intercellular junctions

Summary

Summary: Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)

Top Publications

  1. Shivanna M, Srinivas S. Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium. Mol Vis. 2010;16:1781-90 pubmed
    ..This study investigates whether elevated cAMP is effective against the tumor necrosis factor-alpha (TNF-alpha)-induced loss of barrier integrity in monolayers of bovine corneal endothelial cells (BCEC)...
  2. Simpson C, Patel D, Green K. Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol. 2011;12:565-80 pubmed publisher
    ..These architectural components are more than just rivets and scaffolds - they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation...
  3. Ishiuchi T, Takeichi M. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nat Cell Biol. 2011;13:860-6 pubmed publisher
    ..Thus, we have uncovered a Willin/Par3-aPKC-ROCK pathway that controls epithelial apical morphology...
  4. Spindler V, Peter D, Harms G, Asan E, Waschke J. Ultrastructural analysis reveals cAMP-dependent enhancement of microvascular endothelial barrier functions via Rac1-mediated reorganization of intercellular junctions. Am J Pathol. 2011;178:2424-36 pubmed publisher
    ..were closely apposed over comparatively long distances; in addition, they were stabilized by numerous intercellular junctions. Interference with Rac1 activation by NSC-23766 completely abolished both barrier stabilization and ..
  5. Saarikangas J, Mattila P, Varjosalo M, Bovellan M, Hakanen J, Calzada Wack J, et al. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2011;124:1245-55 pubmed publisher
    ..mice displayed a severe urinary concentration defect caused by compromised integrity of kidney epithelia intercellular junctions, which led to bone abnormalities and end-stage renal failure...
  6. Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, et al. RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell. 2011;22:593-605 pubmed publisher
    ..Our data indicate a crucial role for RhoA and contraction in regulating cell spreading and a contraction-independent function of RhoA in keratinocyte migration. In addition, our data show that RhoA is dispensable for skin development...
  7. Mirza M, Pang M, Zaini M, Haiko P, Tammela T, Alitalo K, et al. Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. PLoS ONE. 2012;7:e37523 pubmed publisher
    ..The results show that CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions...
  8. Lie P, Cheng C, Mruk D. The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol. 2011;286:223-69 pubmed publisher
    ..We place special emphasis on the emerging role of desmosome-like junctions as signal transducers during germ cell movement across the seminiferous epithelium...
  9. Hashimoto K, Kataoka N, Nakamura E, Hagihara K, Hatano M, Okamoto T, et al. Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions. Int J Cardiol. 2011;149:232-9 pubmed publisher
    ..In this study, we tested the hypothesis that monocyte transmigration alters endothelial junctional organization to facilitate subsequent transmigration...
  10. Burns J, Collado M, Oliver E, Corwin J. Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes. J Comp Neurol. 2013;521:1430-48 pubmed publisher
    ..The presence of webs of F-actin at the junctions in Anolis appears compatible with supporting cell proliferation, but the solid reinforcement of the F-actin belts in mammals is associated with its absence...

Detail Information

Publications70

  1. Shivanna M, Srinivas S. Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium. Mol Vis. 2010;16:1781-90 pubmed
    ..This study investigates whether elevated cAMP is effective against the tumor necrosis factor-alpha (TNF-alpha)-induced loss of barrier integrity in monolayers of bovine corneal endothelial cells (BCEC)...
  2. Simpson C, Patel D, Green K. Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol. 2011;12:565-80 pubmed publisher
    ..These architectural components are more than just rivets and scaffolds - they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation...
  3. Ishiuchi T, Takeichi M. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nat Cell Biol. 2011;13:860-6 pubmed publisher
    ..Thus, we have uncovered a Willin/Par3-aPKC-ROCK pathway that controls epithelial apical morphology...
