basophils

Summary

Summary: Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.

Top Publications

  1. Torrero M, Hübner M, Larson D, Karasuyama H, Mitre E. Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis. J Immunol. 2010;185:7426-34 pubmed publisher
    ..Because basophils have been shown to be substantial contributors of IL-4 in helminth infections, and because basophils are capable ..
  2. Macglashan D, Saini S. Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. J Allergy Clin Immunol. 2013;132:906-11.e1-4 pubmed publisher
    ..Treatment with omalizumab results in a markedly increased sensitivity of basophils to IgE-mediated stimulation in terms of the number of IgE molecules required to produce a given response...
  3. Hübner M, Larson D, Torrero M, Mueller E, Shi Y, Killoran K, et al. Anti-Fc?R1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice. Clin Immunol. 2011;141:205-17 pubmed publisher
    ..As helminths cause chronic IgE-mediated activation of basophils and mast cells we hypothesized that continuous activation of these cells could prevent diabetes onset in ..
  4. Grundström J, Reimer J, Magnusson S, Nilsson G, Wernersson S, Hellman L. Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins. PLoS ONE. 2012;7:e48308 pubmed publisher
    b>Basophils are blood cells of low abundance associated with allergy, inflammation and parasite infections...
  5. Rodriguez Gomez M, Talke Y, Goebel N, Hermann F, Reich B, Mack M. Basophils support the survival of plasma cells in mice. J Immunol. 2010;185:7180-5 pubmed publisher
    We have previously shown that basophils support humoral memory immune responses by increasing B cell proliferation and Ig production as well as inducing a Th2 and B helper phenotype in T cells...
  6. Siracusa M, Kim B, Spergel J, Artis D. Basophils and allergic inflammation. J Allergy Clin Immunol. 2013;132:789-801; quiz 788 pubmed publisher
    b>Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals...
  7. Voehringer D. Basophils in allergic immune responses. Curr Opin Immunol. 2011;23:789-93 pubmed publisher
    b>Basophils are rare effector cells of the innate immune system. They are generally associated with type 2 immune responses that develop during helminth infections and allergic reactions...
  8. Knol E, Olszewski M. Basophils and mast cells: Underdog in immune regulation?. Immunol Lett. 2011;138:28-31 pubmed publisher
    ..Especially, via the release of pro- and anti-inflammatory cytokines basophils and mast cells now can steer an immune response...
  9. Kitzmuller C, Nagl B, Deifl S, Walterskirchen C, Jahn Schmid B, Zlabinger G, et al. Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Allergy. 2012;67:593-600 pubmed publisher
    Several studies in mice have recently shown that basophils can act as antigen-presenting cells (APC) inducing Th2-mediated immune responses against parasites or protease allergens...

More Information

Publications73

  1. Kuroda E, Antignano F, Ho V, Hughes M, Ruschmann J, Lam V, et al. SHIP represses Th2 skewing by inhibiting IL-4 production from basophils. J Immunol. 2011;186:323-32 pubmed publisher
    ..Exploring the reason for this Th2 skewing, we found that freshly isolated SHIP(-/-) splenic and bone marrow basophils are present in elevated numbers and secrete far more IL-4 in response to IL-3 or to Fc?RI stimulation than do WT ..
  2. Suurmond J, Stoop J, Rivellese F, Bakker A, Huizinga T, Toes R. Activation of human basophils by combined toll-like receptor- and Fc?RI-triggering can promote Th2 skewing of naive T helper cells. Eur J Immunol. 2014;44:386-96 pubmed publisher
    b>Basophils are mostly known for their involvement in allergic reactions. Recent studies in mice indicate a role for basophils in the induction of adaptive immunity, especially T helper 2 (Th2) responses...
  3. Ugajin T, Satoh T, Kanamori T, Aritake K, Urade Y, Yokozeki H. Fc?RI, but not Fc?R, signals induce prostaglandin D2 and E2 production from basophils. Am J Pathol. 2011;179:775-82 pubmed publisher
    ..It has long been thought that basophils, in contrast to mast cells, do not synthesize PGs, although they do release leukotrienes and platelet-activating ..
