null lymphocytes

Summary

Summary: A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes.

Top Publications

  1. Sun Y, Fu A, Xu W, Chao J, Moshiach S, Morris S. Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3. J Physiol Biochem. 2015;71:807-21 pubmed publisher
    ..However, these effects were observed in Mlf1 null lymphocytes as well as the cells over-expressing Bcl-XL...
  2. Levelt C, Wang B, Ehrfeld A, Terhorst C, Eichmann K. Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur J Immunol. 1995;25:1257-61 pubmed
    ..These results suggest that the transition from TCR-beta to TCR-alpha locus rearrangement is controlled by signal transduction through the pre-TCR. ..
  3. Richter M, Taylor S, Macphail S, Jodouin C. Cells and mediators which participate in immunoglobulin synthesis by human mononuclear cells. II. The mechanism of null cell participation in immunoglobulin synthesis and secretion by B cells. Clin Exp Immunol. 1990;80:122-9 pubmed
  4. Rahal M, Reinish E, Osmond D. Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment. Cell Immunol. 1992;139:218-28 pubmed
    ..In each case, the number of null lymphocytes, as defined by a lack of radioautographic labeling of either B220 glycoprotein or Thy1, increased markedly in ..
  5. Melton E, Roux M. Detection of TdT-positive cells in the mesenteric lymph nodes of immunodeficient rats: study of their antigenic phenotype. Reg Immunol. 1989;2:408-13 pubmed
    ..Their origin may be attributed either to trafficking of immature cells from the thymus or to cells that leave the bone marrow as a consequence of the damage provoked by protein deprivation. ..
  6. Creager A, Geisinger K, Bergman S. Neutrophil-rich Ki-1-positive anaplastic large cell lymphoma: a study by fine-needle aspiration biopsy. Am J Clin Pathol. 2002;117:709-15 pubmed
    ..Reproducible cytologic features usually are present, and the diagnosis can be made conclusively by FNAB in conjunction with ancillary studies. ..
  7. Marrero Calvo M, Rodriguez Serna M, Castejón Calvete P, Peláez Malagón S. [Primary cutaneous anaplastic CD30+ large cell lymphoma]. Actas Dermosifiliogr. 2007;98:194-7 pubmed
    ..The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up. ..
  8. O Reilly K, Splitter G. Analysis of workshop antibodies to null cells on a non-T/non-B lymphocyte population. Vet Immunol Immunopathol. 1991;27:231-4 pubmed
    ..The enriched cells were principally CD5dim and contained greatly increased numbers of null lymphocytes. This methodology will be useful for null lymphocyte enrichment in examining cell surface molecules and ..
  9. Duncan I, Binns R, Duffus W. The null T cell in pig blood is not an NK cell. Immunology. 1989;68:392-5 pubmed
    ..Thus the resting Null T cell appears not to play a significant role in natural killing. ..

More Information

Publications85

  1. Gobin S, Legg R, Paine A, Phillips J. The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets in peripheral blood of the rat. Int J Immunopharmacol. 1989;11:937-46 pubmed
    ..The number of null cells (MARK-1-, OX-19-) was not affected; the majority of these cells appeared to be large granular lymphocytes. ..
  2. Yee H, Ponzoni M, Merson A, Goldstein M, Scarpa A, Chilosi M, et al. Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. Blood. 1996;87:1081-8 pubmed
    ..These findings show that some HD may be closely related to ALCL, giving us new insights on the pathogenesis and possibly biologic evolution of HD. ..
  3. Tongtawe P, Chaicumpa W, Tapchaisri P, Looareesuwan S, Webster H. Lymphocyte subpopulations during acute and convalescence phases of malaria. Asian Pac J Allergy Immunol. 1988;6:11-8 pubmed
    ..The finding might explain why the NK cell activity was low during the convalescence period. ..
  4. Prockop S, Petrie H. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J Immunol. 2004;173:1604-11 pubmed
    ..Together with asymmetric use of marrow-derived progenitors to reconstitute the intrathymic pool, these processes facilitate continuous generation of new T cells while maintaining a relatively stable organ size. ..
