tumor infiltrating lymphocytes

Summary

Summary: Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer.

Top Publications

  1. Guo X, Fan Y, Lang R, Gu F, Chen L, Cui L, et al. Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast. Mod Pathol. 2008;21:1101-7 pubmed publisher
    b>Tumor infiltrating lymphocytes have been correlated with a better prognosis for some tumors and medullary carcinoma of breast is a good example...
  2. Deschoolmeester V, Baay M, Van Marck E, Weyler J, Vermeulen P, Lardon F, et al. Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients. BMC Immunol. 2010;11:19 pubmed publisher
    ..Prognostic relevance was assessed by survival analysis...
  3. Wiech T, Nikolopoulos E, Hausmann M, Walch A, Werner M, Fisch P. A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells. Breast J. 2008;14:487-91 pubmed publisher
    ..whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes. Array comparative genomic hybridization of dissected tumor cells from both components revealed many ..
  4. Xu L, Xu W, Jiang Z, Zhang F, Chu Y, Xiong S. Depletion of CD4(+)CD25(high) regulatory T cells from tumor infiltrating lymphocytes predominantly induces Th1 type immune response in vivo which inhibits tumor growth in adoptive immunotherapy. Cancer Biol Ther. 2009;8:66-72 pubmed
    ..we investigated the enhanced anti-tumor efficacy by adoptive transfer of Treg-depleted autologous tumor infiltrating lymphocytes in advanced murine breast cancer...
  5. Kasper H, Drebber U, Stippel D, Dienes H, Gillessen A. Liver tumor infiltrating lymphocytes: comparison of hepatocellular and cholangiolar carcinoma. World J Gastroenterol. 2009;15:5053-7 pubmed
    To investigate the role of tumor infiltrating lymphocytes (TIL) in primary hepatocellular and cholangiolar carcinomas of the liver.
  6. Nelson B. The impact of T-cell immunity on ovarian cancer outcomes. Immunol Rev. 2008;222:101-16 pubmed publisher
    ..With improved understanding of the functional properties of natural CD8+ T-cell responses to ovarian cancer, there is great potential to improve clinical outcomes by amplifying host immunity...
  7. Piconese S, Valzasina B, Colombo M. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med. 2008;205:825-39 pubmed publisher
    ..In addition, the known OX40-dependent delivery of fitness signals to activated T cells is boosted by concurrent T reg cell inhibition. OX40 triggering thus has multiple effects that converge to mediate tumor rejection...
  8. Loos M, Giese N, Kleeff J, Giese T, Gaida M, Bergmann F, et al. Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer. Cancer Lett. 2008;268:98-109 pubmed publisher
    ..Our findings also suggest a dual role of IFN-gamma in antitumor response. Through induction of B7-H1 in pancreatic cancer cells IFN-gamma might contribute to the evasion of antitumor immunity...
  9. Uppaluri R, Dunn G, Lewis J. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers. Cancer Immun. 2008;8:16 pubmed
    The expanding and established literature that correlates tumor infiltrating lymphocytes (TILs) with outcomes of patients with solid tumors has contributed greatly to the appreciation of the interaction between the host immune system with ..

More Information

Publications64

  1. Clarke B, Tinker A, Lee C, Subramanian S, van de Rijn M, Turbin D, et al. Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. Mod Pathol. 2009;22:393-402 pubmed publisher
    ..The presence of intraepithelial CD8(+) T cells also significantly correlates with loss of BRCA1...
  2. Salama P, Phillips M, Grieu F, Morris M, Zeps N, Joseph D, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol. 2009;27:186-92 pubmed publisher
    ..To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities...
  3. Estrela Lima A, Araújo M, Costa Neto J, Teixeira Carvalho A, Barrouin Melo S, Cardoso S, et al. Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates. BMC Cancer. 2010;10:256 pubmed publisher
    ..The goal of this study was to characterize the clinical-pathological status and the immunophenotyping profile of tumor infiltrating lymphocytes and their association with the animal survival rates in canine mammary carcinomas.
