Summary: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.

Top Publications

  1. Duncker S, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, et al. Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J Neurosci. 2013;33:9508-19 pubmed publisher
    ..multiple subunits of the adaptor protein complex AP-2 (CLAP), an essential component of clathrin-mediated endocytosis, as binding partners of otoferlin in rats and mice...
  2. Seki T, Gong L, WILLIAMS A, Sakai N, Todi S, Paulson H. JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. J Biol Chem. 2013;288:17145-55 pubmed publisher
    ..occupancy by JosD1 suggests that it could participate in membrane-dependent events such as cell motility and endocytosis. Indeed, time-lapse imaging revealed that JosD1 enhances membrane dynamics and cell motility...
  3. Sahlender D, Kozik P, Miller S, Peden A, Robinson M. Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation. PLoS ONE. 2013;8:e64514 pubmed publisher
    ..Using a flow cytometry-based endocytosis efficiency assay, we demonstrate that CALM is also able to sort VAMPs 4 and 7, even though they have sorting ..
  4. Zhang Z, Wang D, Sun T, Xu J, Chiang H, Shin W, et al. The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses. J Neurosci. 2013;33:9169-75 pubmed publisher
    ..attachment protein receptor (SNARE) complex that mediates exocytosis, is not considered to play a role in endocytosis, which couples to exocytosis by retrieving a similar amount of exocytosed vesicles...
  5. Das U, Scott D, Ganguly A, Koo E, Tang Y, Roy S. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013;79:447-60 pubmed publisher
  6. Xu J, Luo F, Zhang Z, Xue L, Wu X, Chiang H, et al. SNARE proteins synaptobrevin, SNAP-25, and syntaxin are involved in rapid and slow endocytosis at synapses. Cell Rep. 2013;3:1414-21 pubmed publisher
    Rapid endocytosis, which takes only a few seconds, is widely observed in secretory cells...
  7. Grassart A, Cheng A, Hong S, Zhang F, Zenzer N, Feng Y, et al. Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis. J Cell Biol. 2014;205:721-35 pubmed publisher
    Clathrin-mediated endocytosis (CME) involves the recruitment of numerous proteins to sites on the plasma membrane with prescribed timing to mediate specific stages of the process...
  8. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39 pubmed publisher
    ..The endocytosis of HMGB1 triggers a cascade of molecular events, including cathepsin B release from ruptured lysosomes followed ..
  9. Kong X, Tang X, Du W, Tong J, Yan Y, Zheng F, et al. Extracellular acidosis modulates the endocytosis and maturation of macrophages. Cell Immunol. 2013;281:44-50 pubmed publisher
    ..The results showed that extracellular acidosis upregulated the endocytosis, surface molecular expression and interleukin-10 secretion of BMMs, in which the expression of ASIC1 and ASIC3 ..

More Information


  1. Clement C, Ajbro K, Koefoed K, Vestergaard M, Veland I, Henriques de Jesus M, et al. TGF-? signaling is associated with endocytosis at the pocket region of the primary cilium. Cell Rep. 2013;3:1806-14 pubmed publisher
    Transforming growth factor ? (TGF-?) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis...
  2. Vehlow A, Soong D, Vizcay Barrena G, Bodo C, Law A, Perera U, et al. Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis. EMBO J. 2013;32:2722-34 pubmed publisher
    ..However, it is unknown whether this mechanism supports endocytosis of the EGFR...
  3. Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H. Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells. J Virol. 2013;87:10334-47 pubmed publisher
    ..our data indicate that exosomes released from EBV-infected B cells are internalized via caveola-dependent endocytosis, which, in turn, contributes to phenotypic changes in the recipient cells through transferring one or more ..
  4. Serra Moreno R, Zimmermann K, Stern L, Evans D. Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog. 2013;9:e1003487 pubmed publisher
    ..for tetherin antagonism, and show that the anti-tetherin activity of Nef is dependent on clathrin-mediated endocytosis. SIV Nef co-immunoprecipitated with rhesus macaque tetherin and the Nef core domain bound directly to a peptide ..
  5. Li H, Alavian K, Lazrove E, Mehta N, Jones A, Zhang P, et al. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat Cell Biol. 2013;15:773-85 pubmed publisher
    ..Mutagenesis studies suggest that formation of the Bcl-xL-Drp1 complex is necessary for the enhanced rate of vesicle endocytosis produced by Bcl-xL, thus providing a mechanism for presynaptic plasticity.
