caveolae

Summary

Summary: Endocytic/exocytic CELL MEMBRANE STRUCTURES rich in glycosphingolipids, cholesterol, and lipid-anchored membrane proteins that function in ENDOCYTOSIS (potocytosis), transcytosis, and SIGNAL TRANSDUCTION. Caveolae assume various shapes from open pits to closed vesicles. Caveolar coats are composed of CAVEOLINS.

Top Publications

  1. Simons K, Gerl M. Revitalizing membrane rafts: new tools and insights. Nat Rev Mol Cell Biol. 2010;11:688-99 pubmed publisher
  2. Schlörmann W, Steiniger F, Richter W, Kaufmann R, Hause G, Lemke C, et al. The shape of caveolae is omega-like after glutaraldehyde fixation and cup-like after cryofixation. Histochem Cell Biol. 2010;133:223-8 pubmed publisher
    b>Caveolae were defined as flask- or omega-shaped plasma membrane invaginations, abundant in adipocytes, fibroblasts, endothelial and smooth muscle cells...
  3. Stoeber M, Stoeck I, Hänni C, Bleck C, Balistreri G, Helenius A. Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin. EMBO J. 2012;31:2350-64 pubmed publisher
    b>Caveolae are specialized domains present in the plasma membrane (PM) of most mammalian cell types. They function in signalling, membrane regulation, and endocytosis...
  4. Naota M, Shimada A, Morita T, Inoue K, Takano H. Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: possible association of diffusion and caveolae-mediated pinocytosis. Toxicol Pathol. 2009;37:456-62 pubmed publisher
    ..Electron microscopic analysis demonstrated an increased number of pinocytotic vesicles (caveolae) of various sizes in the type 1 alveolar epithelial cells (AEC) and endothelial cells; occasional caveolae ..
  5. Fu C, He J, Li C, Shyy J, Zhu Y. Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. Biochim Biophys Acta. 2010;1801:702-10 pubmed publisher
    b>Caveolae and its structural protein caveolin-1 (Cav-1) are abundant in vascular endothelial cells (ECs)...
  6. Huang W, Andras I, Rha G, Hennig B, Toborek M. PPAR? and PPAR? protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. FASEB J. 2011;25:3979-88 pubmed publisher
    ..in brain endothelial cells (hCMEC cell line) by attenuating cellular oxidative stress and down-regulation of caveolae-associated redox signaling...
  7. Wickström S, Lange A, Hess M, Polleux J, Spatz J, Kruger M, et al. Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell. 2010;19:574-88 pubmed publisher
    b>Caveolae are specialized compartments of the plasma membrane that are involved in signaling, endocytosis, and cholesterol transport...
  8. Yamamoto K, Furuya K, Nakamura M, Kobatake E, Sokabe M, Ando J. Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells. J Cell Sci. 2011;124:3477-83 pubmed publisher
    ..with siRNA and the depletion of plasma membrane cholesterol with methyl-?-cyclodexrin, indicating involvement of caveolae in localized ATP release...
  9. Russo A, Soh U, Paing M, Arora P, Trejo J. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A. 2009;106:6393-7 pubmed publisher
    ..These findings suggest that compartmentalization of PAR(1) in caveolae is critical for APC selective signaling to Rac1 activation and endothelial barrier protection...

More Information

Publications95

  1. Long M, Huang S, Wu C, Shackleford G, Jong A. Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells. J Biomed Sci. 2012;19:19 pubmed publisher
    ..However, the molecular mechanism of the interaction between Cryptococcus neoformans and HBMEC, relevant to its brain invasion, is still largely unknown...
  2. McMahon K, Zajicek H, Li W, Peyton M, Minna J, Hernandez V, et al. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J. 2009;28:1001-15 pubmed publisher
    b>Caveolae are a major membrane domain common to most cells. One of the defining features of this domain is the protein caveolin. The exact function of caveolin, however, is not clear...
