cell plasticity


Summary: The ability of a cell to change its PHENOTYPE in response to changes in the environment.

Top Publications

  1. Krebs A, Mitschke J, Lasierra Losada M, Schmalhofer O, Boerries M, Busch H, et al. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol. 2017;19:518-529 pubmed publisher
    ..Therapeutic strategies should consider these potential specificities of EMT-TFs to target these factors simultaneously. ..
  2. Donati G, Rognoni E, Hiratsuka T, Liakath Ali K, Hoste E, Kar G, et al. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties. Nat Cell Biol. 2017;19:603-613 pubmed publisher
    ..This resolves the long-standing debate about the contribution of terminally differentiated cells to epidermal wound repair. ..
  3. Doherty R, Sisley K, Hammond D, Rennie I, Cross N. Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics. Invest Ophthalmol Vis Sci. 2017;58:5387-5395 pubmed publisher
    ..We hypothesize that this capacity to undergo phenotypic plasticity may be a consequence of neural crest lineage and renders the exploration of the CSC hypothesis extremely challenging in UM. ..
  4. Bhat J, Helmuth J, Chitadze G, Kouakanou L, Peters C, Vingron M, et al. Stochastics of Cellular Differentiation Explained by Epigenetics: The Case of T-Cell Differentiation and Functional Plasticity. Scand J Immunol. 2017;86:184-195 pubmed publisher
    ..Therefore, we address the impact of some epigenetic modifiers on T-cell activation and differentiation, and discuss possible synergies with T cell-based immunotherapeutic strategies. ..
  5. Ito I, Asai A, Suzuki S, Kobayashi M, Suzuki F. M2b macrophage polarization accompanied with reduction of long noncoding RNA GAS5. Biochem Biophys Res Commun. 2017;493:170-175 pubmed publisher
    ..These results indicate that the reduction of GAS5 RNA influenced by the NMD pathway activation leads to the M? polarization stimulated with LPS and IC in combination. ..
  6. Murgai M, Ju W, Eason M, Kline J, Beury D, Kaczanowska S, et al. KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. Nat Med. 2017;23:1176-1190 pubmed publisher
    ..Our data revealed a previously unidentified role for perivascular cells in pre-metastatic niche formation and uncovered novel strategies for limiting metastasis. ..
  7. Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, et al. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2017;37:1470-1481 pubmed publisher
    ..Our data suggest that MED1 is required for the PPAR?-mediated M2 phenotype switch, with M2 marker genes induced but M1 marker genes suppressed. MED1 in macrophages has an antiatherosclerotic role via PPAR?-regulated transactivation. ..
  8. Varga J, Greten F. Cell plasticity in epithelial homeostasis and tumorigenesis. Nat Cell Biol. 2017;19:1133-1141 pubmed publisher
    ..Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition-two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer. ..
  9. Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R. HIF-1?/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells. Exp Cell Res. 2017;360:243-256 pubmed publisher
    ..Our results confirmed a novel HIF-1?/Ascl2/miR-200b regulatory feedback circuit in modulating EMT-MET plasticity of CRC cells, which could serve as a possible therapeutic target. ..

