heinz bodies


Summary: Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.

Top Publications

  1. Moenner M, Vosoghi M, Ryazantsev S, Glitz D. Ribonuclease inhibitor protein of human erythrocytes: characterization, loss of activity in response to oxidative stress, and association with Heinz bodies. Blood Cells Mol Dis. 1998;24:149-64 pubmed
    ..and a gradual and irreversible loss of inhibitor activity; inhibitor disappeared from the cytosol and became associated with nascent Heinz bodies. We suggest a role for this protein in the metabolism and aging process of the erythrocyte.
  2. Potter W, Rong S, Griffith J, White J, Garry V. Phosphine-mediated Heinz body formation and hemoglobin oxidation in human erythrocytes. Toxicol Lett. 1991;57:37-45 pubmed
    ..demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreversible hemichrome formation...
  3. Chu L, Ebersole J, Holt S. Hemoxidation and binding of the 46-kDa cystalysin of Treponema denticola leads to a cysteine-dependent hemolysis of human erythrocytes. Oral Microbiol Immunol. 1999;14:293-303 pubmed
    ..the hemoxidative events, the hemoglobin molecule associated with the red blood cell membrane, forming putative Heinz bodies. Spectrophotometric analysis of the hemoxidative events (cystalysin + cysteine + red blood cells) revealed a ..
  4. Allison R, Lassen E, Burkhard M, Lappin M. Effect of a bioflavonoid dietary supplement on acetaminophen-induced oxidative injury to feline erythrocytes. J Am Vet Med Assoc. 2000;217:1157-61 pubmed
    ..Packed cell volume, percentage of erythrocytes with Heinz bodies, blood methemoglobin concentration, and blood reduced and oxidized glutathione concentrations were determined ..
  5. Weiss D, McClay C, Christopher M, Murphy M, Perman V. Effects of propylene glycol-containing diets on acetaminophen-induced methemoglobinemia in cats. J Am Vet Med Assoc. 1990;196:1816-9 pubmed
    ..3% PG. All cats on the PG diet developed an increase in the number of circulating Heinz bodies. We then administered acetaminophen to cats on each diet to determine whether RBC from cats on PG diets were ..
  6. Thompson J, Pauli J, Hopcroft D, Bell G. An unusual Heinz body anaemia in a cat. J Comp Pathol. 1989;100:343-7 pubmed
    A severe anaemia was diagnosed in a 7-month-old female cat. Most erythrocytes contained unusually large Heinz bodies and showed marked distortion...
  7. Pearson W, Boermans H, Bettger W, McBride B, Lindinger M. Association of maximum voluntary dietary intake of freeze-dried garlic with Heinz body anemia in horses. Am J Vet Res. 2005;66:457-65 pubmed
    ..samples were collected weekly and analyzed for hematologic and biochemical changes, including the presence of Heinz bodies. Recovery of affected blood values was followed for 5 weeks after termination of dietary supplementation with ..
  8. Christopher M, Broussard J, Peterson M. Heinz body formation associated with ketoacidosis in diabetic cats. J Vet Intern Med. 1995;9:24-31 pubmed
    ..b>Heinz bodies also contribute to anemia...
  9. Goto I, Agar N, Maede Y. Relation between reduced glutathione content and Heinz body formation in sheep erythrocytes. Am J Vet Res. 1993;54:622-6 pubmed
    ..The formation of Heinz bodies in low-GSH cells was higher than that in high-GSH cells when the cells were incubated with an oxidant drug, ..

More Information

Publications123 found, 100 shown here

  1. Prchal J, Adler B, Wilson J, Baysal E, Qin W, Molchanova T, et al. Hb Bibba or alpha 2 136(H19)Leu-->Pro beta 2 in a Caucasian family from Alabama. Hemoglobin. 1995;19:151-64 pubmed
    ..The first Hb Bibba heterozygote, characterized in 1968 (1), is believed to be a member of this family. The clinical expression of the disease is surprisingly variable. ..
  2. Smith C, Berkseth R. Sensitivity of erythrocytes to oxidant stress in uremia. Am J Nephrol. 1990;10:61-8 pubmed
    The erythrocytes from 19 chronic hemodialysis patients were examined for Heinz bodies and their sensitivity to oxidant stress. Heinz bodies were found in 63% of patients and an elevated level of oxidized hemoglobin in 36%...
  3. Bursian S, Alexander C, Cacela D, Cunningham F, Dean K, Dorr B, et al. Reprint of: Overview of avian toxicity studies for the Deepwater Horizon Natural Resource Damage Assessment. Ecotoxicol Environ Saf. 2017;146:4-10 pubmed publisher
    ..Results of these studies indicated changes in hematologic endpoints including formation of Heinz bodies and changes in cell counts...
