cell cycle checkpoints


Summary: Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.

Top Publications

  1. Boons E, Vanstreels E, Jacquemyn M, Nogueira T, Neggers J, Vercruysse T, et al. Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma. EBioMedicine. 2015;2:1102-13 pubmed publisher
  2. Dozier C, Mazzolini L, Cénac C, Froment C, Burlet Schiltz O, Besson A, et al. CyclinD-CDK4/6 complexes phosphorylate CDC25A and regulate its stability. Oncogene. 2017;36:3781-3788 pubmed publisher
    ..Thus our results identify cyclinD-CDK4/6 complexes as novel regulators of CDC25A stability during G1 phase, generating a negative feedback loop allowing control of the G1/S transition. ..
  3. Han D, Byun S, Kim J, Kwon M, Pleasure S, Ahn J, et al. Human Cytomegalovirus IE2 Protein Disturbs Brain Development by the Dysregulation of Neural Stem Cell Maintenance and the Polarization of Migrating Neurons. J Virol. 2017;91: pubmed publisher
    ..Our data suggest that the wide spectrum of clinical outcomes, ranging from mental retardation to microcephaly, caused by congenital HCMV infection can be sufficiently explained in terms of IE2 action alone. ..
  4. Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, et al. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J Biol Chem. 2017;292:17658-17667 pubmed publisher
    ..This work is the first structural study of MAD2L2 aside from its role in TLS and might pave the way to clarify MAD2L2's function in mitosis. ..
  5. Qi Z, Cai J, Chen L, Yue Q, Gong Y, Yao Y, et al. TRIM28 as an independent prognostic marker plays critical roles in glioma progression. J Neurooncol. 2016;126:19-26 pubmed
    ..In a xenograft model, down-regulating TRIM28 suppressed tumor growth. These results indicate that over-expression of TRIM28 is associated with poor outcome in glioma patients. ..
  6. Qi J, Deng J, Qian K, Tian L, Li J, He K, et al. Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle. Eur J Med Chem. 2017;134:34-42 pubmed publisher
    ..Caspase activation was somewhat mediated by the release of Cyt C from mitochondria after incubation with selected agents. Both types of Ga(III) complexes showed more effective in inhibition of the G1/S transition than the ligand alone. ..
  7. Pawlik A, Wała M, Hać A, Felczykowska A, Herman Antosiewicz A. Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells. Phytomedicine. 2017;29:1-10 pubmed publisher
    ..SF exhibits cytotoxic activity against breast cancer cells even at relatively low concentrations (5-10µM). This is associated with induction of the cell cycle arrest and apoptosis. SF might be considered as a potent anticancer agent. ..
  8. Overstreet J, Wang Y, Wang X, Niu A, Gewin L, Yao B, et al. Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis. FASEB J. 2017;31:4407-4421 pubmed publisher
    ..Overstreet, J. M., Wang, Y., Wang, X., Niu, A., Gewin, L. S., Yao, B., Harris, R. C., Zhang, M.-Z. Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis. ..
  9. Geng Y, Zhang C, Lei J, Yu P, Xia Y, Zhang H, et al. Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer. Biochem Pharmacol. 2017;142:71-86 pubmed publisher
    ..In summary, our findings demonstrated that walsuronoid B caused G2/M phase arrest and induced mitochondrial and lysosomal apoptosis through the ROS/p53 signaling pathway in human liver cancer cells in vitro and in vivo. ..

More Information

Publications111 found, 100 shown here

  1. Watanabe Y, Nakajima K, Mizukami S, Akahori Y, Imatanaka N, Woo G, et al. Differential effects between developmental and postpubertal exposure to N-methyl-N-nitrosourea on progenitor cell proliferation of rat hippocampal neurogenesis in relation to COX2 expression in granule cells. Toxicology. 2017;389:55-66 pubmed publisher
    ..Thus, the disrupted pattern of hippocampal neurogenesis induced by MNU is different between developmental and postpubertal exposure. ..
