antibody producing cells


Summary: Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.

Top Publications

  1. Manz R, Hauser A, Hiepe F, Radbruch A. Maintenance of serum antibody levels. Annu Rev Immunol. 2005;23:367-86 pubmed
  2. Walter J, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, et al. Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. J Exp Med. 2010;207:1541-54 pubmed publisher
  3. Corcoran L, Karvelas M. Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity. 1994;1:635-45 pubmed
    ..Responses to signals from activated T cells are unaffected. The requirement for Oct-2 maps to an early activation step in G1, during which B cells make the commitment to progress through the cell cycle and to divide...
  4. Smith K, Nossal G, Tarlinton D. FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen. Proc Natl Acad Sci U S A. 1995;92:11628-32 pubmed
    ..The results suggest that the size and composition of B-cell compartments in the humoral immune response are regulated by mechanisms that do not require FAS...
  5. Cox R, Mykkeltvedt E, Robertson J, Haaheim L. Non-lethal viral challenge of influenza haemagglutinin and nucleoprotein DNA vaccinated mice results in reduced viral replication. Scand J Immunol. 2002;55:14-23 pubmed
    ..In conclusion, intramuscular DNA vaccination resulted in immunological memory in the systemic compartment, which was rapidly reactivated upon viral challenge...
  6. Lee C, Suh C, Lee J, Kim Y, Lee S. The effects of anti-idiotypic antibody on antibody production and apoptosis of anti-dsDNA antibody producing cells. Clin Exp Rheumatol. 2003;21:291-300 pubmed
    ..The purpose of the present study was to assess the effect of anti-Id on anti-dsDNA antibody production and apoptosis and to study the mechanism of anti-Id induced apoptosis...
  7. Shaffer A, Shapiro Shelef M, Iwakoshi N, Lee A, Qian S, Zhao H, et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity. 2004;21:81-93 pubmed
    ..Thus, XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells...
  8. Kallies A, Hasbold J, Tarlinton D, Dietrich W, Corcoran L, Hodgkin P, et al. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med. 2004;200:967-77 pubmed
    ..Thus, maturation from transient plasmablast to long-lived ASCs in bone marrow is predicated on quantitative increases in Blimp-1 expression...
  9. Corcoran L, Hasbold J, Dietrich W, Hawkins E, Kallies A, Nutt S, et al. Differential requirement for OBF-1 during antibody-secreting cell differentiation. J Exp Med. 2005;201:1385-96 pubmed
    ..These studies define a new regulatory role for OBF-1 in determining the cell-autonomous capacity of B cells to undergo terminal differentiation in response to different immunological signals...

More Information

Publications170 found, 100 shown here

  1. Szyszko E, Brokstad K, Cox R, Hovden A, Madhun A, Haaheim L. Impact of influenza vaccine formulation with a detailed analysis of the cytokine response. Scand J Immunol. 2006;64:467-75 pubmed
  2. Cassani B, Poliani P, Marrella V, Schena F, Sauer A, Ravanini M, et al. Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome. J Exp Med. 2010;207:1525-40 pubmed publisher
    ..BAFF-R blockade reduced serum levels of nucleic acid-specific autoantibodies and significantly ameliorated inflammatory tissue damage. These findings highlight a role for B cells in OS pathogenesis...
  3. Hovden A, Cox R, Haaheim L. Whole influenza virus vaccine is more immunogenic than split influenza virus vaccine and induces primarily an IgG2a response in BALB/c mice. Scand J Immunol. 2005;62:36-44 pubmed
    ..The increased immunogenicity of whole virus vaccine in a naïve population could reduce the vaccine concentration needed to provide protective immunity...
  4. Riggs J, Feeney A, Kirven M, Mosier D. VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer. Mol Immunol. 1994;31:783-91 pubmed
    ..These results suggest that successful V-D-J recombination is occurring with low frequency in all SCID mice, and that neonatal T cell transfer plus autoantigen stimulation allows the long term survival of these B cells. ..
