hematopoietic stem cells


Summary: Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.

Top Publications

  1. Lockridge J, Zhou Y, Becker Y, Ma S, Kenney S, Hematti P, et al. Mice engrafted with human fetal thymic tissue and hematopoietic stem cells develop pathology resembling chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2013;19:1310-22 pubmed publisher
    ..This model thus provides a new system to investigate disease pathophysiology relating to human thymic events and to evaluate treatment strategies to combat multiorgan fibrotic pathology produced by human immune cells. ..
  2. Staber P, Zhang P, Ye M, Welner R, Nombela Arrieta C, Bach C, et al. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell. 2013;49:934-46 pubmed publisher
    To provide a lifelong supply of blood cells, hematopoietic stem cells (HSCs) need to carefully balance both self-renewing cell divisions and quiescence...
  3. Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph K, et al. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell. 2013;154:1112-1126 pubmed publisher
    Consensus holds that hematopoietic stem cells (HSCs) give rise to multipotent progenitors (MPPs) of reduced self-renewal potential and that MPPs eventually produce lineage-committed progenitor cells in a stepwise manner...
  4. Sandler V, Lis R, Liu Y, Kedem A, James D, Elemento O, et al. Reprogramming human endothelial cells to haematopoietic cells requires vascular induction. Nature. 2014;511:312-8 pubmed publisher
  5. Riddell J, Gazit R, Garrison B, Guo G, Saadatpour A, Mandal P, et al. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 2014;157:549-64 pubmed publisher
    b>Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the functional units of bone marrow transplantation...
  6. de Laval B, Pawlikowska P, Barbieri D, Besnard Guerin C, Cico A, Kumar R, et al. Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-?B pathways and their target, IEX-1. Blood. 2014;123:509-19 pubmed publisher
    ..Iex-1 forms a complex with pERK and the catalytic subunit of DNA-PK, which is necessary and sufficient to promote TPO-increased DNA-PK activation and NHEJ DSB repair in both mouse and human HSPCs. ..
  7. Zhu Y, Wang D, Wang F, Li T, Dong L, Liu H, et al. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Res. 2013;41:4129-43 pubmed publisher
    ..Furthermore, a protein tyrosine phosphatase, SHP2, was identified as a downstream target of miR-23a that mediated its regulation of erythropoiesis. Taken together, our data identify a key GATA-1-miRNA axis in erythroid differentiation...
  8. Ou X, O Leary H, Broxmeyer H. Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types. Blood. 2013;122:161-9 pubmed publisher
  9. Chou S, Flygare J, Lodish H. Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells. Exp Hematol. 2013;41:479-490.e4 pubmed publisher
    ..In contrast, DLK(-) cells are incapable of expanding hematopoietic cells, demonstrating that hepatic progenitors are the principle supportive cells for HSC expansion in the fetal liver. ..

More Information


  1. Ye M, Zhang H, Amabile G, Yang H, Staber P, Zhang P, et al. C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nat Cell Biol. 2013;15:385-94 pubmed publisher
    ..Mechanistically we identified N-Myc as a downstream target of C/EBPa, and loss of C/EBPa resulted in de-repression of N-Myc. Our data establish C/EBPa as a central determinant in the switch from fetal to adult HSCs. ..
  2. Goto M, Kuribayashi K, Takahashi Y, Kondoh T, Tanaka M, Kobayashi D, et al. Identification of autoantibodies expressed in acquired aplastic anaemia. Br J Haematol. 2013;160:359-62 pubmed publisher
    ..This study indicates that haematopoietic cells are the targets of immune abnormality in aAA. These autoantibodies may be utilized to distinguish patients associated with immune abnormality from bone marrow failure syndrome. ..
  3. Biffi A, Montini E, Lorioli L, Cesani M, Fumagalli F, Plati T, et al. Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science. 2013;341:1233158 pubmed publisher
    ..We used a lentiviral vector to transfer a functional ARSA gene into hematopoietic stem cells (HSCs) from three presymptomatic patients who showed genetic, biochemical, and neurophysiological ..
