hemidesmosomes

Summary

Summary: An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.

Top Publications

  1. Hormia M, Owaribe K, Virtanen I. The dento-epithelial junction: cell adhesion by type I hemidesmosomes in the absence of a true basal lamina. J Periodontol. 2001;72:788-97 pubmed
    ..Ultrastructurally, this attachment occurs through hemidesmosomes (HD) and a basal lamina-like extracellular matrix which, on the tooth side, is termed the internal basal ..
  2. French K, Pollitt C. Equine laminitis: loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: an ultrastructural study. Equine Vet J. 2004;36:230-5 pubmed
    ..This could lead to better understanding of the pathogenesis of lesions and the means of treatment or prevention...
  3. Tsuruta D, Hopkinson S, Jones J. Hemidesmosome protein dynamics in live epithelial cells. Cell Motil Cytoskeleton. 2003;54:122-34 pubmed
    b>Hemidesmosomes mediate stable anchorage of epithelial cells to laminin-5 in the basement membrane zone and have been likened to spot-welds...
  4. Hirako Y, Yoshino K, Zillikens D, Owaribe K. Extracellular cleavage of bullous pemphigoid antigen 180/type XVII collagen and its involvement in hemidesmosomal disassembly. J Biochem. 2003;133:197-206 pubmed
    ..Our observations demonstrate that the cleavage of BP180 occurring within the NC16A domain is mediated by a membrane-associated metalloprotease and suggest a possible involvement of the cleavage in hemidesmosomal disassembly...
  5. Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, et al. Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet. 2011;7:e1002396 pubmed publisher
    ..We propose focal self-association of plectin molecules as a novel mechanism contributing to hemidesmosome homeostasis and stabilization...
  6. Wilhelmsen K, Litjens S, Kuikman I, Margadant C, van Rheenen J, Sonnenberg A. Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell. 2007;18:3512-22 pubmed
    b>Hemidesmosomes (HDs) are multiprotein adhesion complexes that promote attachment of epithelial cells to the basement membrane. The binding of alpha6beta4 to plectin plays a central role in their assembly...
  7. Bercher M, Wahl J, Vogel B, Lu C, Hedgecock E, Hall D, et al. mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes. J Cell Biol. 2001;154:415-26 pubmed
    ..MUA-3 localizes to the hypodermal hemidesmosomes and to other sites of mechanically robust transepithelial attachments, including the rectum, vulva, ..
  8. Germain E, Santos T, Rabinovitz I. Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell. 2009;20:56-67 pubmed publisher
    b>Hemidesmosomes (HDs) are multiprotein structures that anchor epithelial cells to the basement membrane. HD components include the alpha6beta4 integrin, plectin, and BPAGs (bullous pemphigoid antigens)...
  9. Hong L, Elbl T, Ward J, Franzini Armstrong C, Rybicka K, Gatewood B, et al. MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans. J Cell Biol. 2001;154:403-14 pubmed
    ..MUP-4 colocalizes with epithelial hemidesmosomes overlying body wall muscles, beginning at the time of embryonic cuticle maturation, as well as with other ..

More Information

Publications81

  1. French K, Pollitt C. Equine laminitis: cleavage of laminin 5 associated with basement membrane dysadhesion. Equine Vet J. 2004;36:242-7 pubmed
    ..For this to happen the structural and adhesion proteins of the basement membrane zone must be altered. Which proteins and how damage to them leads to the lamellar separation of laminitis is unknown...
  2. Ozawa T, Tsuruta D, Jones J, Ishii M, Ikeda K, Harada T, et al. Dynamic relationship of focal contacts and hemidesmosome protein complexes in live cells. J Invest Dermatol. 2010;130:1624-35 pubmed publisher
    Epidermal cells adhere to the basement membrane zone through cell-matrix junctions termed hemidesmosomes. During wound healing, hemidesmosomes are disassembled to allow keratinocytes to move over wound sites...
  3. Werner M, Chen F, Moyano J, Yehiely F, Jones J, Cryns V. Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration. J Biol Chem. 2007;282:5560-9 pubmed
    ..integrin anchors epithelial cells to the basement membrane at specialized adhesive structures known as hemidesmosomes and plays a critical role in diverse epithelial cell functions including cell survival and migration...
