cells

Summary

Summary: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary.

Top Publications

  1. Chaouiya C, Bérenguier D, Keating S, Naldi A, van Iersel M, Rodriguez N, et al. SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools. BMC Syst Biol. 2013;7:135 pubmed publisher
    ..While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing...
  2. Xiao F, Gao W, Wang X, Chen T. Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells. Apoptosis. 2012;17:600-11 pubmed publisher
    ..to explore the roles of caspase-8, -9 and -3 during ARTE-induced apoptosis in human lung adenocarcinoma (ASTC-a-1) cells. ARTE treatment induces a rapid generation of reactive oxygen species (ROS), and ROS-dependent apoptosis as well ..
  3. Lee S, Kim J, Jung H, Chi S, Chung S, Lee C, et al. Glyceraldehyde-3-phosphate, a glycolytic intermediate, prevents cells from apoptosis by lowering S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase. J Microbiol Biotechnol. 2012;22:571-3 pubmed
    ..Based on these results, we suggest that G-3-P functions as a molecule switch between cell survival and apoptosis by regulating S-nitrosylation of GAPDH...
  4. Gao Y, Shi J, Yuan D, Xu B. Imaging enzyme-triggered self-assembly of small molecules inside live cells. Nat Commun. 2012;3:1033 pubmed publisher
    ..in water to form nanofibres, besides generating sophisticated biomaterials, promises a simple system inside cells for regulating cellular processes...
  5. Mideo N, Reece S, Smith A, Metcalf C. The Cinderella syndrome: why do malaria-infected cells burst at midnight?. Trends Parasitol. 2013;29:10-6 pubmed publisher
  6. Yan X, Yang L, Wang Q. Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges. Anal Bioanal Chem. 2013;405:5663-70 pubmed publisher
    ..of ICPMS-based protein quantification for universal, selective, or targeted quantification of proteins and cells in a biological sample are also discussed critically...
  7. McVicker G, van de Geijn B, Degner J, Cain C, Banovich N, Raj A, et al. Identification of genetic variants that affect histone modifications in human cells. Science. 2013;342:747-9 pubmed publisher
    ..Furthermore, variants that affect chromatin at distal regulatory sites frequently also direct changes in chromatin and gene expression at associated promoters. ..
  8. Wang X, Fang H, Huang Z, Shang W, Hou T, Cheng A, et al. Imaging ROS signaling in cells and animals. J Mol Med (Berl). 2013;91:917-27 pubmed publisher
    ..The past decade has witnessed significant progress in ROS imaging at levels of intact cells, whole organs or tissues, and even live organisms...
  9. Zhang P. Correlative cryo-electron tomography and optical microscopy of cells. Curr Opin Struct Biol. 2013;23:763-70 pubmed publisher
    ..While cryo-electron tomography (cryoET) provides three-dimensional (3D) still pictures of near-native state cells and organelles at molecular resolution, fluorescence light microscopy (fLM) offers movies of dynamic cellular ..

More Information

Publications92

  1. Darzynkiewicz Z, Zhao H, Halicka H, Rybak P, Dobrucki J, Wlodkowic D. DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis. Crit Rev Clin Lab Sci. 2012;49:199-217 pubmed publisher
    ..Critically assessed is interpretation of the data as to whether the observed DDS events report induction of a particular type of DNA lesion...
  2. O Sullivan A, O Callaghan Y, O Grady M, Quéguineur B, Hanniffy D, Troy D, et al. Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells. Food Chem. 2012;134:1137-40 pubmed publisher
    ..vesiculosus and Fucus serratus to protect against tert-butyl hydroperoxide (tert-BOOH) induced stress in Caco-2 cells was investigated...
  3. Lee J, Lee G. Effect of sodium butyrate on autophagy and apoptosis in Chinese hamster ovary cells. Biotechnol Prog. 2012;28:349-57 pubmed publisher
    ..To determine the effect of NaBu on autophagy as well as apoptosis of rCHO cells, rCHO cells producing erythropoietin were subjected to NaBu treatment...
