receptor cross talk


Summary: The simultaneous or sequential binding of multiple cell surface receptors to different ligands resulting in coordinated stimulation or suppression of signal transduction.

Top Publications

  1. Saidi H, Melki M, Gougeon M. HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk. PLoS ONE. 2008;3:e3601 pubmed publisher
  2. Wagner E, Nebreda A. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 2009;9:537-49 pubmed publisher
    ..In this Review we highlight the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers. ..
  3. Dong M, Gao F, Pinon D, Miller L. Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors. Mol Endocrinol. 2008;22:1489-99 pubmed publisher
    ..This directly supports the relevance of the endogenous agonist concept to the GLP1 receptor and provides new insights into the rational development and refinement of new types of drugs activating this important receptor. ..
  4. Ricono J, Huang M, Barnes L, Lau S, Weis S, Schlaepfer D, et al. Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res. 2009;69:1383-91 pubmed publisher
    ..These findings show cross-talk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR affect malignant disease. ..
  5. Sieber C, Kopf J, Hiepen C, Knaus P. Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev. 2009;20:343-55 pubmed publisher
    ..Examples of BMP action during development, but also physiological and pathophysiological conditions in the adult organism are presented. ..
  6. Jin Z, Huang C, Dong L, Goda S, Kawanami T, Sawaki T, et al. Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells. Int Immunol. 2008;20:1427-37 pubmed publisher
    ..These findings indicate that membrane SM is crucial for TCR signal transduction, leading to full T cell activation through lipid raft function. ..
  7. Sarid D, Ron I, Shoshan L, Barnea I, Shina S, Baratz M, et al. Invasive breast cancer treated with taxol and epirubicin neo-adjuvant chemotherapy: the role in the outcome of the "crosstalk" between Erb receptors and p53. Anticancer Res. 2008;28:3147-52 pubmed
    ..This observation may help in the development of new strategies required for blocking these molecular pathways and improving the outcome of patients with locally advanced breast cancer. ..
  8. Meyer Wentrup F, Cambi A, Joosten B, Looman M, de Vries I, Figdor C, et al. DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. J Leukoc Biol. 2009;85:518-25 pubmed publisher
    ..These data provide further support to the concept of CLR/TLR cross-talk in modulating immune responses. ..
  9. Salmon A, Neal C, Harper S. New aspects of glomerular filtration barrier structure and function: five layers (at least) not three. Curr Opin Nephrol Hypertens. 2009;18:197-205 pubmed publisher
    ..The structure and function of the glomerular filtration barrier remains an area of significant new discovery, and recent work continues to highlight the complexity of this dynamic multilayered watershed. ..

More Information


  1. Schlondorff D, Banas B. The mesangial cell revisited: no cell is an island. J Am Soc Nephrol. 2009;20:1179-87 pubmed publisher
    ..Another potentially fruitful area of future research is the role of mesangial cells as local modulators of innate and adaptive immune responses. Thus, mesangial cell research still holds much promise. ..
  2. Rahman T, Taylor C. Dynamic regulation of IP3 receptor clustering and activity by IP3. Channels (Austin). 2009;3:226-32 pubmed
    ..These observations reinforce our conclusion that IP(3) dynamically regulates assembly of IP(3)Rs into clusters that underlie the hierarchical recruitment of elementary Ca(2+) release events. ..
  3. Smith T, Sim Selley L, Selley D. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?. Br J Pharmacol. 2010;160:454-66 pubmed publisher
  4. Liu Z, Wang Y, Zhang X, Chen L. Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains. BMC Syst Biol. 2010;4 Suppl 2:S11 pubmed publisher
    ..The global pathway crosstalk network and the clusters of relevant pathways of AD provide evidence of cooperativity among pathways for potential pathogenesis of the neuron complex disease. ..
  5. Li Y, Xu Y, Ling M, Yang Y, Wang S, Li Z, et al. mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells. Environ Health Perspect. 2010;118:936-42 pubmed publisher
    ..mot-2-mediated cross talk between NF-B and p53 appears to be involved in arsenite-induced tumorigenesis of HELF cells. ..