  2. Zhang J, Jiang Y, Zhao Y, Wang W, Xie Y, Wang H, et al. Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma. Tumour Biol. 2017;39:1010428317712444 pubmed publisher
    ..Our study demonstrates that tyrosine threonine kinase can be a potential therapeutic target for endometrial endometrioid carcinoma treatment. ..
  3. Wang R, Sunchu B, Perez V. Rapamycin and the inhibition of the secretory phenotype. Exp Gerontol. 2017;94:89-92 pubmed publisher
    ..We have found that rapamycin activates the Nrf2 pathway to regulate cell cycle arrest, but not the production of SASP, which is regulated by a different pathway, probably involving the inhibition of MAPKAPK2. ..
  4. Li W, Zhang H, Nie M, Tian Y, Chen X, Chen C, et al. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. Acta Biochim Biophys Sin (Shanghai). 2017;49:367-373 pubmed publisher
    ..In conclusion, our results suggest that the UA derivative FZU-03,010 is more potent in inhibiting cancer cell survival, and FZU-03,010 has the potential to be developed as a therapeutic for renal cell cancers and TNBCs. ..
  5. Liu Z, He K, Ma Q, Yu Q, Liu C, Ndege I, et al. Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer. PLoS ONE. 2017;12:e0177694 pubmed publisher
    ..These results demonstrated that targeting autophagy should be considered as an effective therapeutic strategy to enhance the sensitivity of EGFR inhibitors on TNBC. ..
  6. Gupta A, Singh V, Kumar D, Yadav P, Kumar S, Beg M, et al. Curcumin-3,4-Dichloro Phenyl Pyrazole (CDPP) overcomes curcumin's low bioavailability, inhibits adipogenesis and ameliorates dyslipidemia by activating reverse cholesterol transport. Metabolism. 2017;73:109-124 pubmed publisher
    ..CDPP could be used as a potential drug candidate against adipogenesis and dyslipidemia with enhanced gastrointestinal stability and bioavailability. ..
  7. Ma X, Li L, Jia T, Chen M, Liu G, Li C, et al. miR-203a controls keratinocyte proliferation and differentiation via targeting the stemness-associated factor ?Np63 and establishing a regulatory circuit with SNAI2. Biochem Biophys Res Commun. 2017;491:241-249 pubmed publisher
    ..Our data highlights a coherent cross-talk between two transcription factors (SNAI2 and ?Np63) and miR-203a in keratinocyte differentiation and epidermal development. ..
  8. Zheng X, Xu W, Sun R, Yin H, Dong C, Zeng H. Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells. Chem Biol Interact. 2017;275:74-85 pubmed publisher
    ..In short, BBSKE synergizes selenite in inhibiting proliferation and inducing death of NSCLC cells; BBSKE combined with selenite may be a treatment strategy for NSCLC. ..
  9. Daaboul H, Daher C, Bodman Smith K, Taleb R, Shebaby W, Boulos J, et al. Antitumor activity of ?-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. Chem Biol Interact. 2017;275:162-170 pubmed publisher
    ..HC treatment also had antitumor effect in vivo with no significant toxicity to laboratory mice. ..
  10. Kashani K, Al Khafaji A, Ardiles T, Artigas A, Bagshaw S, Bell M, et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013;17:R25 pubmed publisher
    ..Both markers are superior to existing markers, provide additional information over clinical variables and add mechanistic insight into AKI. ClinicalTrials.gov number NCT01209169. ..
  11. Moriggi G, Gaspar S, Nieto B, Bustelo X, Dosil M. Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast. RNA. 2017;23:1432-1443 pubmed publisher
    ..We propose that this might be a strategy to expedite the delivery of ribosomes to the growing bud...
  12. Janaki Ramaiah M, Naushad S, Lavanya A, Srinivas C, Anjana Devi T, Sampathkumar S, et al. Scriptaid cause histone deacetylase inhibition and cell cycle arrest in HeLa cancer cells: A study on structural and functional aspects. Gene. 2017;627:379-386 pubmed publisher
    ..This observation was further strengthened by an artificial neuronal network (ANN) model. ..
