interphase

Summary

Summary: The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).

Top Publications

  1. Santos A, Ferreira L, Maroco J, Oliveira M. Abiotic stress and induced DNA hypomethylation cause interphase chromatin structural changes in rice rDNA loci. Cytogenet Genome Res. 2011;132:297-303 pubmed publisher
    ..We investigated the interphase chromatin organization from rice plants in non-stress versus stress conditions...
  2. Bernad R, Sanchez P, Rivera T, Rodríguez Corsino M, Boyarchuk E, Vassias I, et al. Xenopus HJURP and condensin II are required for CENP-A assembly. J Cell Biol. 2011;192:569-82 pubmed publisher
    ..required for CENP-A assembly and contributes to retention of centromeric CENP-A nucleosomes both in mitosis and interphase. We propose that the chromatin structure imposed by condensin II at centromeres enables CENP-A incorporation ..
  3. Ozlu N, Monigatti F, Renard B, Field C, Steen H, Mitchison T, et al. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010;9:336-50 pubmed publisher
    ..Concretely, we report a central role for Aurora-B in regulating the C phase cytoskeleton. ..
  4. Dultz E, Ellenberg J. Live imaging of single nuclear pores reveals unique assembly kinetics and mechanism in interphase. J Cell Biol. 2010;191:15-22 pubmed publisher
    ..cell cycle stages: at the end of mitosis concomitant with the reformation of the nuclear envelope and during interphase. However, the mechanisms of these assembly processes may differ...
  5. Goodwin S, Vale R. Patronin regulates the microtubule network by protecting microtubule minus ends. Cell. 2010;143:263-74 pubmed publisher
    ..minus ends lose subunits through the actions of the Kinesin-13 microtubule depolymerase, leading to a sparse interphase microtubule array and short, disorganized mitotic spindles...
  6. Buster D, Daniel S, Nguyen H, Windler S, Skwarek L, Peterson M, et al. SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2. J Cell Biol. 2013;201:49-63 pubmed publisher
    ..cell cycle and, in addition to its mitotic duties, modulates chromosome organization and gene expression during interphase. Mitotic condensin activity is regulated by phosphorylation, but mechanisms that regulate condensin II during ..
  7. Hayashi Takanaka Y, Yamagata K, Nozaki N, Kimura H. Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase. J Cell Biol. 2009;187:781-90 pubmed publisher
    ..In contrast, in nontransformed cells, phosphorylated H3S10 foci appear for a few hours during interphase, and transient exposure to an aurora B-selective inhibitor during this period induces chromosome missegregation...
  8. Ray S, Kume K, Gupta S, Ge W, Balasubramanian M, Hirata D, et al. The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe. J Cell Biol. 2010;190:793-805 pubmed publisher
    The mechanisms that regulate cytoskeletal remodeling during the transition between mitosis and interphase are poorly understood...
  9. van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia S, Bjelic S, et al. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J Cell Biol. 2011;193:1083-99 pubmed publisher
    ..ch-TOG accumulation at MT plus ends and, as a consequence, strongly stimulated processive MT polymerization in interphase cells. Depletion or disruption of the SLAIN2-ch-TOG complex led to disorganization of the radial MT array...

More Information

Publications62

  1. Lee Y, Kim E, Park M, Moon E, Ahn S, Kim W, et al. Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. Gene. 2010;466:16-25 pubmed publisher
    ..that the KIF18B protein is present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells...
  2. Funakoshi T, Clever M, Watanabe A, Imamoto N. Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly. Mol Biol Cell. 2011;22:1058-69 pubmed publisher
    ..NPCs assemble twice during the cell cycle in metazoans: postmitosis and during interphase. In this study, using small interfering RNA (siRNA) in conjunction with a cell fusion-based NPC assembly assay, ..
  3. Schubert I, Shaw P. Organization and dynamics of plant interphase chromosomes. Trends Plant Sci. 2011;16:273-81 pubmed publisher
    Eukaryotic chromosomes occupy distinct territories within interphase nuclei. The arrangement of chromosome territories (CTs) is important for replication, transcription, repair and recombination processes...