  4. Litjens S, de Pereda J, Sonnenberg A. Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol. 2006;16:376-83 pubmed
    b>Hemidesmosomes are multiprotein adhesion complexes that promote epithelial stromal attachment in stratified and complex epithelia...
  5. Tsuruta D, Hashimoto T, Hamill K, Jones J. Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing. J Dermatol Sci. 2011;62:1-7 pubmed publisher
    ..skin, adhesion of the keratinocytes in the basal layer of the epidermis to the BMZ is facilitated primarily by hemidesmosomes which associate with the keratin cytoskeleton...
  6. Geuijen C, Sonnenberg A. Dynamics of the alpha6beta4 integrin in keratinocytes. Mol Biol Cell. 2002;13:3845-58 pubmed
    ..During cell migration and division, the beta4-EGFP and EGFP-beta4 hemidesmosomes disappear, and a proportion of the beta4-EGFP, but not of the EGFP-beta4 molecules, become part of retraction ..
  7. Mizutani K, Kawano S, Minami A, Waseda M, Ikeda W, Takai Y. Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes. J Biol Chem. 2011;286:36667-76 pubmed publisher
    In normal epithelial cells, integrin ?(6)?(4) is abundantly expressed and forms hemidesmosomes, which is a cellular structure that mediates cell-extracellular matrix binding...
  8. Hatakeyama S, Hayashi S, Yoshida Y, Otsubo A, Yoshimoto K, Oikawa Y, et al. Retinoic acid disintegrated desmosomes and hemidesmosomes in stratified oral keratinocytes. J Oral Pathol Med. 2004;33:622-8 pubmed
    ..The effects of all-trans RA on cell-cell and cell-matrix connections of gingival epithelial (GE)1 cells in a multilayered culture were investigated...
  9. de Pereda J, Lillo M, Sonnenberg A. Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes. EMBO J. 2009;28:1180-90 pubmed publisher
    The interaction between the integrin alpha6beta4 and plectin is essential for the assembly and stability of hemidesmosomes, which are junctional adhesion complexes that anchor epithelial cells to the basement membrane...
  10. Herold Mende C, Kartenbeck J, Tomakidi P, Bosch F. Metastatic growth of squamous cell carcinomas is correlated with upregulation and redistribution of hemidesmosomal components. Cell Tissue Res. 2001;306:399-408 pubmed
    Bullous pemphigoid antigen-1 (BPA1) and alpha(6)beta(4)-integrin colocalize at the hemidesmosomes in basal-layer keratinocytes of normal squamous epithelia...
  11. Kostan J, Gregor M, Walko G, Wiche G. Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin. J Biol Chem. 2009;284:18525-36 pubmed publisher
    ..Integrin alpha6beta4-plectin interaction plays a major role in the formation of hemidesmosomes, and thus the mechanisms regulating this interaction should be critical also for the disassembly process...
  12. Jonkman M, Pas H, Nijenhuis M, Kloosterhuis G, Steege G. Deletion of a cytoplasmic domain of integrin beta4 causes epidermolysis bullosa simplex. J Invest Dermatol. 2002;119:1275-81 pubmed
  13. Margadant C, Frijns E, Wilhelmsen K, Sonnenberg A. Regulation of hemidesmosome disassembly by growth factor receptors. Curr Opin Cell Biol. 2008;20:589-96 pubmed publisher
    b>Hemidesmosomes (HDs) promote the stable adhesion of basal epithelial cells to the underlying basement membrane (BM)...
  14. Koster J, Kuikman I, Kreft M, Sonnenberg A. Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin. J Invest Dermatol. 2001;117:1405-11 pubmed
    The integrin alpha 6 beta 4 plays a crucial role in the assembly and maintenance of hemidesmosomes. Previous work has shown that the recruitment of plectin into hemidesmosomes is dependent on beta 4 and involves a region of the beta 4 ..
  15. Faure E, Garrouste F, Parat F, Monferran S, Leloup L, Pommier G, et al. P2Y2 receptor inhibits EGF-induced MAPK pathway to stabilise keratinocyte hemidesmosomes. J Cell Sci. 2012;125:4264-77 pubmed publisher
    6?4 integrin is the main component of hemidesmosomes (HD) that stably anchor the epithelium to the underlying basement membrane. Epithelial cell migration requires HD remodelling, which can be promoted by epidermal growth factor (EGF)...