  4. Harr K, Cunningham F, Pritsos C, Pritsos K, Muthumalage T, Dorr B, et al. Weathered MC252 crude oil-induced anemia and abnormal erythroid morphology in double-crested cormorants (Phalacrocorax auritus) with light microscopic and ultrastructural description of Heinz bodies. Ecotoxicol Environ Saf. 2017;146:29-39 pubmed publisher
    ..One reported effect was hemolytic anemia with the presence of Heinz bodies (HB) in birds, however, the role of route and magnitude of exposure to oil is unknown...
  5. Ciechanowski K, Bober J, Ciechanowska B, Machoy Z. [Superoxide dismutase activity of erythrocytes and their osmotic fragility]. Pol Arch Med Wewn. 1992;88:209-11 pubmed
    ..Erythrocyte superoxide dismutase activity, Heinz bodies and osmotic fragility were determined...
  6. Nagel R, Ranney H, Bradley T, Jacobs A, Udem L. Hemoglobin L Ferrara in a Jewish family associated with a hemolytic state in the propositus. Blood. 1969;34:157-65 pubmed
  7. Jennifer H, Mariana P, Karyn B. Serotonin Syndrome from 5-Hydroxytryptophan Supplement Ingestion in a 9-Month-Old Labrador Retriever. J Med Toxicol. 2017;13:183-186 pubmed publisher
    ..A hemogram revealed mild anemia with evidence of oxidative erythrocyte damage (eccentrocytes, Heinz bodies, and siderocytes)...
  8. Gutzwiller A. [The effect of the selenium status of goats on the resistance of erythrocytes to oxidative damage]. Schweiz Arch Tierheilkd. 1991;133:157-61 pubmed
    ..Erythrocytes with Heinz bodies appeared within one week after increasing the DMDS dose to 50 mg/kg/day and reached a peak one week later (30% ..
  9. Munday R, Smith B, Munday C. Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats. Chem Biol Interact. 1998;108:155-70 pubmed
    ..Dicoumarol increased the severity of menadione-induced haemolytic anaemia while BHA decreased it, consistent with a role for DT-diaphorase in the detoxification of menadione in vivo, as previously described in vitro. ..
  10. Mojzikova R, Dolezel P, Pavlicek J, Mlejnek P, Pospisilova D, Divoky V. Partial glutathione reductase deficiency as a cause of diverse clinical manifestations in a family with unstable hemoglobin (Hemoglobin HanĂ¡, ?63(E7) His-Asn). Blood Cells Mol Dis. 2010;45:219-22 pubmed publisher
    ..This study provides evidence that partial GR deficiency may alter the clinical manifestation of an unstable hemoglobinopathy. ..
  11. Nakamura T, Hasegawa S, Shio H, Uyesaka N. Rheologic and pathophysiologic significance of red cell passage through narrow pores. Blood Cells. 1994;20:151-65; discussion 166-8 pubmed
    ..Thus, 3-micron-filtration measurements may contribute to several subfields of hematology. ..
  12. Fallin C, Christopher M. In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. Am J Vet Res. 1996;57:463-7 pubmed
    ..were incubated with various concentrations of ketone bodies and tested at defined time intervals for Heinz bodies, GSH concentration, and D- and L-lactate production. Three healthy female domestic cats...
  13. Lee K, Yamato O, Tajima M, Kuraoka M, Omae S, Maede Y. Hematologic changes associated with the appearance of eccentrocytes after intragastric administration of garlic extract to dogs. Am J Vet Res. 2000;61:1446-50 pubmed
    ..and methemoglobin and erythrocyte-reduced glutathione concentrations, percentage of erythrocytes with Heinz bodies, and percentage of eccentrocytes were determined before and for 30 days after administration of the first dose ..
  14. Fukushima Y, Kon H. On the mechanism of loss of deformability in human erythrocytes due to Heinz body formation: a flow EPR study. Toxicol Appl Pharmacol. 1990;102:205-18 pubmed
    ..The decrease in deformability starts even before Heinz body formation is recognized and is enhanced with PHZ as Heinz bodies are attached on the inner surface of the membrane, but remains at a low level in MMH-treated cells in which ..
  15. Bexfield N, Archer J, Herrtage M. Heinz body haemolytic anaemia in a dog secondary to ingestion of a zinc toy: a case report. Vet J. 2007;174:414-7 pubmed
    ..Clinical examination revealed pale mucous membranes and jaundice. Haematology demonstrated large numbers of Heinz bodies and a marked anaemia, which was strongly regenerative. Serum zinc concentrations were markedly elevated...