  4. Bridger J. Chromobility: the rapid movement of chromosomes in interphase nuclei. Biochem Soc Trans. 2011;39:1747-51 pubmed publisher
    ..number of studies reporting the movement of gene loci and whole chromosomes to new compartments within interphase nuclei...
  5. Rosa A, Becker N, Everaers R. Looping probabilities in model interphase chromosomes. Biophys J. 2010;98:2410-9 pubmed publisher
    ..capture (3C) are two powerful techniques for investigating the three-dimensional organization of the genome in interphase nuclei...
  6. Elcock L, Bridger J. Exploring the relationship between interphase gene positioning, transcriptional regulation and the nuclear matrix. Biochem Soc Trans. 2010;38:263-7 pubmed publisher
    ..in situ hybridization), there have been major advances in our understanding of how the genome is organized in interphase nuclei...
  7. Sampathkumar A, Gutierrez R, McFarlane H, Bringmann M, Lindeboom J, Emons A, et al. Patterning and lifetime of plasma membrane-localized cellulose synthase is dependent on actin organization in Arabidopsis interphase cells. Plant Physiol. 2013;162:675-88 pubmed publisher
    ..Hence, both actin and microtubule cytoskeletons play important roles in regulating CesA trafficking, cellulose deposition, and organization of cell wall biogenesis...
  8. Almonacid M, Moseley J, Janvore J, Mayeux A, Fraisier V, Nurse P, et al. Spatial control of cytokinesis by Cdr2 kinase and Mid1/anillin nuclear export. Curr Biol. 2009;19:961-6 pubmed publisher
    ..Here we show that Cdr2 kinase anchors Mid1 at the medial cortex during interphase through association with the Mid1 N terminus...
  9. Jerabek H, Heermann D. Expression-dependent folding of interphase chromatin. PLoS ONE. 2012;7:e37525 pubmed publisher
    ..To investigate the interplay between the conformation of interphase chromatin and its transcriptional activity, we include information from gene expression profiles into a polymer ..
  10. Loncarek J, Hergert P, Khodjakov A. Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1. Curr Biol. 2010;20:1277-82 pubmed publisher
    ..in some transformed cells, centrioles undergo multiple rounds of duplication (reduplication) during prolonged interphase. Mechanisms responsible for centriole reduplication are poorly understood...
  11. Lee Y, Geckeler K. Carbon nanotubes in the biological interphase: the relevance of noncovalence. Adv Mater. 2010;22:4076-83 pubmed publisher
    ..the increasing interest in the biological applications of carbon nanotubes, their interactions in the biological interphase and their general cytotoxicity have become major issues...
  12. Wong H, Marie Nelly H, Herbert S, Carrivain P, Blanc H, Koszul R, et al. A predictive computational model of the dynamic 3D interphase yeast nucleus. Curr Biol. 2012;22:1881-90 pubmed publisher
    ..We present a computational model of dynamic chromosome configurations in the interphase yeast nucleus that is based on first principles and is able to statistically predict the positioning of any ..
  13. Foster H, Griffin D, Bridger J. Interphase chromosome positioning in in vitro porcine cells and ex vivo porcine tissues. BMC Cell Biol. 2012;13:30 pubmed publisher
    In interphase nuclei of a wide range of species chromosomes are organised into their own specific locations termed territories...
  14. Johansson H, Svensson F, Runnberg R, Simonsson T, Simonsson S. Phosphorylated nucleolin interacts with translationally controlled tumor protein during mitosis and with Oct4 during interphase in ES cells. PLoS ONE. 2010;5:e13678 pubmed publisher
    ..In addition, we showed that Ncl-P interacted with the transcription factor Oct4 during interphase in human as well as murine ES cells, indicating of a role in transcription...
  15. Zidovska A, Weitz D, Mitchison T. Micron-scale coherence in interphase chromatin dynamics. Proc Natl Acad Sci U S A. 2013;110:15555-60 pubmed publisher
    ..We observe similar trends in chromatin dynamics upon inducing a direct DNA damage; thus we hypothesize that this may be due to DNA damage responses that physically relax chromatin and block long-distance communication of forces. ..
  16. Kustatscher G, Hegarat N, Wills K, Furlan C, Bukowski Wills J, Hochegger H, et al. Proteomics of a fuzzy organelle: interphase chromatin. EMBO J. 2014;33:648-64 pubmed publisher
    ..So far, a comprehensive inventory of interphase chromatin has not been determined...