  6. Sun C, Velazquez M, Marfy Smith S, Sheth B, Cox A, Johnston D, et al. Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition. Development. 2014;141:1140-50 pubmed publisher
    ..early mechanisms of compensatory nutrient provision, we assessed the influence of maternal Emb-LPD on endocytosis within extra-embryonic lineages using quantitative imaging and expression of markers and proteins involved...
  7. Lee M, Skoura A, Park E, Landskroner Eiger S, Jozsef L, Luciano A, et al. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development. 2014;141:1465-72 pubmed publisher
    ..Collectively, our data show that Dnm2 uncouples VEGF signaling from function and coordinates the endocytic turnover of integrins in a manner that is crucially important for angiogenesis in vitro and in vivo. ..
  8. Johnson K, Mitra S, Katoch P, Kelsey L, Johnson K, Mehta P. Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells. Mol Biol Cell. 2013;24:715-33 pubmed publisher
    ..Connexin43 fails to assemble, because it is internalized by clathrin-mediated endocytosis. Assembly is restored upon expressing a sorting-motif mutant of Cx43, which does not interact with the AP2 ..
  9. Lépinoux Chambaud C, Eyer J. The NFL-TBS.40-63 anti-glioblastoma peptide enters selectively in glioma cells by endocytosis. Int J Pharm. 2013;454:738-47 pubmed publisher
    ..40-63 peptide by glioblastoma cells. Unlike other cell penetrating peptides (CPPs), which use a balance between endocytosis and direct translocation, the NFL-TBS...
  10. Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler H, et al. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol. 2013;15:249-60 pubmed publisher
    ..Here, we show that sprouting endothelial cells in the retina have high rates of VEGF uptake, VEGF receptor endocytosis and turnover...
  11. Scotti E, Calamai M, Goulbourne C, Zhang L, Hong C, Lin R, et al. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013;33:1503-14 pubmed publisher
    ..a critical determinant of plasma cholesterol levels that internalizes lipoprotein cargo via clathrin-mediated endocytosis. Here, we show that the E3 ubiquitin ligase IDOL stimulates a previously unrecognized, clathrin-independent ..
  12. Park R, Shen H, Liu L, Liu X, Ferguson S, De Camilli P. Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors. J Cell Sci. 2013;126:5305-12 pubmed publisher
    ..These DKO cells were unexpectedly viable in spite of a severe impairment of clathrin-mediated endocytosis. As low-level expression of the dynamin 3 gene in these cells could not be excluded, we have now engineered ..
  13. Tenay B, Kimberlin E, Williams M, Denise J, Fakilahyel J, Kim K. Inactivation of Tor proteins affects the dynamics of endocytic proteins in early stage of endocytosis. J Biosci. 2013;38:351-61 pubmed
    ..Taken together, both functional Tor proteins, Tor1 and Tor2, are essentially required for proper endocytic protein dynamics at the early stage of endocytosis.
  14. Kumano Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S. Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Biochem Biophys Res Commun. 2013;434:594-9 pubmed publisher
    ..Here, we found that LOX-1 recognized and internalized ligands through the caveolae/raft-dependent endocytosis pathway in human coronary artery endothelial cells...
  15. Pellon Cardenas O, Clancy J, Uwimpuhwe H, D SOUZA SCHOREY C. ARF6-regulated endocytosis of growth factor receptors links cadherin-based adhesion to canonical Wnt signaling in epithelia. Mol Cell Biol. 2013;33:2963-75 pubmed publisher
    ..canonical Wnt signaling promotes the intracellular accumulation of ?-catenin via a mechanism that involves the endocytosis of growth factor receptors and robust activation of extracellular signal-regulated kinase (ERK)...
  16. Watanabe S, Rost B, Camacho Perez M, Davis M, Söhl Kielczynski B, Rosenmund C, et al. Ultrafast endocytosis at mouse hippocampal synapses. Nature. 2013;504:242-247 pubmed publisher
    ..the assembly of clathrin scaffolds or in approximately 1?s by the reversal of fusion pores via 'kiss-and-run' endocytosis. Here we use optogenetics to stimulate cultured hippocampal neurons with a single stimulus, rapidly freeze them ..