  5. Shimizu Y, DeMars R. Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line. J Immunol. 1989;142:3320-8 pubmed
    ..221 can be used to create human cells that express on their surfaces just one defined class I Ag encoded by a transferred class I gene. ..
  6. Kurosaki M, Saeger W, Lüdecke D. Pituitary tumors in the elderly. Pathol Res Pract. 2001;197:493-7 pubmed
    ..Our immunohistochemical study revealed that many tumors contained one or more than one anterior pituitary hormone, although almost all pituitary adenomas were considered to be clinically inactive in surgical and autopsy cases. ..
  7. Richter M, Jodouin C, Steele D. Cells and mediators involved in immunoglobulin synthesis by human circulating mononuclear cells. IV. B cells synthesize but do not secrete immunoglobulins because of a defect in the non-T non-B (null) cells. J Allergy Clin Immunol. 1992;90:301-12 pubmed
    ..The defect is in the null cell and not in the B cell and consists of the inability of the null cell to secrete HISFF that facilitates the synthesis and secretion of immunoglobulin by the B cell. ..
  8. Wallace V, Kawai K, Levelt C, Kishihara K, Molina T, Timms E, et al. T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur J Immunol. 1995;25:1312-8 pubmed
  9. Foss H, Demel G, Anagnostopoulos I, Araujo I, Hummel M, Stein H. Uniform expression of cytotoxic molecules in anaplastic large cell lymphoma of null/T cell phenotype and in cell lines derived from anaplastic large cell lymphoma. Pathobiology. 1997;65:83-90 pubmed
  10. Gava A, Moro L, De Angeli S, Coghetto F, Marazzato G, Fantin P, et al. [Effects of radiotherapy on lymphocyte populations in lung cancer]. Radiol Med. 1988;76:475-8 pubmed
  11. Howell C, Yoder T, Vierling J. Suppressor function of hepatic mononuclear inflammatory cells during murine chronic graft-vs-host disease. I. Macrophage-enriched cells mediate suppression in the liver. Cell Immunol. 1991;132:256-68 pubmed
    ..T cells contributed to the suppressor activity of both populations. However, the suppressor activity of hepatic MC was mediated largely by a macrophage-enriched population of MC while that of splenic MC was mediated largely by NS cells. ..
  12. Liu C, Muirhead K, George S, Landay A. Flow cytometric monitoring of human immunodeficiency virus-infected patients. Simultaneous enumeration of five lymphocyte subsets. Am J Clin Pathol. 1989;92:721-8 pubmed
  13. Sandberg K, Matsson P, Alm G. A distinct population of nonphagocytic and low level CD4+ null lymphocytes produce IFN-alpha after stimulation by herpes simplex virus-infected cells. J Immunol. 1990;145:1015-20 pubmed
    ..Another distinct population of infrequent but highly efficient IPC, tentatively designated natural IFN-alpha producing cells, is activated by stimuli such as HSV. ..
  14. Manohar V, Brown E, Chused T. Murine splenic null cell compartment contains distinct haemopoietic subpopulations: enlargement of a myeloid and an undifferentiated subset with the development of splenomegaly in New Zealand black mice. Immunology. 1992;75:448-55 pubmed
    ..The proportion of myeloid/erythroid null cells increases with age in NZB as splenomegaly develops. ..
  15. Binns R, Duncan I, Powis S, Hutchings A, Butcher G. Subsets of null and gamma delta T-cell receptor+ T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies. Immunology. 1992;77:219-27 pubmed
    ..Several properties of this new antigen complex specific to pig Null T cells show that it is distinct from the ruminant T19 complex...
  16. Starkey P, Sargent I, Redman C. Cell populations in human early pregnancy decidua: characterization and isolation of large granular lymphocytes by flow cytometry. Immunology. 1988;65:129-34 pubmed
    ..The possible role of decidual LGL in modulating placental development is discussed...
  17. Chisesi T, Vespignani M, Capnist G. Immunobeads test (antibody coated polyacrylamide beads) in the immunological characterization of lymphoproliferative disorders. Int J Biol Markers. 1987;2:173-6 pubmed
    ..The different findings were related to the number of DM cells (ER+, SIg+ QT+) and the different tests used. The importance of these findings in the diagnostic approach to lymphoproliferative disorders is discussed...