  4. Spindler V, Peter D, Harms G, Asan E, Waschke J. Ultrastructural analysis reveals cAMP-dependent enhancement of microvascular endothelial barrier functions via Rac1-mediated reorganization of intercellular junctions. Am J Pathol. 2011;178:2424-36 pubmed publisher
    ..were closely apposed over comparatively long distances; in addition, they were stabilized by numerous intercellular junctions. Interference with Rac1 activation by NSC-23766 completely abolished both barrier stabilization and ..
  5. Saarikangas J, Mattila P, Varjosalo M, Bovellan M, Hakanen J, Calzada Wack J, et al. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2011;124:1245-55 pubmed publisher
    ..mice displayed a severe urinary concentration defect caused by compromised integrity of kidney epithelia intercellular junctions, which led to bone abnormalities and end-stage renal failure...
  6. Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, et al. RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell. 2011;22:593-605 pubmed publisher
    ..Our data indicate a crucial role for RhoA and contraction in regulating cell spreading and a contraction-independent function of RhoA in keratinocyte migration. In addition, our data show that RhoA is dispensable for skin development...
  7. Mirza M, Pang M, Zaini M, Haiko P, Tammela T, Alitalo K, et al. Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. PLoS ONE. 2012;7:e37523 pubmed publisher
    ..The results show that CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions...
  8. Lie P, Cheng C, Mruk D. The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol. 2011;286:223-69 pubmed publisher
    ..We place special emphasis on the emerging role of desmosome-like junctions as signal transducers during germ cell movement across the seminiferous epithelium...
  9. Hashimoto K, Kataoka N, Nakamura E, Hagihara K, Hatano M, Okamoto T, et al. Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions. Int J Cardiol. 2011;149:232-9 pubmed publisher
    ..In this study, we tested the hypothesis that monocyte transmigration alters endothelial junctional organization to facilitate subsequent transmigration...
  10. Burns J, Collado M, Oliver E, Corwin J. Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes. J Comp Neurol. 2013;521:1430-48 pubmed publisher
    ..The presence of webs of F-actin at the junctions in Anolis appears compatible with supporting cell proliferation, but the solid reinforcement of the F-actin belts in mammals is associated with its absence...
  11. Hoelzle M, Svitkina T. The cytoskeletal mechanisms of cell-cell junction formation in endothelial cells. Mol Biol Cell. 2012;23:310-23 pubmed publisher
    ..Moreover, a novel lamellipodia-to-filopodia transition is used in this context...
  12. Herwig L, Blum Y, Krudewig A, Ellertsdottir E, Lenard A, Belting H, et al. Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo. Curr Biol. 2011;21:1942-8 pubmed publisher
    ..Here, the invaginating inner cell membrane undergoes concomitant apicobasal polarization and the vascular lumen is formed by the extension of a transcellular lumen through the EC, which forms a unicellular or seamless tube...
  13. Franke W, Rickelt S. Mesenchymal-epithelial transitions: spontaneous and cumulative syntheses of epithelial marker molecules and their assemblies to novel cell junctions connecting human hematopoietic tumor cells to carcinomatoid tissue structures. Int J Cancer. 2011;129:2588-99 pubmed publisher
    ..We discuss molecular mechanisms involved in the formation and function of these junctions, also with respect to tumor spread and metastasis, as well as diagnostic and therapeutic consequences...
  14. Schulte D, Küppers V, Dartsch N, Broermann A, Li H, Zarbock A, et al. Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 2011;30:4157-70 pubmed publisher
    ..Furthermore, in these tissues, plasticity of the VE-cadherin-catenin complex is central for the leukocyte diapedesis mechanism...
  15. Yonemura S. Cadherin-actin interactions at adherens junctions. Curr Opin Cell Biol. 2011;23:515-22 pubmed publisher
    ..Here, I provide an overview of cadherin-actin interaction from morphological aspects and of possible molecular mechanisms revealed by recent studies...
  16. Rauzi M, Lenne P, Lecuit T. Planar polarized actomyosin contractile flows control epithelial junction remodelling. Nature. 2010;468:1110-4 pubmed publisher
    ..Thus, epithelial morphogenesis is not properly reflected by Myosin II steady state distribution but by polarized contractile actomyosin flows that emerge from interactions between E-cadherin and actomyosin networks...