  13. Mahaddalkar T, Mehta S, Cheriyamundath S, Muthurajan H, Lopus M. Tryptone-stabilized gold nanoparticles target tubulin and inhibit cell viability by inducing an unusual form of cell cycle arrest. Exp Cell Res. 2017;360:163-170 pubmed publisher
    ..Our data indicate that TsAuNPs inhibit cell viability by inducing differential cell cycle arrest possibly through disrupted dynamicity of cellular microtubules. ..
  14. Lu C, Meng S, Jin Y, Zhang W, Li Z, Wang F, et al. A novel multi-epitope vaccine from MMSA-1 and DKK1 for multiple myeloma immunotherapy. Br J Haematol. 2017;178:413-426 pubmed publisher
    ..This study identified a novel peptide from MMSA-1 and the multi-epitope vaccine will be used to establish appropriate individualized therapy for MM. ..
  15. Czink E, Kloor M, Goeppert B, Fröhling S, Uhrig S, Weber T, et al. Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer. Cold Spring Harb Mol Case Stud. 2017;3: pubmed publisher
    ..Further studies are required to determine the value of these markers for predicting the success of immune checkpoint blockade. ..
  16. Heppt M, Steeb T, Schlager J, Rosumeck S, Dressler C, Ruzicka T, et al. Immune checkpoint blockade for unresectable or metastatic uveal melanoma: A systematic review. Cancer Treat Rev. 2017;60:44-52 pubmed publisher
    ..9months. UM is little responsive to ipilimumab regardless of dosage schemes. Sound randomized clinical trials are needed to evaluate the efficacy of combined ICB in patients with UM. ..
  17. Rubiolo J, López Alonso H, Martinez P, Millan A, Cagide E, Vieytes M, et al. Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3. Cell Signal. 2014;26:419-32 pubmed
    ..The involvement of mTOR and BNIP3 in the autophagy induction was also determined. ..
  18. Dong X, Fu J, Yin X, Qu C, Yang C, He H, et al. Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway. Cell Physiol Biochem. 2017;42:685-696 pubmed publisher
    ..These findings underscore the need for risk assessment of human exposure to aloe-emodin. ..
  19. Yoshida K, Toden S, Ravindranathan P, Han H, Goel A. Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression. Carcinogenesis. 2017;38:1036-1046 pubmed publisher
    ..Overall, this study indicates clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC...
  20. Su L, Xin H, Liu Y, Zhang J, Xin H, Su X. Anticancer bioactive peptide (ACBP) inhibits gastric cancer cells by upregulating growth arrest and DNA damage-inducible gene 45A (GADD45A). Tumour Biol. 2014;35:10051-6 pubmed
    ..Our findings have significant implications on the molecular mechanism understanding, biomarker development, and anticancer drug development of ACBP. ..
  21. Shaik S, Vishnuvardhan M, Sultana F, Subba Rao A, Bagul C, Bhattacharjee D, et al. Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors. Bioorg Med Chem. 2017;25:3285-3297 pubmed publisher
    ..Molecular docking studies indicated that these conjugates occupy the colchicine binding site of the tubulin protein. ..
  22. Sun X, Zhao P, Jin S, Liu M, Wang X, Huang Y, et al. Shedding lights on the flexible-armed porphyrins: Human telomeric G4 DNA interaction and cell photocytotoxicity research. J Photochem Photobiol B. 2017;173:606-617 pubmed publisher
    ..It is found that the porphyrins with positive charges located at the end of the flexible arms represent an exciting opportunity for photochemotherapeutic anti-cancer drug design. ..
  23. De Simone V, Bevivino G, Sedda S, Izzo R, Laudisi F, Dinallo V, et al. Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death. Cell Death Dis. 2017;8:e2681 pubmed publisher
    ..These findings delineate a novel mechanism by which Smad7 knockdown promotes CRC cell death. ..
