cell matrix junctions


Summary: Specialized areas at the CELL MEMBRANE where a cell attaches to the EXTRACELLULAR MATRIX or other substratum.

Top Publications

  1. Zamir E, Geiger B. Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci. 2001;114:3583-90 pubmed
    ..These changes are driven by mechanical force generated by the actin- and myosin-containing contractile machinery of the cells, or by external forces applied to the cells, and regulated by matrix rigidity...
  2. Zaidel Bar R, Itzkovitz S, Ma ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007;9:858-67 pubmed
    ..We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions...
  3. Chan W, Goldberg H, Hunter G, Dixon S, Rizkalla A. Modification of polymer networks with bone sialoprotein promotes cell attachment and spreading. J Biomed Mater Res A. 2010;94:945-52 pubmed publisher
    ..Thus, BSP-immobilization may be a useful strategy for optimizing scaffolds for skeletal tissue engineering. ..
  4. Xu L, Wang W, Meng T, Ma L, Tong L, Shen J, et al. New microtubulin inhibitor MT189 suppresses angiogenesis via the JNK-VEGF/VEGFR2 signaling axis. Cancer Lett. 2018;416:57-65 pubmed publisher
    ..Together with our previous report showing that MT189 exhibited anticancer activity via the JNK-MCL-1 pathway, these new findings further support MT189-based drug development for cancer therapy. ..
  5. Symowicz J, Adley B, Gleason K, Johnson J, Ghosh S, Fishman D, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 2007;67:2030-9 pubmed
    ..These data support a novel mechanism for posttranslational modification of E-cadherin function via MMP-9 induction initiated by cell-matrix contact and suggest a mechanism for promotion of EOC metastatic dissemination. ..
  6. Hatakeyama S, Hayashi S, Yoshida Y, Otsubo A, Yoshimoto K, Oikawa Y, et al. Retinoic acid disintegrated desmosomes and hemidesmosomes in stratified oral keratinocytes. J Oral Pathol Med. 2004;33:622-8 pubmed
    ..The effects of all-trans RA on cell-cell and cell-matrix connections of gingival epithelial (GE)1 cells in a multilayered culture were investigated...
  7. Bian G, Cao G, Lv X, Li Q, Sun H, Xiao Y, et al. Down-regulation of Pkd2 by siRNAs suppresses cell-cell adhesion in the mouse melanoma cells. Mol Biol Rep. 2010;37:2387-95 pubmed publisher
    ..Collectively, these findings for the first time showed that PC-2 may mediate cell-cell adhesion, at least partially, through E-cadherin. ..
  8. Zheng J, Han S, Chiu Y, Yip A, Boichat N, Zhu S, et al. Epithelial Monolayers Coalesce on a Viscoelastic Substrate through Redistribution of Vinculin. Biophys J. 2017;113:1585-1598 pubmed publisher
    ..Our results implicate vinculin translocation in a molecular switching mechanism that senses substrate viscoelasticity and associates with actomyosin contractility. ..
  9. Holt M, Calle Y, Sutton D, Critchley D, Jones G, Dunn G. Quantifying cell-matrix adhesion dynamics in living cells using interference reflection microscopy. J Microsc. 2008;232:73-81 pubmed publisher
    ..This method is also useful for studying the rapid dynamics of podosomes as observed in primary mouse dendritic cells. ..

More Information


  1. Watson A, Morris V, Chan B. Coordinated integrin and growth factor regulation of primary keratinocyte migration mediated through extracellular signal regulated kinase and phosphoinositide 3-kinase. Arch Dermatol Res. 2009;301:307-17 pubmed publisher
    ..Thus beta1 integrins acted in concert with EGF and HGF to regulate migration of primary keratinocytes on extracellular matrix components via PI3K and MEK/ERK. ..
  2. Samarin S, Koch S, Ivanov A, Parkos C, Nusrat A. Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. Biochem Biophys Res Commun. 2010;391:394-400 pubmed publisher
    ..Thus, our findings provide the first evidence that Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion. ..