  4. Lu X, Li X, He Q, Gao J, Gao Y, Liu B, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res. 2013;23:1356-68 pubmed publisher
    ..Here, we show that in zebrafish and mouse, miR-142-3p is specifically expressed in hematopoietic stem cells (HSCs)...
  5. Goto Koshino Y, Fukuchi Y, Shibata F, Abe D, Kuroda K, Okamoto S, et al. Robo4 plays a role in bone marrow homing and mobilization, but is not essential in the long-term repopulating capacity of hematopoietic stem cells. PLoS ONE. 2012;7:e50849 pubmed publisher
    ..role of Robo4 in hematopoiesis, we examined the effects of Robo4 disruption on the function of hematopoietic stem cells (HSCs) and progenitors...
  6. Verovskaya E, Broekhuis M, Zwart E, Ritsema M, van Os R, de Haan G, et al. Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding. Blood. 2013;122:523-32 pubmed publisher
    The number of hematopoietic stem cells (HSCs) that contributes to blood formation and the dynamics of their clonal contribution is a matter of ongoing discussion...
  7. Insinga A, Cicalese A, Faretta M, Gallo B, Albano L, Ronzoni S, et al. DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions. Proc Natl Acad Sci U S A. 2013;110:3931-6 pubmed publisher
    ..These findings suggest that stem cells have evolved a unique, p21-dependent response to DNA damage that leads to their immediate expansion and limits their long-term survival. ..
  8. Shin J, Hu W, Naramura M, Park C. High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias. J Exp Med. 2014;211:217-31 pubmed publisher
    b>Hematopoietic stem cells (HSCs) are heterogeneous with respect to their self-renewal, lineage, and reconstitution potentials...
  9. Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, et al. Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem. 2013;288:34719-28 pubmed publisher
  10. Senyuk V, Zhang Y, Liu Y, Ming M, Premanand K, Zhou L, et al. Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis. Proc Natl Acad Sci U S A. 2013;110:5594-9 pubmed publisher
    ..Here we show that miR-9 is detected in hematopoietic stem cells and hematopoietic progenitor cells, and that its expression increases during hematopoietic ..
  11. Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, et al. Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation. Mol Ther. 2013;21:1424-31 pubmed publisher
    In vitro generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) has the potential to provide novel therapeutic approaches for replacing bone marrow (BM) transplantation without rejection or graft versus ..
  12. Nixon C, Vatakis D, Reichelderfer S, Dixit D, Kim S, Uittenbogaart C, et al. HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice. Blood. 2013;122:2195-204 pubmed publisher
    ..Further, the nonobese diabetic severe combined immunodeficiency common ? chain knockout-bone marrow-liver-thymus humanized mouse provides a unique model for studying the impact of HIV infection on bone marrow-based human hematopoiesis. ..
  13. McNamara L, Onafuwa Nuga A, Sebastian N, Riddell J, Bixby D, Collins K. CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression. J Infect Dis. 2013;207:1807-16 pubmed publisher
    ..HIV genomes can be detected in CD133-sorted cells from a subset of donors with long-term viral suppression and, in most cases, cannot be explained by contamination with CD3(+) T cells. ..
  14. Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, et al. SIRT3 reverses aging-associated degeneration. Cell Rep. 2013;3:319-27 pubmed publisher
    ..acetylation landscape of mitochondrial proteins and reduces oxidative stress, is highly enriched in hematopoietic stem cells (HSCs) where it regulates a stress response...
  15. Bogani C, Bartalucci N, Martinelli S, Tozzi L, Guglielmelli P, Bosi A, et al. mTOR inhibitors alone and in combination with JAK2 inhibitors effectively inhibit cells of myeloproliferative neoplasms. PLoS ONE. 2013;8:e54826 pubmed publisher
    ..The aim of the study was to characterize the effects in vitro of mTOR inhibitors, used alone and in combination with JAK2 inhibitors, against MPN cells...