  4. Watanabe T, Yamashita K, Sakurai T, Kudo M, Shiokawa M, Uza N, et al. Toll-like receptor activation in basophils contributes to the development of IgG4-related disease. J Gastroenterol. 2013;48:247-53 pubmed publisher
    ..Since basophils function as antigen-presenting cells for Th2 responses, we tried to clarify the role of basophils in the ..
  5. Dölle S, Lehmann K, Schwarz D, Weckwert W, Scheler C, George E, et al. Allergenic activity of different tomato cultivars in tomato allergic subjects. Clin Exp Allergy. 2011;41:1643-52 pubmed publisher
    ..Therefore, identification of tomato cultivars with reduced allergenicity would potentially increase the quality of life of affected subjects...
  6. North S, von Gunten S, Antonopoulos A, Trollope A, Macglashan D, Jang Lee J, et al. Glycomic analysis of human mast cells, eosinophils and basophils. Glycobiology. 2012;22:12-22 pubmed publisher
    In allergic diseases such as asthma, eosinophils, basophils and mast cells, through release of preformed and newly generated mediators, granule proteins and cytokines, are recognized as key effector cells...
  7. Herbst T, Sichelstiel A, Schär C, Yadava K, Burki K, Cahenzli J, et al. Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med. 2011;184:198-205 pubmed publisher
    ..The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora...
  8. Voehringer D. Basophils in immune responses against helminths. Microbes Infect. 2011;13:881-7 pubmed publisher
    b>Basophils are a major source of IL-4 and IL-13, two key cytokines that orchestrate expulsion of gastrointestinal nematodes in different mouse models...
  9. Kumari D, Arora N, Kasera R, Sridhara S, Kumar R, Singh B. Isolation and characterization of a 28 kDa major allergen from blackgram (Phaseolus mungo). Immunobiology. 2012;217:895-904 pubmed publisher
    ..In conclusion, the purified 28 kDa protein is a potent major allergen that may have implication in diagnosis of blackgram allergy...
  10. Arias K, Chu D, Flader K, Botelho F, Walker T, Arias N, et al. Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J Allergy Clin Immunol. 2011;127:1552-61.e1 pubmed publisher
    ..Food-induced anaphylaxis is often a severe allergic reaction characterized by multiorgan dysfunction and a potentially fatal outcome...
  11. Sumbayev V, Yasinska I, Oniku A, Streatfield C, Gibbs B. Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils. PLoS ONE. 2012;7:e34259 pubmed publisher
    ..showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the ..
  12. Gernez Y, Tirouvanziam R, Yu G, Ghosn E, Reshamwala N, Nguyen T, et al. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol. 2011;154:318-27 pubmed publisher
    b>Basophils contribute to anaphylaxis and allergies. We examined the utility of assessing basophil-associated surface antigens (CD11b/CD63/CD123/CD203c/CD294) in characterizing and monitoring subjects with nut allergy.
  13. Korosec P, Mavsar N, Bajrovic N, Silar M, Mrhar A, Kosnik M. Basophil responsiveness and clinical picture of acetylsalicylic acid intolerance. Int Arch Allergy Immunol. 2011;155:257-62 pubmed publisher
    ..We wanted to evaluate specific responsiveness of basophils to ASA in correlation with the clinical picture.
  14. Karasuyama H, Mukai K, Obata K, Tsujimura Y, Wada T. Nonredundant roles of basophils in immunity. Annu Rev Immunol. 2011;29:45-69 pubmed publisher
    b>Basophils are the rarest granulocytes and represent less than 1% of peripheral blood leukocytes...
  15. Karasuyama H, Wada T, Yoshikawa S, Obata K. Emerging roles of basophils in protective immunity against parasites. Trends Immunol. 2011;32:125-30 pubmed publisher
    b>Basophils, the least common type of granulocyte, have long been considered as minor effector cells in allergic responses because of their ability to release allergy-inducing chemical mediators such as histamine and leukotriene C4...