  3. Sweet D, Tzima E. Spatial signaling networks converge at the adaptor protein Shc. Cell Cycle. 2009;8:231-5 pubmed
    ..Recent studies suggest that several signaling networks coalesce at the adaptor protein Shc. ..
  4. Guerrero B, Finol H, Reyes Lugo M, Salazar A, Sanchez E, Estrella A, et al. Activities against hemostatic proteins and adrenal gland ultrastructural changes caused by the brown widow spider Latrodectus geometricus (Araneae: Theridiidae) venom. Comp Biochem Physiol C Toxicol Pharmacol. 2010;151:113-21 pubmed publisher
    ..geometricus VGH. The venom of this spider could be inducing hemostatic system damages on envenomed patients. ..
  5. Nakano N, Nakao A, Ishidoh K, Tsuboi R, Kominami E, Okumura K, et al. CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. Br J Dermatol. 2005;153:37-45 pubmed
    ..Furthermore, reduced expression of CDK5/p35 in the epidermis might be involved in the pathogenesis of psoriasis. ..
  6. Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol. 2001;159:875-83 pubmed
    ..We suggest that Jagged regulation of cell-cell and cell-matrix interactions may contribute to the control of cell migration in situations of tissue remodeling in vivo. ..
  7. Kato A, Nakamura K, Kudo H, Tran Y, Yamamoto Y, Doi H, et al. Characterization of the column and autocellular junctions that define the vasculature of gill lamellae. J Histochem Cytochem. 2007;55:941-53 pubmed
    ..This study represents the first molecular characterization and fluorescence visualization of the column and autocellular junctions involved in both maintaining structural integrity and the hemodynamics of the branchial lamellae. ..
  8. Hui D. A no-no for NonO and JNK in extracellular matrix homeostasis and vascular stability. Arterioscler Thromb Vasc Biol. 2007;27:1677-8 pubmed
  9. Sottile J, Hocking D. Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell. 2002;13:3546-59 pubmed
  10. Auxenfans C, Builles N, Andre V, Lequeux C, Fievet A, Rose S, et al. [Porous matrix and primary-cell culture: a shared concept for skin and cornea tissue engineering]. Pathol Biol (Paris). 2009;57:290-8 pubmed publisher
  11. Berrier A, Yamada K. Cell-matrix adhesion. J Cell Physiol. 2007;213:565-73 pubmed
    ..The review concludes by speculating on the application of this knowledge of cell-matrix interactions in the formation of cell adhesions, assembly of matrix, migration, and tumorigenesis to potential future therapeutic approaches. ..
  12. Bershadsky A, Kozlov M, Geiger B. Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Curr Opin Cell Biol. 2006;18:472-81 pubmed
    ..Theoretical models have also been used to address the physical mechanisms underlying adhesion-mediated mechanosensing. ..
  13. Jiang H, Grinnell F. Cell-matrix entanglement and mechanical anchorage of fibroblasts in three-dimensional collagen matrices. Mol Biol Cell. 2005;16:5070-6 pubmed
    ..We suggest that cell-matrix entanglement represents a novel mechanism of cell anchorage that uniquely depends on the three-dimensional character of the matrix. ..
  14. Mierke C. The role of vinculin in the regulation of the mechanical properties of cells. Cell Biochem Biophys. 2009;53:115-26 pubmed publisher
    ..Measurements of cell's biophysical properties will be presented. In summary, vinculin's leading role among focal adhesion proteins in regulating the mechanical properties of cells will be discussed. ..
  15. Santoro G, Romeo C, Impellizzeri P, Cutroneo G, Micali A, Trimarchi F, et al. Immunofluorescence distribution of actin-associated proteins in human seminiferous tubules of adolescent testes, normal and pathologic. J Endocrinol Invest. 2000;23:369-75 pubmed
    ..Varicocele alters the patterns of these two proteins both quantitatively and qualitatively. ..
  16. Klose A, Wilbrand Hennes A, Zigrino P, Weber E, Krieg T, Mauch C, et al. Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B. Int J Cancer. 2006;118:2735-43 pubmed
    ..These results strongly implicate a pivotal role of cell-matrix interactions for the regulation of cathepsin B localization and activity in melanoma cells. ..
