granulocyte precursor cells


Summary: The cells in the granulocytic series that give rise to mature granulocytes (NEUTROPHILS; EOSINOPHILS; and BASOPHILS). These precursor cells include myeloblasts, promyelocytes, myelocytes and metamyelocytes.

Top Publications

  1. Bae S, Ryoo H, Cho H, Lee J, Lee K, Hyun M. Meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature. J Korean Med Sci. 2004;19:311-4 pubmed
    ..The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy...
  2. De La Fuente J, Ayoubi P, Blouin E, Almazan C, Naranjo V, Kocan K. Gene expression profiling of human promyelocytic cells in response to infection with Anaplasma phagocytophilum. Cell Microbiol. 2005;7:549-59 pubmed
    ..phagocytophilum-infected HL-60 cells, thus expanding in a global manner the existing information on the response of mammalian cells to A. phagocytophilum infection...
  3. Brugnoli F, Bavelloni A, Benedusi M, Capitani S, Bertagnolo V. PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. Cell Signal. 2007;19:1701-12 pubmed
  4. Ressel A, Trumper L, Basecke J. [Occlusion of the femoral arteries in de novo AML]. Med Klin (Munich). 2007;102:388-92 pubmed
    ..Therapeutic options, apart from the immediate start of chemotherapy, are leukapheresis and embolectomy. ..
  5. Aldinucci D, Cattaruzza L, Lorenzon D, Giovagnini L, Fregona D, Colombatti A. Antiproliferative and apoptotic effects of two new Pd(II) methylsarcosinedithiocarbamate derivatives on human acute myeloid leukemia cells in vitro. Oncol Res. 2008;17:103-13 pubmed
  6. Albright E, Kalejta R. Myeloblastic cell lines mimic some but not all aspects of human cytomegalovirus experimental latency defined in primary CD34+ cell populations. J Virol. 2013;87:9802-12 pubmed publisher
    ..Aspects of latency illuminated through the use of these myeloblastoid cell lines should not be considered independently but integrated with results obtained in primary cell systems when paradigms for HCMV latency are proposed. ..
  7. Zimecki M, Artym J, Kocieba M, Weber Dabrowska B, Borysowski J, Gorski A. Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus. BMC Microbiol. 2009;9:169 pubmed publisher
    ..aureus. Application of specific phages to immunosuppressed mice prior to infection with S. aureus proved very effective, suggesting a potential benefit of phage therapy in immunocompromised patients experiencing bacterial infections. ..
  8. Marstrand T, Borup R, Willer A, Borregaard N, Sandelin A, Porse B, et al. A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia. Leukemia. 2010;24:1265-75 pubmed publisher
  9. Oka S, Muroi K, Matsuyama T, Sato K, Ueda M, Toshima M, et al. Correlation between flow cytometric identification of CD33-positive cells and morphological evaluation of myeloblasts in bone marrow of patients with acute myeloblastic leukemia. Hematology. 2009;14:133-8 pubmed publisher
    ..672, p<0.001). The identification of CD33+ cells by FCM/CD45 is useful for the evaluation of bone marrow myeloblasts in AML. ..

More Information

Publications110 found, 100 shown here

  1. Rosen H, Calafat J, Holmberg L, Olsson I. Sorting of Von Willebrand factor to lysosome-related granules of haematopoietic cells. Biochem Biophys Res Commun. 2004;315:671-8 pubmed
  2. Font P, Subira D, Mtnez Chamorro C, Castañón S, Arranz E, Ramiro S, et al. Evaluation of CD7 and terminal deoxynucleotidyl transferase (TdT) expression in CD34+ myeloblasts from patients with myelodysplastic syndrome. Leuk Res. 2006;30:957-63 pubmed
    ..Therefore, CD7 and TdT may help to establish the diagnosis of MDS and, TdT expression also seems to be a useful marker in distinguishing risk groups. ..
  3. Becker P, Kopecky K, Wilks A, Chien S, Harlan J, Willman C, et al. Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia. Blood. 2009;113:866-74 pubmed publisher
    ..Adhesion and migratory properties of AML blasts thus appear to influence chemosensitivity and therefore may be therapeutic targets. ..