  3. Dey K, Roy S, Ghosh B, Chakraborti S. Role of protein kinase C in phospholemman mediated regulation of ???? isozyme of Na?/K?-ATPase in caveolae of pulmonary artery smooth muscle cells. Biochimie. 2012;94:991-1000 pubmed publisher
    We have recently reported that ?(2)?(1) and ?(1)?(1) isozymes of Na(+)/K(+)-ATPase (NKA) are localized in the caveolae whereas only the ?(1)?(1) isozyme of NKA is localized in the non-caveolae fraction of pulmonary artery smooth muscle ..
  4. Sekimoto J, Kabayama K, Gohara K, Inokuchi J. Dissociation of the insulin receptor from caveolae during TNF?-induced insulin resistance and its recovery by D-PDMP. FEBS Lett. 2012;586:191-5 pubmed publisher
    ..Approximately 19% of IR molecules were detected in caveolar regions. The relative ratio of IRs associated with caveolae in TNF?-treated adipocytes was decreased to one-fifth of that in normal adipocytes, but this decrease was ..
  5. Feng L, Liao W, Luo Q, Zhang H, Wang W, Zheng J, et al. Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae. J Cell Physiol. 2012;227:2480-91 pubmed publisher
    ..Both AKT1 and ERK1/2 were co-fractionated with caveolin-1 and activated by FGF2 in the caveolae. Disruption of caveolae by methyl-?-cyclodextrin inhibited FGF2 activation of AKT1 and ERK1/2...
  6. Park E, Park M, Lee S, Li Y, Kim J, Lee J, et al. Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. J Pathol. 2009;218:337-49 pubmed publisher
    b>Caveolae (lipid rafts), microdomains of the plasma membrane, are known to contain various signalling molecules and consequently are involved in the regulation of many biological functions...
  7. Gould M, Williams G, Nicholson H. Changes in caveolae, caveolin, and polymerase 1 and transcript release factor (PTRF) expression in prostate cancer progression. Prostate. 2010;70:1609-21 pubmed publisher
    b>Caveolae are specialized invaginations in the cell membrane involved in the regulation of cell transport and signal transduction...
  8. Balijepalli R, Kamp T. Caveolae, ion channels and cardiac arrhythmias. Prog Biophys Mol Biol. 2008;98:149-60 pubmed publisher
    b>Caveolae are specialized membrane microdomains enriched in cholesterol and sphingolipids which are present in multiple cell types including cardiomyocytes...
  9. Oh P, Horner T, Witkiewicz H, Schnitzer J. Endothelin induces rapid, dynamin-mediated budding of endothelial caveolae rich in ET-B. J Biol Chem. 2012;287:17353-62 pubmed publisher
    ..b>Caveolae-mediated endocytosis of ligands and antibodies has been reported to be much slower in cell culture (?10 min)...
  10. Berger K, Lindh R, Wierup N, Zmuda Trzebiatowska E, Lindqvist A, Manganiello V, et al. Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism. PLoS ONE. 2009;4:e4671 pubmed publisher
    ..PDE3B was identified in caveolae, specific regions in the plasma membrane, and smooth endoplasmic reticulum...
  11. Noel J, Wang H, Hong N, Tao J, Yu K, Sorokina E, et al. PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol. 2013;305:L805-18 pubmed publisher
    ..We showed a role for KATP channel, caveolae (caveolin-1), and NADPH oxidase 2 (NOX2) in ROS production with stop of flow...
  12. Katsogiannou M, El Boustany C, Gackiere F, Delcourt P, Athias A, Mariot P, et al. Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells. PLoS ONE. 2009;4:e7068 pubmed publisher
    ..demonstrated the colocalization of the alpha(1A)-adrenoceptor with caveolin-1, the major protein component of caveolae. In addition, we showed that agonist stimulation of the alpha(1A)-adrenoceptor induced resistance to thapsigargin-..
  13. Song J, Kim M, Park S, Chen S, Pitson S, Lee H. Isoflurane via TGF-beta1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules. Am J Physiol Renal Physiol. 2010;298:F1041-50 pubmed publisher
    ..In this study, we tested the hypothesis that isoflurane, via TGF-beta1 release, increases caveolae formation in the buoyant fraction of the cell membrane of human renal proximal tubule (HK-2) cells to organize ..
