erythroblasts

Summary

Summary: Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.

Top Publications

  1. Palis J. Ontogeny of erythropoiesis. Curr Opin Hematol. 2008;15:155-61 pubmed publisher
  2. Fraser S, Isern J, Baron M. Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression. Blood. 2007;109:343-52 pubmed
    Primitive erythroblasts (EryPs) are the first hematopoietic cell type to form during mammalian embryogenesis and emerge within the blood islands of the yolk sac...
  3. Satchwell T, Bell A, Pellegrin S, Kupzig S, Ridgwell K, Daniels G, et al. Critical band 3 multiprotein complex interactions establish early during human erythropoiesis. Blood. 2011;118:182-191 pubmed publisher
    ..These data are consistent with assembly of major components of the band 3 macrocomplex at an early stage during erythropoiesis. ..
  4. Menon M, Karur V, Bogacheva O, Bogachev O, Cuetara B, Wojchowski D. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest. 2006;116:683-94 pubmed
    ..As studied using a unique primary culture system, EpoR-HM erythroblasts exhibited marked stage-specific losses in Epo-dependent growth and survival...
  5. Ji P, Jayapal S, Lodish H. Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2. Nat Cell Biol. 2008;10:314-21 pubmed publisher
    ..of Rac GTPase during a late stage of erythropoiesis completely blocks enucleation of cultured mouse fetal erythroblasts without affecting their proliferation or differentiation...
  6. Sathyanarayana P, Dev A, Fang J, Houde E, Bogacheva O, Bogachev O, et al. EPO receptor circuits for primary erythroblast survival. Blood. 2008;111:5390-9 pubmed publisher
    ..survival genes has been investigated through transcriptome analyses of highly responsive, primary bone marrow erythroblasts. Two proapoptotic factors, Bim and FoxO3a, were rapidly repressed not only via the wild-type EPOR, but also by ..
  7. Migliaccio G, Sanchez M, Masiello F, Tirelli V, Varricchio L, Whitsett C, et al. Humanized culture medium for clinical expansion of human erythroblasts. Cell Transplant. 2010;19:453-69 pubmed publisher
    Ex vivo-generated erythroblasts represent alternative transfusion products...
  8. Koulnis M, Liu Y, Hallstrom K, Socolovsky M. Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response. PLoS ONE. 2011;6:e21192 pubmed publisher
    ..Here we identify a mechanism that helps to offset these effects. We recently showed that splenic early erythroblasts, 'EryA', negatively regulate their own survival by co-expressing the death receptor Fas, and its ligand, FasL...
  9. Ponthier J, Schluepen C, Chen W, Lersch R, Gee S, Hou V, et al. Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16. J Biol Chem. 2006;281:12468-74 pubmed
    ..hnRNP) A/B proteins to silencer elements in the exon and that down-regulation of hnRNP A/B proteins in erythroblasts leads to activation of E16 inclusion...

More Information

Publications81

  1. Sancilio S, Di Giacomo V, Quaglietta A, Iacone A, Angelucci D, Tatasciore U, et al. TRAIL promotes a pro-survival signal in erythropoietin-deprived human erythroblasts through the activation of an NF-kB/IkBalpha pathway. J Biol Regul Homeost Agents. 2011;25:375-86 pubmed
    The biological activity of TNF-related apoptosis inducing ligand (TRAIL) was analyzed in primary human erythroblasts derived from mononuclear cells of blood donors, kept in culture in the presence of 20 percent foetal calf serum, growth ..
  2. Coulon S, Dussiot M, Grapton D, Maciel T, Wang P, Callens C, et al. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia. Nat Med. 2011;17:1456-65 pubmed publisher
    ..The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood...
  3. Fujiwara T, Alqadi Y, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, et al. Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41:303-15.e1 pubmed publisher
    ..Next, we evaluated the role of ETO2 in human primary erythroblasts, derived from cord blood CD34-positive cells...
  4. Boissinot M, Cleyrat C, Vilaine M, Jacques Y, Corre I, Hermouet S. Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F. Oncogene. 2011;30:990-1001 pubmed publisher
    ..hepatocyte growth factor (HGF) and interleukin-11 (IL-11), BM mesenchymal stromal cells (BMMSCs) and erythroblasts being the main producers...
