transcytosis

Summary

Summary: The transport of materials through a cell. It includes the uptake of materials by the cell (ENDOCYTOSIS), the movement of those materials through the cell, and the subsequent secretion of those materials (EXOCYTOSIS).

Top Publications

  1. Sripada L, Singh K, Lipatova A, Singh A, Prajapati P, Tomar D, et al. hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells. J Mol Med (Berl). 2017;95:641-651 pubmed publisher
    ..We conclude that the mitochondria-targeted miR-4485 may act as a tumor suppressor in breast carcinoma cells by negatively regulating mitochondrial RNA processing and mitochondrial functions. ..
  2. Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
    ..Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all ..
  3. Sly W, Vogler C. The final frontier -- crossing the blood-brain barrier. EMBO Mol Med. 2013;5:655-7 pubmed publisher
  4. Clairembault T, Leclair Visonneau L, Coron E, Bourreille A, Le Dily S, Vavasseur F, et al. Structural alterations of the intestinal epithelial barrier in Parkinson's disease. Acta Neuropathol Commun. 2015;3:12 pubmed publisher
    ..Our findings provide evidence that the IEB is morphologically altered in PD and further reinforce the potential role of the gastrointestinal tract in the initiation and/or the progression of the disease. ..
  5. Storck S, Meister S, Nahrath J, Meißner J, Schubert N, Di Spiezio A, et al. Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier. J Clin Invest. 2016;126:123-36 pubmed publisher
    ..Together, our results suggest that receptor-mediated Aβ BBB clearance may be a potential target for treatment and prevention of Aβ brain accumulation in AD. ..
  6. Stewart T, Koval W, Molina S, Bock S, Lillard J, Ross R, et al. Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Exp Cell Res. 2017;355:153-161 pubmed publisher
    ..These data suggested that NSFs stimulate an active transport pathway, most likely transcytosis, in addition to increasing paracellular flux...
  7. Andreone B, Chow B, Tata A, Lacoste B, Ben Zvi A, Bullock K, et al. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017;94:581-594.e5 pubmed publisher
    ..An unusually low rate of vesicular transport (transcytosis) has been identified as one of the two unique properties of CNS endothelial cells, relative to peripheral ..
  8. Lisney A, Szelinski F, Reiter K, Burmester G, Rose T, Dorner T. High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block. Ann Rheum Dis. 2017;76:1476-1480 pubmed publisher
    Autoimmune congenital heart block (CHB) is associated with placental transcytosis of maternal autoantibodies directed against Ro/SS-A and La/SS-B...
  9. Beloqui A, Brayden D, Artursson P, Préat V, des Rieux A. A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation. Nat Protoc. 2017;12:1387-1399 pubmed publisher
    ..The protocol requires skills in cell culture and microscopy analysis. The model is obtained after 3 weeks, and transport experiments across the differentiated model can be carried out over periods of up to 10 h. ..

More Information

Publications10

  1. Yamashita N, Joshi R, Zhang S, Zhang Z, Kuruvilla R. Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors. Dev Cell. 2017;42:626-639.e5 pubmed publisher
    ..we report that retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons, and we define the molecular underpinnings of this positive feedback ..