  17. Lin E, Hui A, Meens J, Tremblay E, Schaefer E, Elliott B. Disruption of Ca2+-dependent cell-matrix adhesion enhances c-Src kinase activity, but causes dissociation of the c-Src/FAK complex and dephosphorylation of tyrosine-577 of FAK in carcinoma cells. Exp Cell Res. 2004;293:1-13 pubmed
    ..These findings indicate an important role of integrin-based cell-matrix adhesion in regulating c-Src/FAK signaling under decreased anchorage conditions. ..
  18. Iacobas D, Urban M, Iacobas S, Spray D. Transcriptomic characterization of four classes of cell-cell/cell-matrix genes in brains and hearts of wild type and connexin43 null mice. Rom J Physiol. 2002;39-40:91-116 pubmed
  19. Zamir E, Geiger B, Kam Z. Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions. PLoS ONE. 2008;3:e1901 pubmed publisher
    ..We propose that compositional imaging can serve as a powerful tool for studying complex multi-molecular assemblies in cells and for mapping their distribution at sub-micron resolution. ..
  20. Di Mauro D, Gaeta R, Arco A, Milardi D, Lentini S, Runci M, et al. Distribution of costameric proteins in normal human ventricular and atrial cardiac muscle. Folia Histochem Cytobiol. 2009;47:605-8 pubmed publisher
    ..Moreover, our data showed that all tested proteins colocalize between each other. ..
  21. Larjava H, Plow E, Wu C. Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep. 2008;9:1203-8 pubmed publisher
    ..It is therefore clear that kindlins, together with several other integrin-proximal proteins, are essential for integrin signalling and cell-ECM adhesion regulation. ..
  22. Erdmann T, Schwarz U. Bistability of cell-matrix adhesions resulting from nonlinear receptor-ligand dynamics. Biophys J. 2006;91:L60-2 pubmed
    ..For small cell-matrix adhesions, we find rapid switching between unbound and bound states, which in the initial stages of adhesion allows the cell to explore its environment through many transient adhesions. ..
  23. Nagafuchi A. [Structure and function of cadherin-catenin complex]. Seikagaku. 2006;78:579-87 pubmed
  24. Boulter E, Van Obberghen Schilling E. Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization. Eur J Cell Biol. 2006;85:255-63 pubmed
    ..Both gain- and loss-of-function approaches to study ILK have confirmed the essential role of this protein in regulating cell-matrix adhesion dynamics and cytoskeletal organization...
  25. Kabukcuoglu S, Oner U, Ozalp S, Bildirici K, Yalcin O, Colak E. The role of actin bundling protein fascin in the progression of ovarian neoplasms. Eur J Gynaecol Oncol. 2006;27:171-6 pubmed
    ..The aim of the study was to investigate the role of fascin in tumor progression and to investigate the role of fascin on endothelial cell migration and angiogenesis in ovarian neoplasms...
  26. Ohnishi Y, Sakumi K, Yamazaki K, Ohnishi Y, Miura T, Tominaga Y, et al. Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008;19:4717-29 pubmed publisher
    ..We thus concluded that FosB and DeltaFosB/Delta2DeltaFosB use this pathway to antagonistically regulate cell matrix adhesion...
  27. Yamazaki Y, Okawa K, Yano T, Tsukita S, Tsukita S. Optimized proteomic analysis on gels of cell-cell adhering junctional membrane proteins. Biochemistry. 2008;47:5378-86 pubmed publisher
  28. Larsen M, Tremblay M, Yamada K. Phosphatases in cell-matrix adhesion and migration. Nat Rev Mol Cell Biol. 2003;4:700-11 pubmed
  29. Faurobert E, Albiges Rizo C. Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction. FEBS J. 2010;277:1084-96 pubmed publisher
    ..We focus on the best-characterized partners and review data on the signaling pathways they regulate as a step towards a better understanding of the etiology of CCM disease...
  30. Hartmann C, Zozulya A, Wegener J, Galla H. The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study. Exp Cell Res. 2007;313:1318-25 pubmed
    ..Our observations indicate that glia-derived ECM - as an essential part of the BBB - is required to ensure proper barrier formation of cerebral endothelial cells...