  17. Ribeiro Mason K, Boulesteix C, Fleurot R, Aguirre Lavin T, Adenot P, Gall L, et al. H3S10 phosphorylation marks constitutive heterochromatin during interphase in early mouse embryos until the 4-cell stage. J Reprod Dev. 2012;58:467-75 pubmed
  18. Yanagida M. Clearing the way for mitosis: is cohesin a target?. Nat Rev Mol Cell Biol. 2009;10:489-96 pubmed publisher
    In interphase, chromosomes are associated with proteins and RNAs that participate in many processes, such as DNA replication, transcription, recombination and repair of DNA damage...
  19. Vargas J, Hatch E, Anderson D, Hetzer M. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus. 2012;3:88-100 pubmed publisher
    ..a phenomenon wherein nuclei of several proliferating human cancer cell lines become temporarily ruptured during interphase. Strikingly, NE rupturing was associated with the mislocalization of nucleoplasmic and cytoplasmic proteins and, ..
  20. Olins A, Rhodes G, Welch D, Zwerger M, Olins D. Lamin B receptor: multi-tasking at the nuclear envelope. Nucleus. 2010;1:53-70 pubmed publisher
    Lamin B receptor (LBR) is an integral membrane protein of the interphase nuclear envelope (NE). The N-terminal end resides in the nucleoplasm, binding to lamin B and heterochromatin, with the interactions disrupted during mitosis...
  21. Roque H, Ward J, Murrells L, Brunner D, Antony C. The fission yeast XMAP215 homolog Dis1p is involved in microtubule bundle organization. PLoS ONE. 2010;5:e14201 pubmed publisher
    ..pombe is an ideal organism for studying the function and organization of microtubules into bundles in interphase cells...
  22. Abrahám E, Miskolczi P, Ayaydin F, Yu P, Kotogány E, Bako L, et al. Immunodetection of retinoblastoma-related protein and its phosphorylated form in interphase and mitotic alfalfa cells. J Exp Bot. 2011;62:2155-68 pubmed publisher
    ..Immunolocalization of the phospho-MsRBR protein indicated spots of variable number and size in the labelled interphase nuclei and high signal intensity of nuclear granules in prophase...
  23. Fazzio T, Panning B. Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. J Cell Biol. 2010;188:491-503 pubmed publisher
    ..that were unique to ES cells and unique among the ES cell-lethal targets: metaphase arrest and greatly enlarged interphase nuclei...
  24. Perez Cadahia B, Drobic B, Davie J. H3 phosphorylation: dual role in mitosis and interphase. Biochem Cell Biol. 2009;87:695-709 pubmed publisher
    ..The cellular contexts under which specific residues on H3 are phosphorylated in mitosis and interphase are known to some extent. However, the functional consequences of H3 phosphorylation are still unclear.
  25. Peter A, Heiden T, Taube T, Körner G, Seeger K. Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes. Eur J Haematol. 2009;83:420-32 pubmed publisher
    ..38 children with relapsed TEL/AML1 RT-PCR positive and negative BCP-ALL were analyzed for these mutations by interphase fluorescence in situ hybridization and results were compared with published data...
  26. Lim S, Kawamura E, Fielding A, Maydan M, Dedhar S. Integrin-linked kinase regulates interphase and mitotic microtubule dynamics. PLoS ONE. 2013;8:e53702 pubmed publisher
    ..Measurement of interphase microtubule dynamics revealed that ILK overexpression favored microtubule depolymerization, suggesting that ..
  27. Long J, Bagonis M, Lowery L, Lee H, Danuser G, Van Vactor D. Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Mol Cell Biol. 2013;33:1528-45 pubmed publisher
    ..Using these data, we identify subnetworks of proteins with novel yet overlapping MT-regulatory roles and also uncover subtle distinctions between the functions of proteins previously thought to act via similar mechanisms...
  28. Blobel G, Kadauke S, Wang E, Lau A, Zuber J, Chou M, et al. A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Mol Cell. 2009;36:970-83 pubmed publisher
    ..pattern of MLL occupancy during mitosis in a manner favoring genes that were highly transcribed during interphase. Knockdown experiments revealed that MLL retention at gene promoters during mitosis accelerates transcription ..
