mitochondrial turnover


Summary: The cellular processes involved in adjustments to the MITOCHONDRIAL VOLUME, content, and activity, that depend on the energy demands of the cell.

Top Publications

  1. Cooper M. Interplay of mitochondrial biogenesis and oxidative stress in heart failure. Circulation. 2013;127:1932-4 pubmed publisher
  2. Dominy J, Puigserver P. Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol. 2013;5: pubmed publisher
    ..This regulatory network represents a new therapeutic window into the treatment of the wide spectrum of mitochondrial and neurodegenerative diseases characterized by dysregulation of mitochondrial dynamics and bioenergetic deficiencies. ..
  3. Ho L, Titus A, Banerjee K, George S, Lin W, Deota S, et al. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013;5:835-49 pubmed
    ..This study highlights the ability of Sirt4 to regulate ATP levels via ANT2 and a feedback loop involving AMPK. ..
  4. Dolezal J, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, et al. Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma. J Biol Chem. 2017;292:10068-10086 pubmed publisher
    ..Collectively, these studies define the metabolic, biochemical, and molecular events accompanyingHCCevolution, regression, and recurrence in the absence of any potentially confounding therapies. ..
  5. Wang X, Luo Y, Wang D, Adorini L, Pruzanski M, Dobrinskikh E, et al. A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice. J Biol Chem. 2017;292:12018-12024 pubmed publisher
    ..In summary, our results indicate that FXR and TGR5 may play an important role in modulation of age-related kidney disease. ..
  6. Morrish F, Hockenbery D. MYC and mitochondrial biogenesis. Cold Spring Harb Perspect Med. 2014;4: pubmed publisher
    ..As an oncogene, MYC also presents intriguing questions about the role of its mitochondrial targets in cancer-related phenotypes, such as the Warburg effect and MYC-dependent apoptosis. ..