  4. Lepique A, Daghastanli K, Cuccovia I, Villa L. HPV16 tumor associated macrophages suppress antitumor T cell responses. Clin Cancer Res. 2009;15:4391-400 pubmed publisher
    ..The objective of this work is to characterize the role of tumor-associated macrophages (TAM) on the immune cellular response against the tumor...
  5. Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron T, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008;181:3099-107 pubmed
    ..The ability of IR to convert tumors into "inflamed" peripheral tissues could be exploited to overcome obstacles at the effector phase of the antitumor immune response and improve the therapeutic efficacy of immunotherapy...
  6. Heimberger A, Abou Ghazal M, Reina Ortiz C, Yang D, Sun W, Qiao W, et al. Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas. Clin Cancer Res. 2008;14:5166-72 pubmed publisher
    ..Our hypothesis is that only the most malignant gliomas have a prominent glioma-infiltrating Treg population that contributes to the immunosuppressive biology and that the presence of Tregs is a negative prognostic variable...
  7. Sheu B, Kuo W, Chen R, Huang S, Chang K, Chow S. Clinical significance of tumor-infiltrating lymphocytes in neoplastic progression and lymph node metastasis of human breast cancer. Breast. 2008;17:604-10 pubmed publisher
    ..001). Increased percentages of tumor-infiltrating CD8(+) T cells with decreased CD4/CD8 percentages are of prognostic importance for cancer progression in human breast cancer...
  8. Schwitalle Y, Kloor M, Eiermann S, Linnebacher M, Kienle P, Knaebel H, et al. Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterology. 2008;134:988-97 pubmed publisher
    ..However, the role of FSP-specific immune surveillance mechanisms in HNPCC are unknown at present...
  9. Yoshioka T, Miyamoto M, Cho Y, Ishikawa K, Tsuchikawa T, Kadoya M, et al. Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma. Br J Cancer. 2008;98:1258-63 pubmed publisher
    ..Furthermore, Treg numbers correlate with both the CD8/CD4 ratio and the CD4/8 status, suggesting that Treg number is not a factor to predict patient's survival in OSCC...
  10. Hung C, Wu T, Monie A, Roden R. Antigen-specific immunotherapy of cervical and ovarian cancer. Immunol Rev. 2008;222:43-69 pubmed publisher
    ..Here we focus on mesothelin as a promising ovarian TAA, because it is overexpressed and immunogenic at high frequency in patients, is displayed on the cell surface, and potentially contributes to ovarian cancer biology...
  11. Ruffini E, Asioli S, Filosso P, Lyberis P, Bruna M, Macri L, et al. Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms. Ann Thorac Surg. 2009;87:365-71; discussion 371-2 pubmed publisher
    ..We examined prevalence, correlations, and prognostic significance of TIL among our patient population of resected lung neoplasms...
  12. Sfanos K, Bruno T, Maris C, Xu L, Thoburn C, DeMarzo A, et al. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res. 2008;14:3254-61 pubmed publisher
    ..Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer...
  13. Waziri A, Killory B, Ogden A, Canoll P, Anderson R, Kent S, et al. Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma. J Immunol. 2008;180:7673-80 pubmed
    ..We propose that GBM has a unique capacity to recruit and activate CD4(+)CD56(+) T cells, a population that has not been previously described within human tumors...
  14. Anraku M, Cunningham K, Yun Z, Tsao M, Zhang L, Keshavjee S, et al. Impact of tumor-infiltrating T cells on survival in patients with malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2008;135:823-9 pubmed publisher
    ..The aim of the study was to determine the impact of tumor-infiltrating lymphocytes on survival in patients with malignant pleural mesothelioma treated with induction chemotherapy followed by extrapleural pneumonectomy...
  15. Hajimoradi M, Hassan Z, Pourfathollah A, Daneshmandi S, Pakravan N. The effect of shark liver oil on the tumor infiltrating lymphocytes and cytokine pattern in mice. J Ethnopharmacol. 2009;126:565-70 pubmed publisher
    ..Shark Liver Oil (SLO) is a traditional medicine that has been widely used in Scandinavian folk to augment the immune response in some immune-related diseases, especially as an anti-cancer agent...