  14. Boucrot E, Howes M, Kirchhausen T, Parton R. Redistribution of caveolae during mitosis. J Cell Sci. 2011;124:1965-72 pubmed publisher
    b>Caveolae form a specialized platform within the plasma membrane that is crucial for an array of important biological functions, ranging from signaling to endocytosis...
  15. Park E, Lee E, Lee S, Koo K, Sung J, Hwang E, et al. Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. Br J Pharmacol. 2010;160:1212-23 pubmed publisher
    Lipid rafts and caveolae are membrane microdomains with important roles in cell survival signalling involving the Akt pathway. Cholesterol is important for the structure and function of these microdomains...
  16. Feng X, Huang H, Yang Y, Fröhlich O, Klein J, Sands J, et al. Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane. Am J Physiol Renal Physiol. 2009;296:F1514-20 pubmed publisher
    ..Using sucrose gradient cell fractionation, we demonstrated that UT-A1 is concentrated in the caveolae-rich fraction both in stably expressing UT-A1 HEK293 cells and in freshly isolated kidney IMCD suspensions...
  17. Cheng Z, Singh R, Holicky E, Wheatley C, Marks D, Pagano R. Co-regulation of caveolar and Cdc42-dependent fluid phase endocytosis by phosphocaveolin-1. J Biol Chem. 2010;285:15119-25 pubmed publisher
    ..These data define a novel molecular mechanism for co-regulation of two distinct clathrin-independent endocytic pathways. ..
  18. Kiss A. Caveolae and the regulation of endocytosis. Adv Exp Med Biol. 2012;729:14-28 pubmed publisher
    ..extracellular ligands and plasma membrane components it has generally been accepted that other uptake mechanisms-caveolae-mediated and noncaveolar raft-dependent endocytosis-also exist...
  19. Jang J, Jeong J, Jun H, Lee S, Kim J, Kim Y, et al. A nucleic acid-hydrolyzing antibody penetrates into cells via caveolae-mediated endocytosis, localizes in the cytosol and exhibits cytotoxicity. Cell Mol Life Sci. 2009;66:1985-97 pubmed publisher
    ..The intracellular penetration of 3D8 scFv occurred by caveolae/lipid raft endocytosis...
  20. Xia T, Kovochich M, Liong M, Zink J, Nel A. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano. 2008;2:85-96 pubmed publisher
    ..Particles were taken up by caveolae, and their toxicity could be disrupted by cholesterol extraction from the surface membrane...
  21. Kumano Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S. Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Biochem Biophys Res Commun. 2013;434:594-9 pubmed publisher
    ..Here, we found that LOX-1 recognized and internalized ligands through the caveolae/raft-dependent endocytosis pathway in human coronary artery endothelial cells...
  22. Parat M. The biology of caveolae: achievements and perspectives. Int Rev Cell Mol Biol. 2009;273:117-62 pubmed publisher
    b>Caveolae are specialized plasma membrane subdomains visualized more than 50 years ago as cave-like invaginations at the cell surface. They are rich in cholesterol, glycosphingolipids, and lipid-anchored proteins...
  23. Lim J, Choy H, Park S, Han J, Jang I, Cho K. Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells. Aging Cell. 2010;9:243-51 pubmed publisher
    ..Here, we found that caveolae-dependent endocytosis is elevated in senescent cells...
  24. Lu T, Zhang D, Wang X, He T, Wang R, Chai Q, et al. Regulation of coronary arterial BK channels by caveolae-mediated angiotensin II signaling in diabetes mellitus. Circ Res. 2010;106:1164-73 pubmed publisher
    ..The aim in this study was to determine whether caveolae-targeting facilitates BK channel dysfunction in diabetic vessels...
  25. Rajab A, Straub V, McCann L, Seelow D, Varon R, Barresi R, et al. Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet. 2010;6:e1000874 pubmed publisher
    ..160delG, c.362dupT). PTRF-CAVIN is essential for caveolae biogenesis...