  6. Duthey B, Hübner A, Diehl S, Boehncke S, Pfeffer J, Boehncke W. Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010;19:661-6 pubmed publisher
    ..This study demonstrates a new role for the GABA(B) receptor in inflammation, making it a potential new therapeutic target to treat inflammatory skin diseases...
  7. Ahamed J, Madhivadhani P. Costimulatory role of CXCR4 with pre-TCR and its crosstalk with PI3K in beta-selection of thymocytes. Sci Signal. 2010;3:jc4 pubmed publisher
    ..Thus, a critical role of chemokines and its downstream signaling in the beta-selection of thymocytes has been demonstrated. ..
  8. Perez Martinez M, Gordón Alonso M, Cabrero J, Barrero Villar M, Rey M, Mittelbrunn M, et al. F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse. J Cell Sci. 2010;123:1160-70 pubmed publisher
    ..Our data indicate that drebrin exerts an unexpected and relevant functional role in T cells during the generation of the immune response. ..
  9. Friedrichs J, Helenius J, Muller D. Stimulated single-cell force spectroscopy to quantify cell adhesion receptor crosstalk. Proteomics. 2010;10:1455-62 pubmed publisher
    ..The single-cell assay should be expandable for the screening and quantification of crosstalk between various cell adhesion molecules and other cell surface receptors. ..
  10. Hwangbo C, Kim J, Lee J, Lee J. Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. Cancer Res. 2010;70:1645-55 pubmed publisher
    ..In summary, our findings offer evidence that mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human breast cancer and melanoma cells. ..
  11. Kaarbø M, Klokk T, Saatcioglu F. Androgen signaling and its interactions with other signaling pathways in prostate cancer. Bioessays. 2007;29:1227-38 pubmed
    ..This complex network of interactions is providing a deeper insight into prostate carcinogenesis and may form the basis for novel diagnostic and therapeutic strategies. ..
  12. Wang G, Wang J, Sadar M. Crosstalk between the androgen receptor and beta-catenin in castrate-resistant prostate cancer. Cancer Res. 2008;68:9918-27 pubmed publisher
    ..These studies provide the first in vivo evidence to support aberrant activation of the AR through the Wnt/beta-catenin signaling pathway during progression of prostate cancer to the terminal castrate-resistant stage...
  13. Koornneef A, Leon Reyes A, Ritsema T, Verhage A, Den Otter F, Van Loon L, et al. Kinetics of salicylate-mediated suppression of jasmonate signaling reveal a role for redox modulation. Plant Physiol. 2008;147:1358-68 pubmed publisher
    ..The glutathione biosynthesis inhibitor l-buthionine-sulfoximine strongly reduced PDF1.2 suppression by SA, suggesting that SA-mediated redox modulation plays an important role in the SA-mediated attenuation of the JA signaling pathway. ..
  14. Nocito F, Espen L, Fedeli C, Lancilli C, Musacchi S, Serra S, et al. Oxidative stress and senescence-like status of pear calli co-cultured on suspensions of incompatible quince microcalli. Tree Physiol. 2010;30:450-8 pubmed publisher
    ..Taken as a whole, physiological and molecular data strongly suggest that undifferentiated cells belonging to a pear graft-incompatible quince clone may induce an early senescence-like status in a closely co-cultured pear callus. ..
  15. GRAHAM T, Yacoub R, Taliaferro Smith L, Osunkoya A, Odero Marah V, Liu T, et al. Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells. Breast Cancer Res Treat. 2010;123:139-47 pubmed publisher
    ..Taken together, these results indicate that ZEB1 and AR regulate each other to promote cell migration in triple negative breast cancer cells. ..