  5. Einav S, Pozdnyakova O, Ma M, Carroll M. Complement C4 is protective for lupus disease independent of C3. J Immunol. 2002;168:1036-41 pubmed
    ..Thus, complement C4 provides an important protective role against the development of SLE. ..
  6. Ozaki K, Spolski R, Feng C, Qi C, Cheng J, Sher A, et al. A critical role for IL-21 in regulating immunoglobulin production. Science. 2002;298:1630-4 pubmed
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID. ..
  7. Ramezani Rad P, Rickert R. Murine models of germinal center derived-lymphomas. Curr Opin Immunol. 2017;45:31-36 pubmed publisher
    ..Herein we discuss advances in murine models of lymphoma and how they inform on key characteristics of human lymphomas. ..
  8. Foss D, Murtaugh M. Mucosal immunogenicity and adjuvanticity of cholera toxin in swine. Vaccine. 1999;17:788-801 pubmed
    ..These results suggest that CT is immunogenic and is a potent adjuvant for CT-B in swine and that the induction of mucosal immunity to heterologous antigens may require specific targeting to the gut-associated lymphoid tissues. ..
  9. Wenneras C, Qadri F, Bardhan P, Sack R, Svennerholm A. Intestinal immune responses in patients infected with enterotoxigenic Escherichia coli and in vaccinees. Infect Immun. 1999;67:6234-41 pubmed
    ..Still, a correlation between numbers of CF-specific B cells in blood sampled from patients early during infection and numbers of duodenal B cells collected 1 week later was apparent (r = 0.70; n = 10; P = 0.03). ..
  10. White K, Germolec D, Booker C, Hernendez D, McCay J, Delclos K, et al. Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats. Toxicology. 2005;207:271-81 pubmed
    ..Increases in antibody-forming cell response and NK cell activity, and altered spleen cell subpopulation numbers were observed in the F1 generation male rats, without similar changes to the F1 generation females. ..
  11. Shen X, Klarić L, Sharapov S, Mangino M, Ning Z, Wu D, et al. Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation. Nat Commun. 2017;8:447 pubmed publisher
    ..Here the authors conduct a multivariate GWAS on IgG N-glycosylation phenotypes and identify 5 novel loci enriched in immune system genes. ..
  12. Ohdan H, Swenson K, Kruger Gray H, Yang Y, Xu Y, Thall A, et al. Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice. J Immunol. 2000;165:5518-29 pubmed
    ..They are consistent with a model whereby B-1b cells lose Mac-1 expression upon Ag exposure and that these, rather than plasma cells, become the major IgM Ab-producing cell population. ..
  13. Lu F, Ma Z, Moser S, Evans T, Miller C. Effects of ovarian steroids on immunoglobulin-secreting cell function in healthy women. Clin Diagn Lab Immunol. 2003;10:944-9 pubmed
    ..Thus, endogenous ovarian steroids regulate the ISC frequency and this may explain why women are more resistant to viral infections and tend to have more immune-mediated diseases than men do. ..
  14. Jellison E, Guay H, Szomolanyi Tsuda E, Welsh R. Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen. Eur J Immunol. 2007;37:119-28 pubmed
    ..This approach, therefore, formally demonstrates and quantifies a virus-induced polyclonal proliferation and differentiation of B cells, which, due to their high proportion, would mostly have BCR not specific for the virus. ..
  15. Brown A, Claassen E. In situ analysis of antibody-forming cells from the BALB/c CRIc idiotype family: idiotopic heterogeneity among clustered cells. Cell Immunol. 1989;119:1-13 pubmed
    ..The approach also allowed in situ idiotypic analysis of polyclonally activated B AFC...
  16. Freier D, Wright K, Klein K, Voll D, Dabiri K, Cosulich K, et al. Enhancement of the humoral immune response by Echinacea purpurea in female Swiss mice. Immunopharmacol Immunotoxicol. 2003;25:551-60 pubmed
    ..This supports the acute use of E. purpurea as suggested by anecdotal reports, and demonstrates the potential for enhancement of humoral immune responses as well as innate immune responses. ..