  29. Tolg C, Hamilton S, Morningstar L, Zhang J, Zhang S, Esguerra K, et al. RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity. J Biol Chem. 2010;285:26461-74 pubmed publisher
    ..Here, we report that intracellular RHAMM(Delta163) modifies the stability of interphase and mitotic spindle microtubules through ERK1/2 activity...
  30. Maciejowski J, George K, Terret M, Zhang C, Shokat K, Jallepalli P. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 2010;190:89-100 pubmed publisher
    ..such that cells completed mitosis in 12 min, and prevented Cdc20's association with either Mad2 or BubR1 during interphase, i.e., before the appearance of functional kinetochores...
  31. Tokuda N, Terada T, Sasai M. Dynamical modeling of three-dimensional genome organization in interphase budding yeast. Biophys J. 2012;102:296-304 pubmed publisher
    ..In this article, we develop a computational model of the three-dimensional organization of the haploid genome of interphase budding yeast by regarding chromosomes as chains moving under the constraints of nuclear structure and chromatin-..
  32. Olins A, Langhans M, Monestier M, Schlotterer A, Robinson D, Viotti C, et al. An epichromatin epitope: persistence in the cell cycle and conservation in evolution. Nucleus. 2011;2:47-60 pubmed publisher
    b>Interphase nuclear architecture is disrupted and rapidly reformed with each cell division cycle. Successive cell generations exhibit a "memory" of this nuclear architecture, as well as for gene expression...
  33. Muller I, Boyle S, Singer R, Bickmore W, Chubb J. Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells. PLoS ONE. 2010;5:e11560 pubmed publisher
    ..structure of mitotic chromosomes, it has not been possible to visualise individual chromosomes in living interphase cells, where chromosomes spend over 90% of their time...
  34. Hall L, Carone D, Gomez A, Kolpa H, Byron M, Mehta N, et al. Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes. Cell. 2014;156:907-19 pubmed publisher
    ..C0T-1-hybridizing RNA strictly localizes to the interphase chromosome territory in cis and remains stably associated with the chromosome territory following prolonged ..
  35. Hubert T, Vandekerckhove J, Gettemans J. Actin and Arp2/3 localize at the centrosome of interphase cells. Biochem Biophys Res Commun. 2011;404:153-8 pubmed publisher
    ..Here, we report the localization of actin at the centrosome in interphase but not in mitotic MDA-MB-231 cells...
  36. McCormick C, Akamatsu M, Ti S, Pollard T. Measuring affinities of fission yeast spindle pole body proteins in live cells across the cell cycle. Biophys J. 2013;105:1324-35 pubmed publisher
    ..During interphase these species have widely different affinities for their common receptor Cdc11p on the SPB...
  37. Dewald G, Smyrk T, Thorland E, McWilliams R, Van Dyke D, Keefe J, et al. Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. Mayo Clin Proc. 2009;84:801-10 pubmed publisher
    To use fluorescence in situ hybridization (FISH) to visualize genetic abnormalities in interphase cell nuclei (interphase FISH) of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas.
  38. Lerit D, Rusan N. PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells. J Cell Biol. 2013;202:1013-22 pubmed publisher
    ..This asymmetry produces one active and one inactive centrosome during interphase. We identify pericentrin-like protein (PLP) as a negative regulator of centrosome maturation and activity...
  39. Yenjerla M, Panopoulos A, Reynaud C, Fotedar R, Margolis R. TD-60 is required for interphase cell cycle progression. Cell Cycle. 2013;12:837-41 pubmed publisher
    ..We now report that TD-60 is an essential regulator of cell cycle progression during interphase. siRNA suppression blocks progression of mammalian G?/S phase cells and progression of G? cells into mitosis...
  40. Akamatsu M, Berro J, Pu K, Tebbs I, Pollard T. Cytokinetic nodes in fission yeast arise from two distinct types of nodes that merge during interphase. J Cell Biol. 2014;204:977-88 pubmed publisher
    ..Observations of cells expressing fluorescent fusion proteins revealed two types of interphase nodes...
