tumor microenvironment


Summary: The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.

Top Publications

  1. Stankevicius V, Kunigenas L, Stankunas E, Kuodyte K, Strainiene E, Cicenas J, et al. The expression of cancer stem cell markers in human colorectal carcinoma cells in a microenvironment dependent manner. Biochem Biophys Res Commun. 2017;484:726-733 pubmed publisher
    ..Therefore, in order to design more efficient targeted therapies, we suggest that 3D cell culture models should be employed in cancer stem cell research. ..
  2. Bottai G, Truffi M, Corsi F, Santarpia L. Progress in nonviral gene therapy for breast cancer and what comes next?. Expert Opin Biol Ther. 2017;17:595-611 pubmed publisher
    ..However, several challenges need to be addressed before considering gene therapy as an actual option for the treatment of breast cancer. ..
  3. Wang J, Mouradov D, Wang X, Jorissen R, Chambers M, Zimmerman L, et al. Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity. Gastroenterology. 2017;153:1082-1095 pubmed publisher
    ..Our integrative proteogenomic analysis highlights the potential of proteome profiling to inform personalized cancer medicine. ..
  4. Gu Y, Albuquerque C, Braas D, Zhang W, Villa G, Bi J, et al. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017;67:128-138.e7 pubmed publisher
    ..These results identify an unanticipated mechanism regulating amino acid metabolism in cancer, enabling tumor cells to adapt to changing environmental conditions. ..
  5. Nebot Bral L, Brandao D, Verlingue L, Rouleau E, Caron O, Despras E, et al. Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine. Eur J Cancer. 2017;84:290-303 pubmed publisher
    ..This breakthrough represents a turning point in the management of these hypermutated tumours and paves the way for broader strategies in immunoprecision medicine. ..
  6. Marvel D, Gabrilovich D. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J Clin Invest. 2015;125:3356-64 pubmed publisher
  7. Melief S, Visser M, van der Burg S, Verdegaal E. IDO and galectin-3 hamper the ex vivo generation of clinical grade tumor-specific T cells for adoptive cell therapy in metastatic melanoma. Cancer Immunol Immunother. 2017;66:913-926 pubmed publisher
    ..Implementation of these findings in clinical protocols for ex vivo expansion of tumor-reactive T cells holds promise for an increased therapeutic potential of adoptive cell transfer treatments with tumor-specific T cells. ..
  8. Munn D, Sharma M, Johnson T, Rodriguez P. IDO, PTEN-expressing Tregs and control of antigen-presentation in the murine tumor microenvironment. Cancer Immunol Immunother. 2017;66:1049-1058 pubmed publisher
    The tumor microenvironment is profoundly immunosuppressive...
  9. Zhou G, Sprengers D, Boor P, Doukas M, Schutz H, Mancham S, et al. Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas. Gastroenterology. 2017;153:1107-1119.e10 pubmed publisher
    ..Strategies to block PD-L1, TIM3, and LAG3 might be developed for treatment of primary liver cancer. ..

More Information

Publications109 found, 100 shown here

  1. Stankevicius V, Vasauskas G, Rynkeviciene R, Venius J, Pasukoniene V, Aleknavicius E, et al. Microenvironment and Dose-Delivery-Dependent Response after Exposure to Ionizing Radiation in Human Colorectal Cancer Cell Lines. Radiat Res. 2017;188:291-302 pubmed publisher
    ..Our results also indicated that cell line specific radiation response with or without activation of the conventional p53 pathway is ECM dependent, suggesting that the ECM is a key component in cellular radiation response. ..
  2. Johansson Percival A, He B, Li Z, Kjellén A, Russell K, Li J, et al. De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors. Nat Immunol. 2017;18:1207-1217 pubmed publisher
    The tumor microenvironment confers profound resistance to anti-cancer immunotherapy...
  3. Batlle E, Clevers H. Cancer stem cells revisited. Nat Med. 2017;23:1124-1134 pubmed publisher
    ..Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging...
