myeloid progenitor cells

Summary

Summary: Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.

Top Publications

  1. Fogg D, Sibon C, Miled C, Jung S, Aucouturier P, Littman D, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science. 2006;311:83-7 pubmed
    ..Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS...
  2. Wang D, D Costa J, Civin C, Friedman A. C/EBPalpha directs monocytic commitment of primary myeloid progenitors. Blood. 2006;108:1223-9 pubmed
    ..A C/EBPalpha variant incapable of zippering with c-Jun did not induce monopoiesis, and a variant unable to bind NF-kappaB p50 stimulated granulopoiesis, suggesting their cooperation with C/EBPalpha during monocytic commitment...
  3. Cheung A, Abendroth A, Cunningham A, Slobedman B. Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells. Blood. 2006;108:3691-9 pubmed
    ..associated with the establishment of latency, we tracked the virus following infection of primary human myeloid progenitor cells at days 1, 2, 3, 5, and 11...
  4. Delano M, Scumpia P, Weinstein J, Coco D, Nagaraj S, Kelly Scumpia K, et al. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med. 2007;204:1463-74 pubmed
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  5. Kuehner S, Schlaier M, Schwarz K, Speit G. Analysis of leukemia-specific aneuploidies in cultured myeloid progenitor cells in the absence and presence of formaldehyde exposure. Toxicol Sci. 2012;128:72-8 pubmed publisher
    ..FA) at the workplace might induce leukemia-specific aneuploidies (monosomy 7 and trisomy 8) in cultured myeloid progenitor cells. Despite its preliminary character, this study was considered by the International Agency for Research on ..
  6. Huang W, Bei L, Eklund E. Fas-associated phosphatase 1 (Fap1) influences ?catenin activity in myeloid progenitor cells expressing the Bcr-abl oncogene. J Biol Chem. 2013;288:12766-76 pubmed publisher
    ..We found previously that expression of the CML-related Bcr-abl oncoprotein in myeloid progenitor cells increases expression of Fas-associated phosphatase 1 (Fap1)...
  7. Jude C, Climer L, Xu D, Artinger E, Fisher J, Ernst P. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007;1:324-37 pubmed publisher
    ..These studies demonstrate that Mll plays selective and independent roles within the hematopoietic system, maintaining quiescence in HSCs and promoting proliferation in progenitors...
  8. Kusmartsev S, Nagaraj S, Gabrilovich D. Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. J Immunol. 2005;175:4583-92 pubmed
    ..Thus, this is a first demonstration that in tumor-bearing mice CD8+ T cell tolerance is induced primarily by ImC that may have direct implications for cancer immunotherapy...
  9. Shah C, Bei L, Wang H, Platanias L, Eklund E. The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells. J Biol Chem. 2013;288:32490-505 pubmed publisher
    ..Fgf2 influences proliferation and survival of hematopoietic stem cells and myeloid progenitor cells, and increased Fgf2-expression has been described in AMLs...

More Information

Publications76

  1. Sollars V, Pequignot E, Rothstein J, Buchberg A. Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes. Mamm Genome. 2006;17:808-21 pubmed
    ..Given the importance of this cell compartment in leukemia progression and the soon to be released genomic sequence of 15 mouse strains, these differences may provide a valuable tool for research into leukemia...
  2. Oakley K, Han Y, Vishwakarma B, Chu S, Bhatia R, Gudmundsson K, et al. Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. Blood. 2012;119:6099-108 pubmed publisher
    ..Thus, Setbp1 activation represents a novel mechanism conferring self-renewal capability to myeloid progenitors in myeloid leukemia development...
  3. Gao D, Joshi N, Choi H, Ryu S, Hahn M, Catena R, et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res. 2012;72:1384-94 pubmed publisher
    ..models of spontaneous breast cancer, we show enhanced recruitment of bone marrow-derived CD11b(+)Gr1(+) myeloid progenitor cells in the premetastatic lungs...
  4. Farias I, do Carmo Araújo M, Zimmermann E, Dalmora S, Benedetti A, Alvarez Silva M, et al. Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells. J Ethnopharmacol. 2011;137:856-63 pubmed publisher
  5. Kawamoto H, Ikawa T, Masuda K, Wada H, Katsura Y. A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model. Immunol Rev. 2010;238:23-36 pubmed publisher
    ..The validity of the myeloid-based model of hematopoiesis will be discussed in reference to these two issues, developmental potential and cell fate...
  6. Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330:841-5 pubmed publisher
    ..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders...
