K, Wang S. Effects of indoxyl sulfate on adherens junctions of endothelial cells and the underlying signaling mechanism. J Cell Biochem. 2012;113:1034-43 pubmed publisher
    ..This study explored the effects of IS on the adherens junctions of vascular endothelial cells and revealed the underlying mechanism...
  52. Rangarajan E, Izard T. Dimer asymmetry defines ?-catenin interactions. Nat Struct Mol Biol. 2013;20:188-93 pubmed publisher
    ..whereas interactions of ?-catenin with the cytoskeletal protein vinculin appear to be necessary to stabilize adherens junctions. Here we report the crystal structure of nearly full-length human ?-catenin at 3.7-Å resolution...
  53. Nishimura T, Honda H, Takeichi M. Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012;149:1084-97 pubmed publisher
    ..In the bending neural plates, we find that a PCP-regulating cadherin, Celsr1, is concentrated in adherens junctions (AJs) oriented toward the mediolateral axes of the plates...
  54. Birukova A, Zebda N, Fu P, Poroyko V, Cokic I, Birukov K. Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids. J Cell Physiol. 2011;226:2052-62 pubmed publisher
    ..This study examined a role of Rap1 in regulation of OxPAPC-induced interactions in adherens junctions (AJ) and tight junctions (TJ) as a novel mechanism of EC barrier preservation in vitro and in vivo...
  55. Huang J, Huang L, Chen Y, Austin E, Devor C, Roegiers F, et al. Differential regulation of adherens junction dynamics during apical-basal polarization. J Cell Sci. 2011;124:4001-13 pubmed publisher
    b>Adherens junctions (AJs) in epithelial cells are constantly turning over to modulate adhesion properties under various physiological and developmental contexts, but how such AJ dynamics are regulated during the apical-basal polarization ..
  56. St Johnston D, Sanson B. Epithelial polarity and morphogenesis. Curr Opin Cell Biol. 2011;23:540-6 pubmed publisher
    ..By affecting the contractility of the actomyosin cytoskeleton and the stability of adherens junctions, changes within the plane of the epithelium can cause cell rearrangements that contribute to convergence and ..
  57. Lee D, Kang D, Choi M, Choi Y, Lee J, Park J, et al. Peroxiredoxin-2 represses melanoma metastasis by increasing E-Cadherin/?-Catenin complexes in adherens junctions. Cancer Res. 2013;73:4744-57 pubmed publisher
    ..investigations indicated that Prx2 negatively regulated Src/ERK activation status, which in turn fortified adherens junctions function by increasing E-cadherin expression and phospho-Y654-dependent retention of ?-catenin in the plasma ..
  58. Wang Y, Khan Z, Kaschube M, Wieschaus E. Differential positioning of adherens junctions is associated with initiation of epithelial folding. Nature. 2012;484:390-3 pubmed publisher
    ..Here we describe an alternative mechanism that requires differential positioning of adherens junctions controlled by modulation of epithelial apical-basal polarity...
  59. Rickelt S, Kuhn C, Winter Simanowski S, Zimbelmann R, Frey N, Franke W. Protein myozap--a late addition to the molecular ensembles of various kinds of adherens junctions. Cell Tissue Res. 2011;346:347-59 pubmed publisher
    ..plaques of the composite junctions (areae compositae) in the myocardiac intercalated disks and of the adherens junctions (AJs) in vascular endothelia...
  60. Vasioukhin V. Adherens junctions and cancer. Subcell Biochem. 2012;60:379-414 pubmed publisher
    Cadherins and catenins are the central cell-cell adhesion molecules in adherens junctions (AJs)...
  61. Boissan M, De Wever O, Lizarraga F, Wendum D, Poincloux R, Chignard N, et al. Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. Cancer Res. 2010;70:7710-22 pubmed publisher
  62. Robertson F, Pinal N, Fichelson P, Pichaud F. Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. Development. 2012;139:3432-41 pubmed publisher
    ..It also sheds new light on the interplay between Ato, EGFR-dependent transcription and AJ remodelling in a system in which neurogenesis is coupled with cell shape changes and regulated steps of cell intercalation...
  63. Mathew S, Rembold M, Leptin M. Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mol Cell Biol. 2011;31:4978-93 pubmed publisher
    ..that internalize the mesoderm are controlled by the transcription factor Twist and require intact adherens junctions and a contractile acto-myosin network...