  18. Davidson W, Roths J, Holmes K, Rudikoff E, Morse H. Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol. 1984;133:1048-56 pubmed
    ..This suggests that factors other than defective IL 2 production and polyclonal B cell activation are required for the development of fulminant autoimmune disease...
  19. Fasth A, Snir O, Johansson A, Nordmark B, Rahbar A, af Klint E, et al. Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis. Arthritis Res Ther. 2007;9:R87 pubmed
    ..Together these data imply a primary role for CD4+CD28null T cells in manifestations elsewhere than in the joints of patients with HCMV-seropositive rheumatoid arthritis...
  20. Hayashi T, Utoh H, Nonaka Y, Suzuki T, Nomura T, Sasajima Y, et al. [Null-cell non-Hodgkin's lymphoma presenting with a mass in the chest wall after tuberculous pyothorax]. Rinsho Ketsueki. 1993;34:1562-7 pubmed
    ..Approximately 100 cases of non-Hodgkin's lymphoma developing after tuberculous pyothorax have been reported in this country, among which the incidence of null cell type is exceedingly rare...
  21. Snabboon T, Plengpanich W, Siriwong S, Wisedopas N, Suwanwalaikorn S, Khovidhunkit W, et al. A novel germline mutation, 1793delG, of the MEN1 gene underlying multiple endocrine neoplasia type 1. Jpn J Clin Oncol. 2005;35:280-2 pubmed
    ..This mutation is predicted to cause a loss of the second nuclear localization signal of the menin protein...
  22. McSheehy P, Gervasoni M, Lampasona V, Erba E, D INCALCI M. Studies of the differentiation properties of camptothecin in the human leukaemic cells K562. Eur J Cancer. 1991;27:1406-11 pubmed
    ..Camptothecin induction of differentiation and inhibition of proliferation may occur by independent mechanisms...
  23. Jirillo A, Balli M, Disperati A, Capuzzo E, Chiavolini P, Lonardi F. [Peripheral lymphocyte populations in patients treated with pelvic and mediastinal radiotherapy]. Radiol Med. 1989;78:448-51 pubmed
    ..Thus any significant correlation between immunological state and disease evolution or response to treatment has still to be verified...
  24. Geboes K, Abu El Asrar A, Missotten L. Immune cells in a case of postherpetic marginal trophic ulcer. Br J Ophthalmol. 1989;73:191-6 pubmed
    ..The composition of the infiltrate points towards the involvement of cell mediated immunity as well as humoral immunity. No immunoglobulins were bound to the conjunctival epithelium...
  25. Gotoh M, Kitahara T, Iguchi T, Izumi M, Mukai K, Ohyashiki K. [HIV-related multiple non-Hodgkin lymphomas]. Rinsho Ketsueki. 2008;49:1552-5 pubmed
    ..This case suggested that cancer generation was promoted by low immunity, although it is known that ambivalent tumors such as non-Hodgkin lymphomas can occur frequently...
  26. Liao H, de Los Santos J, Carpenter G. Contrasting role of phospholipase C-gamma1 in the expression of immediate early genes induced by epidermal or platelet-derived growth factors. Exp Cell Res. 2006;312:807-16 pubmed
    ..Electrophoretic mobility shift assays (EMSA) demonstrate that PLC-gamma1 is necessary for nuclear extracts from PDGF-treated cells, but not EGF-treated cells, to interact with probes for AP-1 or NF-kappaB...
  27. Laws E, Lopes M. The new WHO classification of pituitary tumors: highlights and areas of controversy. Acta Neuropathol. 2006;111:80-1 pubmed
  28. Günzl H, Saeger W, Diehl S, Lüdecke D. Immunohistochemical analyses of oncocytic and chromophobe pituitary adenomas. Exp Clin Endocrinol. 1988;92:51-8 pubmed
    ..In most cases, the studied oncocytomas did not react to synaptophysin showing different results from other adenomas of the anterior hypophysis...
