extramedullary hematopoiesis

Summary

Summary: The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.

Top Publications

  1. Coyne J. Extramedullary haemopoiesis. J Clin Pathol. 2005;58:448 pubmed
  2. Sauer B, Buy X, Gangi A, Roy C. Exceptional localization of extramedullary hematopoiesis: presacral and periureteral masses. Acta Radiol. 2007;48:246-8 pubmed
    We report an exceptional case of periureteral and presacral localizations of extramedullary hematopoiesis. To our knowledge, the association of presacral or periureteral masses has not been described before...
  3. Mimura R, Kamishima T, Kubota K, Nakano F, Yabe I, Sasaki H, et al. Extramedullary plasmacytoma involving perirenal space accompanied by extramedullary hematopoiesis and amyloid deposition. Jpn J Radiol. 2010;28:309-13 pubmed publisher
    ..Pathological diagnosis of the biopsy specimen was extramedullary plasmacytoma accompanied by extramedullary hematopoiesis and amyloid deposition...
  4. Brennan L, Mayer T, Devitt J. Extramedullary hematopoiesis occurring as a nasal polyp in a man with a myeloproliferative disorder. Ear Nose Throat J. 2004;83:258-9 pubmed
    ..The mass was resected and proved to represent a focus of extramedullary hematopoiesis. The patient subsequently developed extramedullary hematopoiesis of the skin and the stomach wall...
  5. Al Marzooq Y, Al Bahrani A, Chopra R, Al Momatten M. Fine-needle aspiration biopsy diagnosis of intrathoracic extramedullary hematopoiesis presenting as a posterior mediastinal tumor in a patient with sickle-cell disease: Case report. Diagn Cytopathol. 2004;30:119-21 pubmed
    b>Extramedullary hematopoiesis (EMH) is a rare cause of an intrathoracic mass. Fine-needle aspiration biopsy (FNAB) has been only occasionally documented as a useful tool in diagnosing EMH tumor...
  6. Gupta P, Eshaghi N, Ghole V, Ketkar M, Garcia Morales F. Presacral extramedullary hematopoiesis: report of a case and review of the literature. Clin Imaging. 2008;32:487-9 pubmed publisher
    b>Extramedullary hematopoiesis is manifested by several clinical hematological disorders. Its localization to presacral space as mass is extremely rare. We report one such case in a patient with hereditary spherocytosis...
  7. Hiradfar M, Zabolinejad N, Zabolinejadm N, Banihashem A, Kajbafzadeh A. Renal splenic heterotopia with extramedullary hematopoiesis in a thalassemic patient, simulating renal neoplasm: a case report. J Pediatr Hematol Oncol. 2007;29:195-7 pubmed
    ..Simultaneous existence of splenorenal heterotopia and extramedullary hematopoiesis in a same patient can present as a mass of kidney...
  8. Horwood E, Dowson H, Gupta R, Kaczmarski R, Williamson M. Myelofibrosis presenting as spinal cord compression. J Clin Pathol. 2003;56:154-6 pubmed
    ..This report describes a case of myelofibrosis presenting as spinal cord compression on account of extramedullary haemopoietic tissue encroaching upon the spinal cord from a large pelvic mass. ..
  9. Policarpio Nicolas M, Bregman S, Ihsan M, Atkins K. Mass-forming extramedullary hematopoiesis diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 2006;34:807-11 pubmed
    b>Extramedullary hematopoiesis (EMH) is usually a microscopic finding. However, it may present as a mass-forming lesion making it amenable to fine-needle aspiration biopsy (FNAB)...

More Information

Publications62

  1. Goerner M, Gerull S, Schaefer E, Just M, Sure M, Hirnle P. Painful spinal cord compression as a complication of extramedullary hematopoiesis associated with beta-thalassemia intermedia. Strahlenther Onkol. 2008;184:224-6 pubmed publisher
    Spinal cord compression due to extramedullary hematopoiesis (EMH) is a rare manifestation of thalassemia. General therapeutic recommendations do not exist...
  2. Bolaman Z, Polatli M, Cildag O, Kadikoylu G, Culhaci N. Intrathoracic extramedullary hematopoiesis resembling posterior mediastinal tumor. Am J Med. 2002;112:739-41 pubmed
  3. Dagdas S, Ozet G, Alanoglu G, Ayli M, Gokmen Akoz A, Erekul S. Unusual extramedullary hematopoiesis in a patient receiving granulocyte colony-stimulating factor. Acta Haematol. 2006;116:198-202 pubmed
    ..fibrosis that developed bilaterally, cervical lymphadenopathy and cutaneous infiltration by trilineage extramedullary hematopoiesis after granulocyte colony-stimulating factor therapy because of severe neutropenia...