  5. Fabriek B, Polfliet M, Vloet R, van der Schors R, Ligtenberg A, Weaver L, et al. The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor. Blood. 2007;109:5223-9 pubmed
    Erythropoiesis occurs in erythroblastic islands, where developing erythroblasts closely interact with macrophages. The adhesion molecules that govern macrophage-erythroblast contact have only been partially defined...
  6. Chasis J, Mohandas N. Erythroblastic islands: niches for erythropoiesis. Blood. 2008;112:470-8 pubmed publisher
    ..These hematopoietic subcompartments are composed of erythroblasts surrounding a central macrophage...
  7. Wilber A, Tschulena U, Hargrove P, Kim Y, Persons D, Barbas C, et al. A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts. Blood. 2010;115:3033-41 pubmed publisher
    ..We used an in vitro culture model of human erythropoiesis in which late-stage erythroblasts are derived directly from human CD34(+) hematopoietic cells to evaluate HbF production...
  8. Keerthivasan G, Liu H, Gump J, Dowdy S, Wickrema A, Crispino J. A novel role for survivin in erythroblast enucleation. Haematologica. 2012;97:1471-9 pubmed publisher
    Nucleus free red blood cells are unique to mammals. During their terminal stage of differentiation, mammalian erythroblasts exit the cell cycle and enucleate...
  9. Rhodes M, Kopsombut P, Bondurant M, Price J, Koury M. Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythrocyte production by a different mechanism than erythropoietin. Blood. 2008;111:1700-8 pubmed
    b>Erythroblasts adhere to central macrophages forming erythroblastic islands in hematopoietic tissues, but the function of these islands is not understood...
  10. Lee G, Lo A, Short S, Mankelow T, Spring F, Parsons S, et al. Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Blood. 2006;108:2064-71 pubmed
    Erythroid progenitors differentiate in erythroblastic islands, bone marrow niches composed of erythroblasts surrounding a central macrophage...
  11. Ribeil J, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, Dussiot M, et al. Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature. 2007;445:102-5 pubmed
    ..These effects are abrogated by the transduction of a caspase-resistant GATA-1 mutant. Thus, in erythroid precursors undergoing terminal differentiation, Hsp70 prevents active caspase-3 from cleaving GATA-1 and inducing apoptosis. ..
  12. Salomao M, Chen K, Villalobos J, Mohandas N, An X, Chasis J. Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation. Blood. 2010;116:267-9 pubmed publisher
    ..We conclude that aberrant protein sorting is one mechanistic basis for protein deficiencies in HE and HS...
  13. Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells. Nat Biotechnol. 2006;24:1255-6 pubmed
    ..Our method may represent an efficient way to produce transfusable RBCs on a large scale from hematopoietic progenitors...
  14. Fang J, Menon M, Zhang D, Torbett B, Oxburgh L, Tschan M, et al. Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2. Blood. 2008;112:886-90 pubmed publisher
    ..Toward identifying novel regulators of this process, murine splenic erythroblasts at 3 developmental stages were prepared, purified and profiled...
  15. Asano H, Fukunaga S, Deguchi Y, Kawamura S, Inaba M. Bcl-xL and Mcl-1 are involved in prevention of in vitro apoptosis in rat late-stage erythroblasts derived from bone marrow. J Toxicol Sci. 2012;37:23-31 pubmed
    ..However, little has been reported on the role of the anti-apoptotic Bcl-2 family members in rat late-stage erythroblasts that are no longer erythropoietin (EPO)-dependent...
  16. Sankaran V, Orkin S, Walkley C. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev. 2008;22:463-75 pubmed publisher
    ..absence causes ineffective erythropoiesis, with a differentiation block at the transition from early to late erythroblasts. Unexpectedly, in addition to a failure to properly exit the cell cycle, mitochondrial biogenesis fails to be ..
  17. Betin V, Singleton B, Parsons S, Anstee D, Lane J. Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation. Autophagy. 2013;9:881-93 pubmed publisher
    ..of the lysosomal compartment, suggesting that the actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts.
  18. Tamez P, Liu H, Wickrema A, Haldar K. P. falciparum modulates erythroblast cell gene expression in signaling and erythrocyte production pathways. PLoS ONE. 2011;6:e19307 pubmed publisher
    ..Further P. falciparum may modulate gene expression in bystander erythroblasts and thus influence pathways of erythrocyte development...
