b lymphocyte subsets

Summary

Summary: A classification of B-lymphocytes based on structurally or functionally different populations of cells.

Top Publications

  1. Shimomura Y, Mizoguchi E, Sugimoto K, Kibe R, Benno Y, Mizoguchi A, et al. Regulatory role of B-1 B cells in chronic colitis. Int Immunol. 2008;20:729-37 pubmed publisher
    ..We conclude that B-1 cells play a regulatory role in T(h)2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora...
  2. O Neill S, Cao Y, Hamel K, Doodes P, Hutas G, Finnegan A. Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis. J Immunol. 2007;179:5109-16 pubmed
    ..These results demonstrate that a CD80/86:CD28 costimulatory interaction between B cells and T cells is required for autoreactive T cell activation and the induction of arthritis but not for B cell autoantibody production...
  3. Ehrhardt G, Hijikata A, Kitamura H, Ohara O, Wang J, Cooper M. Discriminating gene expression profiles of memory B cell subpopulations. J Exp Med. 2008;205:1807-17 pubmed publisher
  4. Bouaziz J, Yanaba K, Tedder T. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev. 2008;224:201-14 pubmed publisher
    ..This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions...
  5. Torres V, VanCompernolle S, Sundrud M, Unutmaz D, Cover T. Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. J Immunol. 2007;179:5433-40 pubmed
    ..We propose that the immunomodulatory actions of VacA on T and B lymphocytes, the major effectors of the adaptive immune response, may contribute to the ability of H. pylori to establish a persistent infection in the human gastric mucosa...
  6. Lebien T, Tedder T. B lymphocytes: how they develop and function. Blood. 2008;112:1570-80 pubmed publisher
    ..Despite the significant advances that have been made at the cellular and molecular levels, there is much more to learn, and cross-disciplinary studies in hematology and immunology will continue to pave the way for new discoveries...
  7. Jacobi A, Mei H, Hoyer B, Mumtaz I, Thiele K, Radbruch A, et al. HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus. Ann Rheum Dis. 2010;69:305-8 pubmed publisher
    ..A similar subset has also been identified 6-8 days after tetanus/diphtheria vaccination in normal individuals and in patients with infectious disease...
  8. Thurlings R, Vos K, Wijbrandts C, Zwinderman A, Gerlag D, Tak P. Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response. Ann Rheum Dis. 2008;67:917-25 pubmed
    ..To investigate the synovial tissue in patients with rheumatoid arthritis (RA) treated with rituximab and to identify possible predictors of clinical response...
  9. Moir S, Ho J, Malaspina A, Wang W, DiPoto A, O Shea M, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med. 2008;205:1797-805 pubmed publisher
    ..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals...

More Information

Publications86

  1. Xiu Y, Wong C, Bouaziz J, Hamaguchi Y, Wang Y, Pop S, et al. B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol. 2008;180:2863-75 pubmed
    ..Moreover, this study defines a new, clinically relevant approach whereby B cell depletion early in the course of disease development may prevent diabetes or delay progression of disease...
  2. Wardemann H, Nussenzweig M. B-cell self-tolerance in humans. Adv Immunol. 2007;95:83-110 pubmed
    ..Here we summarize recent data on the self-reactive B-cell repertoire in healthy humans and in patients with autoimmunity...
  3. Chang N, McKenzie T, Bonventi G, Landolt Marticorena C, Fortin P, Gladman D, et al. Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus. J Immunol. 2008;180:1276-84 pubmed
    ..Although controls also had IgD+IgMlowCD23+ cells, they were reduced in number and not activated. Thus, there is an altered response to Ig receptor engagement with self-Ags in lupus...
  4. Barr T, Brown S, Ryan G, Zhao J, Gray D. TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells. Eur J Immunol. 2007;37:3040-53 pubmed
    ..QRT-PCR array data indicate that this may be due to differential expression of TLR signalling molecules, effectors and adaptors. Our data highlight the potentially unique nature of immune modulation when B cells act as APC...
  5. Dorner T, Jacobi A, Lipsky P. B cells in autoimmunity. Arthritis Res Ther. 2009;11:247 pubmed publisher
    ..Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential...