  17. Lu Y, Singh M, Cerny J. Canonical germinal center B cells may not dominate the memory response to antigenic challenge. Int Immunol. 2001;13:643-55 pubmed
    ..2(+) cells. These data suggest that the late primary and secondary responses to a hapten may be born by different B cell lineages, and that some clonotypes may reach the memory pool without an extensive mutation and expansion. ..
  18. Xu Y, Yang Y, Ohdan H, Ryan D, Harper D, Wu C, et al. Characterization of anti-Gal antibody-producing cells of baboons and humans. Transplantation. 2006;81:940-8 pubmed
    ..After antigen exposure, anti-Gal IgM and IgG were secreted by both B and plasma cells. These results suggest strategies to remove xenoreactive antibody-secreting cells prior to transplantation. ..
  19. Chang S, Cha H, Uematsu S, Akira S, Igarashi O, Kiyono H, et al. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008;180:1609-18 pubmed
    ..Taken together, our results suggest the possibility that cross-talk could occur between the large intestine and the systemic immune compartments via the colonic patches without the assistance of innate immunity...
  20. Achatz Straussberger G, Zaborsky N, Königsberger S, Luger E, Lamers M, Crameri R, et al. Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR. Eur J Immunol. 2008;38:3167-77 pubmed publisher
    ..We conclude that IgE plasmablasts have an intrinsic, lower chance to contribute to the long-lived plasma cell pool than IgG1 plasmablasts. ..
  21. Gevorgyan M, Idova G, Al perina E, Tikhonova M, Kulikov A. Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State. Bull Exp Biol Med. 2016;161:266-9 pubmed publisher
    ..The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state. ..
  22. Jiao X, Hirano T, Gu X. [Detection of LOS-specific antibody-secreting cells by ELISPOT assay]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004;20:366-9 pubmed
    ..ELISPOT assay is quick, sensitive, specific, and would be a very useful tool to analyze dynamically the mechanism of single antibody-secreting cell response. ..
  23. Siwicki A, Morand M, Fuller J, Nissen S, Kazun K, Glombski E. Influence of HMB (beta-hydroxy-beta-methylbutyrate) on antibody secreting cells (ASC) after in vitro and in vivo immunization with the anti-Yersinia ruckeri vaccine of rainbow trout (Oncorhynchus mykiss). Vet Res. 2001;32:491-8 pubmed
    ..In conclusion, the results of the present study showed that HMB increases the levels of specific ASC after both in vitro and in vivo immunization of rainbow trout with the anti-Yersinia ruckeri vaccine. ..
  24. Raphael T, Kuttan G. Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid. Immunopharmacol Immunotoxicol. 2003;25:285-94 pubmed
    ..Administration of terpenoids increased the total antibody production, antibody producing cells in spleen, bone marrow cellularity and alpha-esterase positive cells significantly compared to the normal ..
  25. Dandekar A, Jacobsen G, Waldschmidt T, Perlman S. Antibody-mediated protection against cytotoxic T-cell escape in coronavirus-induced demyelination. J Virol. 2003;77:11867-74 pubmed
    ..These findings indicate a key role for the anti-MHV antibody response in suppressing virus replication, thereby minimizing the emergence and competitive advantage of CTL escape mutants...
  26. Mao X, Zhang J, Han Y, Luan C, Hu Y, Hao Z, et al. Deficient for endoplasmic reticulum calcium sensors Stim1 and Stim2 affects aberrant antibody affinity maturation in B cells. Oncotarget. 2016;7:60885-60895 pubmed publisher
    ..In conclusion, calcium influx plays an important role in antibody affinity maturation in humoral immune responses. The knowledge can be used in manipulate humoral immune response for the design of effective vaccines. ..
  27. Davydova S, Idova G. [Presynaptic 5-HT1A receptors in immunomodulation]. Ross Fiziol Zh Im I M Sechenova. 2007;93:1156-62 pubmed
    ..The data obtained indicate that the somatodendric 5-HT1A autoreceptors are involved in immunomodulation. ..
  28. Han X, Lin X, Seliger A, Eastcott J, Kawai T, Taubman M. Expression of receptor activator of nuclear factor-kappaB ligand by B cells in response to oral bacteria. Oral Microbiol Immunol. 2009;24:190-6 pubmed publisher
    ..This study suggests that B-lymphocyte involvement in the immune response to A. actinomycetemcomitans through upregulation of RANKL expression potentially contribute to bone resorption in periodontal disease. ..