  31. Hervy M, Hoffman L, Beckerle M. From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol. 2006;18:524-32 pubmed
    ..Recent findings have given insight into the physiological signals that trigger trafficking of focal adhesion constituents to the nucleus, where they make diverse contributions to the control of gene expression...
  32. Linder S, Kopp P. Podosomes at a glance. J Cell Sci. 2005;118:2079-82 pubmed
  33. Wipff P, Hinz B. Myofibroblasts work best under stress. J Bodyw Mov Ther. 2009;13:121-7 pubmed publisher
    ..From these findings it emerges that the specific matrix adhesion structures of myofibroblasts are promising targets to modulate myofibroblast differentiation and activity...
  34. Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, et al. Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol. 2004;165:893-902 pubmed
    ..The spatio-temporal regulation of two independent signaling pathways for CD44 cleavage plays a crucial role in cell-matrix interaction and cell migration...
  35. Asparuhova M, Gelman L, Chiquet M. Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress. Scand J Med Sci Sports. 2009;19:490-9 pubmed publisher
    ..We describe examples of genes that are regulated by mechanical stress in a manner depending on actin dynamics, among them the ECM protein, tenascin-C...
  36. Buda A, Qualtrough D, Jepson M, Martines D, Paraskeva C, Pignatelli M. Butyrate downregulates alpha2beta1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines. Gut. 2003;52:729-34 pubmed
    ..In colonic epithelial cells, alpha(2)beta(1) integrin controls glandular differentiation and proliferation. Butyrate stimulates differentiation and induces apoptosis in vitro...
  37. Machuca E, Benoit G, Antignac C. Genetics of nephrotic syndrome: connecting molecular genetics to podocyte physiology. Hum Mol Genet. 2009;18:R185-94 pubmed publisher
    ..This review will focus on recent molecular and clinical findings in the field of genetics of NS, thereby providing a better understanding of the complex glomerular filtration barrier physiology...
  38. Akisaka T, Yoshida H, Suzuki R, Takama K. Adhesion structures and their cytoskeleton-membrane interactions at podosomes of osteoclasts in culture. Cell Tissue Res. 2008;331:625-41 pubmed
    ..Thus, the clathrin plaques on the ventral membrane of osteoclasts might be involved in both cell adhesion and the formation of receptor-ligand complexes, i.e., endocytosis...
  39. Sparrow J, Schock F. The initial steps of myofibril assembly: integrins pave the way. Nat Rev Mol Cell Biol. 2009;10:293-8 pubmed publisher
    ..We propose a model of integrin-dependent cell-matrix adhesion as the starting point for myofibrillogenesis...
  40. Huang S, Liu X, Bai C, Lu F, Yuan Y, Gong D, et al. Synergistic effect of fibronectin and hepatocyte growth factor on stable cell-matrix adhesion, re-endothelialization, and reconstitution in developing tissue-engineered heart valves. Heart Vessels. 2007;22:116-22 pubmed
    ..6/mm) remained high under exposure to high flow and pressure conditions in a bioreactor. These results demonstrated that the combination of fibronectin and hepatocyte growth factor contributed to creating autologous living heart valve...
  41. McLaughlin M, Bromfield J, Albertini D, Telfer E. Activin promotes follicular integrity and oogenesis in cultured pre-antral bovine follicles. Mol Hum Reprod. 2010;16:644-53 pubmed publisher
    ..Thus, the polarized expression of cell contact interactions promoted by activin supports ongoing folliculogenesis...
  42. Hiscox S, Morgan L, Green T, Nicholson R. Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer. Endocr Relat Cancer. 2006;13 Suppl 1:S53-9 pubmed
  43. Chattopadhyay A, Carpenter G. PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion. J Cell Sci. 2002;115:2233-9 pubmed
    ..Lastly, the data demonstrate that insulinlike growth factor stimulated tyrosine phosphorylation of phospholipase C-gamma1 in both adherent and suspension cells...