  17. Gehr P, Clift M, Brandenberger C, Lehmann A, Herzog F, Rothen Rutishauser B. Endocytosis of environmental and engineered micro- and nanosized particles. Compr Physiol. 2011;1:1159-74 pubmed publisher
    ..However, with NPs it is different. NPs may not be eliminated easily, and, hence may stimulate the cells to react in an unfavorable way. What we can learn is that NPs behave differently than microparticles. ..
  18. Taoufiq Z, Eguchi K, Takahashi T. Rho-kinase accelerates synaptic vesicle endocytosis by linking cyclic GMP-dependent protein kinase activity to phosphatidylinositol-4,5-bisphosphate synthesis. J Neurosci. 2013;33:12099-104 pubmed publisher
    ..Vesicles consumed by excessive exocytosis are replenished by accelerating vesicle endocytosis via a retrograde feedback mechanism involving nitric oxide released from postsynaptic cells...
  19. Lin H, Yang Y, Yu S, Hsiao K, Liu C, Sia C, et al. Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection. J Virol. 2013;87:9064-76 pubmed publisher
    ..The underling mechanism of PSGL-1-mediated EV71 entry remains unclear. The endocytosis required for EV71 entry were investigated in Jurkat T and mouse L929 cells constitutively expressing human PSGL-..
  20. Sorkina T, Caltagarone J, Sorkin A. Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis. Traffic. 2013;14:709-24 pubmed publisher
    Flotillins were proposed to mediate clathrin-independent endocytosis, and recently, flotillin-1 was implicated in the protein kinase C (PKC)-triggered endocytosis of the dopamine transporter (DAT)...
  21. McCluskey A, Daniel J, Hadzic G, Chau N, Clayton E, Mariana A, et al. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic. 2013;14:1272-89 pubmed publisher
    ..4a and 6a inhibited dynamin-dependent endocytosis of transferrin in multiple cell types (IC?? of 5.7 and 5...
  22. Kim S, Xu Z, Song K, Kim D, Kang H, Reichardt I, et al. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in Arabidopsis. Plant Cell. 2013;25:2970-85 pubmed publisher
    ..Here, we present evidence that endocytosis, involving heterotetrameric adaptor protein complex 2 (AP-2), plays a crucial role in fertilization...
  23. Yang S, He M, Liu X, Li X, Fan B, Zhao S. Japanese encephalitis virus infects porcine kidney epithelial PK15 cells via clathrin- and cholesterol-dependent endocytosis. Virol J. 2013;10:258 pubmed publisher
    ..reduced JEV-infected cells and JEV E-glycoprotein levels, suggesting that JEV utilizes clathrin-dependent endocytosis. In contrast, the knockdown of caveolin-1, a principal component of caveolae, had only a small (although ..
  24. Hua Y, Woehler A, Kahms M, Haucke V, Neher E, Klingauf J. Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles. Neuron. 2013;80:343-9 pubmed publisher
    It is commonly thought that clathrin-mediated endocytosis is the rate-limiting step of synaptic transmission in small CNS boutons with limited capacity for synaptic vesicles, causing short-term depression during high rates of synaptic ..
  25. Xie M, Zhang H, Xu Y, Liu T, Chen S, Wang J, et al. Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine. Int J Nanomedicine. 2013;8:2443-51 pubmed publisher
    ..Iron staining, electron microscopy, and magnetic resonance imaging were used to observe endocytosis of folate-conjugated cisplatin-loaded magnetic nanoparticles (CDDP-FA-ASA-MNP) in cultured cells and ..
  26. Rampazzo E, Voltan R, Petrizza L, Zaccheroni N, Prodi L, Casciano F, et al. Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis. Nanoscale. 2013;5:7897-905 pubmed publisher
    ..Finally, experiments performed with the endocytosis inhibitor Genistein clearly suggested the involvement of a caveolae-mediated pathway in SiNP endocytosis...
  27. Gadeyne A, S nchez Rodr guez C, Vanneste S, Di Rubbo S, Zauber H, Vanneste K, et al. The TPLATE adaptor complex drives clathrin-mediated endocytosis in plants. Cell. 2014;156:691-704 pubmed publisher
    Clathrin-mediated endocytosis is the major mechanism for eukaryotic plasma membrane-based proteome turn-over...
  28. Morgan J, Jiang J, Oliphint P, Jin S, Gimenez L, Busch D, et al. A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis. J Neurosci. 2013;33:8009-21 pubmed publisher
    ..SV membranes and membrane proteins are retrieved from the presynaptic plasma membrane by clathrin-mediated endocytosis. After the internalization of a clathrin-coated vesicle, the vesicle must uncoat to replenish the pool of SVs...