  16. Richendollar B, Tsao R, Elson P, Jin T, Steinle R, Pohlman B, et al. Predictors of outcome in post-transplant lymphoproliferative disorder: an evaluation of tumor infiltrating lymphocytes in the context of clinical factors. Leuk Lymphoma. 2009;50:2005-12 pubmed publisher
    ..However, on multivariate analysis, clinical factors were the most powerful predictor of PTLD outcome (performance status and CHOP as first line therapy for OS; performance status and number of extranodal sites for both PTLD-SS and PFS)...
  17. Savage P, Vosseller K, Kang C, Larimore K, Riedel E, Wojnoonski K, et al. Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science. 2008;319:215-20 pubmed publisher
    ..Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection...
  18. Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, et al. Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer. Br J Cancer. 2008;98:148-53 pubmed
    ..In conclusion, the localisation pattern, but not the population size, of Foxp3+ cells was significantly related to patient survival...
  19. Lupi I, Manetti L, Caturegli P, Menicagli M, Cosottini M, Iannelli A, et al. Tumor infiltrating lymphocytes but not serum pituitary antibodies are associated with poor clinical outcome after surgery in patients with pituitary adenoma. J Clin Endocrinol Metab. 2010;95:289-96 pubmed publisher
    ..Serum pituitary antibodies (Pit Abs) and tumor-infiltrating lymphocytes (TILs) have been described in pituitary adenomas, but their clinical significance remains unknown...
  20. Garcia Hernandez M, Hamada H, Reome J, Misra S, Tighe M, Dutton R. Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol. 2010;184:4215-27 pubmed publisher
    ..The recruitment of neutrophils was more prominent when Tc17 rather than Tc1 were used to control tumor and depletion of neutrophils resulted in a diminished capacity to control tumor growth...
  21. Mitchell D, Fecci P, Sampson J. Immunotherapy of malignant brain tumors. Immunol Rev. 2008;222:70-100 pubmed publisher
  22. Lee N, Song E, Jang K, Choi H, Moon W, Kwon K, et al. Prognostic impact of tumor infiltrating FOXP3 positive regulatory T cells in diffuse large B-cell lymphoma at diagnosis. Leuk Lymphoma. 2008;49:247-56 pubmed publisher
    ..In conclusion, the presence of an increased percentage of FOXP3-positive Tregs in DLBCL is predictive of better prognoses...
  23. Oble D, Loewe R, Yu P, Mihm M. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma. Cancer Immun. 2009;9:3 pubmed
    Tumors contain variable numbers of lymphocytes, referred to as tumor infiltrating lymphocytes (TILs)...
  24. Tomsova M, Melichar B, Sedláková I, Steiner I. Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma. Gynecol Oncol. 2008;108:415-20 pubmed
    ..The aim of the present study was to investigate the prognostic significance of CD3+ tumor-infiltrating T lymphocytes (TIL) on overall survival of EOC patients...
  25. Yip W, Abdullah M, Yusoff S, Seow H. Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma patients. Clin Exp Immunol. 2009;155:412-22 pubmed publisher
    ..These data provide evidence for the imbalances of T(reg) and effector T cell phenotypes and down-regulation of signal-transducing molecules in TILs, supporting their role in suppression of immune response and immune evasion of NPC...
  26. Denkert C, Loibl S, Noske A, Roller M, Müller B, Komor M, et al. Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol. 2010;28:105-13 pubmed publisher
  27. Callahan M, Nagymanyoki Z, Bonome T, Johnson M, Litkouhi B, Sullivan E, et al. Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer. Clin Cancer Res. 2008;14:7667-73 pubmed publisher
    ..To evaluate the possible mechanisms influencing the infiltration of CD8 T lymphocytes into the tumor epithelium of advanced-stage serous ovarian cancers...
  28. Zhang Y, Li J, Mo H, Qiu F, Zheng L, Qian C, et al. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer. 2010;9:4 pubmed publisher
    Increasing amounts of evidence indicate that tumor infiltrating lymphocytes (TIL) are correlated with the prognosis of cancer patients...
  29. Milne K, Barnes R, Girardin A, Mawer M, Nesslinger N, Ng A, et al. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer. PLoS ONE. 2008;3:e3409 pubmed publisher
    ..We hypothesized that autoantibody and T cell responses may be correlated in EOC and directed toward the same antigens...