  29. Halliley J, Kyu S, Kobie J, Walsh E, Falsey A, Randall T, et al. Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization. Vaccine. 2010;28:3582-7 pubmed publisher
    ..After immunization with inactivated influenza vaccine the peak in influenza-specific ASC frequencies is variable but correlates well with the magnitude of protective HAI responses. ..
  30. Han S, Yang K, Ozen Z, Peng W, Marinova E, Kelsoe G, et al. Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. J Immunol. 2003;170:1267-73 pubmed
  31. Tacket C, Pasetti M, Edelman R, Howard J, Streatfield S. Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn. Vaccine. 2004;22:4385-9 pubmed
    ..Four (44%) of nine volunteers also developed stool IgA. Transgenic plants represent a new vector for oral vaccine antigens. ..
  32. Tribble D, Kaminski R, Cantrell J, Nelson M, Porter C, Baqar S, et al. Safety and immunogenicity of a Shigella flexneri 2a Invaplex 50 intranasal vaccine in adult volunteers. Vaccine. 2010;28:6076-85 pubmed publisher
    ..The Invaplex 50 nasal vaccine was safe with encouraging mucosal immune responses. Follow-on studies will optimize dose, delivery mechanism and assess efficacy in a S. flexneri 2a challenge study. ..
  33. Owen F, Riblet R, Taylor B. The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor. J Exp Med. 1981;153:801-10 pubmed
    ..The map position suggest that the Tsu(d) antigen is a constant region allotypic determinant on the as yet uncharacterized T cell receptor. ..
  34. Thoree V, Golby S, Boursier L, Hackett M, Dunn Walters D, Sanderson J, et al. Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis. Gut. 2002;51:44-50 pubmed
    ..Overall, these data are consistent with a model of UC in which a peripheral response is expressed and expanded in the colonic mucosa. ..
  35. Min K, Kim P. Macrophage-derived TGF-beta1 induces IgA isotype expression. Mol Cells. 2003;16:245-50 pubmed
    ..The supernatant from such an activated P388D1 culture, in combination of IL-2, stimulated IgA secretion and this effect was abolished by anti-TGFbeta1 antibody. ..
  36. Misefari A, Valenti A, Cavallaro A, Sofo V, Santarpia G, Salmeri F, et al. Prostaglandin E2-induced inhibition of the in vitro immune response by SRBC-stimulated human lymphocytes. Immunopharmacol Immunotoxicol. 1991;13:169-81 pubmed
    ..The effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge. ..
  37. van Driel I, Wilks A, Pietersz G, Goding J. Murine plasma cell membrane antigen PC-1: molecular cloning of cDNA and analysis of expression. Proc Natl Acad Sci U S A. 1985;82:8619-23 pubmed
    ..Restriction fragment length polymorphisms were detected in genomic DNA from mice bearing different PC-1 alleles. A related gene is present in rat genomic DNA...
  38. Diaz Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol. 1997;158:2406-13 pubmed
    ..This synergy between DEP and natural allergen exposure is suggested as a key feature in increasing allergen-induced respiratory allergic disease. ..
  39. Tryphonas H, Bondy G, Hodgen M, Coady L, Parenteau M, Armstrong C, et al. Effects of cis-nonachlor, trans-nonachlor and chlordane on the immune system of Sprague-Dawley rats following a 28-day oral (gavage) treatment. Food Chem Toxicol. 2003;41:107-18 pubmed
    ..Therefore, an evaluation of the risk these chlorinated compounds may pose to human health should consider the potential effects different chlordane compounds may have on the immune system. ..
  40. Salomonsson S, Wahren Herlenius M. Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjögren's syndrome. Scand J Rheumatol. 2003;32:79-82 pubmed
    ..The chronic inflammation of the salivary glands in Sjögren's syndrome may be a self-sustaining process promoting autoantibody production in the target organ, possibly contributing to increased serum levels of autoantibodies. ..