  4. Bertagnolo V, Grassilli S, Petretto A, Lambertini E, Astati L, Bruschi M, et al. Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytes. J Proteomics. 2011;75:398-409 pubmed publisher
    ..Since defects in mRNA processing are common in tumor development, our data suggest that Vav1 is a potential target molecule for developing new anti-cancer strategies. ..
  5. Fathi A, Sadrzadeh H, Borger D, Ballen K, Amrein P, Attar E, et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. Blood. 2012;120:4649-52 pubmed publisher
    ..2-HG decrease was more rapid with induction chemotherapy compared with DNA-methyltransferase inhibitor therapy. Our data suggest that serum or urine 2-HG may serve as noninvasive biomarkers of disease activity for IDH-mutant AML. ..
  6. Mazzella F, Smith D, Horn P, Cotelingam J, Rector J, Shrit M, et al. Prognostic significance of pronormoblasts in erythrocyte predominant myelodysplastic patients. Am J Hematol. 2006;81:484-91 pubmed
    ..Of these, % pronormoblasts was by far the most significant. Nonappearance of % myeloblasts in this model is indicative of high correlations of this count with other variables. ..
  7. Careccia S, Mainardi S, Pelosi A, Gurtner A, Diverio D, Riccioni R, et al. A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes. Oncogene. 2009;28:4034-40 pubmed publisher
    ..In conclusion, we show that a small subset of miRNAs is differentially expressed in APL and modulated by ATRA-based treatment. ..
  8. Chhabra S, Kumar Y, Thacker G, Kapoor I, Lochab S, Sanyal S, et al. E6AP inhibits G-CSFR turnover and functions by promoting its ubiquitin-dependent proteasome degradation. Biochim Biophys Acta Mol Cell Res. 2017;1864:1545-1553 pubmed publisher
    ..G-CSFR) plays a crucial role in regulating myeloid cell survival, proliferation, and neutrophilic granulocyte precursor cells maturation...
  9. Mar J, Quackenbush J. Decomposition of gene expression state space trajectories. PLoS Comput Biol. 2009;5:e1000626 pubmed publisher
    ..Using functional enrichment analyses, specific biological examples and an analysis of the trajectories and their core and transient components we provide a validation of our hypothesis using the Huang et al. (2005) dataset. ..
  10. Yashiki C, Hirose T, Sugiyama T, Kusumoto S, Shirai T, Ohmori T, et al. [Chemotherapy-induced myelosuppression and treatment efficacy in limited-stage disease small cell lung cancer]. Gan To Kagaku Ryoho. 2010;37:245-9 pubmed
    ..There were no independent prognostic factors for TTP. Myelosuppression during chemotherapy is not a prognostic factor in LD SCLC. Our results show doses of platinum doublet chemotherapy were adequate in patients with LD SCLC. ..
  11. Hamahata K, Kotani S, Oka S, Ukyo N, Watanabe N, Nogawa M. Development of donor cell leukemia mimicking hematogones after unrelated cord blood transplantation for relapsed acute lymphoblastic leukemia. Rinsho Ketsueki. 2013;54:473-7 pubmed
  12. Hashiramoto A, Konishi Y, Murayama K, Kawasaki H, Yoshida K, Tsumiyama K, et al. A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell. J Biol Chem. 2018;293:1933-1943 pubmed publisher
    ..In summary, our results reveal that a DR3 splice variant that interferes with ligand-induced T cell responses and apoptosis may contribute to RA pathogenesis. ..
  13. Barrios L, Poletti O. Effects of filgrastim on granulopoietic cells of mice pretreated with methotrexate. Biocell. 2005;29:7-14 pubmed
    ..They can be also explained in terms of an unfavorable marrow microenvironment for granulopoiesis, contrary to a supportive spleen microenvironment. ..
  14. Goldberg E, Dygai A, Zyuz kov G. Role of Thy-1,2+ cells in the regulation of hemopoiesis during severe hypoxia. Bull Exp Biol Med. 2007;143:18-21 pubmed
  15. Masubuchi N, May R, Atsumi R. A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay. Clin Cancer Res. 2004;10:6722-31 pubmed
    ..The application of this model for in vitro hematotoxicology could play an important role for the development of new anticancer agents. ..
