mitochondrial dynamics


Summary: The continuous remodeling of MITOCHONDRIA shape by fission and fusion in response to physiological conditions.

Top Publications

  1. Marcu R, Zheng Y, Hawkins B. Mitochondria and Angiogenesis. Adv Exp Med Biol. 2017;982:371-406 pubmed publisher
    ..We also focus on recent findings identifying mitochondrial targeting compounds that exhibit pro-angiogenic or anti-angiogenic properties, and could therefore be of clinical importance for the treatment of vascular pathologies. ..
  2. Ding M, Dong Q, Liu Z, Liu Z, Qu Y, Li X, et al. Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice. Cardiovasc Diabetol. 2017;16:19 pubmed publisher
    ..Pharmacological inhibition of Drp1 prevents mitochondrial fission and reduces MI/R injury in diabetic mice. The findings suggest Drp1 may be a potential novel therapeutic target for diabetic cardiac complications. ..
  3. Sobral L, Coletta R, Alberici L, Curti C, Leopoldino A. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS J. 2017;284:2774-2785 pubmed publisher
    ..Overall, our results show that SEToverexpression promotes morphological and oncogenic cell transformation of an oral keratinocyte cell. ..
  4. Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, et al. Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin. Nat Cell Biol. 2017;19:856-863 pubmed publisher
    ..Thus, multiple OPA1 functions are modulated by local CL conditions for regulation of mitochondrial morphology and quality control. ..
  5. Chauhan A, Vera J, Wolkenhauer O. The systems biology of mitochondrial fission and fusion and implications for disease and aging. Biogerontology. 2014;15:1-12 pubmed
    ..This will help us to understand how different regulatory mechanisms regulate the ATP and mutation (mtDNA) landscape of mitochondria to a variety of environmental stimuli in order to maintain their function during aging. ..
  6. Liu R, Chan D. OPA1 and cardiolipin team up for mitochondrial fusion. Nat Cell Biol. 2017;19:760-762 pubmed publisher
    ..A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome. ..
  7. Jin X, Wang J, Gao K, Zhang P, Yao L, Tang Y, et al. Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer. PLoS Genet. 2017;13:e1006748 pubmed publisher
    ..reveal novel molecular events underlying the regulation of INF2 function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer.
  8. Gonzalez Franquesa A, Patti M. Insulin Resistance and Mitochondrial Dysfunction. Adv Exp Med Biol. 2017;982:465-520 pubmed publisher
    ..In this chapter, we will present the evidence linking mitochondrial dysfunction and insulin resistance, and review the potential for mitochondrial targets as a therapeutic approach for T2D. ..
  9. Sebastian D, Palacin M, Zorzano A. Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging. Trends Mol Med. 2017;23:201-215 pubmed publisher
    ..b>Mitochondrial dynamics is a key process regulating mitochondrial function and quality...

More Information


  1. Facundo H, Brainard R, Caldas F, Lucas A. Mitochondria and Cardiac Hypertrophy. Adv Exp Med Biol. 2017;982:203-226 pubmed publisher
  2. Huang Q, Cao H, Zhan L, Sun X, Wang G, Li J, et al. Mitochondrial fission forms a positive feedback loop with cytosolic calcium signaling pathway to promote autophagy in hepatocellular carcinoma cells. Cancer Lett. 2017;403:108-118 pubmed publisher
  3. Torrealba N, Aranguiz P, Alonso C, Rothermel B, Lavandero S. Mitochondria in Structural and Functional Cardiac Remodeling. Adv Exp Med Biol. 2017;982:277-306 pubmed publisher
    ..Here we will also review strategies to improve mitochondrial function and discuss their cardioprotective potential. ..
  4. Ni Z, Tao L, Xiaohui X, Zelin Z, Jiangang L, Zhao S, et al. Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression. J Cell Physiol. 2017;232:2776-2787 pubmed publisher
    ..In conclusion, we demonstrate that PD may be therapeutically useful in DN, and that, podocyte apoptosis induced by HG can be reversed by PD through suppressing Drp1 expression. ..
  5. Ong S, Kalkhoran S, Hernández Reséndiz S, Samangouei P, Ong S, Hausenloy D. Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!. Cardiovasc Drugs Ther. 2017;31:87-107 pubmed publisher
    ..In this review article, we provide an overview of the mitochondrial fusion and fission proteins in the adult heart, and highlight their roles as novel therapeutic targets for treating cardiac disease. ..