  41. Trollmo C, Gudmundsson S, Feltelius N, Rogberg S, Smedegård G, Klareskog L. Sulphasalazine inhibits human antigen-specific immune responses in vivo. Ann Rheum Dis. 2007;66:481-5 pubmed
    ..These data show firstly that SASP exerts an immunosuppressive effect on defined immune responses to immunisation in vivo, and secondly that both mucosa-associated and systemic immunity are affected by SASP treatment. ..
  42. Ali M, Dasari H, Van Keulen V, Cornec D, Vasmatzis G, Peikert T, et al. Microbial Antigens Stimulate Metalloprotease-7 Secretion in Human B-Lymphocytes Using mTOR-Dependent and Independent Pathways. Sci Rep. 2017;7:3869 pubmed publisher
    ..B-lymphocytes, in addition to their well-known function as antibody producing cells, participate in the innate immune response by secreting inflammatory cytokines and chemokines...
  43. Saha N, Usami T, Suzuki Y. In vitro effects of steroid hormones on IgM-secreting cells and IgM secretion in common carp (Cyprinus carpio). Fish Shellfish Immunol. 2004;17:149-58 pubmed
    ..However, no effects of sex steroids were observed in this study. The results show that sex-specific steroid hormones may have no immunosuppressive effects in common carp. ..
  44. Kotloff K, Pasetti M, Barry E, Nataro J, Wasserman S, Sztein M, et al. Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208. J Infect Dis. 2004;190:1745-54 pubmed
    ..We conclude that 1 or both ShETs are virulence determinants in humans; their inactivation, in combination with Delta guaBA, leads to a well-tolerated and immunogenic Shigella vaccine candidate. ..
  45. Drolet J, Frangie H, Guay J, Hajoui O, Hamid Q, Mazer B. B lymphocytes in inflammatory airway diseases. Clin Exp Allergy. 2010;40:841-9 pubmed publisher
    ..B lymphocytes appear to contribute to multiple facets of immune homeostasis in inflammatory diseases of the upper and lower airways...
  46. VanCott J, Brim T, Simkins R, Saif L. Isotype-specific antibody-secreting cells to transmissible gastroenteritis virus and porcine respiratory coronavirus in gut- and bronchus-associated lymphoid tissues of suckling pigs. J Immunol. 1993;150:3990-4000 pubmed
    ..This unique model of mucosal immunity using antigenically related viruses with distinct tissue tropisms may help to clarify interactions of the various components of the common mucosal immune system. ..
  47. Taylor K, Lutje V, Kennedy D, Authie E, Boulange A, Logan Henfrey L, et al. Trypanosoma congolense: B-lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle. Exp Parasitol. 1996;83:106-16 pubmed
    ..congolense. ..
  48. Fries L, Montemarano A, Mallett C, Taylor D, Hale T, Lowell G. Safety and immunogenicity of a proteosome-Shigella flexneri 2a lipopolysaccharide vaccine administered intranasally to healthy adults. Infect Immun. 2001;69:4545-53 pubmed
    ..flexneri 2a LPS vaccine is similar to those reported for live vaccine candidates associated with protective efficacy in human challenge models, and further evaluation of this product is warranted. ..
  49. Liang B, Eaton Bassiri A, Bugelski P. B cells and beyond: therapeutic opportunities targeting inflammation. Inflamm Allergy Drug Targets. 2007;6:142-9 pubmed
    ..These discussions are intended to provide the reader with the basis for viewing B cells as players of a broader role in inflammatory disease and thus suggest avenues for exploiting B cell directed therapy in novel ways. ..
  50. Schiller J, Lowy D. Explanations for the high potency of HPV prophylactic vaccines. Vaccine. 2018;36:4768-4773 pubmed publisher
  51. Hagiwara Y, McGhee J, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, et al. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol. 2003;170:1754-62 pubmed
  52. Hulikova K, Benson V, Svoboda J, Sima P, Fiserova A. N-Acetyl-D-glucosamine-coated polyamidoamine dendrimer modulates antibody formation via natural killer cell activation. Int Immunopharmacol. 2009;9:792-9 pubmed publisher
    ..These results indicate that GlcNAc8-induced upregulation of antibody formation is triggered by NK cell stimulation and depends on expressed NKR-P1 isoforms, particularly NKR-P1C. ..