  16. Lee T, Kim S, Yu S, Kim S, Park D, Moon H, et al. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood. 2003;101:5033-8 pubmed
    ..However, they had splenomegaly caused by the congestion of red pulp with hemosiderin accumulation. Heinz bodies were detected in their peripheral blood, and morphologically abnormal cells were elevated in the dense red ..
  17. Lachant N, Tanaka K. Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria?. Am J Hematol. 1987;26:211-9 pubmed
    ..Thus impaired antioxidant defense may account for the persistence of the hemoglobin E gene in areas where malaria is endemic. Oxidant medications should be used with caution in individuals of Southeast Asian origin. ..
  18. Papassotiriou I, Traeger Synodinos J, Prome D, Kister J, Vrettou C, Xaidara A, et al. Hb Sitia [beta128(H6)Ala-->Val]: an unstable variant with a substitution in the alpha1beta1 interface. Hemoglobin. 2001;25:45-56 pubmed
    ..Since alanine at beta128(H6) interacts with several amino acids of the alpha1beta1 contact, its replacement by a larger residue results in a mild instability of the molecule and slight modifications of the oxygen binding properties. ..
  19. Chaves M, Leonart M, do Nascimento A. Oxidative process in erythrocytes of individuals with hemoglobin S. Hematology. 2008;13:187-92 pubmed publisher
    ..degradation of the hemoglobin S due to its deoxigenation leading to hemichrome formation and precipitation as Heinz bodies. The oxidative stress contributes to the sickle process and shortening of the erythrocyte survival...
  20. Linss W, Halbhuber K, Werner J, Zimmermann N, Meyer H. [Does induced Heinz body formation lead to the liberation of IgG receptors on the erythrocyte membrane?]. Acta Histochem Suppl. 1990;39:423-34 pubmed
    ..microscopical and biochemical studies led other authors to the conclusion that the formation of membrane-bound Heinz bodies at these parts of the plasmalemma of erythrocytes leads to clustering of band 3-protein and increased binding ..
  21. Hinchliffe R. Errors in automated reticulocyte counts due to Heinz bodies. J Clin Pathol. 1993;46:878-9 pubmed
    ..Serial reticulocyte counts on a patient with an unstable haemoglobin haemolytic anaemia whose red cells contained Heinz bodies were obtained by two automated methods...
  22. Platt O, Falcone J. Membrane protein lesions in erythrocytes with Heinz bodies. J Clin Invest. 1988;82:1051-8 pubmed
  23. Luttgen P, Whitney M, Wolf A, Scruggs D. Heinz body hemolytic anemia associated with high plasma zinc concentration in a dog. J Am Vet Med Assoc. 1990;197:1347-50 pubmed
    ..of acute zinc toxicosis in dogs, with the exception of a history of generalized seizures and the findings of Heinz bodies. Although a causative relationship between plasma zinc values and Heinz body formation cannot be proven, their ..
  24. Ponte C, Lewis M, Rogers J. Heinz-body hemolytic anemia associated with phenazopyridine and sulfonamide. DICP. 1989;23:140-2 pubmed
    ..It is also important that the clinician recognize those drugs capable of causing this disorder and appreciate the methods available to establish the diagnosis. ..
  25. Ohba Y, Yamamoto K, Hattori Y, Kawata R, Miyaji T. Hyperunstable hemoglobin Toyama [alpha 2 136(H19)Leu----Arg beta 2]: detection and identification by in vitro biosynthesis with radioactive amino acids. Hemoglobin. 1987;11:539-56 pubmed
    ..The son, who also produced the abnormal alpha chain, was essentially free from hemolytic manifestation. His red cells were microcytic and showed an alpha/beta synthetic ratio of over 2. ..
  26. Sills M, Zinkham W. Methylene blue-induced Heinz body hemolytic anemia. Arch Pediatr Adolesc Med. 1994;148:306-10 pubmed
    ..anemia requiring transfusions, and red blood cell dysmorphology, including the appearance of blister cells and Heinz bodies visible in both Wright's- and supravital-stained peripheral blood smears...
  27. Ohno H, Tojo H, Kakihata K, Nomura M, Takayama S. Heinz body hemolytic anemia induced by DQ-2511, a new anti-ulcer drug, in dogs. Fundam Appl Toxicol. 1993;20:141-6 pubmed
    ..Hemolytic anemia accompanied by an increase in the number of cells containing Heinz bodies that was preceded by a marked decrease in blood-reduced glutathione concentration was observed in dogs ..