  4. Kamiya Y, Satoh T, Kato K. Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells. Biochim Biophys Acta. 2012;1820:1327-37 pubmed publisher
    ..e. folding in the endoplasmic reticulum (ER), vesicular transport between the ER and the Golgi complex, and ER-associated degradation of glycoproteins, by interacting with a panel of intracellular lectins in the early secretory pathway...
  5. Timm A, Yin J. Kinetics of virus production from single cells. Virology. 2012;424:11-7 pubmed publisher
    The production of virus by infected cells is an essential process for the spread and persistence of viral diseases, the effectiveness of live-viral vaccines, and the manufacture of viruses for diverse applications...
  6. Seltmann S, Stachelscheid H, Damaschun A, Jansen L, Lekschas F, Fontaine J, et al. CELDA -- an ontology for the comprehensive representation of cells in complex systems. BMC Bioinformatics. 2013;14:228 pubmed publisher
    The need for detailed description and modeling of cells drives the continuous generation of large and diverse datasets. Unfortunately, there exists no systematic and comprehensive way to organize these datasets and their information...
  7. Horobin R, Rashid Doubell F, Pediani J, Milligan G. Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells. Biotech Histochem. 2013;88:440-60 pubmed publisher
    ..used to investigate the structure, composition, physicochemical properties and biological functions of living cells, tissues and organisms...
  8. Ferris C, Gilmore K, Wallace G, in het Panhuis M. Biofabrication: an overview of the approaches used for printing of living cells. Appl Microbiol Biotechnol. 2013;97:4243-58 pubmed publisher
    ..bio-inks which must not only be easily printable, but also allow controllable and reproducible printing of cells. This review outlines the general principles and current progress and compares the advantages and challenges for ..
  9. Okie J. General models for the spectra of surface area scaling strategies of cells and organisms: fractality, geometric dissimilitude, and internalization. Am Nat. 2013;181:421-39 pubmed publisher
    Surface areas and volumes of biological systems-from molecules to organelles, cells, and organisms-affect their biological rates and kinetics...
  10. Malatesta M, Zancanaro C, Costanzo M, Cisterna B, Pellicciari C. Simultaneous ultrastructural analysis of fluorochrome-photoconverted diaminobenzidine and gold immunolabelling in cultured cells. Eur J Histochem. 2013;57:e26 pubmed publisher
    ..This simple and reliable procedure exploits a single sample to simultaneously localise the photoconversion product and a variety of antigens allowing a specific identification of subcellular organelles at the ultrastructural level. ..
  11. Cummings K, Levy D, Wodarz D. Increased burst size in multiply infected cells can alter basic virus dynamics. Biol Direct. 2012;7:16 pubmed publisher
    ..It is, however, clear that especially in the context of high viral load, cells can become infected with multiple copies of a virus, a process called coinfection...
  12. Sale J. Competition, collaboration and coordination--determining how cells bypass DNA damage. J Cell Sci. 2012;125:1633-43 pubmed publisher
    b>Cells must overcome replication blocks that might otherwise lead to genomic instability or cell death...
  13. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y, et al. High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells. Nature. 2014;509:487-91 pubmed publisher
    ..clustered regularly interspaced short palindromic repeats/CRISPR-associated) lentiviral library in human cells and a method of gene identification based on functional screening and high-throughput sequencing analysis...
  14. Lu N, Zhou Z. Membrane trafficking and phagosome maturation during the clearance of apoptotic cells. Int Rev Cell Mol Biol. 2012;293:269-309 pubmed publisher
    Apoptosis is a cellular suicide process that quietly and efficiently eliminates unwanted or damaged cells. In metazoans, cells that undergo apoptosis are swiftly internalized by phagocytes and subsequently degraded inside phagosomes ..