  16. Soh B, Klein F, Feldhahn N, MUSCHEN M. B-lymphoid or myeloid lineage identity of cell lines derived from chronic myeloid leukemia blast crisis. Cancer Genet Cytogenet. 2005;161:187-8 pubmed
  17. Smetana K, Klamova H, Mikulenkova D, Pluskalova M, Hrkal Z. On the nucleolar size and density in human early granulocytic progenitors, myeloblasts. Eur J Histochem. 2006;50:119-24 pubmed
    ..In addition, karyometry combined with RNA cytochemistry still appears to be an useful tool to study nucleoli at the single cell level. ..
  18. Cheung A, Chow H, Liang R, Leung A. A comparative study of bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia. Br J Haematol. 2009;144:484-91 pubmed publisher
    ..These data suggested that circulating primitive myeloblasts in AML are functionally different from those residing in the marrow compartment, and such differences may be partly regulated by the BM microenvironment. ..
  19. Katzenback B, Belosevic M. Characterization of granulocyte colony stimulating factor receptor of the goldfish (Carassius auratus L.). Dev Comp Immunol. 2012;36:199-207 pubmed publisher
    ..Furthermore, gcsfr mRNA levels were up-regulated in neutrophils after treatment with heat-killed Aeromonas salmonicida A449 or with mitogens. Our results indicate that GCSFR may be a useful marker for fish neutrophils. ..
  20. Astashkin E, Til kunova N, Zalepugin D, Grachev S. Diallyl sulfide depletes the inositol trisphosphate-sensitive intracellular Ca2+ stores and activates SOC-channels in HL-60 human cells. Dokl Biol Sci. 2004;399:500-2 pubmed
  21. Huang S, Guo Y, May G, Enver T. Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev Biol. 2007;305:695-713 pubmed
  22. Yu H, Lee Y, Noh E, Lee K, Song E, Han M, et al. Tumor necrosis factor-alpha enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway. Int J Hematol. 2008;87:189-194 pubmed publisher
    ..These results suggest that TNF-alpha synergistically increases DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK-signaling pathway. ..
  23. Vega F, Medeiros L, Davuluri R, Cromwell C, Alkan S, Abruzzo L. t(8;13)-positive bilineal lymphomas: report of 6 cases. Am J Surg Pathol. 2008;32:14-20 pubmed
    ..They likely arise from an early hematopoietic cell with potential to differentiate along T-cell and myeloid pathways. ..
  24. Yang M, Büsche G, Ganser A, Li Z. Morphology and quantitative composition of hematopoietic cells in murine bone marrow and spleen of healthy subjects. Ann Hematol. 2013;92:587-94 pubmed publisher
  25. Roth C, Garner K, Eyck S, Boyiadzis M, Kane L, Craig F. TIM3 expression by leukemic and non-leukemic myeloblasts. Cytometry B Clin Cytom. 2013;84:167-72 pubmed publisher
    ..This overlap limits the diagnostic utility of TIM3 as a specific marker of neoplasia. ..
  26. Duque Afonso J, Smith K, Cleary M. Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice. PLoS ONE. 2015;10:e0143216 pubmed publisher
    ..In conclusion, we have developed conditional E2A-HLF knock-in mice, which provide an experimental platform to study cooperating genetic events and further elucidate translational biology in cross-species comparative studies. ..
  27. Rossetti S, VAN Unen L, Touw I, Hoogeveen A, Sacchi N. Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulation. Oncogene. 2005;24:5325-32 pubmed
    ..Thus, there seems to be an association between AML1-MTG16-induced myeloid maturation block and epigenetic changes of a myeloid master gene. ..
  28. Hsiao P, Kuo S, Chen J, Lin H, Chu P, Lin S, et al. Acute myelogenous leukemia and acute leukemic appendicitis: a case report. World J Gastroenterol. 2009;15:5624-5 pubmed
    ..Although leukemic cell infiltration of the appendix is uncommon, patients with leukemia relapse can present with symptoms mimicking acute appendicitis. ..
  29. Moravkova A, Malek O, Pokorna E, Strnádel J, Hradecky J, Horak V. Immune characterization of the Lewis rats inoculated with K2 sarcoma cell line and newly derived R5-28 malignant cells. Folia Biol (Praha). 2005;51:159-65 pubmed
    ..Leukocytosis with highly increased numbers of CD11b+ myeloid cells displaying variable expression of CD4 was detected in terminal stages of the disease. ..