  16. Younan P, Polacino P, Kowalski J, Peterson C, Maurice N, Williams N, et al. Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model. Blood. 2013;122:179-87 pubmed publisher
    ..In 2009, an HIV(+) patient was effectively cured of HIV following allogeneic transplantation of hematopoietic stem cells (HSCs) from a CCR5(-/-) donor...
  17. Saito Y, Kaneda K, Suekane A, Ichihara E, Nakahata S, Yamakawa N, et al. Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. Leukemia. 2013;27:1637-49 pubmed publisher
    ..Moreover, in Gpr56(-/-) mice, the number of hematopoietic stem cells (HSCs) was significantly decreased in the bone marrow (BM) and, conversely, was increased in the spleen, ..
  18. Mossadegh Keller N, Sarrazin S, Kandalla P, Espinosa L, Stanley E, Nutt S, et al. M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature. 2013;497:239-43 pubmed publisher
    ..This fundamentally changes the current view of how HSCs respond to environmental challenge and implicates stress-induced cytokines as direct instructors of HSC fate. ..
  19. Mendelsohn A, Larrick J. Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic?. Rejuvenation Res. 2013;16:152-7 pubmed publisher
    ..Striking evidence that increased oxidative stress associated with hematopoietic stem cells (HSCs) from aging mice causes dysfunction has been reported...
  20. Zhang Y, Duc A, Rao S, Sun X, Bilbee A, Rhodes M, et al. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell. 2013;24:411-25 pubmed publisher
    ..In contrast, knockdown of the Rpl22 paralog, Rpl22l1, impairs the emergence of hematopoietic stem cells (HSC) in the aorta-gonad-mesonephros by abrogating Smad1 expression and the consequent induction of ..
  21. Ran D, Shia W, Lo M, Fan J, Knorr D, Ferrell P, et al. RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood. 2013;121:2882-90 pubmed publisher
    ..Together, our results suggest that RUNX1a facilitates the process of producing therapeutic HPCs from hPSCs. ..
  22. Maziarz R, Nademanee A, Micallef I, Stiff P, Calandra G, Angell J, et al. Plerixafor plus granulocyte colony-stimulating factor improves the mobilization of hematopoietic stem cells in patients with non-Hodgkin lymphoma and low circulating peripheral blood CD34+ cells. Biol Blood Marrow Transplant. 2013;19:670-5 pubmed publisher
    ..These findings may provide insight into the optimal use of plerixafor in all patients undergoing stem cell mobilization. ..
  23. Deshpande S, Bosbach B, Yozgat Y, Park C, Moore M, Besmer P. KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion. Stem Cells. 2013;31:1683-95 pubmed publisher
    ..Our study demonstrates that signaling from the Kit(V558?;T669I/+) receptor has important consequences in hematopoiesis enhancing HSC self-renewal and resulting in increased erythropoiesis. ..
  24. Wilkinson F, Sergijenko A, Langford Smith K, Malinowska M, Wynn R, Bigger B. Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation. Mol Ther. 2013;21:868-76 pubmed publisher
    ..This has implications for the choice of conditioning regimen to promote hematopoietic cell brain engraftment and the relevance of irradiation in mouse models of transplantation...
  25. Nombela Arrieta C, Pivarnik G, Winkel B, Canty K, Harley B, Mahoney J, et al. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013;15:533-43 pubmed publisher
    ..These studies argue that the characteristic hypoxic state of HSPCs is not solely the result of a minimally oxygenated niche but may be partially regulated by cell-specific mechanisms. ..
  26. Graham M, Abram C, Hu Y, Lowell C. Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice. PLoS ONE. 2013;8:e77542 pubmed publisher
    ..These data indicate that expression of TEL-Syk in fetal liver hematopoietic cells results in JAK-independent STAT5 phosphorylation ultimately leading to a uniquely aggressive and lethal form of myelofibrosis. ..