  6. Ji W, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs H. Receptor-mediated Drp1 oligomerization on endoplasmic reticulum. J Cell Biol. 2017;216:4123-4139 pubmed publisher
    ..Our results suggest that ER can function as a platform for Drp1 oligomerization, and that ER-associated Drp1 contributes to mitochondrial division. ..
  7. Liu Y, Yan Y, Inagaki Y, Logan S, Bosnjak Z, Bai X. Insufficient Astrocyte-Derived Brain-Derived Neurotrophic Factor Contributes to Propofol-Induced Neuron Death Through Akt/Glycogen Synthase Kinase 3?/Mitochondrial Fission Pathway. Anesth Analg. 2017;125:241-254 pubmed publisher
  8. Nan J, Zhu W, Rahman M, Liu M, Li D, Su S, et al. Molecular regulation of mitochondrial dynamics in cardiac disease. Biochim Biophys Acta Mol Cell Res. 2017;1864:1260-1273 pubmed publisher
    ..Mitochondrial fission and fusion (mitochondrial dynamics) play essential roles in maintaining mitochondrial homeostasis, defects in mitochondrial dynamics lead to ..
  9. Duann P, Lin P. Mitochondria Damage and Kidney Disease. Adv Exp Med Biol. 2017;982:529-551 pubmed publisher
    ..A better understanding of the cellular and molecular events that govern mitochondria functions in health and disease will potentially lead to improved therapeutics development. ..
  10. Crouser E. Autophagy, the first step towards recovery from critical illness. Crit Care Med. 2013;41:358-9 pubmed publisher
  11. Sheeran F, Pepe S. Mitochondrial Bioenergetics and Dysfunction in Failing Heart. Adv Exp Med Biol. 2017;982:65-80 pubmed publisher
  12. Kurz F, Aon M, O ROURKE B, Armoundas A. Functional Implications of Cardiac Mitochondria Clustering. Adv Exp Med Biol. 2017;982:1-24 pubmed publisher
    ..g., ischemia-reperfusion). This underscores the relevance of quantitative methods to characterize the network's functional status as a way to assess the myocyte's resilience to pathological stressors. ..
  13. Lv F, Yang X, Cui C, Su C. Exogenous expression of Drp1 plays neuroprotective roles in the Alzheimer's disease in the A?42 transgenic Drosophila model. PLoS ONE. 2017;12:e0176183 pubmed publisher
    ..The protective effect of Drp1 on the A?42 transgenic Drosophila was achieved by protecting the mitochondrial function, suggesting that Drp1 may be a potential therapeutic strategies for AD. ..
  14. Morigi M, Perico L, Rota C, Longaretti L, Conti S, Rottoli D, et al. Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. J Clin Invest. 2015;125:715-26 pubmed publisher
    ..Together, our results indicate that SIRT3 is protective against AKI and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury.
  15. Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell. 2017;67:922-935.e5 pubmed publisher
    ..These data provide direct evidence for cell survival upon mTOR inhibition through mitochondrial hyperfusion employing MTFP1 as a critical effector of mTORC1 to govern cell fate decisions. ..
  16. Han B, Sivaramakrishnan P, Lin C, Neve I, He J, Tay L, et al. Microbial Genetic Composition Tunes Host Longevity. Cell. 2017;169:1249-1262.e13 pubmed publisher
    ..promote longevity through increased secretion of the polysaccharide colanic acid (CA), which regulates mitochondrial dynamics and unfolded protein response (UPRmt) in the host...
  17. Luz A, Godebo T, Smith L, Leuthner T, Maurer L, Meyer J. Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Toxicology. 2017;387:81-94 pubmed publisher
    ..This research demonstrates the importance of mitochondrial dynamics in limiting arsenite toxicity by permitting mitochondrial adaptability...
  18. Das S, Vasanthi H, Parjapath R. MitomiRs Keep the Heart Beating. Adv Exp Med Biol. 2017;982:431-450 pubmed publisher
    ..We term this subset of miRNAs as "MitomiRs". ..
