exocytosis

Summary

Summary: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.

Top Publications

  1. Yanes R, Tarn D, Hwang A, Ferris D, Sherman S, Thomas C, et al. Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition. Small. 2013;9:697-704 pubmed publisher
    The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event...
  2. Jung J, Shin Y, Konishi H, Lee S, Kiyama H. Possible ATP release through lysosomal exocytosis from primary sensory neurons. Biochem Biophys Res Commun. 2013;430:488-93 pubmed publisher
    ..In addition, the number of the quinacrine staining was decreased by application of lysosomal exocytosis activators, and this decrease was suppressed by the metformin and vacuolin-1, which suppressed lysosomal ..
  3. Cookson E, Conte I, Dempster J, Hannah M, Carter T. Characterisation of Weibel-Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis. J Cell Sci. 2013;126:5490-9 pubmed publisher
    Regulated secretion from endothelial cells is mediated by Weibel-Palade body (WPB) exocytosis. Plasma membrane cholesterol is implicated in regulating secretory granule exocytosis and fusion pore dynamics; however, its role in modulating ..
  4. Samie M, Wang X, Zhang X, Goschka A, Li X, Cheng X, et al. A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev Cell. 2013;26:511-24 pubmed publisher
    ..Here, we identified mucolipin TRP channel 1 (TRPML1) as the key lysosomal Ca2+ channel regulating focal exocytosis and phagosome biogenesis...
  5. Xie L, Zhu D, Kang Y, Liang T, He Y, Gaisano H. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PLoS ONE. 2013;8:e67561 pubmed publisher
    ..Here, we assessed ? cell exocytosis by patch clamp membrane capacitance measurement and total internal reflection fluorescence microscopy to ..
  6. Xu J, Chen Q, Zen K, Zhang C, Zhang Q. Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways. J Neurochem. 2013;124:15-25 pubmed publisher
    ..MiRNA secretion by the synaptosome was Ca(2+)-dependent and was inhibited by the exocytosis inhibitor, okadaic acid...
  7. Zhang Y, Tang W, Zhang H, Niu X, Xu Y, Zhang J, et al. A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils. Dev Cell. 2013;27:215-226 pubmed publisher
    ..STK24 appears to suppress exocytosis by interacting and competing with UNC13D C2B domain for lipid binding, whereas CCM3 has dual roles in exocytosis ..
  8. Agarwal S, Singh M, Garg S, Chitnis C, Singh S. Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoites. Cell Microbiol. 2013;15:910-21 pubmed publisher
    ..A complete understanding of the steps regulating egress of P.?falciparum merozoites may provide novel targets for development of drugs that block egress and limit parasite growth. ..
  9. Uriarte S, Rane M, Merchant M, Jin S, Lentsch A, Ward R, et al. Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats. Shock. 2013;39:286-92 pubmed publisher
    b>Exocytosis of neutrophil granules contributes to acute lung injury (ALI) induced by infection or inflammation, suggesting that inhibition of neutrophil exocytosis in vivo could be a viable therapeutic strategy...

More Information

Publications62

  1. Iyer J, Wahlmark C, Kuser Ahnert G, Kawasaki F. Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant. Mol Cell Neurosci. 2013;56:244-54 pubmed publisher
    ..These results indicate that spatially distinct and separable interactions of CPX with presynaptic membranes and SNARE proteins mediate separable activation and clamping functions of CPX in neurotransmitter release. ..
  2. Lee H, Cho E, Lee K, Kim J, Cho S, Lee S. Autophagic failure promotes the exocytosis and intercellular transfer of ?-synuclein. Exp Mol Med. 2013;45:e22 pubmed publisher
    ..results demonstrated that autophagic inhibition, via both pharmacological and genetic methods, led to increased exocytosis of ?-synuclein...
  3. McLeish K, Uriarte S, Tandon S, Creed T, Le J, Ward R. Exocytosis of neutrophil granule subsets and activation of prolyl isomerase 1 are required for respiratory burst priming. J Innate Immun. 2013;5:277-89 pubmed publisher
    This study tested the hypothesis that priming the neutrophil respiratory burst requires both granule exocytosis and activation of the prolyl isomerase Pin1...