  17. Liu J, Stockton R, Gingras A, Ablooglu A, Han J, Bobkov A, et al. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell. 2011;22:2509-19 pubmed publisher
    ..These studies establish that the direct physical interaction of Rap1 with KRIT1 enables the translocation of microtubule-sequestered KRIT1 to junctions, thereby supporting junctional integrity and cardiovascular development...
  18. Ke X, Li W, Hovland R, Qu Y, Liu R, McCormack E, et al. Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. Exp Cell Res. 2011;317:234-47 pubmed publisher
    ..Reprogramming of cell junction modules is involved in both steps...
  19. Hussain F, Morton P, Snippe M, Sullivan J, Farmer C, Martin Fernandez M, et al. CAR modulates E-cadherin dynamics in the presence of adenovirus type 5. PLoS ONE. 2011;6:e23056 pubmed publisher
    ..As increased paracellular permeability was observed early after the addition of Ad5 to cells, we postulate that this may represent a mechanism by which Ad5 could disrupt cell junctions to facilitate further access to its cell receptors...
  20. Gomez G, McLachlan R, Yap A. Productive tension: force-sensing and homeostasis of cell-cell junctions. Trends Cell Biol. 2011;21:499-505 pubmed publisher
    ..In this review, we examine these advances and discuss their implications...
  21. Schumacher J, Bloomekatz J, Garavito Aguilar Z, Yelon D. tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Dev Biol. 2013;383:214-26 pubmed publisher
    ..We therefore propose a model in which Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions and maintaining endocardial identity.
  22. Guillot C, Lecuit T. Mechanics of epithelial tissue homeostasis and morphogenesis. Science. 2013;340:1185-9 pubmed publisher
    ..Tissue fluidity emerges from local active stresses acting at cell interfaces and allows the maintenance of epithelial organization during morphogenesis and tissue renewal...
  23. Verhoekx J, Verjee L, Izadi D, Chan J, Nicolaidou V, Davidson D, et al. Isometric contraction of Dupuytren's myofibroblasts is inhibited by blocking intercellular junctions. J Invest Dermatol. 2013;133:2664-2671 pubmed publisher
    ..Therefore, we studied intercellular junctions of primary human MFs derived from patients with Dupuytren's disease, a fibrotic disorder of the dermis ..
  24. Boggiano J, Fehon R. Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev Cell. 2012;22:695-702 pubmed publisher
    ..review, we discuss recent findings that emphasize the cell cortex-specifically the actin cytoskeleton, intercellular junctions, and protein complexes that determine cell polarity-as a key site for Hippo pathway regulation...
  25. Roh Johnson M, Shemer G, Higgins C, McClellan J, Werts A, Tulu U, et al. Triggering a cell shape change by exploiting preexisting actomyosin contractions. Science. 2012;335:1232-5 pubmed publisher
    ..Thus, apical constriction appears to be triggered not by a change in cortical tension, but by dynamic linking of apical cell-cell contact zones to an already contractile apical cortex...
  26. Nakajima H, Tanoue T. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. J Cell Biol. 2011;195:245-61 pubmed publisher
    ..These findings therefore reveal a novel molecular system regulating the circumferential actomyosin belt in epithelial cells...
  27. Blaskewicz C, Pudney J, Anderson D. Structure and function of intercellular junctions in human cervical and vaginal mucosal epithelia. Biol Reprod. 2011;85:97-104 pubmed publisher
    ..To further define the molecular structure of the intercellular junctions, select junctional molecules were localized in the endocervical, ectocervical, and vaginal epithelium by ..
  28. Morris L, DeGagne J, Kempton J, Hausman F, Trune D. Mouse middle ear ion homeostasis channels and intercellular junctions. PLoS ONE. 2012;7:e39004 pubmed publisher
    ..The middle ear contains homeostatic mechanisms that control the movement of ions and fluids similar to those present in the inner ear, and are altered during inflammation...