  4. Xiros N, Economopoulos T, Papageorgiou E, Mantzios G, Raptis S. Massive hemothorax due to intrathoracic extramedullary hematopoiesis in a patient with hereditary spherocytosis. Ann Hematol. 2001;80:38-40 pubmed
    b>Extramedullary hematopoiesis (EMH) is a rare disorder, characterized by the appearance of hematopoietic elements outside of the bone marrow, which occurs in patients with chronic myeloproliferative disorders or congenital hemolytic ..
  5. Granjo E, Bauerle R, Sampaio R, Manata P, Torres N, Quintanilha A. Extramedullary hematopoiesis in hereditary spherocytosis deficient in ankyrin: a case report. Int J Hematol. 2002;76:153-6 pubmed
    Hereditary spherocytosis (HS) is a common inherited hemolytic anemia due to red cell membrane defects. Extramedullary hematopoiesis is a compensatory response to insufficient bone marrow blood cell production...
  6. Gupta P, Naran A, Auh Y, Chung J. Focal intrahepatic extramedullary hematopoiesis presenting as fatty lesions. AJR Am J Roentgenol. 2004;182:1031-2 pubmed
  7. Niggemann P, Krings T, Hans F, Thron A. Fifteen-year follow-up of a patient with beta thalassaemia and extramedullary haematopoietic tissue compressing the spinal cord. Neuroradiology. 2005;47:263-6 pubmed
    ..A relapse had to be treated again by surgical means combined with postinterventional radiation therapy. A complete relief of the symptoms and control of the lesion could be obtained. ..
  8. Beckner M, Lee J, Schochet S, Chu C. Intracranial extramedullary hematopoiesis associated with pilocytic astrocytoma: a case report. Acta Neuropathol. 2003;106:584-7 pubmed
    ..Intracranial extramedullary hematopoiesis (EMH) is described in a 29-year-old man with a recurrent pilocytic astrocytoma in the tectal region...
  9. Chehal A, Aoun E, Koussa S, Skoury H, Koussa S, Taher A. Hypertransfusion: a successful method of treatment in thalassemia intermedia patients with spinal cord compression secondary to extramedullary hematopoiesis. Spine (Phila Pa 1976). 2003;28:E245-9 pubmed
    b>Extramedullary hematopoiesis is a common compensatory phenomenon to chronic hemolytic anemias including thalassemia. Several sites can be involved including the liver, the spleen, the lymph nodes, and other less common locations...
  10. Du E, Overstreet K, Zhou W, Baird G, Baird S, Bouvet M, et al. Fine needle aspiration of splenic extramedullary hematopoiesis presenting as a solitary mass. A case report. Acta Cytol. 2002;46:1138-42 pubmed
    b>Extramedullary hematopoiesis (EMH) generally occurs in patients with deficient bone marrow hematopoiesis secondary to either peripheral red cell destruction or marrow replacement...
  11. Bizzoni A, Lombardi D, Maroldi R, Incardona P, Nicolai P. Extramedullary hematopoiesis: a rare occurrence in the sinonasal tract. Auris Nasus Larynx. 2010;37:233-7 pubmed publisher
    b>Extramedullary hematopoiesis (EMH) is a systemic reaction to inadequate hematopoiesis. We report two exceedingly rare cases of EMH involving the paranasal sinuses...
  12. Martínez Rodrigo M, Sanjuanbenito L, Rodríguez del Barrio E, Martinez San Millan J, Saldana D. [Spinal cord compression secondary to epidural extramedullary hematopoiesis in thalassemia: a clinical case and review of literature]. Rev Neurol. 1998;27:998-1004 pubmed
    b>Extramedullary hematopoiesis generally occurs in a variety of hematological disorders where the normal functioning of the blood forming organs is disturbed...
  13. Schwarz C, Bittner R, Kirsch A, Loddenkemper C, Mairinger T, Schonfeld N, et al. A 62-year-old woman with bilateral pleural effusions and pulmonary infiltrates caused by extramedullary hematopoiesis. Respiration. 2009;78:110-3 pubmed publisher
    ..Biopsies taken from the chest wall pleura revealed extramedullary hematopoiesis (EMH) with abnormal megakaryocytes as well as myeloid and erythroid precursors...
