lymphoid progenitor cells
Summary: Stem cells from which B-LYMPHOCYTES; T-LYMPHOCYTES; NATURAL KILLER CELLS; and some DENDRITIC CELLS derive.
Dorshkind K. Not a split decision for human hematopoiesis. Nat Immunol. 2010;11:569-70 pubmed publisher
Lebert Ghali C, Thompson A, Melichar H, Bijl J. Targeted deletion of the Hoxa cluster affects B lymphopoiesis through depletion of early lymphoid progenitors. Exp Hematol. 2017;50:84-89.e3 pubmed publisher
..Together, these results suggest that the effect of Hoxa on B-cell development originates in early lymphoid progenitor cells.
Ghosh D, Brown S, Stumhofer J. IL-17 Promotes Differentiation of Splenic LSK- Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection. J Immunol. 2017;199:1783-1795 pubmed publisher
..Together, these results identify a distinct pathway that supports lymphoid development in the spleen during acute Plasmodium infection. ..
Alhaj Hussen K, Vu Manh T, Guimiot F, Nelson E, Chabaane E, Delord M, et al
. Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis. Immunity. 2017;47:680-696.e8 pubmed publisher
..On the basis of these results, we propose a "two-family" model of human lymphoid development that differs from the prevailing model of hematopoiesis. ..
Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore A, et al
. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017;46:818-834.e4 pubmed publisher
..On the basis of these and previous observations, we propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate. ..
Horton S, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford Rogers R, et al
. Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nat Cell Biol. 2017;19:1093-1104 pubmed publisher
..These data suggest that earlier loss of Crebbp is advantageous for lymphoid transformation and inform the cellular origins and subsequent evolution of lymphoid malignancies. ..
Berthault C, Ramond C, Burlen Defranoux O, Soubigou G, Chea S, Golub R, et al
. Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver. Nat Immunol. 2017;18:1139-1149 pubmed publisher
..of these two subsets were sequentially upregulated in lympho-myeloid precursor cells and in common lymphoid progenitor cells, respectively, and this preceded lineage restriction; this indicates that T cell-versus-B cell ..
Xiao S, Shterev I, Zhang W, Young L, Shieh J, Moore M, et al
. Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors. J Immunol. 2017;199:2701-2712 pubmed publisher
..Our findings may impact evaluation and therapeutic intervention of human TBI events. ..
Odhams C, Cunninghame Graham D, Vyse T. Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease. PLoS Genet. 2017;13:e1007071 pubmed publisher
..Many of the known and novel genes were concealed at gene-level (e.g. IKZF2, TYK2, LYST). Our findings are provided as a web resource. ..