  6. Gururajan M, Jacob J, Pulendran B. Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS ONE. 2007;2:e863 pubmed
    ..Furthermore, the expression and functional relevance of TLRs on distinct subsets of B cells, which are known to play differential roles in humoral responses is not known...
  7. Yanaba K, Bouaziz J, Haas K, Poe J, Fujimoto M, Tedder T. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28:639-50 pubmed publisher
    ..Thereby, CD1d(hi)CD5(+) B cells represent a unique subset of potent regulatory B cells...
  8. Correale J, Farez M, Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol. 2008;64:187-99 pubmed publisher
    ..To assess the importance of B-cell control during parasite infections in multiple sclerosis (MS) patients...
  9. Gambichler T, Tigges C, Burkert B, Hoxtermann S, Altmeyer P, Kreuter A. Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis. Eur J Med Res. 2010;15:44-6 pubmed
    ..Previous reports on lymphocyte subpopulations in systemic sclerosis (SSc) are conflicting. Therefore, we aimed to investigate the lymphocyte subsets in SSc patients who were not on immunosuppressive therapy...
  10. Monroe J, Dorshkind K. Fate decisions regulating bone marrow and peripheral B lymphocyte development. Adv Immunol. 2007;95:1-50 pubmed
  11. Avanzini M, Maccario R, Belloni C, Carrera G, Bertaina A, Cagliuso M, et al. B lymphocyte subsets and their functional activity in the early months of life. Int J Immunopathol Pharmacol. 2010;23:247-54 pubmed
    ..Our results underline that the susceptibility and severe course of infection in the neonate can be attributed, at least in part, to the lack of pre-existing immunological memory and competent adaptive immunity...
  12. Marie Cardine A, Divay F, Dutot I, Green A, Perdrix A, Boyer O, et al. Transitional B cells in humans: characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation. Clin Immunol. 2008;127:14-25 pubmed publisher
    ..Our results now formally demonstrate that transitional B cells are necessary developmental intermediates for human mature B cell generation...
  13. Weller S, Mamani Matsuda M, Picard C, Cordier C, Lecoeuche D, Gauthier F, et al. Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants. J Exp Med. 2008;205:1331-42 pubmed publisher
    ..These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses...
  14. Rosado M, Aranburu A, Capolunghi F, Giorda E, Cascioli S, Cenci F, et al. From the fetal liver to spleen and gut: the highway to natural antibody. Mucosal Immunol. 2009;2:351-61 pubmed publisher
    ..The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria...
  15. Roll P, Dorner T, Tony H. Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and B cell subset regeneration after repeated treatment. Arthritis Rheum. 2008;58:1566-75 pubmed publisher
    ..The effects on B cell homeostasis after repeated treatments and the relationship of certain B cell subsets to clinical response or relapse are currently not known...
  16. Crowley J, Scholz J, Quinn W, Stadanlick J, Treml J, Treml L, et al. Homeostatic control of B lymphocyte subsets. Immunol Res. 2008;42:75-83 pubmed publisher
    ..A refined understanding of these relationships should yield insight into the selection and maintenance of B cell subsets, as well as an appreciation of how homeostatic mechanisms may contribute to immunosenescence...
  17. Lee J, Kuchen S, Fischer R, Chang S, Lipsky P. Identification and characterization of a human CD5+ pre-naive B cell population. J Immunol. 2009;182:4116-26 pubmed publisher
    ..These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus...
  18. Sanz I, Wei C, Lee F, Anolik J. Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol. 2008;20:67-82 pubmed publisher
  19. Jacobi A, Reiter K, Mackay M, Aranow C, Hiepe F, Radbruch A, et al. Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum. 2008;58:1762-73 pubmed publisher
    ..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE...
  20. Binard A, Le Pottier L, Devauchelle Pensec V, Saraux A, Youinou P, Pers J. Is the blood B-cell subset profile diagnostic for Sjogren syndrome?. Ann Rheum Dis. 2009;68:1447-52 pubmed publisher
    ..To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome...
