acinar cells


Summary: Cells lining the saclike dilatations known as acini of various glands or the lungs.

Top Publications

  1. Chang J, Nicolau M, Cox T, Wetterskog D, Martens J, Barker H, et al. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling. Breast Cancer Res. 2013;15:R67 pubmed
    ..LOXL2 may also be a beneficial marker for breast cancer patients that could benefit most from anti-ErbB2 therapy. ..
  2. Farmer D, Nathan S, Finley J, Shengyang Yu K, Emmerson E, Byrnes L, et al. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017;144:2517-2528 pubmed publisher
    ..Together, our data reveal crucial features of lacrimal gland development that have broad implications for understanding epithelial organogenesis. ..
  3. Kim J, Choi S, Park K. TRPM7 Is Involved in Volume Regulation in Salivary Glands. J Dent Res. 2017;96:1044-1050 pubmed publisher
    ..A typical RVD was observed in submandibular gland acinar cells after swelling in a hypotonic solution, whereas intracellular Ca2+ chelation completely inhibited ..
  4. Gukovsky I, Gukovskaya A. Nuclear factor-?B in pancreatitis: Jack-of-all-trades, but which one is more important?. Gastroenterology. 2013;144:26-9 pubmed publisher
  5. Wollbold J, Jaster R, Müller S, Rateitschak K, Wolkenhauer O. Anti-inflammatory effects of reactive oxygen species - a multi-valued logical model validated by formal concept analysis. BMC Syst Biol. 2014;8:101 pubmed publisher
    Recent findings suggest that in pancreatic acinar cells stimulated with bile acid, a pro-apoptotic effect of reactive oxygen species (ROS) dominates their effect on necrosis and spreading of inflammation...
  6. Ferdek P, Jakubowska M, Nicolaou P, Gerasimenko J, Gerasimenko O, Petersen O. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis. 2017;8:e2640 pubmed publisher
  7. Da Y, Niu K, Liu S, Wang K, Wang W, Jia J, et al. Does Cimicifuga racemosa have the effects like estrogen on the sublingual gland in ovariectomized rats?. Biol Res. 2017;50:11 pubmed publisher
    ..staining showed that the ratio of caspase-3 positive cells was significantly increased in the acinar cells of the OVX group compared with the SHAM group (p < 0...
  8. Watanabe T, Yamashita K, Arai Y, Minaga K, Kamata K, Nagai T, et al. Chronic Fibro-Inflammatory Responses in Autoimmune Pancreatitis Depend on IFN-? and IL-33 Produced by Plasmacytoid Dendritic Cells. J Immunol. 2017;198:3886-3896 pubmed publisher
    ..whereas patients with both conventional pancreatitis and IgG4-related AIP exhibited increased numbers of acinar cells expressing IL-33, only the latter also exhibited pDCs producing this cytokine...
  9. Charrier A, Chen R, Kemper S, Brigstock D. Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2). Immunology. 2014;141:564-76 pubmed publisher
    Pancreatitis is caused by long-term heavy alcohol consumption, which results in injury and death of pancreatic acinar cells (PAC)...

More Information


  1. Milberg O, Shitara A, Ebrahim S, Masedunskas A, Tora M, Tran D, et al. Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals. J Cell Biol. 2017;216:1925-1936 pubmed publisher
    ..Our data support a dual role for the actomyosin cytoskeleton in providing the mechanical forces required to remodel the lipid bilayer and serving as a scaffold to recruit key regulatory molecules. ..
  2. Chean J, Chen C, Shively J. ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348. Exp Cell Res. 2017;359:62-75 pubmed publisher
  3. Storz P. Acinar cell plasticity and development of pancreatic ductal adenocarcinoma. Nat Rev Gastroenterol Hepatol. 2017;14:296-304 pubmed publisher
    b>Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation to a progenitor-like cell type with ductal characteristics...
  4. Emmerson E, May A, Nathan S, Cruz Pacheco N, Lizama C, Maliskova L, et al. SOX2 regulates acinar cell development in the salivary gland. elife. 2017;6: pubmed publisher
    b>Acinar cells play an essential role in the secretory function of exocrine organs. Despite this requirement, how acinar cells are generated during organogenesis is unclear...
  5. Zeng M, Szymczak M, Ahuja M, Zheng C, Yin H, Swaim W, et al. Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017;153:1148-1159 pubmed publisher
    ..Glandular, ductal, and acinar cells damage, infiltration, immune cells and function were measured in vivo and in isolated duct/acini...
  6. Ding L, Liou G, Schmitt D, Storz P, Zhang J, Billadeau D. Glycogen synthase kinase-3? ablation limits pancreatitis-induced acinar-to-ductal metaplasia. J Pathol. 2017;243:65-77 pubmed publisher
    ..We show that GSK-3? promotes TGF-?-induced ADM in 3D cultured primary acinar cells, whereas deletion of GSK-3? attenuates caerulein-induced ADM formation and PanIN progression in KrasG12D
  7. Veite Schmahl M, Joesten W, Kennedy M. HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer. Br J Cancer. 2017;117:639-647 pubmed publisher
  8. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle N, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017;32:824-839.e8 pubmed publisher
    ..We show that accumulation of the autophagy substrate p62/SQSTM1 in stressed KrasG12D acinar cells is associated with PDAC development and maintenance of malignancy in human cells and mice...