  30. Su X, Ye J, Hsueh E, Zhang Y, Hoft D, Peng G. Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J Immunol. 2010;184:1630-41 pubmed publisher
  31. Leffers N, Gooden M, de Jong R, Hoogeboom B, ten Hoor K, Hollema H, et al. Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer. Cancer Immunol Immunother. 2009;58:449-59 pubmed publisher
  32. Barnett J, Bean S, Whitaker R, Kondoh E, Baba T, Fujii S, et al. Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype. Gynecol Oncol. 2010;116:556-62 pubmed publisher
    ..The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s...
  33. Ruffell B, DeNardo D, Affara N, Coussens L. Lymphocytes in cancer development: polarization towards pro-tumor immunity. Cytokine Growth Factor Rev. 2010;21:3-10 pubmed publisher
    ..This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4(+) T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis...
  34. Houston A, Michael Robinson J, Walsh M, Cummings M, Ryan A, Lincoln D, et al. The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability. Hum Pathol. 2008;39:243-50 pubmed
    ..059). Together, these findings suggest that the abundance of TILs found in MSI-H tumors may be due to the failure of these tumor cells to up-regulate FasL and may explain, in part, the improved prognosis associated with these tumors...
  35. Ladoire S, Arnould L, Apetoh L, Coudert B, Martin F, Chauffert B, et al. Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res. 2008;14:2413-20 pubmed publisher
    ..To assess the capacity of neoadjuvant chemotherapy to affect T-cell infiltration in breast cancer, we evaluated CD3 and CD8 infiltrates, and the Foxp3 immunosuppressive T cells...
  36. Liakou C, Narayanan S, Ng Tang D, Logothetis C, Sharma P. Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human bladder cancer. Cancer Immun. 2007;7:10 pubmed
    ..b>Tumor infiltrating lymphocytes (TILs) have been observed in patients with melanoma, colon cancer, and ovarian cancer...
  37. Rudge G, Barrett S, Scott B, van Driel I. Infiltration of a mesothelioma by IFN-gamma-producing cells and tumor rejection after depletion of regulatory T cells. J Immunol. 2007;178:4089-96 pubmed
    ..Our data suggests that CD25+ T(reg) limit the accumulation of activated T cells producing IFN-gamma in the tumor tissue and, to a lesser extent, activation and/or rate of mitosis of tumor-specific T cells in lymph nodes...
  38. Cao X, Cai S, Fehniger T, Song J, Collins L, Piwnica Worms D, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity. 2007;27:635-46 pubmed
    ..Granzyme B and perforin are therefore relevant for Treg cell-mediated suppression of tumor clearance in vivo...
  39. Labarriere N, Gervois N, Bonnin A, Bouquié R, Jotereau F, Lang F. PBMC are as good a source of tumor-reactive T lymphocytes as TIL after selection by Melan-A/A2 multimer immunomagnetic sorting. Cancer Immunol Immunother. 2008;57:185-95 pubmed
    ..However, the conditions of peptide stimulation should be improved to prevent a possible loss of reactive clonotypes...
  40. Wu X, Zeng Y, Jin X, Kakehi Y. Enhanced susceptibility of adriamycin-treated human renal cell carcinoma cells to lysis by peripheral blood lymphocytes and tumor infiltrating lymphocytes. Oncol Rep. 2007;18:353-9 pubmed
    ..of human renal cell carcinoma (RCC) cells to lysis by peripheral blood lymphocytes (PBL) and tumor infiltrating lymphocytes (TIL)...
  41. Sasaki A, Tanaka F, Mimori K, Inoue H, Kai S, Shibata K, et al. Prognostic value of tumor-infiltrating FOXP3+ regulatory T cells in patients with hepatocellular carcinoma. Eur J Surg Oncol. 2008;34:173-9 pubmed
    ..To determine the prognostic value of tumor-infiltrating regulatory T cells (T(reg)), we conducted a retrospective study on 164 patients with hepatocellular carcinoma (HCC) who underwent curative hepatic resection...