  27. Klauke K, Radulović V, Broekhuis M, Weersing E, Zwart E, Olthof S, et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol. 2013;15:353-62 pubmed publisher
    ..Taken together, the presence of distinct Cbx proteins confers target selectivity to PRC1 and provides a molecular balance between self-renewal and differentiation of HSCs. ..
  28. Gustafsson K, Heffner G, Wenzel P, Curran M, Grawe J, McKinney Freeman S, et al. The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp Cell Res. 2013;319:1852-64 pubmed publisher
    ..Shb deficient bone marrow contained reduced relative numbers of long-term hematopoietic stem cells (LT-HSCs) that exhibited lower proliferation rates...
  29. Li Z, Lan Y, He W, Chen D, Wang J, Zhou F, et al. Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell. 2012;11:663-75 pubmed publisher
    ..AGM) region is considered to be the sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we report that, in parallel to the AGM region, the E10.5-E11...
  30. Gekas C, Graf T. CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age. Blood. 2013;121:4463-72 pubmed publisher
    ..In summary, our data provide a novel marker to identify a myeloid-biased HSC subtype that becomes prevalent with age and highlights the dogma of HSC regulation by their progeny...
  31. Akhter S, Rahman M, Lee H, Kim H, Hong S. Dynamic roles of angiopoietin-like proteins 1, 2, 3, 4, 6 and 7 in the survival and enhancement of ex vivo expansion of bone-marrow hematopoietic stem cells. Protein Cell. 2013;4:220-30 pubmed publisher
    Recent advances in hematopoietic stem cells (HSCs) expansion by growth factors including angiopoietin-like proteins (Angptls) have opened up the possibility to use HSCs in regenerative medicine...
  32. Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502:637-43 pubmed publisher
    ..Conditional depletion of NG2(+) cells induces HSC cycling and reduces functional long-term repopulating HSCs in the bone marrow. These results thus indicate that arteriolar niches are indispensable for maintaining HSC quiescence. ..
  33. Le Bouteiller M, Souilhol C, Beck Cormier S, Stedman A, Burlen Defranoux O, Vandormael Pournin S, et al. Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. J Exp Med. 2013;210:2351-69 pubmed publisher
    Blood cell production relies on the coordinated activities of hematopoietic stem cells (HSCs) and multipotent and lineage-restricted progenitors...
  34. Frelin C, Herrington R, Janmohamed S, Barbara M, Tran G, Paige C, et al. GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nat Immunol. 2013;14:1037-44 pubmed publisher
    ..Despite evidence it may also be expressed in multipotent hematopoietic stem cells (HSCs), any role for GATA-3 in these cells has remained unclear...
  35. Karlsson G, Rörby E, Pina C, Soneji S, Reckzeh K, Miharada K, et al. The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells. Cell Rep. 2013;4:642-8 pubmed publisher
    ..Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populations that lack authentic stem cell function...
  36. Richard C, Drevon C, Canto P, Villain G, Bollerot K, Lempereur A, et al. Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Dev Cell. 2013;24:600-11 pubmed publisher
    b>Hematopoietic stem cells (HSCs) are produced by a small cohort of hemogenic endothelial cells (ECs) during development through the formation of intra-aortic hematopoietic cell (HC) clusters...
  37. Brenet F, Kermani P, Spektor R, Rafii S, Scandura J. TGF? restores hematopoietic homeostasis after myelosuppressive chemotherapy. J Exp Med. 2013;210:623-39 pubmed publisher
    ..Although hematopoietic stem cells (HSCs) are predominantly quiescent during homeostasis, they are rapidly recruited into cell cycle by ..
  38. Chiang M, Shestova O, Xu L, Aster J, Pear W. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood. 2013;121:905-17 pubmed publisher
    ..These results provide further evidence for therapeutically targeting T-cell progenitors in T-ALL while also underscoring the need to tightly regulate Notch signaling to expand normal HSC populations for clinical applications...