  30. Paredes Gamero E, Dreyfuss J, Nader H, Miyamoto Oshiro M, Ferreira A. P2X7-induced apoptosis decreases by aging in mice myeloblasts. Exp Gerontol. 2007;42:320-6 pubmed
    ..Furthermore, P2X(7) expression decrease was observed in older mice, explaining apoptosis decrease. This decrease in apoptosis by aging may be related to some diseases in the myelocyte lineage. ..
  31. Skurikhin E, Pershina O, Minakova M, Dygai A, Gol dberg E. Monoaminergic regulation of proliferation and differentiation of granulomonocytopoietic precursors during neuroses. Bull Exp Biol Med. 2006;141:669-74 pubmed
  32. Bugl S, Wirths S, Radsak M, Schild H, Stein P, André M, et al. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood. 2013;121:723-33 pubmed publisher
    ..Steady-state and emergency granulopoiesis are both dependent on TLR signaling. ..
  33. Batova A, Cottam H, Yu J, Diccianni M, Carrera C, Yu A. EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Blood. 2006;107:898-903 pubmed
    ..Collectively, these data indicate that EFA is an effective agent for salvaging MTAP+ cells from L-alanosine toxicity and is superior to MTA due to lower cytotoxicity. ..
  34. Lee J, Lim K. Normalizing effect of plant-originated glycoprotein (116 kDa) on G0/G1 arrest in cadmium chloride-induced primary cultured mouse myelocytes. Naunyn Schmiedebergs Arch Pharmacol. 2011;383:109-18 pubmed publisher
    ..Thus, UDN glycoprotein appears to be one compound derived from natural products that is able normalize the calcium chloride-mediated arrest of cell cycle (G(0)/G(1)) in immune cells. ..
  35. Zhu H, Liu Y, Jiang H, Lu J, Qin Y, Jiang Q, et al. CD34 expression on bone marrow blasts is a novel predictor of poor prognosis independent of FlT3-ITD in acute myeloid leukemia with the NPM1-mutation. Leuk Res. 2013;37:624-30 pubmed publisher
  36. Yang H, Acker J, Cabuhat M, Letcher B, Larratt L, McGann L. Association of post-thaw viable CD34+ cells and CFU-GM with time to hematopoietic engraftment. Bone Marrow Transplant. 2005;35:881-7 pubmed
    ..Therefore, the post-cryopreservation number of viable CD34(+) cells or CFU-GM should be used to eliminate the risks of unforeseen cell loss that could occur during cryopreservation or long-term storage. ..
  37. Schiffer C. Advances in MDS. Clin Adv Hematol Oncol. 2007;5:450-2 pubmed
  38. Sharawat S, Gupta R, Raina V, Kumar L, Sharma A, Iqbal S, et al. Increased coexpression of c-KIT and FLT3 receptors on myeloblasts: independent predictor of poor outcome in pediatric acute myeloid leukemia. Cytometry B Clin Cytom. 2013;84:390-7 pubmed publisher
    ..25). This is the first study to show that high coexpression of CD135+CD117 is an independent predictor of poor outcome in AML and is easily measurable by routine diagnostic flow-cytometry. ..
  39. Auewarakul C, Promsuwicha O, U pratya Y, Pattanapanyasat K, Issaragrisil S. Immunophenotypic profile of adult acute myeloid leukemia (AML): analysis of 267 cases in Thailand. Asian Pac J Allergy Immunol. 2003;21:153-60 pubmed
    ..Our study represents the largest series of AML ever investigated in the Southeast Asian region. ..
  40. Jin Xiang F, Xiaofeng S, Jun Chuan Q, Yan G, Xue Guang Z. Homing efficiency and hematopoietic reconstitution of bone marrow-derived stroma cells expanded by recombinant human macrophage-colony stimulating factor in vitro. Exp Hematol. 2004;32:1204-11 pubmed
    ..The ability to easily expand human stromal cells, which support survival and proliferation of CD34+ cells, has many important clinical applications for hematopoietic disorders. ..
