hemocytes

Summary

Summary: Any blood or formed element especially in invertebrates.

Top Publications

  1. King J, HILLYER J. Infection-induced interaction between the mosquito circulatory and immune systems. PLoS Pathog. 2012;8:e1003058 pubmed publisher
    Insects counter infection with innate immune responses that rely on cells called hemocytes. Hemocytes exist in association with the insect's open circulatory system and this mode of existence has likely influenced the organization and ..
  2. Toubiana M, Gerdol M, Rosani U, Pallavicini A, Venier P, Roch P. Toll-like receptors and MyD88 adaptors in Mytilus: complete cds and gene expression levels. Dev Comp Immunol. 2013;40:158-66 pubmed publisher
    ..All MgTLRs were constitutively expressed in digestive gland whereas only 4 of them were also present in hemocytes. On the opposite, the 3 MgMyD88s were constitutively expressed in all the tissues. In vivo challenge of M...
  3. Zibaee A, Bandani A, Talaei Hassanlouei R, Malagoli D. Cellular immune reactions of the sunn pest, Eurygaster integriceps, to the entomopathogenic fungus, Beauveria bassiana and its secondary metabolites. J Insect Sci. 2011;11:138 pubmed publisher
    In this study, five morphological types of circulating hemocytes were recognized in the hemolymph of the adult sunn pest, Eurygaster integriceps Puton (Hemiptera: Scutelleridae), namely prohemocytes, plasmatocytes, granulocytes, ..
  4. Brulle F, Jeffroy F, Madec S, Nicolas J, Paillard C. Transcriptomic analysis of Ruditapes philippinarum hemocytes reveals cytoskeleton disruption after in vitro Vibrio tapetis challenge. Dev Comp Immunol. 2012;38:368-76 pubmed publisher
    ..were performed to construct cDNA libraries enriched in up- or down-regulated transcripts from clam immune cells, hemocytes, after a 3-h in vitro challenge with cultured V. tapetis...
  5. Noonin C, Lin X, Jiravanichpaisal P, Soderhall K, Söderhäll I. Invertebrate hematopoiesis: an anterior proliferation center as a link between the hematopoietic tissue and the brain. Stem Cells Dev. 2012;21:3173-86 pubmed publisher
    ..Our findings offer an opportunity to learn more about invertebrate hematopoiesis and its connection to the central nervous system, thereby obtaining new information about the evolution of different blood and nerve cell lineages...
  6. Rebelo M, Figueiredo E, Mariante R, Nobrega A, de Barros C, Allodi S. New insights from the oyster Crassostrea rhizophorae on bivalve circulating hemocytes. PLoS ONE. 2013;8:e57384 pubmed publisher
    b>Hemocytes are the first line of defense of the immune system in invertebrates, but despite their important role and enormous potential for the study of gene-environment relationships, research has been impeded by a lack of consensus on ..
  7. Browne N, Heelan M, Kavanagh K. An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes. Virulence. 2013;4:597-603 pubmed publisher
    ..Insect hemocytes recognize pathogens and phagocytose material in a similar manner to neutrophils...
  8. Fan J, Xie Y, Xue J, Zhang Y, Yang Q. Cellular apoptosis of hemocytes from Dendrolimus tabulaeformis Tsai et Liu larvae induced with the secondary metabolites of Beauveria brongniartii (Sacc.) Petch. PLoS ONE. 2013;8:e71600 pubmed publisher
    ..The larvae were inoculated with the SMC solutions by injection in bioassays. Apoptosis of the larval hemocytes was observed using fluorescence microscopy (FM), transmission electron microscopy (TEM), and flow cytometry (FCM)..
  9. Mondal B, Mukherjee T, Mandal L, Evans C, Sinenko S, Martinez Agosto J, et al. Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell. 2011;147:1589-600 pubmed publisher
    ..Similar homeostatic mechanisms are likely to be utilized in other systems that maintain relatively large numbers of progenitors that are not all in direct contact with the cells of the niche...

More Information

Publications122 found, 100 shown here

  1. Xu T, Xie J, Li J, Luo M, Ye S, Wu X. Identification of expressed genes in cDNA library of hemocytes from the RLO-challenged oyster, Crassostrea ariakensis Gould with special functional implication of three complement-related fragments (CaC1q1, CaC1q2 and CaC3). Fish Shellfish Immunol. 2012;32:1106-16 pubmed publisher
    ..And the maximal expression levels at 3 h in post-challenge are about 256, 104 and 64 times higher than the values detected in the control of CaC1q1, CaC1q2 and CaC3, respectively...
  2. de Barros C, Mello A, Allodi S. Norepinephrine depresses the nitric oxide production in the ascidian hemocytes. J Invertebr Pathol. 2012;111:182-5 pubmed publisher
    ..We found that NE depressed the production of nitric oxide (NO) by the hemocytes of ascidians...