  42. Fu J, Xu D, Liu Z, Shi M, Zhao P, Fu B, et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology. 2007;132:2328-39 pubmed
  43. Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H, et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res. 2007;13:2151-7 pubmed
    ..In this study, we tried to reveal the clinical importance and therapeutic potential of the PD-L/PD-1 pathway in pancreatic cancer, which is one of the most aggressive and intractable malignant tumors...
  44. Siddiqui S, Frigola X, Bonne Annee S, Mercader M, Kuntz S, Krambeck A, et al. Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma. Clin Cancer Res. 2007;13:2075-81 pubmed
    ..We tested for the presence of putative Tregs within renal cell carcinoma (RCC) tumors...
  45. Rajjoub S, Basha S, Einhorn E, Cohen M, Marvel D, Sewell D. Prognostic significance of tumor-infiltrating lymphocytes in oropharyngeal cancer. Ear Nose Throat J. 2007;86:506-11 pubmed
    ..We also found that the CD3high patients had higher rates of overall survival and disease-free survival at 3 and 5 years than did the CD3low patients; however; these differences only approached but did not reach statistical significance...
  46. Gjerdrum L, Woetmann A, Odum N, Burton C, Rossen K, Skovgaard G, et al. FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival. Leukemia. 2007;21:2512-8 pubmed
    ..In conclusion, our data indicate that the presence of FOXP3+ Tregs in CTCL is associated with disease stage and patient survival...
  47. Gao Q, Qiu S, Fan J, Zhou J, Wang X, Xiao Y, et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 2007;25:2586-93 pubmed
    ..To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection...
  48. Khammari A, Nguyen J, Pandolfino M, Quereux G, Brocard A, Bercegeay S, et al. Long-term follow-up of patients treated by adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma. Cancer Immunol Immunother. 2007;56:1853-60 pubmed
  49. Chen C, Lee H, Huang G, Yang P, Yu W, Cheng K, et al. Phenotypic analysis of tumor-infiltrating lymphocytes in hepatocellular carcinoma. Hepatogastroenterology. 2007;54:1529-33 pubmed
    ..Tumor may induce local immunosuppression and make the tumor-infiltrating lymphocytes (TILs) functionally inhibited and lose the antitumor effects. Therefore, we did the phenotypic analysis of TILs in hepatocellular carcinoma (HCC) tissues...
  50. Dunn G, Dunn I, Curry W. Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human glioma. Cancer Immun. 2007;7:12 pubmed
    ..e., antigen expression, how antigen may be presented, and lymphocyte trafficking--and subsequently discuss the extant work on TILs in glioma...
  51. Strauss L, Bergmann C, Szczepanski M, Gooding W, Johnson J, Whiteside T. A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin Cancer Res. 2007;13:4345-54 pubmed
    ..Tregs with a distinct phenotype in tumor-infiltrating lymphocytes (TIL) contribute to local immune suppression...
  52. Alaniz L, Rizzo M, Malvicini M, Jaunarena J, Avella D, Atorrasagasti C, et al. Low molecular weight hyaluronan inhibits colorectal carcinoma growth by decreasing tumor cell proliferation and stimulating immune response. Cancer Lett. 2009;278:9-16 pubmed publisher
    ..Besides, increased tumor infiltrating lymphocytes was observed in animals treated with LMW HA...
  53. Kirsch I, Vignali M, Robins H. T-cell receptor profiling in cancer. Mol Oncol. 2015;9:2063-70 pubmed publisher
    ..in lymphoid malignancies, the prediction of response to immunotherapeutics of solid tumors containing tumor infiltrating lymphocytes, the identification of clonal responses in vaccination, infectious disease, bone marrow reconstitution,..
  54. Deoti B, da Silva A, Costa M, Dinali A. Histological study of the left colon of rats after extra-mucosal seromyotomy (continent valves). Evaluation of colonic emptying. Acta Cir Bras. 2008;23:230-6 pubmed
    ..To elaborate an animal model with the objective of studying the continence of the biological valves surgically performed in the left colon of rats...
  55. Johnson L, Jameson S. Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation. J Immunol. 2010;184:5604-11 pubmed publisher
    ..Together, these data suggest that LIP does not always favor expansion of self-specific CD8 T cells and that sustained extensive lymphopenia is required for such cells to exhibit tumor control...