  41. Honda Y, Manabe A, Tsuchida M, Zaike Y, Masunaga A, Inoue M, et al. Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children. Int J Hematol. 2008;88:524-529 pubmed publisher
    ..Five with group A and seven with group B undergoing SCT are alive at a median of 3 years after diagnosis. Erythroblast-rich RAEB and AML M6a in children have similar characteristics and may belong to a single disease entity. ..
  42. Woźniak J. Two methods for the quantitative analysis of surface antigen expression in acute myeloid leukemia (AML). Folia Histochem Cytobiol. 2004;42:195-9 pubmed
    ..This may be helpful in identification of leukemic cells in the diagnostics of minimal residual disease after treatment in AML patients...
  43. Smetana K, Mikulenkova D, Klamova H. A short note on the nuclear diameter in human early granulocytic progenitors. Hematology. 2006;11:399-401 pubmed
    ..In addition, the results of the present study also indicated that the nuclear diameter in myeloblasts as well as promyelocytes of studied patients was not substantially influenced by the cytostatic therapy with imatinib mesylate...
  44. Loken M, Chu S, Fritschle W, Kalnoski M, Wells D. Normalization of bone marrow aspirates for hemodilution in flow cytometric analyses. Cytometry B Clin Cytom. 2009;76:27-36 pubmed publisher
  45. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, et al. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Blood. 2009;113:3172-81 pubmed publisher
    ..Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene...
  46. Macukanovic Golubovic L, Rancić G, Milenović M, Marjanovic G, Vojvodić S, Golubovic Z. [Morphometrical analysis of bone marrow metamyelocyte in pernicious anemia]. Med Pregl. 2008;61:562-5 pubmed
    ..The aim of this study was to perform the quantification of metamyelocyte of the bone marrow in pernicious anemia...
  47. Ohgami R, Chisholm K, Ma L, Arber D. E-cadherin is a specific marker for erythroid differentiation and has utility, in combination with CD117 and CD34, for enumerating myeloblasts in hematopoietic neoplasms. Am J Clin Pathol. 2014;141:656-64 pubmed publisher
    ..However, the specificity of E-cadherin in bone marrow specimens for erythroblasts vs myeloblasts or other early hematopoietic precursors in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) has not been fully elucidated...
  48. Monfardini E, Van Merris V, Paape M, Duchateau L, Burvenich C. L-selectin and chemotaxis throughout bone marrow granulocyte maturation in the bovine. J Dairy Sci. 2004;87:3350-7 pubmed
    ..Further, BM cells are capable of migration starting at the metamyelocytic stage, and compared with BM cells, circulating neutrophils are more chemotactively active...
  49. Sperr W, Drach J, Hauswirth A, Ackermann J, Mitterbauer M, Mitterbauer G, et al. Myelomastocytic leukemia: evidence for the origin of mast cells from the leukemic clone and eradication by allogeneic stem cell transplantation. Clin Cancer Res. 2005;11:6787-92 pubmed
    ..The origin of mast cells in these patients is presently unknown...
  50. Zanocco Marani T, Vignudelli T, Gemelli C, Pirondi S, Testa A, Montanari M, et al. Tfe3 expression is closely associated to macrophage terminal differentiation of human hematopoietic myeloid precursors. Exp Cell Res. 2006;312:4079-89 pubmed
  51. Zhang H, Basu S, Wu F, Begley C, Saris C, Dunn A, et al. Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF. J Leukoc Biol. 2007;82:915-25 pubmed
    ..Third, NPA production by G-CSF(-/-)/GM-CSF(-/-)/M-CSF(-/-) fibroblasts is enhanced by supplementing culture medium with M-CSF. Thus, stimulation of c-fms by M-CSF is a prerequisite for the production of NPA...
  52. Murthy A, Shao Y, Narala S, Molyneux S, Zuniga Pflucker J, Khokha R. Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. Immunity. 2012;36:105-19 pubmed publisher
    ..Our findings uncover an essential role of ADAM17 in the adult epidermis, demonstrating a gatekeeper function of the ADAM17-Notch-c-Fos triad in barrier immunity...