  15. Hörner M, Weber W. Molecular switches in animal cells. FEBS Lett. 2012;586:2084-96 pubmed publisher
  16. Höfling F, Franosch T. Anomalous transport in the crowded world of biological cells. Rep Prog Phys. 2013;76:046602 pubmed publisher
    ..This is commonly attributed to macromolecular crowding in the interior of cells and in cellular membranes, summarizing their densely packed and heterogeneous structures...
  17. Jumpertz T, Rennhack A, Ness J, Baches S, Pietrzik C, Bulic B, et al. Presenilin is the molecular target of acidic ?-secretase modulators in living cells. PLoS ONE. 2012;7:e30484 pubmed publisher
    ..binds the N-terminal fragment of presenilin (PSEN), the catalytic subunit of the ?-secretase complex, in living cells. Labeling was not observed for APP or any of the other ?-secretase subunits...
  18. Kuffer C, Kuznetsova A, Storchova Z. Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells. Chromosoma. 2013;122:305-18 pubmed publisher
    Erroneously arising tetraploid mammalian cells are chromosomally instable and may facilitate cell transformation...
  19. Helikar T, Kowal B, Rogers J. A cell simulator platform: the cell collective. Clin Pharmacol Ther. 2013;93:393-5 pubmed publisher
    ..e., higher-level (mal)functions that are more than the sum of their parts. Systems biology provides a new approach to understanding biological systems and diseases from a holistic perspective...
  20. Parkinson D, Epperly L, McDermott G, Le Gros M, Boudreau R, Larabell C. Nanoimaging cells using soft X-ray tomography. Methods Mol Biol. 2013;950:457-81 pubmed publisher
    Soft X-ray microscopy is ideally suited to visualizing and quantifying biological cells. Specimens, including eukaryotic cells, are imaged intact, unstained and fully hydrated, and therefore visualized in a near-native state...
  21. Bassan P, Sachdeva A, Kohler A, Hughes C, Henderson A, Boyle J, et al. FTIR microscopy of biological cells and tissue: data analysis using resonant Mie scattering (RMieS) EMSC algorithm. Analyst. 2012;137:1370-7 pubmed publisher
    Transmission and transflection infrared microscopy of biological cells and tissue suffer from significant baseline distortions due to scattering effects, predominantly resonant Mie scattering (RMieS)...
  22. Mulkidjanian A, Bychkov A, Dibrova D, Galperin M, Koonin E. Origin of first cells at terrestrial, anoxic geothermal fields. Proc Natl Acad Sci U S A. 2012;109:E821-30 pubmed publisher
    All cells contain much more potassium, phosphate, and transition metals than modern (or reconstructed primeval) oceans, lakes, or rivers...
  23. Wehbe K, Filik J, Frogley M, Cinque G. The effect of optical substrates on micro-FTIR analysis of single mammalian cells. Anal Bioanal Chem. 2013;405:1311-24 pubmed publisher
    The study of individual cells with infrared (IR) microspectroscopy often requires living cells to be cultured directly onto a suitable substrate...
  24. Fridman K, Mader A, Zwerger M, Elia N, Medalia O. Advances in tomography: probing the molecular architecture of cells. Nat Rev Mol Cell Biol. 2012;13:736-42 pubmed publisher
    Visualizing the dynamic molecular architecture of cells is instrumental for answering fundamental questions in cellular and structural biology...
  25. Fendt S, Bell E, Keibler M, Olenchock B, Mayers J, Wasylenko T, et al. Reductive glutamine metabolism is a function of the ?-ketoglutarate to citrate ratio in cells. Nat Commun. 2013;4:2236 pubmed publisher
    ..Thus, targeting reductive glutamine conversion for a therapeutic benefit might require distinct modulations of metabolite concentrations rather than targeting the upstream signalling, which only indirectly affects the process. ..