  28. Valenzise M, Ferrero G, Tosi M, Ferraris S, Silengo M. Mental retardation, peculiar facial dysmorphism and HbH inclusions in a 4-year-old boy. Eur J Pediatr. 2002;161:627-8 pubmed
  29. Zaks K, Tan E, Thrall M. Heinz body anemia in a dog that had been sprayed with skunk musk. J Am Vet Med Assoc. 2005;226:1516-8, 1500 pubmed
    ..Skunk interactions with dogs usually have malodorous but otherwise harmless results. However, findings in this dog suggest that more serious consequences may develop in isolated cases. ..
  30. Ankringa N, Wijnberg I, Boerma S, Ijzer J. Copper-associated hepatic cirrhosis in a Friesian horse. Tijdschr Diergeneeskd. 2012;137:310-4 pubmed
    ..Soon after diagnosis, the animal showed signs of intravascular haemolysis, with the presence of Heinz bodies in peripheral blood smears, and haemoglobinuria...
  31. Christopher M. Relation of endogenous Heinz bodies to disease and anemia in cats: 120 cases (1978-1987). J Am Vet Med Assoc. 1989;194:1089-95 pubmed
    ..variables were evaluated retrospectively in a population of feline patients with high number of circulating Heinz bodies. By comparing these cats with a control population and results of additional hematologic investigation on a ..
  32. Hasegawa S, Rodgers G, Shio H, Schechter A, Uyesaka N. Impaired deformability of Heinz body-forming red cells. Biorheology. 1993;30:275-86 pubmed
    ..RBCs) has been suspected in Heinz body-forming hemolytic anemia, it remains uncertain whether the formation of Heinz bodies themselves impairs RBC deformability or not...
  33. Hill A, O NEILL S, Rogers Q, Christopher M. Antioxidant prevention of Heinz body formation and oxidative injury in cats. Am J Vet Res. 2001;62:370-4 pubmed
    ..After 2 weeks, Heinz bodies were induced by dietary onion powder (OP; 1% or 3% of dry matter) or propylene glycol (PG, 8% wt/vol in ..
  34. Lacan P, Badens C, Lena Russo D, Merono F, Thuret I, Aubry M, et al. Hb aubagne [beta64(E8)Gly-Ala]: a new unstable beta chain variant found in a French family. Hemoglobin. 2002;26:163-7 pubmed
  35. Bucci T, Kovatch R, Mercieca M, Perman V, Klingensmith J. Two-generation reproductive study in mink fed diisopropyl methylphosphonate (DIMP). Reprod Toxicol. 2003;17:327-34 pubmed
    ..Plasma cholinesterase was reduced 40% (F0) and 31% (F1), as was whole blood cholinesterase (16 and 8.5%). Heinz bodies were present in 2.8% (F0) and 1.3% (F1) of erythrocytes. The erythrocyte count was reduced 6.3% in the F0...
  36. Bley C, Roos M, Price J, Ruess Melzer K, Buchholz J, Poirier V, et al. Clinical assessment of repeated propofol-associated anesthesia in cats. J Am Vet Med Assoc. 2007;231:1347-53 pubmed
    ..b>Heinz bodies were identified in low numbers in both groups during radiotherapy...
  37. Hickman M, Rogers Q, Morris J. Effect of diet on Heinz body formation in kittens. Am J Vet Res. 1990;51:475-8 pubmed
    ..All kittens fed PG developed Heinz bodies, with peak values for erythrocytes containing Heinz bodies being: 28% for kittens of the 10% PG group; 20% for ..
  38. Palasuwan A, Soogarun S, Wiwanitkit V, Luechapudiporn R, Pradniwat P, Lertlum T. Preliminary study of the effect of vitamin E supplementation on the antioxidant status of hemoglobin-E carriers. Southeast Asian J Trop Med Public Health. 2006;37 Suppl 3:184-9 pubmed
    ..This demonstrated that vitamin E 200 IU could be used as a lipophilic antioxidant in red blood cells and could help increase the level of antioxidant in hemoglobin-E carriers. ..
  39. Fallon J, Smith E, Schoch N, Paruk J, Adams E, Evers D, et al. Hematological indices of injury to lightly oiled birds from the Deepwater Horizon oil spill. Environ Toxicol Chem. 2018;37:451-461 pubmed publisher
    ..Erythrocytic inclusions consistent with Heinz bodies were present almost exclusively in birds from sites impacted with oil, a finding pathognomonic for oxidative ..
  40. Lachant N, Tanaka K. Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. Am J Med Sci. 1987;294:364-8 pubmed
    ..Given the influx of Southeast Asians into the United States, oxidant medications should be used with caution, especially if an infection is present, in individuals of ethnic backgrounds that have an increased prevalence of hemoglobin E. ..