  19. Ko A, Kang T. TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation. Neuropharmacology. 2017;121:120-129 pubmed publisher
    ..These findings indicate that TRPC6 may regulate mitochondrial dynamics via ERK1/2-mediaed DRP1 activation, which would be involved in DGC invulnerability to SE...
  20. Pan S, Sharma P, Shah S, Deshpande D. Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2017;313:L154-L165 pubmed publisher
  21. Ikon N, Ryan R. Cardiolipin and mitochondrial cristae organization. Biochim Biophys Acta Biomembr. 2017;1859:1156-1163 pubmed publisher
    ..Once established, cristae ultrastructure has a direct impact on oxidative phosphorylation, apoptosis, fusion/fission as well as diseases of compromised energy metabolism. ..
  22. Barel O, Malicdan M, Ben Zeev B, Kandel J, Pri Chen H, Stephen J, et al. Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy. Brain. 2017;140:568-581 pubmed publisher
    ..This study confirms the role of TRAK1 in mitochondrial dynamics and constitutes the first report of this gene in association with a severe neurodevelopmental disorder.
  23. Li J, Huang Q, Long X, Guo X, Sun X, Jin X, et al. Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress. Oncogene. 2017;36:4901-4912 pubmed publisher
    ..Overall, our study demonstrates that remodelling of mitochondrial morphology plays a critical role in tumour cell adaptation to energy stress by reprogramming glucose metabolism. ..
  24. Zheng X, Chen M, Meng X, Chu X, Cai C, Zou F. Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis. Mol Immunol. 2017;87:23-32 pubmed publisher
    ..Thus, our study identifies the dependence of neutrophil polarization and chemotaxis on the MCU and highlights the importance of regulating mitochondrial fission during the anti-inflammatory cascade in human neutrophils. ..
  25. Lyons A, Coleman M, Riis S, Favre C, O Flanagan C, Zhdanov A, et al. Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells. J Biol Chem. 2017;292:16983-16998 pubmed publisher
    ..This core mitochondrial protective signal is likely to strongly influence responses to therapy and the phenotypic evolution of cancer. ..
  26. Prakasam G, Singh R, Iqbal M, Saini S, Tiku A, Bamezai R. Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival. J Biol Chem. 2017;292:15561-15576 pubmed publisher
    ..On the basis of our observations, we propose an alternative therapeutic strategy of silencing either of the PKM isoforms along with AMPK in tumors. ..
  27. Flippo K, Strack S. Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci. 2017;130:671-681 pubmed publisher
    ..b>Mitochondrial dynamics, a collective term for the processes of mitochondrial fission, fusion and transport, governs mitochondrial ..
  28. Sorriento D, Gambardella J, Fiordelisi A, Trimarco B, Ciccarelli M, Iaccarino G, et al. Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness. Adv Exp Med Biol. 2017;982:521-528 pubmed publisher
    ..Here we examine the mechanistic role of cellular kinases in the fine regulation of key mitochondrial activities, including mitochondrial quality control, fission/fusion processes, metabolism, and mitophagy. ..
  29. Sanchis Gomar F, Derbré F. Mitochondrial fission and fusion in human diseases. N Engl J Med. 2014;370:1073-4 pubmed publisher
  30. Kathayat R, Cao Y, Elvira P, Sandoz P, Zaballa M, Springer M, et al. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun. 2018;9:334 pubmed publisher
    ..Altogether, this work reveals that mitochondrial S-palmitoylation is actively regulated by "eraser" enzymes that respond to alterations in mitochondrial lipid homeostasis. ..
  31. Zhang X, Chen W, Li J, Qi S, Hong S, Wang Y, et al. Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension. Biochem Biophys Res Commun. 2018;495:454-460 pubmed publisher
    ..Our data indicate that CaSR-mediated mitochondrial fission could be a therapeutic target for hyperproliferative disorders. ..
  32. Burman J, Pickles S, Wang C, Sekine S, Vargas J, Zhang Z, et al. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. J Cell Biol. 2017;216:3231-3247 pubmed publisher
    ..These results are consistent with a new model that, instead of promoting mitophagy, fission protects healthy mitochondrial domains from elimination by unchecked PINK1-Parkin activity. ..