  29. Mruk D, Lau A. RAB13 participates in ectoplasmic specialization dynamics in the rat testis. Biol Reprod. 2009;80:590-601 pubmed publisher
    ..Taken collectively, these results suggest that RAB13 functions in ectoplasmic specialization dynamics in the testis. ..
  30. Tan S, Tompkins L, Amieva M. Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche. PLoS Pathog. 2009;5:e1000407 pubmed publisher
    ..on the cell surface and find that Hp is able to replicate and form microcolonies directly over the intercellular junctions. On polarized epithelia, Hp is able to grow directly on the apical cell surface in conditions that do not ..
  31. Asimaki A, Tandri H, Huang H, Halushka M, Gautam S, Basso C, et al. A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med. 2009;360:1075-84 pubmed publisher
    ..Routine immunohistochemical analysis of a conventional endomyocardial-biopsy sample appears to be a highly sensitive and specific diagnostic test for ARVC. ..
  32. den Elzen N, Buttery C, Maddugoda M, Ren G, Yap A. Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell. 2009;20:3740-50 pubmed publisher
    ..Together, these findings establish a novel morphogenetic function for cadherin adhesion receptors to guide spindle orientation during symmetric cell division. ..
  33. Coureuil M, Mikaty G, Miller F, Lecuyer H, Bernard C, Bourdoulous S, et al. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science. 2009;325:83-7 pubmed publisher
    ..complex that plays a pivotal role in the establishment of eukaryotic cell polarity and the formation of intercellular junctions. This recruitment leads to the formation of ectopic intercellular junctional domains at the site of ..
  34. Montero Balaguer M, Swirsding K, Orsenigo F, Cotelli F, Mione M, Dejana E. Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos. PLoS ONE. 2009;4:e5772 pubmed publisher
    ..This suggests that partial internalization or change of function of this protein may strongly affect vascular stability and organization. ..
  35. Fan T, Wang D, Zhao J, Wang J, Fu Y, Guo R. Establishment and characterization of a novel untransfected corneal endothelial cell line from New Zealand white rabbits. Mol Vis. 2009;15:1070-8 pubmed
    ..To establish and characterize a novel untransfected corneal endothelial cell line from New Zealand white rabbits (NRCE cell line) for studies on corneal endothelial cells...
  36. Simone R, Dinardo S. Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. Development. 2010;137:1385-94 pubmed publisher
    ..Indeed, depletion of Myosin II or dlg disrupts these processes. These results show that tight spatial regulation of actomyosin contractility is required to produce this high-energy arrangement of cells...
  37. Koch S, Nusrat A. Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions. Ann N Y Acad Sci. 2009;1165:220-7 pubmed publisher
    ..Epithelial barrier function is provided by tightly regulated intercellular junctions, which consist of a plethora of membrane-associated and transmembrane proteins organized in discreet, ..
  38. Sevilla L, Nachat R, Groot K, Watt F. Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. J Cell Sci. 2008;121:3561-9 pubmed publisher
    ..changes in cell shape, reduced filamentous actin, reorganized keratin filaments, and impaired assembly of intercellular junctions. These effects were attributable to decreased Rho activity in kazrin-overexpressing cells...
  39. Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, et al. Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res. 2008;103:1164-72 pubmed publisher
    ..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
  40. Klessner J, Desai B, Amargo E, Getsios S, Green K. EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2. Mol Biol Cell. 2009;20:328-37 pubmed publisher
    ..Here, we show that EGFR inhibition stabilizes Dsg2 at intercellular junctions by interfering with its accumulation in an internalized cytoplasmic pool...
  41. Li Q, Mattingly R. Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells. Neoplasia. 2008;10:1444-58 pubmed
  42. Lee T, Lee D, Kim H, Ko J, Gronostajski R, Cho M, et al. Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation. J Histochem Cytochem. 2009;57:469-76 pubmed publisher
    ..The most striking changes observed in these aberrant odontoblasts were the loss of intercellular junctions and the decreased expression of ZO-1 and occludin...