  19. Dev A, Fang J, Sathyanarayana P, Pradeep A, Emerson C, Wojchowski D. During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool. Blood. 2010;116:5334-46 pubmed publisher
    ..Overall, findings reveal a novel transitional proerythroblast compartment that deploys unique expansion devices...
  20. England S, McGrath K, Frame J, Palis J. Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood. 2011;117:2708-17 pubmed publisher
    ..Extensively self-renewing erythroblasts, despite their near complete maturity within the hematopoietic hierarchy, may ultimately serve as a renewable ..
  21. Ioudinkova E, Ulianov S, Bunina D, Iarovaia O, Gavrilov A, Razin S. The inactivation of the ? gene in chicken erythroblasts of adult lineage is not mediated by packaging of the embryonic part of the ?-globin gene domain into a repressive heterochromatin-like structure. Epigenetics. 2011;6:1481-8 pubmed publisher
    ..This conclusion is supported by the demonstration that in chicken erythroblasts of adult lineage, the embryonal and adult segments of the ?-globin gene domain show similar elevated ..
  22. Qian E, Ge D, Kong S. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol. 2011;133:308-14 pubmed publisher
    ..Rhodiola rosea is commonly used in China and Tibet folk medicine for the treatment of high altitude sickness, anoxia and mountain malhypoxia...
  23. Takamura S, Tsuji Kawahara S, Yagita H, Akiba H, Sakamoto M, Chikaishi T, et al. Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors. J Immunol. 2010;184:4696-707 pubmed publisher
    ..Acute FV-induced disease is characterized by a rapid increase in the number of virus-infected erythroblasts, leading to massive splenomegaly...
  24. Fujiwara T, Harigae H, Okitsu Y, Takahashi S, Yokoyama H, Yamada M, et al. Expression analyses and transcriptional regulation of mouse nucleolar spindle-associated protein gene in erythroid cells: essential role of NF-Y. Br J Haematol. 2006;135:583-90 pubmed
    ..In fractionated murine erythroblasts, NuSAP mRNA was remarkably more abundant in the subset corresponding to immature erythroblasts (TER119(+)CD71(..
  25. Liu J, Zhang J, Ginzburg Y, Li H, Xue F, De Franceschi L, et al. Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis. Blood. 2013;121:e43-9 pubmed publisher
    ..undergoes 3 mitosis to generate sequentially 2 basophilic, 4 polychromatic, and 8 orthochromatic erythroblasts, currently there is no method to quantitatively monitor this highly regulated process...
  26. Prus E, Fibach E. The labile iron pool in human erythroid cells. Br J Haematol. 2008;142:301-7 pubmed publisher
    ..The methodology presented might be useful for evaluating the LIP in various diseases and for studying the efficacy of iron-chelators...
  27. Liu Y, Pop R, Sadegh C, Brugnara C, Haase V, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006;108:123-33 pubmed
    ..In the mouse spleen, an erythropoietic reserve organ, early erythroblasts were present at lower frequencies and were undergoing higher rates of apoptosis than equivalent cells in bone ..
  28. Wang J, Ramirez T, Ji P, Jayapal S, Lodish H, Murata Hori M. Mammalian erythroblast enucleation requires PI3K-dependent cell polarization. J Cell Sci. 2012;125:340-9 pubmed publisher
    ..We propose that enucleation is regulated by microtubules and PI3K signaling in a manner mechanistically similar to directed cell locomotion...
  29. Wolk M, Martin J, Reinus C. Development of fetal haemoglobin-blood cells (F cells) within colorectal tumour tissues. J Clin Pathol. 2006;59:598-602 pubmed
    ..An immunohistochemical study was carried out on some of the most common kinds of cancer. All of these cancers had serologically high levels of HbF as evaluated previously...
  30. Williams K, Szilagyi A, Conrad P, Halerz M, Kini A, Li Y, et al. Peripheral blood mononuclear cell-derived erythroid progenitors and erythroblasts are decreased in burn patients. J Burn Care Res. 2013;34:133-41 pubmed publisher
    ..CD36) and erythroblast subpopulations (colony-forming unit erythroids, Proerythroblasts, and intermediate erythroblasts) were identified based on the expressions of CD71 and CD235a by flow cytometry, calculated per million ..