  16. Frijns E, Sachs N, Kreft M, Wilhelmsen K, Sonnenberg A. EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem. 2010;285:37650-62 pubmed publisher
    Migration of keratinocytes requires a regulated and dynamic turnover of hemidesmosomes (HDs)...
  17. Groves R, Liu L, Dopping Hepenstal P, Markus H, Lovell P, Ozoemena L, et al. A homozygous nonsense mutation within the dystonin gene coding for the coiled-coil domain of the epithelial isoform of BPAG1 underlies a new subtype of autosomal recessive epidermolysis bullosa simplex. J Invest Dermatol. 2010;130:1551-7 pubmed publisher
    ..With regard to skin blistering, the clinicopathological findings expand the molecular basis of EB by identifying BPAG1-e pathology in a new form of autosomal recessive EB simplex...
  18. de Pereda J, Ortega E, Alonso García N, Gómez Hernández M, Sonnenberg A. Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology. Cell Adh Migr. 2009;3:361-4 pubmed
    b>Hemidesmosomes (HD) are adhesive protein complexes that mediate stable attachment of basal epithelial cells to the underlying basement membrane...
  19. Nguyen N, Pulkkinen L, Schlueter J, Meneguzzi G, Uitto J, Senior R. Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation. Respir Res. 2006;7:28 pubmed
    ..Targeted deletion of the laminin gamma2 gene in mice results in skin blistering and neonatal death at 3-5 days after birth due to failure to thrive...
  20. Rabinovitz I, Tsomo L, Mercurio A. Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol. 2004;24:4351-60 pubmed
    ..Importantly, phosphorylation of these serines is critical for the ability of EGF to disrupt hemidesmosomes. Using COS-7 cells, which assemble hemidesmosomes type II upon exogenous expression of the alpha 6 beta 4 ..
  21. Koster J, van Wilpe S, Kuikman I, Litjens S, Sonnenberg A. Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes. Mol Biol Cell. 2004;15:1211-23 pubmed
    We have previously shown that plectin is recruited into hemidesmosomes through association of its actin-binding domain (ABD) with the first pair of fibronectin type III (FNIII) repeats and a small part of the connecting segment (residues ..
  22. McMillan J, Akiyama M, Nakamura H, Shimizu H. Colocalization of multiple laminin isoforms predominantly beneath hemidesmosomes in the upper lamina densa of the epidermal basement membrane. J Histochem Cytochem. 2006;54:109-18 pubmed
    ..This suggests that laminin-10-associated chains have specific functions or molecular interactions beneath HDs in the epidermal basement membrane...
  23. Baudoin C, Fantin L, Meneguzzi G. Proteolytic processing of the laminin alpha3 G domain mediates assembly of hemidesmosomes but has no role on keratinocyte migration. J Invest Dermatol. 2005;125:883-8 pubmed
    ..cell lines, the proteolytic truncation of the C-terminal G domain of the Lm alpha3 chain induces assembly of hemidesmosomes and downregulates cell migration...
  24. Fassihi H, Wong T, Wessagowit V, McGrath J, Mellerio J. Target proteins in inherited and acquired blistering skin disorders. Clin Exp Dermatol. 2006;31:252-9 pubmed
    ..The major adhesion units that achieve this are the hemidesmosomes and desmosomes, but when these structures are disrupted, e.g...
  25. Mariotti A, Kedeshian P, Dans M, Curatola A, Gagnoux Palacios L, Giancotti F. EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol. 2001;155:447-58 pubmed
    ..Activation of the EGF-R causes tyrosine phosphorylation of the beta4 cytoplasmic domain and disruption of hemidesmosomes. The Src family kinase inhibitors PP1 and PP2 prevent tyrosine phosphorylation of beta4 and disassembly of ..
  26. Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Huttelmaier S, et al. Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol. 2013;133:181-90 pubmed publisher
    ..They support the view that the downregulation of keratins observed during epithelial-mesenchymal transition supports the migratory and invasive behavior of tumor cells...