  24. Qiao Y, Li Q, Du H, Wang Q, Huang Y, Liu W. Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor. Biochem Biophys Res Commun. 2017;488:445-452 pubmed publisher
    ..Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application. ..
  25. Liu H, Chen A, Yin Q, Li Z, Huang S, Du G, et al. New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription. J Med Chem. 2017;60:5438-5454 pubmed publisher
    ..7a4 could inhibit Burkitt's lymphoma cell proliferation through cell cycle arrest and apoptosis and suppress tumor growth in a human Burkitt's lymphoma xenograft. ..
  26. Shi R, Yu X, Wang Y, Sun J, Sun Q, Xia W, et al. Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer. Tumour Biol. 2017;39:1010428317695928 pubmed publisher
  27. Wang Y, Chen S, Karnezis A, Colborne S, Santos N, Lang J, et al. The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type. J Pathol. 2017;242:371-383 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  28. Luo H, Liang H, Chen J, Xu Y, Chen Y, Xu L, et al. Hydroquinone induces TK6 cell growth arrest and apoptosis through PARP-1/p53 regulatory pathway. Environ Toxicol. 2017;32:2163-2171 pubmed publisher
    ..The reduction of PARP-1 expression further intensified up-regulation of p53 in TK6-shPARP-1 cells, resulting in an increased G1?S phase cell arrest and apoptosis in TK6-shPARP-1 cells compared to TK6-shNC cells. ..
  29. Wang H, Yu X, Fan Y. [Prospect and Current Situation of Immune Checkpoint Inhibitors ?in First-line Treatment in Advanced Non-small Cell Lung Cancer Patients]. Zhongguo Fei Ai Za Zhi. 2017;20:427-432 pubmed publisher
    ..1???programmed death-1, PD-1??????PD-L1??????????????????non-small cell lung cancer, NSCLC??????????????????????NSCLC????????????????????????????????????????????????????????III????????????????????????????NSCLC????????????????. ..
  30. Shen F, Wang Z, Wu S, Ren S, Man R, Wang B, et al. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX. Bioorg Med Chem Lett. 2017;27:3653-3660 pubmed publisher
    ..Our study might contribute to COX-2, 5-LOX dual inhibitors thus exploit promising novel cancer prevention agents. ..
  31. Dong Q, Sharma S, Liu H, Chen L, Gu B, Sun X, et al. HDAC inhibitors reverse acquired radio resistance of KYSE-150R esophageal carcinoma cells by modulating Bmi-1 expression. Toxicol Lett. 2014;224:121-9 pubmed
    ..When combined with IR, HDIs inhibited Bmi-1 expression in KYSE-150R cells and their ability to repair DNA damage. The results demonstrate the potential utility of HDIs in augmenting the efficacy of fractionated radiotherapy. ..
  32. Alexiou G, Lazari D, Markopoulos G, Vartholomatos E, Hodaj E, Galani V, et al. Moschamine inhibits proliferation of glioblastoma cells via cell cycle arrest and apoptosis. Tumour Biol. 2017;39:1010428317705744 pubmed publisher
    ..The zebrafish mortality on the fifth post-fertilization day was zero even for 1 mM of moschamine concentration. The treatment of glioblastoma cell lines with moschamine may represent a novel strategy for targeting glioblastoma. ..
  33. Belayachi L, Aceves Luquero C, Merghoub N, de Mattos S, Amzazi S, Villalonga P, et al. INDUCTION OF CELL CYCLE ARREST AND APOPTOSIS BY ORMENIS ERIOLEPIS A MORROCAN ENDEMIC PLANT IN VARIOUS HUMAN CANCER CELL LINES. Afr J Tradit Complement Altern Med. 2017;14:356-373 pubmed publisher
    ..Our data suggest that bioactive compounds present in Ormenis eriolepis show significant anti proliferative activity inducing cell cycle arrest and cell death operating through apoptosis pathway. ..