  4. Seewaldt V. ECM stiffness paves the way for tumor cells. Nat Med. 2014;20:332-3 pubmed publisher
  5. Sehgal A, Boyiadzis M. AML treatment in older adults. Aging (Albany NY). 2015;7:611-2 pubmed
  6. Katlinski K, Gui J, Katlinskaya Y, Ortiz A, Chakraborty R, Bhattacharya S, et al. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell. 2017;31:194-207 pubmed publisher
    ..tumors, including colorectal cancers (CRCs), to immunotherapies is attributed to the immunosuppressive tumor microenvironment that protects malignant cells from cytotoxic T lymphocytes (CTLs)...
  7. Kim S, Jung K, Son M, Park J, Yan H, Fang Z, et al. Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery. Cancer Lett. 2017;403:339-353 pubmed publisher
  8. Mlecnik B, Van Den Eynde M, Bindea G, Church S, Vasaturo A, Fredriksen T, et al. Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival. J Natl Cancer Inst. 2018;110: pubmed publisher
    ..Response to treatment and prolonged survival of metastatic CRC patients were statistically significantly associated with high-immune densities quantified into the least immune-infiltrated metastasis. ..
  9. Hosseini F, Hassannia H, Mahdian Shakib A, Jadidi Niaragh F, Enderami S, Fattahi M, et al. Targeting of crosstalk between tumor and tumor microenvironment by ?-D mannuronic acid (M2000) in murine breast cancer model. Cancer Med. 2017;6:640-650 pubmed publisher
    ..Inflammatory processes following crosstalk between tumor cells and tumor microenvironment play an important role in progression and metastasis of cancer...
  10. Xie H, Shao Z, Li D. Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis. Chin J Cancer. 2017;36:36 pubmed publisher
    ..Here, we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis; we also discuss potential therapeutic intervention strategies aimed at ..
  11. Deshmukh S, Srivastava S, Tyagi N, Ahmad A, Singh A, Ghadhban A, et al. Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: a closer look at the surroundings. Carcinogenesis. 2017;38:757-765 pubmed publisher
    ..b>Tumor microenvironment, which provides a favorable niche for the growth of tumor cells, is comprised of several types of stromal ..
  12. Wei H, Xu Z, Liu F, Wang F, Wang X, Sun X, et al. Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition. Tumour Biol. 2017;39:1010428317691684 pubmed publisher
    ..Therefore, yes-associated protein 1 may serve as a novel promising target to enhance therapeutic effects for treating pancreatic cancer. ..
  13. Feng M, Xiong G, Cao Z, Yang G, Zheng S, Song X, et al. PD-1/PD-L1 and immunotherapy for pancreatic cancer. Cancer Lett. 2017;407:57-65 pubmed publisher
  14. Dowell A, Cobby E, Wen K, Devall A, During V, Anderson J, et al. Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer. PLoS ONE. 2017;12:e0184841 pubmed publisher
    ..Thus, in the context of bladder CIS, IL-17+ mast cells predict favourable outcome following BCG immunotherapy indicative of a novel mechanism of BCG immunotherapy in UBC and could form the basis of a stratified approach to treatment. ..
  15. Shpilberg Y, Connor M, Riddell M. The direct and indirect effects of corticosterone and primary adipose tissue on MCF7 breast cancer cell cycle progression. Horm Mol Biol Clin Investig. 2015;22:91-100 pubmed publisher
    ..The direct inhibitory effects of CORT on cancer cell cycle progression are largely limited by the hormone's effects on adipose tissue biology. ..
  16. Palm W, Thompson C. Nutrient acquisition strategies of mammalian cells. Nature. 2017;546:234-242 pubmed publisher
    ..We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells. ..