  29. Taylor S, Jodouin C, Richter M. Cells and mediators which participate in immunoglobulin synthesis by human mononuclear cells. III. Null cells secrete a factor(s) (human immunoglobulin synthesis/secretion-facilitating factor) that can replace the null cells in the synthesis of immun. Clin Exp Immunol. 1990;80:130-5 pubmed
  30. Auerbach L, Hafner T, Huber J, Panzer S. Influence of low-dose oral contraception on peripheral blood lymphocyte subsets at particular phases of the hormonal cycle. Fertil Steril. 2002;78:83-9 pubmed
    ..To investigate the effects of low-dose oral hormonal contraception on the immune system during certain phases of the hormonal cycle...
  31. Manzanal A, Santon A, Acevedo A, Aguilera B, Oliva H, Bellas C. Molecular analysis of the IgH gene in 212 cases of Hodgkin's disease: correlation of IgH clonality with the histologic and the immunocytochemical features. Mod Pathol. 1997;10:679-85 pubmed
    ..There was, however, no correlation between the histologic subtype, the percentage of HRS cells, the presence of latent membrane protein-1 expression, and the molecular analysis results...
  32. Maes B, Anastasopoulou A, Kluin Nelemans J, Teodorovic I, Achten R, Carbone A, et al. Among diffuse large B-cell lymphomas, T-cell-rich/histiocyte-rich BCL and CD30+ anaplastic B-cell subtypes exhibit distinct clinical features. Ann Oncol. 2001;12:853-8 pubmed
    ..Established in 1994, the R.E.A.L. Classification on NHL has now replaced all former classifications...
  33. Tice D, Davey F. The T-lymphocyte colony-forming cell (T-CFC): in vitro studies of progenitors and progeny. Clin Exp Immunol. 1988;72:243-8 pubmed
    ..Plating of CD4+ or CD8+ cells produced both CD4+ and CD8+ colonies. We conclude that T-CFC exist in the CD4+, CD8+ and null-cell populations. In addition, T-CFC give rise to T-cell colonies possessing either CD4+ or CD8+ determinants...
  34. Hoff H, Knieke K, Cabail Z, Hirseland H, Vratsanos G, Burmester G, et al. Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells. J Immunol. 2009;182:5342-51 pubmed publisher
    ..Our data imply strongly that antagonistic approaches using CD152 signals for chronic immune responses might be beneficial...
  35. Katz F, Malcolm S, Gibbons B, Tilly R, Lam G, Robertson M, et al. Cellular and molecular studies on infant null acute lymphoblastic leukemia. Blood. 1988;71:1438-47 pubmed
  36. Komori T, Sugiyama H, Kishimoto S. A novel VHDJH to JH joining that induces H chain production in an Ig-null immature B cell line. J Immunol. 1989;143:1040-5 pubmed
    ..This sequence might be a novel recombination signal sequence, which had not yet been reported, for so-called recombinase...
  37. Weisenburger D, Anderson J, Diebold J, Gascoyne R, Maclennan K, Muller Hermelink H, et al. Systemic anaplastic large-cell lymphoma: results from the non-Hodgkin's lymphoma classification project. Am J Hematol. 2001;67:172-8 pubmed
    ..In contrast, patients with ALCL-B appear to be similar to those with other forms of DLBCL...
  38. Hu J, Song H, Wang X, Shen Y, Chen F, Liu Y, et al. Gene expression profiling in human null cell pituitary adenoma tissue. Pituitary. 2007;10:47-52 pubmed
    ..All of these data may contribute to the understanding of null cell adenoma formation and development...
  39. Sharaf M. [Basaliom. Case report and isolation of mesenchymal stroma cells in various growth conditions in vitro]. Dtsch Z Mund Kiefer Gesichtschir. 1991;15:170-7 pubmed
    ..The culture of tumor tissue cells in different media thus seems to enhance the dominance of different cell subtypes...
  40. Liuzzo G, Biasucci L, Trotta G, Brugaletta S, Pinnelli M, Digianuario G, et al. Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events. J Am Coll Cardiol. 2007;50:1450-8 pubmed
    ..We hypothesized that the expansion of unusual T lymphocytes, CD4+CD28null T cells, might represent a key pathogenetic mechanism of recurrent instability...