  53. Daev E, Surinov B, Dukel skaia A, Karpova N, Kulish I, Isaeva V. [Immunological, cytogenetic and behavior changes in male mice CBA and C57BL/6 exposed to pheromone]. Zh Evol Biokhim Fiziol. 2005;41:319-24 pubmed
  54. Stoel M, Evenhuis W, Kroese F, Bos N. Rat salivary gland reveals a more restricted IgA repertoire than ileum. Mol Immunol. 2008;45:719-27 pubmed
    ..The function of the IgA secreted by salivary gland is very likely a first line of defense with (near) germline encoded IgA, whereas in the intestine the majority of utilized IgA VH genes show evidence of somatic hypermutation. ..
  55. El Madhun A, Cox R, Søreide A, Olofsson J, Haaheim L. Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination. J Infect Dis. 1998;178:933-9 pubmed
  56. Bermudez R, Vigliano F, Marcaccini A, Sitja Bobadilla A, Quiroga M, Nieto J. Response of Ig-positive cells to Enteromyxum scophthalmi (Myxozoa) experimental infection in turbot, Scophthalmus maximus (L.): A histopathological and immunohistochemical study. Fish Shellfish Immunol. 2006;21:501-12 pubmed
    ..The results obtained in this study indicate that the infection by E. scophthalmi in turbot induced an immune response that involved changes in the number and distribution of Ig+ cells...
  57. Wu H, Reding M, Qian J, Okita D, Parker E, Lollar P, et al. Mechanism of the immune response to human factor VIII in murine hemophilia A. Thromb Haemost. 2001;85:125-33 pubmed
  58. Aviszus K, Zhang X, Wysocki L. Silent development of memory progenitor B cells. J Immunol. 2007;179:5181-90 pubmed
  59. Zhao X, Findly R, Dickerson H. Cutaneous antibody-secreting cells and B cells in a teleost fish. Dev Comp Immunol. 2008;32:500-8 pubmed
    ..Our demonstration that skin contains B cells and plasma cells suggests that it is an integral component of the teleost immune system. ..
  60. Moreno R, Sampson J, Romero Steiner S, Wong B, Johnson S, Ades E, et al. A murine model for the study of immune memory in response to pneumococcal conjugate vaccination. Vaccine. 2004;22:3069-79 pubmed
    ..This model allows for the screening and determination of potential alternative vaccination regimens and the study of immunological markers of memory following Pnc vaccination. ..
  61. Sabirov A, Kodama S, Sabirova N, Mogi G, Suzuki M. Intranasal immunization with outer membrane protein P6 and cholera toxin induces specific sinus mucosal immunity and enhances sinus clearance of nontypeable Haemophilus influenzae. Vaccine. 2004;22:3112-21 pubmed
    ..Systemic administration of the vaccine did not affect sinus clearance of NTHi. These findings suggest that a nasal vaccine might be useful for preventing sinusitis. ..
  62. Das S, Paul B, Saxena A, Ray P. Effect of in utero exposure to hexachlorocyclohexane on the developing immune system of mice. Immunopharmacol Immunotoxicol. 1990;12:293-310 pubmed
    ..The results, therefore, suggest that lower dose of HCH is capable of modulating the development and function of developing immune system possibly by modulating the functional organization of the T-cell populations. ..
  63. Sprent J, Bruce J. Physiology of B cells in mice with X-linked immunodeficiency (xid). III. Disappearance of xid B cells in double bone marrow chimeras. J Exp Med. 1984;160:711-23 pubmed
    ..The finding that xid B cells eventually disappear in the presence of normal B cells strengthens the view that xid B cells are an abnormal population not represented in normal mice. ..
  64. Zwollo P, Cole S, Bromage E, Kaattari S. B cell heterogeneity in the teleost kidney: evidence for a maturation gradient from anterior to posterior kidney. J Immunol. 2005;174:6608-16 pubmed
    ..Lastly, our data support the notion that the trout kidney is a complex, multifunctional immune organ with the potential to support both hemopoiesis as well as humoral immune activation. ..