  34. Yu Y, Katiyar S, Sundar D, Kaul Z, Miyako E, Zhang Z, et al. Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences. Cell Death Dis. 2017;8:e2755 pubmed publisher
    ..The results suggest that Wi-A could be a new candidate drug for ALT cancers. ..
  35. Mu R, Tat J, Zamudio R, Zhang Y, Yates J, Kumagai A, et al. CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Mol Cell Biol. 2017;37: pubmed publisher
    ..Finally, we provide evidence that the role of CKS protein-dependent checkpoint override involves recovery from checkpoint-mediated arrest of DNA replication. ..
  36. Zhang Y, Su X, Kong Z, Fu F, Zhang P, Wang D, et al. An androgen reduced transcript of LncRNA GAS5 promoted prostate cancer proliferation. PLoS ONE. 2017;12:e0182305 pubmed publisher
    ..This study provides novel insights to identify potential diagnostic biomarker and therapy target for prostate cancer in clinical treatment. ..
  37. Wang J, Wang L, Ji Q, Zhu H, Han S. Knockdown of Nucleostemin in an ovarian cancer SKOV-3 cell line and its effects on cell malignancy. Biochem Biophys Res Commun. 2017;487:262-267 pubmed publisher
    ..Furthermore, the knockdown of Nucleostemin dramatically suppressed xenograft progression in BALB/c nude mice. Our findings suggest that Nucleostemin is associated with malignancy in an ovarian cancer SKOV-3 cell line. ..
  38. Li G, Niu H, Zhang Y, Li Y, Xie F, Langford P, et al. Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis. PLoS ONE. 2017;12:e0177199 pubmed publisher
    ..The apoptosis induced by CDT holotoxin was significantly inhibited by pifithrin-?, which indicates that it is p53-dependent. The results suggest that H. parasuis CDT holotoxin is a major virulence factor. ..
  39. Richer A, Cala J, O Brien K, Carson V, INGE L, Whitsett T. WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer. Cancer Res. 2017;77:4663-4672 pubmed publisher
    ..Collectively, these findings provide a clinical application for AZD1775 with DNA-damaging agents in KRAS/LKB1 NSCLC. Cancer Res; 77(17); 4663-72. ©2017 AACR. ..
  40. Li X, Lee M, Chen G, Zhang Q, Zheng S, Wang G, et al. 3-O-Substituted-3',4',5'-trimethoxyflavonols: Synthesis and cell-based evaluation as anti-prostate cancer agents. Bioorg Med Chem. 2017;25:4768-4777 pubmed publisher
    ..Our findings imply that modification on 3-OH of trimethoxyflavonol can further enhance its in vitro anti-proliferative potency and PC-3 cell apoptosis induction. ..
  41. Poulton J, Cuningham J, Peifer M. Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size. J Cell Biol. 2017;216:1255-1265 pubmed publisher
    ..Our data provide novel insights into the mechanisms by which different tissues manage genome stability and parallels with human microcephaly. ..
  42. Kozuki T, Chikamori K, Surleac M, Micluta M, Petrescu A, Norris E, et al. Roles of the C-terminal domains of topoisomerase II? and topoisomerase II? in regulation of the decatenation checkpoint. Nucleic Acids Res. 2017;45:5995-6010 pubmed publisher
    ..Together these results suggest that topo II? and topo II? cooperate to maintain genome stability, which may be distinctly modulated by their CTDs. ..
  43. Feeley K, Adams C, Mitra R, Eischen C. Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. Cancer Res. 2017;77:3823-3833 pubmed publisher
    ..Moreover, our results suggest that p73 compensates for loss of p53 and that targeting Mdm2 in p53-deficient cancers has therapeutic potential. Cancer Res; 77(14); 3823-33. ©2017 AACR. ..
  44. Yu J, Han Q, Cui Y. Decreased long non-coding RNA SPRY4-IT1 contributes to ovarian cancer cell metastasis partly via affecting epithelial-mesenchymal transition. Tumour Biol. 2017;39:1010428317709129 pubmed publisher
  45. Shao G, Lai W, Wan X, Xue J, Wei Y, Jin J, et al. Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation. Oncol Rep. 2017;37:2891-2896 pubmed publisher
    ..These results imply that the EGFR cascade inhibitors in combination with TSA may represent a promising differentiation therapy strategy for ovarian cancer. ..