  41. Suttle N, Jones D, Woolliams C, Woolliams J. Heinz body anaemia in lambs with deficiencies of copper or selenium. Br J Nutr. 1987;58:539-48 pubmed
    ..Cu had lower whole-blood haemoglobin (Hb) concentrations and a higher percentage of erythrocytes containing Heinz bodies (6.6 v. 3.7%, P less than 0...
  42. Bucci T, Wustenberg W, Perman V, Weiss D, Dacre J, Baumel I, et al. Subchronic oral toxicity study of diisopropyl methylphosphonate in mink. Fundam Appl Toxicol. 1994;22:220-30 pubmed
    ..Erythrocyte ChE was not reduced. Heinz bodies occurred in 10-15% of RBCs in 50% of 8000 ppm mink at 13 weeks, and 0.1-2.0% of RBCs in 25% at 2700 ppm...
  43. Yamato O, Hayashi M, Yamasaki M, Maede Y. Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphate. Vet Rec. 1998;142:216-9 pubmed
    ..In the affected dogs there was a 10-fold increase in the concentration of oxidised glutathione in their erythrocytes 12 hours after the administration of the compound, whereas in normal dogs there was almost no change...
  44. Dash S, Harano K, Menon S. Hb Sallanches [alpha104(G11)Cys-->Tyr, TGC-->TAC (alpha2)]: an unstable hemoglobin variant found in an Indian child. Hemoglobin. 2006;30:393-6 pubmed
  45. Alward A, Corriher C, Barton M, Sellon D, Blikslager A, Jones S. Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases. J Vet Intern Med. 2006;20:1197-201 pubmed
    ..This study suggests that information obtained on initial examination cannot be used to accurately predict survival in horses with red maple toxicosis, but horses that receive corticosteroids are unlikely to survive. ..
  46. Mathews S, Selvam R. Effect of radical treatment on erythrocyte lipid peroxidation in Plasmodium vivax-infected malaria patients. Biochem Int. 1991;25:211-20 pubmed
    ..Superoxide dismutase showed restoration of enzyme activity while catalase activity was increased significantly following therapy, suggesting an active involvement of free radical mechanism. ..
  47. Christopher M, Perman V, Eaton J. Contribution of propylene glycol-induced Heinz body formation to anemia in cats. J Am Vet Med Assoc. 1989;194:1045-56 pubmed
  48. Ballin A, Brown E, Koren G, Zipursky A. Vitamin C-induced erythrocyte damage in premature infants. J Pediatr. 1988;113:114-20 pubmed
    This study was undertaken after the observation in a premature infant of a hemolytic anemia with Heinz bodies that appeared to result from administration of a multivitamin preparation...
  49. Troisi G, Borjesson L, Bexton S, Robinson I. Biomarkers of polycyclic aromatic hydrocarbon (PAH)-associated hemolytic anemia in oiled wildlife. Environ Res. 2007;105:324-9 pubmed
    ..anemia via oxidative attack of erythrocytes by PAH metabolites resulting in hemoglobin leakage and formation of Heinz bodies. In such cases, haptoglobin and ferritin are up-regulated to sequester free Hb and iron in the circulation...
  50. Athanasiou G, Zoubos N, Missirlis Y. Erythrocyte membrane deformability in patients with thalassemia syndromes. Nouv Rev Fr Hematol. 1991;33:15-20 pubmed
    ..This modulus was compared with the one of the normal cells. Inclusions (Heinz bodies) were produced artificially in normal cells and their elastic shear modulus was also measured...
  51. Christopher M, White J, Eaton J. Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in cats. Vet Pathol. 1990;27:299-310 pubmed
    ..drug-induced and spontaneous Heinz body formation in cats, the cellular and biochemical mechanisms by which Heinz bodies result in red blood cell (RBC) destruction and hemolytic anemia in this species remain unknown...
  52. Jubb T, Jerrett I, Browning J, Thomas K. Haemoglobinuria and hypophosphataemia in postparturient dairy cows without dietary deficiency of phosphorus. Aust Vet J. 1990;67:86-9 pubmed
    ..Seven of 9 cows sampled were hypophosphataemic, 4 of 8 cows examined had Heinz bodies present in erythrocytes and strong ketonuria was present in 6 of 10 urine samples tested...
  53. Palasuwan A, Soogarun S, Lertlum T, Pradniwat P, Wiwanitkit V. Inhibition of Heinz body induction in an in vitro model and total antioxidant activity of medicinal Thai plants. Asian Pac J Cancer Prev. 2005;6:458-63 pubmed
    ..The antioxidant activities were investigated in two bioassays. Firstly, we demonstrated inhibition of Heinz bodies induction caused by oxidants under in vitro condition...