  43. Dejana E, Tournier Lasserve E, Weinstein B. The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell. 2009;16:209-21 pubmed publisher
    ..In this review we discuss recent findings derived from these approaches and their possible integration in a common picture...
  44. Taulet N, Comunale F, Favard C, Charrasse S, Bodin S, Gauthier Rouvière C. N-cadherin/p120 catenin association at cell-cell contacts occurs in cholesterol-rich membrane domains and is required for RhoA activation and myogenesis. J Biol Chem. 2009;284:23137-45 pubmed publisher
    ..Thus, a functional N-cadherin-catenin complex occurs in cholesterol-rich membrane microdomains which allows the recruitment of RhoA and the regulation of its activity during myogenesis induction...
  45. Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, et al. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008;183:19-28 pubmed publisher
    ..We propose that keratins and the keratin-binding protein Albatross are important for epithelial cell polarization...
  46. Ivanov A, Parkos C, Nusrat A. Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol. 2010;177:512-24 pubmed publisher
    ..properties of epithelial layers are regulated by specialized adhesive plasma membrane structures known as intercellular junctions. It is generally believed that inflammatory stimuli increase transepithelial permeability by inducing ..
  47. Fujita S, Terasaki F, Otsuka K, Katashima T, Kanzaki Y, Kawamura K, et al. Markedly increased intracellular lipid droplets and disruption of intercellular junctions in biopsied myocardium from a patient with arrhythmogenic right ventricular cardiomyopathy. Heart Vessels. 2008;23:440-4 pubmed publisher
    ..Disruptions of the plasma membrane and dissociation of intercellular junctions were associated with discharge of intracellular lipid droplets into the interstitial space...
  48. Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, et al. Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1. Exp Cell Res. 2009;315:1480-9 pubmed publisher
    ..These data reveal that Cdc42 is crucial for the formation of mature epithelial cell junctions between keratinocytes by regulating activation of aPKCzeta...
  49. Manz B, Groves J. Spatial organization and signal transduction at intercellular junctions. Nat Rev Mol Cell Biol. 2010;11:342-52 pubmed publisher
    ..The resulting spatial mutations yield insights into the interweaving of the spatial, mechanical and chemical aspects of intercellular signalling...
  50. Jambou R, Combes V, Jambou M, Weksler B, Couraud P, Grau G. Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions. PLoS Pathog. 2010;6:e1001021 pubmed publisher
    ..This is associated with the opening of the intercellular junctions. The transfer of IRBC antigens can thus transform EC into a target for the immune response and contribute ..
  51. Zeeb M, Strilic B, Lammert E. Resolving cell-cell junctions: lumen formation in blood vessels. Curr Opin Cell Biol. 2010;22:626-32 pubmed publisher
    ..Here we review the role of EC junctions in vascular lumen formation within different vascular beds...
  52. Godsel L, Dubash A, Bass Zubek A, Amargo E, Klessner J, Hobbs R, et al. Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell. 2010;21:2844-59 pubmed publisher
    ..Together with our previous findings, these data suggest that PKP2 may functionally link RhoA- and PKC-dependent pathways to drive actin reorganization and regulate DP-IF interactions required for normal desmosome assembly...
  53. Navarro Moreno L, Quintanar Escorza M, Gonzalez S, Mondragon R, Cerbón Solorzáno J, Valdes J, et al. Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells. Toxicol In Vitro. 2009;23:1298-304 pubmed publisher
    ..Our work contributes in the understanding of the physiopathology of lead intoxication on the structure of renal tubular epithelial cell-cell contacts in vivo...
  54. Noda K, Zhang J, Fukuhara S, Kunimoto S, Yoshimura M, Mochizuki N. Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells. Mol Biol Cell. 2010;21:584-96 pubmed publisher
  55. Green K, Getsios S, Troyanovsky S, Godsel L. Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol. 2010;2:a000125 pubmed publisher
    ..We will explore signaling and trafficking machineries that drive assembly and remodeling and how these mechanisms are co-opted in human disease...