  3. Jiang Q, Zhou Z, Wang L, Shi X, Wang J, Yue F, et al. The immunomodulation of inducible nitric oxide in scallop Chlamys farreri. Fish Shellfish Immunol. 2013;34:100-8 pubmed publisher
  4. Duan Y, Liu P, Li J, Li J, Chen P. Immune gene discovery by expressed sequence tag (EST) analysis of hemocytes in the ridgetail white prawn Exopalaemon carinicauda. Fish Shellfish Immunol. 2013;34:173-82 pubmed publisher
    ..distinctive genes associated with immunity, an expressed sequence tag (EST) library was constructed from hemocytes of E. carinicauda...
  5. Husmann G, Abele D, Rosenstiel P, Clark M, Kraemer L, Philipp E. Age-dependent expression of stress and antimicrobial genes in the hemocytes and siphon tissue of the Antarctic bivalve, Laternula elliptica, exposed to injury and starvation. Cell Stress Chaperones. 2014;19:15-32 pubmed publisher
    ..A 454-based RNA sequencing was carried out on tissues and hemocytes of L. elliptica, resulting in 42,525 contigs, of which 48 % was assigned putative functions...
  6. Zhong R, Tang X, Zhan W, Xing J, Sheng X. Expression kinetics of ?-integrin in Chinese shrimp (Fenneropenaeus chinensis) hemocytes following infection with white spot syndrome virus. Fish Shellfish Immunol. 2013;35:539-45 pubmed publisher
    ..potential role of the Fc?Int in the WSSV infection, expression response of Fc?Int to WSSV infection in shrimp hemocytes was investigated after intra-muscular injection with the virus...
  7. Qian C, Liu Y, Fang Q, Min Li Y, Liu S, Ye G, et al. Venom of the ectoparasitoid, Nasonia vitripennis, influences gene expression in Musca domestica hemocytes. Arch Insect Biochem Physiol. 2013;83:211-31 pubmed publisher
    ..We investigated the influence of N. vitripennis venom on the gene expression profile of hemocytes of their hosts, pupae of the housefly, Musca domestica...
  8. Medhioub W, Ramondenc S, Vanhove A, Vergnes A, Masseret E, Savar V, et al. Exposure to the neurotoxic dinoflagellate, Alexandrium catenella, induces apoptosis of the hemocytes of the oyster, Crassostrea gigas. Mar Drugs. 2013;11:4799-814 pubmed publisher
    This study assessed the apoptotic process occurring in the hemocytes of the Pacific oyster, Crassostrea gigas, exposed to Alexandrium catenella, a paralytic shellfish toxins (PSTs) producer...
  9. Breitenbach J, Shelby K, Popham H. Baculovirus induced transcripts in hemocytes from the larvae of Heliothis virescens. Viruses. 2011;3:2047-64 pubmed publisher
    Using RNA-seq digital difference expression profiling methods, we have assessed the gene expression profiles of hemocytes harvested from Heliothis virescens that were challenged with Helicoverpa zea single nucleopolyhedrovirus (HzSNPV)...
  10. Coggins S, Estévez Lao T, HILLYER J. Increased survivorship following bacterial infection by the mosquito Aedes aegypti as compared to Anopheles gambiae correlates with increased transcriptional induction of antimicrobial peptides. Dev Comp Immunol. 2012;37:390-401 pubmed publisher
    ..gambiae, and this correlates with Ae. aegypti's superior ability to kill bacteria in their hemocoels. Hemocytes from both species swiftly phagocytose bacteria, but phagocytosis does not explain Ae...
  11. Kacsoh B, Schlenke T. High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster. PLoS ONE. 2012;7:e34721 pubmed publisher
    ..melanogaster and D. suzukii, and found that D. suzukii constitutively produces up to five times more hemocytes than D. melanogaster...
  12. Altuntaş H, Kılıç A, Uckan F, Ergin E. Effects of gibberellic acid on hemocytes of Galleria mellonella L. (Lepidoptera: Pyralidae). Environ Entomol. 2012;41:688-96 pubmed publisher
    ..doses of the plant growth regulator gibberellic acid (GA(3)) in diet on the number of total and differential hemocytes, frequency of apoptotic, and necrotic hemocytes, mitotic indices, encapsulation, and melanization responses were ..
  13. Bouki E, Dimitriadis V, Kaloyianni M, Dailianis S. Antioxidant and pro-oxidant challenge of tannic acid in mussel hemocytes exposed to cadmium. Mar Environ Res. 2013;85:13-20 pubmed publisher
    The present study investigates the antioxidant and pro-oxidant behavior of tannic acid (TA) in hemocytes of mussel Mytilus galloprovincialis, in the presence or the absence of cadmium (Cd)...
  14. Alves E Silva T, Vasconcellos L, Lopes A, Souto Padron T. The immune response of hemocytes of the insect Oncopeltus fasciatus against the flagellate Phytomonas serpens. PLoS ONE. 2013;8:e72076 pubmed publisher
    ..In this report, using a model of systemic infection, we describe the function of Oncopeltus fasciatus hemocytes in the immune response towards the tomato parasite Phytomonas serpens...