  41. Belden E, Peng H. Bovine antibody dependent cell-mediated cytotoxicity (ADCC) effector cells. Vet Immunol Immunopathol. 1987;16:157-71 pubmed
    ..Each enriched cell population, peripheral blood mononuclear cells (PBM), null lymphocytes, monocytes and neutrophils, was then examined for its capacity to mediate ADCC...
  42. Cuddihy A, Ge S, Zhu J, Jang J, Chidgey A, Thurston G, et al. VEGF-mediated cross-talk within the neonatal murine thymus. Blood. 2009;113:2723-31 pubmed publisher
    ..These data demonstrate that, during the early postnatal period, VEGF mediates cross-talk between the thymocyte and endothelial compartments of the thymus...
  43. Yang T, Mather J, Rabinovsky E. Changes in subpopulations of lymphocytes in peripheral blood, and supramammary and prescapular lymph nodes of cows with mastitis and normal cows. Vet Immunol Immunopathol. 1988;18:279-85 pubmed
    ..47 +/- 1.28 X 10(6) cells/ml). In the prescapular lymph node the percent of B lymphocytes, but not T or "null lymphocytes", decreased significantly in mastitic cows as compared to that of normals. The decrease, i.e...
  44. Binns R, Bischof R, Carr M, Davis W, Licence S, Misfeldt M, et al. Report on the behaviour of monoclonal antibodies in the First International Pig CD Workshop identifying the Null cell families. Vet Immunol Immunopathol. 1994;43:279-87 pubmed
  45. Iwasaki T, Hamano T, Aizawa K, Kobayashi K, Kakishita E. Characterization of a functional null cell line derived from NZB x NZW)F1 mice. Scand J Immunol. 1994;40:669-74 pubmed
  46. Aoki I, Kinzer C, Shirai A, Paul W, Klinman D. IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice. Proc Natl Acad Sci U S A. 1995;92:2534-8 pubmed
  47. Nagasaki M, Morikawa S, Harada T, Miyasaka N. A novel EBV-related nucleo-cytoplasmic antigen in a null cell-line (HLN-STL-C) reactive to antibodies in the sera from patients with Sjögren's syndrome. J Autoimmun. 1989;2:457-62 pubmed
    ..These results suggested the presence of heterogenous components in the N-C antigen. Our findings may support the hypothetical conception that EBV plays an etiological role in SS...
  48. Le Gros G, Ben Sasson S, Conrad D, Clark Lewis I, Finkelman F, Plaut M, et al. IL-3 promotes production of IL-4 by splenic non-B, non-T cells in response to Fc receptor cross-linkage. J Immunol. 1990;145:2500-6 pubmed
  49. Voorter C, Lardy N, van den Berg Loonen E. Presence of the DRB4*0103102N null allele in different DRB1*04-positive individuals. Tissue Antigens. 2000;55:37-43 pubmed
    ..Identification of DR4-positive DR53-negative individuals as described here, provided the serological reactions with DR53-antisera and revealed the antibody specificities in the antisera used...
  50. Davis W, Zuckermann F, Hamilton M, Barbosa J, Saalmuller A, Binns R, et al. Analysis of monoclonal antibodies that recognize gamma delta T/null cells. Vet Immunol Immunopathol. 1998;60:305-16 pubmed
    ..Three mAbs did not form clusters. Three mAbs predicted to recognize TcR in the first workshop (020 [PT14A], 021 [PT79A], and 022 [MUC127A]) and mAb PGBL22A were shown to immunoprecipitate a 37, 40 kDa heterodimer...
  51. Mackay C, Marston W, Dudler L, Hein W. Expression of the "T19" and "null cell" markers on gamma delta T cells of the sheep. Vet Immunol Immunopathol. 1991;27:183-8 pubmed
    ..This probably results from differential expression of certain epitopes on T19. The reactivity of most of the mAbs for the 215 kDa T19 molecule was also confirmed by immunoprecipitation and SDS-PAGE...
  52. Conrad D, Ben Sasson S, Le Gros G, Finkelman F, Paul W. Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J Exp Med. 1990;171:1497-508 pubmed
  53. Hironaka T, Nagasaki M, Morikawa S, Hirai K. Detection of Epstein-Barr virus transcripts in chemically or immunologically-activated cells and in a null cell-line (HLN-STL-C) by in situ hybridization with alkaline phosphatase-linked oligonucleotide probes. J Virol Methods. 1993;44:141-54 pubmed
    ..1% of the cells contained gp350/220 mRNA, indicating that a few of the null cells which carried the EBV genome spontaneously entered the late EBV replication cycle...