  54. McConnico R, Brownie C. The use of ascorbic acid in the treatment of 2 cases of red maple (Acer rubrum)-poisoned horses. Cornell Vet. 1992;82:293-300 pubmed
    ..Clinical recovery was dramatic with stabilization achieved 36 hours following the initiation of ascorbic acid therapy...
  55. Andress J, Day T, Day D. The effects of consecutive day propofol anesthesia on feline red blood cells. Vet Surg. 1995;24:277-82 pubmed
    ..day of propofol anesthesia, there was a significant increase from baseline in the mean percentage of Heinz bodies. Hemolysis was not detected in any cat...
  56. Norambuena E, Videla L, Lissi E. Interaction of nitrobenzoates with haemoglobin in red blood cells and a haemolysate. Hum Exp Toxicol. 1994;13:345-51 pubmed
  57. Munday R, Fowke E, Smith B, Munday C. Comparative toxicity of alkyl-1,4-naphthoquinones in rats: relationship to free radical production in vitro. Free Radic Biol Med. 1994;16:725-31 pubmed
    ..A close correlation was observed between the in vivo and in vitro parameters, suggesting that the proposed mechanism of toxicity of 2-methyl-1,4-naphthoquinone is correct and is also applicable to other alkylnaphthoquinones...
  58. Yamato O, Sugiyama Y, Matsuura H, Lee K, Goto K, Hossain M, et al. Isolation and identification of sodium 2-propenyl thiosulfate from boiled garlic (Allium sativum) that oxidizes canine erythrocytes. Biosci Biotechnol Biochem. 2003;67:1594-6 pubmed
    ..It seems that this compound is one of the causative agents of garlic-induced hemolysis in dogs...
  59. Han Y, Kwon T, Kim S, Ha H, Lee T, Kim J, et al. Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress. BMB Rep. 2012;45:560-4 pubmed
  60. Bauer M, Weiss D, Perman V. Hematologic alterations in adult cats fed 6 or 12% propylene glycol. Am J Vet Res. 1992;53:69-72 pubmed
    ..Cats fed PG had a dose-related increase in Heinz bodies within 2 weeks, and the increase persisted throughout the study...
  61. Broccio M, Della Rovere F, Granata A, Wanderlingh U, Zirilli A, Tanzariello A, et al. Free radical erythrocyte damage in tumoral disease assessed by He-Ne laser and optical microscope through "Heinz Bodies" method. Anticancer Res. 1998;18:1075-8 pubmed
    ..1 mW), have confirmed the reduction in Heinz Bodies (HB) formation time and the Transmittance Reduction Degree (TRD), in malignancies...
  62. Sen G, Ghosal J, Biswas T. The role of calpain and calpastatin in the catabolism of erythrocyte-membrane proteins during anaemia in hamsters (Mesocricetus auretus) infected with Leishmania donovani. Ann Trop Med Parasitol. 2002;96:787-96 pubmed
    ..91), the percentage of erythrocytes with Heinz bodies (R(2) = 0.98) and thiol depletion (R(2) = 0.96) in the erythrocytes. Calpain (Ca(2+)-activated protease; EC 3.4...
  63. Dewitt S, Bedenice D, Mazan M. Hemolysis and Heinz body formation associated with ingestion of red maple leaves in two alpacas. J Am Vet Med Assoc. 2004;225:578-83, 539 pubmed
    ..This necessitated blood transfusion as a life-saving intervention; however, prior to whole blood being available, transfusion with bovine hemoglobin glutamer was necessary. Both alpacas recovered without complications...
  64. Ronquist G, Theodorsson E. Inherited, non-spherocytic haemolysis due to deficiency of glucose-6-phosphate dehydrogenase. Scand J Clin Lab Invest. 2007;67:105-11 pubmed
    ..parts of the haemoglobin molecule decrease the solubility of haemoglobin, leading to precipitations called Heinz bodies. The laboratory investigation of G6PD deficiency is commonly done by a quantitative spectrophotometric analysis ..
  65. Sugawara Y, Hayashi Y, Shigemasa Y, Abe Y, Ohgushi I, Ueno E, et al. Molecular biosensing mechanisms in the spleen for the removal of aged and damaged red cells from the blood circulation. Sensors (Basel). 2010;10:7099-121 pubmed publisher
    b>Heinz bodies are intraerythrocytic inclusions of hemichrome formed as a result of hemoglobin (Hb) oxidation. They typically develop in aged red cells...
  66. Rumbeiha W, Oehme F. Methylene blue can be used to treat methemoglobinemia in cats without inducing Heinz body hemolytic anemia. Vet Hum Toxicol. 1992;34:120-2 pubmed
    ..Pre-exposure to sodium nitrite potentiated the HB-inducing effect of 2 doses of MB. Hemolytic anemia was not observed or demonstrated in any of the cats groups...