  44. Jones R, Avizienyte E, Wyke A, Owens D, Brunton V, Frame M. Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. Br J Cancer. 2002;87:1128-35 pubmed
  45. Schock F, Perrimon N. Retraction of the Drosophila germ band requires cell-matrix interaction. Genes Dev. 2003;17:597-602 pubmed
    ..We further implicate a role for this spreading in the process of germ-band retraction...
  46. Dickson G, Buchanan F, Marsh D, Harkin Jones E, Little U, McCaigue M. Orthopaedic tissue engineering and bone regeneration. Technol Health Care. 2007;15:57-67 pubmed
    ..Innovative solutions are required to address this and other issues such as the biocompatibility of material surfaces and the use of appropriate scaffold topography and porosity to influence bone cell gene expression...
  47. Alexander J, Zhu Y, Elrod J, Alexander B, Coe L, Kalogeris T, et al. Reciprocal regulation of endothelial substrate adhesion and barrier function. Microcirculation. 2001;8:389-401 pubmed
    ..To examine how cell-substrate adhesion is regulated during barrier changes produced by exposure to inflammatory mediators...
  48. Harris T, Kalogeropoulos S, Nguyen T, Liu S, Bartis J, Ellars C, et al. Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy. Cancer Biother Radiopharm. 2003;18:627-41 pubmed
    ..Tumors are visible as early as 0.5 hours PI. Radiotherapy studies in the c-neu Oncomouse model demonstrated a slowing of tumor growth at a dose of 15 mCi/m(2), and a regression of tumors at a dose of 90 mCi/m(2)...
  49. Hinz B, Gabbiani G. Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling. Thromb Haemost. 2003;90:993-1002 pubmed
  50. Carlson M, Thompson J. Wound matrix attachment regulates actin content and organization in cells of the granulation tissue. Wound Repair Regen. 2005;13:84-92 pubmed
    ..Our data support the concept that the state of wound matrix attachment regulates the actin cytoskeleton of wound cells...
  51. Eichler M, Carlson M. Modeling dermal granulation tissue with the linear fibroblast-populated collagen matrix: a comparison with the round matrix model. J Dermatol Sci. 2006;41:97-108 pubmed
    ..Interestingly, the round fibroblast-populated collagen matrix has been used as a model of wound contraction, even though contraction in this model is mostly symmetrical...
  52. Hernández M, Sala M, Balsamo J, Lilien J, Arregui C. ER-bound PTP1B is targeted to newly forming cell-matrix adhesions. J Cell Sci. 2006;119:1233-43 pubmed
    ..Our results suggest that PTP1B targets to immature cell-matrix foci in newly forming lamellae by dynamic extensions of the ER and contributes to the maturation of these sites...
  53. Erdmann T, Schwarz U. Impact of receptor-ligand distance on adhesion cluster stability. Eur Phys J E Soft Matter. 2007;22:123-37 pubmed
    ..For small cluster sizes, stochastic effects destabilize the clusters at large separation, as shown by a detailed analysis of the stochastic potential resulting from the Fokker-Planck equation...
  54. Farrell E, Byrne E, Fischer J, O Brien F, O Connell B, Prendergast P, et al. A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds. Technol Health Care. 2007;15:19-31 pubmed
    ..Furthermore, it was shown that complete scaffold mineralisation could be evoked within a 6 week timeframe. This study further demonstrates the potential use of MSC-seeded collagen GAG scaffolds for bone tissue engineering applications...
  55. Zhang M, Liu J, Cheng A, Deyoung S, Chen X, Dold L, et al. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006;25:5284-93 pubmed
    ..Taken together, these results indicate that CAP is a cytoskeletal adaptor protein involved in modulating adhesion-mediated signaling events that lead to cell migration...
  56. Le Clainche C, Carlier M. Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev. 2008;88:489-513 pubmed publisher
    ..III) focuses on the function and the regulation of major proteins (vinculin, talin, tensin, and alpha-actinin) that control the nucleation, the binding, and the barbed-end growth of actin filaments in adhesions...