  17. Tod J, Hanley C, Morgan M, Rucka M, Mellows T, Lopez M, et al. Pro-migratory and TGF-?-activating functions of ?v?6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch. J Pathol. 2017;243:37-50 pubmed publisher
    ..2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
  18. Maishi N, Hida K. Tumor endothelial cells accelerate tumor metastasis. Cancer Sci. 2017;108:1921-1926 pubmed publisher
    ..Tumor stromal cells, which acquire their specific characteristics in the tumor microenvironment, accelerate tumor malignancy...
  19. Qing Y, Gerson S. Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells. PLoS ONE. 2017;12:e0182175 pubmed publisher
  20. Carbone A, Gloghini A. The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies. Blood. 2013;122:459-60 pubmed publisher
  21. Liu S, Tsang N, Chiang W, Chang K, Hsueh C, Liang Y, et al. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest. 2013;123:5269-83 pubmed publisher
    ..Together, our findings indicate that LIF promotes NPC tumorigenesis and suggest that serum LIF levels may predict local recurrence and radiosensitivity in NPC patients. ..
  22. Banerjee D, Kadenhe Chiweshe A, Yamashiro D. Inhibition of Notch promotes liver metastasis. Aging (Albany NY). 2015;7:603-4 pubmed
  23. Gandellini P, Doldi V, Zaffaroni N. microRNAs as players and signals in the metastatic cascade: Implications for the development of novel anti-metastatic therapies. Semin Cancer Biol. 2017;44:132-140 pubmed publisher
    ..miRNAs also actively participate in the proficient interaction of cancer cells with tumor microenvironment, either at the primary or at the metastatic site...
  24. Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman D, et al. IFN-?-related mRNA profile predicts clinical response to PD-1 blockade. J Clin Invest. 2017;127:2930-2940 pubmed publisher
    ..The T cell-inflamed GEP has been developed into a clinical-grade assay that is currently being evaluated in ongoing pembrolizumab trials. ..
  25. He W, Berardi E, Cardillo V, Acharyya S, Aulino P, Thomas Ahner J, et al. NF-?B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest. 2013;123:4821-35 pubmed
    ..Together, these results suggest that Pax7 responds to NF-?B by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer. ..
  26. Toor S, Syed Khaja A, El Salhat H, Faour I, Kanbar J, Quadri A, et al. Myeloid cells in circulation and tumor microenvironment of breast cancer patients. Cancer Immunol Immunother. 2017;66:753-764 pubmed publisher
    ..Nevertheless, expansion of MDSC has been reported in periphery and tumor microenvironment of various cancers...
  27. Umansky V, Blattner C, Gebhardt C, Utikal J. CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma. Cancer Immunol Immunother. 2017;66:1015-1023 pubmed publisher
    Malignant melanoma is characterized by the development of chronic inflammation in the tumor microenvironment, leading to the accumulation of myeloid-derived suppressor cells (MDSCs)...
  28. Khan M, Azim S, Zubair H, Bhardwaj A, Patel G, Khushman M, et al. Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward. Int J Mol Sci. 2017;18: pubmed publisher
    ..We also discuss the impact of the tumor microenvironment on the molecular landscape of PC and its role in aggressive disease progression...
  29. Han Y, Wu C, Wang J, Liu N. CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment. Tumour Biol. 2017;39:1010428317701631 pubmed publisher
    ..Therefore, inhibiting both CXCR4 and CXCR7 could be a promising strategy in controlling osteosarcoma invasion. ..
  30. Thomas T, Yu J. Metabolic regulation of glioma stem-like cells in the tumor micro-environment. Cancer Lett. 2017;408:174-181 pubmed publisher
    ..it is important to consider the inevitably heterogeneous metabolic components of the tumor and the tumor microenvironment. High grade gliomas remain one of the most difficult to treat solid tumors, due in part to the highly ..
  31. Gabay M, Li Y, Felsher D. MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harb Perspect Med. 2014;4: pubmed publisher
    ..Additionally, MYC orchestrates changes in the tumor microenvironment, including the activation of angiogenesis and suppression of the host immune response...