  29. Copits B, Swanson G. Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis. J Biol Chem. 2013;288:8952-65 pubmed publisher
    ..trafficking of GluK2a receptors, their distribution in the neuronal plasma membrane, and regulation of receptor endocytosis. The association between GluK2a receptors and 4...
  30. Congdon E, Gu J, Sait H, Sigurdsson E. Antibody uptake into neurons occurs primarily via clathrin-dependent Fc? receptor endocytosis and is a prerequisite for acute tau protein clearance. J Biol Chem. 2013;288:35452-65 pubmed publisher
    ..0001) and slices (? 35%, p = 0.03), demonstrating receptor-mediated endocytosis as the primary uptake pathway...
  31. Boissier P, Chen J, Huynh Do U. EphA2 signaling following endocytosis: role of Tiam1. Traffic. 2013;14:1255-71 pubmed publisher
    ..Recently, Eph endocytosis has been identified as one of the critical steps responsible for such diversity...
  32. Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente A, Pelucchi S, et al. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest. 2013;123:2523-38 pubmed publisher
    ..homogenates, we found that ADAM10 removal from the plasma membrane was mediated by clathrin-dependent endocytosis. Additionally, we identified the clathrin adaptor AP2 as an interacting partner of a previously uncharacterized ..
  33. Sigismund S, Algisi V, Nappo G, Conte A, Pascolutti R, Cuomo A, et al. Threshold-controlled ubiquitination of the EGFR directs receptor fate. EMBO J. 2013;32:2140-57 pubmed publisher
    ..The dose-response curve of EGFR ubiquitination correlate precisely with the non-clathrin endocytosis (NCE) mode of EGFR internalization...
  34. Spiess M, De Craene J, Michelot A, Rinaldi B, Huber A, Drubin D, et al. Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis. PLoS ONE. 2013;8:e61147 pubmed publisher
    ..But, only Lsb1 overexpression blocks the internalization step of receptor-mediated endocytosis. This shows a specific function of Lsb1 in endocytosis.
  35. Godlee C, Kaksonen M. Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis. J Cell Biol. 2013;203:717-25 pubmed publisher
    Clathrin-mediated endocytosis is a central and well-studied trafficking process in eukaryotic cells...
  36. Matlack K, Tardiff D, Narayan P, Hamamichi S, Caldwell K, Caldwell G, et al. Clioquinol promotes the degradation of metal-dependent amyloid-? (A?) oligomers to restore endocytosis and ameliorate A? toxicity. Proc Natl Acad Sci U S A. 2014;111:4013-8 pubmed publisher
    ..Establishing the ability of the A? yeast model to identify disease-relevant compounds supports its further exploitation as a validated early discovery platform. ..
  37. Gorvin C, Wilmer M, Piret S, Harding B, van den Heuvel L, Wrong O, et al. Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients. Proc Natl Acad Sci U S A. 2013;110:7014-9 pubmed publisher
    Receptor-mediated endocytosis, involving megalin and cubilin, mediates renal proximal-tubular reabsorption and is decreased in Dent disease because of mutations of the chloride/proton antiporter, chloride channel-5 (CLC-5), resulting in ..
  38. Sadowski Ł, Jastrzębski K, Kalaidzidis Y, Heldin C, Hellberg C, Miaczynska M. Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF. Traffic. 2013;14:725-36 pubmed publisher
    ..At the cellular level, growth-factor signaling is often modulated by endocytosis. Despite important functions of PDGF, its endocytosis remains poorly studied, mainly for lack of tools to track ..
  39. Liu B, Huang Y, Lee H. Mechanistic studies of intracellular delivery of proteins by cell-penetrating peptides in cyanobacteria. BMC Microbiol. 2013;13:57 pubmed publisher
    ..The ATP-depleting inhibitor of classical endocytosis, N-ethylmaleimide (NEM), could block the spontaneous internalization of GFP, but not the transduction of R9/GFP ..
  40. Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, et al. Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response. Toxicol In Vitro. 2013;27:1679-85 pubmed publisher
    ..Moreover, we evaluated whether MWCNT uptake was suppressed by 2 types of endocytosis inhibitors...
  41. Piccinotti S, Kirchhausen T, Whelan S. Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin. J Virol. 2013;87:11637-47 pubmed publisher
    ..This work extends to RABV particles the finding that clathrin-mediated endocytosis of rhabdoviruses proceeds through incompletely coated pits which depend upon actin.