  26. Wang B, Buck M. Customizing cell signaling using engineered genetic logic circuits. Trends Microbiol. 2012;20:376-84 pubmed publisher
    b>Cells live in an ever-changing environment and continuously sense, process and react to environmental signals using their inherent signaling and gene regulatory networks...
  27. Botchway S, Reynolds P, Parker A, O Neill P. Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells. Methods Enzymol. 2012;504:3-28 pubmed publisher
    ..the propagation and processing of deoxyribonucleic acid (DNA) damage (and repair) in both targeted and nontargeted cells, the latter being able to study cell-cell (bystander) effects...
  28. Wang G, Fang N. Detecting and tracking nonfluorescent nanoparticle probes in live cells. Methods Enzymol. 2012;504:83-108 pubmed publisher
    Precisely imaging and tracking dynamic biological processes in live cells are crucial for both fundamental research in life sciences and biomedical applications...
  29. Takahashi T, Suzuki T. Role of sulfatide in normal and pathological cells and tissues. J Lipid Res. 2012;53:1437-50 pubmed publisher
  30. Lam C, Suárez Diez M, Godinho M, Martins Dos Santos V. Programmable bacterial catalysis - designing cells for biosynthesis of value-added compounds. FEBS Lett. 2012;586:2184-90 pubmed publisher
    ..Continuous improvements are necessary to keep up with increasing demands in terms of complexity, scale, and predictability of biosynthesis products...
  31. Djebali S, Lagarde J, Kapranov P, Lacroix V, Borel C, Mudge J, et al. Evidence for transcript networks composed of chimeric RNAs in human cells. PLoS ONE. 2012;7:e28213 pubmed publisher
    ..The non-random nature of the connection of the genes involved suggest that chimeric transcripts should not be studied in isolation, but together, as an RNA network. ..
  32. Helikar T, Kowal B, McClenathan S, Bruckner M, Rowley T, Madrahimov A, et al. The Cell Collective: toward an open and collaborative approach to systems biology. BMC Syst Biol. 2012;6:96 pubmed publisher
    Despite decades of new discoveries in biomedical research, the overwhelming complexity of cells has been a significant barrier to a fundamental understanding of how cells work as a whole...
  33. Astudillo A, Balgoma D, Balboa M, Balsinde J. Dynamics of arachidonic acid mobilization by inflammatory cells. Biochim Biophys Acta. 2012;1821:249-56 pubmed publisher
    ..This review summarizes recent results applying mass spectrometry-based lipidomic approaches to the identification of AA-containing glycerophospholipids, phospholipid AA remodeling and synthesis of oxygenated metabolites...
  34. Tang W, Fei Y, Page M. Biological significance of RNA editing in cells. Mol Biotechnol. 2012;52:91-100 pubmed publisher
  35. Fan J, Chen J, April C, Fisher J, Klotzle B, Bibikova M, et al. Highly parallel genome-wide expression analysis of single mammalian cells. PLoS ONE. 2012;7:e30794 pubmed publisher
    ..We have developed a high-throughput amplification method for generating robust gene expression profiles using single cell or low RNA inputs...
  36. Erol A. Death-associated proliferation kinetic in normal and transformed cells. Cell Cycle. 2012;11:1512-6 pubmed publisher
    ..DAPK), interacts with PKM2 protein and stabilizes PKM2 in its active tetrameric form in normal proliferating cells. However, DAPK is widely inactivated in cancer cells, leading to the loss of the active conformation of PKM2...
  37. Morkvėnaitė Vilkončienė I, Ramanaviciene A, Ramanavicius A. Atomic force microscopy as a tool for the investigation of living cells. Medicina (Kaunas). 2013;49:155-64 pubmed
    Atomic force microscopy is a valuable and useful tool for the imaging and investigation of living cells in their natural environment at high resolution...
