erythroid precursor cells


Summary: The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.

Top Publications

  1. Udomsakdi C, Eaves C, Sutherland H, Lansdorp P. Separation of functionally distinct subpopulations of primitive human hematopoietic cells using rhodamine-123. Exp Hematol. 1991;19:338-42 pubmed
  2. Koury M, Bondurant M. Control of red cell production: the roles of programmed cell death (apoptosis) and erythropoietin. Transfusion. 1990;30:673-4 pubmed
  3. Carruthers A, Naftalin R. Altered GLUT1 substrate selectivity in human erythropoiesis?. Cell. 2009;137:200-1; author reply 201-2 pubmed publisher
  4. Janovitz T, Wong S, Young N, Oliveira T, Falck Pedersen E. Parvovirus B19 integration into human CD36+ erythroid progenitor cells. Virology. 2017;511:40-48 pubmed publisher
    ..We present the first direct evidence that B19V infection of erythroid progenitor cells disrupts the human genome and facilitates viral DNA integration. ..
  5. Philpott C, Ryu M, Frey A, Patel S. Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells. J Biol Chem. 2017;292:12764-12771 pubmed publisher
    ..The monothiol glutaredoxin Glrx3 and BolA2 function as a [2Fe-2S] chaperone complex. These proteins form a core system of cytosolic iron cofactor chaperones in mammalian cells. ..
  6. Knutson M. Iron transport proteins: Gateways of cellular and systemic iron homeostasis. J Biol Chem. 2017;292:12735-12743 pubmed publisher
    ..This review provides an overview of how these cell types handle iron, highlighting how iron and heme transporters mediate the exchange and distribution of body iron in health and disease. ..
  7. Steinkellner H, Singh H, Muckenthaler M, Goldenberg H, Moganty R, Scheiber Mojdehkar B, et al. No changes in heme synthesis in human Friedreich┬┤s ataxia erythroid progenitor cells. Gene. 2017;621:5-11 pubmed publisher
    ..Our data strongly support the fact that so far no anemia in FRDA patients was reported. ..
  8. Haylock D, To L, Dowse T, Juttner C, Simmons P. Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage. Blood. 1992;80:1405-12 pubmed
    ..This stroma-free, cytokine-driven culture system can achieve a degree of amplification, which suggests the feasibility of ex vivo culture of hematopoietic progenitor cells as an adjunct to hematopoietic stem cell transplantation. ..
  9. Masaki S, Ohtsuka R, Abe Y, Umemura T. [Expression analysis of microRNAs in erythropoiesis]. Rinsho Byori. 2008;56:1086-92 pubmed
    ..These observations suggest that an analysis of microRNAs is a new relevant approach to understand underlying mechanisms of hematological disorders. ..

More Information


  1. Wickrema A, Krantz S, Winkelmann J, Bondurant M. Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells. Blood. 1992;80:1940-9 pubmed
    ..The human cell system described here is well suited for the study of a wide variety of biochemical events during late erythroid differentiation. ..
  2. Mohan K, Stevenson M. Dyserythropoiesis and severe anaemia associated with malaria correlate with deficient interleukin-12 production. Br J Haematol. 1998;103:942-9 pubmed
    ..Taken together, these findings suggest that defective IL-12 production in A/J mice during the early course of infection may result in fatal anaemia. ..
  3. Jacobs Helber S, Wickrema A, Birrer M, Sawyer S. AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells. Mol Cell Biol. 1998;18:3699-707 pubmed
  4. Starnes L, Sorrentino A, Ferracin M, Negrini M, Pelosi E, Nervi C, et al. A transcriptome-wide approach reveals the key contribution of NFI-A in promoting erythroid differentiation of human CD34(+) progenitors and CML cells. Leukemia. 2010;24:1220-3 pubmed publisher
  5. Kiladjian J, Masse A, Cassinat B, Mokrani H, Teyssandier I, Le Couedic J, et al. Clonal analysis of erythroid progenitors suggests that pegylated interferon alpha-2a treatment targets JAK2V617F clones without affecting TET2 mutant cells. Leukemia. 2010;24:1519-23 pubmed publisher
  6. Labie D. [BCL11A controls the expression of the human fetal hemoglobin]. Med Sci (Paris). 2012;28:923-5 pubmed publisher
  7. Briddell R, Kern B, Zilm K, Stoney G, McNiece I. Purification of CD34+ cells is essential for optimal ex vivo expansion of umbilical cord blood cells. J Hematother. 1997;6:145-50 pubmed
    ..These data demonstrate that CD34+ cell selection is necessary for optimal expansion of both GM-CFC and BFU-E cells. The cell numbers thus obtained postexpansion may be sufficient for transplantation in adults. ..
  8. Bondy C, Chin E, Smith B, Preston G, Agre P. Developmental gene expression and tissue distribution of the CHIP28 water-channel protein. Proc Natl Acad Sci U S A. 1993;90:4500-4 pubmed
    ..The studies also suggest other possible functions during fetal development and predict that complex mechanisms will be needed for regulation of CHIP28 gene expression in diverse tissues at distinct points in development. ..
  9. Yap G, Stevenson M. Plasmodium chabaudi AS: erythropoietic responses during infection in resistant and susceptible mice. Exp Parasitol. 1992;75:340-52 pubmed
  10. Alamo I, Kannan K, Loftus T, Ramos H, Efron P, Mohr A. Severe trauma and chronic stress activates extramedullary erythropoiesis. J Trauma Acute Care Surg. 2017;83:144-150 pubmed publisher
    ..Splenic EPOr expression was significantly decreased after LCHS/CS. Extramedullary erythropoiesis may play a key role in identifying new therapies to aid the recovery from acute anemia after severe trauma and chronic stress. ..
  11. Ganaie S, Zou W, Xu P, Deng X, Kleiboeker S, Qiu J. Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex. PLoS Pathog. 2017;13:e1006370 pubmed publisher
    ..Our results demonstrated that pimozide could be a promising antiviral drug for treatment of B19V-related diseases. ..
  12. Dai Y, Chen T, Ijaz H, Cho E, Steinberg M. SIRT1 activates the expression of fetal hemoglobin genes. Am J Hematol. 2017;92:1177-1186 pubmed publisher
    ..SIRT1 is a potential therapeutic target for ?-globin gene induction, and small molecule SIRT1 activators might serve as a lead compound for the development of new HbF inducers. ..