  57. Hagg P, Väisänen T, Tuomisto A, Rehn M, Tu H, Huhtala P, et al. Type XIII collagen: a novel cell adhesion component present in a range of cell-matrix adhesions and in the intercalated discs between cardiac muscle cells. Matrix Biol. 2001;19:727-42 pubmed
    ..Taken together, the results strongly suggest that type XIII collagen has a cell adhesion-associated function in a wide array of cell-matrix junctions...
  58. Poullet P, Gautreau A, Kadaré G, Girault J, Louvard D, Arpin M. Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion. J Biol Chem. 2001;276:37686-91 pubmed
    ..Altogether, these observations indicate that ezrin is able to trigger FAK activation in signaling events that are not elicited by cell-matrix adhesion...
  59. O Brien F, Harley B, Waller M, Yannas I, Gibson L, Prendergast P. The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering. Technol Health Care. 2007;15:3-17 pubmed
  60. Pompe T, Keller K, Mothes G, Nitschke M, Teese M, Zimmermann R, et al. Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion. Biomaterials. 2007;28:28-37 pubmed
    ..In line with earlier studies referring to different materials cell adhesion and matrix reorganisation were shown to be sensitively controlled through the physicochemical profile of poly(hydroxybutyrate) surfaces...
  61. Evanko S, Tammi M, Tammi R, Wight T. Hyaluronan-dependent pericellular matrix. Adv Drug Deliv Rev. 2007;59:1351-65 pubmed
    ..The importance of the pericellular matrix in cellular mechanotransduction and the response to mechanical strain are also discussed...
  62. Tabata T, McDonagh S, Kawakatsu H, Pereira L. Cytotrophoblasts infected with a pathogenic human cytomegalovirus strain dysregulate cell-matrix and cell-cell adhesion molecules: a quantitative analysis. Placenta. 2007;28:527-37 pubmed
    ..CMV replication in late gestation placentas with considerable reserves could deplete cytotrophoblast progenitors, thereby impairing syncytiotrophoblast development and increasing the risk of virus transmission to fetal blood vessels...
  63. Chen X, Gumbiner B. Crosstalk between different adhesion molecules. Curr Opin Cell Biol. 2006;18:572-8 pubmed
    ..Furthermore, protocadherins can interact with extracellular matrix proteins or function by regulating classical cadherins...
  64. Shroff H, White H, Betzig E. Photoactivated localization microscopy (PALM) of adhesion complexes. Curr Protoc Cell Biol. 2008;Chapter 4:Unit 4.21 pubmed publisher
    ..A particular emphasis is placed on the instrumentation and photoactivatable fluorescent protein (PA-FP) tags necessary to achieve PALM images at approximately 20 nm resolution in 5 to 30 min in fixed cells...
  65. Miranti C. Controlling cell surface dynamics and signaling: how CD82/KAI1 suppresses metastasis. Cell Signal. 2009;21:196-211 pubmed publisher
  66. Treiber N, Peters T, Sindrilaru A, Huber R, Kohn M, Menke A, et al. Overexpression of manganese superoxide dismutase in human dermal fibroblasts enhances the contraction of free floating collagen lattice: implications for ageing and hyperplastic scar formation. Arch Dermatol Res. 2009;301:273-87 pubmed publisher
    ..Collectively, these data suggest that H2O2 or other hydroperoxides or peroxynitrite or a combination thereof may function as important second messengers in collagen lattice contraction and act at least in part via TGF-beta1 activation...
  67. Larouche D, Lavoie A, Proulx S, Paquet C, Carrier P, Beauparlant A, et al. [Regenerative medicine: stem cells, cellular and matricial interactions in the reconstruction of skin and cornea by tissue engineering]. Pathol Biol (Paris). 2009;57:299-308 pubmed publisher
  68. Wiesner S, Lange A, Fassler R. Local call: from integrins to actin assembly. Trends Cell Biol. 2006;16:327-9 pubmed
    ..In an exciting publication, Butler et al. have demonstrated for the first time that purified adhesion complexes possess the entire machinery necessary to actively assemble F-actin as a function of integrin activity and clustering...