  32. Ritsma L, Dey Guha I, Talele N, Sole X, Salony -, Chowdhury J, et al. Integrin ?1 activation induces an anti-melanoma host response. PLoS ONE. 2017;12:e0175300 pubmed publisher
    ..cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironment. Here, we find that in melanoma, integrin ?1-mediated TGF-? activation may also produce tumor suppression ..
  33. Cairns R, Mak T. Fire and water: Tumor cell adaptation to metabolic conditions. Exp Cell Res. 2017;356:204-208 pubmed publisher
    ..This metabolic stress can be thought of as a fire that tumor cells must douse with enough water to survive, and may offer opportunities to exploit smoldering vulnerabilities in order to eradicate malignant cells. ..
  34. Miller T, Liau B, Wallace L, Morton A, Xie Q, Dixit D, et al. Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature. 2017;547:355-359 pubmed publisher
  35. Sarkar S, Bristow C, Dey P, Rai K, Perets R, Ramirez Cardenas A, et al. PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017;31:1109-1121 pubmed publisher
    ..activity of PRKCI relates in part to the up-regulation of TNFα to promote an immune-suppressive tumor microenvironment characterized by an abundance of myeloid-derived suppressor cells and inhibition of cytotoxic T-cell ..
  36. Xu C, Han X, Jiang Y, Yuan S, Wu Z, Wu Z, et al. Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels. Bioconjug Chem. 2017;28:2530-2537 pubmed publisher
  37. Zahalka A, Arnal Estapé A, Maryanovich M, Nakahara F, Cruz C, Finley L, et al. Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science. 2017;358:321-326 pubmed publisher
    ..Recent work suggests that newly formed nerve fibers may regulate the tumor microenvironment, but their exact functions are unclear...
  38. Bongiorno E, Garcia S, Sauma S, Hooper D. Type 1 Immune Mechanisms Driven by the Response to Infection with Attenuated Rabies Virus Result in Changes in the Immune Bias of the Tumor Microenvironment and Necrosis of Mouse GL261 Brain Tumors. J Immunol. 2017;198:4513-4523 pubmed publisher
    ..M2 cell products contribute to the growth-promoting attributes of the tumor microenvironment (TME) and bias immunity toward type 2, away from the type 1 mechanisms with antitumor properties...
  39. Walenkamp A, Lapa C, Herrmann K, Wester H. CXCR4 Ligands: The Next Big Hit?. J Nucl Med. 2017;58:77S-82S pubmed publisher
    ..and to sensitize cancer cells to conventional chemotherapy and radiotherapy, and the potential to overcome tumor microenvironment-driven immunosuppression is being explored...
  40. Ribas A, Dummer R, Puzanov I, VanderWalde A, Andtbacka R, Michielin O, et al. Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy. Cell. 2017;170:1109-1119.e10 pubmed publisher
    ..These findings suggest that oncolytic virotherapy may improve the efficacy of anti-PD-1 therapy by changing the tumor microenvironment. VIDEO ABSTRACT.
  41. Barnes T, Amir E. HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer. Br J Cancer. 2017;117:451-460 pubmed publisher
    ..The inhibitory function of other immune cells, for example, myeloid-derived suppressor cells and regulatory T cells, appear to have a major role in disrupting the capacity for the immune control of cancers. ..
  42. Szabo A, Merks R. Blood vessel tortuosity selects against evolution of aggressive tumor cells in confined tissue environments: A modeling approach. PLoS Comput Biol. 2017;13:e1005635 pubmed publisher
    ..This provides new insights into potential side effects of recent tumor vasculature normalization approaches. ..
  43. Bakker E, Guazzelli A, Ashtiani F, Demonacos C, Krstic Demonacos M, Mutti L. Immunotherapy advances for mesothelioma treatment. Expert Rev Anticancer Ther. 2017;17:799-814 pubmed publisher
    ..Lastly, clinical trials should focus on overall survival rather than surrogate endpoints to avoid bias and inaccurate reflections of treatment effects. ..