  64. Naydenov N, Ivanov A. Adducins regulate remodeling of apical junctions in human epithelial cells. Mol Biol Cell. 2010;21:3506-17 pubmed publisher
    Epithelial adherens junctions (AJs) and tight junctions (TJs) are dynamic structures that readily undergo disintegration and reassembly...
  65. Armenti S, Nance J. Adherens junctions in C. elegans embryonic morphogenesis. Subcell Biochem. 2012;60:279-99 pubmed publisher
    Caenorhabditis elegans provides a simplified, in vivo model system in which to study adherens junctions (AJs) and their role in morphogenesis...
  66. Wickline E, Du Y, Stolz D, Kahn M, Monga S. ?-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after ?-catenin knockdown. Neoplasia. 2013;15:421-34 pubmed
    Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC)...
  67. Fang W, Liao L, Li L, Xie Y, Xu X, Zhao W, et al. Down-regulated desmocollin-2 promotes cell aggressiveness through redistributing adherens junctions and activating beta-catenin signalling in oesophageal squamous cell carcinoma. J Pathol. 2013;231:257-70 pubmed publisher
    In contrast to the well-recognized loss of adherens junctions in cancer progression, the role of desmosomal components in cancer development has not been well explored...
  68. Ting L, Jahn J, Jung J, Shuman B, Feghhi S, Han S, et al. Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions. Am J Physiol Heart Circ Physiol. 2012;302:H2220-9 pubmed publisher
    ..The response in adhesion junction assembly matched closely with changes in traction forces since adherens junctions were larger in size for laminar flow and smaller for disturbed flow...
  69. Smutny M, Wu S, Gomez G, Mangold S, Yap A, Hamilton N. Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens. PLoS ONE. 2011;6:e22458 pubmed publisher
    ..This extends our recent analysis of Myosin II at the ZA to demonstrate that Myosin IIA and Myosin IIB make distinct contributions to junctional movement at the ZA...
  70. McLachlan R, Yap A. Protein tyrosine phosphatase activity is necessary for E-cadherin-activated Src signaling. Cytoskeleton (Hoboken). 2011;68:32-43 pubmed publisher
    ..We conclude that PTP-activated Src signaling is a possible upstream regulator of myosin IIB at the epithelial zonula adherens...
  71. Haidari M, Zhang W, Chen Z, Ganjehei L, Mortazavi A, Warier N, et al. Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation. Exp Cell Res. 2012;318:1673-84 pubmed publisher
    ..Vascular endothelial cadherin (VE-cad) tyrosine (Tyr) phosphorylation has been implicated in the disruption of adherens junctions (AJs) induced by inflammatory reactions...
  72. Livshits G, Kobielak A, Fuchs E. Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis. Proc Natl Acad Sci U S A. 2012;109:4886-91 pubmed publisher
    ..The increased dependency of cells upon matrix interactions for their survival when cell-cell adhesions are destabilized has important implications for cancer progression and metastasis...
  73. Barth M, Rickelt S, Noffz E, Winter Simanowski S, Niemann H, Akhyari P, et al. The adhering junctions of valvular interstitial cells: molecular composition in fetal and adult hearts and the comings and goings of plakophilin-2 in situ, in cell culture and upon re-association with scaffolds. Cell Tissue Res. 2012;348:295-307 pubmed publisher
    ..four mammalian species examined (human, bovine, porcine and ovine), the typical mesenchymal-type cell-cell adherens junctions (AJs) connecting VICs appear as normal N-cadherin based puncta adhaerentia...
  74. Rickelt S. Plakophilin-2: a cell-cell adhesion plaque molecule of selective and fundamental importance in cardiac functions and tumor cell growth. Cell Tissue Res. 2012;348:281-94 pubmed publisher
    ..Possible functions and assembly mechanisms of such Pkp2-positive cell-cell junctions as well as medical consequences are discussed...
  75. Hong S, Troyanovsky R, Troyanovsky S. Cadherin exits the junction by switching its adhesive bond. J Cell Biol. 2011;192:1073-83 pubmed publisher
    ..interfaces, the so-called strand-swap and X dimer interfaces of E-cadherin, in the dynamic remodeling of adherens junctions using photoactivation, calcium switch, and coimmunoprecipitation assays...
  76. Vandenbroucke St Amant E, Tauseef M, Vogel S, Gao X, Mehta D, Komarova Y, et al. PKC? activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity. Circ Res. 2012;111:739-49 pubmed publisher
    b>Adherens junctions (AJs) are the primary intercellular junctions in microvessels responsible for endothelial barrier function...