  54. Licence S, Davis W, Carr M, Binns R. The behaviour of monoclonal antibodies in the First International Pig CD Workshop reacting with gamma delta/Null T lymphocytes in the blood of SLAb/b line pigs. Vet Immunol Immunopathol. 1995;47:253-71 pubmed
    ..Based on these data we suggest a putative relationship of the Null cell subsets defined by these mAbs with each other...
  55. Hammerberg C, Dillon Long P, Melendez L, Pyle R, Ochs D. Isolation of an antigenically "null" cell line from pig peripheral blood mononuclear cells. Vet Immunol Immunopathol. 1988;18:317-30 pubmed
    ..An association of viral particles with cells of the A4 morphology and null antigenic characteristics was observed and may provide an explanation for the reduced B cell properties of A4 cells...
  56. Lloyd R, Anagnostou D, Chandler W. Dopamine receptors in immunohistochemically characterized null cell adenomas and normal human pituitaries. Mod Pathol. 1988;1:51-6 pubmed
    ..These results indicate that immunohistochemically characterized null cell adenomas as well as normal pituitaries express dopamine receptors, but that the binding sites in null cell adenomas are much less those in PRL-secreting adenomas...
  57. Guerrero R, Navarro P, Gallego E, Avila J, de Yebenes J, Sanchez M. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. J Alzheimers Dis. 2008;13:161-72 pubmed
    ..Thus, the combination of Park-2 gene deletion with hTauVLW transgene overexpression in mice produces serious neuropathological effects, which reflect the existence of some relationship between both proteins...
  58. Ambrosino E, Berzofsky J, Terabe M. Regulation of tumor immunity: the role of NKT cells. Expert Opin Biol Ther. 2008;8:725-34 pubmed
    ..Recent studies suggest that NKT cells are a heterogeneous cell population with multiple subsets with distinct functions...
  59. Sano T. Comments on the WHO histological classification of pituitary tumors. Acta Neuropathol. 2006;111:82-3 pubmed
  60. Binns R, Pabst R, Licence S. Subpopulations of T lymphocytes emigrating in venous blood draining pig thymus labelled in vivo with fluorochrome. Immunology. 1988;63:261-7 pubmed
    ..The large population of thymus-dependent Null lymphocytes in young pig blood apparently arise in thymus since they constitute 1/3 of emigrants, although only forming ..
  61. Ressel M, Kohler G, Straube W. [Behavior of T-lymphocytes during the normal menstrual cycle]. Zentralbl Gynakol. 1988;110:619-22 pubmed
    ..If there is a causative connection and whether the whole immune system is depressed or other regulatory mechanisms interfere isn't quite clear...
  62. Buurman H, Saeger W. Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data. Eur J Endocrinol. 2006;154:753-8 pubmed
  63. Tomino Y, Ohmuro H, Kuramoto T, Shirato I, Eguchi K, Sakai H, et al. Expression of intercellular adhesion molecule-1 and infiltration of lymphocytes in glomeruli of patients with IgA nephropathy. Nephron. 1994;67:302-7 pubmed
    ..However, the expression of ICAM-1 in glomeruli might not be correlated with IgA-dominant immune complexes in this disease...
  64. Fukui Y, Engler S, Inoue S, de Hostos E. Architectural dynamics and gene replacement of coronin suggest its role in cytokinesis. Cell Motil Cytoskeleton. 1999;42:204-17 pubmed
    ..Overall, this study suggests that coronin is essential for organizing the normal actin cytoskeleton and plays a significant role in cell division...
  65. Binns R. The Null/gamma delta TCR+ T cell family in the pig. Vet Immunol Immunopathol. 1994;43:69-77 pubmed
    ..Elucidation of the roles of these enigmatic cells and their characteristic surface macromolecules in the initiation and regulation of immune functions promises to reveal much of fascination...