  69. Al Ayoubi A, Tarcsafalvi A, Zheng H, Sakati W, Eblen S. ERK activation and nuclear signaling induced by the loss of cell/matrix adhesion stimulates anchorage-independent growth of ovarian cancer cells. J Cell Biochem. 2008;105:875-84 pubmed publisher
    ..These data demonstrate a unique regulation of ERK by cellular adhesion and suggest a mechanism by which ERK may regulate anchorage-independent growth of metastatic ovarian cancer cells...
  70. Bai C, Ohsugi M, Abe Y, Yamamoto T. ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. J Cell Sci. 2007;120:2828-37 pubmed
    ..Taken together, we conclude that that ZRP-1 plays a crucial role in coupling the cell-matrix/cell-cell-contact signals with Rho GTPase-mediated actin remodeling by localizing at cell-matrix and cell-cell contact sites...
  71. Guezguez B, Vigneron P, Alais S, Jaffredo T, Gavard J, Mège R, et al. A dileucine motif targets MCAM-l cell adhesion molecule to the basolateral membrane in MDCK cells. FEBS Lett. 2006;580:3649-56 pubmed
    ..Although double labelling experiments showed that MCAM-l is not a component of adherens junctions and focal adhesions, its expression on basolateral membranes suggests that MCAM-l is involved in epithelium insuring...
  72. Wang X, Lin S, Li J, Kemmner W, Ding Y. [Effect of cell surface sialic acid and their linkages on adhesion of mammary carcinoma cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2006;26:742-6 pubmed
    ..To investigate the effect of cell surface sialic acid and its linkage on the cell-cell and cell-matrix adhesion of mammary carcinoma cells MD-MB-435...
  73. Gunst S, Zhang W. Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol. 2008;295:C576-87 pubmed publisher
    ..Better understanding of the physiological function of these dynamic cytoskeletal processes in smooth muscle may provide important insights into the physiological regulation of smooth muscle tissues...
  74. Arthur W, Noren N, Burridge K. Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol Res. 2002;35:239-46 pubmed
  75. Boraldi F, Croce M, Quaglino D, Sammarco R, Carnevali E, Tiozzo R, et al. Cell-matrix interactions of in vitro human skin fibroblasts upon addition of hyaluronan. Tissue Cell. 2003;35:37-45 pubmed
    ..A role of HA in cell orientation could be relevant for the deposition of collagen fibrils in regeneration and tissue remodelling...
  76. Ferguson J, Thoma B, Mikesh M, Kramer R, Bennett K, Purchio A, et al. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003;313:93-105 pubmed
  77. Fiedler L, Eble J. Decorin regulates endothelial cell-matrix interactions during angiogenesis. Cell Adh Migr. 2009;3:3-6 pubmed
    ..This data will be discussed in conjunction with findings from previous studies, to better understand the role of this proteoglycan in angiogenesis...
  78. Adams J. Molecular organisation of cell-matrix contacts: essential multiprotein assemblies in cell and tissue function. Expert Rev Mol Med. 2002;4:1-24 pubmed
  79. Cheema Z, Santillano D, Wade S, Newman J, Miranda R. The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins. BMC Neurosci. 2004;5:11 pubmed
    ..Therefore, in the following studies, we sought to identify developmentally relevant cell biological processes that regulate cell-surface Fas expression and reciprocal consequences of Fas receptor activation...
  80. Zhou B, Cao Y, Wu L, Yuan Y, Zeng Y. Cell attachment of periodontal ligament cells on commercially pure titanium at the early stage. J Huazhong Univ Sci Technolog Med Sci. 2004;24:307-8, 310 pubmed
    ..PDLCs showed different attaching phases and reached saturation in cell number at 2 h. It was concluded that PDLCs had good biocompatibility with cpTi, and showed a regular and dynamic pattern in the process of attaching to cpTi...
  81. Mahimkar R, Visaya O, Pollock A, Lovett D. The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins. Biochem J. 2005;385:461-8 pubmed
    ..It is concluded that ADAM9 is a polyvalent ligand, through its disintegrin domain, for multiple renal integrins of the beta1 class...
  82. Naba A, Reverdy C, Louvard D, Arpin M. Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. EMBO J. 2008;27:38-50 pubmed