  14. Salanitri G, Hennessy O. Osteopetrosis with intrathoracic extramedullary hematopoiesis. AJR Am J Roentgenol. 2005;184:702-3 pubmed
  15. Castelli R, Graziadei G, Karimi M, Cappellini M. Intrathoracic masses due to extramedullary hematopoiesis. Am J Med Sci. 2004;328:299-303 pubmed
    b>Extramedullary hematopoiesis often occurs in hemoglobinopathies, hemolytic anemias, leukemias, lymphomas, and myeloproliferative disorders. Liver, spleen, and lymph nodes are frequently involved...
  16. Sarmiento J, Wolff B. A different type of presacral tumor: extramedullary hematopoiesis: report of a case. Dis Colon Rectum. 2003;46:683-5 pubmed
  17. Youngster I, Weiss M, Drobot A, Eitan A. An unusual presacral mass: extramedullary hematopoiesis. J Gastrointest Surg. 2006;10:927-9 pubmed
    ..We present an unusual case of a symptomatic presacral mass caused by extramedullary hematopoietic tissue in a thalassemic patient and review the unique aspects of this entity. ..
  18. Valeri R, Ibrahim N, Sheaff M. Extramedullary hematopoiesis in the endometrium. Int J Gynecol Pathol. 2002;21:178-81 pubmed
    b>Extramedullary hematopoiesis (EMH) in the endometrium is an extremely rare occurrence. Four of the eight previously reported cases were related to an underlying hematological disorder, although the remainder had no such relationship...
  19. Jelali M, Luciani A, Kobeiter H, Zafrani S, Anglade M, Zegai B, et al. MRI features of intrahepatic extramedullary haematopoiesis in sickle cell anaemia. Cancer Imaging. 2006;6:182-5 pubmed
  20. Hsieh P, Olsen R, O Malley D, Konoplev S, Hussong J, Dunphy C, et al. The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disorders. Mod Pathol. 2007;20:929-35 pubmed
    b>Extramedullary hematopoiesis (EMH) in the spleen is a characteristic feature of the chronic myeloproliferative disorders (CMPDs) and various other neoplastic or reactive myeloid conditions...
  21. Wang J, Darvishian F. Extramedullary hematopoiesis in breast after neoadjuvant chemotherapy for breast carcinoma. Ann Clin Lab Sci. 2006;36:475-8 pubmed
    We report incidental extramedullary hematopoiesis (EMH) in breasts of 2 patients following neoadjuvant chemotherapy for locally advanced breast cancer. Neither of the patients had a history of hematologic disorders...
  22. Salehi S, Koski T, Ondra S. Spinal cord compression in beta-thalassemia: case report and review of the literature. Spinal Cord. 2004;42:117-23 pubmed
    ..Patient underwent decompressive laminectomy with good surgical outcome. Rapid diagnosis and treatment of such a condition is essential to optimize the chances of recovery. ..
  23. Miyake H, Matsuda M, Iyomasa S, Mizuno K. Presacral extramedullary hematopoiesis. Surgery. 2004;135:112-3 pubmed
  24. Wang Y, Meng Q, Qiao H, Jiang H, Sun X. Role of the spleen in cyclophosphamide-induced hematosuppression and extramedullary hematopoiesis in mice. Arch Med Res. 2009;40:249-55 pubmed publisher
    b>Extramedullary hematopoiesis (EMH) is induced in spleens due to various diseases. The aim of this study is to investigate the role of spleen in cyclophosphamide (CTX)-induced hematosuppression and EMH in mice...
  25. Kugai T, Chibana M. [Left atrial myxoma with extramedullary hematopoiesis and ossification]. Kyobu Geka. 2002;55:376-8 pubmed
    ..The tumor showed the extensive extramedullary hematopoiesis and ossification around scanty clusters of myxoma cells on light microscopy...
  26. Kwon J, Kim D, Minai Tehrani A, Hwang S, Chang S, Lee E, et al. Inhaled fluorescent magnetic nanoparticles induced extramedullary hematopoiesis in the spleen of mice. J Occup Health. 2009;51:423-31 pubmed
    ..The FMNPs induced extramedullary hematopoiesis in the spleen without having a pulmonary effect...
  27. Moncef B, Hafedh J. Management of spinal cord compression caused by extramedullary hematopoiesis in beta-thalassemia. Intern Med. 2008;47:1125-8 pubmed
    Thalassemia is a chronic hemolytic anemia, endemic around the Mediterranean basin. Extramedullary hematopoiesis (EMH) is a normal compensatory reaction that can involve many organs or tissues, including the epidural space, leading to a ..