  67. Winterbourn C. Oxidative denaturation in congenital hemolytic anemias: the unstable hemoglobins. Semin Hematol. 1990;27:41-50 pubmed
    ..of methemoglobin to hemichrome and sometimes heme loss, with resultant denaturation and precipitation as Heinz bodies. Methemoglobin formation and recycling are accompanied by release of superoxide...
  68. Winski S, Barber D, Rael L, Carter D. Sequence of toxic events in arsine-induced hemolysis in vitro: implications for the mechanism of toxicity in human erythrocytes. Fundam Appl Toxicol. 1997;38:123-8 pubmed
    ..There was no evidence that further oxidation products (hemin and Heinz bodies) were formed in this system...
  69. Knight A, Lassen D, McBride T, Marsh D, Kimberling C, Delgado M, et al. Adaptation of pregnant ewes to an exclusive onion diet. Vet Hum Toxicol. 2000;42:1-4 pubmed
    ..This adaptation to a pure onion diet is in part likely due to the apparent ability of the sheep's rumen to quickly develop a population of sulfate-reducing bacteria that decrease the toxicity of onion disulfides...
  70. Johnston C, Cox S. Plasma-Saturating intakes of vitamin C confer maximal antioxidant protection to plasma. J Am Coll Nutr. 2001;20:623-7 pubmed
    ..This report examined blood indicators of oxidative stress in subjects consuming graded doses of vitamin C, from 75 to 2,000 mg/day...
  71. Yamoto O, Maede Y. Susceptibility to onion-induced hemolysis in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations. Am J Vet Res. 1992;53:134-7 pubmed
    ..In addition, at 12 hours, the proportion of erythrocytes containing Heinz bodies increased to 24.4% in HK dogs, but increased only to 1.2% in clinically normal dogs...
  72. Yoo D, Lessin L. Drug-associated "bite cell" hemolytic anemia. Am J Med. 1992;92:243-8 pubmed
    ..The morphologic characteristics of bite cells by light microscopy and scanning electron microscopy are detailed in this study, and the pathophysiologic mechanism is discussed...
  73. Ballin A, Brown E, Zipursky A. Idiopathic Heinz body hemolytic anemia in newborn infants. Am J Pediatr Hematol Oncol. 1989;11:3-7 pubmed
    ..It is hypothesized that in these newborn infants, Heinz body hemolytic anemia developed as a result of ingestion of an oxidant contained in feedings. The nature of this agent is as yet unknown...
  74. Vettore L, De Sandre G, Di Iorio E, Winterhalter K, Lang A, Lehmann H. A new abnormal hemoglobin O Padova, alpha 30 (B11) Glu -- Lys, and a dyserythropoietic anemia with erythroblastic multinuclearity coexisting in the same patient. Blood. 1974;44:869-77 pubmed
  75. Bain B. Sudden onset of jaundice in a Sardinian man. Am J Hematol. 2008;83:810 pubmed publisher
  76. Hopmeier P, Binder C, Gadner H, Fischer M. A case of the unstable Hb Genova (beta 28 Leu----Pro) in an Arab child associated with severe haemolytic anaemia and growth retardation. Acta Haematol. 1990;83:39-41 pubmed
    ..It was found in a 13-year-old girl from Libya suffering from chronic Heinz body haemolytic anaemia and growth retardation. The available data strongly suggest that this case represents a new example for a spontaneous mutation...
  77. Weiss D, Perman V, Wustenberg W, Bucci T. Hematologic response of adult brown mink to oxidative stress. Vet Hum Toxicol. 1994;36:109-11 pubmed
    ..However, the high food intake and the mink's position at the top of the food chain may increase its exposure to environmental contaminants...
  78. Liu S, Yi S, Mehta J, Nichols P, Ballas S, Yacono P, et al. Red cell membrane remodeling in sickle cell anemia. Sequestration of membrane lipids and proteins in Heinz bodies. J Clin Invest. 1996;97:29-36 pubmed
    In red cells from patients with sickle cell anemia, hemoglobin S denatures and forms Heinz bodies. Binding of Heinz bodies to the inner surface of the sickle cell membrane promotes clustering and colocalization of the membrane protein ..
  79. Nakanishi A, Kinuta K, Abe T, Araki K, Yoshida Y, Liang S, et al. Formation of meso, N-diphenylprotoporphyrin IX by an aerobic reaction of phenylhydrazine with oxyhemoglobins. Acta Med Okayama. 2003;57:249-56 pubmed
    ..the denaturation of hemoglobins in erythrocytes, causing the formation of intracellular precipitates known as Heinz bodies, severe hemolytic anemia, and reticulocytosis...