  21. Moens L, Wuyts M, Meyts I, De Boeck K, Bossuyt X. Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response. J Immunol. 2008;181:5306-12 pubmed
    ..We transplanted SCID/SCID mice with human B lymphocyte subsets and immunized them with heat-inactivated Streptococcus pneumoniae or with a pneumococcal vaccine...
  22. Capolunghi F, Cascioli S, Giorda E, Rosado M, Plebani A, Auriti C, et al. CpG drives human transitional B cells to terminal differentiation and production of natural antibodies. J Immunol. 2008;180:800-8 pubmed
    ..Therefore, the ability of transitional B cells to sense bacterial DNA through TLR9 represents a tool to rapidly build up the repertoire of natural Abs necessary for our first-line defense at birth...
  23. Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, et al. Novel human transitional B cell populations revealed by B cell depletion therapy. J Immunol. 2009;182:5982-93 pubmed publisher
    ..The characterization of multiple transitional B cell subpopulations provides important insights into human B cell development...
  24. Mauri C, Ehrenstein M. The 'short' history of regulatory B cells. Trends Immunol. 2008;29:34-40 pubmed publisher
    ..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies...
  25. Singh A, Carson W, Secor E, Guernsey L, Flavell R, Clark R, et al. Regulatory role of B cells in a murine model of allergic airway disease. J Immunol. 2008;180:7318-26 pubmed
    ..These findings illustrated a novel regulatory role for regional B cells in AAD and suggested a possible contributory role of B cells, along with other cell types, in the establishment of LIT...
  26. van Zelm M, Szczepanski T, van der Burg M, van Dongen J. Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J Exp Med. 2007;204:645-55 pubmed
    ..We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio between genomic coding joints and signal joints on kappa-deleting recombination ..
  27. Stoermann B, Kretschmer K, Düber S, Weiss S. B-1a cells are imprinted by the microenvironment in spleen and peritoneum. Eur J Immunol. 2007;37:1613-20 pubmed
    ..This suggests that the environment induces the particular genetic program of B-1a cells and argues against an independent ontogeny...
  28. Merrell K, Benschop R, Gauld S, Aviszus K, Decote Ricardo D, Wysocki L, et al. Identification of anergic B cells within a wild-type repertoire. Immunity. 2006;25:953-62 pubmed
    ..In conclusion, our findings indicate that anergy is probably the primary mechanism by which autoreactive B cells are silenced. Thus maintenance of the unresponsiveness of anergic cells is critical for prevention of autoimmunity...
  29. Wei C, Anolik J, Cappione A, Zheng B, Pugh Bernard A, Brooks J, et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol. 2007;178:6624-33 pubmed
    ..These findings enhance our understanding of the B cell diversification pathways and provide mechanistic insight into the immunopathogenesis of SLE...
  30. Evans J, Chavez Rueda K, Eddaoudi A, Meyer Bahlburg A, Rawlings D, Ehrenstein M, et al. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol. 2007;178:7868-78 pubmed
    ..The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential...
  31. Genestier L, Taillardet M, Mondiere P, Gheit H, Bella C, Defrance T. TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J Immunol. 2007;178:7779-86 pubmed
  32. Jacobi A, Goldenberg D, Hiepe F, Radbruch A, Burmester G, Dorner T. Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls. Ann Rheum Dis. 2008;67:450-7 pubmed
    ..Epratuzumab, a humanised anti-CD22 monoclonal antibody, is currently in clinical trials, although its effects on patients' B cells are not completely understood...
  33. Carrasco Y, Batista F. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity. 2007;27:160-71 pubmed
    ..These observations not only provide evidence of a B cell role as antigen transporters into the follicle, but also highlight the boundary between the follicle and the SCS as a site for initiation of B cell responses...
  34. Pers J, Devauchelle V, Daridon C, Bendaoud B, Le Berre R, Bordron A, et al. BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome. Arthritis Rheum. 2007;56:1464-77 pubmed
    ..The purpose of this study was to track the repopulation of B cell subsets in PB as well as their subsequent homing into SGs in patients with primary SS treated with rituximab...