  28. Goh D, Lee S, Cho D, Park S, Hwang J, Sung J. Chronic idiopathic myelofibrosis presenting as cauda equina compression due to extramedullary hematopoiesis: a case report. J Korean Med Sci. 2007;22:1090-3 pubmed
    b>Extramedullary hematopoiesis (EMH) is occasionally reported in idiopathic myelofibrosis and is generally found in the liver, spleen, and lymph nodes several years after diagnosis...
  29. Miyata T, Masuzawa M, Katsuoka K, Higashihara M. Cutaneous extramedullary hematopoiesis in a patient with idiopathic myelofibrosis. J Dermatol. 2008;35:456-61 pubmed publisher
    Idiopathic myelofibrosis (IM) is a chronic myeloproliferative disorder and some cases of IM have extramedullary hematopoiesis. Extramedullary hematopoiesis is commonly seen in the liver, spleen and lymph nodes, but cutaneous ..
  30. Marchiori E, Escuissato D, Irion K, Zanetti G, Rodrigues R, Meirelles G, et al. Extramedullary hematopoiesis: findings on computed tomography scans of the chest in 6 patients. J Bras Pneumol. 2008;34:812-6 pubmed
    To present findings on computed tomography scans of the chest indicative of extramedullary hematopoiesis in six patients...
  31. Ileri T, Azik F, Ertem M, Uysal Z, Gozdasoglu S. Extramedullary hematopoiesis with spinal cord compression in a child with thalassemia intermedia. J Pediatr Hematol Oncol. 2009;31:681-3 pubmed publisher
    Spinal cord compression due to extramedullary hematopoiesis is an extremely rare complication of thalassemia intermedia...
  32. Gru A, Hassan A, Pfeifer J, Huettner P. Uterine extramedullary hematopoiesis: what is the clinical significance?. Int J Gynecol Pathol. 2010;29:366-73 pubmed publisher
    b>Extramedullary hematopoiesis (EMH) represents abnormal development and growth of hematopoietic tissue outside the bone marrow...
  33. Sharara L, Andersson A, Guy Grand D, Fischer A, DiSanto J. Deregulated TCR alpha beta T cell population provokes extramedullary hematopoiesis in mice deficient in the common gamma chain. Eur J Immunol. 1997;27:990-8 pubmed
  34. Aessopos A, Tassiopoulos S, Farmakis D, Moyssakis I, Kati M, Polonifi K, et al. Extramedullary hematopoiesis-related pleural effusion: the case of beta-thalassemia. Ann Thorac Surg. 2006;81:2037-43 pubmed
    ..Bone deformities, extramedullary hematopoiesis (EMH), and spleen and liver enlargement are the consequences of hypoxia and enhanced erythropoiesis...
  35. Lowell C, Niwa M, Soriano P, Varmus H. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996;87:1780-92 pubmed
    ..birth; surviving animals develop a severe form of osteopetrosis, resulting in extreme levels of splenic extramedullary hematopoiesis, anemia, and leukopenia...
  36. Ohta Y, Shichinohe H, Nagashima K. Spinal cord compression due to extramedullary hematopoiesis associated with polycythemia vera--case report. Neurol Med Chir (Tokyo). 2002;42:40-3 pubmed
    ..Serial MR imaging showed no regrowth of the other epidural masses. Extramedullary hematopoiesis occurs in patients with various hematologic disorders involving a chronic increase in the production of ..
  37. Koch C, Li C, Mesa R, Tefferi A. Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 2003;78:1223-33 pubmed
    ..associated clinical conditions, pathology, natural history, and treatment outcome of nonhepatosplenic extramedullary hematopoiesis (NHS-EMH)...
  38. La Fianza A, Torretta L, Spinazzola A. Extramedullary hematopoiesis in chronic myelofibrosis encasing the pelvicaliceal system and perirenal spaces: CT findings. Urol Int. 2005;75:281-4 pubmed
    ..Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)...
  39. Choi H, David C, Katz R, Podoloff D. Case 69: extramedullary hematopoiesis. Radiology. 2004;231:52-6 pubmed
  40. Vega Harring S, Niyaz M, Okada S, Kudo M. Extramedullary hematopoiesis in a pyogenic granuloma: a case report and review. J Cutan Pathol. 2004;31:555-7 pubmed
    b>Extramedullary hematopoiesis in the adult life is usually associated with hematological disorders...
  41. Bowling M, Cauthen C, Perry C, Patel N, Bergman S, Link K, et al. Pulmonary extramedullary hematopoiesis. J Thorac Imaging. 2008;23:138-41 pubmed publisher
    b>Extramedullary hematopoiesis (EMH) is the formation and development of blood cells outside of the bone marrow. Of particular interest to chest physicians and radiologists is the occurrence of EMH in the lungs and pleura...