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    ..This function is essential for normal erythropoiesis and, to a greater extent, in beta-thalassemia. Our findings raise the possibility that altered AHSP expression levels could modulate the severity of beta-thalassemia in humans...
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    ..The substitution alpha 86 Leu leads to Arg, which is next to the heme binding proximal histidine, is responsible for a marked instability of the molecule. The oxygen affinity of the erythrocytes was found to be slightly decreased...
  82. Uyesaka N, Hasegawa S, Imai H, Nakamura T, Furuhama K. Possible role of red cell deformability and microvasculature in microcirculation. Jpn J Physiol. 1992;42:891-904 pubmed
    ..The present study has considerable implications concerning the link between in vitro experiments and the in vivo situation, including the hemodynamic characteristics of RBC suspensions such as the effective viscosity...
  83. Petty H, Zhou M, Zheng Z. Oxidative damage by phenylhydrazine diminishes erythrocyte anion transport. Biochim Biophys Acta. 1991;1064:308-14 pubmed
    ..shown to trigger the production of toxic oxygen metabolites including O-2 and H2O2 and the formation of Heinz bodies. The concentration-dependent formation of Heinz bodies was confirmed using optical microscopy...
  84. Blair P, Thompson M, Bechtold M, Wilson R, Moorman M, Fowler B. Evidence for oxidative damage to red blood cells in mice induced by arsine gas. Toxicology. 1990;63:25-34 pubmed
    ..Additionally, the presence of Heinz bodies in blood smears stained with brilliant cresyl blue and decreases in reduced glutathione concentrations in red ..
  85. Prache S. Haemolytic anaemia in ruminants fed forage brassicas: a review. Vet Res. 1994;25:497-520 pubmed
    ..The factors responsible for variations in the haemolysis severity are then discussed as well as the measures for preventing pathological risks. Emphasis is placed on the identification of topics which need increased research activity...
  86. Tuohy A, McKie V, Sabio H, Kutlar F, Kutlar A, Wilson J. Hb Hammersmith [beta 42(CD1) Phe-->Ser]: occurrence as a de novo mutation in black monozygotic twins with multiple congenital anomalies. J Pediatr Hematol Oncol. 1998;20:563-6 pubmed
    ..To present the occurrence of Hb Hammersmith as a de novo mutation in African-American twins with multiple congenital anomalies...
  87. Dimisianos G, Traeger Synodinos J, Vrettou C, Papassotiriou I, Kanavakis E. A rare 33 bp in-frame deletion (alpha63-74 or alpha64-74 or alpha65-75) in the alpha1-globin gene causing alpha(+)-thalassemia: a second observation. Hemoglobin. 2004;28:137-43 pubmed
    ..The observation of inclusion and Heinz bodies indicates the synthesis of some abnormal Hb (or globin chains)...
  88. Mehler K, Oberthuer A, Weisshaar G, Valter M, Vierzig A, Eifinger F. Hemolytic anemia and methemoglobinemia in a preterm baby as a complication of antenatal intraamnial injection of toluidine blue. Klin Padiatr. 2013;225:263-5 pubmed publisher
    ..These complications underline that antenatal exposition of toluidine blue may result in considerable postnatal infant morbidity. Therefore intraamniotic application of toluidine blue should be discouraged. ..
  89. Lincoln S, Howell M, Combs J, Hinman D. Hematologic effects and feeding performance in cattle fed cull domestic onions (Allium cepa). J Am Vet Med Assoc. 1992;200:1090-4 pubmed
    ..b>Heinz bodies were detected in erythrocytes of all cattle fed onions, and the percentage was proportional to the amount of ..
  90. Cox Ganser J, Jung G, Pushkin R, Reid R. Evaluation of Brassicas in grazing systems for sheep: II. Blood composition and nutrient status. J Anim Sci. 1994;72:1832-41 pubmed
    ..rapidly in lambs on Brassicas, with small decreases in packed cell volume (PCV); dosing with I+CuO reduced Heinz bodies in lambs on Tyfon and turnip pastures. In Exp...
  91. Pyo H, Kwon Y, Wee K, Kwon S, Lee C, Kim S, et al. An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients. Korean J Intern Med. 1993;8:93-8 pubmed
    ..It is concluded that chloramine is one of the major contaminants causing dialysis-induced hemolytic anemia and regular determinations are necessary, especially during winter and dry seasons...
  92. Houston D, Myers S. A review of Heinz-body anemia in the dog induced by toxins. Vet Hum Toxicol. 1993;35:158-61 pubmed
    ..We review the available literature and discuss onions, methylene blue, acetaminophen, zinc, benzocaine, vitamin K and phenylhydrazine as toxic materials capable of inducing Heinz-body formation in the dog...