  16. Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol. 2011;186:5766-71 pubmed publisher
    ..In this study, we show that the whole population of basophils constitutively expresses ASGM1 as well as CD49b (DX5) as does the NK cell population and was ablated in vivo by ..
  17. Gibbs B, Levi Schaffer F. H? receptors in mast cells and basophils: a new therapeutic target for allergy?. Front Biosci (Landmark Ed). 2012;17:430-7 pubmed
    It has long been recognised that mast cells and basophils are prominent sources of preformed histamine in humans and that this biogenic amine serves as one of the most important inflammatory mediators...
  18. Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, et al. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J Immunol. 2011;186:5254-60 pubmed publisher
    b>Basophils are the rarest leukocytes in human blood, but they are now recognized as one of the most important immunomodulatory as well as effector cells in allergic inflammation...
  19. Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss M, et al. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A. 2012;109:14954-9 pubmed publisher
    b>Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection...
  20. Yasuda H, Aritaka N, Ando J, Hirama M, Komatsu N, Hirano T. Chronic myelogenous leukemia with mild basophilia as the predominant manifestation at presentation. Intern Med. 2011;50:501-2 pubmed
    ..This case reconfirms the importance of basophilia as a clinical manifestation of CML, and BCR-ABL FISH analysis should always be applied to cases of basophilia, even when the basophilia is modest and no other features of CML are present...
  21. Ito Y, Satoh T, Takayama K, Miyagishi C, Walls A, Yokozeki H. Basophil recruitment and activation in inflammatory skin diseases. Allergy. 2011;66:1107-13 pubmed publisher
    b>Basophils are blood leukocytes constituting less than 1% of leukocytes...
  22. van Panhuys N, Prout M, Forbes E, Min B, Paul W, Le Gros G. Basophils are the major producers of IL-4 during primary helminth infection. J Immunol. 2011;186:2719-28 pubmed publisher
    ..CD4(+) T cells and basophils are thought to be the key cell types that produce IL-4 during a type 2 response...
  23. Schroeder J. Basophils: emerging roles in the pathogenesis of allergic disease. Immunol Rev. 2011;242:144-60 pubmed publisher
    After approximately 130 years since their discovery as rare granulocytes that circulate in blood, basophils are just now gaining respect as significant contributors in the pathogenesis underlying allergic inflammation and disease...
  24. Sabato V, Verweij M, Bridts C, Levi Schaffer F, Gibbs B, De Clerck L, et al. CD300a is expressed on human basophils and seems to inhibit IgE/Fc?RI-dependent anaphylactic degranulation. Cytometry B Clin Cytom. 2012;82:132-8 pubmed publisher
    ..However, in the context of basophil biology, the inhibitory mechanisms that control these processes are still poorly understood...
  25. Wakahara K, Baba N, Van V, Bégin P, Rubio M, Ferraro P, et al. Human basophils interact with memory T cells to augment Th17 responses. Blood. 2012;120:4761-71 pubmed publisher
    b>Basophils are a rare population of granulocytes that have long been associated with IgE-mediated and Th2-associated allergic diseases. However, the role of basophils in Th17 and/or Th1 diseases has not been reported...
  26. Qiu H, Wong C, Chu I, Hu S, Lam C. Muramyl dipeptide mediated activation of human bronchial epithelial cells interacting with basophils: a novel mechanism of airway inflammation. Clin Exp Immunol. 2013;172:81-94 pubmed publisher
    ..activation of the NOD2 ligand MDP on primary human bronchial epithelial cells (HBE) co-cultured with human basophils was investigated...
  27. Sullivan B, Liang H, Bando J, WU D, Cheng L, McKerrow J, et al. Genetic analysis of basophil function in vivo. Nat Immunol. 2011;12:527-35 pubmed publisher
    Contributions by basophils to allergic and helminth immunity remain incompletely defined...