  66. Bloom E, Babbitt J. Role of cytokines in the monocyte-mediated augmentation of human natural killer cell activity. Cell Immunol. 1987;109:123-38 pubmed
    ..These results provide the first evidence for a cellular, and potentially physiologic, basis for the regulation of NK activity by IL-1 and IL-2, which had been previously known to act at pharmacologic levels in vitro...
  67. Helmby H, Kullberg M, Troye Blomberg M. Expansion of IL-3-responsive IL-4-producing non-B non-T cells correlates with anemia and IL-3 production in mice infected with blood-stage Plasmodium chabaudi malaria. Eur J Immunol. 1998;28:2559-70 pubmed
    ..Thus, IL-3-responsive IL-4-producing NBNT cells may provide cytokines supporting the switch from Th1 to a Th2 response which is important for the final clearance of the parasite in P. chabaudi malaria...
  68. Bang Y, Nguyen T, Trinh T, Kim Y, Song J, Song Y. Functional analysis of mutations in UDP-galactose-4-epimerase (GALE) associated with galactosemia in Korean patients using mammalian GALE-null cells. FEBS J. 2009;276:1952-61 pubmed publisher
    ..Our observations show that altered protein stability is due to misfolding and that loss or reduction of enzyme activity is responsible for the molecular defects underlying GALE-deficiency galactosemia...
  69. Asano N, Suzuki R, Matsuo K, Kagami Y, Ishida F, Tamaru J, et al. Cytotoxic molecule expression is predictive of prognosis in Hodgkin's-like anaplastic large cell lymphoma. Histopathology. 2007;50:705-15 pubmed
    ..The aim of this study was to clarify the association between cytotoxic molecule (CM) expression and clinical outcome in HD-like ALCL...
  70. Sopp P, Howard C, Parsons K. Investigating monoclonal antibodies to bovine "null" cell antigens using two-colour immunofluorescence. Vet Immunol Immunopathol. 1991;27:163-8 pubmed
  71. Richter M, Kamran M, Jodouin C. Surface receptors and immune activity of purified human circulating mononuclear cells. V. Circulating null cells and a factor secreted by the null cells inhibit the synthesis of receptors for Fc mu by T cells in culture. Eur J Immunol. 1990;20:803-7 pubmed
  72. Sobel E, Kakkanaiah V, Kakkanaiah M, Cohen P, Eisenberg R. Co-infusion of normal bone marrow partially corrects the gld T-cell defect. Evidence for an intrinsic and extrinsic role for Fas ligand. J Immunol. 1995;154:459-64 pubmed
    ..Surprisingly, the residual CD4-CD8- T cells present in the mixed chimeras were derived entirely from the gld donor marrow. This suggests that the gld mutation results in both an extrinsic and intrinsic defect in T cells...
  73. d Amore E, Menin A, Bonoldi E, Bevilacqua P, Cazzavillan S, Donofrio V, et al. Anaplastic large cell lymphomas: a study of 75 pediatric patients. Pediatr Dev Pathol. 2007;10:181-91 pubmed
    ..Clusterin, CD83, and Pax5, respectively, expressed in 91.3%, 1.7%, and 0% of the ALCLs, were useful biomarkers for the differential diagnosis with Hodgkin's lymphomas...
  74. Foss H, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer J, et al. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood. 1996;88:4005-11 pubmed
  75. Baldwin C, Black S, Brown W, Conrad P, Goddeeris B, Kinuthia S, et al. Bovine T cells, B cells, and null cells are transformed by the protozoan parasite Theileria parva. Infect Immun. 1988;56:462-7 pubmed
    ..Further studies on cell lines and clones grown in vitro from populations isolated from T. parva-infected cattle suggested that the majority of the in vivo T. parva-transformed cells were of T-cell origin...
  76. Furuhata S, Kameya T, Tsuruta T, Naritaka H. Clinical and ultrastructural comparison of immunohistochemically inactive and gonadotropin-producing pituitary adenomas. Neurol Med Chir (Tokyo). 1995;35:227-30 pubmed
    ..The immunohistochemically unstable antigenicity of gonadotropin prevents clear immunohistochemical characterization, but the difference between the two types is not absolute and may be an indication of a cell line relationship...