  27. Koster J, Geerts D, Favre B, Borradori L, Sonnenberg A. Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. J Cell Sci. 2003;116:387-99 pubmed
    b>Hemidesmosomes (HDs) are multi-protein complexes that promote stable adhesion of epithelial cells to the underlying extracellular matrix...
  28. Sawant S, Kandarkar S. Role of vitamins C and E as chemopreventive agents in the hamster cheek pouch treated with the oral carcinogen-DMBA. Oral Dis. 2000;6:241-7 pubmed
    ..in a discontinuous, fragmented, broken and diffused basement membrane, with diminished lamina densa, fewer hemidesmosomes and invagination of the basal cell cytoplasmic processes in the subepithelium...
  29. Katbab A, Owji S, Eghtedari M. Morphologic changes of corneal epithelial flap: ethanol-mediated versus mechanical removal. Ultrastruct Pathol. 2012;36:400-3 pubmed publisher
    ..In mechanical debridement, cleavages extended more than half of the cell length by tearing hemidesmosomes. Alcohol application leads to cell damage in basal epithelial cells but cleavage plane remains smooth...
  30. Fujiseki M, Matsuzaka K, Yoshinari M, Shimono M, Inoue T. An experimental study on the features of peri-implant epithelium: immunohistochemical and electron-microscopic observations. Bull Tokyo Dent Coll. 2003;44:185-99 pubmed
    ..Taken together, the peri-implant epithelium is similar to that seen in the oral mucosa, and it is structurally different from the junctional epithelium. ..
  31. Builles N, Bechetoille N, Justin V, Andre V, Barbaro V, Di Iorio E, et al. Development of a hemicornea from human primary cell cultures for pharmacotoxicology testing. Cell Biol Toxicol. 2007;23:279-92 pubmed
    ..cuboidal basal epithelial cells were anchored to a basement membrane containing collagen IV, laminin 5, and hemidesmosomes. In the stromal part, the keratocytes colonized the porous scaffold, formed a network of interconnecting cells,..
  32. Ogawa T, Tsubota Y, Hashimoto J, Kariya Y, Miyazaki K. The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain. Mol Biol Cell. 2007;18:1621-33 pubmed
    ..These results demonstrate that domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility. ..
  33. Pirilä E, Parikka M, Ramamurthy N, Maisi P, McClain S, Kucine A, et al. Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain. Wound Repair Regen. 2002;10:38-51 pubmed
    ..e., laminin-5 gamma2-chain. This study shows, for the first time, the role of estrogen and CMT-8 in laminin-5 gamma2-chain modulation in vivo. ..
  34. Iriyama S, Tsunenaga M, Amano S, Adachi E. Key role of heparan sulfate chains in assembly of anchoring complex at the dermal-epidermal junction. Exp Dermatol. 2011;20:953-5 pubmed publisher
    Epidermal basement membrane forms anchoring complex composed of hemidesmosomes, anchoring filaments, lamina densa and anchoring fibrils to link epidermis to dermis...
  35. Li Q, Frank M, Akiyama M, Shimizu H, Ho S, Thisse C, et al. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Dis Model Mech. 2011;4:777-85 pubmed publisher
    ..epidermis separated from the underlying collagenous stroma by a basement membrane with fully developed hemidesmosomes. Scanning electron microscopy (SEM) reveals an ordered surface contour of keratinocytes with discrete ..
  36. Pakkala T, Virtanen I, Oksanen J, Jones J, Hormia M. Function of laminins and laminin-binding integrins in gingival epithelial cell adhesion. J Periodontol. 2002;73:709-19 pubmed
    ..Our results provide new information on gingival epithelial cell adhesion and extracellular matrix production and may thus aid in the understanding of periodontal physiology. ..
  37. Uematsu J, Nishizawa Y, Hirako Y, Kitamura K, Usukura J, Miyata T, et al. Both type-I hemidesmosomes and adherens-type junctions contribute to the cell-substratum adhesion system in myoepithelial cells. Eur J Cell Biol. 2005;84:407-15 pubmed
    ..Type-I hemidesmosomes (HDs) consisting of plectin, BP230, integrin alpha6beta4, and BP180 were thus observed as punctate arrays ..