  39. Hasemann M, Lauridsen F, Waage J, Jakobsen J, Frank A, Schuster M, et al. C/EBP? is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet. 2014;10:e1004079 pubmed publisher
    Transcription factors are key regulators of hematopoietic stem cells (HSCs) and act through their ability to bind DNA and impact on gene transcription...
  40. McKinney Freeman S, Cahan P, Li H, Lacadie S, Huang H, Curran M, et al. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 2012;11:701-14 pubmed publisher
    Transcriptome analysis of adult hematopoietic stem cells (HSCs) and their progeny has revealed mechanisms of blood differentiation and leukemogenesis, but a similar analysis of HSC development is lacking...
  41. Choorapoikayil S, Kers R, Herbomel P, Kissa K, den Hertog J. Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. Blood. 2014;123:184-90 pubmed publisher
    ..We conclude that Pten has an essential role in the balance between proliferation and differentiation of blood cells. ..
  42. Karapetyan A, Klyachkin Y, Selim S, Sunkara M, Ziada K, Cohen D, et al. Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Stem Cells Dev. 2013;22:1645-56 pubmed publisher
    ..sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HSCs), we explored whether they also direct trafficking of non-hematopoietic stem cells (non-HSCs)...
  43. Clements W, Traver D. Signalling pathways that control vertebrate haematopoietic stem cell specification. Nat Rev Immunol. 2013;13:336-48 pubmed publisher
    ..Here, we review current knowledge of the intraembryonic signals required for the specification of HSCs in vertebrates...
  44. Greenbaum A, Hsu Y, Day R, Schuettpelz L, Christopher M, Borgerding J, et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495:227-30 pubmed publisher
  45. Rodríguez Pardo V, Vernot J. Mesenchymal stem cells promote a primitive phenotype CD34+c-kit+ in human cord blood-derived hematopoietic stem cells during ex vivo expansion. Cell Mol Biol Lett. 2013;18:11-33 pubmed publisher
    ..primitive cell subpopulation maintenance (including the c-kit+ marker) and clonogenic capacity of hematopoietic stem cells (HSC). BM-MSC were collected from volunteer donors, isolated and characterized...
  46. Sun Y, Sun J, Tomomi T, Nieves E, Mathewson N, Tamaki H, et al. PU.1-dependent transcriptional regulation of miR-142 contributes to its hematopoietic cell-specific expression and modulation of IL-6. J Immunol. 2013;190:4005-13 pubmed publisher
    ..These results collectively reveal the direct cis-acting sequences of miR-142 specific promoter and that transcription factor PU.1 is necessary for its exclusive expression in hematopoietic cells and regulation of IL-6...
  47. Monzen S, Yoshino H, Kasai Eguchi K, Kashiwakura I. Characteristics of myeloid differentiation and maturation pathway derived from human hematopoietic stem cells exposed to different linear energy transfer radiation types. PLoS ONE. 2013;8:e59385 pubmed publisher
  48. Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun K, et al. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014;211:209-15 pubmed publisher
    Long-term hematopoietic stem cells (HSCs [LT-HSCs]) are well known to display unpredictable differences in their clonal expansion capacities after transplantation...
  49. Marcelo K, SILLS T, Coskun S, Vasavada H, Sanglikar S, Goldie L, et al. Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Dev Cell. 2013;27:504-15 pubmed publisher
    ..Thus, RA regulation of hemogenic endothelial cell specification requires c-Kit, notch signaling, and p27-mediated cell-cycle control...
  50. Chacon D, Beck D, Perera D, Wong J, Pimanda J. BloodChIP: a database of comparative genome-wide transcription factor binding profiles in human blood cells. Nucleic Acids Res. 2014;42:D172-7 pubmed publisher
    ..All queries can be exported into external sites to construct TF-gene and protein-protein networks and to evaluate the association of genes with cellular processes and tissue expression. ..