More Information


  1. Sahasrabudhe P, Rohrberg J, Biebl M, Rutz D, Buchner J. The Plasticity of the Hsp90 Co-chaperone System. Mol Cell. 2017;67:947-961.e5 pubmed publisher
    ..Interestingly, some co-chaperones affect client conformation in vivo. Thus, co-chaperones adapt the Hsp90 cycle to the requirements of the client proteins, ensuring optimal activation. ..
  2. Martínez Zamudio R, Robinson L, Roux P, Bischof O. SnapShot: Cellular Senescence in Pathophysiology. Cell. 2017;170:1044-1044.e1 pubmed publisher
    ..Cellular senescence is a fundamental cell fate, important both in physiological and pathophysiological processes. This SnapShot focuses on the role of cellular senescence in health, disease, and aging. ..
  3. O Brien Ball C, Biddle A. Reprogramming to developmental plasticity in cancer stem cells. Dev Biol. 2017;430:266-274 pubmed publisher
    ..More research is needed to identify developmental mechanisms that are active in cancer, so that these may be targeted to reduce tumour growth and metastasis and overcome therapeutic resistance. ..
  4. Pennell L, Fish E. Interferon-β regulates dendritic cell activation and migration in experimental autoimmune encephalomyelitis. Immunology. 2017;152:439-450 pubmed publisher
    ..Taken together, our data support immunoregulatory roles for IFN-β in the activation and migration of DCs during EAE. ..
  5. Curi R, de Siqueira Mendes R, de Campos Crispin L, Norata G, Sampaio S, Newsholme P. A past and present overview of macrophage metabolism and functional outcomes. Clin Sci (Lond). 2017;131:1329-1342 pubmed publisher
    ..A past and present overview of macrophage metabolism and impact of endocrine regulation and the relevance to human disease are described in this review. ..
  6. Stockinger B, Omenetti S. The dichotomous nature of T helper 17 cells. Nat Rev Immunol. 2017;17:535-544 pubmed publisher
  7. Hoeck J, Biehs B, Kurtova A, Kljavin N, De Sousa E Melo F, Alicke B, et al. Stem cell plasticity enables hair regeneration following Lgr5+ cell loss. Nat Cell Biol. 2017;19:666-676 pubmed publisher
    ..Thus, our study uncovers a compensatory relationship between two stem cell populations and the underlying molecular mechanisms that enable hair follicle regeneration. ..
  8. Köstlin N, Vogelmann M, Spring B, Schwarz J, Feucht J, Hartel C, et al. Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype. Immunology. 2017;152:89-101 pubmed publisher
    ..These results point towards a role of MDSC in regulating neonatal immune responses. Targeting MDSC function in neonates could be a therapeutic opportunity to improve neonatal host defence. ..
  9. Bhela S, Varanasi S, Jaggi U, Sloan S, Rajasagi N, Rouse B. The Plasticity and Stability of Regulatory T Cells during Viral-Induced Inflammatory Lesions. J Immunol. 2017;199:1342-1352 pubmed publisher
    ..Our results demonstrate that CD25lo Treg and iTreg instability occurs during a viral immunoinflammatory lesion and that its control may help to avoid lesion chronicity. ..
  10. Batlle E, Clevers H. Cancer stem cells revisited. Nat Med. 2017;23:1124-1134 pubmed publisher
    ..Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging...
  11. Wang K, Melki R, Kabani M. A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast. PLoS ONE. 2017;12:e0184905 pubmed publisher
    ..Such an important selective advantage may contribute to the evolutionary conservation of the prion-forming ability of Sup35p orthologues in distantly related yeast species. ..
  12. Micalizzi D, Maheswaran S, Haber D. A conduit to metastasis: circulating tumor cell biology. Genes Dev. 2017;31:1827-1840 pubmed publisher
    ..Additionally, the study of CTCs has exposed dramatic intrapatient and interpatient heterogeneity and their evolution over time. In this review, we focus on the current knowledge of CTC biology and the potential clinical implications. ..
  13. Krasovec R, Richards H, Gifford D, Hatcher C, Faulkner K, Belavkin R, et al. Spontaneous mutation rate is a plastic trait associated with population density across domains of life. PLoS Biol. 2017;15:e2002731 pubmed publisher
    ..Such a prevalent environmental association and conserved mechanism suggest that mutation has varied plastically with population density since the early origins of life. ..
  14. Shanshiashvili L, Tsitsilashvili E, Dabrundashvili N, Kalandadze I, Mikeladze D. Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. Biol Res. 2017;50:4 pubmed publisher
    ..We propose that elevation of intracellular glutamate and expression of mGluR5 may initiate the metabolic rearrangement in macrophages that could contribute to the formation of an immunosuppressive phenotype. ..
  15. Altieri D. Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis. Br J Cancer. 2017;117:301-305 pubmed publisher
    ..Some of these pathways are druggable, opening fresh therapeutic opportunities for advanced and disseminated disease. ..
  16. Li Y, Ma D, Wang Z, Yang J. MicroRNA-155 Deficiency in Kupffer Cells Ameliorates Liver Ischemia-Reperfusion Injury in Mice. Transplantation. 2017;101:1600-1608 pubmed publisher
    ..miR-155 deficiency plays an effective role in attenuating liver IR injury likely by regulating the activation and inflammatory response, as well as modifying the polarization of KCs. ..
  17. Rickman D, Beltran H, Demichelis F, Rubin M. Biology and evolution of poorly differentiated neuroendocrine tumors. Nat Med. 2017;23:1-10 pubmed publisher
    ..We discuss the shared genomic alterations of these tumors independently of their site of origin, and we explore potential therapeutic strategies on the basis of recent biological findings. ..
  18. Takahashi R, Nakatsukasa H, Shiozawa S, Yoshimura A. SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions. J Immunol. 2017;199:149-158 pubmed publisher
    ..The results indicate that Socs1-deficient Tregs tend to convert into ex-Tregs under the inflammatory conditions in which APCs are highly activated, and that SOCS1 could be a useful target for enhancement of anti-tumor immunity. ..
  19. Petruk S, Cai J, Sussman R, Sun G, Kovermann S, Mariani S, et al. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation. Mol Cell. 2017;66:247-257.e5 pubmed publisher
    ..This insight may explain the developmental plasticity of stem cells and facilitate their exploitation for therapeutic purposes. ..