  38. Patsatsi A, Vyzantiadis T, Devliotou Panagiotidou D, Chrysomallis F, Sotiriadis D. Detection of anti-BP180NC16a and anti-BP230 autoantibodies in blister fluid of patients with bullous pemphigoid: the first survey in Greece. Clin Exp Dermatol. 2008;33:183-5 pubmed
    ..Our results indicate that blister-fluid examination by ELISA can be a useful tool to diagnose bullous pemphigoid, especially in elderly patients who refuse biopsy or have poor venous access. ..
  39. Kligys K, Jones J. Flii control: balancing migration and adhesion. J Invest Dermatol. 2009;129:1856-8 pubmed publisher
    ..We discuss potential mechanisms that could explain how this unique gelsolin family member might regulate both stable keratinocyte adhesion and motility. ..
  40. Hapiak V, Hresko M, Schriefer L, Saiyasisongkhram K, Bercher M, Plenefisch J. mua-6, a gene required for tissue integrity in Caenorhabditis elegans, encodes a cytoplasmic intermediate filament. Dev Biol. 2003;263:330-42 pubmed
    ..that a MUA-6/IFA-2::GFP fusion protein that rescues the presumptive mua-6 null allele localizes to hypodermal hemidesmosomes. This result is consistent with what is known about the function of cIFs in vertebrates...
  41. Alvarez Lorenzo M, Blanco Carrion A, Antúnez López J, Gandara Vila P, Garcia Garcia A, Gandara Rey J. [Ultrastructural differences between leukoplakia with and without dysplasia]. Bull Group Int Rech Sci Stomatol Odontol. 2001;43:37-45 pubmed
    ..In this study we investigate in depth the cellular ultrastructure of the tissues which determines the clinical behaviour of these lesions. ..
  42. Lipovsek S, Janžekovič F, Novak T. Ultrastructure of fat body cells and Malpighian tubule cells in overwintering Scoliopteryx libatrix (Noctuoidea). Protoplasma. 2017;254:2189-2199 pubmed publisher
    ..The epithelial cells were attached to the basal lamina by numerous hemidesmosomes. The apical plasma membrane was differentiated into numerous microvilli, many of them containing mitochondria...
  43. Schultes G, Gaggl A. Histologic evaluation of immediate versus delayed placement of implants after tooth extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:17-22 pubmed
    ..of the implant was more dense; the delayed implants also had a greater number of adhesive epithelial elements (hemidesmosomes). Use of dynamic and static histomorphometry revealed no significant differences between the 2 groups...
  44. Alt A, Ohba M, Li L, Gartsbein M, Belanger A, Denning M, et al. Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment. Cancer Res. 2001;61:4591-8 pubmed
    ..suprabasally, and retain the expression of the alpha6beta4 integrin in suprabasal cells disassociated from the hemidesmosomes. We now show that the alpha6beta4 integrin is a substrate for serine phosphorylation by protein kinase C in ..
  45. Dellambra E, Prislei S, Salvati A, Madeddu M, Golisano O, Siviero E, et al. Gene correction of integrin beta4-dependent pyloric atresia-junctional epidermolysis bullosa keratinocytes establishes a role for beta4 tyrosines 1422 and 1440 in hemidesmosome assembly. J Biol Chem. 2001;276:41336-42 pubmed
    ..Furthermore, the number of hemidesmosomes was strikingly reduced as compared with beta4-corrected keratinocytes...
  46. De Pascalis C, Etienne Manneville S. Single and collective cell migration: the mechanics of adhesions. Mol Biol Cell. 2017;28:1833-1846 pubmed publisher
    ..Interactions with the extracellular matrix (ECM) occur through focal adhesions or hemidesmosomes via the engagement of integrins with fibrillar ECM proteins...
  47. Pöllänen M, Salonen J. Effect of short chain fatty acids on human gingival epithelial cell keratins in vitro. Eur J Oral Sci. 2000;108:523-9 pubmed
  48. Cheng E, Maruyama I, Sundarraj N, Sugar J, Feder R, Yue B. Expression of type XII collagen and hemidesmosome-associated proteins in keratoconus corneas. Curr Eye Res. 2001;22:333-40 pubmed
    ..This study was performed to examine the expression of type XII collagen, proteins associated with hemidesmosomes, and beta1 integrin in keratoconus corneas.