  38. Gaudin R, de Alencar B, Arhel N, Benaroch P. HIV trafficking in host cells: motors wanted!. Trends Cell Biol. 2013;23:652-62 pubmed publisher
    Throughout the viral replication cycle, viral proteins, complexes, and particles need to be transported within host cells. These transport events are dependent on the host cell cytoskeleton and molecular motors...
  39. Slattery S, Newberg J, Szafran A, Hall R, Brinkley B, Mancini M. A framework for image-based classification of mitotic cells in asynchronous populations. Assay Drug Dev Technol. 2012;10:161-78 pubmed publisher
    ..HCS is essential to identify clinically suitable anticancer drugs that disrupt the aberrant mitotic activity of cells. One challenge for integration of cell cycle analysis into HCS is that cells must be chemically synchronized to ..
  40. Weidele K, Kunzmann A, Schmitz M, Beneke S, Burkle A. Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells. Biochem Pharmacol. 2010;80:1103-12 pubmed publisher
    ..Here we chose supplementation of cells with the NAD(+) precursor nicotinic acid (NA) as a strategy...
  41. Pan Y, Berg M, Zhang S, Noh H, Cao H, Chang R, et al. Measurement and autocorrelation analysis of two-dimensional light-scattering patterns from living cells for label-free classification. Cytometry A. 2011;79:284-92 pubmed publisher
    ..an ICCD to record the two-dimensional angular optical scattering (TAOS) patterns retrieved from single aerosolized cells. We analyze these patterns by performing autocorrelations and demonstrate that we are able to retrieve cell size ..
  42. Dima A, Elliott J, Filliben J, Halter M, Peskin A, Bernal J, et al. Comparison of segmentation algorithms for fluorescence microscopy images of cells. Cytometry A. 2011;79:545-59 pubmed publisher
    The analysis of fluorescence microscopy of cells often requires the determination of cell edges. This is typically done using segmentation techniques that separate the cell objects in an image from the surrounding background...
  43. Cierniewski C, Papiewska Pajak I, Malinowski M, Sacewicz Hofman I, Wiktorska M, Kryczka J, et al. Thymosin beta4 regulates migration of colon cancer cells by a pathway involving interaction with Ku80. Ann N Y Acad Sci. 2010;1194:60-71 pubmed publisher
    ..with colorectal carcinoma (CRC) progression evidently due to an increase of the motility and invasion of tumor cells and the induction of a proangiogenic phenotype of endothelial cells...
  44. Michowski W, Ferretti R, Wisniewska M, Ambrozkiewicz M, Beresewicz M, Fusella F, et al. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta. 2010;1803:1043-9 pubmed publisher
    ..The expression time profile of morgana/Chp-1 in NIH3T3 cells in response to heat stress is similar to that of Hsp70, a classical effector of Heat Shock Factor-1 mediated ..
  45. Li Y, Thompson H, Hemphill C, Hong F, Forrester J, Johnson R, et al. An improved one-tube RT-PCR protocol for analyzing single-cell gene expression in individual mammalian cells. Anal Bioanal Chem. 2010;397:1853-9 pubmed publisher
    It is well known that gene expression is regulated at the level of individual cells, and more evidence is now emerging that heterogeneity of cell regulation is orders of magnitude greater than previously thought...
  46. Wang X, Chang W, Wong C, Colcher D, Sherman M, Ostberg J, et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood. 2011;118:1255-63 pubmed publisher
    ..After lentiviral transduction of human T cells with vectors that coordinately express tumor-specific chimeric antigen receptors and huEGFRt, we show that huEGFRt ..
  47. Hervas Stubbs S, Perez Gracia J, Rouzaut A, Sanmamed M, Le Bon A, Melero I. Direct effects of type I interferons on cells of the immune system. Clin Cancer Res. 2011;17:2619-27 pubmed publisher
    ..induces the Janus activated kinase-signal transducer and activation of transcription (JAK-STAT) pathway in most cells, along with other biochemical pathways that may differentially operate, depending on the responding cell subset, ..