  44. Strom T, Harrison L, Giuliano A, Schell M, Eschrich S, Berglund A, et al. Tumour radiosensitivity is associated with immune activation in solid tumours. Eur J Cancer. 2017;84:304-314 pubmed publisher
    ..63 [95% confidence interval 0.36, 1.09]) and 12-CK (HR 0.66 [0.41, 1.04]) each providing comparable contributions. Tumour radiosensitivity is associated with immune activation as measured by the two GESs. ..
  45. Ueno H, Kanemitsu Y, Sekine S, Ishiguro M, Ito E, Hashiguchi Y, et al. Desmoplastic Pattern at the Tumor Front Defines Poor-prognosis Subtypes of Colorectal Cancer. Am J Surg Pathol. 2017;41:1506-1512 pubmed publisher
    ..To our knowledge, this is the first study reporting a greater prognostic power of histology of the fibrotic stroma than that of tumor factors. ..
  46. Guo X, Zhu S, Brunner A, van de Rijn M, West R. Next generation sequencing-based expression profiling identifies signatures from benign stromal proliferations that define stromal components of breast cancer. Breast Cancer Res. 2013;15:R117 pubmed publisher
    Multiple studies have shown that the tumor microenvironment (TME) of carcinomas can play an important role in the initiation, progression, and metastasis of cancer...
  47. Kosaka N, Yoshioka Y, Fujita Y, Ochiya T. Versatile roles of extracellular vesicles in cancer. J Clin Invest. 2016;126:1163-72 pubmed publisher
    ..Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells. ..
  48. Syed Khaja A, Toor S, El Salhat H, Faour I, Ul Haq N, Ali B, et al. Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment. Oncotarget. 2017;8:33159-33171 pubmed publisher
    ..In the present study, we phenotypically characterize different Treg subsets infiltrating the tumor microenvironment (TME), compared to adjacent normal tissue and peripheral blood of primary breast cancer (PBC) patients...
  49. Xerri L, Huet S, Venstrom J, Szafer Glusman E, Fabiani B, Canioni D, et al. Rituximab treatment circumvents the prognostic impact of tumor-infiltrating T-cells in follicular lymphoma patients. Hum Pathol. 2017;64:128-136 pubmed publisher
    ..These results suggest that the IHC prognostic value of TILs is circumvented by rituximab treatment, although there is a trend for high numbers of CD3+ TILs to correlate with better PFS. ..
  50. Kolonin M, Sergeeva A, Staquicini D, Smith T, Tarleton C, Molldrem J, et al. Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone. Cancer Res. 2017;77:3144-3150 pubmed publisher
    ..i>Cancer Res; 77(12); 3144-50. ©2017 AACR. ..
  51. Qiu G, Jin M, Dai J, Sun W, Feng J, Jin W. Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies. Trends Pharmacol Sci. 2017;38:669-686 pubmed publisher
  52. Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Hatano T, et al. Using TILs to Predict Therapeutic Effect of Chemotherapy (Pertuzumab, Trastuzumab, Docetaxel) on HER2-positive Breast Cancer. Anticancer Res. 2017;37:5623-5630 pubmed
    ..We evaluated that chemotherapy with a TPD regimen (trastuzumab, pertuzumab, docetaxel) against HER2-positive breast cancer, using TILs as indicators...
  53. Ostman A. Cancer-associated fibroblasts: recent developments and emerging challenges. Semin Cancer Biol. 2014;25:1-2 pubmed publisher
  54. Anderson K, Stromnes I, Greenberg P. Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies. Cancer Cell. 2017;31:311-325 pubmed publisher
    ..Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity...
  55. Peinado H, Zhang H, Matei I, Costa Silva B, Hoshino A, Rodrigues G, et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17:302-317 pubmed publisher
    ..In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche...
  56. Kasashima H, Yashiro M, Nakamae H, Masuda G, Kinoshita H, Morisaki T, et al. Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma. PLoS ONE. 2017;12:e0178635 pubmed publisher
    ..The expressions of CXCL1 in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients. ..