  35. Looney R. Will targeting B cells be the answer for Sjögren's syndrome?. Arthritis Rheum. 2007;56:1371-7 pubmed
  36. Amu S, Tarkowski A, Dorner T, Bokarewa M, Brisslert M. The human immunomodulatory CD25+ B cell population belongs to the memory B cell pool. Scand J Immunol. 2007;66:77-86 pubmed publisher
    ..In conclusion, CD20(+)25(+) B cells constitute a unique subpopulation preferentially occurring among CD20(+)27(+) memory B cells. We suggest that CD25 can be used as a marker for a memory B cell subset...
  37. Pao L, Lam K, Henderson J, Kutok J, Alimzhanov M, Nitschke L, et al. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity. 2007;27:35-48 pubmed
    ..Thus, Shp1 deficiency in B cells alone perturbs B cell development and causes autoimmune disease...
  38. Bourges D, Chevaleyre C, Wang C, Berri M, Zhang X, Nicaise L, et al. Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T- and sIgA+ B-lymphocyte recruitment. Immunology. 2007;122:551-61 pubmed
  39. Hansen A, Lipsky P, Dorner T. B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. Arthritis Res Ther. 2007;9:218 pubmed
    ..These findings add to our understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches...
  40. Donahue A, Fruman D. Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur J Immunol. 2007;37:2923-36 pubmed
    ..These data define both similarities and differences in PI3K/mTOR signaling mechanisms in MZ and FO cells, and suggest that mTOR signaling can occur in the absence of PI3K activation to promote B cell responses to LPS...
  41. Fekete A, Soos L, Szekanecz Z, Szabo Z, Szodoray P, Barath S, et al. Disturbances in B- and T-cell homeostasis in rheumatoid arthritis: suggested relationships with antigen-driven immune responses. J Autoimmun. 2007;29:154-63 pubmed
  42. Schelonka R, Tanner J, Zhuang Y, Gartland G, Zemlin M, Schroeder H. Categorical selection of the antibody repertoire in splenic B cells. Eur J Immunol. 2007;37:1010-21 pubmed
  43. Teague B, Pan Y, Mudd P, Nakken B, Zhang Q, Szodoray P, et al. Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus. J Immunol. 2007;178:7511-5 pubmed
    ..Significantly reduced numbers of T3 B cells in young lupus-prone mice further suggest that the specificity of this subset holds clues to understanding autoimmunity...
  44. Hoffmann A, Kerr S, Jellusova J, Zhang J, Weisel F, Wellmann U, et al. Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol. 2007;8:695-704 pubmed
    ..Siglec-G-deficient B1 cells showed a strongly enhanced calcium signaling. Our results demonstrate that Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells...
  45. Tangye S, Good K. Human IgM+CD27+ B cells: memory B cells or "memory" B cells?. J Immunol. 2007;179:13-9 pubmed
    ..In this review we will provide alternate interpretations of the biology of IgM+CD27+ B cells and propose that they are indeed memory cells...
  46. Wiedermann U, Wiltschke C, Jasinska J, Kundi M, Zurbriggen R, Garner Spitzer E, et al. A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study. Breast Cancer Res Treat. 2010;119:673-83 pubmed
    ..The induction of anti-Her-2-specific antibodies could result in clinical benefit comparable to passive anti-Her-2 antibody therapy. ..
  47. Kuhrt D, Faith S, Leone A, Rohankedkar M, Sodora D, Picker L, et al. Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population. J Virol. 2010;84:2466-76 pubmed publisher
    ..These data indicate that dynamic B-cell population changes in SIV-infected macaques arise very early after infection at the precise time when an effective adaptive immune response is needed. ..
  48. Bingham C, Looney R, Deodhar A, Halsey N, Greenwald M, Codding C, et al. Immunization responses in rheumatoid arthritis patients treated with rituximab: results from a controlled clinical trial. Arthritis Rheum. 2010;62:64-74 pubmed publisher
    ..These data suggest that polysaccharide and primary immunizations should be administered prior to rituximab infusions to maximize responses. ..