  51. Funk N, Wieghofer P, Grimm S, Schaefer R, Buhring H, Gasser T, et al. Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease. Mov Disord. 2013;28:392-5 pubmed publisher
    ..This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients.
  52. Nayak R, Chang K, Vaitinadin N, Cancelas J. Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunol Rev. 2013;256:255-68 pubmed publisher
    ..signaling pathways previously seen in other cell types and organisms have been confirmed in mammalian hematopoietic stem cells (HSCs), and new signaling pathways and unexpected functions unique to HSCs have been identified and ..
  53. Zhao Y, Ling F, Wang H, Sun X. Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice. PLoS ONE. 2013;8:e55552 pubmed publisher
    b>Hematopoietic stem cells (HSCs) maintain life-long blood supply but are inevitably exposed to various inflammatory stimuli, which have been shown to be harmful for HSC integrity but the mediators of the deleterious effects have not been ..
  54. Beck D, Thoms J, Perera D, Schütte J, Unnikrishnan A, Knezevic K, et al. Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes. Blood. 2013;122:e12-22 pubmed publisher
    ..Taken together, these data reveal the power of integrating multifactor sequencing of chromatin immunoprecipitates with coding and noncoding gene expression to identify regulatory circuits controlling cell identity. ..
  55. Sanjuan Pla A, Macaulay I, Jensen C, Woll P, Luis T, Mead A, et al. Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. Nature. 2013;502:232-6 pubmed publisher
    ..The identification of a platelet-primed HSC population should enable the rational design of therapies enhancing platelet output...
  56. Gordon Keylock S, Sobiesiak M, Rybtsov S, Moore K, Medvinsky A. Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs. Blood. 2013;122:2338-45 pubmed publisher
    During mouse development, definitive hematopoietic stem cells (dHSCs) emerge by late E10.5 to E11 in several hematopoietic sites...
  57. Joshi A, Hannah R, Diamanti E, Göttgens B. Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data. Exp Hematol. 2013;41:354-66.e14 pubmed publisher
    ..To facilitate access to the wider research community, we have implemented GSCA as a freely accessible web tool (http://bioinformatics.cscr.cam.ac.uk/GSCA/GSCA.html). ..
  58. de Laval B, Pawlikowska P, Petit Cocault L, Bilhou Nabera C, Aubin Houzelstein G, Souyri M, et al. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell. 2013;12:37-48 pubmed publisher
    DNA double-strand breaks (DSBs) represent a serious threat for hematopoietic stem cells (HSCs)...
  59. Mierzejewska K, Heo J, Kang J, Kang H, Ratajczak J, Ratajczak M, et al. Genome-wide analysis of murine bone marrow?derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. Int J Mol Med. 2013;32:281-90 pubmed publisher
    ..microarray database established from 20 murine bone marrow-derived, FACS-sorted VSELs in comparison with hematopoietic stem cells and embryonic stem cells...
  60. Li L, Krymskaya L, Wang J, Henley J, Rao A, Cao L, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013;21:1259-69 pubmed publisher
    ..occurring CCR5 deletion mutation (CCR5(?32/?32)) supports the concept that a single dose of HIV-resistant hematopoietic stem cells can provide disease protection...
  61. Van Zant G, Liang Y. Concise review: hematopoietic stem cell aging, life span, and transplantation. Stem Cells Transl Med. 2012;1:651-7 pubmed publisher
    ..proinflammation, and anemia, is attributed to age-associated changes in the number and function of hematopoietic stem cells (HSCs) and their microenvironmental niche...
  62. Yan Z, Zeng L, Li Z, Zhang H, Chen W, Jia L, et al. Bone marrow-derived endothelial progenitor cells promote hematopoietic reconstitution after hematopoietic stem cell transplantation. Transplant Proc. 2013;45:427-33 pubmed publisher
    ..This study investigated whether EPCs from bone marrow (BM) of adult mice could promote hematopoietic reconstitution...