  57. Gao Y, Lin P, Lydon J, Li Q. Conditional abrogation of transforming growth factor-? receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice. J Pathol. 2017;243:89-99 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  58. Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, et al. Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy. PLoS ONE. 2017;12:e0179431 pubmed publisher
    ..NKTR-214 treatment in vivo favors activation of CD8 T cells over Tregs in the tumor microenvironment to provide anti-tumor efficacy in multiple syngeneic models...
  59. Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, et al. Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration. Eur J Immunol. 2017;47:1562-1572 pubmed publisher
    ..Under in vitro conditions mimicking a tumor microenvironment, we show that PFN1 downregulation promotes CTL invasion into a 3D matrix, without affecting the viability ..
  60. Sakimura C, Tanaka H, Okuno T, Hiramatsu S, Muguruma K, Hirakawa K, et al. B cells in tertiary lymphoid structures are associated with favorable prognosis in gastric cancer. J Surg Res. 2017;215:74-82 pubmed publisher
    The role of tumor-infiltrating B cells in the tumor microenvironment is still unclear...
  61. Bai Y, Hsia Y, Lin Y, Chen K, Chou F, Yang C, et al. Effect of Tumor Microenvironment on Selective Uptake of Boric Acid in HepG2 Human Hepatoma Cells. Anticancer Res. 2017;37:6347-6353 pubmed
    ..Furthermore, selective uptake of BA by liver tumor cells was shown in a rabbit model. To gain further insight, this study aimed to investigate the mechanisms of transportation and selective uptake of BA in HepG2 liver tumor cells...
  62. Radisky D, Nelson C. Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. Oncotarget. 2013;4:498-9 pubmed
  63. Wani N, Nasser M, Ahirwar D, Zhao H, Miao Z, Shilo K, et al. C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment. Breast Cancer Res. 2014;16:R54 pubmed publisher
    ..reveal that CXCR7 enhances breast cancer growth and metastasis via a novel pathway by modulating the tumor microenvironment. These findings identify CXCR7-mediated STAT3 activation and modulation of the tumor microenvironment as ..
  64. Allard B, Longhi M, Robson S, Stagg J. The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev. 2017;276:121-144 pubmed publisher
    ..Finally, we provide insights into potential clinical application of adenosinergic and other purinergic-targeting therapies and forecast how these might develop in combination with other anti-cancer modalities...
  65. Von Ahrens D, Bhagat T, Nagrath D, Maitra A, Verma A. The role of stromal cancer-associated fibroblasts in pancreatic cancer. J Hematol Oncol. 2017;10:76 pubmed publisher
  66. Jiang X, Elliott R. Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells. Anticancer Res. 2017;37:2297-2305 pubmed
    ..Conversely, a decrease in iron concentration caused by DFOM improves natural killer cytolysis of tumor cells. ..
  67. Jinushi M, Morita T, Xu Z, Kinoshita I, Dosaka Akita H, Yagita H, et al. Autophagy-dependent regulation of tumor metastasis by myeloid cells. PLoS ONE. 2017;12:e0179357 pubmed publisher
    ..Taken together, our findings elucidate previously unrecognized mechanisms by which myeloid cells promote tumor progression through autophagy-mediated regulation of malignancy and immune tolerance. ..
  68. Ramos A, Hemann M. Drugs, Bugs, and Cancer: Fusobacterium nucleatum Promotes Chemoresistance in Colorectal Cancer. Cell. 2017;170:411-413 pubmed publisher
    The tumor microenvironment has recently been shown to play decisive roles in chemotherapeutic response. In this issue of Cell, Yu et al...
  69. McGranahan N, Swanton C. Cancer Evolution Constrained by the Immune Microenvironment. Cell. 2017;170:825-827 pubmed publisher
    ..These complex interactions are highlighted in this issue of Cell by the results from Jiménez-Sánchez et al. of a deep analysis of one patient with advanced serous carcinoma of the ovary. ..