  48. Webb H, Truong V, Hasan J, Crawford R, Ivanova E. Physico-mechanical characterisation of cells using atomic force microscopy - Current research and methodologies. J Microbiol Methods. 2011;86:131-9 pubmed publisher
    ..information on prokaryotic and eukaryotic cell surfaces, and the extracellular material produced by the cells. It helps to generate important data on the mechanical properties of cells, such as hardness and elasticity...
  49. Gremse M, Chang A, Schomburg I, Grote A, Scheer M, Ebeling C, et al. The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources. Nucleic Acids Res. 2011;39:D507-13 pubmed publisher
    ..It is widely used by lab scientists, curators of genomic and biochemical databases and bioinformaticians. The BTO is freely available at http://www.obofoundry.org. ..
  50. Margittai E, Sitia R. Oxidative protein folding in the secretory pathway and redox signaling across compartments and cells. Traffic. 2011;12:1-8 pubmed publisher
  51. Dill K, Ghosh K, Schmit J. Physical limits of cells and proteomes. Proc Natl Acad Sci U S A. 2011;108:17876-82 pubmed publisher
    ..Why do mesophilic cells die around 50?°C? How can the maximal growth-rate temperature (around 37?°C) occur so close to the cell-death ..
  52. Lanková M, Smith R, Pesek B, Kubes M, Zazimalova E, Petrasek J, et al. Auxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells. J Exp Bot. 2010;61:3589-98 pubmed publisher
    ..The results suggest that these, previously unknown, activities of putative auxin influx inhibitors regulate overall auxin transport across the plasma membrane depending on the dynamics of particular membrane vesicles. ..
  53. Cabaniols J, Ouvry C, Lamamy V, Fery I, Craplet M, Moulharat N, et al. Meganuclease-driven targeted integration in CHO-K1 cells for the fast generation of HTS-compatible cell-based assays. J Biomol Screen. 2010;15:956-67 pubmed publisher
    ..The authors developed a targeted integration system in Chinese hamster ovary (CHO) cells, called the cellular genome positioning system (cGPS), based on the stimulation of homologous gene targeting by ..
  54. He L, Ingram A, Rybak A, Tang D. Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest. 2010;120:2094-108 pubmed publisher
    ..shank-interacting protein-like 1 (SIPL1) as a PTEN-NR in human tumor cell lines and human primary cervical cancer cells. Ectopic SIPL1 expression protected human U87 glioma cells from PTEN-mediated growth inhibition and promoted the ..
  55. Taniguchi A. Live cell-based sensor cells. Biomaterials. 2010;31:5911-5 pubmed publisher
    Biosensors utilizing live cells have attracted a great deal of attention because of their high specificity and sensitivity to their targets...
  56. Yamaguchi S, Kazuki Y, Nakayama Y, Nanba E, Oshimura M, Ohbayashi T. A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector. PLoS ONE. 2011;6:e17267 pubmed publisher
    The production of cells capable of expressing gene(s) of interest is important for a variety of applications in biomedicine and biotechnology, including gene therapy and animal transgenesis...
  57. Lorentzen A, Bamber J, Sadok A, Elson Schwab I, Marshall C. An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells. J Cell Sci. 2011;124:1256-67 pubmed publisher
    Melanoma cells can switch between an elongated mesenchymal-type and a rounded amoeboid-type migration mode. The rounded 'amoeboid' form of cell movement is driven by actomyosin contractility resulting in membrane blebbing...
  58. Xu G, Fewell C, Taylor C, Deng N, Hedges D, Wang X, et al. Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA. 2010;16:1610-22 pubmed publisher
  59. Krogh A. The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generally. Proc R Soc Med. 1946;133:140-200 pubmed
  60. Mimeault M, Batra S. New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence. Histol Histopathol. 2010;25:1057-73 pubmed publisher
    ..evidence have revealed that the malignant transformation of multipotent tissue-resident adult stem/progenitor cells into cancer stem/progenitor cells endowed with a high self-renewal capacity and aberrant multilineage ..