  33. Nan J, Hu H, Sun Y, Zhu L, Wang Y, Zhong Z, et al. TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circ Res. 2017;121:392-410 pubmed publisher
    ..This process was facilitated by p300-mediated Stat3 acetylation and Stat3/RelA interactions, leading to improvements in mitochondrial morphology and function. ..
  34. Böckler S, Chelius X, Hock N, Klecker T, Wolter M, Weiss M, et al. Fusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates. J Cell Biol. 2017;216:2481-2498 pubmed publisher
    ..Together, these data suggest that coordination of mitochondrial transport, fusion, and fission is critical for asymmetric division and rejuvenation of daughter cells. ..
  35. Park J, Min J, Chae U, Lee J, Song K, Lee H, et al. Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission. J Neuroimmunol. 2017;306:46-52 pubmed publisher
    ..Our findings suggest a potential role of oleuropein in microglial inflammation-mediated neurodegenerative disorders. ..
  36. Jin X, Xu Z, Zhao X, Chen M, Xu S. The antagonistic effect of selenium on lead-induced apoptosis via mitochondrial dynamics pathway in the chicken kidney. Chemosphere. 2017;180:259-266 pubmed publisher
    ..The aim of this study was to evaluate the roles of mitochondrial dynamics on Pb-induced apoptosis in the chicken kidney and investigate the antagonistic effect of Se...
  37. Wang Y, Subramanian M, Yurdagul A, Barbosa Lorenzi V, Cai B, de Juan Sanz J, et al. Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017;171:331-345.e22 pubmed publisher
    ..Thus, mitochondrial fission in response to AC uptake is a critical process that enables macrophages to clear multiple ACs and to avoid the pathologic consequences of defective efferocytosis in vivo. ..
  38. Ryan J, Archer S. Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension. Circulation. 2015;131:1691-702 pubmed publisher
  39. Yang Y, Li J, Liu K, Zhang L, Liu Q, Liu B, et al. Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1. Cell Death Dis. 2017;8:e2625 pubmed publisher
  40. Zhang L, Gan X, He Y, Zhu Z, Zhu J, Yu H. Drp1-dependent mitochondrial fission mediates osteogenic dysfunction in inflammation through elevated production of reactive oxygen species. PLoS ONE. 2017;12:e0175262 pubmed publisher
  41. Zhou X, Han T, Chen H, Baker P, Qi H, Zhang H. Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia. Exp Cell Res. 2017;359:195-204 pubmed publisher
    ..Furthermore, we revealed abnormal regulation of mitochondrial dynamics, autophagy, and biogenesis in sPE...
  42. Hoppel C, Lesnefsky E, Chen Q, Tandler B. Mitochondrial Dysfunction in Cardiovascular Aging. Adv Exp Med Biol. 2017;982:451-464 pubmed publisher
    ..Because these cardiac health issues are localized to specific mitochondria, these organelles offer potential targets for therapeutic approaches that could favorably affect the aging process in heart. ..
  43. Williams E, Chen X, Moore D. VPS35, the Retromer Complex and Parkinson's Disease. J Parkinsons Dis. 2017;7:219-233 pubmed publisher
    ..e. ?-synuclein, LRRK2 and parkin) in PD. Present data support a role for perturbed VPS35 and retromer function in the pathogenesis of PD. ..
  44. Cloonan S, Choi A. Mitochondria in lung disease. J Clin Invest. 2016;126:809-20 pubmed publisher
  45. Chaudhari S, Kipreos E. Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways. Nat Commun. 2017;8:182 pubmed publisher
    Mitochondria are dynamic organelles that undergo fusion and fission events. Mitochondrial dynamics are required for mitochondrial viability and for responses to changes in bioenergetic status...
  46. Liu X, Wang W, Song G, Wei X, Zeng Y, Han P, et al. Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. PLoS ONE. 2017;12:e0182558 pubmed publisher
    ..In conclusion, administration of AS-IV could retard DN progression in type 2 diabetes mice, which might be associated with restoration of the mitochondrial quality control network. ..
  47. Carrascoso I, Alcalde J, Sánchez Jiménez C, González Sánchez P, Izquierdo J. T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression. Mol Cell Biol. 2017;37: pubmed publisher
    ..Collectively, these results provide molecular insights into the antagonistic functions of TIA1b/TIARb and HuR in mitochondrial activity dynamics and suggest that their balance might contribute to mitochondrial physiopathology. ..