  31. Hristoskova S, Holzgreve W, Hahn S, Rusterholz C. Human mature erythroblasts are resistant to apoptosis. Exp Cell Res. 2007;313:1024-32 pubmed
    ..We show here that, by contrast, mature erythroblasts are resistant to apoptosis...
  32. Macaulay I, Tijssen M, Thijssen Timmer D, Gusnanto A, Steward M, Burns P, et al. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood. 2007;109:3260-9 pubmed
    ..unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs)...
  33. Zhang D, Senecal T, Ghosh M, Ollivierre Wilson H, Tu T, Rouault T. Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood. 2011;118:2868-77 pubmed publisher
    ..We previously demonstrated that FPN1 was highly expressed in erythroblasts, a cell type that consumes most of the serum iron for use in hemoglobin synthesis...
  34. Griffiths R, Heesom K, Anstee D. Normal prion protein trafficking in cultured human erythroblasts. Blood. 2007;110:4518-25 pubmed
    ..to another glycosylphosphoinositol-anchored protein CD59, PrP(c) at the cell surface of cultured human erythroblasts is rapidly internalized through the endosomal pathway, where it colocalizes with the tetraspanin CD63...
  35. Mohandas N, Chasis J. The erythroid niche: molecular processes occurring within erythroblastic islands. Transfus Clin Biol. 2010;17:110-1 pubmed publisher
    b>Erythroblasts terminally differentiate within specialized niches composed of erythroblast islands nesting in extracellular matrix proteins. A number of adhesion molecules active in erythroid island attachments have been identified...
  36. Ye H, Jeong S, Ghosh M, Kovtunovych G, Silvestri L, Ortillo D, et al. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. J Clin Invest. 2010;120:1749-61 pubmed publisher
    ..b>Erythroblasts express both IRP-repressible ALAS2 and non-IRP-repressible ferroportin 1b...
  37. Ubukawa K, Guo Y, Takahashi M, Hirokawa M, Michishita Y, Nara M, et al. Enucleation of human erythroblasts involves non-muscle myosin IIB. Blood. 2012;119:1036-44 pubmed publisher
    Mammalian erythroblasts undergo enucleation, a process thought to be similar to cytokinesis...
  38. Karur V, Lowell C, Besmer P, Agosti V, Wojchowski D. Lyn kinase promotes erythroblast expansion and late-stage development. Blood. 2006;108:1524-32 pubmed
    ..Furthermore, ex vivo analyses of the development of bone marrow-derived Lyn-/- erythroblasts in unique primary culture systems indicated positive roles for Lyn at 2 stages...
  39. Hu J, Liu J, Xue F, Halverson G, Reid M, Guo A, et al. Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo. Blood. 2013;121:3246-53 pubmed publisher
    ..Use of band 3 and ?4 integrin enabled us to isolate erythroblasts at specific developmental stages from primary human bone marrow...
  40. Popova E, Krauss S, Short S, Lee G, Villalobos J, Etzell J, et al. Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. Chromosome Res. 2009;17:47-64 pubmed publisher
    ..molecular basis for mammalian erythroblast chromatin condensation, we used Friend virus-infected murine spleen erythroblasts that undergo terminal differentiation in vitro...
  41. Ripich T, Jessberger R. SWAP-70 regulates erythropoiesis by controlling ?4 integrin. Haematologica. 2011;96:1743-52 pubmed publisher
    ..Integrin-dependent adhesion plays important roles in erythropoiesis, but how integrins are regulated during erythropoiesis remains largely unknown...
  42. Zhong X, Steinborn A, Sohn C, Holzgreve W, Hahn S. High levels of circulatory erythroblasts and cell-free DNA prior to intrauterine fetal death. Prenat Diagn. 2006;26:1272-3 pubmed
  43. Chen K, Liu J, Heck S, Chasis J, An X, Mohandas N. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc Natl Acad Sci U S A. 2009;106:17413-8 pubmed publisher
    ..to reticulocyte; this enabled us to devise a new strategy for distinguishing unambiguously between erythroblasts at successive developmental stages...
  44. Shearstone J, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M. Global DNA demethylation during mouse erythropoiesis in vivo. Science. 2011;334:799-802 pubmed publisher
    ..We studied DNA methylation in differentiating mouse erythroblasts in vivo by using genomic-scale reduced representation bisulfite sequencing (RRBS)...