  26. Karbalaei M, Rippe C, Albinsson S, Ekman M, Mansten A, Uvelius B, et al. Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice. Eur J Pharmacol. 2012;689:179-85 pubmed publisher
    b>Caveolae are membrane invaginations present in a variety of cell types. Formation of caveolae depends on caveolins and on the more recently discovered family of proteins known as the cavins...
  27. Konkel M, Samuelson D, Eucker T, Shelden E, O Loughlin J. Invasion of epithelial cells by Campylobacter jejuni is independent of caveolae. Cell Commun Signal. 2013;11:100 pubmed publisher
    b>Caveolae are 25-100 nm flask-like membrane structures enriched in cholesterol and glycosphingolipids...
  28. González Muñoz E, Lopez Iglesias C, Calvo M, Palacin M, Zorzano A, Camps M. Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. Endocrinology. 2009;150:3493-502 pubmed publisher
    b>Caveolae are a specialized type of lipid rafts that are stabilized by oligomers of caveolin protein. Caveolae are particularly enriched in adipocytes...
  29. Pavlides S, Gutierrez Pajares J, Danilo C, Lisanti M, Frank P. Atherosclerosis, caveolae and caveolin-1. Adv Exp Med Biol. 2012;729:127-44 pubmed publisher
    ..b>Caveolae are 50-100 nm cell surface plasma membrane invaginations that are believed to play an important role in the ..
  30. Sun J, Kohr M, Nguyen T, Aponte A, Connelly P, Esfahani S, et al. Disruption of caveolae blocks ischemic preconditioning-mediated S-nitrosylation of mitochondrial proteins. Antioxid Redox Signal. 2012;16:45-56 pubmed publisher
    ..Mitochondria are key regulators of preconditioning, and most proteins showing an increase in SNO with IPC are mitochondrial. The aim of this study was to address how IPC transduces NO/SNO signaling to mitochondria in the heart...
  31. Guo Y, Golebiewska U, Scarlata S. Modulation of Ca²+ activity in cardiomyocytes through caveolae-G?q interactions. Biophys J. 2011;100:1599-607 pubmed publisher
    ..The plasma membranes of cardiomycoytes are rich in caveolae domains organized by caveolin proteins...
  32. Hayer A, Stoeber M, Bissig C, Helenius A. Biogenesis of caveolae: stepwise assembly of large caveolin and cavin complexes. Traffic. 2010;11:361-82 pubmed publisher
    We analyzed the assembly of caveolae in CV1 cells by following the fate of newly synthesized caveolin-1 (CAV1), caveolin-2 and polymerase I and transcript release factor (PTRF)/cavin-1 biochemically and using live-cell imaging...
  33. Layne J, Majkova Z, Smart E, Toborek M, Hennig B. Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases. J Nutr Biochem. 2011;22:807-11 pubmed publisher
    ..b>Caveolae are lipid raft microdomains abundant within the plasma membrane of endothelial cells and are responsible for ..
  34. Singh R, Marks D, Holicky E, Wheatley C, Kaptzan T, Sato S, et al. Gangliosides and beta1-integrin are required for caveolae and membrane domains. Traffic. 2010;11:348-60 pubmed publisher
    b>Caveolae are plasma membrane domains involved in the uptake of certain pathogens and toxins...
  35. Cavallo Medved D, Rudy D, Blum G, Bogyo M, Caglic D, Sloane B. Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res. 2009;315:1234-46 pubmed publisher
    ..cathepsin B and its cell surface binding partners, S100A/p11 (p11) of the annexin II heterotetramer (AIIt), to caveolae of human umbilical vein endothelial cells (HUVEC)...
  36. Hansen C, Shvets E, Howard G, Riento K, Nichols B. Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nat Commun. 2013;4:1831 pubmed publisher
    b>Caveolae are abundant in endothelial cells and are thought to have important roles in endothelial cell biology. The cavin proteins are key components of caveolae, and are expressed at varied amounts in different tissues...
  37. Huang H, Feng X, Zhuang J, Fröhlich O, Klein J, Cai H, et al. Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways. Am J Physiol Renal Physiol. 2010;299:F1389-95 pubmed publisher
    ..K44A causes UT-A1 protein accumulation in both the lipid raft and nonlipid raft pools, suggesting that both caveolae- and clathrin-mediated mechanisms may be involved in the internalization of UT-A1...