  15. Koutsogiannaki S, Franzellitti S, Fabbri E, Kaloyianni M. Oxidative stress parameters induced by exposure to either cadmium or 17?-estradiol on Mytilus galloprovincialis hemocytes. The role of signaling molecules. Aquat Toxicol. 2014;146:186-95 pubmed publisher
    ..to an estrogen, 17?-estradiol and to a metal, cadmium on oxidative parameters of Mytilus galloprovincialis hemocytes and to elucidate the signaling pathways that probably mediate the studied effects exerted by these two chemicals...
  16. Qin Q, Qin S, Wang L, Lei W. Immune responses and ultrastructural changes of hemocytes in freshwater crab Sinopotamon henanense exposed to elevated cadmium. Aquat Toxicol. 2012;106-107:140-6 pubmed publisher
    ..To investigate the immunotoxicity and ultrastructural changes of hemocytes, specimens of Sinopotamon henanense were exposed to different concentrations of cadmium and the differences in ..
  17. Moreira R, Balseiro P, Planas J, Fuste B, Beltran S, Novoa B, et al. Transcriptomics of in vitro immune-stimulated hemocytes from the Manila clam Ruditapes philippinarum using high-throughput sequencing. PLoS ONE. 2012;7:e35009 pubmed publisher
    ..philippinarum hemocytes by 454-pyrosequencing to identify genes involved in their immune defense against infectious diseases.
  18. Mello D, de Oliveira E, Vieira R, Simoes E, Trevisan R, Dafre A, et al. Cellular and transcriptional responses of Crassostrea gigas hemocytes exposed in vitro to brevetoxin (PbTx-2). Mar Drugs. 2012;10:583-97 pubmed publisher
    b>Hemocytes mediate a series of immune reactions essential for bivalve survival in the environment, however, the impact of harmful algal species and their associated phycotoxins upon bivalve immune system is under debate...
  19. Lolo F, Casas Tinto S, Moreno E. Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. Cell Rep. 2012;2:526-39 pubmed publisher
    ..Finally, we find that most of the clearance of the apoptotic debris is not performed by winners but by recruited hemocytes, which are required for the removal of the apoptotic corpses at the very end...
  20. Renwrantz L, Siegmund E, Woldmann M. Variations in hemocyte counts in the mussel, Mytilus edulis: similar reaction patterns occur in disappearance and return of molluscan hemocytes and vertebrate leukocytes. Comp Biochem Physiol A Mol Integr Physiol. 2013;164:629-37 pubmed publisher
    ..6±5.5% hyalinocytes (15 animals). After 12 or 30days under optimal laboratory conditions, hemocytes in circulation decreased to less than 1×10(6)/mL, the lowest number observed being 5×10(5)cells/mL...
  21. Wu S, Wang F, Huang J, Fang Q, Shen Z, Ye G. Molecular and cellular analyses of a ryanodine receptor from hemocytes of Pieris rapae. Dev Comp Immunol. 2013;41:1-10 pubmed publisher
    ..very few information are accessible about calcium transients of invertebrate immunocytes, especially of insect hemocytes, the effector cells of insect immunity...
  22. Ishii K, Adachi T, Imamura K, Takano S, Usui K, Suzuki K, et al. Serratia marcescens induces apoptotic cell death in host immune cells via a lipopolysaccharide- and flagella-dependent mechanism. J Biol Chem. 2012;287:36582-92 pubmed publisher
    ..activation of c-Jun NH(2)-terminal kinase (JNK), followed by caspase activation and apoptosis of blood cells (hemocytes)...
  23. Yao C, Somero G. The impact of acute temperature stress on hemocytes of invasive and native mussels (Mytilus galloprovincialis and Mytilus californianus): DNA damage, membrane integrity, apoptosis and signaling pathways. J Exp Biol. 2012;215:4267-77 pubmed publisher
    ..and single-stranded DNA breakage, and signaling mechanisms involved in cellular homeostasis and apoptosis in hemocytes of native and invasive mussels, Mytilus californianus and Mytilus galloprovincialis, respectively...
  24. Kurz S, Jin C, Hykollari A, Gregorich D, Giomarelli B, Vasta G, et al. Hemocytes and plasma of the eastern oyster (Crassostrea virginica) display a diverse repertoire of sulfated and blood group A-modified N-glycans. J Biol Chem. 2013;288:24410-28 pubmed publisher
    ..In this study, we examined the N-glycans of both the hemocytes, which via CvGal1 are the target of the parasite, and the plasma of the oyster...
  25. Katsumiti A, Gilliland D, Arostegui I, Cajaraville M. Cytotoxicity and cellular mechanisms involved in the toxicity of CdS quantum dots in hemocytes and gill cells of the mussel Mytilus galloprovincialis. Aquat Toxicol. 2014;153:39-52 pubmed publisher
    ..mg Cd/L) was screened using neutral red (NR) and thiazolyl blue tetrazolium bromide (MTT) assays in isolated hemocytes and gill cells of mussels (Mytilus galloprovincialis)...
  26. Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, et al. Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. J Immunol. 2009;183:7451-60 pubmed publisher
    ..We searched for the Staphylococcus aureus genes required for phagocytosis by Drosophila hemocytes in a screening of mutant strains with defects in the structure of the cell wall...