  42. Pereira C, Miguel Martins L, Saraiva L. LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model. Biochim Biophys Acta. 2014;1840:2025-31 pubmed publisher
    ..The involvement of endocytosis was also studied by testing several endocytic mutants and by following the vacuolar delivery of the probe FM4-..
  43. Yue H, Xu J. Myosin light chain kinase accelerates vesicle endocytosis at the calyx of Held synapse. J Neurosci. 2014;34:295-304 pubmed publisher
    Neuronal activity triggers endocytosis at synaptic terminals to retrieve efficiently the exocytosed vesicle membrane, ensuring the membrane homeostasis of active zones and the continuous supply of releasable vesicles...
  44. Chowdhury D, Marco S, Brooks I, Zandueta A, Rao Y, Haucke V, et al. Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors. J Neurosci. 2013;33:4151-64 pubmed publisher
  45. Krishnan M, Kannan T, Baseman J. Mycoplasma pneumoniae CARDS toxin is internalized via clathrin-mediated endocytosis. PLoS ONE. 2013;8:e62706 pubmed publisher
    ..Furthermore, the internalization of CARDS toxin was markedly inhibited in clathrin-depleted cells. ..
  46. Dunn H, Walther C, Godin C, Hall R, Ferguson S. Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. J Biol Chem. 2013;288:15023-34 pubmed publisher
    ..hairpin (shRNA) knockdown of endogenous SAP97 in HEK 293 cells resulted in increased agonist-stimulated CRFR1 endocytosis. CRFR1 was internalized as a complex with SAP97 resulting in the redistribution of SAP97 to endocytic vesicles...
  47. Aguet F, Antonescu C, Mettlen M, Schmid S, Danuser G. Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell. 2013;26:279-91 pubmed publisher
    ..due to potential redundancy among EAPs and, as we show here, the plasticity and resilience of clathrin-mediated endocytosis (CME)...
  48. Irannejad R, Tomshine J, Tomshine J, Chevalier M, Mahoney J, Steyaert J, et al. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013;495:534-8 pubmed publisher
    ..These findings provide direct support for the hypothesis that canonical GPCR signalling occurs from endosomes as well as the plasma membrane, and suggest a versatile strategy for probing dynamic conformational change in vivo...
  49. Freeman D, Cedillos R, Choyke S, Lukic Z, MCGUIRE K, Marvin S, et al. Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis. PLoS ONE. 2013;8:e62143 pubmed publisher
    ..this approach, we demonstrate that ?-synuclein aggregates can induce the rupture of lysosomes following their endocytosis in neuronal cell lines...
  50. Matsuo K, Higuchi Y, Kikuma T, Arioka M, Kitamoto K. Functional analysis of Abp1p-interacting proteins involved in endocytosis of the MCC component in Aspergillus oryzae. Fungal Genet Biol. 2013;56:125-34 pubmed publisher
    We have investigated the functions of three endocytosis-related proteins in the filamentous fungus Aspergillus oryzae. Yeast two-hybrid screening using the endocytic marker protein AoAbp1 (A...
  51. Chandrasekar I, Huettner J, Turney S, Bridgman P. Myosin II regulates activity dependent compensatory endocytosis at central synapses. J Neurosci. 2013;33:16131-45 pubmed publisher
    Recent evidence suggests that endocytosis, not exocytosis, can be rate limiting for neurotransmitter release at excitatory CNS synapses during sustained activity and therefore may be a principal determinant of synaptic fatigue...
  52. Tumbarello D, Kendrick Jones J, Buss F. Myosin VI and its cargo adaptors - linking endocytosis and autophagy. J Cell Sci. 2013;126:2561-70 pubmed publisher
    ..The unique actin motor myosin VI functions at distinct steps during clathrin-mediated endocytosis and the early endocytic pathway - both of which are involved in cargo trafficking and sorting - through ..
  53. Fabrowski P, Necakov A, Mumbauer S, Loeser E, Reversi A, Streichan S, et al. Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila. Nat Commun. 2013;4:2244 pubmed publisher
    ..We show that the retraction of villous protrusions and subsequent apical plasma membrane flattening is an endocytosis-driven morphogenetic process...