  53. Liu Y, Liu H, Cao H, Song B, Zhang W, Zhang W. PBK/TOPK mediates promyelocyte proliferation via Nrf2-regulated cell cycle progression and apoptosis. Oncol Rep. 2015;34:3288-96 pubmed
    ..Our results provide new insights into the molecular mechanism of PBK/TOPK-mediated promyelocyte proliferation and shed light on the pathogenesis of AML. ..
  54. Liso V, Bennett J. Morphological and cytochemical characteristics of leukaemic promyelocytes. Best Pract Res Clin Haematol. 2003;16:349-55 pubmed
    ..In addition to morphological examination, cytochemical investigations (peroxidase chloroacetate-esterase, etc.) may help further in defining the cytology of leukaemic cells in APL...
  55. Klobusicka M, Kusenda J, Babusikova O. Myeloid enzymes profile related to the immunophenotypic characteristics of blast cells from patients with acute myeloid leukemia (AML) at diagnosis. Neoplasma. 2005;52:211-8 pubmed
  56. Domnikova N, Degtyareva V, Mukhin O, Nepomnyashchikh L. Hemogram and myelogram in progressing non-Hodgkin's lymphomas. Bull Exp Biol Med. 2005;140:83-7 pubmed
    ..Changes in myelogram attesting to anemia and suppressed erythropoiesis before chemotherapy are additional prognostic factors indicating obligatory intensification of chemotherapy for patients with aggressive non-Hodgkin's lymphomas...
  57. Pal R, Monaghan S, Hassett A, Mapara M, Schafer P, Roodman G, et al. Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia. Blood. 2010;115:605-14 pubmed publisher
    ..High levels of cathepsin G subsequently may increase the risk of VTE. To our knowledge, this is the first report investigating the underlying mechanism of IMiD-induced neutropenia and increased risk of VTE in multiple myeloma...
  58. Dong H, Kung J, Bhardwaj V, McGill J. Flow cytometry rapidly identifies all acute promyelocytic leukemias with high specificity independent of underlying cytogenetic abnormalities. Am J Clin Pathol. 2011;135:76-84 pubmed publisher
    ..FCM effectively provides independent detection of APL during diagnostic workup and harmonizes with the subsequent molecular cytogenetic diagnosis...
  59. Stein E, Tallman M. Provocative pearls in diagnosing and treating acute promyelocytic leukemia. Oncology (Williston Park). 2012;26:636-41 pubmed
  60. Yamamoto C, Banaiee N, Yount N, Patel B, Selsted M. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. J Leukoc Biol. 2004;75:332-41 pubmed
    ..These data identify functional trans- and cis-elements that regulate rat defensin gene expression in high defensin-expressing promyelocytic cells...
  61. Thapa B, Omar A, Arshad S, Hair Bejo M. Detection of avian leukosis virus subgroup J in chicken flocks from Malaysia and their molecular characterization. Avian Pathol. 2004;33:359-63 pubmed
    ..2%) and were close to HPRS-103 with identities between 97.4 and 99.3%. This study indicates that ALV-J-specific sequences can be detected by polymerase chain reaction from frozen tissue samples with and without myelocytic infiltration...
  62. Kozłowska Skrzypczak M, Hansz J, Sawinski K, Komarnicki M. [Suppressive effect of high-dose chemotherapy (HDC) on the clonal growth of grafted peripheral blood granulocyte progenitors is reduced 72 hours after completion of HDC]. Pol Arch Med Wewn. 2005;113:431-7 pubmed
    ..We have also shown that third day after completion of HDC is the optimal time for the infusion of HSC. The time of hematological reconstituton is related in all investigated pts and independently on the HDC-program (p>0.05)...
  63. De Lerma Barbaro A, De Ambrosis A, Banelli B, Li Pira G, Aresu O, Romani M, et al. Methylation of CIITA promoter IV causes loss of HLA-II inducibility by IFN-gamma in promyelocytic cells. Int Immunol. 2008;20:1457-66 pubmed publisher
    ..Therefore hyper-methylation of CIITA promoter IV may be a relevant mechanism of epigenetic control preventing HLA-II IFN-gamma inducibility in the myelomonocytic cell lineage...