  41. Kang E, Wu G, Ma H, Li Y, Tippner Hedges R, Tachibana M, et al. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014;509:101-4 pubmed publisher
    ..This led to the conclusion that critical oocyte reprogramming factors present in the metaphase but not in the interphase cytoplasm are 'trapped' inside the nucleus during interphase and effectively removed during enucleation...
  42. Hihara S, Pack C, Kaizu K, Tani T, Hanafusa T, Nozaki T, et al. Local nucleosome dynamics facilitate chromatin accessibility in living mammalian cells. Cell Rep. 2012;2:1645-56 pubmed publisher
    ..We show that similar to interphase chromatin, dense mitotic chromosomes also have considerable chromatin accessibility...
  43. Saha S, Pollard T. Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast. Mol Biol Cell. 2012;23:3982-92 pubmed publisher
    ..We conclude that orderly assembly of the contractile ring in wild-type cells depends on Mid1p to recruit myosin-II, Rng2p, and Cdc15p to nodes and to place cytokinetic nodes around the cell equator. ..
  44. Lakhal B, Braham R, Berguigua R, Bouali N, Zaouali M, Chaieb M, et al. Cytogenetic analyses of premature ovarian failure using karyotyping and interphase fluorescence in situ hybridization (FISH) in a group of 1000 patients. Clin Genet. 2010;78:181-5 pubmed publisher
    ..Chromosome analyses were performed by using karyotyping and interphase fluorescent in situ hybridisation (FISH) using a centromeric probe of the chromosome X to look for low-level ..
  45. Zaidi S, Young D, Montecino M, Lian J, Van Wijnen A, Stein J, et al. Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet. 2010;11:583-9 pubmed publisher
    Regulatory machinery is focally organized in the interphase nucleus...
  46. Zimmer C, Fabre E. Principles of chromosomal organization: lessons from yeast. J Cell Biol. 2011;192:723-33 pubmed publisher
    ..The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of ..
  47. Eichinger C, Kurze A, Oliveira R, Nasmyth K. Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis. EMBO J. 2013;32:656-65 pubmed publisher
    ..We show here that Wapl-dependent release from salivary gland polytene chromosomes during interphase and from neuroblast chromosome arms during prophase is blocked by translational fusion of Smc3's C-terminus to ..
  48. Schubert V, Berr A, Meister A. Interphase chromatin organisation in Arabidopsis nuclei: constraints versus randomness. Chromosoma. 2012;121:369-87 pubmed publisher
    ..We discuss the possible function of this conformation in comparison to transcriptionally active regions at insect polytene chromosomes. ..
  49. Jourdan N, Jobart Malfait A, Dos Reis G, Quignon F, Piolot T, Klein C, et al. Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis. J Virol. 2012;86:5314-29 pubmed publisher
    ..here for the first time that EBNA-1 and EBP2 interact in the nucleoplasm, as well as in the nucleoli during interphase. However, in strong contrast to the current proposed model, we were unable to observe any interaction between ..
  50. Kim S, Kim S, Kim S, Rhee K. NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells. J Cell Sci. 2011;124:3760-70 pubmed publisher
    ..Our study revealed that NEK7 activity is required for centrosome cycle progression not only at M phase, but also at G1 phase. ..
  51. Izumi H, Matsumoto Y, Ikeuchi T, Saya H, Kajii T, Matsuura S. BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. Oncogene. 2009;28:2806-20 pubmed publisher
    ..to centrosomes, physically interacts with Plk1 and inhibits Plk1 phosphorylation and its kinase activity during interphase. These results unravel a crucial role of BubR1 in preventing centrosome reduplication through negative ..
  52. Belmont A, Hu Y, Sinclair P, Wu W, Bian Q, Kireev I. Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions. Cold Spring Harb Symp Quant Biol. 2010;75:453-60 pubmed publisher
    How chromatin folds into mitotic and interphase chromosomes has remained a difficult question for many years...
  53. Teixido Travesa N, Villen J, Lacasa C, Bertran M, Archinti M, Gygi S, et al. The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. Mol Biol Cell. 2010;21:3963-72 pubmed publisher
    ..We also identified GCP8/MOZART2 as a novel core subunit that is present in both interphase and mitotic ?TuRCs...