  65. Cox R, Hovden A, Brokstad K, Szyszko E, Madhun A, Haaheim L. The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice. Vaccine. 2006;24:6585-7 pubmed
    ..The two vaccine formulations induced different T helper profiles particularly after one dose of vaccine; split virus vaccine induced a type 2 bias response, whereas whole virus vaccine elicited a dominant type 1 response. ..
  66. Herremans T, Reimerink J, Buisman A, Kimman T, Koopmans M. Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus. J Immunol. 1999;162:5011-8 pubmed
    ..It is concluded that IPV vaccination alone is insufficient to induce a mucosal IgA response against poliovirus. In mucosally (OPV-) primed individuals, however, booster vaccination with IPV leads to a strong mucosal IgA response. ..
  67. Sidorova E, Li Sheng L, Devlin B, Chernishova I, Gavrilova M. Role of different B-cell subsets in the specific and polyclonal immune response to T-independent antigens type 2. Immunol Lett. 2003;88:37-42 pubmed
    ..A close parallelism between AFC and nIFC formation was observed. It is concluded that specific and polyclonal immune response to non-self TI-2-PVP-depends mainly on CD5+ B-1 subset. ..
  68. Cuburu N, Kweon M, Hervouet C, Cha H, Pang Y, Holmgren J, et al. Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus infection. J Immunol. 2009;183:7851-9 pubmed publisher
    ..l. immunization as an efficient vaccination strategy for inducing genital immune responses and should impact on the development of vaccines against sexually transmitted diseases. ..
  69. Sirova M, Hovorka O, Riha I, Rihova B, Baudys M, Kim S, et al. The in vivo antibody response against exogenous antigens is not influenced by the mouse Bcg (Nramp1) gene. Immunology. 1997;90:626-31 pubmed
    ..Since the macrophages are the only cells in which the Nramp1 gene is expressed, we suggest that the activity of other types of antigen-presenting cells masks the effect of the Bcgr allele on antigen-presentation in vivo. ..
  70. Asanuma H, Hirokawa K, Uchiyama M, Suzuki Y, Aizawa C, Kurata T, et al. Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine. Vaccine. 2001;19:3981-9 pubmed
    ..These results suggest that local Ab responses, as well as systemic Ab responses, are downregulated in aged mice, although the degree of the downregulation of immune responses differs from strain to strain. ..
  71. Devoino L, Al perina E, Gevorgian M, Cheido M. [Contribution of D2 dopamine receptors of the rat dorsolateral caudate nucleus to immunomodulation]. Ross Fiziol Zh Im I M Sechenova. 2004;90:420-7 pubmed
  72. Liu X, Manser T. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol. 2005;174:4505-15 pubmed
    ..Together, these data reveal a lack of intrinsic anergy involving any known mechanism, supporting the idea that this type of antinuclear Ag B cell becomes indifferent to cognate autoantigen by down-regulating sBCR. ..
  73. Walter B, Valera V, Takahashi S, Matsuno K, Ushiki T. Evidence of antibody production in the rat cervical lymph nodes after antigen administration into the cerebrospinal fluid. Arch Histol Cytol. 2006;69:37-47 pubmed
    ..Thus, the cervical lymph nodes probably act as a monitoring site for cerebrospinal fluid and play a major role in the central nervous system immune response. ..
  74. Larsen D, Karasin A, Olsen C. Immunization of pigs against influenza virus infection by DNA vaccine priming followed by killed-virus vaccine boosting. Vaccine. 2001;19:2842-53 pubmed
  75. Yuan L, Geyer A, Saif L. Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus. Immunology. 2001;103:188-98 pubmed
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    ..By contrast, a subset that gives rise to HA-specific, IgM-secreting ASC persists in the primary repertoire of HA104 mice and can be activated by virus immunization. ..
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    ..The head kidney appears to produce the highest number of specific ASC of the organs tested. It appears that sea bass show a relatively fast but short duration antibody response. ..