  46. Su N, Wu S, Chi C, Liu C, Tsai T, Chen Y. Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition. Molecules. 2017;22: pubmed publisher
    ..In conclusion, metronomic cordycepin therapy showed effective tumor control, prolonged survival and low toxicities. Cytotoxicity against cancer cells with apoptotic features and EMT inhibition were observed. ..
  47. Yao C, Carraro G, Konda B, Guan X, Mizuno T, Chiba N, et al. Sin3a regulates epithelial progenitor cell fate during lung development. Development. 2017;144:2618-2628 pubmed publisher
    ..Together, these findings reveal that Sin3a is an essential regulator for early lung endoderm specification and differentiation. ..
  48. Ryu J, Koo H. The Caenorhabditis elegans WRN helicase promotes double-strand DNA break repair by mediating end resection and checkpoint activation. FEBS Lett. 2017;591:2155-2166 pubmed publisher
    ..We conclude that WRN-1 plays a conserved role in the resection of DSB ends and mediates checkpoint signaling, thereby influencing levels of RPA and RAD-51. ..
  49. Zhang R, Liu R, Liu C, Niu Y, Zhang J, Guo B, et al. A Novel Role for MiR-520a-3p in Regulating EGFR Expression in Colorectal Cancer. Cell Physiol Biochem. 2017;42:1559-1574 pubmed publisher
    ..This study highlights a tumour suppressor role for miR-520a-3p in colorectal cancer via the regulation of EGFR expression. Thus, miR-520a-3p may be a novel molecular therapeutic target for colorectal cancer. ..
  50. Sun W, Ji Y, Wan Y, HAN H, Lin H, Lu G, et al. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorg Med Chem Lett. 2017;27:4066-4074 pubmed publisher
    ..Meanwhile, it seems that the effect of C5 on MCF-7 cells apoptosis inducing was observed to be not obvious enough. In addition, docking analysis demonstrated that the congeners occupy the colchicine binding pocket of tubulin. ..
  51. Pang Y, An B, Lou L, Zhang J, Yan J, Huang L, et al. Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. J Med Chem. 2017;60:7300-7314 pubmed publisher
    ..In summary, 11a could serve as a promising lead for the development of highly efficient anticancer agents. ..
  52. Han Y, Kee J, Kim D, Mun J, Park S, Kim Y, et al. Arctii Fructus Inhibits Colorectal Cancer Cell Proliferation and MMPs Mediated Invasion via AMPK. Am J Chin Med. 2017;45:1309-1325 pubmed publisher
    ..Collectively, this study demonstrates that AF inhibits the proliferation and metastatic properties of CRC cells. ..
  53. Xu C, Fang L, Kong Y, Xiao C, Yang M, Du L, et al. Knockdown of RMI1 impairs DNA repair under DNA replication stress. Biochem Biophys Res Commun. 2017;494:158-164 pubmed publisher
    ..These findings reveal the importance of RMI1 in response to replication stress, which could explain the molecular basis for its function in maintaining genome integrity...
  54. Lu W, Cheng F, Yan W, Li X, Yao X, Song W, et al. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017;36:4719-4731 pubmed publisher
    ..Collectively, this study demonstrates that pharmacologic inhibition of CypA offers a potential therapeutic strategy via specific activation of p53-72R in NSCLC. ..
  55. Kobayashi Y, Saito Y, Goto M, Nakagawa Goto K. Antitubulin effects of aminobenzothiophene-substituted triethylated chromones. Bioorg Med Chem Lett. 2017;27:2731-2735 pubmed publisher
    ..Among all compounds, compound 7 scored best pharmaceutically with LogP 2.11 and biologically with greater antiproliferative activity and induction of cell cycle arrest at prometaphase. ..