  45. Fang J, Menon M, Kapelle W, Bogacheva O, Bogachev O, Houde E, et al. EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts. Blood. 2007;110:2361-70 pubmed
    Erythropoietin (EPO's) actions on erythroblasts are ascribed largely to survival effects. Certain studies, however, point to EPO-regulated proliferation...
  46. van den Akker E, Satchwell T, Pellegrin S, Flatt J, Maigre M, Daniels G, et al. Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (-) cells (mutations Chartres 1 and 2). Haematologica. 2010;95:1278-86 pubmed publisher
    ..We decided to investigate at which stage of erythropoiesis these hallmarks of protein 4.2 deficiency arise in a novel protein 4.2 patient and whether they cause disruption to the band 3 macrocomplex...
  47. Tamez P, Liu H, Fernandez Pol S, Haldar K, Wickrema A. Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection. Blood. 2009;114:3652-5 pubmed publisher
    ..Together these data suggest that the potential for complexity of host interactions involved in infection may be vastly greater than hitherto realized...
  48. Yamamoto M, Clark T, Gee S, Kang J, Schweitzer A, Wickrema A, et al. Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis. Blood. 2009;113:3363-70 pubmed publisher
    ..proteins (SNRP70, HNRPLL, MBNL2) may indicate significant changes in the RNA processing machinery of late erythroblasts. Together, these results support the existence of a regulated alternative pre-mRNA splicing program that is ..
  49. Gavrilov A, Razin S. Spatial configuration of the chicken alpha-globin gene domain: immature and active chromatin hubs. Nucleic Acids Res. 2008;36:4629-40 pubmed publisher
    ..In differentiated cultured erythroblasts and in 10-day chick embryo erythrocytes expressing 'adult' alpha(A) and alpha(D) globin genes the following ..
  50. Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, et al. Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13). Int J Hematol. 2011;93:311-318 pubmed publisher
    ..These findings suggest that loss of the ABCB7 gene may be a pathogenetic factor underlying mitochondrial iron accumulation in RARS patients with idicXq13. ..
  51. Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed
    ..mfrn is highly expressed in fetal and adult haematopoietic tissues of zebrafish and mouse. Erythroblasts generated from murine embryonic stem cells null for Mfrn (also known as Slc25a37) show maturation arrest with ..
  52. Wojchowski D, Sathyanarayana P, Dev A. Erythropoietin receptor response circuits. Curr Opin Hematol. 2010;17:169-76 pubmed publisher
  53. Ji P, Yeh V, Ramirez T, Murata Hori M, Lodish H. Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Haematologica. 2010;95:2013-21 pubmed publisher
    ..homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation.
  54. Chasis J. Erythroblastic islands: specialized microenvironmental niches for erythropoiesis. Curr Opin Hematol. 2006;13:137-41 pubmed
    ..This review focuses on current understanding of molecular mechanisms operating within erythroblastic islands including cell-cell adhesion, regulatory feedback, and central macrophage function...
  55. Soni S, Bala S, Gwynn B, Sahr K, Peters L, Hanspal M. Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion. J Biol Chem. 2006;281:20181-9 pubmed
    ..the erythroblastic island, a multicellular structure composed of a central macrophage surrounded by developing erythroblasts. Erythroblast-macrophage interactions play a central role in the terminal maturation of erythroblasts, ..
  56. Rimmelé P, Kosmider O, Mayeux P, Moreau Gachelin F, Guillouf C. Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation. Blood. 2007;109:3007-14 pubmed
    ..These findings reveal 2 distinct roles for Spi-1 during erythroleukemogenesis: Spi-1 blocks the erythroid differentiation program and acts to impair apoptotic death in cooperation with an Epo signaling...
  57. Diwan A, Koesters A, Odley A, Pushkaran S, Baines C, Spike B, et al. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A. 2007;104:6794-9 pubmed
    ..The critical proapoptotic pathways inhibited by Bcl-xl in erythroblasts are unknown...
  58. Dirlam A, Spike B, Macleod K. Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007;27:8713-28 pubmed
    ..persistent defects in placental development, indicating that deregulated E2f-2 activity in differentiating erythroblasts contributes to the premature lethality of Rb null mice...
  59. Ru Y, Mao B, Zhang F, Pang T, Zhao S, Liu J, et al. Invasion of erythroblasts by Pasmodium vivax: A new mechanism contributing to malarial anemia. Ultrastruct Pathol. 2009;33:236-42 pubmed publisher
    ..vivax malaria show a hitherto undescribed mechanism contributing to malarial anemia, namely, infection of erythroblasts by parasites and their subsequent degradation...