  28. Obata Ninomiya K, Ishiwata K, Tsutsui H, Nei Y, Yoshikawa S, Kawano Y, et al. The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med. 2013;210:2583-95 pubmed publisher
    ..B cell- or IgE receptor Fc?RI-deficient mice showed impaired larval trapping in the skin. Selective ablation of basophils, but not mast cells, abolished the larval trapping, leading to increased worm burden in the lung and hence ..
  29. Pelleau S, Diop S, Dia Badiane M, Vitte J, Beguin P, Nato F, et al. Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein. Infect Immun. 2012;80:2963-70 pubmed publisher
    ..Unstimulated basophils from MM had significantly lower levels of CD203c expression compared to those from HC and SM...
  30. Cassard L, Jönsson F, Arnaud S, Daëron M. Fc? receptors inhibit mouse and human basophil activation. J Immunol. 2012;189:2995-3006 pubmed publisher
    Besides high-affinity IgE receptors (Fc?RI), human basophils express activating (Fc?RIIA) and inhibitory (Fc?RIIB) low-affinity IgG receptors. IgG receptors (Fc?R) were also found on mouse basophils, but not identified...
  31. Sharma M, Hegde P, Aimanianda V, Beau R, Maddur M, Sénéchal H, et al. Circulating human basophils lack the features of professional antigen presenting cells. Sci Rep. 2013;3:1188 pubmed publisher
    Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC)...
  32. Nei Y, Obata Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, et al. GATA-1 regulates the generation and function of basophils. Proc Natl Acad Sci U S A. 2013;110:18620-5 pubmed publisher
    ..However, the role of GATA-1 in basophils remains elusive...
  33. Jönsson F, Mancardi D, Kita Y, Karasuyama H, Iannascoli B, Van Rooijen N, et al. Mouse and human neutrophils induce anaphylaxis. J Clin Invest. 2011;121:1484-96 pubmed publisher
    ..by IgG antibodies, and an IgG1-induced passive type of systemic anaphylaxis has been reported to depend on basophils. In addition, it was found that neither mast cells nor basophils were required in mouse models of active ..
  34. Glaumann S, Nopp A, Johansson S, Rudengren M, Borres M, Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy. 2012;67:242-7 pubmed publisher
    ..The aim of the study was to evaluate the basophil allergen threshold sensitivity (CD-sens) and antibodies to peanut allergen components in relation to DBPCFC in the diagnoses of peanut allergy in children...
  35. Voehringer D. Protective and pathological roles of mast cells and basophils. Nat Rev Immunol. 2013;13:362-75 pubmed publisher
    Mast cells and basophils are potent effector cells of the innate immune system, and they have both beneficial and detrimental functions for the host...
  36. Patil S, Wang J, Song Y, Noone S, Yang N, Wallenstein S, et al. Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study. J Allergy Clin Immunol. 2011;128:1259-1265.e2 pubmed publisher
    ..Food Allergy Herbal Formula-2 (FAHF-2) blocks peanut-induced anaphylaxis in a murine model of peanut-induced anaphylaxis. It was found to be safe and well tolerated in an acute phase I study of patients with food allergy...
  37. He S, Zhang H, Zeng X, Yang P. Self-amplification mechanisms of mast cell activation: a new look in allergy. Curr Mol Med. 2012;12:1329-39 pubmed
    ..Since even IgE dependent allergic reactions are carried out through activation of mast cells and basophils, and all allergens mentioned above can activate these cells, we hypothesize that allergic reactions are mast ..
  38. Siracusa M, Saenz S, Hill D, Kim B, Headley M, Doering T, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 2011;477:229-33 pubmed publisher
    ..that disruption of TSLP-TSLPR interactions results in defective basophil responses, and that TSLPR-sufficient basophils can restore T(H)2-cell-dependent immunity in vivo...
  39. Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, et al. GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J Biol Chem. 2012;287:32689-96 pubmed
    ..The target cells for IL-33 are restricted in some hematopoietic lineages, including mast cells, basophils, eosinophils, Th2 cells, natural killer cells, and dendritic cells...