  4. Alabi A, Tsien R. Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission. Annu Rev Physiol. 2013;75:393-422 pubmed publisher
    Regulated exocytosis and endocytosis are critical to the function of many intercellular networks, particularly the complex neural circuits underlying mammalian behavior...
  5. Morland C, Nordengen K, Larsson M, Prolo L, Farzampour Z, Reimer R, et al. Vesicular uptake and exocytosis of L-aspartate is independent of sialin. FASEB J. 2013;27:1264-74 pubmed publisher
    ..We further show that sialin is not essential for exocytosis of l-aspartate, as there was no difference in ATP-dependent l-aspartate uptake in synaptic vesicles from sialin-..
  6. Shin Y, Lee S, Jung J. Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degeneration. Biochem Biophys Res Commun. 2012;429:163-7 pubmed publisher
    The present study demonstrates that adenosine triphosphate (ATP) is released from Schwann cells through lysosomal exocytosis during Wallerian degeneration and in response to stimulation...
  7. Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, et al. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-? secretion via deregulated lysosomal exocytosis. Nat Commun. 2013;4:2734 pubmed publisher
    ..amyloid precursor protein in lysosomes, and extracellular release of A? peptides by excessive lysosomal exocytosis. Furthermore, cerebral injection of NEU1 in an established AD mouse model substantially reduces ?-amyloid ..
  8. Kim M, Li G, von Gersdorff H. Single Ca2+ channels and exocytosis at sensory synapses. J Physiol. 2013;591:3167-78 pubmed publisher
    ..of a hair cell synapse may be such that the opening of a single Ca(2+) channel evokes the simultaneous exocytosis of multiple synaptic vesicles...
  9. Yang X, Cao P, Sudhof T. Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A. 2013;110:20777-82 pubmed publisher
    ..protein that avidly binds to assembled SNARE complexes, is widely acknowledged to activate Ca(2+)-triggered exocytosis. In addition, studies of invertebrate complexin mutants and of mouse neurons with a double knockdown (DKD) of ..
  10. Sakaki H, Tsukimoto M, Harada H, Moriyama Y, Kojima S. Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLoS ONE. 2013;8:e59778 pubmed publisher
    ..We show here that ATP release via exocytosis, followed by activation of P2Y11 receptor, is a major pathway of the macrophage activation, leading to release ..
  11. Gregory F, Pangrsic T, Calin Jageman I, Moser T, Lee A. Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells. J Physiol. 2013;591:3253-69 pubmed publisher
    Cav1.3 channels mediate Ca(2+) influx that triggers exocytosis of glutamate at cochlear inner hair cell (IHC) synapses. Harmonin is a PDZ-domain-containing protein that interacts with the C-terminus of the Cav1.3 ?1 subunit (?11...
  12. Izquierdo Serra M, Trauner D, Llobet A, Gorostiza P. Optical control of calcium-regulated exocytosis. Biochim Biophys Acta. 2013;1830:2853-60 pubmed
    ..LiGluR in order to reversibly manipulate cytosolic calcium concentration, thus controlling calcium-regulated exocytosis. Bovine chromaffin cells expressing LiGluR were stimulated with light...
  13. Imura Y, Morizawa Y, Komatsu R, Shibata K, Shinozaki Y, Kasai H, et al. Microglia release ATP by exocytosis. Glia. 2013;61:1320-30 pubmed publisher
    ..Here we show that exocytosis is the mechanism by which microglia release ATP...
  14. Gumenyuk V, Chunikhin A, Himmelreich N, Trikash I. The phenomenon of synaptic vesicle clustering as the prefusion state in the model system of exocytosis. Gen Physiol Biophys. 2013;32:545-58 pubmed publisher
    ..that were reconstructed in the cell-free system and are thought to represent the different states of exocytosis pathway...
  15. Baudhuin J, Migraine J, Faivre V, Loumagne L, Lukaszewicz A, Payen D, et al. Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions. Proc Natl Acad Sci U S A. 2013;110:17957-62 pubmed publisher
    ..Altogether, our results reveal a unique mechanism of regulation of neutrophil functions through ILT4 and its exocytosis that may have implications in inflammatory disorders.
  16. Honigmann A, van den Bogaart G, Iraheta E, Risselada H, Milovanovic D, Mueller V, et al. Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol. 2013;20:679-86 pubmed publisher
    Synaptic-vesicle exocytosis is mediated by the vesicular Ca(2+) sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2)...