  38. Chidlow J, Sessa W. Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res. 2010;86:219-25 pubmed publisher
    b>Caveolae are specialized lipid rafts that form flask-shaped invaginations of the plasma membrane. They are involved in cell signalling and transport and have been shown critically regulate vascular reactivity and blood pressure...
  39. Shaikh S, Samanta K, Kar P, Roy S, Chakraborti T, Chakraborti S. m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle. Mol Cell Biochem. 2010;341:167-80 pubmed publisher
    ..we have identified two major bands corresponding to the 80 kDa large and the 28 kDa small subunit of m-calpain in caveolae vesicles isolated from bovine pulmonary artery smooth muscle plasma membrane...
  40. Nishikawa T, Iwakiri N, Kaneko Y, Taguchi A, Fukushima K, Mori H, et al. Nitric oxide release in human aortic endothelial cells mediated by delivery of amphiphilic polysiloxane nanoparticles to caveolae. Biomacromolecules. 2009;10:2074-85 pubmed publisher
    Microdomains such as lipid raft and caveolae are organized as functional compartments in plasma membrane of cells...
  41. Andras I, Eum S, Toborek M. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. Biochem Biophys Res Commun. 2012;421:177-83 pubmed publisher
    ..In the present study, we investigate the role of lipid rafts, functional caveolae, and caveolae-associated signaling in HIV-1-induced A? accumulation in HBMEC...
  42. Poisson C, Rollin S, Veronneau S, Bousquet S, Larrivée J, Le Gouill C, et al. Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. J Immunol. 2009;183:2747-57 pubmed publisher
    Certain proteins, including receptors and signaling molecules, are known to be enriched in caveolae and lipid rafts...
  43. Horikawa Y, Panneerselvam M, Kawaraguchi Y, Tsutsumi Y, Ali S, Balijepalli R, et al. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011;57:2273-83 pubmed publisher
    ..b>Caveolae, microdomains in the plasma membrane that contain caveolin proteins and natriuretic peptide receptors, have been ..
  44. Lim J, Clements M, Dobson J. Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis. PLoS ONE. 2012;7:e51350 pubmed publisher
    ..inhibitors, we established that these magnetic nanoparticle-nucleic acid complexes, moving across the cell surface under the influence of an oscillating magnet array, enters into the cells via the caveolae-mediated endocytic pathway.
  45. Moriyama T, Tsuruta Y, Shimizu A, Itabashi M, Takei T, Horita S, et al. The significance of caveolae in the glomeruli in glomerular disease. J Clin Pathol. 2011;64:504-9 pubmed publisher
    The aim of this study was to demonstrate expression of cell membrane invagination 'caveolae' in glomeruli and to correlate this with functional and structural characteristics of the human glomerular diseases.
  46. Naota M, Shimada A, Morita T, Yamamoto Y, Inoue K, Takano H. Caveolae-mediated endocytosis of intratracheally instilled gold colloid nanoparticles at the air-blood barrier in mice. Toxicol Pathol. 2013;41:487-96 pubmed publisher
    ..Electron microscopy revealed particles in the vesicles of macrophages, on the surface of AECs, and in caveolae-like vesicles in type 1 AECs...
  47. Massey K, Schnitzer J. Targeting and imaging signature caveolar molecules in lungs. Proc Am Thorac Soc. 2009;6:419-30 pubmed publisher
    ..To achieve these goals, distinct molecular signatures must be found for each organ or disease-state...
  48. Park M, Hennig B, Toborek M. Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae. J Cell Mol Med. 2012;16:362-75 pubmed publisher
    ..Because an active NOX complex is localized to caveolae, we next evaluated the role of caveolae in METH-mediated toxicity to brain endothelial cells...
  49. Hansen C, Nichols B. Exploring the caves: cavins, caveolins and caveolae. Trends Cell Biol. 2010;20:177-86 pubmed publisher
    b>Caveolae are ampullate (flask-shaped) invaginations that are abundant in the plasma membrane of many mammalian cell types...