  7. Pan J, Zou J, Wu D, Roberson R, Hennings L, Ma X, et al. TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. Mol Cancer Res. 2008;6:862-72 pubmed publisher
    ..Here, we show that retroviral transduction of TLS-ERG confers a growth advantage to L-G myeloid progenitor cells and blocks terminal differentiation...
  8. Liu K, Victora G, Schwickert T, Guermonprez P, Meredith M, Yao K, et al. In vivo analysis of dendritic cell development and homeostasis. Science. 2009;324:392-7 pubmed publisher
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  9. Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, Iwama A. Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. Leukemia. 2011;25:1335-43 pubmed publisher
  10. Geissmann F, Manz M, Jung S, Sieweke M, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327:656-61 pubmed publisher
    ..Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated...
  11. Belyaev N, Brown D, Diaz A, Rae A, Jarra W, Thompson J, et al. Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria. Nat Immunol. 2010;11:477-85 pubmed publisher
    ..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
  12. Dauffy J, Mouchiroud G, Bourette R. The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells. J Leukoc Biol. 2006;79:173-83 pubmed
    ..Moreover, this study suggests that other members of the Ifi family might act as regulators of hematopoiesis under the control of hemopoietic cytokines...
  13. Zhang L, Tang X, Rothman N, Vermeulen R, Ji Z, Shen M, et al. Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev. 2010;19:80-8 pubmed publisher
    ..Further, myeloid progenitor cells, the target for leukemogenesis, were cultured from the workers to quantify the level of leukemia-specific ..
  14. Jabbour A, Daunt C, Green B, Vogel S, Gordon L, Lee R, et al. Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood. 2010;115:344-52 pubmed publisher
    ..Thus, we conclude that p53 protein is activated after IL-3 deprivation by loss of MDM2. Activated p53 transcriptionally up-regulates Puma, which initiates apoptosis...
  15. Nagai Y, Garrett K, Ohta S, Bahrun U, Kouro T, Akira S, et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity. 2006;24:801-12 pubmed
    ..Thus, the preferential pathogen-mediated stimulation of myeloid differentiation pathways may provide a means for rapid replenishment of the innate immune system during infection...
  16. Bruns I, Czibere A, Fischer J, Roels F, Cadeddu R, Buest S, et al. The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence. Leukemia. 2009;23:892-9 pubmed publisher
    ..Based on our findings we propose a loss of quiescence of the CML HSC on detachment from the niche leading to expansion of myeloid progenitors...
  17. Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, et al. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev. 2006;20:3010-21 pubmed
    ..We propose that the order of expression of key transcription factors is critical for their interplay to selectively drive lineage specification programs, by which stem cells could generate multiple lineage cells in a hierarchical manner...
  18. Anderson K, Rusterholz C, Mansson R, Jensen C, Bacos K, Zandi S, et al. Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes. Blood. 2007;109:3697-705 pubmed
    ..Along with the established ectopic expression of PAX5 in acute myeloid leukemia, this motivates a careful investigation of the potential involvement of ectopic PAX5 expression in myeloid and biphenotypic leukemias...
  19. Sharma Y, Astle C, Harrison D. Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol. 2007;35:214-220 pubmed
    ..This study tests how each mutation affects HSC function...
  20. Pronk C, Rossi D, Mansson R, Attema J, Norddahl G, Chan C, et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell. 2007;1:428-42 pubmed publisher
  21. Adolfsson J, Borge O, Bryder D, Theilgaard Monch K, Astrand Grundström I, Sitnicka E, et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001;15:659-69 pubmed
    ..Thus, upregulation of flt3 expression on Lin(-)Sca1(+)c-kit(+) HSC cells is accompanied by loss of self-renewal capacity but sustained lymphoid-restricted reconstitution potential...
  22. Koritschoner N, Madruga J, Knespel S, Blendinger G, Anzinger B, Otto A, et al. The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells. Cell Growth Differ. 2001;12:563-72 pubmed
    ..TR4, when ectopically expressed in bone marrow cells via retrovirus vector, promotes proliferation of myeloid progenitor cells. Cells represent promyelocytes as judged by morphological features, expression of cell surface molecules, ..
  23. Bronte V, Apolloni E, Cabrelle A, Ronca R, Serafini P, Zamboni P, et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood. 2000;96:3838-46 pubmed
    ..Blood. 2000;96:3838-3846)..
  24. Traver D, Miyamoto T, Christensen J, Iwasaki Arai J, Akashi K, Weissman I. Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Blood. 2001;98:627-35 pubmed
    ..Blood. 2001;98:627-635)..