  17. Kawamata H, Ng S, Diaz N, Burstein S, Morel L, Osgood A, et al. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J Neurosci. 2014;34:2331-48 pubmed publisher
    ..Here we investigated abnormal calcium homeostasis and altered exocytosis in SOD1G93A astrocytes...
  18. Kasai H, Takahashi N, Tokumaru H. Distinct initial SNARE configurations underlying the diversity of exocytosis. Physiol Rev. 2012;92:1915-64 pubmed publisher
    The dynamics of exocytosis are diverse and have been optimized for the functions of synapses and a wide variety of cell types...
  19. Corbacho J, Romojaro F, Pech J, Latche A, Gomez Jimenez M. Transcriptomic events involved in melon mature-fruit abscission comprise the sequential induction of cell-wall degrading genes coupled to a stimulation of endo and exocytosis. PLoS ONE. 2013;8:e58363 pubmed publisher
    ..Here, we use pyrosequencing to characterize the transcriptomes of melon abscission zone (AZ) at three stages during AZ-cell separation in order to understand MFA control at an early stage of AZ-activation...
  20. Pinheiro P, de Wit H, Walter A, Groffen A, Verhage M, Sørensen J. Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release. J Neurosci. 2013;33:16459-70 pubmed publisher
    Synaptotagmin-1 and -7 constitute the main calcium sensors mediating SNARE-dependent exocytosis in mouse chromaffin cells, but the role of a closely related calcium-binding protein, Doc2b, remains enigmatic...
  21. Stehbens S, Paszek M, Pemble H, Ettinger A, Gierke S, Wittmann T. CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat Cell Biol. 2014;16:561-73 pubmed publisher
    ..We propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates FA turnover by severing cell-matrix connections...
  22. Xu M, Liu K, Swaroop M, Porter F, Sidhu R, Firnkes S, et al. ?-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem. 2012;287:39349-60 pubmed publisher
    ..may be mediated by a ?-tocopherol-induced intracellular Ca(2+) response and subsequent enhancement of lysosomal exocytosis. Consistent with a general mechanism for reduction of lysosomal lipid accumulation, we also found that ?-..
  23. Mellander L, Trouillon R, Svensson M, Ewing A. Amperometric post spike feet reveal most exocytosis is via extended kiss-and-run fusion. Sci Rep. 2012;2:907 pubmed publisher
    The basis for communication between nerve cells lies in the process of exocytosis, the fusion of neurotransmitter filled vesicles with the cell membrane resulting in release of the signaling molecules...
  24. Tomatis V, Papadopulos A, Malintan N, Martin S, Wallis T, Gormal R, et al. Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin. J Cell Biol. 2013;200:301-20 pubmed publisher
    ..Myosin VI knockdown selectively impaired a late phase of exocytosis, consistent with a replenishment defect...
  25. Kalwat M, Yoder S, Wang Z, Thurmond D. A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic ? cells. Biochem Pharmacol. 2013;85:808-16 pubmed publisher
  26. Chiang S, Theorell J, Entesarian M, Meeths M, Mastafa M, Al Herz W, et al. Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production. Blood. 2013;121:1345-56 pubmed publisher
    ..cytotoxic lymphocyte subsets have similar requirements for Munc13-4, syntaxin-11, and Munc18-2 in lytic granule exocytosis. The present results provide a detailed comparison of human CD3(+)CD8(+)CD57(bright) CTLs and NK cells and ..
  27. Lipovsek S, Janžekovič F, Leitinger G, Rupnik M. Rab3a ablation related changes in morphology of secretory vesicles in major endocrine pancreatic cells, pituitary melanotroph cells and adrenal gland chromaffin cells in mice. Gen Comp Endocrinol. 2013;185:67-79 pubmed publisher
    ..proteins in controlling the balance between secretory vesicle biogenesis and degradation, and suggest that the ablation of this protein probably changes the nature of the reservoir of secretory vesicles available for regulated exocytosis.
  28. Jorquera R, Huntwork Rodriguez S, Akbergenova Y, Cho R, Littleton J. Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci. 2012;32:18234-45 pubmed publisher
    ..Synaptic exocytosis is a specialized form of intercellular communication that shares a common SNARE-mediated fusion mechanism with ..