  50. Sverdlov M, Shinin V, Place A, Castellon M, Minshall R. Filamin A regulates caveolae internalization and trafficking in endothelial cells. Mol Biol Cell. 2009;20:4531-40 pubmed publisher
    Transcytosis via caveolae is critical for maintaining vascular homeostasis by regulating the tissue delivery of macromolecules, hormones, and lipids...
  51. Sánchez Wandelmer J, Davalos A, Herrera E, Giera M, Cano S, de la Peña G, et al. Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes. Biochim Biophys Acta. 2009;1788:1731-9 pubmed publisher
    ..In the present work, we analyzed the effect of cholesterol biosynthesis inhibition on lipid raft/caveolae composition and functionality and assessed whether sterol precursors of cholesterol could substitute for ..
  52. Doherty G, McMahon H. Mechanisms of endocytosis. Annu Rev Biochem. 2009;78:857-902 pubmed publisher
    ..We also critically review the role of caveolae and caveolin1 in endocytosis...
  53. Fujita A, Cheng J, Tauchi Sato K, Takenawa T, Fujimoto T. A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique. Proc Natl Acad Sci U S A. 2009;106:9256-61 pubmed publisher
    ..By using this method, we found that PI(4,5)P(2) is highly concentrated at the rim of caveolae both in cultured fibroblasts and mouse smooth muscle cells in vivo...
  54. Ariotti N, Fernandez Rojo M, Zhou Y, Hill M, Rodkey T, Inder K, et al. Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. J Cell Biol. 2014;204:777-92 pubmed publisher
    The molecular mechanisms whereby caveolae exert control over cellular signaling have to date remained elusive. We have therefore explored the role caveolae play in modulating Ras signaling...
  55. Parat M, Riggins G. Caveolin-1, caveolae, and glioblastoma. Neuro Oncol. 2012;14:679-88 pubmed publisher
    ..Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells...
  56. Roth D, Patel H. Role of caveolae in cardiac protection. Pediatr Cardiol. 2011;32:329-33 pubmed publisher
    ..spatially organized complexes of signaling molecules in lipid-rich microdomains of the plasma membrane known as caveolae. Caveolins-proteins abundant in caveolae-provide a scaffold to organize, traffic, and regulate signaling ..
  57. Breen M, Camps M, Carvalho Simoes F, Zorzano A, Pilch P. Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. PLoS ONE. 2012;7:e34516 pubmed publisher
    b>Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity...
  58. Valentine C, Haggie P. Confinement of ?(1)- and ?(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae. Mol Biol Cell. 2011;22:2970-82 pubmed publisher
    ..In contrast, modulation of interactions between the putative scaffold caveolae and ?(2)AR did not alter receptor dynamics, suggesting that these membrane domains are not involved in ?(2)AR ..
  59. Liu C, Yu W, Chen Z, Zhang J, Zhang N. Enhanced gene transfection efficiency in CD13-positive vascular endothelial cells with targeted poly(lactic acid)-poly(ethylene glycol) nanoparticles through caveolae-mediated endocytosis. J Control Release. 2011;151:162-75 pubmed publisher
    ..The approach of introducing ligands that lead gene vectors to target caveolae-mediated endocytosis on nanoparticle surface might serve as a promising strategy for the effective gene ..
  60. Pilch P, Liu L. Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol Metab. 2011;22:318-24 pubmed publisher
    b>Caveolae are subdomains of the eukaryotic cell surface, so named because they resemble little caves, being small omega-shaped invaginations of the plasma membrane into the cytosol...
  61. Bai L, Deng X, Li J, Wang M, Li Q, An W, et al. Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res. 2011;21:1088-101 pubmed publisher
    ..release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts...
  62. Ramirez Sanchez I, Mendoza Lorenzo P, Zentella Dehesa A, Méndez Bolaina E, Lara Padilla E, Ceballos Reyes G, et al. Caveolae and non-caveolae lipid raft microdomains of human umbilical vein endothelial cells contain utrophin-associated protein complexes. Biochimie. 2012;94:1884-90 pubmed publisher
    ..Therefore, the aim of this study was to analyze the presence of the UAPC in caveolae and non-caveolae lipid rafts domains of HUVEC at baseline and with a mechanical stimulus...