  54. Posor Y, Eichhorn Gruenig M, Puchkov D, Schöneberg J, Ullrich A, Lampe A, et al. Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature. 2013;499:233-7 pubmed publisher
    ..No phosphatidylinositol other than PI(4,5)P2 has been implicated in clathrin-mediated endocytosis, whereas the subsequent endosomal stages of the endocytic pathway are dominated by phosphatidylinositol-3-..
  55. Gaengel K, Betsholtz C. Endocytosis regulates VEGF signalling during angiogenesis. Nat Cell Biol. 2013;15:233-5 pubmed publisher
    b>Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction...
  56. Mellman I, Yarden Y. Endocytosis and cancer. Cold Spring Harb Perspect Biol. 2013;5:a016949 pubmed publisher
    b>Endocytosis entails selective packaging of cell-surface proteins, such as receptors for cytokines and adhesion components, in cytoplasmic vesicles (endosomes)...
  57. Choi C, Hao L, Narayan S, Auyeung E, Mirkin C. Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proc Natl Acad Sci U S A. 2013;110:7625-30 pubmed publisher
    ..Unfortunately, little is known about the mechanism of endocytosis of SNAs, including the pathway of entry and specific proteins involved...
  58. Tuo S, Nakashima K, Pringle J. Role of endocytosis in localization and maintenance of the spatial markers for bud-site selection in yeast. PLoS ONE. 2013;8:e72123 pubmed publisher
    ..and analyzed congenic haploid and diploid deletion mutants for 14 genes encoding proteins that are involved in endocytosis. The mutants displayed a wide range of severities in their overall endocytosis defects, as judged by their ..
  59. Traub L, Bonifacino J. Cargo recognition in clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol. 2013;5:a016790 pubmed publisher
    ..Related sorting events occur at other endosomal sorting stations. ..
  60. Ritter B, Murphy S, Dokainish H, Girard M, Gudheti M, Kozlov G, et al. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. PLoS Biol. 2013;11:e1001670 pubmed publisher
    AP-2 is the core-organizing element in clathrin-mediated endocytosis. During the formation of clathrin-coated vesicles, clathrin and endocytic accessory proteins interact with AP-2 in a temporally and spatially controlled manner, yet it ..
  61. Yao L, Rao Y, Bang C, Kurilova S, Varga K, Wang C, et al. Actin polymerization does not provide direct mechanical forces for vesicle fission during clathrin-mediated endocytosis. J Neurosci. 2013;33:15793-8 pubmed publisher
    Actin polymerization is important for vesicle fission during clathrin-mediated endocytosis (CME), and it has been proposed that actin polymerization may promote vesicle fission during CME by providing direct mechanical forces...
  62. Röhrl C, Stangl H. HDL endocytosis and resecretion. Biochim Biophys Acta. 2013;1831:1626-33 pubmed publisher
    ..In addition, endocytosis of HDL holo-particles has been debated for nearly 40years...
  63. Dutta D, Chakraborty S, Bandyopadhyay C, Valiya Veettil M, Ansari M, Singh V, et al. EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination. PLoS Pathog. 2013;9:e1003510 pubmed publisher
    ..In contrast, KSHV enters human foreskin fibroblast (HFF) cells by LR-independent clathrin mediated endocytosis. The present studies conducted to identify the key molecules regulating KSHV entry in HFF cells showed that ..
  64. Shi W, Chen Y, Gan G, Wang D, Ren J, Wang Q, et al. Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression. J Neurosci. 2013;33:12352-63 pubmed publisher
    ..loss of Brat resulted in reduced FM1-43 uptake at the NMJ terminals, indicating that brat regulates synaptic endocytosis. Genetic analysis revealed that the actions of Brat at synapses are mediated through mothers against ..
  65. Lee D, Harris T. An Arf-GEF regulates antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development. Curr Biol. 2013;23:2110-20 pubmed publisher
    Actin cytoskeletal networks push and pull the plasma membrane (PM) to control cell structure and behavior. Endocytosis also regulates the PM and can be promoted or inhibited by cytoskeletal networks...
  66. Fan L, Hao H, Xue Y, Zhang L, Song K, Ding Z, et al. Dynamic analysis of Arabidopsis AP2 ? subunit reveals a key role in clathrin-mediated endocytosis and plant development. Development. 2013;140:3826-37 pubmed publisher
    Clathrin-mediated endocytosis, which depends on the AP2 complex, plays an essential role in many cellular and developmental processes in mammalian cells. However, the function of the AP2 complex in plants remains largely unexplored...