  63. Guiu J, Shimizu R, D Altri T, Fraser S, Hatakeyama J, Bresnick E, et al. Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med. 2013;210:71-84 pubmed publisher
  64. Jagannathan Bogdan M, Zon L. Hematopoiesis. Development. 2013;140:2463-7 pubmed publisher
    ..Here, we provide a broad overview of vertebrate hematopoiesis. We also highlight the benefits of using zebrafish as a model...
  65. Hidalgo I, Herrera Merchan A, Ligos J, Carramolino L, Nunez J, Martinez F, et al. Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest. Cell Stem Cell. 2012;11:649-62 pubmed publisher
    ..Deletion of Cdkn2a on the Ezh1 null background rescued HSC proliferation and survival. Our results suggest that Ezh1 is an important histone methyltransferase for HSC maintenance...
  66. DeMicco A, Yang Iott K, Bassing C. Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations. Cell Cycle. 2013;12:3307-16 pubmed publisher
    ..of B lineage tumors in mice, we generated and analyzed mice with conditional Tp53 deletion initiating in hematopoietic stem cells (HSCs) or in lineage-committed thymocytes...
  67. Böiers C, Carrelha J, Lutteropp M, Luc S, Green J, Azzoni E, et al. Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells. Cell Stem Cell. 2013;13:535-48 pubmed publisher
    ..whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs)...
  68. Doan P, Russell J, Himburg H, Helms K, Harris J, Lucas J, et al. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells. 2013;31:327-37 pubmed publisher
    b>Hematopoietic stem cells (HSCs) reside in proximity to bone marrow endothelial cells (BM ECs) and maintenance of the HSC pool is dependent upon EC-mediated c-kit signaling...
  69. Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, et al. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood. 2013;121:1316-25 pubmed publisher
    ..Our data show that efficient human cell engraftment found in NOD-based models is mounted solely by their polymorphic Sirpa. The simplified BRGS line should be very useful in future studies of human stem cell biology...
  70. Ergen A, Jeong M, Lin K, Challen G, Goodell M. Isolation and characterization of mouse side population cells. Methods Mol Biol. 2013;946:151-62 pubmed publisher
    ..In this chapter we describe a detailed protocol for the purification of murine bone marrow SP cells based on Hoechst dye efflux in combination with the presence of HSC surface markers. ..
  71. Choudhary R, Baturin D, Fosmire S, Freed B, Porter C. Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cells. PLoS ONE. 2013;8:e59594 pubmed publisher
    ..Together, these data suggest that human HPC can be programmed to be resistant to purine analogs, but that HPRT knockdown/6TG-based selection may not be robust enough for in vivo selection...
  72. de Bruin A, Demirel O, Hooibrink B, Brandts C, Nolte M. Interferon-? impairs proliferation of hematopoietic stem cells in mice. Blood. 2013;121:3578-85 pubmed publisher
  73. Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, et al. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells. Proc Natl Acad Sci U S A. 2013;110:5582-7 pubmed publisher
    ..cells, and it is widely used as a cell surface marker for the isolation and characterization of human hematopoietic stem cells (HSCs) and cancer stem cells...
  74. Oguro H, Ding L, Morrison S. SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell. 2013;13:102-16 pubmed publisher
    b>Hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) are routinely isolated using various markers but remain heterogeneous...
  75. Li B, Gan T, Meyerson M, Rabbitts T, Ernst P. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood. 2013;122:2039-46 pubmed publisher
    ..However, wild-type MLL1 plays a critical role in sustaining hematopoietic stem cells (HSCs); therefore, disruption of an essential MLL1 cofactor would be expected to obliterate normal ..
  76. Soehnlein O, Swirski F. Hypercholesterolemia links hematopoiesis with atherosclerosis. Trends Endocrinol Metab. 2013;24:129-36 pubmed publisher
    ..Here we review some of the studies that are forging this particular link between metabolism and inflammation, and propose several strategies that could target this axis for the treatment of cardiovascular disease...