  56. Jevtic P, Levy D. More Cytoplasm, More Problems. Dev Cell. 2017;41:221-223 pubmed publisher
    ..The authors find that large cytoplasmic volume affects spindle pole morphology, chromosome alignment, and stringency of checkpoint signaling, resulting in error-prone chromosome segregation. ..
  57. Badolato M, Carullo G, Armentano B, Panza S, Malivindi R, Aiello F. Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives. Bioorg Med Chem Lett. 2017;27:3092-3095 pubmed publisher
    ..Cell cycle and western blotting analysis suggested apoptosis as possible mechanism for its anti-proliferative activity. These preliminary results encourage our interest for further optimizations. ..
  58. Medina O Donnell M, Rivas F, Reyes Zurita F, Martinez A, Galisteo González F, Lupiáñez J, et al. Synthesis and in vitro antiproliferative evaluation of PEGylated triterpene acids. Fitoterapia. 2017;120:25-40 pubmed publisher
    ..Finally, we have also studied changes in mitochondrial membrane potential during apoptosis of HT29 cancer cells, and the results suggest an activation of the extrinsic apoptotic pathway for these compounds. ..
  59. Brandmaier A, Hou S, Shen W. Cell Cycle Control by PTEN. J Mol Biol. 2017;429:2265-2277 pubmed publisher
    ..Cells lacking PTEN exhibit cell cycle deregulation and cell fate reprogramming. Here, we review the role of PTEN in regulating the key processes in and out of cell cycle to optimize genomic integrity. ..
  60. Laudato S, Patil N, Abba M, Leupold J, Benner A, Gaiser T, et al. P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1. Int J Cancer. 2017;141:1879-1890 pubmed publisher
    ..Finally, we found miR-30e-5p to be lost in resected CRC tumors as compared to normal colon tissues. Taken together, miR-30e-5p is a novel effector of P53-induced suppression of migration, invasion and metastasis. ..
  61. Li M, Mi C, Wang K, Wang Z, Zuo H, Piao L, et al. Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1? signaling. Chem Biol Interact. 2017;274:58-67 pubmed publisher
    ..Moreover, it significantly inhibited tumor growth in a xenograft modal. These findings suggest that shikonin could be considered for use as a potential drug in human colon cancer therapy. ..
  62. Metzler G, Dai X, Thouvenel C, Khim S, Habib T, Buckner J, et al. The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire. J Immunol. 2017;199:2249-2260 pubmed publisher
  63. Liu B, Li J, Zheng M, Ge J, Li J, Yu P. MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2. Life Sci. 2017;188:87-95 pubmed publisher
    ..According to the results, miRNA-542-3p and its targeted FTSJ2 may be indispensable as a predictive biomarker of the response to the treatment in patients with NSCLC. ..
  64. Zambetti G. Expanding the reach of the p53 tumor suppressor network. Cell Death Differ. 2014;21:505-6 pubmed publisher
  65. Guo R, Gu J, Zhang Z, Wang Y, Gu C. MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39. Biomed Res Int. 2017;2017:2381482 pubmed publisher
    ..Our findings improve our understanding of the function of miR-451 in the identification and therapy of pancreatic cancer. ..
  66. Jansen V, Bhola N, Bauer J, Formisano L, Lee K, Hutchinson K, et al. Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer. Cancer Res. 2017;77:2488-2499 pubmed publisher
    ..Taken together, our results highlight a role for the PI3K-PDK1 signaling pathway in mediating acquired resistance to CDK4/6 inhibitors. Cancer Res; 77(9); 2488-99. ©2017 AACR. ..
  67. Sun J, Liu N, Zhuang H, Zhao L, Yuan Z, Wang P. Celecoxib-erlotinib combination treatment enhances radiosensitivity in A549 human lung cancer cell. Cancer Biomark. 2017;19:45-50 pubmed publisher
    ..The underlying mechanisms including the enhancement of apoptosis and radiation-induced G0/G1 arrest, possibly via inhibiting the PI3K/AKT signaling pathway. ..
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