  27. Fang Q, Wang L, Zhu Y, Stanley D, Chen X, Hu C, et al. Pteromalus puparum venom impairs host cellular immune responses by decreasing expression of its scavenger receptor gene. Insect Biochem Mol Biol. 2011;41:852-62 pubmed publisher
    ..We infer from these findings that one mechanism of impairing P. rapae hemocytic immune reactions is by silencing expression of Pr-SR. ..
  28. Rosa R, Santini A, Fievet J, Bulet P, Destoumieux Garzón D, Bachere E. Big defensins, a diverse family of antimicrobial peptides that follows different patterns of expression in hemocytes of the oyster Crassostrea gigas. PLoS ONE. 2011;6:e25594 pubmed publisher
    ..While big defensin sequences have been reported in various mollusk species, few studies have been devoted to their sequence diversity, gene organization and their expression in response to microbial infections...
  29. Haberkorn H, Lambert C, Le Goïc N, Guéguen M, Moal J, Palacios E, et al. Effects of Alexandrium minutum exposure upon physiological and hematological variables of diploid and triploid oysters, Crassostrea gigas. Aquat Toxicol. 2010;97:96-108 pubmed publisher
    ..Significant differences, in terms of phenoloxidase activity (PO) and reactive oxygen species (ROS) production of hemocytes, were observed between A. minutum-exposed and non-exposed oysters...
  30. Manachini B, Arizza V, Parrinello D, Parrinello N. Hemocytes of Rhynchophorus ferrugineus (Olivier) (Coleoptera: Curculionidae) and their response to Saccharomyces cerevisiae and Bacillus thuringiensis. J Invertebr Pathol. 2011;106:360-5 pubmed publisher
    ..Thus investigations into the natural defences of this curculionid are advisable. RPW hemocytes, the main immunocompetent cells in the insect, are described for the first time...
  31. Kong P, Zhang H, Wang L, Zhou Z, Yang J, Zhang Y, et al. AiC1qDC-1, a novel gC1q-domain-containing protein from bay scallop Argopecten irradians with fungi agglutinating activity. Dev Comp Immunol. 2010;34:837-46 pubmed publisher
    ..detected in the tissue of hepatopancreas and also marginally detectable in adductor, heart, mantle, gill and hemocytes by fluorescent quantitative real-time PCR...
  32. Gueguen Y, Bernard R, Julie F, Paulina S, Delphine D, Franck V, et al. Oyster hemocytes express a proline-rich peptide displaying synergistic antimicrobial activity with a defensin. Mol Immunol. 2009;46:516-22 pubmed publisher
    ..By in situ hybridization, the expression of Cg-prp was found to be restricted to hemocytes and induced following bacterial challenge...
  33. Munari M, Matozzo V, Marin M. Combined effects of temperature and salinity on functional responses of haemocytes and survival in air of the clam Ruditapes philippinarum. Fish Shellfish Immunol. 2011;30:1024-30 pubmed publisher
    ..philippinarum, and suggested a better physiological condition for animals kept at 15 °C temperature and 18 psu salinity. ..
  34. Nappi A, Poirie M, Carton Y. The role of melanization and cytotoxic by-products in the cellular immune responses of Drosophila against parasitic wasps. Adv Parasitol. 2009;70:99-121 pubmed publisher
    ..of large foreign objects within melanotic capsules comprised of several layers of adhering blood cells or hemocytes. This reaction is manifested by various Drosophila hosts in response to infection by endoparasitic wasps (i.e...
  35. Rodríguez Ramos T, Carpio Y, Bolivar J, Espinosa G, Hernández López J, Gollas Galván T, et al. An inducible nitric oxide synthase (NOS) is expressed in hemocytes of the spiny lobster Panulirus argus: cloning, characterization and expression analysis. Fish Shellfish Immunol. 2010;29:469-79 pubmed publisher
    ..A NOS full-length DNA was isolated from hemocytes by reverse transcription-polymerase chain reaction (RT-PCR) using degenerated primers...
  36. Le Grand F, Kraffe E, Marty Y, Donaghy L, Soudant P. Membrane phospholipid composition of hemocytes in the Pacific oyster Crassostrea gigas and the Manila clam Ruditapes philippinarum. Comp Biochem Physiol A Mol Integr Physiol. 2011;159:383-91 pubmed publisher
    ..NMI) FA and 20:1n-11, suggesting a functional significance of these PL molecular species in bivalve hemocytes. Lysoglycerophosphatidylcholine (LysoPC) levels were found to be fairly high in hemocytes, accounting for about ..
  37. Zhang S, Gunaratna R, Zhang X, Najar F, Wang Y, Roe B, et al. Pyrosequencing-based expression profiling and identification of differentially regulated genes from Manduca sexta, a lepidopteran model insect. Insect Biochem Mol Biol. 2011;41:733-46 pubmed publisher
    ..We obtained 1,821,652 reads with an average length of 289 bp per read from fat body and hemocytes of naïve and microbe-injected M. sexta larvae. After almost all (92...