  64. Makowska J, Grzegorczyk J, Cieslak M, Bienkiewicz B, Kowalski M. Recruitment of CD34+ progenitor cells into peripheral blood and asthma severity. Ann Allergy Asthma Immunol. 2008;101:402-6 pubmed publisher
    ..Previous studies have suggested that the number of progenitor cells is elevated in the peripheral blood of asthmatic patients and that the number of progenitors correlate with the severity of the disease...
  65. Arellano M, Pakkala S, Langston A, Tighiouart M, Pan L, Chen Z, et al. Early clearance of peripheral blood blasts predicts response to induction chemotherapy in acute myeloid leukemia. Cancer. 2012;118:5278-82 pubmed publisher
    ..Early marrow blast clearance 14 days after induction chemotherapy is an independent prognostic indicator of outcomes in acute myeloid leukemia (AML)...
  66. Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, et al. Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study. Leuk Res. 2012;36:1229-36 pubmed publisher
    ..Logistic regression analyses showed that, in addition to myeloblast percentages, the expression of CD7 and B7-H1 on myeloblasts was independently associated with AL-MDS patients...
  67. Gilmore W, Olwill S, McGlynn H, Alexander H. Annexin A2 expression during cellular differentiation in myeloid cell lines. Biochem Soc Trans. 2004;32:1122-3 pubmed
    ..Annexin A2 may, therefore, be an important player in cellular differentiation and its disorders...
  68. Pessina A, Croera C, Bayo M, Malerba I, Passardi L, Cavicchini L, et al. A methylcellulose microculture assay for the in vitro assessment of drug toxicity on granulocyte/macrophage progenitors (CFU-GM). Altern Lab Anim. 2004;32:17-23 pubmed
  69. Perez C, Revilla C, Alvarez B, Chamorro S, Correa C, Domenech N, et al. Phenotypic and functional characterization of porcine granulocyte developmental stages using two new markers. Dev Comp Immunol. 2007;31:296-306 pubmed
    ..By using multiparameter flow cytometric analysis, we have performed a phenotypic and functional characterization of the granulocyte subsets identified by the combination of 6D10 and 2B2 antigens...
  70. Li R, Huang J, Sun L, Feng X. [Gene expression of OAZ pathway in the patients of systemic lupus erythematosus]. Zhonghua Yi Xue Za Zhi. 2009;89:2068-71 pubmed
    ..To explore the role of Olf/EBF associated zinc finger protein (OAZ) pathway in the RNA expression level in patients with systemic lupus erythematosus (SLE)...
  71. Machaczka M, Wahlin B, Piatkowska Jakubas B, Rucinska M, Jurczak W, Balana Nowak A, et al. Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results. Med Oncol. 2012;29:2070-6 pubmed publisher
    ..Further prospective trials are needed to obtain more information concerning the association between PGP and lymphoid antigens in AML, which would put our results in their ultimate proper context...
  72. Aguilar A, Meunier A, Strehl L, Martinovic J, Bonniere M, Attie Bitach T, et al. Analysis of human samples reveals impaired SHH-dependent cerebellar development in Joubert syndrome/Meckel syndrome. Proc Natl Acad Sci U S A. 2012;109:16951-6 pubmed publisher
    ..Our results, obtained from the analysis of human samples, show that the hemispheres and the vermis are affected in JS/MKS and provide evidence of a defective cellular mechanism in these pathologic processes...
  73. Ma Y, Adjemian S, Mattarollo S, Yamazaki T, Aymeric L, Yang H, et al. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity. 2013;38:729-41 pubmed publisher
    ..Our results identify a subset of tumor-infiltrating leukocytes as therapy-relevant antigen-presenting cells...
  74. Lothstein L, Savranskaya L, Barrett C, Israel M, Sweatman T. N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx. Anticancer Drugs. 2006;17:495-502 pubmed
    ..PTPC-independent mitochondrial activation by AD 198 is consistent with the inability of Bcl-2 and Bcl-XL expression to block AD 198-induced apoptosis...
  75. Pass M, Borregaard N, Cowland J. Derangement of transcription factor profiles during in vitro differentiation of HL60 and NB4 cells. Leuk Res. 2007;31:827-37 pubmed
    ..These data illustrate the limitations of cell lines as models for normal granulopoiesis...
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    ..Also, the clinical prognosis was closely related to the bone marrow features. Type I is the dominant type which is usually associated with worse clinical prognosis compared to type II...