  25. Hermans M, van de Geijn G, Antonissen C, Gits J, van Leeuwen D, Ward A, et al. Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells. Blood. 2003;101:2584-90 pubmed
    ..These findings suggest that tyrosines in the cytoplasmic domain of G-CSF-R, although dispensable for G-CSF-induced colony growth, recruit signaling mechanisms that regulate the maintenance and outgrowth of myeloid progenitor cells.
  26. Keeshan K, Santilli G, Corradini F, Perrotti D, Calabretta B. Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation. Blood. 2003;102:1267-75 pubmed
  27. Iwasaki H, Mizuno S, Wells R, Cantor A, Watanabe S, Akashi K. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity. 2003;19:451-62 pubmed
    ..Thus, GATA-1 specifically instructs MegE commitment while excluding other fate outcomes in stem and progenitor cells, suggesting that regulation of GATA-1 is critical in maintaining multilineage homeostasis...
  28. Shahbazian L, Quinton L, Bagby G, Nelson S, Wang G, Zhang P. Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation. Crit Care Med. 2004;32:1740-6 pubmed
    ..The process by which hematopoietic tissues respond to a pulmonary infection remains poorly understood. This study investigated the potential role of lung-derived granulopoietic cytokines in facilitating this response...
  29. Eberlin S, dos Santos L, Queiroz M. Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes. Int Immunopharmacol. 2005;5:1235-46 pubmed
  30. Noda S, Aguirre S, BitMansour A, Brown J, Sparer T, Huang J, et al. Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination. Blood. 2006;107:30-8 pubmed
    ..Mobilization influences levels of virus dissemination via the bloodstream to salivary glands and is dependent on a myelomonocytic cell type other than mature macrophages...
  31. Marteijn J, van Emst L, Erpelinck Verschueren C, Nikoloski G, Menke A, de Witte T, et al. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. Blood. 2005;106:4114-23 pubmed
    ..We conclude that proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells.
  32. Zinkel S, Hurov K, Ong C, Abtahi F, Gross A, Korsmeyer S. A role for proapoptotic BID in the DNA-damage response. Cell. 2005;122:579-91 pubmed
    ..We further demonstrate that this role is mediated through BID phosphorylation by the DNA-damage kinase ATM. These results establish a link between proapoptotic Bid and the DNA-damage response...
  33. Lee S, Zhou G, Clark T, Chen J, Rowley J, Wang S. The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc Natl Acad Sci U S A. 2001;98:3340-5 pubmed
    We performed a genome-wide analysis of gene expression in primary human CD15(+) myeloid progenitor cells. By using the serial analysis of gene expression (SAGE) technique, we obtained quantitative information for the expression of 37,519 ..
  34. Cozzio A, Passegue E, Ayton P, Karsunky H, Cleary M, Weissman I. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17:3029-35 pubmed
  35. Cario G, Skokowa J, Wang Z, Bucan V, Zeidler C, Stanulla M, et al. Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor. Br J Haematol. 2005;129:275-8 pubmed
    Apoptosis is accelerated in the myeloid progenitor cells of patients with severe congenital neutropenia (CN). Granulocyte colony-stimulating factor (G-CSF) increases neutrophil numbers in most CN patients...
  36. Adolfsson J, Mansson R, Buza Vidas N, Hultquist A, Liuba K, Jensen C, et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell. 2005;121:295-306 pubmed
    ..Based on these observations, we propose a revised road map for adult blood lineage development...
  37. Papadaki H, Eliopoulos A, Kosteas T, Gemetzi C, Damianaki A, Koutala H, et al. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood. 2003;101:2591-600 pubmed
    ..necrosis factor alpha and cytokine levels in culture supernatants inversely correlated with the number of myeloid progenitor cells and positively with the proportion of apoptotic CD34(+) cells...
  38. Reddy V, Iwama A, Iotzova G, Schulz M, Elsasser A, Vangala R, et al. Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood. 2002;100:483-90 pubmed
    ..The functional blocking of PU.1 by C/EBPalpha could be the mechanism by which C/EBPalpha inhibits cell fates specified by PU.1 and directs cell development to the granulocyte lineage...
  39. Wu C, Biernacki M, Kutok J, Rogers S, Chen L, Yang X, et al. Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells. Clin Cancer Res. 2005;11:4504-11 pubmed
    ..The present studies characterize expression of CML28 and CML66 in primary hematopoietic tissues...
  40. Briggs R, Shults K, Flye L, McClintock Treep S, Jagasia M, Goodman S, et al. Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. Cancer Res. 2006;66:4645-51 pubmed
    ..We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to ..