  38. Ho P, Cheng C, Cheng W. Identification and cloning of the alpha2-macroglobulin of giant freshwater prawn Macrobrachium rosenbergii and its expression in relation with the molt stage and bacteria injection. Fish Shellfish Immunol. 2009;26:459-66 pubmed
    ..rosenbergii significantly increased at 24 h and 12 h after injection with heat-killed Lactococcus garvieae and Vibrio alginolyticus, respectively, which indicates that alpha2M is involved in the immune response of prawn. ..
  39. Hégaret H, da Silva P, Wikfors G, Haberkorn H, Shumway S, Soudant P. In vitro interactions between several species of harmful algae and haemocytes of bivalve molluscs. Cell Biol Toxicol. 2011;27:249-66 pubmed publisher
  40. Jeffroy F, Paillard C. Involvement of nitric oxide in the in vitro interaction between Manila clam, Ruditapes philippinarum, hemocytes and the bacterium Vibrio tapetis. Fish Shellfish Immunol. 2011;31:1137-41 pubmed publisher
    ..NO is a toxic agent to pathogens produced mostly by immune cells such as hemocytes in invertebrates...
  41. Xu W, Faisal M. Identification of the molecules involved in zebra mussel (Dreissena polymorpha) hemocytes host defense. Comp Biochem Physiol B Biochem Mol Biol. 2009;154:143-9 pubmed publisher
    ..This SSH-cDNA library was produced by using a cDNA library of naïve hemocytes as the driver and a cDNA library of hemocytes stimulated with a mixture of microbial antigens namely, ..
  42. Gestal C, Pallavicini A, Venier P, Novoa B, Figueras A. MgC1q, a novel C1q-domain-containing protein involved in the immune response of Mytilus galloprovincialis. Dev Comp Immunol. 2010;34:926-34 pubmed publisher
    ..Measurable transcript levels were also evident in all analyzed tissues of naïve adult mussels, and the hemocytes showed the highest expression levels...
  43. Li C, Song Y. Proline-rich domain of penaeidin molecule exhibits autocrine feature by attracting penaeidin-positive granulocytes toward the wound-induced inflammatory site. Fish Shellfish Immunol. 2010;29:1044-52 pubmed publisher
    ..Both penaeidin transcript and protein decreased in peripheral hemocytes but increased in the wound tissue...
  44. Martin Diaz L, Franzellitti S, Buratti S, Valbonesi P, Capuzzo A, Fabbri E. Effects of environmental concentrations of the antiepilectic drug carbamazepine on biomarkers and cAMP-mediated cell signaling in the mussel Mytilus galloprovincialis. Aquat Toxicol. 2009;94:177-85 pubmed publisher
    ..Our data indicate that CBZ, at concentrations found in the environment, affects the Mediterranean mussel by acting on specific biochemical pathways that are evolutionarily conserved. ..
  45. Gao H, Wu X, Fossett N. Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potency. Mol Cell Biol. 2009;29:6086-96 pubmed publisher
  46. Lima C, Torquato R, Sasaki S, Justo G, Tanaka A. Biochemical characterization of a Kunitz type inhibitor similar to dendrotoxins produced by Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) hemocytes. Vet Parasitol. 2010;167:279-87 pubmed publisher
    ..2pM). The BmCI gene expression analysis by semi-quantitative RT-PCR indicated its transcription in the hemocytes, salivary gland and ovary...
  47. Heath Heckman E, McFall Ngai M. The occurrence of chitin in the hemocytes of invertebrates. Zoology (Jena). 2011;114:191-8 pubmed publisher
    ..revealed that the only cells in contact with the symbionts that labeled with the probe were the macrophage-like hemocytes, which traffic into the light-organ crypts where the bacteria reside...
  48. Ciacci C, Betti M, Canonico B, Citterio B, Roch P, Canesi L. Specificity of anti-Vibrio immune response through p38 MAPK and PKC activation in the hemocytes of the mussel Mytilus galloprovincialis. J Invertebr Pathol. 2010;105:49-55 pubmed publisher
    In mussel (Mytilus sp.) hemocytes, differential functional responses to injection with different types of live and heat-killed Vibrio species have been recently demonstrated...
  49. Provost B, Jouan V, Hilliou F, Delobel P, Bernardo P, Ravallec M, et al. Lepidopteran transcriptome analysis following infection by phylogenetically unrelated polydnaviruses highlights differential and common responses. Insect Biochem Mol Biol. 2011;41:582-91 pubmed publisher
    ..didymator and M. demolitor. ..
  50. Sperstad S, Haug T, Paulsen V, Rode T, Strandskog G, Solem S, et al. Characterization of crustins from the hemocytes of the spider crab, Hyas araneus, and the red king crab, Paralithodes camtschaticus. Dev Comp Immunol. 2009;33:583-91 pubmed publisher
    ..In this study, two crustin isoforms from Hyas araneus hemocytes were purified and tested for antimicrobial activity against selected microorganisms...