  48. Zhang G, Frederick D, Wu L, Wei Z, Krepler C, Srinivasan S, et al. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. J Clin Invest. 2016;126:1834-56 pubmed publisher
    ..Our study establishes mitochondrial biogenesis, coupled with aberrant tumor bioenergetics, as a potential therapy escape mechanism and paves the way for a rationale-based combinatorial strategy to improve the efficacy of MAPKi. ..
  49. White C, Datta G, Giordano S. High-Density Lipoprotein Regulation of Mitochondrial Function. Adv Exp Med Biol. 2017;982:407-429 pubmed publisher
    ..This chapter examines the role of HDL-associated apolipoproteins and lipids in the regulation of mitochondrial function and bioenergetics. ..
  50. Vartanian V, Tumová J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd R, et al. 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle. PLoS ONE. 2017;12:e0181687 pubmed publisher
    ..Collectively, these data indicate a role for skeletal muscle OGG1 in the maintenance of optimal tissue function. ..
  51. Yu T, Zhang Y, Li P. Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders. Adv Exp Med Biol. 2017;982:327-333 pubmed publisher
    b>Mitochondrial dynamics play a critical role in cellular responses and physiological process...
  52. Archer S. Mitochondrial dynamics--mitochondrial fission and fusion in human diseases. N Engl J Med. 2013;369:2236-51 pubmed publisher
  53. Adams K. Genomics. Genomic clues to the ancestral flowering plant. Science. 2013;342:1456-7 pubmed publisher
  54. Masson J, Murphy A, Lee M, Ostrowski M, Crowe S, Palmer C. Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy. PLoS ONE. 2017;12:e0183931 pubmed publisher
    ..There were no significant differences in mitochondrial dynamics between subject groups...
  55. Kwon D, Park E, Sesaki H, Kang S. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017;493:737-743 pubmed publisher
    ..Our findings highlight the coupling of the STING signaling platform to mitochondria dynamics. ..
  56. Jiang C, Xie C, Li F, Zhang L, Nichols R, Krausz K, et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest. 2015;125:386-402 pubmed publisher
    ..This work suggests that inhibition of intestinal FXR is a potential therapeutic target for NAFLD treatment. ..
  57. Lee H, Smith S, Yoon Y. The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure. J Biol Chem. 2017;292:7115-7130 pubmed publisher
    ..Our results demonstrate that, contrary to conventional notion, S-OPA1 is fully competent for maintaining mitochondrial energetics and cristae structure. ..
  58. Gerber S, Charif M, Chevrollier A, Chaumette T, Angebault C, Kane M, et al. Mutations in DNM1L, as in OPA1, result in dominant optic atrophy despite opposite effects on mitochondrial fusion and fission. Brain. 2017;140:2586-2596 pubmed publisher
  59. Szafranski P. Evolutionarily recent, insertional fission of mitochondrial cox2 into complementary genes in bilaterian Metazoa. BMC Genomics. 2017;18:269 pubmed publisher
    ..The reported data also indicate that bilaterian animal mitogenomes may be carrying lineage-specific genes more often than previously thought, and suggest a homing endonuclease-based mechanism for insertional mitochondrial gene fission. ..
  60. Kandimalla R, Manczak M, Fry D, Suneetha Y, Sesaki H, Reddy P. Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease. Hum Mol Genet. 2016;25:4881-4897 pubmed publisher
    ..and immunostaining analyses, we measured mRNA expressions and protein levels of genes related to the mitochondrial dynamics—Drp1 and Fis1 (fission), Mfn1, Mfn2 and Opa1 (fusion), CypD (matrix), mitochondrial biogenesis—Nrf1, ..
  61. Lin C, Wang M. Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling. Nat Cell Biol. 2017;19:550-557 pubmed publisher
    ..Here, we discovered that environmental methionine tunes bacterial methyl metabolism to regulate host mitochondrial dynamics and lipid metabolism in Caenorhabditis elegans through an endocrine crosstalk involving NR5A nuclear ..
  62. Viana Huete V, Guillén C, García G, Fernández S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed publisher
    ..Collectively, our data suggest a cause-and-effect relationship between failure in brown fat thermogenesis and increased adiposity and obesity. ..