  61. Hatano A, Chiba H, Moesa H, Taniguchi T, Nagaie S, Yamanegi K, et al. CELLPEDIA: a repository for human cell information for cell studies and differentiation analyses. Database (Oxford). 2011;2011:bar046 pubmed publisher
    CELLPEDIA is a repository database for current knowledge about human cells. It contains various types of information, such as cell morphologies, gene expression and literature references...
  62. Michelini E, Cevenini L, Mezzanotte L, Coppa A, Roda A. Cell-based assays: fuelling drug discovery. Anal Bioanal Chem. 2010;398:227-38 pubmed publisher
    ..This review focuses on main advantages and limitations of different cell-based approaches, and future directions and trends in this fascinating field. ..
  63. Li G, Xie X. Central dogma at the single-molecule level in living cells. Nature. 2011;475:308-15 pubmed publisher
    Gene expression originates from individual DNA molecules within living cells. Like many single-molecule processes, gene expression and regulation are stochastic, that is, sporadic in time...
  64. Eltzov E, Marks R. Whole-cell aquatic biosensors. Anal Bioanal Chem. 2011;400:895-913 pubmed publisher
    ..Examples of the use of a broad spectrum of whole-cell bioreporters in assessing a variety of environmental problems are summarized. ..
  65. Walsh K, Choi M, Oberg K, Kulke M, Yao J, Wu C, et al. A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum. Endocr Relat Cancer. 2011;18:171-80 pubmed publisher
    Genetic studies of midgut carcinoid cancer have exclusively focused on genomic changes of the tumor cells. We investigated the role of constitutional genetic polymorphisms in predisposing individuals to ileal carcinoids...
  66. Gennet N, Gale E, Nan X, Farley E, Takacs K, Oberwallner B, et al. Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate. Proc Natl Acad Sci U S A. 2011;108:9131-6 pubmed publisher
    ..Together, these data identify Dmrt5 as an important player in ventral mesencephalic neural fate specification. ..
  67. Barcelo Coblijn G, Martin M, de Almeida R, Noguera Salva M, Marcilla Etxenike A, Guardiola Serrano F, et al. Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc Natl Acad Sci U S A. 2011;108:19569-74 pubmed publisher
    ..Here, we show that human cancer cells have markedly lower levels of sphingomyelin (SM) than nontumor (MRC-5) cells...
  68. Yu L, Tang H, Jiang X, Tsang L, Chung Y, Chan H. Involvement of calpain-I and microRNA34 in kanamycin-induced apoptosis of inner ear cells. Cell Biol Int. 2010;34:1219-25 pubmed publisher
    Inner ear cells, including hair cells, spiral ganglion cells, stria vascularis cells and supporting cells on the basilar membrane, play a major role in transducing hearing signals and regulating inner ear homoeostasis...
  69. Murphy G, Narayan K, Lowekamp B, Hartnell L, Heymann J, Fu J, et al. Correlative 3D imaging of whole mammalian cells with light and electron microscopy. J Struct Biol. 2011;176:268-78 pubmed publisher
    ..We establish protocols that enable the routine generation of 3D image stacks of entire plastic-embedded mammalian cells by IA-SEM at resolutions of ?10-20nm at high contrast and with minimal artifacts from the focused ion beam...
  70. Palmer E, Freeman T. Large-scale cell-based microarrays and their use with HEK293T cells and downstream apoptotic assays. Methods Mol Biol. 2011;706:27-40 pubmed publisher
    ..These vectors are then packaged in lipid-based transfection reagent, cells grown over the top of the array are transfected and the arrays can then be examined for alterations in cellular ..