  51. Galinier R, Roger E, Sautiere P, Aumelas A, Banaigs B, Mitta G. Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa. J Pept Sci. 2009;15:48-55 pubmed publisher
    ..two taxa (tunicates and echinoderms) for the presence of cationic antimicrobial peptides (AMP) in defence cells (hemocytes)...
  52. Sinenko S, Mandal L, Martinez Agosto J, Banerjee U. Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. Dev Cell. 2009;16:756-63 pubmed publisher
  53. Zhang Y, Song L, Zhao J, Wang L, Kong P, Liu L, et al. Protective immunity induced by CpG ODNs against white spot syndrome virus (WSSV) via intermediation of virus replication indirectly in Litopenaeus vannamei. Dev Comp Immunol. 2010;34:418-24 pubmed publisher
    ..vannamei...
  54. Fallon J, Reeves E, Kavanagh K. The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes. Microbiology. 2011;157:1481-8 pubmed publisher
    ..During growth of the fungus in the larvae, this toxin, along with others, may facilitate growth by suppressing the cellular immune response. ..
  55. Oliver J, Dusty Loy J, Parikh G, Bartholomay L. Comparative analysis of hemocyte phagocytosis between six species of arthropods as measured by flow cytometry. J Invertebr Pathol. 2011;108:126-30 pubmed publisher
    Phagocytosis of pathogens by hemocytes is a rapid-acting immune response and represents a primary means of limiting microbial infection in some species of arthropods...
  56. Nyholm S, Stewart J, Ruby E, McFall Ngai M. Recognition between symbiotic Vibrio fischeri and the haemocytes of Euprymna scolopes. Environ Microbiol. 2009;11:483-93 pubmed publisher
    ..These data suggest that regulation of host haemocyte binding by the symbiont may be one of many factors that contribute to specificity in this association. ..
  57. Li H, Venier P, Prado Alvarez M, Gestal C, Toubiana M, Quartesan R, et al. Expression of Mytilus immune genes in response to experimental challenges varied according to the site of collection. Fish Shellfish Immunol. 2010;28:640-8 pubmed publisher
    ..We confirmed that the 5 genes are constitutively expressed in hemocytes, defensin being the less expressed, myticin B the highest...
  58. Honti V, Csordás G, Márkus R, Kurucz E, Jankovics F, Ando I. Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster. Mol Immunol. 2010;47:1997-2004 pubmed publisher
  59. Chevalier F, Herbinière Gaboreau J, Bertaux J, Raimond M, Morel F, Bouchon D, et al. The immune cellular effectors of terrestrial isopod Armadillidium vulgare: meeting with their invaders, Wolbachia. PLoS ONE. 2011;6:e18531 pubmed publisher
    ..In contrast with insect models, the isopod Armadillidium vulgare is known to harbor Wolbachia inside the haemocytes...
  60. Gonzalez Riopedre M, Barcia R, Ramos Martínez J. The Ca2+-independent PKC (p105) mediates the PMA-activation of marine mussel hemocytes and the Ca2+-dependent PKC (p60) does not intervene. Mol Cell Biochem. 2009;332:243-9 pubmed publisher
    ..shows a balance between cytosolic and membrane fractions in mantle, gills, and hepatopancreas, whereas, in hemocytes, their expression is mainly cytosolic, as happens in muscle tissues with p60 alone...
  61. HILLYER J, Estévez Lao T. Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria. Dev Comp Immunol. 2010;34:141-9 pubmed publisher
    ..Quantitative PCR and Western blot analyses showed that nitric oxide synthase is expressed in hemocytes and fat body, and is upregulated in response to systemic infection with Escherichia coli and Micrococcus luteus...
  62. Prado Alvarez M, Gestal C, Novoa B, Figueras A. Differentially expressed genes of the carpet shell clam Ruditapes decussatus against Perkinsus olseni. Fish Shellfish Immunol. 2009;26:72-83 pubmed publisher
    ..The complete open reading frames of selected sequences (Rd adiponectin-C1q and Rd DAD-1) were determined. Our results provide new insights into the molecular basis of host-pathogen interactions in R. decussatus. ..
  63. Cronin S, Nehme N, Limmer S, Liegeois S, Pospisilik J, Schramek D, et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 2009;325:340-3 pubmed publisher
    ..We first employed whole-organism gene suppression, followed by tissue-specific silencing in gut epithelium or hemocytes to identify several hundred genes involved in intestinal antibacterial immunity...
  64. Costa A, Jan E, Sarnow P, Schneider D. The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS ONE. 2009;4:e7436 pubmed publisher
    ..we injected wild type flies with CrPV and observed that antimicrobial peptides (AMPs) were not induced and hemocytes were depleted in the course of infection...
  65. Evans I, Wood W. Understanding in vivo blood cell migration--Drosophila hemocytes lead the way. Fly (Austin). 2011;5:110-4 pubmed
    Drosophila embryonic hemocytes have emerged as a potent system to analyze the roles of key regulators of the actin and microtubule cytoskeletons live and in an in vivo context (see Table I and references therein)...