  49. Hahn B, Labouesse M. Tissue integrity: hemidesmosomes and resistance to stress. Curr Biol. 2001;11:R858-61 pubmed
  50. Liu Z. Immunopathology of bullous pemphigoid, an autoimmune and inflammatory skin blistering disease. Keio J Med. 2003;52:128-33 pubmed
    ..The IgG passive transfer and active models of BP provide us with invaluable in vivo systems not only for dissecting cellular and humoral responses in BP but also for developing effective therapies for this disease...
  51. Adair Kirk T, Griffin G, Meyer M, Kelley D, Miner J, Keene D, et al. Keratinocyte-targeted expression of human laminin ?2 rescues skin blistering and early lethality of laminin ?2 deficient mice. PLoS ONE. 2012;7:e45546 pubmed publisher
    ..In skin, laminin-332 is secreted by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the underlying dermis...
  52. Herlevsen M, Schmidt D, Miyazaki K, Zoller M. The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation. J Cell Sci. 2003;116:4373-90 pubmed
    ..The findings provide a convincing experimental explanation for the repeatedly described involvement of alpha6beta4 in tumor progression...
  53. Sawada T, Inoue S. Mineralization of basement membrane mediates dentogingival adhesion in mammalian and nonmammalian vertebrates. Calcif Tissue Int. 2003;73:186-95 pubmed
    ..At the border, the internal basement membrane, which is firmly bound to the junctional epithelium through hemidesmosomes, was specialized differently in these species...
  54. Fontao L, Tasanen K, Huber M, Hohl D, Koster J, Bruckner Tuderman L, et al. Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bullosa simplex. J Invest Dermatol. 2004;122:65-72 pubmed
    ..The results demonstrate that: (1) in cultured keratinocytes of the patient, the assembly of hemidesmosomes, and their linkage with intermediate filaments are impaired; (2) BP180 Delta 18-407 is not capable of binding ..
  55. Spinardi L, Rietdorf J, Nitsch L, Bono M, Tacchetti C, Way M, et al. A dynamic podosome-like structure of epithelial cells. Exp Cell Res. 2004;295:360-74 pubmed
    Focal contacts and hemidesmosomes are cell-matrix adhesion structures of cultured epithelial cells. While focal contacts link the extracellular matrix to microfilaments, hemidesmosomes make connections with intermediate filaments...
  56. Shinkuma S, McMillan J, Shimizu H. Ultrastructure and molecular pathogenesis of epidermolysis bullosa. Clin Dermatol. 2011;29:412-9 pubmed publisher
    ..This contribution reviews TEM findings in the EB subtypes and discusses the importance of observations in the molecular morphology of HD and basement membrane associated structures...
  57. Hetherington S, Gally C, Fritz J, Polanowska J, Reboul J, Schwab Y, et al. PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis. Dev Biol. 2011;350:267-78 pubmed publisher
    ..To further define how hemidesmosomes might control elongation, we searched for factors interacting with the core hemidesmosome component, the ..
  58. Spinardi L, Marchisio P. Podosomes as smart regulators of cellular adhesion. Eur J Cell Biol. 2006;85:191-4 pubmed
    ..in cultured epithelial cells where cell-matrix adhesion structures were represented only by focal contacts and hemidesmosomes interacting with microfilaments and intermediate filaments, respectively...
  59. Underwood J, Imbalzano K, Weaver V, Fischer A, Imbalzano A, Nickerson J. The ultrastructure of MCF-10A acini. J Cell Physiol. 2006;208:141-8 pubmed
    ..The tissue architecture of MCF-10A acini was formed by hemidesmosomes connected to a basement membrane and by abundant desmosomes between acinar cells...
  60. Zagon I, Sassani J, Ruth T, McLaughlin P. Epithelial adhesion complexes and organ culture of the human cornea. Brain Res. 2001;900:205-13 pubmed
    ..The basement membrane was disorganized, and anchoring complexes composed of hemidesmosomes were often absent...
  61. Rossi S, Tirri T, Paldan H, Kuntsi Vaattovaara H, Tulamo R, Narhi T. Peri-implant tissue response to TiO2 surface modified implants. Clin Oral Implants Res. 2008;19:348-55 pubmed publisher
    ..The objective of this study was to evaluate peri-implant soft tissue attachment and alveolar bone height on nanoporous TiO(2) thin film on commercial titanium dental implants compared with unmodified standard implants...