  77. Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess P, Dean G, et al. TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS ONE. 2012;7:e51073 pubmed publisher
    ..Here we characterized hematopoietic stem cells (HSCs) harboring deletion of Tak1 and its activators, Tak1 binding proteins 1 and 2 (Tab1 and Tab2) using ..
  78. Ogawa M, LaRue A, Mehrotra M. Hematopoietic stem cells are pluripotent and not just "hematopoietic". Blood Cells Mol Dis. 2013;51:3-8 pubmed publisher
    ..the striking concept of the tissue-reconstituting ability (often referred to as HSC plasticity) of hematopoietic stem cells (HSCs)...
  79. Ding L, Morrison S. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013;495:231-5 pubmed publisher
    ..Different stem and progenitor cells thus reside in distinct cellular niches in bone marrow: HSCs occupy a perivascular niche and early lymphoid progenitors occupy an endosteal niche...
  80. Nei Y, Obata Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, et al. GATA-1 regulates the generation and function of basophils. Proc Natl Acad Sci U S A. 2013;110:18620-5 pubmed publisher
    ..Our findings demonstrate that GATA-1 plays a key role in the generation and function of basophils and underscore the need for careful distinction of the cell lineage responsible for each phenotype observed in ?dblGATA mice. ..
  81. Slukvin I. Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood. 2013;122:4035-46 pubmed publisher
    ..the molecular and cellular pathways leading to blood development from hPSCs and discuss potential approaches that can be taken to facilitate the development of technologies for de novo production of hematopoietic stem cells.
  82. Chanda B, Ditadi A, Iscove N, Keller G. Retinoic acid signaling is essential for embryonic hematopoietic stem cell development. Cell. 2013;155:215-27 pubmed publisher
    b>Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial cells known as hemogenic endothelium (HE)...
  83. Bakker S, Passegue E. Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells. Exp Hematol. 2013;41:915-23 pubmed publisher
    Blood homeostasis is maintained by a rare population of quiescent hematopoietic stem cells (HSCs) that self-renew and differentiate to give rise to all lineages of mature blood cells...
  84. Lee J, Shieh J, Zhang J, Liu L, Zhang Y, Eom J, et al. Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4. Blood. 2013;121:4082-9 pubmed publisher
    Direct transduction of the homeobox (HOX) protein HOXB4 promotes the proliferation of hematopoietic stem cells (HSCs) without induction of leukemogenesis, but requires frequent administration to overcome its short protein half-life (?1 ..
  85. Feng Y, Schouteden S, Geenens R, Van Duppen V, Herijgers P, Holvoet P, et al. Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice. PLoS ONE. 2012;7:e47286 pubmed publisher
    ..Recently, studies have suggested that HDL cholesterol may inhibit and impaired cholesterol efflux may increase HSPC proliferation and differentiation...
  86. Sevilla J, Guillén M, Castillo A, Prudencio M, Gonzalez Vicent M, Lassaletta A, et al. Defining "poor mobilizer" in pediatric patients who need an autologous peripheral blood progenitor cell transplantation. Cytotherapy. 2013;15:132-7 pubmed publisher
    ..In these patients, we should consider mobilization with high dose G-CSF and be prepared with new mobilization agents to avoid delay on their course of chemotherapy...
  87. Ringpis G, Shimizu S, Arokium H, Camba Colón J, Carroll M, Cortado R, et al. Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice. PLoS ONE. 2012;7:e53492 pubmed publisher
    ..These results demonstrate that transplantation of HSPCs engineered with our combination shRNA vector may be a potential therapy against HIV disease. ..
  88. Hazra S, Jarajapu Y, Stepps V, Caballero S, Thinschmidt J, Sautina L, et al. Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. Diabetologia. 2013;56:644-53 pubmed publisher
    ..We sought to determine the impact of long-standing type 1 diabetes on haematopoietic stem/progenitor cell (HSC) number and function and to examine the impact of modulating glycoprotein (GP)130 receptor in these cells...