  63. Mineo C, Shaul P. Regulation of eNOS in caveolae. Adv Exp Med Biol. 2012;729:51-62 pubmed publisher
    b>Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells...
  64. Lowalekar S, Cristofaro V, Radisavljevic Z, Yalla S, Sullivan M. Loss of bladder smooth muscle caveolae in the aging bladder. Neurourol Urodyn. 2012;31:586-92 pubmed publisher
    b>Caveolae are specialized regions of the cell membrane that modulate signal transduction and alterations in these structures affect bladder smooth muscle (BSM) contraction...
  65. Ogata T, Naito D, Nakanishi N, Hayashi Y, Taniguchi T, Miyagawa K, et al. MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by ?1-adrenergic receptors. Proc Natl Acad Sci U S A. 2014;111:3811-6 pubmed publisher
    ..In cardiomyocytes, ?1-ARs localize to flask-shaped membrane microdomains known as "caveolae." Caveolae require both caveolin and cavin proteins for their biogenesis and function...
  66. Bodor C, Nagy J, Vegh B, Nemeth A, Jenei A, Mirzahosseini S, et al. Angiotensin II increases the permeability and PV-1 expression of endothelial cells. Am J Physiol Cell Physiol. 2012;302:C267-76 pubmed publisher
    ..Endothelial cell surface was studied by atomic force microscopy (AFM), and caveolae were visualized by transmission electron microscopy (TEM) in HUVEC monolayers...
  67. Zhang Y, Peng F, Gao B, Ingram A, Krepinsky J. High glucose-induced RhoA activation requires caveolae and PKC?1-mediated ROS generation. Am J Physiol Renal Physiol. 2012;302:F159-72 pubmed publisher
    ..RhoA and some PKC isoforms localize to caveolae. Chemical disruption of these microdomains prevented RhoA and PKC?1 activation by glucose...
  68. Bawa R, Fung S, Shiozaki A, Yang H, Zheng G, Keshavjee S, et al. Self-assembling peptide-based nanoparticles enhance cellular delivery of the hydrophobic anticancer drug ellipticine through caveolae-dependent endocytosis. Nanomedicine. 2012;8:647-54 pubmed publisher
    ..Such enhanced uptake was significantly reduced by inhibitors specifically for the caveolae-dependent pathway. We also found both protonated and neutral forms of EPT present in the cells...
  69. Fagerholm S, Ortegren U, Karlsson M, Ruishalme I, Stralfors P. Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. PLoS ONE. 2009;4:e5985 pubmed publisher
    The insulin receptor is localized in caveolae and is dependent on caveolae or cholesterol for signaling in adipocytes. When stimulated with insulin, the receptor is internalized.
  70. Harvey R, Calaghan S. Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology. J Mol Cell Cardiol. 2012;52:366-75 pubmed publisher
    ..One such structure is the caveola, a flask-shaped lipid raft. Caveolae are well-recognised as signalosomes, platforms for assembly of signalling complexes of receptors, effectors and ..
  71. Orlichenko L, Weller S, Cao H, Krueger E, Awoniyi M, Beznoussenko G, et al. Caveolae mediate growth factor-induced disassembly of adherens junctions to support tumor cell dissociation. Mol Biol Cell. 2009;20:4140-52 pubmed publisher
    ..the integrity of tumor cell-cell contacts is disrupted after epidermal growth factor (EGF) stimulation through caveolae-mediated endocytosis of the adherens junction protein E-cadherin...
  72. Agarwal S, MacDougall D, Tyser R, Pugh S, Calaghan S, Harvey R. Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes. J Mol Cell Cardiol. 2011;50:500-9 pubmed publisher
    ..They also suggest that ?(1)AR regulation of myocyte contraction involves the local production of cAMP by a subpopulation of receptors associated with caveolar lipid rafts...
  73. Schwarzer S, Nobles M, Tinker A. Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels?. J Biol Chem. 2010;285:27817-26 pubmed publisher
    ..An appealing hypothesis would be if components were sequestered in membrane domains such as caveolae/rafts...