  42. Haidar S, Ortiz Neira C, Shroff M, Gilday D, Blaser S. Intracranial involvement in extramedullary hematopoiesis: case report and review of the literature. Pediatr Radiol. 2005;35:630-4 pubmed
    Intracranial involvement in extramedullary hematopoiesis (EMH) is rare, but it should be suspected in patients with myelofibrosis presenting with chronic severe headache...
  43. Lee C, Salzman K, Blumenthal D, Gaffney D. Intracranial extramedullary hematopoiesis: brief review of response to radiation therapy. Am J Hematol. 2005;78:151-2 pubmed
    Intracranial deposits of extramedullary hematopoiesis are extremely rare, and limited experience with the treatment of these lesions has been reported...
  44. Mutijima E, Hmissa S, Ziadi S, Mlaiki A, Mokni M, Korbi S. [Cord compression secondary to extramedullary hematopoiesis in a patient with beta-thalassaemia]. Rev Med Liege. 2005;60:41-4 pubmed
    b>Extramedullary hematopoiesis (EMH) is a common manifestation in beta-thalassemia, but can also occur in several clinical hematologic disorders or neoplasms. It has been reported in almost all sites of the body...
  45. Keikhaei B, Zandian K, Rahim F. Existence of cord compression in extramedullary hematopoiesis due to beta thalassemia intermedia. Hematology. 2008;13:183-6 pubmed publisher
    b>Extramedullary hematopoiesis (EMH) is a rare disorder, characterized by the appearance of hematopoietic elements outside of the bone marrow, which occurs in patients with chronic myeloproliferative disorders or congenital hemolytic ..
  46. Ayyildiz O, Isikdogan A, Celik M, Muftuoglu E. Intracranial meningeal extramedullary hematopoiesis inducing serious headache in a patient with idiopathic myelofibrosis. J Pediatr Hematol Oncol. 2004;26:28-9 pubmed
  47. de Haas K, van de Loosdrecht A, Daenen S. Intraspinal extramedullary haematopoiesis in a patient with myelofibrosis. Neth J Med. 2002;60:256-9 pubmed
  48. Schneider E, Moreau G, Arnould A, Vasseur F, Khodabaccus N, Dy M, et al. Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice. Blood. 1999;94:2613-21 pubmed
    ..These data provide evidence that Fas deficiency can affect hematopoiesis both during adult and fetal life and that these modifications occur independently from other pathologies associated with the lpr phenotype. ..
  49. Schirmacher P, Peters M, Ciliberto G, Blessing M, Lotz J, Meyer zum Buschenfelde K, et al. Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice. Am J Pathol. 1998;153:639-48 pubmed
    ..2) significant acceleration and aggravation of plasmacytoma formation, and 3) excessive activation of extramedullary hematopoiesis in spleen and liver followed by a subsequent increase of all cellular components in the peripheral ..
  50. Al Aabassi A, Murad B. Presacral extramedullary hematopoiesis: a diagnostic confusion concerning a rare presentation. Med Princ Pract. 2005;14:358-62 pubmed
    To report a rare case of extramedullary hematopoiesis (EMH) with an asymptomatic intrapelvic mass in a patient with thalassemia major...
  51. Tamiolakis D, Venizelos I, Lambropoulou M, Efthymiadou A, Arvanitidou V, Tsikouras P, et al. Altered intrahepatic hematopoiesis in neonates from women with pregnancy induced hypertension/pre-eclampsia. Acta Medica (Hradec Kralove). 2004;47:119-23 pubmed
    ..We suggest that these findings reflect a state of persistent inflammation and a loss of red blood cell production possibly contributing to the neonatal morbidity related to this disorder. ..
  52. Au W, Wong K, Leung R, Tong A. Isolated gingival relapse of acute lymphoblastic leukemia after transplantation. J Oral Pathol Med. 2008;37:249-51 pubmed publisher
    ..Examinations of the peripheral blood and marrow were normal. Molecular studies confirmed clonal relationship between the gum lesion with the original marrow disease, despite the anatomical, histological and chronological separations. ..
  53. Vortmeyer A, Frank S, Jeong S, Yuan K, Ikejiri B, Lee Y, et al. Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res. 2003;63:7051-5 pubmed
    ..The angioblasts are capable of differentiating into RBCs via formation of blood islands with extramedullary hematopoiesis. Because of VHL deficiency, Epo receptor-expressing, developmentally arrested angioblasts ..