  41. Conaway H, Persson E, Halén M, Granholm S, Svensson O, Pettersson U, et al. Retinoids inhibit differentiation of hematopoietic osteoclast progenitors. FASEB J. 2009;23:3526-38 pubmed publisher
    ..The results suggest that activation of RARalpha by retinoids in myeloid hematopoietic precursor cells decreases osteoclast formation by altering expression of the transcription factors c-Fos, NFAT2, and MafB. ..
  42. Fatrai S, Wierenga A, Daenen S, Vellenga E, Schuringa J. Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells. Blood. 2011;117:3320-30 pubmed publisher
    ..Our studies indicate that pathways normally activated under hypoxia might be used by STAT5 under higher oxygen conditions to maintain and/or impose HSC self-renewal properties. ..
  43. Wong W, Boutros P, Wasylishen A, Guckert K, O Brien E, Griffiths R, et al. Characterization of the apoptotic response of human leukemia cells to organosulfur compounds. BMC Cancer. 2010;10:351 pubmed publisher
    ..0001). Taken together, these data establish OSCs derivatized from dysoxysulfone as a novel group of compounds for development as anti-cancer agents. ..
  44. Ren Y, Chen Z, Chen L, Woods N, Reuther G, Cheng J, et al. Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. J Biol Chem. 2007;282:36463-73 pubmed
    ..Furthermore, Shp2E76K induces cytokine-independent survival of TF-1 cells by a novel mechanism involving up-regulation of Bcl-XL through the Erk1/2 pathway. ..
  45. Schuettpelz L, Gopalan P, Giuste F, Romine M, van Os R, Link D. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012;120:2981-9 pubmed publisher
  46. Karamitros D, Stoilova B, Aboukhalil Z, Hamey F, Reinisch A, Samitsch M, et al. Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. Nat Immunol. 2018;19:85-97 pubmed publisher
    ..Those findings, coupled with single-cell expression analyses, suggest that a continuum of progenitors execute lymphoid and myeloid differentiation, rather than only uni-lineage progenitors' being present downstream of stem cells. ..
  47. Song C, Yuan Y, Wang X, Li D, Zhang G, Huang B, et al. Passive transfer of tumour-derived MDSCs inhibits asthma-related airway inflammation. Scand J Immunol. 2014;79:98-104 pubmed publisher
    ..Based on the collective results, we propose that asthma may be effectively targeted using a novel MDSC-based cell therapy approach. ..
  48. Putman D, Cooper T, Sherman S, Seneviratne A, Hewitt M, Bell G, et al. Expansion of Umbilical Cord Blood Aldehyde Dehydrogenase Expressing Cells Generates Myeloid Progenitor Cells that Stimulate Limb Revascularization. Stem Cells Transl Med. 2017;6:1607-1619 pubmed publisher
    ..Stem Cells Translational Medicine 2017;6:1607-1619...
  49. Liongue C, Hall C, O Connell B, Crosier P, Ward A. Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration. Blood. 2009;113:2535-46 pubmed publisher
  50. Yan J, Chen S, Zhang Y, Li X, Li Y, Wu X, et al. Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1. Hum Mol Genet. 2008;17:936-48 pubmed
    ..Collectively, these data demonstrate that Rac1 critically contributes to increased osteoclast function induced by haploinsufficiency of Nf1 and implicate Rac1 as a rational therapeutic target for osteoporosis. ..
  51. Wang G, Calvo K, Pasillas M, Sykes D, Hacker H, Kamps M. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods. 2006;3:287-93 pubmed
    ..Using knockout or small interfering RNA (siRNA) technologies, this ER-Hoxb8 phagocyte maturation system represents a rapid analytical tool for studying macrophage and neutrophil biology. ..
  52. Lu J, Hsieh M, Hou H, Chen C, Tien H, Lin L. Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood Cancer J. 2017;7:e593 pubmed publisher
    ..of age, their kidney structure was significantly effaced and distorted by increased infiltration of myeloid progenitor cells. These results suggest that SOX4 is not only an independent prognostic factor of AML, but also an ..
  53. Vink P, Smout W, Driessen Engels L, de Bruin A, Delsing D, Krajnc Franken M, et al. In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. PLoS ONE. 2013;8:e57348 pubmed publisher
    ..cells in the bone marrow upon doxycycline treatment showed increased proliferation and differentiation of myeloid progenitor cells. Given the similarity of the phenotype with TGF-β genetic models, our data suggest that in our model ..
  54. Solves P, López M, Mirabet V, Blanquer A, Roig R, Perales A. Characteristics of umbilical cord blood units collected from preterm deliveries. Gynecol Obstet Invest. 2009;68:181-5 pubmed publisher
    ..Our aim was to analyse the UCB characteristics of UCB units from preterm deliveries and compare them to full-term deliveries...