  60. Lodish H, Flygare J, Chou S. From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones. IUBMB Life. 2010;62:492-6 pubmed publisher
  61. Frisan E, Vandekerckhove J, de Thonel A, Pierre Eugène C, Sternberg A, Arlet J, et al. Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes. Blood. 2012;119:1532-42 pubmed publisher
    ..Analysis of gene expression in MDS erythroblasts obtained by ex vivo cultures demonstrates the down-regulation of a set of GATA-1 transcriptional target genes, ..
  62. van den Akker E, Satchwell T, Pellegrin S, Daniels G, Toye A. The majority of the in vitro erythroid expansion potential resides in CD34(-) cells, outweighing the contribution of CD34(+) cells and significantly increasing the erythroblast yield from peripheral blood samples. Haematologica. 2010;95:1594-8 pubmed publisher
    ..disease requires a robust culture system that consistently and reliably generates large numbers of immature erythroblasts that can be induced to differentiate synchronously...
  63. Kang Y, Sanalkumar R, O Geen H, Linnemann A, Chang C, Bouhassira E, et al. Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol. 2012;32:226-39 pubmed publisher
    ..These results illustrate a novel mechanism by which a master regulator of development establishes a genetic network to instigate cell-type-specific autophagy...
  64. Pellegrin S, Heesom K, Satchwell T, Hawley B, Daniels G, van den Akker E, et al. Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal. PLoS ONE. 2012;7:e38356 pubmed publisher
    ..Here we study the effects of Epo removal on primary human erythroblasts grown from peripheral blood CD34(+) cells...
  65. Lewis J, Hori T, Rise M, Walsh P, Currie S. Transcriptome responses to heat stress in the nucleated red blood cells of the rainbow trout (Oncorhynchus mykiss). Physiol Genomics. 2010;42:361-73 pubmed publisher
    ..Moreover, salmonid transcripts that are consistently dysregulated in blood in response to heat stress are potential candidates of nonlethal biomarkers of exposure to this particular stressor...
  66. Keerthivasan G, Small S, Liu H, Wickrema A, Crispino J. Vesicle trafficking plays a novel role in erythroblast enucleation. Blood. 2010;116:3331-40 pubmed publisher
    Enucleation of mammalian erythroblasts is a process whose mechanism is largely undefined. The prevailing model suggests that nuclear extrusion occurs via asymmetric cytokinesis...
  67. Lee Y, de Vasconcellos J, Yuan J, Byrnes C, Noh S, Meier E, et al. LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. Blood. 2013;122:1034-41 pubmed publisher
    ..LIN28B in human erythroid cell development, lentiviral transduction was used to knockdown LIN28B expression in erythroblasts cultured from human umbilical cord CD34+ cells...
  68. Nikpour M, Pellagatti A, Liu A, Karimi M, Malcovati L, Gogvadze V, et al. Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF. Br J Haematol. 2010;149:844-54 pubmed publisher
    ..To dissect the molecular mechanisms underlying the RARS phenotype and anti-apoptotic effects of G-CSF, erythroblasts generated from normal (NBM) and RARS marrow CD34(+) cells were cultured +/-G-CSF and subjected to gene ..
  69. White T, Bushdid P, Ritter S, Laffan S, Clark R. Artesunate-induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo. Birth Defects Res B Dev Reprod Toxicol. 2006;77:413-29 pubmed
    ..Birth Defects Res B 71:380-394, 2004; White et al.: Birth Defects Res A 70:265, 2004)...
  70. Renella R, Roberts N, Brown J, De Gobbi M, Bird L, Hassanali T, et al. Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts. Blood. 2011;117:6928-38 pubmed publisher
    ..anemia type 1 (CDA-1), a rare inborn anemia characterized by abnormal chromatin ultrastructure in erythroblasts, is caused by abnormalities in codanin-1, a highly conserved protein of unknown function...
  71. Chung B, Verdier F, Matak P, Deschemin J, Mayeux P, Vaulont S. Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone. FASEB J. 2010;24:2093-103 pubmed publisher
    ..To identify new factors secreted by the erythroblasts that could influence hepcidin synthesis, we set up a coculture model...
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