  29. Zhang Z, Takeuchi H, Gao J, Wang D, James D, Martin T, et al. PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain. J Biol Chem. 2013;288:7769-80 pubmed publisher
    Membrane fusion for exocytosis is mediated by SNAREs, forming trans-ternary complexes to bridge vesicle and target membranes. There is an array of accessory proteins that directly interact with and regulate SNARE proteins...
  30. McCusker D, Kellogg D. Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress. Curr Opin Cell Biol. 2012;24:845-51 pubmed publisher
    ..Further analysis of these links will yield insights into conserved and fundamental mechanisms of cell growth. A better understanding of the post-Golgi pathways by which membrane growth occurs will be essential for future progress. ..
  31. Wall M, Dale N. Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus. J Physiol. 2013;591:3853-71 pubmed publisher
    ..These data suggest that activity-dependent adenosine release is surprisingly complex and, in the hippocampus, arises from at least two distinct mechanisms with different cellular sources. ..
  32. Cabeza J, Acosta J, Ales E. Mechanisms of granule membrane recapture following exocytosis in intact mast cells. J Biol Chem. 2013;288:20293-305 pubmed publisher
    In secretory cells, several exocytosis-coupled forms of endocytosis have been proposed including clathrin-mediated endocytosis, kiss-and-run endocytosis, cavicapture, and bulk endocytosis...
  33. Cao P, Yang X, Sudhof T. Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J Neurosci. 2013;33:1714-27 pubmed publisher
    Complexins are SNARE-complex binding proteins essential for the Ca(2+)-triggered exocytosis mediated by synaptotagmin-1, -2, -7, or -9, but the possible role of complexins in other types of exocytosis controlled by other synaptotagmin ..
  34. Bittner M, Aikman R, Holz R. A nibbling mechanism for clathrin-mediated retrieval of secretory granule membrane after exocytosis. J Biol Chem. 2013;288:9177-88 pubmed publisher
    ..We demonstrate that the fused granule membrane remains a distinct entity and serves as a nucleation site for clathrin- and dynamin-mediated endocytosis that internalizes granule membrane components in small increments. ..
  35. Dhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam P, et al. Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol. 2014;204:1123-40 pubmed publisher
    ..ComplexinII (CpxII) and SynaptotagminI (SytI) have been implicated in regulating the function of SNARE proteins in exocytosis, but their precise mode of action and potential interplay have remained unknown...
  36. Watanabe S, Rost B, Camacho Perez M, Davis M, Söhl Kielczynski B, Rosenmund C, et al. Ultrafast endocytosis at mouse hippocampal synapses. Nature. 2013;504:242-247 pubmed publisher
    ..It is likely that 'ultrafast endocytosis' is specialized to restore the surface area of the membrane rapidly. ..
  37. Wong A, Rutherford M, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, et al. Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis. EMBO J. 2014;33:247-64 pubmed publisher
    ..3-channels were selectively reduced, (iv) the intrinsic Ca(2)(+) dependence of fast exocytosis probed by Ca(2)(+) uncaging remained unchanged but (v) the apparent Ca(2)(+) dependence of exocytosis linearized,..
  38. Poea Guyon S, Ammar M, Erard M, Amar M, Moreau A, Fossier P, et al. The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery. J Cell Biol. 2013;203:283-98 pubmed publisher
    ..domain of the vacuolar-type H(+)-adenosine triphosphatase (V-ATPase) is directly implicated in secretory vesicle exocytosis through a role in membrane fusion...
  39. Yu H, Rathore S, Davis E, Ouyang Y, Shen J. Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner. Mol Biol Cell. 2013;24:1176-84 pubmed publisher
    ..These results demonstrate that Doc2b promotes GLUT4 exocytosis by accelerating the SNARE-dependent fusion reaction by a Ca(2+)- and membrane bending-dependent mechanism...
  40. Polishchuk E, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, et al. Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis. Dev Cell. 2014;29:686-700 pubmed publisher
    ..ATP7B enables lysosomes to undergo exocytosis through the interaction with p62 subunit of dynactin that allows lysosome translocation toward the canalicular ..