  74. Majkova Z, Toborek M, Hennig B. The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants. J Cell Mol Med. 2010;14:2359-70 pubmed publisher
    ..Lipid rafts, and especially caveolae, are enriched in endothelial cells, and down-regulation of the caveolin-1 gene may provide protection against the ..
  75. Thurn K, Arora H, Paunesku T, Wu A, Brown E, Doty C, et al. Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells. Nanomedicine. 2011;7:123-30 pubmed publisher
  76. Kiss A, Botos E. Endocytosis via caveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation?. J Cell Mol Med. 2009;13:1228-37 pubmed publisher
    ..mechanisms, including phagocytosis, macropinocytosis, clathrin-dependent and clathrin-independent uptake such as caveolae-mediated and non-caveolar raft-dependent endocytosis...
  77. Kanai Y, Wang D, Hirokawa N. KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J Cell Biol. 2014;204:395-408 pubmed publisher
    ..Exogenous KIF13B, initially localized on the plasma membrane with caveolae, was translocated to the vesicles in the cytoplasm with LRP1 and caveolin-1...
  78. Lee S, Koo K, Park J, Kim H, Ye S, Park J, et al. HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress. Carcinogenesis. 2009;30:1997-2004 pubmed publisher
  79. Lebbink M, Jimenez N, Vocking K, Hekking L, Verkleij A, Post J. Spiral coating of the endothelial caveolar membranes as revealed by electron tomography and template matching. Traffic. 2010;11:138-50 pubmed publisher
    b>Caveolae are invaginations of the plasma membrane involved in multiple cellular processes, including transcytosis. In this paper we present an extensive 3-D electron tomographic study of the endothelial caveolar system in situ...
  80. Buitrago C, Boland R. Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells. J Steroid Biochem Mol Biol. 2010;121:169-75 pubmed publisher
    ..In this work, we investigated the role of caveolae and caveolin-1 (cav-1) in 1alpha,25(OH)2D3-stimulation of c-Src and MAPKs...
  81. Oshikawa J, Urao N, Kim H, Kaplan N, Razvi M, McKinney R, et al. Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice. PLoS ONE. 2010;5:e10189 pubmed publisher
    ..Mechanistically, VEGF-induced VEGFR2-pY in caveolae/lipid rafts, but non-lipid rafts, is enhanced by ecSOD, which localizes at lipid rafts via HBD...
  82. Jelinek D, Maghsoodi B, Borbon I, Hardwick R, Cherrington N, Erickson R. Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolae. Gene. 2012;491:128-34 pubmed publisher
    ..We have addressed the possible role of caveolae in these differences...
  83. Hippe H, Wolf N, Abu Taha H, Lutz S, Le Lay S, Just S, et al. Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:461-72 pubmed publisher
    b>Caveolae are flask-shaped invaginations in the plasma membrane that serve to compartmentalize and organize signal transduction processes, including signals mediated by G protein-coupled receptors and heterotrimeric G proteins...
  84. Hansen C, Howard G, Nichols B. Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. J Cell Sci. 2011;124:2777-85 pubmed publisher
    ..We go on to report that GFP-pacsin 2 can be recruited to caveolae, and that endogenous pacsin 2 partially colocalises with caveolin 1 at the plasma membrane...
  85. Reeves V, THOMAS C, Smart E. Lipid rafts, caveolae and GPI-linked proteins. Adv Exp Med Biol. 2012;729:3-13 pubmed publisher
    Lipid rafts and caveolae are specialized membrane microdomains enriched in sphingolipids and cholesterol...
  86. Muriel O, Echarri A, Hellriegel C, Pavón D, Beccari L, Del Pozo M. Phosphorylated filamin A regulates actin-linked caveolae dynamics. J Cell Sci. 2011;124:2763-76 pubmed publisher
    b>Caveolae are relatively stable membrane invaginations that compartmentalize signaling, regulate lipid metabolism and mediate viral entry. Caveolae are closely associated with actin fibers and internalize in response to diverse stimuli...