  16. Wang M, Krauss J, Domon H, Hosur K, Liang S, Magotti P, et al. Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal. 2010;3:ra11 pubmed publisher
  17. Beck I, Vanden Berghe W, Vermeulen L, Yamamoto K, Haegeman G, De Bosscher K. Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev. 2009;30:830-82 pubmed publisher
  18. Ohtake F, Fujii Kuriyama Y, Kato S. AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochem Pharmacol. 2009;77:474-84 pubmed publisher
    ..We propose that target-specific regulation of protein destruction, as well as gene expression, is modulated by environmental toxins through the E3 ubiquitin ligase activity of AhR. ..
  19. Rodríguez Lagunas M, Martín Venegas R, Moreno J, Ferrer R. PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers. Am J Physiol Cell Physiol. 2010;299:C324-34 pubmed publisher
  20. Guo X, Wang X. Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res. 2009;19:71-88 pubmed publisher
  21. Baena Gonzalez E, Sheen J. Convergent energy and stress signaling. Trends Plant Sci. 2008;13:474-82 pubmed publisher
  22. Kambayashi T, LaRosa D, Silverman M, Koretzky G. Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunol Rev. 2009;232:99-114 pubmed publisher
    ..Deciphering the molecular mechanisms leading to mast cell activation will hopefully bring new ideas for the development of novel therapeutics to control allergic diseases. ..
  23. Petty J, Lenox C, Weiss D, Poynter M, Suratt B. Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow. J Immunol. 2009;182:604-12 pubmed
  24. Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Forster R. CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood. 2010;115:1906-12 pubmed publisher
    ..In turn, CCR7 signals can partially compensate for CCR9 signals, thus explaining the rather mild phenotype of CCR9(-/-) mice with respect to progenitor seeding. ..
  25. Francesco A, Diego G, Susanna G, Giuseppina L, Amina W, Sergi F, et al. Integrative action of receptor mosaics: relevance of receptor topology and allosteric modulators. J Recept Signal Transduct Res. 2008;28:543-65 pubmed publisher
    ..We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders. ..
  26. Schayowitz A, Sabnis G, Goloubeva O, Njar V, Brodie A. Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR. Br J Cancer. 2010;103:1001-7 pubmed publisher
    ..Furthermore, after bicalutamide failure, dual inhibition with VN/124-1 and everolimus was the most effective treatment. ..
  27. Kung T, Murphy K, White L. The aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism. Biochem Pharmacol. 2009;77:536-46 pubmed publisher
    ..In addition, we will discuss evidence suggesting that the AhR pathway is responsive to changes in matrix composition as well as cell-cell and cell-matrix interactions. ..
  28. Kzhyshkowska J, Krusell L. Cross-talk between endocytic clearance and secretion in macrophages. Immunobiology. 2009;214:576-93 pubmed publisher
    ..We propose novel level of regulation for the secretory repertoire of macrophages: cross-talk of uptake and release at the level of vesicular trafficking. ..
  29. Zhai Y, Wada T, Zhang B, Khadem S, Ren S, Kuruba R, et al. A functional cross-talk between liver X receptor-? and constitutive androstane receptor links lipogenesis and xenobiotic responses. Mol Pharmacol. 2010;78:666-74 pubmed publisher
    ..In conclusion, our results have revealed dual functions of LXR? and CAR in lipogenesis and xenobiotic responses, establishing a unique role of these two receptors in integrating xenobiotic and endobiotic homeostasis. ..
  30. Jones B, Logsdon N, Walter M. Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:266-9 pubmed publisher
    ..43, b = 76.33, c = 114.92 A, beta = 92.45 degrees , and diffracted X-rays to 3.2 A resolution. The crystallographic asymmetric unit contained two IL-22-sIL-22R1 complexes, corresponding to a solvent content of approximately 52%. ..
  31. Sautina L, Sautin Y, Beem E, Zhou Z, Schuler A, Brennan J, et al. Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2. Blood. 2010;115:896-905 pubmed publisher
    ..This is the first definitive functional and structural evidence of an interaction between the 2 receptors and has implications for the side effects of EPO. ..