  62. Su L, Lv X, Miao J. Integrin beta 4 in neural cells. Neuromolecular Med. 2008;10:316-21 pubmed publisher
    ..It is concentrated at the basement membrane zone, where it localizes to specialized adhesion structures called hemidesmosomes. In addition to its adhesive functions, novel insights have emerged regarding the specific roles of integrin ..
  63. Chaudhari P, Charles S, D Souza Z, Vaidya M. Hemidesmosomal linker proteins regulate cell motility, invasion and tumorigenicity in oral squamous cell carcinoma derived cells. Exp Cell Res. 2017;360:125-137 pubmed publisher
    ..These data together indicate that hemidesmosomal linker proteins regulate cell motility, invasion and tumorigenicity possibly through NDRG1 in OSCC derived cells. ..
  64. Iwata H, Kitajima Y. Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida. Exp Dermatol. 2013;22:381-5 pubmed publisher
  65. Cheng L, Hudson J. Ultrastructural changes in malignant transformation of oral mucosa. Br J Oral Maxillofac Surg. 2002;40:207-12 pubmed
    ..Together with other laboratory investigative techniques, transmission EM may be helpful in detecting malignant changes in oral mucosa...
  66. Frijns E, Kuikman I, Litjens S, Raspe M, Jalink K, Ports M, et al. Phosphorylation of threonine 1736 in the C-terminal tail of integrin ?4 contributes to hemidesmosome disassembly. Mol Biol Cell. 2012;23:1475-85 pubmed publisher
    ..In conclusion, we identify T1736 as a novel phosphorylation site that contributes to the regulation of hemidesmome disassembly, a dynamically regulated process involving the concerted phosphorylation of multiple ?4 residues...
  67. Yu P, Babicky M, Jaquish D, French R, Marayuma K, Mose E, et al. The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome. Int J Cancer. 2012;131:1744-54 pubmed publisher
    ..Plectin is a multifunctional protein that complexes with integrin-?4 (ITGB4) to form hemidesmosomes, serves as a scaffolding platform crucial to the function of numerous protein signaling pathways and was ..
  68. Kim M, Heo J, Lee J, Wee W, Lee J. Adhesion complex in cultivated limbal epithelium on amniotic membrane after in vivo transplantation. Curr Eye Res. 2005;30:639-46 pubmed
    ..To investigate adhesion complex formation in cultivated human limbal epithelium after transplantation into the limbal deficient model...
  69. Kim E, Kim D, Lee S, Kim M. Ultrastructural changes of cornea after ethanol ingestion in Otsuka Long-Evans Tokushima fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats. Graefes Arch Clin Exp Ophthalmol. 2010;248:1457-66 pubmed publisher
    ..To compare ethanol-induced ultrastructural changes in corneas of Otsuka Long-Evans Tokushima fatty (OLETF) rats and Long-Evans Tokushima Otsuka (LETO) rats...
  70. Kitajima Y. Cross-talk between hemidesmosomes and focal contacts: understanding subepidermal blistering diseases. J Invest Dermatol. 2010;130:1493-6 pubmed publisher
    Because hemidesmosomes and focal contacts (FCs) play major roles in epidermal wound healing and in the pathogenesis of subepidermal blistering diseases, it is of particular importance to understand their cross-talk in the regulation of ..
  71. Giordano G, Corradi D, Gnetti L, Melissari M. Intranodal myofibroblastoma: a case report and review of literature. Adv Clin Path. 2001;5:155-9, 161 pubmed
    ..We also review the literature in order to delineate the clinical and pathological features of this rare neoplasm...
  72. Kawasaki K, Kohno M, Inenaga C, Sato A, Hondo H, Miwa A, et al. Chordoid glioma of the third ventricle: a report of two cases, one with ultrastructural findings. Neuropathology. 2009;29:85-90 pubmed publisher
    ..Ultrastructural examination in one case revealed that the tumor cells were characterized by the presence of hemidesmosomes and associated focal basal lamina formation, intermediate junctions, microvilli and cilia, and intercellular ..