  41. Lam P, Ohno M, Dolai S, He Y, Qin T, Liang T, et al. Munc18b is a major mediator of insulin exocytosis in rat pancreatic ?-cells. Diabetes. 2013;62:2416-28 pubmed publisher
    ..Two-photon imaging analysis revealed in Munc18b-depleted ?-cells a 40% reduction in primary exocytosis (SG-PM fusion) and abrogation of almost all sequential SG-SG fusion, together accounting for a 50% reduction in ..
  42. Koseoglu S, Dilks J, Peters C, Fitch Tewfik J, Fadel N, Jasuja R, et al. Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis. Arterioscler Thromb Vasc Biol. 2013;33:481-8 pubmed publisher
    Platelet granule exocytosis serves a central role in hemostasis and thrombosis...
  43. Davis L, Morgan A, Chen J, Snead C, Bloor Young D, Shenderov E, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012;22:2331-7 pubmed publisher
    A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca(2+)-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells...
  44. Jahn R, Fasshauer D. Molecular machines governing exocytosis of synaptic vesicles. Nature. 2012;490:201-7 pubmed publisher
    Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13...
  45. Xu J, Toops K, Diaz F, Carvajal Gonzalez J, Gravotta D, Mazzoni F, et al. Mechanism of polarized lysosome exocytosis in epithelial cells. J Cell Sci. 2012;125:5937-43 pubmed publisher
    ..In non-polarized cells, lysosome exocytosis facilitates rapid resealing of torn membranes...
  46. Okada S, Leda M, Hanna J, Savage N, Bi E, Goryachev A. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Dev Cell. 2013;26:148-61 pubmed publisher
    ..live-cell imaging and computational modeling, we demonstrate that the septin ring is sculpted by polarized exocytosis, which creates a hole in the accumulating septin density and relieves the inhibition of Cdc42...
  47. Monti M, Donnini S, Morbidelli L, Giachetti A, Mochly Rosen D, Mignatti P, et al. PKC? activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting. J Mol Cell Cardiol. 2013;63:107-17 pubmed publisher
    ..fails to elicit responses in FGF-2(-/-) endothelial cells, and in cells pretreated with methylamine (MeNH2), an exocytosis inhibitor, indicating that both intracellular FGF-2 and its export toward the membrane are required for the ??..
  48. Wang D, Hiesinger P. The vesicular ATPase: a missing link between acidification and exocytosis. J Cell Biol. 2013;203:171-3 pubmed publisher
    ..A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process...
  49. Lin M, Rohan J, Cai H, Reim K, Ko C, Chow R. Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol. 2013;591:2463-73 pubmed publisher
    Complexins (Cplxs) are small, SNARE-associated proteins believed to regulate fast, calcium-triggered exocytosis. However, studies have pointed to either an inhibitory and/or facilitatory role in exocytosis, and the role of Cplxs in ..
  50. Khandelwal P, Prakasam H, Clayton D, Ruiz W, Gallo L, van Roekel D, et al. A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Mol Biol Cell. 2013;24:1007-19 pubmed publisher
    ..Rabs are associated with secretory granules/vesicles, but how these GTPases are coordinated to promote regulated exocytosis is not well understood...
  51. Xie L, Kang Y, Liang T, Dolai S, Xie H, Parsaud L, et al. RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding ?2 ?-1 subunit. Traffic. 2013;14:428-39 pubmed publisher
    ..This acts as a chaperoning step prior to and in preparation for sequential assembly of exocyst and excitosome complexes that mediate biphasic insulin secretion...
  52. Torregrosa Hetland C, Villanueva J, Garcia Mart nez V, Exp sito Romero G, Guti rrez L. Cortical F-actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells. Int J Biochem Cell Biol. 2013;45:583-92 pubmed publisher
    ..idea, we used confocal microscopy do determine if DsRed-SNAP-25 microdomains, which define the final sites of exocytosis along with syntaxin-1, preferentially remain in contact with F-actin cortical structures labelled by lifeact-..
  53. Xu J, Luo F, Zhang Z, Xue L, Wu X, Chiang H, et al. SNARE proteins synaptobrevin, SNAP-25, and syntaxin are involved in rapid and slow endocytosis at synapses. Cell Rep. 2013;3:1414-21 pubmed publisher
    ..Here, we report that cleavage of three SNARE proteins essential for exocytosis, including synaptobrevin, SNAP-25, and syntaxin, inhibited rapid endocytosis at the calyx of Held nerve terminal,..