  66. Grigorian M, Mandal L, Hartenstein V. Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland. Dev Genes Evol. 2011;221:121-31 pubmed publisher
    ..Differentiation into two types of hemocytes, plasmatocytes and crystal cells, is confined to the outer layer (cortical zone) of the primary lobe; the center ..
  67. Arenas G, Guzman F, Cárdenas C, Mercado L, Marshall S. A novel antifungal peptide designed from the primary structure of a natural antimicrobial peptide purified from Argopecten purpuratus hemocytes. Peptides. 2009;30:1405-11 pubmed publisher
    We have isolated and purified a natural antimicrobial peptide from Argopecten purpuratus hemocytes. 47 residues were determined from its primary structure representing the N-terminal of the complete sequence. This peptide of 5100...
  68. Baton L, Robertson A, Warr E, Strand M, Dimopoulos G. Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection. BMC Genomics. 2009;10:257 pubmed publisher
    ..The mosquito Anopheles gambiae is a major vector of human malaria. Increasing evidence indicates that blood cells (hemocytes) comprise an essential arm of the mosquito innate immune response against both bacteria and malaria parasites...
  69. Matozzo V, Marin M. The role of haemocytes from the crab Carcinus aestuarii (Crustacea, Decapoda) in immune responses: A first survey. Fish Shellfish Immunol. 2010;28:534-41 pubmed publisher
    ..aestuarii haemocytes are not very active phagocytic cells, but they are more active in terms of both hydrolytic and oxidative enzyme activities and superoxide anion production. ..
  70. Gerdol M, Manfrin C, De Moro G, Figueras A, Novoa B, Venier P, et al. The C1q domain containing proteins of the Mediterranean mussel Mytilus galloprovincialis: a widespread and diverse family of immune-related molecules. Dev Comp Immunol. 2011;35:635-43 pubmed publisher
  71. Ciacci C, Barmo C, Fabbri R, Canonico B, Gallo G, Canesi L. Immunomodulation in Mytilus galloprovincialis by non-toxic doses of hexavalent chromium. Fish Shellfish Immunol. 2011;31:1026-33 pubmed publisher
    ..Overall, the results indicate that exposure to non-toxic, environmentally relevant concentrations of Cr(VI) can modulate functional and molecular immune parameters in M. galloprovincialis. ..
  72. Bettencourt R, Dando P, Collins P, Costa V, Allam B, Serrão Santos R. Innate immunity in the deep sea hydrothermal vent mussel Bathymodiolus azoricus. Comp Biochem Physiol A Mol Integr Physiol. 2009;152:278-89 pubmed publisher
    ..in the hemolymph and extrapallial fluid were examined and led to the identification of three types of hemocytes revealing the granulocytes as the most abundant type of cell...
  73. Green T, Dixon T, Devic E, Adlard R, Barnes A. Differential expression of genes encoding anti-oxidant enzymes in Sydney rock oysters, Saccostrea glomerata (Gould) selected for disease resistance. Fish Shellfish Immunol. 2009;26:799-810 pubmed publisher
    ..glomerata hemocytes were identified using the PCR technique, suppression subtractive hybridisation (SSH)...
  74. Costa M, Prado Alvarez M, Gestal C, Li H, Roch P, Novoa B, et al. Functional and molecular immune response of Mediterranean mussel (Mytilus galloprovincialis) haemocytes against pathogen-associated molecular patterns and bacteria. Fish Shellfish Immunol. 2009;26:515-23 pubmed
    ..The differences between M. lysodeikticus and V. anguillarum in different measured parameters may suggest that different signalling pathways might be involved. Moreover, among all assayed PAMPs, LPS elicited the highest response. ..
  75. Bina S, Wright V, Fisher K, Milo M, Zeidler M. Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. EMBO Rep. 2010;11:201-7 pubmed publisher
    ..Such an inter-species approach is an effective way to identify factors with conserved functions that might be central to human disease. ..
  76. Trevisan R, Arl M, Sacchet C, Engel C, Danielli N, Mello D, et al. Antioxidant deficit in gills of Pacific oyster (Crassostrea gigas) exposed to chlorodinitrobenzene increases menadione toxicity. Aquat Toxicol. 2012;108:85-93 pubmed publisher
    ..After showing that CDNB decreased gill antioxidant defenses and increased DNA damage in hemocytes, oysters were further challenged with 1 mM MEN over 24 h...
  77. Pastor Pareja J, Wu M, Xu T. An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech. 2008;1:144-54; discussion 153 pubmed publisher
    ..We found that circulating blood cells, termed hemocytes, adhere to tumors upon detection of basement membrane disruption, and subsequently counter their growth...
  78. Dushay M. Insect hemolymph clotting. Cell Mol Life Sci. 2009;66:2643-50 pubmed publisher
    ..The few similarities between coagulation in different insect species and life stages, and the current state of knowledge about coagulation in insects are discussed. ..
  79. Charoensapsri W, Amparyup P, Hirono I, Aoki T, Tassanakajon A. Gene silencing of a prophenoloxidase activating enzyme in the shrimp, Penaeus monodon, increases susceptibility to Vibrio harveyi infection. Dev Comp Immunol. 2009;33:811-20 pubmed publisher
    ..PmPPAE1 mRNA is abundantly expressed in hemocytes, and this is regulated after systemic Vibrio harveyi infection supporting that it is an immune-responsive gene...