  55. Yang J, Ryu Y, Yun C, Han S. Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88. J Leukoc Biol. 2009;86:823-31 pubmed publisher
    ..These results suggest that staphylococcal LTA inhibits osteoclast differentiation primarily through TLR2 but also in part through MyD88 signaling, which in turn, inhibits activation of ERK, JNK, and AP-1...
  56. Yamamura K, Ohishi K, Katayama N, Kato K, Shibasaki T, Sugimoto Y, et al. Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor alpha-positive and -negative human hematopoietic progenitors. Cancer Sci. 2007;98:1597-603 pubmed
    ..The present data suggest a divergent interaction between Delta-1 and gp130 activation in human hematopoiesis...
  57. Costantini A, Giuliodoro S, Butini L, Silvestri G, Leoni P, Montroni M. HIV-induced abnormalities in myelopoiesis and their recovery following antiretroviral therapy. Curr HIV Res. 2010;8:336-9 pubmed
    ..ART-induced suppression of HIV-1 replication is associated with normalization of CFU-GM levels...
  58. Kitajima K, Tanaka M, Zheng J, Yen H, Sato A, Sugiyama D, et al. Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2. Blood. 2006;107:1857-63 pubmed
    ..1 promoter region. This study demonstrates that the function of GATA-2 is modified in a context-dependent manner by expression of PU.1, which in turn is regulated by GATA-2...
  59. Knoll M, Simmons S, Bouquet C, Grün J, Melchers F. miR-221 redirects precursor B cells to the BM and regulates their residence. Eur J Immunol. 2013;43:2497-506 pubmed publisher
    ..Microarray analyses identified 25 downregulated miR-221-target genes, which could function to localize phases of B-lymphocyte development in BM before and after commitment. ..
  60. Marolda R, Ruocco C, Cordiglieri C, Toscani C, Antozzi C, Mantegazza R, et al. Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravis. J Neuroimmunol. 2013;258:41-50 pubmed publisher
    ..Our data further demonstrate that Pixantrone is a promising immunosuppressant drug that should be investigated in myasthenia gravis...
  61. Konieczna I, Panuganti S, Deluca T, Papoutsakis E, Eklund E, Miller W. Administration of nicotinamide does not increase platelet levels in mice. Blood Cells Mol Dis. 2013;50:171-6 pubmed publisher
    ..Together, our results suggest that, although nicotinamide increases polyploidization of megakaryocytes in culture, it does not have translatable effects in vivo...
  62. Periasamy P, Tan J, Griffiths K, O Neill H. Splenic stromal niches support hematopoiesis of dendritic-like cells from precursors in bone marrow and spleen. Exp Hematol. 2009;37:1060-71 pubmed publisher
    ..The aims of this study are to test the ability of stromal cells from murine spleen to support hematopoiesis, to define the tissue source of precursors that seed these hematopoietic niches, and to determine the type of cells produced...
  63. Yang G, Lian Z, Chuang Y, Shu S, Moritoki Y, Lan R, et al. Generation of functionally distinct B lymphocytes from common myeloid progenitors. Clin Exp Immunol. 2007;150:349-57 pubmed
    ..Together, these data suggest the existence of multiple pathways for generating functionally distinct B cells from bone marrow precursors...
  64. Lai A, Kondo M. Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. J Exp Med. 2006;203:1867-73 pubmed
    ..Our results suggest that the first step of lineage commitment from HSCs is not simply a selection between the lymphoid and the myeloid lineage...
  65. Mahdipour E, Mace K. Analyzing the angiogenic potential of Gr-1(+)CD11b (+) immature myeloid cells from murine wounds. Methods Mol Biol. 2012;916:219-29 pubmed publisher
    ..This chapter provides methods by which one can isolate these cells from wound tissue and assess their pro-angiogenic capacity via gene expression analyses and functional in vivo angiogenesis assays...
  66. Dai Z, Yan G, Chen Y, Liu W, Huo Z, Wen Z, et al. [Forward genetic screening for zebrafish mutants defective in myelopoiesis]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1230-3 pubmed
    ..To identify zebrafish mutants with myelopoiesis defects by ENU mutagenesis and large-scale forward genetic screening...
  67. Miranda M, Xu H, Torchia J, Johnson D. Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk Res. 2005;29:1293-306 pubmed
    ..Taken together, these studies demonstrate an important requirement for MEK/ERK activation during cytokine-induced granulocytic and monocytic differentiation...