  32. Jerez S, Sierra L, Scacchi F, Peral de Bruno M. Hypercholesterolemia modifies angiotensin II desensitisation and cross talk between alpha(1)-adrenoceptor and angiotensin AT(1) receptor in rabbit aorta. Eur J Pharmacol. 2010;635:149-55 pubmed publisher
    ..This may be one of the mechanisms by which hypercholesterolemia could be involved in the onset and progression of chronic vascular diseases such as hypertension and arteriosclerosis. ..
  33. Millan M, Marin P, Bockaert J, Mannoury La Cour C. Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends Pharmacol Sci. 2008;29:454-64 pubmed publisher
    ..In view of the diversity of transduction mechanisms engaged by 5-HT, much of this discussion is relevant to other classes of G-protein-coupled receptors. ..
  34. Wieduwilt M, Moasser M. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci. 2008;65:1566-84 pubmed publisher
    ..Here we review the biology of ErbB receptors, including their structure, signaling, regulation, and roles in development and disease, then briefly touch on their increasing roles as targets for cancer therapy. ..
  35. Melki M, Saidi H, Dufour A, Olivo Marin J, Gougeon M. Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1. PLoS Pathog. 2010;6:e1000862 pubmed publisher
  36. Gutknecht E, Vauquelin G, Dautzenberg F. Corticotropin-releasing factor receptors induce calcium mobilization through cross-talk with Gq-coupled receptors. Eur J Pharmacol. 2010;642:1-9 pubmed publisher
    ..The results suggest that stimulating a Gq-coupled receptor shortly before stimulating a Gs-coupled receptor may result in a parallel signaling event on top of the classical cyclic AMP pathway. ..
  37. Li L, Leung D, Martin R, Goleva E. Inhibition of histone deacetylase 2 expression by elevated glucocorticoid receptor beta in steroid-resistant asthma. Am J Respir Crit Care Med. 2010;182:877-83 pubmed publisher
    ..This highlights a novel mechanism by which glucocorticoid receptor ? promotes steroid insensitivity (Li et al.: J Allergy Clin Immunol 2009;123:S146; and Li et al.: J Allergy Clin Immunol 2010;125:AB104). ..
  38. Zhao A, Alvin Z, Laurence G, Li C, Haddad G. Cross-talk between MAPKs and PI-3K pathways alters the functional density of I(K) channels in hypertrophied hearts. Ethn Dis. 2010;20:S1-219-24 pubmed
    ..This is true in African Americans, having higher circulating IGF-1 levels, and especially true for the athletes among them. ..
  39. Reikvam H, Hatfield K, Lassalle P, Kittang A, Ersvaer E, Bruserud Ø. Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release. Expert Opin Investig Drugs. 2010;19:169-83 pubmed publisher
    ..We conclude that various strategies for inhibition of Tie-2-mediated signalling should be considered in AML therapy, possibly in combination with other antiangiogenic strategies. ..
  40. Wihlén B, Ahmed S, Inzunza J, Matthews J. Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription. Mol Cancer Res. 2009;7:977-86 pubmed publisher
    ..These results establish ligand- and promoter-specific influences on the cyclical recruitment patterns for AHR and show ER species-, subtype-, and promoter-specific modulation of AHR-dependent transcription. ..
  41. Barbieri R, Alloisio S, Ferroni S, Nobile M. Differential crosstalk between P2X7 and arachidonic acid in activation of mitogen-activated protein kinases. Neurochem Int. 2008;53:255-62 pubmed publisher
    ..The result that ERK1/2-mediated transduction pathway is synergistically modulated by ATP and AA signalling depicts possible novel pharmacological targets for interfering with pathological activation of astroglial cells. ..
  42. Petrunich M, Garcia F, Carrasco G, Battaglia G. Prolonged 5-HT1A/5-HT2A receptor cross-talk is absent prior to adulthood in rats. Neuroreport. 2008;19:1457-61 pubmed publisher
    ..These data suggest that 5-HT1A heterologous desensitization of 5-HT2A receptor function does not develop until adulthood, is more transient, or follows a different time course before maturation. ..