  56. Fanning A, Anderson J. Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci. 2009;1165:113-20 pubmed publisher
    ..Finally, we propose a model by which the functional activities of ZO proteins in the adherens junction and tight junction are differentiated by a novel regulatory motif known as the U6 or acidic motif...
  57. Dupin I, Camand E, Etienne Manneville S. Classical cadherins control nucleus and centrosome position and cell polarity. J Cell Biol. 2009;185:779-86 pubmed publisher
    ..Our results demonstrate that in addition to the specific function of E-cadherin in regulating baso-apical epithelial polarity, classical cadherins control cell polarization in otherwise nonpolarized cells...
  58. Vincent T, Neve E, Johnson J, Kukalev A, Rojo F, Albanell J, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol. 2009;11:943-50 pubmed publisher
    ..We propose that activation of a SNAIL1-SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT...
  59. Maher M, Flozak A, Stocker A, Chenn A, Gottardi C. Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol. 2009;186:219-28 pubmed publisher
  60. Abouhamed M, Grobe K, San I, Thelen S, Honnert U, Balda M, et al. Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus. Mol Biol Cell. 2009;20:5074-85 pubmed publisher
    ..resulted in a distorted ependyma due to irregular epithelial cell morphology and altered organization of intercellular junctions. Ependymal cells occasionally delaminated, forming multilayered structures that bridged the CSF-filled ..
  61. Gore A, Lampugnani M, Dye L, Dejana E, Weinstein B. Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Dis Model Mech. 2008;1:275-81 pubmed publisher
    ..These findings support the idea that minor polygenic deficits in the CCM pathway can strongly synergize to initiate ICH. ..
  62. Nottebaum A, Cagna G, Winderlich M, Gamp A, Linnepe R, Polaschegg C, et al. VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med. 2008;205:2929-45 pubmed publisher
    ..In conclusion, leukocytes interacting with endothelial cells rapidly dissociate VE-PTP from VE-cadherin, weakening endothelial cell contacts via a mechanism that requires plakoglobin but not beta-catenin...
  63. Abraham S, Yeo M, Montero Balaguer M, Paterson H, Dejana E, Marshall C, et al. VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation. Curr Biol. 2009;19:668-74 pubmed publisher
    ..How sprouting is halted is not known, but it is contemporaneous with the development of stable intercellular junctions [1]...
  64. Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi Kobayashi S, et al. Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. Circ Res. 2010;106:1731-42 pubmed publisher
    ..It is not known whether afadin, an adherens junction protein that connects immunoglobulin-like adhesion molecule nectins to the actin cytoskeleton and binds activated Rap1, plays a role in angiogenesis...
  65. Gavard J. Breaking the VE-cadherin bonds. FEBS Lett. 2009;583:1-6 pubmed publisher
    ..These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis...
  66. Almagro S, Durmort C, Chervin Pétinot A, Heyraud S, Dubois M, Lambert O, et al. The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts. Mol Cell Biol. 2010;30:1703-17 pubmed publisher
    ..This mechanism may have functional consequences for endothelium repair in pathological settings...
  67. Gonzalez Andrades M, Garzon I, Gascón M, Muñoz Avila J, Sanchez Quevedo M, Campos A, et al. Sequential development of intercellular junctions in bioengineered human corneas. J Tissue Eng Regen Med. 2009;3:442-9 pubmed publisher
    ..revealed that artificial corneas with one or two epithelial cell layers did not show any formation of intercellular junctions. In contrast, several types of cell-cell junction, especially desmosomes, were found in multilayered ..
  68. Beckers C, van Hinsbergh V, van Nieuw Amerongen G. Driving Rho GTPase activity in endothelial cells regulates barrier integrity. Thromb Haemost. 2010;103:40-55 pubmed publisher
    ..The challenge and promise lies in unfolding this complex regulation, as this will provide leads for new therapeutic opportunities...