  40. Nakanishi K. Basophils as APC in Th2 response in allergic inflammation and parasite infection. Curr Opin Immunol. 2010;22:814-20 pubmed publisher
    b>Basophils are important effector cells, which contribute to protection against helminths and execute proinflammatory effector function during allergic inflammation...
  41. Ozdemir S, Guloglu D, Sin B, Elhan A, Ikinciogullari A, Misirligil Z. Reliability of basophil activation test using CD203c expression in diagnosis of pollen allergy. Am J Rhinol Allergy. 2011;25:e225-31 pubmed publisher
    ..This study was designed to investigate the efficacy of basophil activation test via CD203c in the diagnosis of pollen allergy...
  42. Karasuyama H, Obata K, Wada T, Tsujimura Y, Mukai K. Newly appreciated roles for basophils in allergy and protective immunity. Allergy. 2011;66:1133-41 pubmed publisher
    b>Basophils are evolutionarily conserved in many animal species, in spite of the fact that they account for <1% of peripheral blood leukocyte...
  43. Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, et al. Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity. 2013;38:570-80 pubmed publisher
    ..Thus, inflammatory monocytes can be converted from being proinflammatory to anti-inflammatory under the influence of basophils in allergic reactions.
  44. Schneider E, Machavoine F, Bricard Rignault R, Levasseur M, Petit Bertron A, Gautron S, et al. Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands. J Allergy Clin Immunol. 2011;128:864-871.e2 pubmed publisher
    Murine basophils can contribute to the T(H)2 polarization of the immune response by providing rapidly large amounts of IL-4, which suggests that pharmacologic downregulation of this cytokine might provide a strategy to attenuate ..
  45. Van Beek A, Knol E, de Vos P, Smelt M, Savelkoul H, van Neerven R. Recent developments in basophil research: do basophils initiate and perpetuate type 2 T-helper cell responses?. Int Arch Allergy Immunol. 2013;160:7-17 pubmed publisher
    b>Basophils account for only 0.1-1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time...
  46. Pulendran B, Artis D. New paradigms in type 2 immunity. Science. 2012;337:431-5 pubmed publisher
  47. Eckl Dorna J, Ellinger A, Blatt K, Ghanim V, Steiner I, Pavelka M, et al. Basophils are not the key antigen-presenting cells in allergic patients. Allergy. 2012;67:601-8 pubmed publisher
    Recent data obtained in mouse models have initiated a controversy whether basophils are the key antigen-presenting cells (APCs) in allergy...
  48. Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, et al. Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness. J Immunol. 2012;188:1809-18 pubmed publisher
    ..system using Il4 enhancer elements previously shown to be specific for IL-4 production in mast cells (MCs) or basophils (Mas-TRECK and Bas-TRECK mice)...
  49. Giacomin P, Siracusa M, Walsh K, Grencis R, Kubo M, Comeau M, et al. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol. 2012;189:4371-8 pubmed publisher
    ..Recent studies highlighted that basophils can promote Th2 cytokine-mediated inflammation and that phenotypic and functional heterogeneity exists between ..
  50. Patil S, Shreffler W. Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation. Clin Exp Immunol. 2012;167:59-66 pubmed publisher
    ..Studies of basophils during immunotherapy have provided insight into underlying immune mechanisms and support the potential use of ..
  51. Hill D, Siracusa M, Abt M, Kim B, Kobuley D, Kubo M, et al. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med. 2012;18:538-46 pubmed publisher
    ..Collectively, these results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to T(H)2 cytokine-dependent inflammation and allergic disease...
  52. Gentinetta T, Pecaric Petkovic T, Wan D, Falcone F, Dahinden C, Pichler W, et al. Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. J Allergy Clin Immunol. 2011;128:1227-1234.e5 pubmed publisher
    ..Coincubation of patient sera with donor basophils and measuring their degranulation in vitro could be a safe alternative but has shown inconsistent results.