  71. Mazumder A, Roopa T, Kumar A, Iyer K, Ramdas N, Shivashankar G. Prestressed nuclear organization in living cells. Methods Cell Biol. 2010;98:221-39 pubmed publisher
    The nucleus is maintained in a prestressed state within eukaryotic cells, stabilized mechanically by chromatin structure and other nuclear components on its inside, and cytoskeletal components on its outside...
  72. Briddon S, Kellam B, Hill S. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods Mol Biol. 2011;746:211-36 pubmed publisher
    ..organised membrane environment has led to an interest in investigating receptor-ligand interactions in single cells. In addition, substantial improvements in imaging technology and an increase in the expense of radioactive waste ..
  73. Li J, Xia W, Huang B, Chen L, Su X, Li S, et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 2010;584:3198-202 pubmed publisher
    ..Our method will make a significant contribution to the study of the biological functions of miRNAs...
  74. Campa V, Kypta R. Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells. Biol Direct. 2011;6:4 pubmed publisher
    ..However, the specificity of these antibodies in immunocytochemistry has not been addressed in any detail...
  75. Spiluttini B, Gu B, Belagal P, Smirnova A, Nguyen V, HEBERT C, et al. Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells. J Cell Sci. 2010;123:2085-93 pubmed publisher
    ..The constitutive association of U1 small nuclear ribonucleoprotein (snRNP) with the transcription machinery might play a role in coupling transcription with pre-mRNA maturation...
  76. Thery M. Micropatterning as a tool to decipher cell morphogenesis and functions. J Cell Sci. 2010;123:4201-13 pubmed publisher
    In situ, cells are highly sensitive to geometrical and mechanical constraints from their microenvironment. These parameters are, however, uncontrolled under classic culture conditions, which are thus highly artefactual...
  77. Kovarik M, Allbritton N. Measuring enzyme activity in single cells. Trends Biotechnol. 2011;29:222-30 pubmed publisher
    Seemingly identical cells can differ in their biochemical state, function and fate, and this variability plays an increasingly recognized role in organism-level outcomes...
  78. Boije H, Ring H, López Gallardo M, Prada C, Hallböök F. Pax2 is expressed in a subpopulation of Müller cells in the central chick retina. Dev Dyn. 2010;239:1858-66 pubmed publisher
    Müller cells in the chick retina are generally thought to be a homogeneous population...
  79. Lagarde F, Jaffrezic Renault N. Cell-based electrochemical biosensors for water quality assessment. Anal Bioanal Chem. 2011;400:947-64 pubmed publisher
    ..b>Cells are easy to cultivate and manipulate, host many enzymes able to catalyse a wide range of biological reactions and ..
  80. Teissier S, Pang C, Thierry F. The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells. Oncogene. 2010;29:5061-70 pubmed publisher
    ..identified E2F5 as a direct activator of HPV18 E6/E7 transcription by sequential silencing of E2F members in HeLa cells. In addition, we could show that E2F5 positively regulates S-phase entry in HeLa cells and that this activation of ..
  81. Daly M. Death by protein damage in irradiated cells. DNA Repair (Amst). 2012;11:12-21 pubmed publisher
    ..Mounting experimental evidence does not fit into this theoretical framework. Whereas DNA lesion-yields in cells exposed to a given dose and type of radiation appear to be fixed, protein lesion-yields are highly variable...
  82. Chen L, Carmichael G. Long noncoding RNAs in mammalian cells: what, where, and why?. Wiley Interdiscip Rev RNA. 2010;1:2-21 pubmed publisher
    ..Here, we discuss some recent progress in our understanding of the functions of a number of important lncRNAs in mammalian cells.
  83. Jung I, Kim T, Kim Ha J. Identification of Drosophila SOD3 and its protective role against phototoxic damage to cells. FEBS Lett. 2011;585:1973-8 pubmed publisher
    ..In addition, the dSod3 protein alleviates ultraviolet-induced cellular damage. These results suggest that dSod3 functions as an extracellular SOD3...