  49. Deng C, Xiang Y, Tan T, Ren Z, Cao C, Huang G, et al. Altered Peripheral B-Lymphocyte Subsets in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults. Diabetes Care. 2016;39:434-40 pubmed publisher
    ..These findings suggest that B lymphocytes may be involved in loss of self-tolerance and β-cell destruction and could be used as a biomarker and potential target for immunological intervention. ..
  50. Hanson C, Morice W. The clinical and laboratory approach to the CD5/CD10 negative B-cell chronic lymphoproliferative leukemias. Am J Hematol. 2008;83:347-8 pubmed publisher
  51. Gregson A, Hoji A, Saggar R, Ross D, Kubak B, Jamieson B, et al. Bronchoalveolar immunologic profile of acute human lung transplant allograft rejection. Transplantation. 2008;85:1056-9 pubmed publisher
    ..A unique BALF lymphocyte profile was associated with rejection and may provide insight into the pathogenesis of allograft rejection. ..
  52. Freitas do Rosario A, Muxel S, Rodriguez Málaga S, Sardinha L, Zago C, Castillo Méndez S, et al. Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody. J Immunol. 2008;181:8344-55 pubmed
    ..Furthermore, by analyzing adoptive transfer experiments, we confirmed the major role of CD4(+) T cells for guaranteeing long-term full protection against P. chabaudi malaria. ..
  53. James S, Greenberg P, Jensen M, Lin Y, Wang J, Budde L, et al. Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation. J Immunol. 2010;184:4284-94 pubmed publisher
  54. Gross A, Lyandres J, Panigrahi A, Prak E, DeFranco A. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009;182:5382-92 pubmed publisher
  55. Aust J, Gays F, Mickiewicz K, Buchanan E, Brooks C. The expression and function of the NKRP1 receptor family in C57BL/6 mice. J Immunol. 2009;183:106-16 pubmed publisher
  56. Allman D, Pillai S. Peripheral B cell subsets. Curr Opin Immunol. 2008;20:149-57 pubmed publisher
  57. Tabrizi S, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, et al. T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. J Immunol. 2009;182:1490-9 pubmed
    ..These results suggest that a unique set of molecules, Tcl1 and Gal-1, defines distinct BCR signaling cascades, dictating survival and death of human naive and IgM(+) memory B cells. ..
  58. Haas K, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, et al. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. J Immunol. 2010;184:4789-800 pubmed publisher
    ..Therefore, distinct B cell populations can have opposing protective and pathogenic roles during lupus progression. ..
  59. Kamperschroer C, Roberts D, Zhang Y, Weng N, Swain S. SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol. 2008;181:3994-4003 pubmed
    ..Instead, SAP is necessary for very late stages of differentiation or, most likely, for allowing Th cells to communicate during cognate T:B interactions. ..
  60. Abulayha A, Tabal S, Shawesh E, Elbasir M, Elbanani A, Lamami Y, et al. Depletion of peripheral blood B cells with Rituximab and phenotype characterization of the recovering population in a patient with follicular lymphoma. Leuk Res. 2010;34:307-11 pubmed publisher
    ..These cells had a naive B cell phenotype (IgD+, CD27-) and they expressed high levels of CD38 and CD24, which show that the B cell pool was repopulated mainly with immature, naive B cells. ..
  61. Li X, Xiao B, Xi J, Lu C, Lu J. Decrease of CD4(+)CD25(high)Foxp3(+) regulatory T cells and elevation of CD19(+)BAFF-R(+) B cells and soluble ICAM-1 in myasthenia gravis. Clin Immunol. 2008;126:180-8 pubmed
  62. Benatuil L, Kaye J, Cretin N, Godwin J, Cariappa A, Pillai S, et al. Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies. J Immunol. 2008;180:3839-48 pubmed
    ..We suggest that in these mice, receptor editing functioned to lower the affinity for self-Ag below a threshold that would result in overt pathology, while allowing development of low affinity anti-self Abs. ..
  63. Henderson R, Grys K, Vehlow A, de Bettignies C, Zachacz A, Henley T, et al. A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med. 2010;207:837-53 pubmed publisher
    ..Thus, these studies identify a novel developmental checkpoint that coincides with B cell positive selection. ..