  70. Goossens N, Hoshida Y, Aguirre Ghiso J. Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance. EMBO Mol Med. 2015;7:1385-7 pubmed publisher
  71. Yang D, Cao X, Wang F, Jiang H, Feng D, Guo H, et al. LFG-500, a novel synthetic flavonoid, suppresses epithelial-mesenchymal transition in human lung adenocarcinoma cells by inhibiting NLRP3 in inflammatory microenvironment. Cancer Lett. 2017;400:137-148 pubmed publisher
    ..Together, these results suggest that LFG-500 markedly suppresses EMT by inhibiting the NLRP3 inflammasome in the inflammatory microenvironment and that NLRP3 is a potential biomarker of lung adenocarcinoma metastasis. ..
  72. Acuff N, Linden J. Using Visualization of t-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors. J Immunol. 2017;198:4539-4546 pubmed publisher
    ..Additionally, both CD8+ T cells and CD8+ dendritic cells were identified in the tumor microenvironment. Apparent differences between splenic and tumor polymorphonuclear cells/granulocytic myeloid-derived ..
  73. Cogdill A, Andrews M, Wargo J. Hallmarks of response to immune checkpoint blockade. Br J Cancer. 2017;117:1-7 pubmed publisher
    ..Evolution of this understanding will ultimately help guide treatment strategies to enhance therapeutic responses...
  74. Pradeep P, Kumar P, Choonara Y, Pillay V. Targeted nanotechnologies for cancer intervention: a patent review (2010-2016). Expert Opin Ther Pat. 2017;27:1005-1019 pubmed publisher
    ..techniques, predictive animal/pre-clinical models, maximal utilisation of extra- and intracellular tumor microenvironment for drug delivery, and exploring the metabolomic-, proteomic-, and genomic-based personalization of cancer ..
  75. Hagner P, Chiu H, ORTIZ M, Apollonio B, Wang M, Couto S, et al. Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity. Br J Haematol. 2017;179:399-409 pubmed publisher
    ..Taken together, these data provide the first insight into the clinical activity of lenalidomide against MCL, revealing a predominately immune-mediated MOA. ..
  76. Yogev O, Henderson S, Hayes M, Marelli S, Ofir Birin Y, Regev Rudzki N, et al. Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs. PLoS Pathog. 2017;13:e1006524 pubmed publisher
    ..We suggest that viruses and cancer cells use this mechanism to shape a specific metabolic niche that will contribute to their fitness. ..
  77. Parr E. The default state of the cell: quiescence or proliferation?. Bioessays. 2012;34:36-7 pubmed publisher
  78. Stefka A, Park J, Matsuo Y, Chung S, Nakamura Y, Jakubowiak A, et al. Anti-myeloma activity of MELK inhibitor OTS167: effects on drug-resistant myeloma cells and putative myeloma stem cell replenishment of malignant plasma cells. Blood Cancer J. 2016;6:e460 pubmed publisher
  79. Jamshidi N, Margolis D, Raman S, Huang J, Reiter R, Kuo M. Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR Imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma. Radiology. 2017;284:109-119 pubmed publisher
    ..sup>© RSNA, 2017 Online supplemental material is available for this article. ..
  80. Curry J, Tassone P, Gill K, Tuluc M, BarAd V, Mollaee M, et al. Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2017;157:798-807 pubmed publisher
    ..Greater cancer-associated stromal conversion around ECE, denoted by high stromal MCT4, may be a biomarker for aggressive disease and worsened DFS. ..
  81. Park S, Surh Y. Modulation of tumor microenvironment by chemopreventive natural products. Ann N Y Acad Sci. 2017;1401:65-74 pubmed publisher
    The tumor microenvironment provides a niche in which cancer cells and their surrounding stromal cells reside and in which their interactions occur...
  82. Nirschl C, Suárez Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, et al. IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017;170:127-141.e15 pubmed publisher
    ..These findings link immune homeostasis to key determinants of anti-tumoral immunity and escape, revealing co-opting of tissue-specific immune development in the tumor microenvironment.
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