  80. Yang J, Qiu L, Wei X, Wang L, Wang L, Zhou Z, et al. An ancient C-type lectin in Chlamys farreri (CfLec-2) that mediate pathogen recognition and cellular adhesion. Dev Comp Immunol. 2010;34:1274-82 pubmed publisher
    ..The mRNA expression of CfLec-2 in hemocytes was significantly up-regulated (P<0...
  81. Akbar M, Tracy C, Kahr W, KRAMER H. The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila. J Cell Biol. 2011;192:383-90 pubmed publisher
    ..fob hemocytes (fly macrophages) engulf bacteria but fail to digest them...
  82. Huang F, Shi M, Yang Y, Li J, Chen X. Changes in hemocytes of Plutella xylostella after parasitism by Diadegma semiclausum. Arch Insect Biochem Physiol. 2009;70:177-87 pubmed publisher
    We examined the changes of hemocytes in the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae), due to parasitism by the endoparasitoid Diadegma semiclausum (Hymenoptera: Ichneumonidae)...
  83. Pinto S, Lombardo F, Koutsos A, Waterhouse R, McKay K, An C, et al. Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae. Proc Natl Acad Sci U S A. 2009;106:21270-5 pubmed publisher
    Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation and also secrete immune factors such as opsonins, melanization factors, and antimicrobial peptides...
  84. Filipiak M, Bilska E, Tylko G, Pyza E. Effects of zinc on programmed cell death of Musca domestica and Drosophila melanogaster blood cells. J Insect Physiol. 2010;56:383-90 pubmed publisher
    ..influence of Zn(2+), an important element to fundamental biological processes, on phagocytosis and apoptosis of hemocytes in two fly species: Musca domestica and Drosophila melanogaster...
  85. Ulvila J, Vanha aho L, Ramet M. Drosophila phagocytosis - still many unknowns under the surface. APMIS. 2011;119:651-62 pubmed publisher
    ..This review summarizes the current knowledge on Drosophila phagocytosis focusing on the most recent advancements in the field, and highlighting the benefits the Drosophila system has to offer for research on phagocytosis. ..
  86. Charroux B, Royet J. Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response. Proc Natl Acad Sci U S A. 2009;106:9797-802 pubmed publisher
    Drosophila hemocytes have strong phagocytic capacities and produce antimicrobial peptides (AMPs). However, the precise role of blood cells during immune responses and developmental processes has only been studied using indirect means...
  87. Laughton A, Garcia J, Altincicek B, Strand M, Gerardo N. Characterisation of immune responses in the pea aphid, Acyrthosiphon pisum. J Insect Physiol. 2011;57:830-9 pubmed publisher
    ..We discuss these results in relation to recent findings from the pea aphid genome annotation project that suggest that aphids have a reduced immune gene repertoire compared to other insects...
  88. Mattos A, Martins Souza R, Kusel J, Coelho P. Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite. Mem Inst Oswaldo Cruz. 2011;106:424-32 pubmed
    ..tenagophila IDS cannot be confirmed by the transplantation experiments. These data suggest that there are additional mechanisms involved in the lower susceptibilty of B. tenagophila to S. mansoni infection...
  89. Martins Souza R, Pereira C, Coelho P, Martins Filho O, Negrão Corrêa D. Flow cytometry analysis of the circulating haemocytes from Biomphalaria glabrata and Biomphalaria tenagophila following Schistosoma mansoni infection. Parasitology. 2009;136:67-76 pubmed publisher
    ..mansoni infection, suggesting that this cell subset would participate in the early parasite destruction observed in this snail strain...
  90. Li C, Yan H, Song Y. Tiger shrimp (Penaeus monodon) penaeidin possesses cytokine features to promote integrin-mediated granulocyte and semi-granulocyte adhesion. Fish Shellfish Immunol. 2010;28:1-9 pubmed publisher
    ..To study immunomodulation functions of the penaeidin, we transfected shrimp hemocytes in primary culture with penaeidin-specific small interfering RNA (siRNA-3) and observed a concomitant 20% ..
  91. Perazzolo L, Bachere E, Rosa R, Goncalves P, Andreatta E, Daffre S, et al. Alpha2-macroglobulin from an Atlantic shrimp: biochemical characterization, sub-cellular localization and gene expression upon fungal challenge. Fish Shellfish Immunol. 2011;31:938-43 pubmed publisher
    ..paulensis is stored in the vesicles of the shrimp granular hemocytes (through immunogold assay)...
  92. Tokusumi T, Shoue D, Tokusumi Y, Stoller J, Schulz R. New hemocyte-specific enhancer-reporter transgenes for the analysis of hematopoiesis in Drosophila. Genesis. 2009;47:771-4 pubmed publisher
    ..While this work focused on the hematopoietic process, these new vectors can be used to mark multiple cell types or trace complex cell lineages during any chosen aspect of Drosophila development...