  53. Wald M, Kahlert H, Reese G, Krontal N, Zafred D, Keller W, et al. Hypoallergenic mutants of the Timothy grass pollen allergen Phl p 5 generated by proline mutations. Int Arch Allergy Immunol. 2012;159:130-42 pubmed publisher
    ..Native Phl p 5 is formed by ?-helical regions separated by regions containing prolines. In order to generate hypoallergenic mutants, we studied the effect of proline mutations in single and multiple regions...
  54. Poulsen B, Poulsen L, Jensen B. Detection of MHC class II expression on human basophils is dependent on antibody specificity but independent of atopic disposition. J Immunol Methods. 2012;381:66-9 pubmed publisher
    A debate has recently arisen as to whether murine basophils can function as antigen presenting cells in allergic inflammation...
  55. Moniaga C, Jeong S, Egawa G, Nakajima S, Hara Chikuma M, Jeon J, et al. Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice. Am J Pathol. 2013;182:841-51 pubmed publisher
    ..These results suggest that possibly through the PAR-2 activation in KCs, filaggrin deficiency induces TSLP production and basophil accumulation, which play important roles in the establishment of AD...
  56. Haenuki Y, Matsushita K, Futatsugi Yumikura S, Ishii K, Kawagoe T, Imoto Y, et al. A critical role of IL-33 in experimental allergic rhinitis. J Allergy Clin Immunol. 2012;130:184-94.e11 pubmed publisher
    ..We reported previously that serum levels of IL-33 are significantly increased in patients with allergic rhinitis (AR). However, very little is known about the role of IL-33 for the development of AR...
  57. Bosch X, Lozano F, Cervera R, Ramos Casals M, Min B. Basophils, IgE, and autoantibody-mediated kidney disease. J Immunol. 2011;186:6083-90 pubmed publisher
    b>Basophils are of interest in immunology due to their ability to produce a Th2-signature cytokine, IL-4, following activation...
  58. MacGlashan D, Honigberg L, Smith A, Buggy J, Schroeder J. Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor. Int Immunopharmacol. 2011;11:475-9 pubmed publisher
    The study of receptor-mediated signaling in human basophils is often limited by the availability of selective pharmacological agents...
  59. MacGlashan D. Subthreshold desensitization of human basophils re-capitulates the loss of Syk and Fc?RI expression characterized by other methods of desensitization. Clin Exp Allergy. 2012;42:1060-70 pubmed publisher
    ..However, most signalling studies of human basophils have identified changes in signalling by using other methods of inducing cellular desensitization.
  60. Geering B, Stoeckle C, Conus S, Simon H. Living and dying for inflammation: neutrophils, eosinophils, basophils. Trends Immunol. 2013;34:398-409 pubmed publisher
    Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and sterile inflammation...
  61. Falcone F, Knol E, Gibbs B. The role of basophils in the pathogenesis of allergic disease. Clin Exp Allergy. 2011;41:939-47 pubmed publisher
    There has been much controversy surrounding the importance of basophils in allergy. These cells are, after all, comparatively rare and yet they display remarkable potential to contribute to the symptoms of allergic inflammation...
  62. Wisniewski J, Borish L. Novel cytokines and cytokine-producing T cells in allergic disorders. Allergy Asthma Proc. 2011;32:83-94 pubmed publisher
    ..TSLP, and IL-33 activity results in activation of Th2 cells, mast cells, dendritic cells, eosinophils, and basophils, leading to inflammatory processes that define allergic disease...
  63. Charles N, Rivera J. Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus. Curr Allergy Asthma Rep. 2011;11:378-87 pubmed publisher
    ..Here we describe the recent work focusing on autoreactive IgE and the activation of basophils as promoting the production of autoantibodies in SLE...
  64. Blom L, Poulsen B, Jensen B, Hansen A, Poulsen L. IL-33 induces IL-9 production in human CD4+ T cells and basophils. PLoS ONE. 2011;6:e21695 pubmed publisher
    ..Here, we report that IL-33 can initiate IL-9 protein secretion in vitro in human CD4+ T cells and basophils isolated from peripheral blood...