  43. Kohle C, Bock K. Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor. Biochem Pharmacol. 2009;77:689-99 pubmed publisher
    ..Biotransformation appears to be tightly controlled to achieve efficient homeostasis of endobiotics and detoxification of dietary phytochemicals, but nuclear receptor agonists may also lead to potentially harmful drug interactions. ..
  44. Tokay T, Hachem R, Masmoudi Kouki O, Gandolfo P, Desrues L, Leprince J, et al. Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N-formyl peptide receptors. Glia. 2008;56:1380-9 pubmed publisher
    ..Taken together, these data demonstrate for the first time that Abeta(25-35) stimulates endozepine release from rat astrocytes through a FPR receptor positively coupled to PKA and PKC. ..
  45. Kotlo K, Rasenick M, Danziger R. Evidence for cross-talk between atrial natriuretic peptide and nitric oxide receptors. Mol Cell Biochem. 2010;338:183-9 pubmed publisher
    ..In summary, the results show that NOGCbeta1 and GC-A interact and that NOGCbeta1 regulates ANP signaling in HK-2 cells. The results raise the novel possibility of cross-talk between NOGC and GC-A signaling pathways in membrane caveolae. ..
  46. Naumenko V, Bazovkina D, Kondaurova E, Zubkov E, Kulikov A. The role of 5-HT2A receptor and 5-HT2A/5-HT1A receptor interaction in the suppression of catalepsy. Genes Brain Behav. 2010;9:519-24 pubmed publisher
    ..Thus, 5-HT(2A)/5-HT(1A) receptor interaction in the mechanism of catalepsy suppression in mice was shown. ..
  47. Guy C, Vignali D. Organization of proximal signal initiation at the TCR:CD3 complex. Immunol Rev. 2009;232:7-21 pubmed publisher
    ..Rather than simply signal initiation, individual ITAMs may also be responsible for the differential recruitment of signaling and regulatory molecules which ultimately affects T-cell development, activation and differentiation. ..
  48. Wang Y, Weil B, Herrmann J, Abarbanell A, Tan J, Markel T, et al. MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells. Am J Physiol Cell Physiol. 2009;297:C1284-93 pubmed publisher
  49. Kim D, Jeoung D, Ro J. Signaling pathways in the activation of mast cells cocultured with astrocytes and colocalization of both cells in experimental allergic encephalomyelitis. J Immunol. 2010;185:273-83 pubmed publisher
  50. Colomiere M, Ward A, Riley C, Trenerry M, Cameron Smith D, Findlay J, et al. Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br J Cancer. 2009;100:134-44 pubmed publisher
    ..Such activation of STAT3 suggests a rationale for a combination of anti-STAT3 and EGFR/IL-6R therapy to suppress the peritoneal spread of ovarian cancer. ..
  51. Festuccia C, Gravina G, Muzi P, Millimaggi D, Dolo V, Vicentini C, et al. Her2 crosstalks with TrkA in a subset of prostate cancer cells: rationale for a guided dual treatment. Prostate. 2009;69:337-45 pubmed publisher
    ..Our data suggest that the dual inhibition of TrkA and Her2 may be useful in a subset of patients in which TrkA and Her2 are overexpressed and in which the possibility of TrkA and Her2 protein-binding is elevated. ..
  52. Hudson B, Hebert T, Kelly M. Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors. Br J Pharmacol. 2010;160:627-42 pubmed publisher
    ..As similar functional interactions were also observed in HTM cells, such interactions may affect the pharmacology of these receptors in tissues where they are endogenously co-expressed. ..
  53. Borlak J, Jenke H. Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. Mol Cancer Res. 2008;6:1326-36 pubmed publisher
    ..Taken collectively, we show AhR to be a master regulator of c-raf and propose cross-talk between AhR and the mitogen-activated protein kinase signaling pathway in chemically induced hepatocarcinogenesis. ..