  64. Andréasson U, Edén P, Peterson C, Hogerkorp C, Jerkeman M, Andersen N, et al. Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples. Am J Hematol. 2010;85:418-25 pubmed publisher
    ..The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment...
  65. Moir S, Fauci A. B cells in HIV infection and disease. Nat Rev Immunol. 2009;9:235-45 pubmed publisher
    ..This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction. ..
  66. Schelonka R, Zemlin M, Kobayashi R, Ippolito G, Zhuang Y, Gartland G, et al. Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production. J Immunol. 2008;181:8409-15 pubmed
    ..These findings indicate that B cell development and Ag-specific Ab production can be heavily influenced by the global amino acid content of the CDR-H3 repertoire. ..
  67. Misra R, Shi G, Moreno Garcia M, Thankappan A, Tighe M, Mousseau B, et al. G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med. 2010;207:1775-89 pubmed publisher
    ..Together, these data show for the first time that signaling through trimeric G proteins is critically important for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity. ..
  68. Lin F, Baldessari F, Gyenge C, Sato T, Chambers R, Santiago J, et al. Lymphocyte electrotaxis in vitro and in vivo. J Immunol. 2008;181:2465-71 pubmed
    ..Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well. ..
  69. Rafei M, Hsieh J, Zehntner S, Li M, Forner K, Birman E, et al. A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties. Nat Med. 2009;15:1038-45 pubmed publisher
    ..We propose that autologous GIFT15 B(reg) cells may serve as a new treatment for autoimmune ailments. ..
  70. Lang V, Mielenz D, Neubert K, Böhm C, Schett G, Jack H, et al. The early marginal zone B cell-initiated T-independent type 2 response resists the proteasome inhibitor bortezomib. J Immunol. 2010;185:5637-47 pubmed publisher
    ..In contrast, the early T-independent type 2 response protecting the organism against blood-borne pathogens remains largely intact due to a remarkable resistance of MZ B cells against proteasome inhibition...
  71. Rodríguez Bayona B, Ramos Amaya A, Pérez Venegas J, Rodriguez C, Brieva J. Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients. Arthritis Res Ther. 2010;12:R108 pubmed publisher
    ..The phenotypic analysis of blood B cell subsets can be used to understand these alterations...
  72. Wittenbrink N, Weber T, Klein A, Weiser A, Zuschratter W, Sibila M, et al. Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations. J Immunol. 2010;184:1339-47 pubmed publisher
    ..Possible causes of GC B cell population collapses are discussed in the context of the affinity-maturation process...
  73. Chaganti S, Ma C, Bell A, Croom Carter D, Hislop A, Tangye S, et al. Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients. Blood. 2008;112:672-9 pubmed publisher
    ..These results provide the first definitive evidence that EBV can establish persistence in the B-cell system in the absence of fully functional germinal center activity and of a class-switched memory B-cell compartment...
  74. Popi A, Motta F, Mortara R, Schenkman S, Lopes J, Mariano M. Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro. Immunology. 2009;126:114-22 pubmed publisher
    ..The maintenance of lymphoid characteristics in B-1CDPs characterizes a unique type of phagocyte, not related to monocyte-derived macrophages...
  75. Nakajima P, Kiefer K, Price A, Bosma G, Bosma M. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009;182:3583-96 pubmed publisher
    ..We suggest that the unique CDR3 region of the tg-encoded muH chain is responsible for the lambda5 independence of tg-expressing B cells...
  76. Lund F, Randall T. Effector and regulatory B cells: modulators of CD4+ T cell immunity. Nat Rev Immunol. 2010;10:236-47 pubmed publisher
    ..In this Review, we discuss recent data showing how effector and regulatory B cells modulate CD4(+) T cell responses to pathogens and autoantigens...
  77. Narvaez C, Franco M, Angel J, Morton J, Greenberg H. Rotavirus differentially infects and polyclonally stimulates human B cells depending on their differentiation state and tissue of origin. J Virol. 2010;84:4543-55 pubmed publisher
    ..Thus, RV differentially interacts with primary human B cells depending on their tissue of origin and differentiation stage, and it affects their capacity to modulate the local and systemic immune responses...