s phase cell cycle checkpoints


Summary: Cell regulatory signaling system that controls progression through S PHASE and stabilizes the replication forks during conditions that could affect the fidelity of DNA REPLICATION, such as DNA DAMAGE or depletion of nucleotide pools.

Top Publications

  1. Huang Z, Wang L, Chen L, Zhang Y, Shi P. Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol. Acta Pharm. 2015;65:463-71 pubmed publisher
    ..This suggests that clioquinol may have a therapeutic potential as an anticancer drug for certain malignances. ..
  2. Giannattasio M, Branzei D. S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion. Cell Mol Life Sci. 2017;74:2361-2380 pubmed publisher
    ..This review summarizes the various functions of the replication checkpoint in promoting replication fork stability and genome integrity in the face of replication stress caused by dNTP depletion. ..
  3. He L, Chen Y, Feng J, Sun W, Li S, Ou M, et al. Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway. Int J Biochem Cell Biol. 2017;90:29-37 pubmed publisher
    ..These results indicated that BAF57, BAF60a and SNF5 might act as novel pro-senescence factors in both normal and tumor human skin cells. Therefore, inhibiting expression of the three factors might delay the cellular senescence process. ..
  4. Mombach J, Bugs C, Chaouiya C. Modelling the onset of senescence at the G1/S cell cycle checkpoint. BMC Genomics. 2014;15 Suppl 7:S7 pubmed publisher
    ..This model qualitatively agrees with most experimental observations, including experiments involving mutations. Furthermore, it provides some predictions. ..
  5. Li Y, Fan L, Niu Y, Mian W, Zhang F, Xie M, et al. An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer. Eur J Pharmacol. 2017;804:13-20 pubmed publisher
    ..Taken together, the combinatorial therapy using AOG and 5-FU is a promising strategy for the treatment of colorectal cancer. ..
  6. Glück S, Buttafuoco A, Meier A, Arnoldi F, Vogt B, Schraner E, et al. Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle. PLoS ONE. 2017;12:e0179607 pubmed publisher
    ..We used a MA104-Fucci system to identify three RV proteins (NSP3, NSP5, and VP2) involved in cell cycle arrest in the S-phase. Our data indicate that there is a strong correlation between the cell cycle arrest and RV replication. ..
  7. Sivanand S, Rhoades S, Jiang Q, Lee J, Benci J, Zhang J, et al. Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell. 2017;67:252-265.e6 pubmed publisher
    ..Upon PARP inhibition, ACLY silencing promotes genomic instability and cell death. Thus, the spatial and temporal control of acetyl-CoA production by ACLY participates in the mechanism of DNA repair pathway choice. ..
  8. Jiang L, Zhao Z, Zheng L, Xue L, Zhan Q, Song Y. Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1. Genomics Proteomics Bioinformatics. 2017;15:208-217 pubmed publisher
    ..Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1. ..
  9. Zhang G, Yuan J, Qian G, Gu C, Wei K, Mo D, et al. Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells. J Med Chem. 2017;60:6853-6866 pubmed publisher
    ..Our present studies furnish new insights into the molecular interactions and anticancer mechanisms of phospho-p53-dependent quinazolinone compound. ..

More Information


  1. Jiao Y, Ding L, Chu M, Wang T, Kang J, Zhao X, et al. Effects of cancer-testis antigen, TFDP3, on cell cycle regulation and its mechanism in L-02 and HepG2 cell lines in vitro. PLoS ONE. 2017;12:e0182781 pubmed publisher
    ..By knocking down the TFDP3 expression level in L-02 and HepG2 cell lines, the cell cycle would be arrested in S phase, which confirmed that TFDP3 can be a potential target for tumor therapy. ..
  2. Marques Ramos A, Candeias M, Menezes J, Lacerda R, Willcocks M, Teixeira A, et al. Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition. RNA. 2017;23:1712-1728 pubmed publisher
    ..These results suggest a novel regulatory mechanism for mTOR gene expression that integrates the global protein synthesis changes induced by translational inhibitory conditions. ..
  3. Sun C, Ma P, Wang Y, Liu W, Chen Q, Pan Y, et al. KLF15 Inhibits Cell Proliferation in Gastric Cancer Cells via Up-Regulating CDKN1A/p21 and CDKN1C/p57 Expression. Dig Dis Sci. 2017;62:1518-1526 pubmed publisher
    ..These findings demonstrate that KLF15 plays a significant role in GC progression and could be a therapeutic target for GC. ..
  4. Preya U, Lee K, Kim N, Lee J, Jang D, Choi J. The natural terthiophene ?-terthienylmethanol induces S phase cell cycle arrest of human ovarian cancer cells via the generation of ROS stress. Chem Biol Interact. 2017;272:72-79 pubmed publisher
    ..These results suggest that ?-terthienylmethanol inhibits the growth of human ovarian cancer cells by S phase cell cycle arrest via induction of ROS stress and DNA damage. ..
  5. Zhang L, Dewan V, Yin H. Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. J Med Chem. 2017;60:5029-5044 pubmed publisher
    ..These results showcase potential therapeutic applications of 17e in both vaccine adjuvants and anticancer therapies based on multi-TLR activation. ..
  6. Iyer D, Rhind N. Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA. PLoS Genet. 2017;13:e1006958 pubmed publisher
    ..Finally, using a novel analytic approach, we rigorously identify fork stalling events in our combing data and show that they play a previously unappreciated role in shaping replication kinetics in response to DNA damage. ..